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https://www.readbyqxmd.com/read/27917713/antiplatelets-and-antithrombotics-in-patients-with-liver-insufficiency-from-pathophysiology-to-clinical-practice
#1
Melanie Deutsch, John Koskinas
The liver represents the site of synthesis of most procoagulant and anticoagulant factors, fibrinolytic proteins and thrombopoetin while being also involved in the clearance of hemostatic and fibrinolyic proteins. Therefore in patients with liver insufficiency a great variety of disturbances can be documented resulting however in a new "rebalanced" hemostatic system with a labile equilibrium between thromboses or bleeding. Interestingly patients with liver insufficiency may present with arterial or venous thrombotic episodes requiring antiplatelet and/or antithrombotic therapy despite low platelet count or prolonged INR...
December 5, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27913544/treatment-of-rare-factor-deficiencies-in-2016
#2
Flora Peyvandi, Marzia Menegatti
Rare bleeding disorders (RBDs) are a heterogeneous group of coagulation disorders characterized by fibrinogen, prothrombin, factors V, VII, X, XI, or XIII (FV, FVII, FX, FXI, or FXIII, respectively), and the combined factor V + VIII and vitamin K-dependent proteins deficiencies, representing roughly 5% of all bleeding disorders. They are usually transmitted as autosomal, recessive disorders, and the prevalence of the severe forms could range from 1 case in 500 000 for FVII up to 1 in 2-3 million for FXIII in the general population...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27881059/natural-products-with-antiplatelet-action
#3
Gabriela Elisa Hirsch, Paulo Ricardo Nazário Viecili, Amanda Spring de Almeida, Sabrina Nascimento, Fernando Garcez Porto, Juliana Otero, Aline Schmidt, Brenda da Silva, Mariana Migliorini Parisi, Jonatas Zeni Klafke
BACKGROUND: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27843779/the-role-of-non-steroidal-anti-inflammatory-drugs-nsaids-in-the-treatment-of-patients-with-hepatic-disease-a-review-article
#4
REVIEW
Maryam Soleimanpour, Farnad Imani, Saeid Safari, Sarvin Sanaie, Hassan Soleimanpour, Hoorolnesa Ameli, Seyed Moayed Alavian
CONTEXT: Patients with hepatic dysfunction suffer from many problems and associated complications in organs other than the liver. Therefore, it is very important to investigate the effects of different drugs in the treatment of these patients. Due to the high consumption of non-steroidal anti-inflammatory drugs (NSAIDs), studying the effects of these drugs in patients with hepatic dysfunction is particularly important. EVIDENCE ACQUISITION: Research studies published from 1958 to 2014 were investigated in the present study...
August 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27785141/postponed-surgery-of-an-acute-aortic-dissection-type-a-in-a-jehovah-s-witness-with-significant-hemostatic-disorders
#5
Andrzej Biskupski, Szymon Waligórski, Krzysztof Mokrzycki, Mirosław Brykczyński
In this case report, we present the treatment of an acute type A aortic dissection in a Jehovah's Witness patient. In accordance with the will of the patient, blood products were not used. Additionally, the patient had significant hemostatic disorders due to the use of antiplatelet drugs.
September 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/27780267/postpartum-hemorrhage-in-women-with-von-willebrand-disease-a-retrospective-observational-study
#6
Igor Govorov, Signe Löfgren, Roza Chaireti, Margareta Holmström, Katarina Bremme, Miriam Mints
INTRODUCTION: von Willebrand disease (VWD) is a hereditary bleeding disorder, caused by a deficiency in the levels and/or function of von Willebrand factor (VWF). Women with VWD appear to be at increased risk of experiencing postpartum hemorrhage (PPH), though the levels of VWF increase during pregnancy. There is limited knowledge of how PPH is associated with the subtype of VWD, plasma levels of other coagulations factors than VWF and given hemostatic treatment. AIMS: The aims were to investigate the incidence of PPH in women with VWD and to analyse the correlation between PPH and: (1) type of VWD, (2) laboratory monitoring of VWF and FVIII and (3) hemostatic drug treatment...
2016: PloS One
https://www.readbyqxmd.com/read/27768934/the-proteasome-regulates-collagen-induced-platelet-aggregation-via-nuclear-factor-kappa-b-nf%C3%A4-b-activation
#7
Katharina Grundler, Raffaela Rotter, Sloane Tilley, Joachim Pircher, Thomas Czermak, Mustaf Yakac, Erik Gaitzsch, Steffen Massberg, Florian Krötz, Hae-Young Sohn, Ulrich Pohl, Hanna Mannell, Bjoern F Kraemer
INTRODUCTION: Platelets possess critical hemostatic functions in the system of thrombosis and hemostasis, which can be affected by a multitude of external factors. Previous research has shown that platelets have the capacity to synthesize proteins de novo and more recently a multicatalytic protein complex, the proteasome, has been discovered in platelets. Due to its vital function for cellular integrity, the proteasome has become a therapeutic target for anti-proliferative drug therapies in cancer...
October 13, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27714941/bevacizumab-for-non-small-cell-lung-cancer-a-nested-case-control-study-of-risk-factors-for-hemoptysis
#8
Koichi Goto, Masahiro Endo, Masahiko Kusumoto, Nobuyuki Yamamoto, Yuichiro Ohe, Ayaka Shimizu, Masahiro Fukuoka
Potentially life-threatening, serious hemoptysis is an adverse event associated with bevacizumab in non-squamous non-small-cell lung cancer (NSCLC) trials. Suggested risk factors include central tumor location and cavitation; however, the profile of hemoptysis occurrence in clinical practice is still unclear. A nested case-control study was conducted to assess the onset profile and risk factors for hemoptysis in bevacizumab-treated patients in a real-world setting in Japan. After bevacizumab was approved for NSCLC, Physicians registered all NSCLC patients scheduled for bevacizumab therapy, from November 2009 to August 2011...
October 6, 2016: Cancer Science
https://www.readbyqxmd.com/read/27705733/a-standardized-surgical-technique-for-removal-of-the-interstim-tined-lead
#9
Matthew E Sterling, Siobhan M Hartigan, Alan J Wein, Ariana L Smith
INTRODUCTION: Explantation of the Interstim sacral neuromodulation (SNM) device is occasionally necessary. Removing the tined lead can put strain on the lead, resulting in a possible break and retained fragments. The Food and Drug Administration (FDA) released a notification regarding health consequences related to retained lead fragments. We describe a novel and safe surgical technique for removing the Interstim device and permanent lead. MATERIALS AND METHODS: We searched the Manufacturer and User Facility Device Experience (MAUDE) database for complications related to tined lead removal and searched the database of a single surgeon at our institution...
October 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27684194/ferric-chloride-induced-murine-thrombosis-models
#10
Wei Li, Marvin Nieman, Anirban Sen Gupta
Arterial thrombosis (blood clot) is a common complication of many systemic diseases associated with chronic inflammation, including atherosclerosis, diabetes, obesity, cancer and chronic autoimmune rheumatologic disorders. Thrombi are the cause of most heart attacks, strokes and extremity loss, making thrombosis an extremely important public health problem. Since these thrombi stem from inappropriate platelet activation and subsequent coagulation, targeting these systems therapeutically has important clinical significance for developing safer treatments...
September 5, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27647994/preventative-effects-of-sodium-alginate-on-indomethacin-induced-small-intestinal-injury-in-mice
#11
Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Shigeto Mizuno, Yoshiyuki Rikitake
Recent advances in diagnostic technologies have revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) can cause serious mucosal injury in the upper and lower gastrointestinal tract (including the small intestine). A drug to treat NSAID-induced small-intestinal injury (SII) is lacking. Sodium alginate is a soluble dietary fiber extracted from brown seaweed and its solution has been used as a hemostatic agent to treat gastrointestinal bleeding due to gastric ulcers. Whether sodium alginate has therapeutic effects on NSAID-induced SII and its mechanism of action are not known...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27641750/expression-purification-and-analysis-of-three-recombinant-ecd-disintegrins-r-colombistatins-from-p-iii-class-snake-venom-metalloproteinases-affecting-platelet-aggregation-and-sk-mel-28-cell-adhesion
#12
Montamas Suntravat, Thomas J Helmke, Chairat Atphaisit, Esteban Cuevas, Sara E Lucena, Nestor L Uzcátegui, Elda E Sánchez, Alexis Rodriguez-Acosta
Crotalid venoms are rich sources of components that affect the hemostatic system. Snake venom metalloproteinases are zinc-dependent enzymes responsible for hemorrhage that also interfere with hemostasis. The disintegrin domain is a part of snake venom metalloproteinases, which involves the binding of integrin receptors. Integrins play an essential role in cancer survival and invasion, and they have been major targets for drug development and design. Both native and recombinant disintegrins have been widely investigated for their anti-cancer activities in biological systems as well as in vitro and in vivo systems...
November 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27590165/advances-in-the-treatment-of-bleeding-disorders
#13
F Peyvandi, I Garagiola, E Biguzzi
Historically, the bleeding episodes in subjects with coagulation disorders were treated with substitution therapy, initially with whole blood and fresh frozen plasma, and more recently with specific factor concentrate. Currently, patients with hemophilia have the possibility of choosing different effective and safe treatments, including novel extended half-life and alternative hemostatic drugs. The availability of novel extended half-life products could probably overcome current prophylaxis limitations, particularly in hemophilia B patients, by reducing the frequency of injections, achieving a higher trough level, and improving the quality of life of the patients...
September 2, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27573206/andexanet-alfa-for-acute-major-bleeding-associated-with-factor-xa-inhibitors
#14
Stuart J Connolly, Truman J Milling, John W Eikelboom, C Michael Gibson, John T Curnutte, Alex Gold, Michele D Bronson, Genmin Lu, Pamela B Conley, Peter Verhamme, Jeannot Schmidt, Saskia Middeldorp, Alexander T Cohen, Jan Beyer-Westendorf, Pierre Albaladejo, Jose Lopez-Sendon, Shelly Goodman, Janet Leeds, Brian L Wiens, Deborah M Siegal, Elena Zotova, Brandi Meeks, Juliet Nakamya, W Ting Lim, Mark Crowther
Background Andexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers. Methods In this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major bleeding within 18 hours after the administration of a factor Xa inhibitor. The patients all received a bolus of andexanet followed by a 2-hour infusion of the drug. Patients were evaluated for changes in measures of anti-factor Xa activity and were assessed for clinical hemostatic efficacy during a 12-hour period...
September 22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27513238/the-antioxidant-and-antimutagenic-activities-of-ankaferd-blood-stopper-a-natural-hemostatic-agent-used-in-dentistry
#15
Aysel Uğur, Nurdan Saraç, Dilek Aynur Çankal, Murat Özle
BACKGROUND/AIM: This study investigated the antioxidant and antimutagenic properties of Ankaferd blood stopper (ABS), a plant-based topical hemostatic agent used in Turkey to treat external hemorrhages and bleeding during dental surgery. While previous studies have examined the antimicrobial, antiinflammatory, and anticarcinogenic properties of ABS, to our knowledge, this is the first study to report on the antioxidant and antimutagenic activities of this drug. MATERIALS AND METHODS: Antioxidant activity was evaluated using DPPH radical-scavenging and β-carotene-linoleic acid tests...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27492699/pt-aptt-tt-and-the-hemostatic-safety-threshold-of-dabigatran-and-rivaroxaban
#16
Firas Ibrahim, Leyla Calmette, Ayham Layka, Marie-Hélène Horellou, Élisabeth Mazoyer, Isabelle Gouin-Thibault, Claire Flaujac
The proposals of the Working group on perioperative hemostasis (Groupe d'intérêt en hémostase péri-opératoire (GIHP)) concerning the perioperative management of patients receiving the direct oral anticoagulants (DOACs) are based on the measure of their anticoagulant activities (anti-Xa for rivaroxaban and anti-IIa for dabigatran) with a safety threshold ≤ 30 ng/mL. If the dosage of the drug is not available, proposals are based on the combination of a PT ≥80% and an aPTT ≤1.20. The aim of our study was to evaluate the performance of PT, aPTT and thrombin time to predict values above or below the safety threshold...
August 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27491379/preparation-and-evaluation-of-novel-hydrogel-based-on-polysaccharide-isolated-from-bletilla-striata
#17
Xiuming Cui, Xingying Zhang, Ye Yang, Chengxiao Wang, Chaoyu Zhang, Gang Peng
Natural polysaccharides are highly valued and extensively applied in drug delivery system for their desirable physical properties and unique bioactivities. In this work, natural polysaccharides from Bletilla striata (BSP) were successfully extracted and incorporated with Carbopol 940 to prepare hydrogels. Rheological behavior, skin permeation properties and bioactivities of the BSP hydrogels were evaluated. The rheological test showed the better viscoelasticity and physical strength of BSP gels from Carbopol gel...
August 4, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27457694/evaluation-of-cynodon-dactylon-for-wound-healing-activity
#18
Tuhin Kanti Biswas, Srikanta Pandit, Shrabana Chakrabart, Saheli Banerjee, Nandini Poyra, Tapan Seal
BACKGROUND AND AIMS: Research in the field of wound healing is very recent. The concept of wound healing is changing from day to day. Ayurveda is the richest source of plant drugs for management of wounds and Cynodon dactylon L. is one such. The plant is used as hemostatic and wound healing agent from ethnopharmacological point of view. Aim of the present study is scientific validation of the plant for wound healing activity in detail. MATERIALS AND METHODS: Aqueous extract of the plant was prepared and phytochemical constituents were detected by HPLC analysis...
July 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27441219/evaluation-of-percutaneous-microwave-coagulation-therapy-for-hepatic-artery-injury
#19
Yuanyuan Sun, Guoming Zhang, Jie Yu, Lei Dong, Wei Liu, Ping Liang
OBJECTIVES: To evaluate the in vivo efficacy of 915 MHz percutaneous coagulation in the treatment of hepatic artery injury. METHODS: After inducing hepatic artery injury, 8 dogs in each group underwent 915 MHz microwave percutaneous coagulation therapy and 8 dogs were injected with batroxobin and α-cyanoacrylate. RESULTS: The hemostatic effects of 915 MHz microwave were better than drug injection, and the amount of bleeding was significantly lower (p < 0...
October 2015: Heliyon
https://www.readbyqxmd.com/read/27333841/a-swine-model-of-acute-thrombocytopenia-with-prolonged-bleeding-time-produced-by-busulfan
#20
Tomoyuki Abe, Shota Kono, Takahiro Ohnuki, Shuji Hishikawa, Satoshi Kunita, Yutaka Hanazono
Animal models of thrombocytopenia are indispensable for evaluating the in vivo efficacy of hemostatic agents, cryopreserved platelets, and artificial platelets, but no large animal models are available. In this study, we generated a swine model of acute thrombocytopenia with prolonged bleeding times by administering the chemotherapeutic drug busulfan. First, we tested multiple doses of busulfan (4, 6, and 8 mg/kg) in pigs, and found that 6 mg/kg of busulfan is an optimal dose for producing a safe and moderate thrombocytopenia, with a platelet count of less than 30,000/µl...
November 1, 2016: Experimental Animals
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