Alicja E Grzegorzewska, Grzegorz Ostromecki, Paulina Zielińska, Adrianna Mostowska, Zofia Niemir, Magdalena Polcyn-Adamczak, Magdalena Pawlik, Anna Sowińska, Paweł P Jagodziński
BACKGROUND Vitamin D (VD), VD binding protein, VD receptor (VDR), and retinoids are involved in pathogenesis of chronic glomerulonephritis (ChGN). We aimed to compare distribution of VD pathway gene polymorphisms in ChGN patients showing glomerular filtration rate (GFR) category 1-3, GFR category 5D, and healthy controls in order to elucidate the role of VD-related polymorphisms in the course of ChGN. MATERIAL AND METHODS GFR category 1-3 ChGN patients (n=195), GFR category 5D ChGN patients (n=178), and controls (n=751) underwent testing for polymorphisms of genes encoding VD binding protein (GC, rs2298849, rs7041, rs1155563), VDR (VDR, rs2228570, rs1544410), and retinoid X receptor alpha (RXRA, rs10776909, rs10881578, rs749759)...
November 27, 2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research