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https://www.readbyqxmd.com/read/27884263/non-weight-bearing-and-weight-bearing-ultrasonography-of-select-foot-muscles-in-young-asymptomatic-participants-a-descriptive-and-reliability-study
#1
Patrick J Battaglia, Ross Mattox, Brett Winchester, Norman W Kettner
OBJECTIVE: The primary aim of this study was to determine the reliability of diagnostic ultrasound imaging for select intrinsic foot muscles using both non-weight-bearing and weight-bearing postures. Our secondary aim was to describe the change in muscle cross-sectional area (CSA) and dorsoplantar thickness when bearing weight. METHODS: An ultrasound examination was performed with a linear ultrasound transducer operating between 9 and 12 MHz. Long-axis and short-axis ultrasound images of the abductor hallucis, flexor digitorum brevis, and quadratus plantae were obtained in both the non-weight-bearing and weight-bearing postures...
November 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27879382/veteran-preferences-regarding-wireless-management-of-positive-airway-pressure-for-obstructive-sleep-apnea-at-a-tertiary-health-care-system
#2
Ken He, Brian N Palen, Elizabeth A Mattox, Elizabeth C Parsons
BACKGROUND: Timely monitoring of obstructive sleep apnea (OSA) therapy can be a challenge amid conflicting pressures of rising patient volume and shortage of sleep medicine providers. Positive airway pressure (PAP) devices with wireless modem technology have the potential to improve patient access to care and streamline work load, yet little is known about patient attitudes toward telehealth integration among veterans with sleep apnea. As part of a larger quality improvement initiative at the Veterans Affairs (VA) Puget Sound Health Care System, we elicited veterans' preferences toward modem versus traditional PAP data download, including patient attitudes and factors affecting those preferences...
November 22, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27831514/diagnostic-challenges-in-a-case-of-igg4-rd-affecting-the-temporal-bone
#3
Jackson Ross Vuncannon, Nicholas John Panella, Kelly R Magliocca, Douglas E Mattox
INTRODUCTION: Immunoglobulin G4-related disease (IgG4-RD) is a recently described fibroinflammatory condition with a characteristic histology. While IgG4-RD can affect a great variety of anatomical sites, it has been seldom described in the temporal bone. METHODS: Herein, a case IgG4-RD occurring in the temporal bone of a 35-year-old woman is reported. DISCUSSION: This case of IgG4-RD of the temporal bone proved a uniquely challenging diagnosis due to slightly atypical histology falling outside of "highly suggestive" criteria...
November 9, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27818409/priming-the-physician-pipeline-a-regional-ahec-s-use-of-in-state-medical-school-data-to-guide-its-health-careers-programming
#4
David A Gross, Lainey C Mattox, Nicole Winkleman
Amid evidence of its rural, Appalachian students' low application and matriculation rates to in-state medical schools, the Northeast Kentucky Area Health Education Center developed two physician pipeline programs. This report describes the programs' early successes and provides a basis for heightened regional responsibility in the recruitment of medical school applicants.
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27506486/two-year-compass-trial-results-supraciliary-microstenting-with-phacoemulsification-in-patients-with-open-angle-glaucoma-and-cataracts
#5
Steven Vold, Iqbal Ike K Ahmed, E Randy Craven, Cynthia Mattox, Robert Stamper, Mark Packer, Reay H Brown, Tsontcho Ianchulev
PURPOSE: We evaluated 2-year safety and efficacy of supraciliary microstenting (CyPass Micro-Stent; Transcend Medical, Inc., Menlo Park, CA) for treating mild-to-moderate primary open-angle glaucoma (POAG) in patients undergoing cataract surgery. DESIGN: Multicenter (24 US sites), interventional randomized clinical trial (RCT) (ClinicalTrials.gov identifier, NCT01085357). PARTICIPANTS: Subjects were enrolled beginning July 2011, with study completion in March 2015...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27459545/high-specificity-in-circulating-tumor-cell-identification-is-required-for-accurate-evaluation-of-programmed-death-ligand-1
#6
Jennifer L Schehr, Zachery D Schultz, Jay W Warrick, David J Guckenberger, Hannah M Pezzi, Jamie M Sperger, Erika Heninger, Anwaar Saeed, Ticiana Leal, Kara Mattox, Anne M Traynor, Toby C Campbell, Scott M Berry, David J Beebe, Joshua M Lang
BACKGROUND: Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs) may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on accurate identification of CTCs from the diverse populations in the blood, where some tumor cells share characteristics with normal blood cells. While many blood cells can be excluded by their high expression of CD45, neutrophils and other immature myeloid subsets have low to absent expression of CD45 and also express PD-L1...
2016: PloS One
https://www.readbyqxmd.com/read/27330518/clinical-and-sonographic-evaluation-of-a-lower-extremity-angioleiomyoma-in-a-52-year-old-woman
#7
Ross Mattox, Aaron B Welk, Aimee Jokerst, Brooke Van Kirk, Norman W Kettner
OBJECTIVE: The purpose of this case study is to describe the role of sonographic examination in the initial evaluation of an angioleiomyoma and to discuss the characteristic findings associated with this soft tissue mass. CLINICAL FEATURES: A 52-year-old woman presented with a large, tender, erythematous mass on the anterolateral aspect of her right knee. Sonographic examination revealed a highly vascular mass within the subcutaneous tissues. Differential considerations included benign soft tissues masses such as angioleiomyoma and hemangioma...
June 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27298646/sonographic-diagnosis-of-an-acute-stener-lesion-a-case-report
#8
Ross Mattox, Aaron B Welk, Patrick J Battaglia, Frank Scali, Mero Nunez, Norman W Kettner
This case report describes the use of diagnostic ultrasound to diagnose a Stener lesion in a patient who presented for conservative care of thumb pain following a fall on an outstretched hand. Conventional radiographic images demonstrated an avulsion fracture at the ulnar aspect of the base of the first proximal phalanx. Diagnostic ultrasound revealed a torn ulnar collateral ligament of the thumb that was displaced proximal to the adductor aponeurosis, consistent with a Stener lesion. Dynamic imaging with ultrasound confirmed displacement of the fully torn ligament...
2016: Journal of Ultrasound
https://www.readbyqxmd.com/read/27153044/z-plasty-for-alar-groove-correction
#9
Joseph R Kallini, Adam R Mattox, Ian A Maher
No abstract text is available yet for this article.
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27132513/tnf-%C3%AE-modulates-genome-wide-redistribution-of-%C3%AE-np63%C3%AE-tap73-and-nf-%C3%AE%C2%BAb-crel-interactive-binding-on-tp53-and-ap-1-motifs-to-promote-an-oncogenic-gene-program-in-squamous-cancer
#10
H Si, H Lu, X Yang, A Mattox, M Jang, Y Bian, E Sano, H Viadiu, B Yan, C Yau, S Ng, S K Lee, R-A Romano, S Davis, R L Walker, W Xiao, H Sun, L Wei, S Sinha, C C Benz, J M Stuart, P S Meltzer, C Van Waes, Z Chen
The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs comodulated by cREL/ΔNp63/TAp73 transcription factors we uncovered in head and neck squamous cell carcinomas (HNSCCs). However, how inflammatory gene signatures and cREL/p63/p73 targets are comodulated genome wide is unclear...
November 3, 2016: Oncogene
https://www.readbyqxmd.com/read/27041432/deep-division-in-the-chlorophyceae-chlorophyta-revealed-by-chloroplast-phylogenomic-analyses-1
#11
Monique Turmel, Jean-Simon Brouard, Cédric Gagnon, Christian Otis, Claude Lemieux
The Chlorophyceae (sensu Mattox and Stewart) is a morphologically diverse class of the Chlorophyta displaying biflagellate and quadriflagellate motile cells with varying configurations of the flagellar apparatus. Phylogenetic analyses of 18S rDNA data and combined 18S and 26S rDNA data from a broad range of chlorophycean taxa uncovered five major monophyletic groups (Chlamydomonadales, Sphaeropleales, Oedogoniales, Chaetophorales, and Chaetopeltidales) but could not resolve their branching order. To gain insight into the interrelationships of these groups, we analyzed multiple genes encoded by the chloroplast genomes of Chlamydomonas reinhardtii P...
June 2008: Journal of Phycology
https://www.readbyqxmd.com/read/27039867/distribution-morphology-and-phylogeny-of-klebsormidium-klebsormidiales-charophyceae-in-urban-environments-in-europe-1
#12
Fabio Rindi, Michael D Guiry, Juan M López-Bautista
Klebsormidium is a cosmopolitan genus of green algae, widespread in terrestrial and freshwater habitats. The classification of Klebsormidium is entirely based on morphological characters, and very little is understood about its phylogeny at the species level. We investigated the diversity and phylogenetic relationships of Klebsormidium in urban habitats in Europe by a combination of approaches including examination of field-collected material, culture experiments conducted in many different combinations of factors, and phylogenetic analyses of the rbcL gene...
December 2008: Journal of Phycology
https://www.readbyqxmd.com/read/27030777/phenotypic-differences-between-the-sexes-in-the-sexually-plastic-mangrove-rivulus-fish-kryptolebias-marmoratus
#13
Mark J Garcia, Jack M Ferro, Tyler Mattox, Sydney Kopelic, Kristine Marson, Ryan Jones, Jon C Svendsen, Ryan L Earley
To maximize reproductive success, many animal species have evolved functional sex change. Theory predicts that transitions between sexes should occur when the fitness payoff of the current sex is exceeded by the fitness payoff of the opposite sex. We examined phenotypic differences between the sexes in a sex-changing vertebrate, the mangrove rivulus fish (Kryptolebias marmoratus), to elucidate potential factors that might drive the 'decision' to switch sex. Rivulus populations consist of self-fertilizing hermaphrodites and males...
April 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27015578/intraoperative-hypotensive-resuscitation-for-patients-undergoing-laparotomy-or-thoracotomy-for-trauma-early-termination-of-a-randomized-prospective-clinical-trial
#14
Matthew M Carrick, Catherine Anne Morrison, Nicole M Tapia, Jan Leonard, James W Suliburk, Michael A Norman, Francis J Welsh, Bradford G Scott, Kathy R Liscum, Sally R Raty, Matthew J Wall, Kenneth L Mattox
BACKGROUND: Hemorrhagic shock is responsible for one third of trauma related deaths. We hypothesized that intraoperative hypotensive resuscitation would improve survival for patients undergoing operative control of hemorrhage following penetrating trauma. METHODS: Between July 1, 2007, and March 28, 2013, penetrating trauma patients aged 14 years to 45 years with a systolic blood pressure of 90 mm Hg or lower requiring laparotomy or thoracotomy for control of hemorrhage were randomized 1:1 based on a target minimum mean arterial pressure (MAP) of 50 mm Hg (experimental arm, LMAP) or 65 mm Hg (control arm, HMAP)...
June 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26959098/primary-care-team-members-report-greater-individual-benefits-from-long-versus-short-term-specialty-telemedicine-mentorship
#15
Lauren A Beste, Elizabeth A Mattox, Raimund Pichler, Bessie A Young, David H Au, Susan F Kirsh, Maureen W Germani, Ashley Hedeen, Bonnie K Harp, Michael F Chang
BACKGROUND: Primary care providers who participate in structured specialty telemedicine mentorship report improvements in clinical content mastery, professional satisfaction, and specialist communication. INTRODUCTION: Although these programs require investments of infrastructure resources and time, the duration of participation required to accrue optimal benefits is not known. We aimed to assess whether duration of participation is related to improved benefits of a longitudinal telemedicine-based mentorship program, specifically regarding perceived specialty care access, acquisition of new knowledge and skills, team integration, and overall job satisfaction...
August 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/26878278/spontaneous-defects-between-the-mastoid-and-posterior-cranial-fossa
#16
Shruthi K Rereddy, Douglas E Mattox
Conclusions Spontaneous defects between the mastoid and the posterior cranial fossa are exceedingly rare. Patients with these lesions may have a lower BMI compared to those with middle cranial fossa encephaloceles, but are otherwise demographically similar. This study recommends repair via a transtemporal approach to allow for examination of the entire posterior face of the temporal bone. Objective To describe cases of spontaneous posterior cranial fossa defects. Methods This study reviewed all cases of spontaneous posterior fossa defects presenting to a tertiary referral center over the last decade and described clinical presentation, imaging, operative findings, and outcomes...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26842686/oritavancin-a-novel-lipoglycopeptide
#17
REVIEW
Jacob Mattox, Paul Belliveau, Cheryl Durand
OBJECTIVE: To review the pharmacology, pharmacokinetics, drug interactions, microbiologic profile, dosage and administration, safety, clinical efficacy, and potential place in therapy for the new lipoglycopetide, oritavancin. DATA SOURCES: MEDLINE and PubMed searches of available literature in English were conducted for oritavancin. Principal supplementary sources include the Food and Drug Administration (FDA) package insert, and FDA/European Medicines Agency guidances on acute bacterial skin and skin structure infections (ABSSSI)...
February 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/26840048/norman-e-mcswain-jr-md-facs-1937-2015
#18
Kenneth L Mattox
No abstract text is available yet for this article.
May 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26823390/ki-67-is-required-for-maintenance-of-cancer-stem-cells-but-not-cell-proliferation
#19
Justin Cidado, Hong Yuen Wong, D Marc Rosen, Ashley Cimino-Mathews, Joseph P Garay, Abigail G Fessler, Zeshaan A Rasheed, Jessica Hicks, Rory L Cochran, Sarah Croessmann, Daniel J Zabransky, Morassa Mohseni, Julia A Beaver, David Chu, Karen Cravero, Eric S Christenson, Arielle Medford, Austin Mattox, Angelo M De Marzo, Pedram Argani, Ajay Chawla, Paula J Hurley, Josh Lauring, Ben Ho Park
Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a proliferative disadvantage compared to wildtype controls in colony formation assays and displayed increased sensitivity to various chemotherapies. Ki-67 null cancer cells showed decreased and delayed tumor formation in xenograft assays, which was associated with a reduction in cancer stem cell markers...
February 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/26759151/identification-of-the-murine-h-2d-b-and-human-hla-a-0201-mhc-class-i-restricted-hpv6-e7-specific-cytotoxic-t-lymphocyte-epitopes
#20
Shiwen Peng, Austin Mattox, Simon R Best, Anca M Barbu, James A Burns, Belinda Akpeng, Jessica Jeang, Benjamin Yang, Eiichi Ishida, Chien-Fu Hung, Tzyy-Choou Wu, Sara I Pai
Recurrent respiratory papillomatosis is caused by human papillomavirus (HPV) infection, most commonly types 6 (HPV-6) and 11 (HPV-11). Due to failed host immune responses, HPV is unable to be cleared from the host, resulting in recurrent growth of HPV-related lesions that can obstruct the lumen of the airway within the upper aerodigestive tract. In our murine model, the HPV-6b and HPV-11 E7 antigens are not innately immunogenic. In order to enhance the host immune responses against the HPV E7 antigen, we linked calreticulin (CRT) to HPV-6b E7 and found that vaccinating C57BL/6 mice with the HPV-6b CRT/E7 DNA vaccine is able to induce a CD8+ T cell response that recognizes an H-2D(b)-restricted E7aa21-29 epitope...
March 2016: Cancer Immunology, Immunotherapy: CII
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