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https://www.readbyqxmd.com/read/28966197/reducing-risks-associated-with-negative-pressure-wound-therapy-strategies-for-clinical-practice
#1
Elizabeth Andersson Mattox
Negative-pressure wound therapy represents a relatively new strategy for wound management. Significant, life-threatening complications (bleeding, infection, and retained dressing material) have been associated with negative-pressure wound therapy. As a result, the Food and Drug Administration published several warnings to negative-pressure wound therapy users and recommended that clinicians ordering, managing, and/or monitoring negative-pressure wound therapy be aware of the potential complications and be prepared to take prompt action to reduce patients' risk for harm...
October 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28947422/pd-1-expression-in-head-and-neck-squamous-cell-carcinomas-derives-primarily-from-functionally-anergic-cd4-tils-in-the-presence-of-pd-l1-tams
#2
Austin Mattox, Jina Lee, William H Westra, Robert H Pierce, Ronald Ghossein, William C Faquin, Thomas J Diefenbach, Luc Gt Morris, Derrick T Lin, Lori J Wirth, Armida Lefranc-Torres, Eiichi Ishida, Patrick D Chakravarty, Lauren Johnson, Yang Zeng, Huabiao Chen, Mark C Poznansky, Neil M Iyengar, Sara I Pai
Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of PD-1-based immune checkpoint therapy that is being explored widely in head and neck cancers. Using multispectral imaging, we systematically investigated the OTSCC tumor microenvironment (TME) by evaluating the frequency of PD-1 expression in CD8+, CD4+ and FoxP3+ tumor-infiltrating lymphocytes (TIL). We also defined the cellular sources of PD-L1 to evaluate the utility of PD-1:PD-L1 blocking antibody therapy in this patient population...
September 25, 2017: Cancer Research
https://www.readbyqxmd.com/read/28900524/distal-intersection-syndrome-progressing-to-extensor-pollicis-longus-tendon-rupture-a-case-report-with-sonographic-findings
#3
Ross Mattox, Patrick J Battaglia, Frank Scali, Kathy Ottolini, Norman W Kettner
The purpose of this case report is to describe the value of musculoskeletal ultrasound (US) in diagnosing both distal intersection syndrome (DIS) and rupture of the extensor pollicis longus (EPL) tendon in the same patient. A 38-year-old female presented for evaluation of a painful bump of unknown etiology on the dorsolateral aspect of her non-dominant wrist. US demonstrated tenosynovitis distal to Lister's tubercle of the EPL and extensor carpi radialis tendon sheaths, consistent with DIS. Immobilization therapy was employed, during which time the patient suffered rupture of the EPL tendon...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28825869/cancer-cachexia-cause-diagnosis-and-treatment
#4
Todd W Mattox
Patients with cancer frequently experience unintended weight loss due to gastrointestinal (GI) dysfunction caused by the malignancy or treatment of the malignancy. However, others may present with weight loss related to other symptoms not clearly associated with identifiable GI dysfunction such as anorexia and early satiety. Cancer cachexia (CC) is a multifactorial syndrome that is generally characterized by ongoing loss of skeletal muscle mass with or without fat loss, often accompanied by anorexia, weakness, and fatigue...
October 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28822212/comparison-of-start-and-salt-triage-methodologies-to-reference-standard-definitions-and-to-a-field-mass-casualty-simulation
#5
Salvatore Silvestri, Adam Field, Neal Mangalat, Tory Weatherford, Christopher Hunter, Zoe McGowan, Zachary Stamile, Trevor Mattox, Tanner Barfield, Aarian Afshari, George Ralls, Linda Papa
OBJECTIVES: We compared Sort, Assess, Lifesaving Intervention, Treatment/Transport (SALT) and Simple Triage and Rapid Treatment (START) triage methodologies to a published reference standard, and evaluated the accuracy of the START method applied by emergency medical services (EMS) personnel in a field simulation. DESIGN: Simulated mass casualty incident (MCI). Paramedics trained in START triage assigned each victim to green (minimal), yellow (delayed), red (immediate), or black (dead) categories...
January 2017: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28550191/the-level-of-deletion-17p-and-bi-allelic-inactivation-of-tp53-has-a-significant-impact-on-clinical-outcome-in-multiple-myeloma
#6
Sharmilan Thanendrarajan, Erming Tian, Pingping Qu, Pankaj Mathur, Carolina Schinke, Frits van Rhee, Maurizio Zangari, Leo Rasche, Niels Weinhold, Daisy Alapat, William Bellamy, Cody Ashby, Sandra Mattox, Joshua Epstein, Shmuel Yaccoby, Bart Barlogie, Antje Hoering, Michael Bauer, Brian A Walker, Faith E Davies, Gareth J Morgan
No abstract text is available yet for this article.
May 26, 2017: Haematologica
https://www.readbyqxmd.com/read/28515857/contrast-use-in-relation-to-the-arterial-access-site-for-percutaneous-coronary-intervention-a-comprehensive-meta-analysis-of-randomized-trials
#7
Rahman Shah, Anthony Mattox, M Rehan Khan, Chalak Berzingi, Abdul Rashid
AIM: To compare the amount of contrast used during percutaneous coronary intervention (PCI) via trans-radial access (TRA) vs trans-femoral access (TFA). METHODS: Scientific databases and websites were searched for:randomizedcontrolledtrials (RCTs). Data were extracted by two independent reviewers and was summarized as the weighted mean difference (WMD) of contrast used with a 95%CI using a random-effects model. RESULTS: The meta-analysis included 13 RCTs with a total of 3165 patients...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28489996/cancer-associated-mutations-in-endometriosis-without-cancer
#8
Michael S Anglesio, Nickolas Papadopoulos, Ayse Ayhan, Tayyebeh M Nazeran, Michaël Noë, Hugo M Horlings, Amy Lum, Siân Jones, Janine Senz, Tamer Seckin, Julie Ho, Ren-Chin Wu, Vivian Lac, Hiroshi Ogawa, Basile Tessier-Cloutier, Rami Alhassan, Amy Wang, Yuxuan Wang, Joshua D Cohen, Fontayne Wong, Adnan Hasanovic, Natasha Orr, Ming Zhang, Maria Popoli, Wyatt McMahon, Laura D Wood, Austin Mattox, Catherine Allaire, James Segars, Christina Williams, Cristian Tomasetti, Niki Boyd, Kenneth W Kinzler, C Blake Gilks, Luis Diaz, Tian-Li Wang, Bert Vogelstein, Paul J Yong, David G Huntsman, Ie-Ming Shih
BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted sequencing (3 patients)...
May 11, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28416672/bisulfite-converted-duplexes-for-the-strand-specific-detection-and-quantification-of-rare-mutations
#9
Austin K Mattox, Yuxuan Wang, Simeon Springer, Joshua D Cohen, Srinivasan Yegnasubramanian, William G Nelson, Kenneth W Kinzler, Bert Vogelstein, Nickolas Papadopoulos
The identification of mutations that are present at low frequencies in clinical samples is an essential component of precision medicine. The development of molecular barcoding for next-generation sequencing has greatly enhanced the sensitivity of detecting such mutations by massively parallel sequencing. However, further improvements in specificity would be useful for a variety of applications. We herein describe a technology (BiSeqS) that can increase the specificity of sequencing by at least two orders of magnitude over and above that achieved with molecular barcoding and can be applied to any massively parallel sequencing instrument...
May 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28381624/eye-development-in-the-four-eyed-fish-anableps-anableps-cranial-and-retinal-adaptations-to-simultaneous-aerial-and-aquatic-vision
#10
Louise N Perez, Jamily Lorena, Carinne M Costa, Maysa S Araujo, Gabriela N Frota-Lima, Gabriel E Matos-Rodrigues, Rodrigo A P Martins, George M T Mattox, Patricia N Schneider
The unique eyes of the four-eyed fish Anableps anableps have long intrigued biologists. Key features associated with the bulging eye of Anableps include the expanded frontal bone and the duplicated pupils and cornea. Furthermore, the Anableps retina expresses different photoreceptor genes in dorsal and ventral regions, potentially associated with distinct aerial and aquatic stimuli. To gain insight into the developmental basis of the Anableps unique eye, we examined neurocranium and eye ontogeny, as well as photoreceptor gene expression during larval stages...
April 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28365664/complications-of-peripheral-venous-access-devices-prevention-detection-and-recovery-strategies
#11
Elizabeth A Mattox
Most hospitalized patients have placement of a peripheral venous access device, either a short peripheral catheter or a peripherally inserted central catheter. Compared with central venous catheters that are not peripherally inserted, the other 2 types are generally perceived by health care providers as safer and less complicated to manage, and less emphasis is placed on the prevention and management of complications. Expertise of nurses in inserting, managing, and removing these devices may reduce the likelihood of complications, and increased recognition of complications associated with use of the devices is important to ensure continued improvements in the safety, quality, and efficiency of health care...
April 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28350269/review-of-a-single-surgeon-s-stapedotomy-cases-performed-with-a-nickel-titanium-prosthesis-over-a-14-year-period
#12
Natalie Justicz, Kaitlyn F Strickland, Kevin K Motamedi, Douglas E Mattox
CONCLUSION: Stapes surgery with a nickel titanium prosthesis is a safe and well-tolerated procedure that leads to a significant improvement in hearing outcomes. OBJECTIVE: To identify the efficacy and safety of stapedotomy procedures performed with a nickel titanium prosthesis for patients with otosclerosis. METHODS: A review of 431 unique stapedotomies performed over 14 years by a single surgeon at an academic tertiary care center yielded 312 cases with nickel titanium prosthesis that met inclusion criteria of otosclerosis diagnosis, initial surgery in operative ear, and presence of pre-operative and post-operative audiograms...
April 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28327294/reference-values-for-the-scalene-interval-width-during-varying-degrees-of-glenohumeral-abduction-using-ultrasonography
#13
Ross Mattox, Patrick J Battaglia, Aaron B Welk, Yumi Maeda, Daniel W Haun, Norman W Kettner
OBJECTIVE: The aim of this study was to establish reference values for the width of the interval between the anterior and middle scalene muscles using ultrasonography during varying degrees of glenohumeral joint (GH) abduction. Reliability and body mass index (BMI) data were also assessed. METHODS: Interscalene triangles of asymptomatic participants were scanned bilaterally in the transverse plane. Images were obtained at 0°, 90°, and 150° of GH abduction with the participant seated...
November 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28284432/the-seven-attributes-of-the-academic-surgeon-critical-aspects-of-the-archetype-and-contributions-to-the-surgical-community
#14
Todd K Rosengart, Meredith C Mason, Scott A LeMaire, Mary L Brandt, Joseph S Coselli, Steven A Curley, Kenneth L Mattox, Joseph L Mills, David J Sugarbaker, David A Berger
BACKGROUND: "Academic surgeon" describes a member of a medical school department of surgery, but this term does not fully define the important role of such physician-scientists in advancing surgical science through translational research and innovation. METHODS: The curriculum vitae and self-descriptive vignettes of the records of achievement of seven surgeons possessing documented records of academic leadership, innovation, and dissemination of knowledge were reviewed...
August 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28173466/book-review-clinical-otology-fourth-edition
#15
Douglas E Mattox
No abstract text is available yet for this article.
June 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28115404/concurrent-pityriasis-rosea-and-bell-s-palsy
#16
Vanessa Voss, Adam Mattox, Mary Guo
Pityriasis rosea is a dermatological disease with a well-documented clinical appearance, but less is known about causes and treatment. Bell's palsy is a neurological condition leading to acute idiopathic hemifacial paralysis. Recent studies indicate that human herpesvirus (HHV) 6-7 reactivation may be a contributing factor to both conditions. We report a case of the 2 concurrent diagnoses that supports a common contributing factor and suggests further awareness and research into the role HHV 6-7 may play in the aetiology of both conditions...
January 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/27977293/development-of-a-sleep-telementorship-program-for-rural-department-of-veterans-affairs-primary-care-providers-sleep-veterans-affairs-extension-for-community-healthcare-outcomes
#17
Elizabeth C Parsons, Elizabeth A Mattox, Lauren A Beste, David H Au, Bessie A Young, Michael F Chang, Brian N Palen
RATIONALE: Primary care providers (PCPs) frequently encounter sleep complaints, especially in regions with limited specialty care access. OBJECTIVES: The U.S. Department of Veterans Affairs Extension for Community Healthcare Outcomes (VA-ECHO) program (based on Project ECHO) has successfully provided rural PCP education in subspecialty areas, including hepatitis C. We describe the feasibility of an ECHO program for sleep medicine. METHODS: ECHO creates a virtual learning community through video-teleconferencing, combining didactics with individualized clinical case review...
February 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27884263/non-weight-bearing-and-weight-bearing-ultrasonography-of-select-foot-muscles-in-young-asymptomatic-participants-a-descriptive-and-reliability-study
#18
Patrick J Battaglia, Ross Mattox, Brett Winchester, Norman W Kettner
OBJECTIVE: The primary aim of this study was to determine the reliability of diagnostic ultrasound imaging for select intrinsic foot muscles using both non-weight-bearing and weight-bearing postures. Our secondary aim was to describe the change in muscle cross-sectional area (CSA) and dorsoplantar thickness when bearing weight. METHODS: An ultrasound examination was performed with a linear ultrasound transducer operating between 9 and 12 MHz. Long-axis and short-axis ultrasound images of the abductor hallucis, flexor digitorum brevis, and quadratus plantae were obtained in both the non-weight-bearing and weight-bearing postures...
November 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27879382/veteran-preferences-regarding-wireless-management-of-positive-airway-pressure-for-obstructive-sleep-apnea-at-a-tertiary-health-care-system
#19
Ken He, Brian N Palen, Elizabeth A Mattox, Elizabeth C Parsons
BACKGROUND: Timely monitoring of obstructive sleep apnea (OSA) therapy can be a challenge amid conflicting pressures of rising patient volume and shortage of sleep medicine providers. Positive airway pressure (PAP) devices with wireless modem technology have the potential to improve patient access to care and streamline work load, yet little is known about patient attitudes toward telehealth integration among veterans with sleep apnea. As part of a larger quality improvement initiative at the Veterans Affairs (VA) Puget Sound Health Care System, we elicited veterans' preferences toward modem versus traditional PAP data download, including patient attitudes and factors affecting those preferences...
March 2017: Respiratory Care
https://www.readbyqxmd.com/read/27831514/diagnostic-challenges-in-a-case-of-igg4-rd-affecting-the-temporal-bone
#20
Jackson Ross Vuncannon, Nicholas John Panella, Kelly R Magliocca, Douglas E Mattox
INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is a recently described fibroinflammatory condition with a characteristic histology. While IgG4-RD can affect a great variety of anatomical sites, it has been seldom described in the temporal bone. METHODS: Herein, a case IgG4-RD occurring in the temporal bone of a 35-year-old woman is reported. DISCUSSION: This case of IgG4-RD of the temporal bone proved a uniquely challenging diagnosis due to slightly atypical histology falling outside of "highly suggestive" criteria...
March 2017: Annals of Otology, Rhinology, and Laryngology
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