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https://www.readbyqxmd.com/read/27591407/human-papillomavirus-test-with-cytology-triage-in-organized-screening-for-cervical-cancer
#1
Olga Veijalainen, Saara Kares, Paula Kujala, Mika Tirkkonen, Risto Vuento, Ivana Kholová, Tiina Luukkaala, Veronika Osuala, Johanna Mäenpää
INTRODUCTION: In randomized studies, testing for high-risk (HR) human papillomavirus (hrHPV) has been more sensitive than conventional cytology in detecting cervical intraepithelial neoplasia (CIN). The aim of this study was to evaluate the performance of HPV testing in the setting of an organized routine screening program. MATERIAL AND METHODS: Since 2012, 35- to 60-year-old women living in the city of Tampere have been screened with the Abbott RealTime hrHPV test...
November 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/26810046/predictors-of-hypertension-in-survivors-of-the-great-east-japan-earthquake-2011-a-cross-sectional-study
#2
Reiichiro Tanaka, Motohisa Okawa, Yoshihito Ujike
INTRODUCTION: Many survivors of a major disaster die shortly after the event. Hypertension (HT) is one of the most important risk factors for these disaster-related diseases. An urgent need exists to establish methods to detect disaster survivors with HT and start medication immediately, as those with no injuries or symptoms may not be examined and medical teams cannot measure all survivors' blood pressure (BP) because they often do not have sufficient time. OBJECTIVE: The goals of this report were: (1) to evaluate the importance of taking antihypertensive drugs continuously for patients with HT during the sub-acute phase after a major earthquake, when patients cannot attend a clinic because of destruction of the local infrastructure; and (2) to establish simple and reliable predictors to detect evacuees with HT, who require clinical examination and treatment at evacuation shelters or in their homes after a major earthquake...
February 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/25443131/a-telephone-reminder-intervention-to-improve-breast-screening-information-and-access
#3
J Offman, J Myles, S Ariyanayagam, Z Colorado, M Sharp, M Cruice, B V North, S Shiel, T Baker, R Jefferies, K Binysh, S W Duffy
OBJECTIVES: In the UK, women aged 50-70 are offered breast cancer screening every three years. Screening participation rates in London have been particularly low. Low rates have been associated with low socio-economic status, and some ethnic groups have been observed to be underserved by cancer screening. This paper reports on a telephone reminder intervention in London Newham, an area of high deprivation and ethnic diversity. STUDY DESIGN: Observational study of planned intervention...
November 2014: Public Health
https://www.readbyqxmd.com/read/25282285/lung-cancer-probability-in-patients-with-ct-detected-pulmonary-nodules-a-prespecified-analysis-of-data-from-the-nelson-trial-of-low-dose-ct-screening
#4
RANDOMIZED CONTROLLED TRIAL
Nanda Horeweg, Joost van Rosmalen, Marjolein A Heuvelmans, Carlijn M van der Aalst, Rozemarijn Vliegenthart, Ernst Th Scholten, Kevin ten Haaf, Kristiaan Nackaerts, Jan-Willem J Lammers, Carla Weenink, Harry J Groen, Peter van Ooijen, Pim A de Jong, Geertruida H de Bock, Willem Mali, Harry J de Koning, Matthijs Oudkerk
BACKGROUND: The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for nodule size and growth rate to determine which nodules require additional diagnostic procedures, but these should be based on individuals' probabilities of developing lung cancer. In this prespecified analysis, using data from the NELSON CT screening trial, we aimed to quantify how nodule diameter, volume, and volume doubling time affect the probability of developing lung cancer within 2 years of a CT scan, and to propose and evaluate thresholds for management protocols...
November 2014: Lancet Oncology
https://www.readbyqxmd.com/read/25282284/detection-of-lung-cancer-through-low-dose-ct-screening-nelson-a-prespecified-analysis-of-screening-test-performance-and-interval-cancers
#5
RANDOMIZED CONTROLLED TRIAL
Nanda Horeweg, Ernst Th Scholten, Pim A de Jong, Carlijn M van der Aalst, Carla Weenink, Jan-Willem J Lammers, Kristiaan Nackaerts, Rozemarijn Vliegenthart, Kevin ten Haaf, Uraujh A Yousaf-Khan, Marjolein A Heuvelmans, Erik Thunnissen, Matthijs Oudkerk, Willem Mali, Harry J de Koning
BACKGROUND: Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and others can develop in the interval between screens. The NELSON trial is a randomised trial to assess the effect of screening with increasing screening intervals on lung cancer mortality. In this prespecified analysis, we aimed to assess screening test performance, and the epidemiological, radiological, and clinical characteristics of interval cancers in NELSON trial participants assigned to the screening group...
November 2014: Lancet Oncology
https://www.readbyqxmd.com/read/25210073/clinical-evaluation-of-a-gp5-6-based-luminex-assay-having-full-high-risk-human-papillomavirus-genotyping-capability-and-an-internal-control
#6
COMPARATIVE STUDY
D T Geraets, K Cuschieri, M N C de Koning, L J van Doorn, P J F Snijders, C J L M Meijer, W G V Quint, M Arbyn
The LMNX genotyping kit HPV GP (LMNX) is based on the clinically validated GP5+/6+ PCR, with a genotyping readout as an alternative for the more established enzyme immunoassay (EIA) detection of 14 targeted high-risk human papillomavirus (HPV) types. LMNX is additionally provided with an internal control probe. Here, we present an analysis of the clinical performance of the LMNX using a sample panel and infrastructure provided by the international VALGENT (Validation of Genotyping Tests) project. This panel consisted of cervical specimens from approximately 1,000 women attending routine screening, "enriched" with 300 women with abnormal cytology...
November 2014: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/24762804/the-clinical-effectiveness-and-cost-effectiveness-of-primary-human-papillomavirus-cervical-screening-in-england-extended-follow-up-of-the-artistic-randomised-trial-cohort-through-three-screening-rounds
#7
RANDOMIZED CONTROLLED TRIAL
Henry C Kitchener, Karen Canfell, Clare Gilham, Alexandra Sargent, Chris Roberts, Mina Desai, Julian Peto
BACKGROUND: The ARTISTIC (A Randomised Trial In Screening To Improve Cytology) trial originally reported after two rounds of primary cervical screening with human papillomavirus (HPV). Extended follow-up of the randomised trial cohort through a third round could provide valuable insight into the duration of protection of a negative HPV test, which could allow extended screening intervals. If HPV primary screening is to be considered in the national programme, then determining its cost-effectiveness is key, and a detailed economic analysis using ARTISTIC data is needed...
April 2014: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/24293498/-tailored-breast-screening-trial-tbst
#8
RANDOMIZED CONTROLLED TRIAL
Eugenio Paci, Paola Mantellini, Paolo Giorgi Rossi, Patrizia Falini, Donella Puliti
BACKGROUND: mammography screening in premenopausal women is still the object of controversy and the cost and harms-benefit balance is lower than the one observed for women aged 50 years or more. The reasons are the lower screening sensitivity and the lower risk of occurrence of breast cancer at younger ages. For these reasons, an annual interval is suggested for this age group, and a lower positive predictive value of the recall rate is observed in screening practice. Harms of screening are false positive rates and overdiagnosis (that is an exceeding number of cases over the women's lifetime ascribable to early diagnosis)...
July 2013: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/23360535/mammographic-density-and-risk-of-breast-cancer-according-to-tumor-characteristics-and-mode-of-detection-a-spanish-population-based-case-control-study
#9
Marina Pollán, Nieves Ascunce, María Ederra, Alberto Murillo, Nieves Erdozáin, Jose Alés-Martínez, Roberto Pastor-Barriuso
INTRODUCTION: It is not clear whether high mammographic density (MD) is equally associated with all subtypes of breast cancer (BC). We investigated the association between MD and subsequent BC, considering invasiveness, means of detection, pathologic subtype, and the time elapsed since mammographic exploration and BC diagnosis. METHODS: BC cases occurring in the population of women who attended screening from 1997 through 2004 in Navarre, a Spanish region with a fully consolidated screening program, were identified via record linkage with the Navarre Cancer Registry (n = 1,172)...
2013: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/23287764/the-ota-open-fracture-classification-a-study-of-reliability-and-agreement
#10
Julie Agel, Andrew R Evans, John Lawrence Marsh, Thomas A Decoster, Douglas W Lundy, James F Kellam, Clifford B Jones, Gregory L Desilva
OBJECTIVES: To determine the reliability of the Orthopaedic Trauma Association (OTA) Open Fracture Classification. DESIGN: Video-based reliability study. SETTING: Orthopedic meetings and grand rounds. PATIENTS/PARTICIPANTS: Orthopedic surgeons. INTERVENTION: None. MAIN OUTCOME MEASUREMENTS: Interobserver reliability assessment classification. RESULTS: The results demonstrate the system to have high reliability and much improvement compared with published Gustilo-Anderson classification reliability studies...
July 2013: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/22177579/human-papillomavirus-testing-for-the-detection-of-high-grade-cervical-intraepithelial-neoplasia-and-cancer-final-results-of-the-pobascam-randomised-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Dorien C Rijkaart, Johannes Berkhof, Lawrence Rozendaal, Folkert J van Kemenade, Nicole W J Bulkmans, Daniëlle A M Heideman, Gemma G Kenter, Jack Cuzick, Peter J F Snijders, Chris J L M Meijer
BACKGROUND: Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed. The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening. METHODS: In this randomised trial, women aged 29-56 years participating in the cervical screening programme in the Netherlands were randomly assigned to receive HPV DNA (GP5+/6+-PCR method) and cytology co-testing or cytology testing alone, from January, 1999, to September, 2002...
January 2012: Lancet Oncology
https://www.readbyqxmd.com/read/21144200/staphylococcus-aureus-carriage-among-gps-in-the-netherlands
#12
Michelle Ia Rijnders, Sita Nys, Christel Driessen, Christian Jpa Hoebe, Rogier M Hopstaken, Guy J Oudhuis, Arno Timmermans, Ellen E Stobberingh
BACKGROUND: The extent to which GPs serve as a reservoir for antibiotic-resistant Staphylococcus aureus is unknown and not well studied. AIM: To determine the prevalence of nasal S. aureus carriage among GPs in the Netherlands, as well as the antimicrobial resistance and the genotypes of isolated S. aureus. DESIGN OF STUDY: Observational, point-prevalence, and cross-sectional study. SETTING: GPs attending the annual conference of the Dutch College of General Practitioners in 2006...
December 2010: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/21047586/psa-levels-and-cancer-detection-rate-by-centre-in-the-european-randomized-study-of-screening-for-prostate-cancer
#13
S J Otto, S M Moss, L Määttänen, M Roobol, M Zappa, V Nelen, M Kwiatkowski, A Villers, J Hugosson, A Berenguer Sanchez, H J de Koning
BACKGROUND: To describe the variation in PSA level by age group and screening round in the ERSPC centres and the variation in cancer detection rates in relation to the underlying prostate cancer incidence. METHODS: Individual data on men invited for the first and second screening rounds according to protocol (excluding early recalls and interval cancers) were obtained from the central database of the ERSPC (cut-off date 31st December 2006). Data were compared between and within centres for the core age group (55-69 at entry)...
November 2010: European Journal of Cancer
https://www.readbyqxmd.com/read/19931832/inconsistencies-in-self-reporting-of-sexual-activity-among-young-people-in-nairobi-kenya
#14
Donatien Beguy, Caroline W Kabiru, Evangeline N Nderu, Moses W Ngware
PURPOSE: Accurate and reliable data on the prevalence of adolescents' sexual behavior are paramount for effective sexual and reproductive health intervention. Adolescents' sexual behavior has been widely studied. However, scholars have raised concerns about the accuracy and reliability of self-reported sexual behavior by adolescents. Previous research shows high levels of adolescent sexual activity in urban informal settlements; yet, the accuracy of self-reported sexual experience in these settings is understudied...
December 2009: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/19463206/allergic-sensitization-to-domestic-mites-in-corpus-christi-texas
#15
James Caplin, Arnaldo Capriles-Hulett, Victor Iraola, Helder Pinto, Mario Sánchez-Borges, Gloria de los Santos, Enrique Fernández-Caldas
Corpus Christi, TX, is a Gulf Coast city with high humidity levels year-round. There is little available data on mite species in mattress dust, allergen levels, and sensitization to different mite species in allergic patients. This study was designed to determine skin sensitization and specific serum IgE to Dermatophagoides spp. and Blomia tropicalis in patients attending an allergy clinic and to explore the mite fauna and allergen content of their mattresses. Skin-prick tests to Dermatophagoides spp. and B...
March 2009: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/15949121/high-participation-rates-are-not-necessary-for-cost-effective-colorectal-cancer-screening
#16
Kirsten Howard, Glenn Salkeld, Les Irwig, Barbara-Ann Adelstein
BACKGROUND: In many countries high participation is an explicit target in screening programmes. The desire for high participation often appears to drive screening policy, although it is increasingly recognized that encouraging high participation may impinge upon the rights of an individual to make an informed choice. One argument offered in support of high participation is that it improves the cost-effectiveness of screening. This is questionable on theoretical grounds, and empirically there are conflicting results...
2005: Journal of Medical Screening
https://www.readbyqxmd.com/read/12430761/prevalence-of-malnutrition-in-rural-karnataka-south-india-a-comparison-of-anthropometric-indicators
#17
Bobby Joseph, Aaron Rebello, Poonam Kullu, Vimal D Raj
Malnutrition is a problem at varying proportions in developing countries, and anthropometry is a simple tool to assess its magnitude in children. This study was aimed at identifying the prevalence of malnutrition among 256 children of rural areas of Karnataka in South India, who attended the aanganwadis. The value of using various field-based formulae and of various anthropometric indicators used for classification of malnutrition was also studied. The children, aged 12-60 months, came from villages located at the outskirts of Bangalore city...
September 2002: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/11002452/the-sensitivity-specificity-and-positive-predictive-value-of-screening-mammography-and-symptomatic-status
#18
A M Kavanagh, G G Giles, H Mitchell, J N Cawson
OBJECTIVE: To examine whether the accuracy of screening mammography varies according to symptomatic status reported at the time of screening. SETTING: Victoria, Australia, where free biennial screening is provided to women aged 40 and older. METHODS: We examined the sensitivity, specificity, and the positive predictive value of screening mammography by symptom status in 106,826 women from Victoria, who attended for first round mammography in 1994 and who did not have a personal history of breast cancer...
2000: Journal of Medical Screening
https://www.readbyqxmd.com/read/10444726/psychosocial-predictors-of-first-attendance-for-organised-mammography-screening
#19
RANDOMIZED CONTROLLED TRIAL
A R Aro, H J de Koning, P Absetz, M Schreck
OBJECTIVE: To study psychosocial predictors of attendance at an organised breast cancer screening programme. SETTING: Finnish screening programme based on personal first round invitations in 1992-94, and with 90% attendance rate. METHODS: Attenders (n = 946) belonged to a 10% random sample (n = 1680 women, age 50, response rate 64%) of the target population (n = 16,886), non-attenders (n = 641, 38%) came from the whole target population. Predictors were measured one month before the screening invitation...
1999: Journal of Medical Screening
https://www.readbyqxmd.com/read/10093130/parietaria-allergy-in-children
#20
J Botey, A Torres, J Belmonte, J L Eseverri, A Marin
Parietaria, a grassy plant belonging to the Urticaceae family which is commonly found in urban environments, tends to grow on fences, walls and soils with a high content in nitrogen. Since 1983 the Xarxa Aerobiologica de Catalunya (Catalonian Aerobiological Network) has been using Hirst and Court sensors to monitor the daily concentrations of its pollen with respect to the weather conditions (wind, rain, temperature) in various sites in Catalonia and the Balearic Islands. This pollen is present practically all year round in our area, mainly during cold, rainy and seaside areas...
1999: Pediatric Pulmonology. Supplement
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