keyword
MENU ▼
Read by QxMD icon Read
search

ATLL

keyword
https://www.readbyqxmd.com/read/29744126/htlv-1-atll-refractory-hypercalcaemia-and-hiv-1-co-infection
#1
Abdullah E Laher, Feroza Motara, Muhammed Moolla, Osman Ebrahim
Adult T-cell lymphoma/leukemia (ATLL) is a rare tumour of T-lymphocytes that is associated with human T-lymphotrophic virus type 1 (HTLV-1) infection as well as severe/refractory hypercalcaemia. Human immunodefficiency virus type 1 (HIV-1) infected individuals are at increased risk of acquiring co-infection with HTLV-1. We present the case of a 37 -year -old HIV-1 positive and antiretroviral therapy naive woman who was admitted to the ICU with delirium, a generalised maculopapular rash, severe hypercalcaemia of 4...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29722927/nf-%C3%AE%C2%BAb-signaling-mechanisms-in-htlv-1-induced-adult-t-cell-leukemia-lymphoma
#2
REVIEW
Edward William Harhaj, Chou-Zen Giam
The human T-cell leukemia virus type 1 (HTLV-1) is a complex deltaretrovirus linked to adult T-cell leukemia/lymphoma (ATLL), a fatal CD4+ malignancy in 3-5% of infected individuals. The HTLV-1 Tax regulatory protein plays indispensable roles in regulating viral gene expression and activating cellular signaling pathways that drive the proliferation and clonal expansion of T cells bearing HTLV-1 proviral integrations. Tax is a potent activator of NF-κB, a key signaling pathway that is essential for the survival and proliferation of HTLV-1 infected T cells...
May 3, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29685460/adult-t-cell-leukemia-lymphoma-review-of-the-literature
#3
M J M Rodríguez-Zúñiga, F Cortez-Franco, E Qujiano-Gomero
Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive neoplasm of T lymphocytes associated with Human T-lymphotropic virus type1 (HTLV-1) infection. HTLV-1 is a public health problem because it is endemic in native groups in Latin America, and its infection leads to several chronic diseases as ATLL. We aimed to review current literature of ATLL in order to consider it as a differential diagnosis in front of patients with compatible symptoms. Prognosis is still poor in aggressive and indolent variants, with survival rates from months to few years...
April 20, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29684346/microrna-3662-expression-correlates-with-antiviral-drug-resistance-in-adult-t-cell-leukemia-lymphoma-cells
#4
Kiyoshi Yasui, Mai Izumida, Takeya Nakagawa, Yoshinao Kubo, Hideki Hayashi, Takashi Ito, Hiroaki Ikeda, Toshifumi Matsuyama
Interferon regulatory factor (IRF) 4 and the proto-oncogene c-Rel cooperate in growth and antiviral drug resistance of adult T-cell leukemia/lymphoma (ATLL). To elucidate the target of IRF4 and c-Rel in ATLL, we determined the simultaneous binding sites of IRF4 and c-Rel using ChIP-seq technology. Nine genes were identified within 2 kb of binding sites, including MIR3662. Expression of miR-3662 was regulated by IRF4, and to a lesser extent by c-Rel. Cell proliferation was inhibited by knockdown of miR-3662 and expression of miR-3662 was correlated with antiviral drug resistance in ATLL cell lines...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29661476/cutaneous-presentation-of-adult-t-cell-leukemia-lymphoma-atll-single-center-study-on-37-patients-in-metropolitan-france-between-1996-and-2016
#5
C Hurabielle, M Battistella, C Ram-Wolff, C Fite, V Meignin, J Rivet, M-D Vignon-Pennamen, T de Risi-Pugliese, E Raffoux, B Arnulf, E Oksenhendler, F Sicre de Fontbrune, R Peffault de Latour, G Socié, J-D Bouaziz, C Lebbé, A Bensussan, M Bagot
INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection. AIM: To describe skin lesions in ATLL. METHODS: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France). RESULTS: Thirty-seven ATLL patients were included. Fifteen patients (41%) had a cutaneous localization of the disease, which was present from the beginning of the disease for two thirds of them...
April 13, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29593659/how-to-control-htlv-1-associated-diseases-preventing-de-novo-cellular-infection-using-antiviral-therapy
#6
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a severe HTLV-1-associated disease: Adult-T-cell leukemia/lymphoma (ATLL), or a neurological disorder named Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). In vivo , HTLV-1 is mostly detected in CD4+ T-cells, and to a lesser extent in CD8+ T cells and dendritic cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29566098/pdz-domain-binding-motif-of-tax-sustains-t-cell-proliferation-in-htlv-1-infected-humanized-mice
#7
Eléonore Pérès, Juliana Blin, Emiliano P Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-replication and T-cell proliferation, a prerequisite to the development of ATLL. In this study, we investigated the in vivo contribution of the Tax PDZ domain-binding motif (PBM) to the lymphoproliferative process. To that aim, we examined T-cell proliferation in humanized mice (hu-mice) carrying a human hemato-lymphoid system infected with either a wild type (WT) or a Tax PBM-deleted (ΔPBM) provirus...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29558516/low-genetic-diversity-of-the-human-t-cell-lymphotropic-virus-htlv-1-in-an-endemic-area-of-the-brazilian-amazon-basin
#8
Akim Felipe Santos Nobre, Danilo de Souza Almeida, Louise Canto Ferreira, Deimy Lima Ferreira, Edivaldo Costa Sousa Júnior, Maria de Nazaré do Socorro de Almeida Viana, Ingrid Christiane Silva, Bruna Teles Pinheiro, Stephen Francis Ferrari, Alexandre da Costa Linhares, Edna Aoba Ishikawa, Rita Catarina Medeiros Sousa, Maísa Silva de Sousa
The Human T-cell Lymphotropic Virus (HTLV-1) is a Deltaretrovírus that was first isolated in the 1970s, and associated with Adult T-cell Leucemia-Lymphoma (ATLL), and subsequently to Tropical Spastic Paraparesis-Myelopathy (TSP/HAM). The genetic diversity of the virus varies among geographic regions, although its mutation rate is very low (approximately 1% per thousand years) in comparison with other viruses. The present study determined the genetic diversity of HTLV-1 in the metropolitan region of Belém, in northern Brazil...
2018: PloS One
https://www.readbyqxmd.com/read/29545256/epidemiology-clinical-features-and-outcome-of-htlv-1-related-atll-in-an-area-of-prevalence-in-the-united-states
#9
Luis Malpica, Agustin Pimentel, Isildinha M Reis, Eduardo Gotuzzo, Lazaros Lekakis, Krishna Komanduri, Thomas Harrington, Glen N Barber, Juan C Ramos
Adult T-cell leukemia/lymphoma (ATLL) is a fatal disease caused by human T-cell leukemia virus type 1 (HTLV-1). We retrospectively analyzed 195 patients with ATLL (lymphomatous n = 96, acute n = 80, unfavorable chronic n = 7, chronic n = 5, smoldering n = 3, and unclassified n = 4) diagnosed between 1987 and 2016 (median age 52 years, 77% Afro-Caribbean). Hypercalcemia was associated with acute ATLL (65%, vs 23% lymphomatous) ( P = .012). The median survival for patients treated with modern therapies between 2000 and 2016 was 4...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29504866/diagnostic-challenges-of-adult-t-cell-leukemia-lymphoma-in-north-america-a-clinical-histological-and-immunophenotypic-correlation-with-a-workflow-proposal
#10
Michael J Licata, Murali Janakiram, Stephanie Tan, Yanan Fang, Urvi A Shah, Amit K Verma, Yanhua Wang
Adult T-cell leukemia-lymphoma (ATLL) is caused by human T-cell lymphotropic virus type 1 (HTLV-1) and little is known about ATLL endemic to the Caribbean basin and Latin America, designated as western ATLL (W-ATLL). Due to extensive systemic involvement and nonspecific clinical presentation, the initial diagnosis in this cohort can be very challenging. We have diagnosed 60 patients with W-ATLL over a 14-year period. ATLL involves the peripheral blood, bone marrow, and cerebrospinal fluid (CSF) in 98, 87, and 52% cases, respectively; while lymphadenopathy, pulmonary infiltrates, splenomegaly, and hepatomegaly was present in 90, 82, 48, and 45% patients, respectively...
May 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29459344/low-level-of-serum-hdl-cholesterol-with-increased-sil-2r-predicts-a-poor-clinical-outcome-for-patients-with-malignant-lymphoma-and-adult-t-cell-leukemia-lymphoma
#11
Ichiro Komiya, Takeaki Tomoyose, Gen Ouchi, Tomohiro Yara, Seishou Higa
Low concentrations of high-density lipoprotein cholesterol (HDL-C) have been reported in patients with hematological malignancies. However, the proof of decreased HDL-C in hematological malignancies and its association with clinical outcomes remain unclear. We analyzed 140 Japanese patients with malignant lymphoma (ML) and adult T-cell leukemia-lymphoma (ATLL). HDL-C, LDL-C and soluble interleukin-2 receptor (sIL-2R) were measured. Treatment decisions were determined with established protocols. HDL-C was 0...
May 2018: Cytokine
https://www.readbyqxmd.com/read/29434288/stem-cell-transplantation-for-t-cell-lymphomas-in-taiwan
#12
Ya-Ting Hsu, Hui-Jen Tsai, Jeffrey S Chang, Sin-Syue Li, Jih-Luh Tang, Su-Peng Yeh, Wen-Li Hwang, Jin-Hwang Liu, Tran-Der Tan, Po-Nan Wang, Hui-Hua Hsiao, Tsai-Yun Chen
T-cell lymphomas are generally aggressive malignancies with poor prognosis. There are no standard treatment guidelines for T-cell lymphomas, and the timing of stem cell transplantation (SCT) is not well known. In this study, we investigated the outcomes of Taiwanese patients with T-cell lymphomas after SCT. We retrospectively analyzed 131 patients with T-cell lymphomas receiving SCT (autologous: 90, allogeneic: 41) from 2009 to 2014. More autologous SCT recipients were ALCL or in complete remission, and more allogeneic recipients had advanced disease...
February 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29414279/mogamulizumab-anti-ccr4-in-htlv-1-associated-myelopathy
#13
Tomoo Sato, Ariella L G Coler-Reilly, Naoko Yagishita, Natsumi Araya, Eisuke Inoue, Rie Furuta, Toshiki Watanabe, Kaoru Uchimaru, Masao Matsuoka, Naoki Matsumoto, Yasuhiro Hasegawa, Yoshihisa Yamano
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1-associated myelopathy-tropical spastic paraparesis (HAM-TSP) as well as adult T-cell leukemia-lymphoma (ATLL). In patients with HAM-TSP, HTLV-1 infects mainly CCR4+ T cells and induces functional changes, ultimately causing chronic spinal cord inflammation. We evaluated mogamulizumab, a humanized anti-CCR4 monoclonal antibody that targets infected cells, in patients with HAM-TSP...
February 8, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29394679/-bowel-perforation-in-a-patient-with-adult-t-cell-leukemia-lymphoma
#14
Shuhei Ota, Tsuyoshi Sunagawa, Morikazu Shimabukuro, Youjirou Mitsumoto, Akihide Tanimoto
Adult T-cell leukemia/lymphoma(ATLL)can infiltrate throughout various organs and frequently involves the gastrointestinal tract. However, bowel perforation in ATLL patients is rare. Herein, we present a case of ATLL with bowel perforation. A 75-year-old man presented with bowel distension. Computed tomography showed a large mass of the cecum. Edema and stenosis of the ascending colon was seen on colonoscopy, and tumor on the anal side of the stenosis was also found. After admission, the patient complained of abdominal pain with a peritoneal irritation sign...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29341283/mogamulizumab-induced-photosensitivity-in-patients-with-mycosis-fungoides-and-other-t-cell-neoplasms
#15
Y Masuda, K Tatsuno, S Kitano, H Miyazawa, J Ishibe, M Aoshima, T Shimauchi, T Fujiyama, T Ito, Y Tokura
BACKGROUND: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma. OBJECTIVE: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog. METHODS: We treated seven cutaneous lymphoma patients with Mog...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29297942/expression-pattern-of-immunosurveillance-related-antigen-in-adult-t-cell-leukaemia-lymphoma
#16
Naoko Asano, Hiroaki Miyoshi, Takeharu Kato, Joji Shimono, Noriaki Yoshida, Daisuke Kurita, Yuya Sasaki, Keisuke Kawamoto, Koichi Ohshima, Masao Seto
AIMS: Adult T cell leukaemia/lymphoma (ATLL) is an aggressive malignancy with a poor prognosis. Human leucocyte antigen (HLA) and β2 microglobulin (β2M) serve as key molecules in tumour immunity, and their expression is reduced frequently in tumour cells. Programmed cell death (PD)-1/PD-ligand1 (PD-L1) interactions play a role in escape of tumour cells from T cell immunity. Therefore, this study aimed to determine the clinicopathological relevance of HLA and β2M expressions in ATLL cells and PD-L1 expression in lymphoma or stromal cells and predict the overall survival of patients with ATLL...
January 3, 2018: Histopathology
https://www.readbyqxmd.com/read/29279551/unilateral-conjunctival-infiltration-of-adult-t-cell-leukemia-lymphoma-case-report-and-literature-review
#17
Joji Shimono, Shigeki Kaino, Kohei Okada, Kazuo Oshimi, Yusuke Ishida, Tatsuro Takahashi, Takuto Miyagishima, Takanori Teshima
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell lymphoma caused by human T-cell leukemia virus type 1 infection. Although conjunctival lymphoma is commonly reported with B-cell lymphoma, it rarely occurs in cases of ATLL. A 73-year-old Japanese female patient was admitted to our institution with evidence of abnormal lymphocytes, lymphadenopathy, and lung nodular lesions. Acute type ATLL was diagnosed, and therapy following the mLSG15 protocol was initiated. At the end of the second course, new bone lesions were detected...
2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29227540/human-t-lymphotropic-virus-1-htlv-1-pathogenesis-a-systems-virology-study
#18
Sayed-Hamidreza Mozhgani, Mohadeseh Zarei-Ghobadi, Majid Teymoori-Rad, Talat Mokhtari-Azad, Mehdi Mirzaie, Mohsen Sheikhi, Seyed-Mohammad Jazayeri, Ramin Shahbahrami, Hedayatollah Ghourchian, Mohieddin Jafari, Seyed-Abdolrahim Rezaee, Mehdi Norouzi
The main mechanisms of interaction between Human T-lymphotropic virus type 1 (HTLV-1) and its hosts in the manifestation of the related disease including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T-cell leukemia/lymphoma (ATLL) are yet to be determined. It is pivotal to find out the changes in the genes expression toward an asymptomatic or symptomatic states. To this end, the systems virology analysis was performed. Firstly, the differentially expressed genes (DEGs) were taken pairwise among the four sample sets of Normal, Asymptomatic Carriers (ACs), ATLL, and HAM/TSP...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29221181/analysis-of-ctcl-cell-lines-reveals-important-differences-between-mycosis-fungoides-s%C3%A3-zary-syndrome-vs-htlv-1-leukemic-cell-lines
#19
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K Watters, John-Douglas Matthew Hughes, Feras M Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville, Ivan V Litvinov
HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL). For many years the role of HTLV-1 in the pathogenesis of MF/SS has been hotly debated. In this study we analyzed CTCL vs. HTLV-1+ leukemic cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29090234/altered-expression-of-cell-cycle-regulators-in-adult-t-cell-leukemia-lymphoma-patients
#20
Reza Torshizi, Ehsan Ghayour Karimani, Kobra Etminani, Mohammad Mehdi Akbarin, Khadijeh Jamialahmadi, Abbas Shirdel, Hossein Rahimi, Abolghasem Allahyari, Amin Golabpour, Houshang Rafatpanah
BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1). HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and compare the HTLV-1 proviral load and the gene expression levels of cyclin-dependent kinase-2 (CDK2), CDK4, p53, and retinoblastoma (Rb) in ATLL and carrier groups...
October 2017: Reports of Biochemistry & Molecular Biology
keyword
keyword
11855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"