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https://www.readbyqxmd.com/read/29777692/an-optimal-serum-free-defined-condition-for-in-vitro-culture-of-kidney-organoids
#1
Masaki Nishikawa, Hiroshi Kimura, Naomi Yanagawa, Morgan Hamon, Peter Hauser, Lifu Zhao, Oak D Jo, Norimoto Yanagawa
Kidney organoid is an emerging topic of importance for research in kidney development and regeneration. Conventional culture systems for kidney organoids reported thus far use culture media containing serum, which may compromise our understanding and the potential clinical applicability of the organoid system. In our present study, we tested two serum-free culture conditions and compared their suitability for the maintenance and growth of kidney organoids in culture. One of the serum-free culture conditions was the combination of keratinocytes serum free medium (KSFM) with knockout serum replacement (KSR) (KSFM + KSR), and the other was the combination of knockout DMEM/F12 (KD/F12) and KSR (KD/F12 + KSR)...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774822/partial-nephrectomy-in-central-renal-tumors
#2
Sohrab Arora, Craig Rogers
Nephron-sparing surgery, especially through a minimally invasive approach, is increasingly being performed for incidentally detected renal masses with excellent outcomes. Tumors in central location remain a surgical challenge during nephron-sparing surgery. In this chapter, we discuss the minimally invasive management of these tumors, which include complex hilar tumors and endophytic central tumors, with a focus on surgical technique. The key to management of these tumors is to maintain good preoperative hydration, achieving adequate exposure of tumor, and the use of intraoperative ultrasound to plan the resection plane...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774809/robotic-partial-nephrectomy-for-a-peripheral-renal-tumor
#3
Caleb A Cooper, Cheuk Fan Shum, Chandru P Sundaram
Partial nephrectomy (PN) is the preferred surgical treatment for T1 renal tumors whenever technically feasible. When properly performed, it allows preservation of nephron mass without compromising oncologic outcomes. This reduces the postoperative risk of renal insufficiency, which translates into better overall survival for the patients. PN can be technically challenging, because it requires the surgeon to complete the tasks of tumor excision, hemostasis and renorrhaphy, all within an ischemic time of preferably below 30 minutes...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29770967/developmental-programming-of-renal-function-nephron-endowment-and-beyond
#4
Andrew G Woodman, Stephane L Bourque
In the face of adversity, the fetal kidney doesn't fare well. When resources are limiting due to pregnancy complications such as placental insufficiency, maternal hypoxia, or nutrient deficiencies, kidney development is often compromised, showing signs of reduced growth, defective nephrogenesis, and abnormal morphology. This article is protected by copyright. All rights reserved.
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29770263/evaluation-of-quantitative-and-qualitative-renal-outcome-following-nephron-sparing-surgery
#5
Gautam Ram Choudhary, Arup Kumar Mandal, Uttam Mete, Ravimohan Mavuduru, Anish Bhatacharia, Anupam Lal, Suresh Goyal
Purpose: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. Patients and Methods: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29766469/proteinuric-glomerulopathy-in-an-adolescent-with-a-distal-partial-trisomy-chromosome-1
#6
Takaya Sasaki, Masahiro Okabe, Takeshi Tosaki, Yu Honda, Masahiro Ishikawa, Nobuo Tsuboi, Takashi Yokoo
We report a case of distal partial trisomy 1 from q32.1 to 41 that have exhibited proteinuric glomerulopathy. The patient was a 17-year-old adolescent with clinical features of low birth weight, mild mental retardation and mild deafness, from the birth. He exhibited non-nephrotic range proteinuria with the mild obesity since the age of sixteen. Image studies did not reveal morphological abnormalities of the kidneys. Renal biopsy findings showed no definitive evidence of primary glomerular diseases, and were characterized by a very low glomerular density, glomerulomegaly and focal effacement of podocyte foot processes...
May 16, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29764415/perioperative-outcomes-of-zero-ischemia-radiofrequency-ablation-assisted-tumor-enucleation-for-renal-cell-carcinoma-results-of-182-patients
#7
Chengwei Zhang, Xiaozhi Zhao, Suhan Guo, Changwei Ji, Wei Wang, Hongqian Guo
BACKGROUND: To evaluate the perioperative outcomes of zero ischemia radiofrequency ablation-assisted tumor enucleation. METHODS: Patients undergoing zero ischemia radiofrequency ablation-assisted tumor enucleation were retrospectively identified from July 2008 to March 2013. The tumor was enucleated after RFA treatment. R.E.N.A.L., PADUA and centrality index (C-index) score systems were used to assess each tumor case. We analyzed the correlation of perioperative outcomes with these scores...
May 15, 2018: BMC Urology
https://www.readbyqxmd.com/read/29760664/reduced-renal-mass-salt-sensitive-hypertension-is-resistant-to-renal-denervation
#8
Ionut Tudorancea, Thomas E Lohmeier, Barbara T Alexander, Dragos Pieptu, Dragomir N Serban, Radu Iliescu
Aim: Activation of the sympathetic nervous system is common in resistant hypertension (RHT) and also in chronic kidney disease (CKD), a prevalent condition among resistant hypertensives. However, renal nerve ablation lowers blood pressure (BP) only in some patients with RHT. The influence of loss of nephrons per se on the antihypertensive response to renal denervation (RDNx) is unclear and was the focus of this study. Methods: Systemic hemodynamics and sympathetically mediated low frequency oscillations of systolic BP were determined continuously from telemetrically acquired BP recordings in rats before and after surgical excision of ∼80% of renal mass and subsequent RDNx...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29749404/endogenous-hepcidin-synthesis-protects-the-distal-nephron-against-hemin-and-hemoglobin-mediated-necroptosis
#9
Rachel P L van Swelm, Madelon Vos, Frank Verhoeven, Frank Thévenod, Dorine W Swinkels
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p < 0.001) in mice repeatedly injected with intravenous Hb. Moreover, the hepcidin induction was associated with a decline in urinary kidney injury markers 24p3/NGAL and KIM1, suggesting a role for hepcidin in protection against Hb kidney injury...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29737520/na-restriction-activates-enac-in-rat-kidney-through-two-mechanisms-and-decreases-distal-na-delivery
#10
Gustavo Frindt, Lei Yang, Krister Bamberg, Lawrence G Palmer
KEY POINTS: Dietary Na restriction, through the mineralocorticoid aldosterone, acts on epithelial Na channels (ENaC) through both fast (24 hrs) and slow (5 to 7 days) mechanisms in the kidney. The fast effect entails increased proteolytic processing and trafficking of channel protein to the apical membrane. It is rapidly reversible by the mineralocorticoid receptor antagonist eplerenone and is largely lost when tubules are studied ex vivo. The slow effect does not require increased processing or surface expression, is refractory to acute eplerenone treatment, and is preserved ex vivo...
May 8, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29733801/evaluation-of-renal-tumors-in-children
#11
Gülçin Bozlu, Elvan Çağlar Çıtak
OBJECTIVE: Renal tumors are not uncommon in children. In this study, we aimed to evaluate the clinical and pathological features of renal tumors in children. MATERIAL AND METHODS: Between January 2008 and December 2017, the records of children with renal tumors in our institution were retrospectively analyzed. Data collected were composed of demographic and clinical characteristics including gender, age at time of diagnosis, symptoms, laterality of the tumor and pathological evaluation...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732207/oncological-and-functional-efficacy-of-nephron-sparing-surgery-versus-radical-nephrectomy-in-renal-cell-carcinoma-stages-%C3%A2-ct1b-a-single-institution-matched-analysis
#12
Ralf Veys, Firas Abdollah, Alberto Briganti, Maarten Albersen, Hein Van Poppel, Steven Joniau
Introduction: The purpose of this paper is to compare oncological outcomes of partial nephrectomy (PN) versus radical nephrectomy (RN) in renal cell carcinoma (RCC) clinical stages ≥T1b, in a retrospective propensity-score matched cohort of a high-volume, tertiary referral center. This paper also aims to compare renal function and complication rates between groups. Material and methods: Our single-institution RCC database was queried to select patients with clinical stages defined by tumor size (T), lymph nodes(N), and metastasis (M) scores of T1b-4 N0 M0, that underwent PN or RN between 2000 and 2014...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29723675/retroperitoneal-laparoscopic-nephron-sparing-surgery-for-large-renal-angiomyolipoma-our-technique-and-experience-a-case-series-of-41-patients
#13
Xin Liu, Xin Ma, Qiming Liu, Qingbo Huang, Xintao Li, Baojun Wang, Hongzhao Li, Xu Zhang
OBJECTIVES: To introduce a 'kidney priority' strategy in treating large renal angiomyolipoma (RAML) with retroperitoneal laparoscopic nephron sparing surgery (RLNSS). PATIENTS AND METHODS: From 2010 to 2017, 41 patients with large RAML underwent RLNSS. Distinguished from the standard practice, the kidney was preferentially mobilized and separated from the RAML. Subsequently, it was reconstructed. Finally, the RAML was resected from the perinephric fat. The perioperative variables, surgical technique and complications were reviewed...
April 30, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29723589/46-xy-denys-drash-syndrome-is-there-a-role-for-nephron-sparing-modalities-in-management-of-renal-masses-a-report-of-two-cases
#14
Amr Hodhod, Mohamed El-Sherbiny
Denys Drash Syndrome (DDS) is a combination of genital and urinary anomalies that mostly associated with renal and gonadal malignancies. We report 2 patients who presented with genital ambiguity and were diagnosed as 46XY DDS. Both patients had renal masses during follow up and underwent partial nephrectomy aiming to have transplant at older age.
April 30, 2018: Urology
https://www.readbyqxmd.com/read/29723587/duplex-ultrasound-guided-direct-percutaneous-management-of-pseudoaneurysm-of-branch-of-segmental-renal-artery-technique-and-its-outcome
#15
Kumar Manoj, Gaurav Garg, Deepak Nagathan, Sanjeev Kumar Verma, Neera Kohli, Santosh Kumar, Sant Kumar Pandey, Satya Narayan Sankhwar
OBJECTIVE: To describe the role of Duplex-Ultrasound Imaging (DUI) in prompt diagnosis of pseudoaneurysm (PSA) of a branch of the segmental renal artery (b-SRA) and evaluate outcomes of DUI directed percutaneous embolization. METHODS: Forty-five patients were referred to us for the management of intractable renal hematuria. 20 cases (44.44%) had developed PSA after nephrolithotomy. 12 cases (12.66%) had developed PSA after guided renal biopsies. 6 cases (13.33%) had developed PSA following road side trauma...
April 30, 2018: Urology
https://www.readbyqxmd.com/read/29723225/survival-outcomes-in-patients-with-large-%C3%A2-7cm-clear-cell-renal-cell-carcinomas-treated-with-nephron-sparing-surgery-versus-radical-nephrectomy-results-of-a-multicenter-cohort-with-long-term-follow-up
#16
M W W Janssen, J Linxweiler, S Terwey, S Rugge, C-H Ohlmann, F Becker, Ch Thomas, A Neisius, J W Thüroff, S Siemer, M Stöckle, F C Roos
BACKGROUND: Does the dogma of nephron sparing surgery (NSS) still stand for large renal masses? Available studies dealing with that issue are considerably biased often mixing imperative with elective indications for NSS and also including less malignant variants or even benign renal tumors. Here, we analyzed the oncological long-term outcomes of patients undergoing elective NSS or radical tumor nephrectomy (RN) for non-endophytic, large (≥7cm) clear cell renal carcinoma (ccRCC). METHODS: Prospectively acquired, clinical databases from two academic high-volume centers were screened for patients from 1980 to 2010...
2018: PloS One
https://www.readbyqxmd.com/read/29719341/renal-cell-carcinoma-in-renal-allograft-case-series-and-review-of-literature
#17
Gaurav Vasisth, Anil Kapoor, Kevin Piercey, Shahid Lambe
Renal cell carcinoma (RCC) in transplanted kidneys has been reported sporadically with incidence of about 0.5%. There are currently no standard guidelines on the management of allograft RCC in renal transplant recipients. Our objective was to study effectiveness of nephron-sparing surgery (NSS) for allograft RCC. We performed a retrospective analysis of patients with RCC in renal allografts managed with NSS in our institution from January 2000 to December 2015. Patient demographics, interval between transplant and RCC diagnosis, operative parameters, perioperative complications, final pathology, and renal function were evaluated...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29715137/nephrometry-scores-the-effect-of-imaging-on-routine-read-out-and-prediction-of-outcome-of-nephron-sparing-surgery
#18
Jula Wadle, Svetlana Hetjens, Judith Winter, Julia Mühlbauer, Manuel Neuberger, Frank Waldbillig, Frederik Wessels, Niklas Westhoff, Philipp Riffel, Nina Wagener, Patrick Honeck, Maximilian Christian Kriegmair
BACKGROUND/AIM: This study investigated the impact of available preoperative imaging on the reliability and predictive accuracy of RENAL and PADUA nephrometry-scoring systems for renal tumors. PATIENTS AND METHODS: Five urologists determined RENAL and PADUA scores using preoperative imaging data (computed tomography and magnetic resonance imaging) of 100 patients admitted for partial nephrectomy with the following combinations: T0: transverse planes without excretory phase (EP), TC0: transverse and coronal planes without EP, TC1: transverse and coronal planes with EP...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713053/first-line-renin-angiotensin-system-inhibitors-vs-other-first-line-antihypertensive-drug-classes-in-hypertensive-patients-with-type-2-diabetes-mellitus
#19
Ganmi Wang, Yujie Chen, Liangjin Li, Wenlu Tang, James M Wright
First-line renin-angiotensin system (RAS) inhibitors are recommended for diabetic patients because of their potential nephron-protective properties. For hypertensive patients with type 2 diabetes mellitus, little is known about first-line RAS inhibitors vs. other first-line antihypertensive agents in terms of cardiovascular outcomes. We performed a meta-analysis of randomized controlled trials (RCTs) to assess the comparative efficacy of first-line RAS inhibitors vs. other first-line antihypertensive drug classes in hypertensive patients with type 2 diabetes mellitus...
May 1, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29712641/histone-deacetylases-1-and-2-regulate-the-transcriptional-programs-of-nephron-progenitors-and-renal-vesicles
#20
Hongbing Liu, Shaowei Chen, Xiao Yao, Yuwen Li, Chao-Hui Chen, Jiao Liu, Zubaida Saifudeen, Samir S El-Dahr
Nephron progenitor cells (NPC) are Six2-positive metanephric mesenchyme cells, which undergo self-renewal and differentiation to give rise to nephrons until the end of nephrogenesis. HDACs are a group of epigenetic regulators that control cell fate but their role in balancing NPC renewal and differentiation is unknown. Here, we report that NPC-specific deletion of HDAC1 and HDAC2 genes in mice results in early postnatal lethality due to renal hypo-dysplasia and loss of NPC. HDAC1/2 interact with the NPC renewal regulators Six2, Osr1 and Sall1, and are co-bound along with Six2 on the Six2 enhancer...
April 30, 2018: Development
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