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Steven Vold, Iqbal Ike K Ahmed, E Randy Craven, Cynthia Mattox, Robert Stamper, Mark Packer, Reay H Brown, Tsontcho Ianchulev
PURPOSE: We evaluated 2-year safety and efficacy of supraciliary microstenting (CyPass Micro-Stent; Transcend Medical, Inc., Menlo Park, CA) for treating mild-to-moderate primary open-angle glaucoma (POAG) in patients undergoing cataract surgery. DESIGN: Multicenter (24 US sites), interventional randomized clinical trial (RCT) ( identifier, NCT01085357). PARTICIPANTS: Subjects were enrolled beginning July 2011, with study completion in March 2015...
October 2016: Ophthalmology
Jennifer L Schehr, Zachery D Schultz, Jay W Warrick, David J Guckenberger, Hannah M Pezzi, Jamie M Sperger, Erika Heninger, Anwaar Saeed, Ticiana Leal, Kara Mattox, Anne M Traynor, Toby C Campbell, Scott M Berry, David J Beebe, Joshua M Lang
BACKGROUND: Expression of programmed-death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC) is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs) may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on accurate identification of CTCs from the diverse populations in the blood, where some tumor cells share characteristics with normal blood cells. While many blood cells can be excluded by their high expression of CD45, neutrophils and other immature myeloid subsets have low to absent expression of CD45 and also express PD-L1...
2016: PloS One
Ross Mattox, Aaron B Welk, Aimee Jokerst, Brooke Van Kirk, Norman W Kettner
OBJECTIVE: The purpose of this case study is to describe the role of sonographic examination in the initial evaluation of an angioleiomyoma and to discuss the characteristic findings associated with this soft tissue mass. CLINICAL FEATURES: A 52-year-old woman presented with a large, tender, erythematous mass on the anterolateral aspect of her right knee. Sonographic examination revealed a highly vascular mass within the subcutaneous tissues. Differential considerations included benign soft tissues masses such as angioleiomyoma and hemangioma...
June 2016: Journal of Chiropractic Medicine
Ross Mattox, Aaron B Welk, Patrick J Battaglia, Frank Scali, Mero Nunez, Norman W Kettner
This case report describes the use of diagnostic ultrasound to diagnose a Stener lesion in a patient who presented for conservative care of thumb pain following a fall on an outstretched hand. Conventional radiographic images demonstrated an avulsion fracture at the ulnar aspect of the base of the first proximal phalanx. Diagnostic ultrasound revealed a torn ulnar collateral ligament of the thumb that was displaced proximal to the adductor aponeurosis, consistent with a Stener lesion. Dynamic imaging with ultrasound confirmed displacement of the fully torn ligament...
2016: Journal of Ultrasound
Joseph R Kallini, Adam R Mattox, Ian A Maher
No abstract text is available yet for this article.
June 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
H Si, H Lu, X Yang, A Mattox, M Jang, Y Bian, E Sano, H Viadiu, B Yan, C Yau, S Ng, S K Lee, R-A Romano, S Davis, R L Walker, W Xiao, H Sun, L Wei, S Sinha, C C Benz, J M Stuart, P S Meltzer, C Van Waes, Z Chen
The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs comodulated by cREL/ΔNp63/TAp73 transcription factors we uncovered in head and neck squamous cell carcinomas (HNSCCs). However, how inflammatory gene signatures and cREL/p63/p73 targets are comodulated genome wide is unclear...
May 2, 2016: Oncogene
Monique Turmel, Jean-Simon Brouard, Cédric Gagnon, Christian Otis, Claude Lemieux
The Chlorophyceae (sensu Mattox and Stewart) is a morphologically diverse class of the Chlorophyta displaying biflagellate and quadriflagellate motile cells with varying configurations of the flagellar apparatus. Phylogenetic analyses of 18S rDNA data and combined 18S and 26S rDNA data from a broad range of chlorophycean taxa uncovered five major monophyletic groups (Chlamydomonadales, Sphaeropleales, Oedogoniales, Chaetophorales, and Chaetopeltidales) but could not resolve their branching order. To gain insight into the interrelationships of these groups, we analyzed multiple genes encoded by the chloroplast genomes of Chlamydomonas reinhardtii P...
June 2008: Journal of Phycology
Fabio Rindi, Michael D Guiry, Juan M López-Bautista
Klebsormidium is a cosmopolitan genus of green algae, widespread in terrestrial and freshwater habitats. The classification of Klebsormidium is entirely based on morphological characters, and very little is understood about its phylogeny at the species level. We investigated the diversity and phylogenetic relationships of Klebsormidium in urban habitats in Europe by a combination of approaches including examination of field-collected material, culture experiments conducted in many different combinations of factors, and phylogenetic analyses of the rbcL gene...
December 2008: Journal of Phycology
Mark J Garcia, Jack M Ferro, Tyler Mattox, Sydney Kopelic, Kristine Marson, Ryan Jones, Jon C Svendsen, Ryan L Earley
To maximize reproductive success, many animal species have evolved functional sex change. Theory predicts that transitions between sexes should occur when the fitness payoff of the current sex is exceeded by the fitness payoff of the opposite sex. We examined phenotypic differences between the sexes in a sex-changing vertebrate, the mangrove rivulus fish (Kryptolebias marmoratus), to elucidate potential factors that might drive the 'decision' to switch sex. Rivulus populations consist of self-fertilizing hermaphrodites and males...
April 2016: Journal of Experimental Biology
Matthew M Carrick, Catherine Anne Morrison, Nicole M Tapia, Jan Leonard, James W Suliburk, Michael A Norman, Francis J Welsh, Bradford G Scott, Kathy R Liscum, Sally R Raty, Matthew J Wall, Kenneth L Mattox
BACKGROUND: Hemorrhagic shock is responsible for one third of trauma related deaths. We hypothesized that intraoperative hypotensive resuscitation would improve survival for patients undergoing operative control of hemorrhage following penetrating trauma. METHODS: Between July 1, 2007, and March 28, 2013, penetrating trauma patients aged 14 years to 45 years with a systolic blood pressure of 90 mm Hg or lower requiring laparotomy or thoracotomy for control of hemorrhage were randomized 1:1 based on a target minimum mean arterial pressure (MAP) of 50 mm Hg (experimental arm, LMAP) or 65 mm Hg (control arm, HMAP)...
June 2016: Journal of Trauma and Acute Care Surgery
Lauren A Beste, Elizabeth A Mattox, Raimund Pichler, Bessie A Young, David H Au, Susan F Kirsh, Maureen W Germani, Ashley Hedeen, Bonnie K Harp, Michael F Chang
BACKGROUND: Primary care providers who participate in structured specialty telemedicine mentorship report improvements in clinical content mastery, professional satisfaction, and specialist communication. INTRODUCTION: Although these programs require investments of infrastructure resources and time, the duration of participation required to accrue optimal benefits is not known. We aimed to assess whether duration of participation is related to improved benefits of a longitudinal telemedicine-based mentorship program, specifically regarding perceived specialty care access, acquisition of new knowledge and skills, team integration, and overall job satisfaction...
August 2016: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Shruthi K Rereddy, Douglas E Mattox
Conclusions Spontaneous defects between the mastoid and the posterior cranial fossa are exceedingly rare. Patients with these lesions may have a lower BMI compared to those with middle cranial fossa encephaloceles, but are otherwise demographically similar. This study recommends repair via a transtemporal approach to allow for examination of the entire posterior face of the temporal bone. Objective To describe cases of spontaneous posterior cranial fossa defects. Methods This study reviewed all cases of spontaneous posterior fossa defects presenting to a tertiary referral center over the last decade and described clinical presentation, imaging, operative findings, and outcomes...
2016: Acta Oto-laryngologica
Jacob Mattox, Paul Belliveau, Cheryl Durand
OBJECTIVE: To review the pharmacology, pharmacokinetics, drug interactions, microbiologic profile, dosage and administration, safety, clinical efficacy, and potential place in therapy for the new lipoglycopetide, oritavancin. DATA SOURCES: MEDLINE and PubMed searches of available literature in English were conducted for oritavancin. Principal supplementary sources include the Food and Drug Administration (FDA) package insert, and FDA/European Medicines Agency guidances on acute bacterial skin and skin structure infections (ABSSSI)...
February 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Kenneth L Mattox
No abstract text is available yet for this article.
May 2016: Journal of Trauma and Acute Care Surgery
Justin Cidado, Hong Yuen Wong, D Marc Rosen, Ashley Cimino-Mathews, Joseph P Garay, Abigail G Fessler, Zeshaan A Rasheed, Jessica Hicks, Rory L Cochran, Sarah Croessmann, Daniel J Zabransky, Morassa Mohseni, Julia A Beaver, David Chu, Karen Cravero, Eric S Christenson, Arielle Medford, Austin Mattox, Angelo M De Marzo, Pedram Argani, Ajay Chawla, Paula J Hurley, Josh Lauring, Ben Ho Park
Ki-67 expression is correlated with cell proliferation and is a prognostic marker for various cancers; however, its function is unknown. Here we demonstrate that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a proliferative disadvantage compared to wildtype controls in colony formation assays and displayed increased sensitivity to various chemotherapies. Ki-67 null cancer cells showed decreased and delayed tumor formation in xenograft assays, which was associated with a reduction in cancer stem cell markers...
February 2, 2016: Oncotarget
Shiwen Peng, Austin Mattox, Simon R Best, Anca M Barbu, James A Burns, Belinda Akpeng, Jessica Jeang, Benjamin Yang, Eiichi Ishida, Chien-Fu Hung, Tzyy-Choou Wu, Sara I Pai
Recurrent respiratory papillomatosis is caused by human papillomavirus (HPV) infection, most commonly types 6 (HPV-6) and 11 (HPV-11). Due to failed host immune responses, HPV is unable to be cleared from the host, resulting in recurrent growth of HPV-related lesions that can obstruct the lumen of the airway within the upper aerodigestive tract. In our murine model, the HPV-6b and HPV-11 E7 antigens are not innately immunogenic. In order to enhance the host immune responses against the HPV E7 antigen, we linked calreticulin (CRT) to HPV-6b E7 and found that vaccinating C57BL/6 mice with the HPV-6b CRT/E7 DNA vaccine is able to induce a CD8+ T cell response that recognizes an H-2D(b)-restricted E7aa21-29 epitope...
March 2016: Cancer Immunology, Immunotherapy: CII
Gregory L Skuta, Cynthia G Mattox, Joshua D Stein
No abstract text is available yet for this article.
February 2016: JAMA Ophthalmology
Martha Okafor, Glenda Wrenn, Victor Ede, Nana Wilson, William Custer, Emile Risby, Michael Claeys, Frank E Shelp, Hany Atallah, Gail Mattox, David Satcher
The goal of this study was to better integrate emergency medical and psychiatric care at a large urban public hospital, identify impact on quality improvement metrics, and reduce healthcare cost. A psychiatric fast track service was implemented as a quality improvement initiative. Data on disposition from the emergency department from January 2011 to May 2012 for patients impacted by the pilot were analyzed. 4329 patients from January 2011 to August 2011 (pre-intervention) were compared with 4867 patients from September 2011 to May 2012 (intervention)...
April 2016: Community Mental Health Journal
Patrick J Battaglia, Ross Mattox, Daniel W Haun, Aaron B Welk, Norman W Kettner
BACKGROUND: No detailed reports exist describing the methodology of ultrasound image acquisition of the deep external rotator muscles of the hip. Because gluteal pain and sciatica are common, ultrasound may be a useful dynamic imaging adjunct in the evaluation of these patients. OBJECTIVE: To describe dynamic ultrasonography of the deep external rotator muscles of the hip for diagnostic purposes. DESIGN: Descriptive. SETTING: University radiology department...
July 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Lalage A Katunga, Preeti Gudimella, Jimmy T Efird, Scott Abernathy, Taylor A Mattox, Cherese Beatty, Timothy M Darden, Kathleen A Thayne, Hazaim Alwair, Alan P Kypson, Jitka A Virag, Ethan J Anderson
[This corrects the article DOI: 10.1016/j.molmet.2015.04.001.].
October 2015: Molecular Metabolism
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