Roby Joehanes, Saixia Ying, Tianxiao Huan, Andrew D Johnson, Nalini Raghavachari, Richard Wang, Poching Liu, Kimberly A Woodhouse, Shurjo K Sen, Kahraman Tanriverdi, Paul Courchesne, Jane E Freedman, Christopher J O'Donnell, Daniel Levy, Peter J Munson
OBJECTIVE: To identify transcriptomic biomarkers of coronary heart disease (CHD) in 188 cases with CHD and 188 age- and sex-matched controls who were participants in the Framingham Heart Study. APPROACH AND RESULTS: A total of 35 genes were differentially expressed in cases with CHD versus controls at false discovery rate<0.5, including GZMB, TMEM56, and GUK1. Cluster analysis revealed 3 gene clusters associated with CHD, 2 linked to increased erythrocyte production and a third to reduced natural killer and T cell activity in cases with CHD...
June 2013: Arteriosclerosis, Thrombosis, and Vascular Biology