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https://www.readbyqxmd.com/read/28437990/silicon-mode-de-multiplexers-with-parameters-optimized-using-shortcuts-to-adiabaticity
#1
Defen Guo, Tao Chu
We propose and experimentally demonstrate broadband silicon mode (de)multiplexers based on the optimization of system adiabaticity using shortcuts to adiabaticity (STA). The measured insertion losses and crosstalks were less than 1.1 dB and -24 dB, respectively, for the five two-mode mode-division-multiplexing (MDM) links over wavelengths ranging from 1500 nm to 1600 nm. The four-mode MDM link showed measured insertion losses and crosstalks less than 1.3 dB and -23 dB, respectively, within the same wavelength range...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437925/back-contacted-basi-sub-2-sub-solar-cells-an-optical-study
#2
Robin Vismara, Olindo Isabella, Miro Zeman
We present the optical investigation of a novel back-contacted architecture for solar cells based on a thin barium (di)silicide (BaSi<sub>2</sub>) absorber. First, through the analysis of absorption limits of different semiconducting materials, we show the potential of BaSi<sub>2</sub> for photovoltaic applications. Then, the proposed back contacted BaSi<sub>2</sub> solar cell design is investigated and optimized. An implied photocurrent density of 40.3 mA/cm<sup>2</sup> in a 1-μm thick absorber was achieved, paving the way for novel BaSi<sub>2</sub>-based thin-film solar cells...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437700/nanomolar-electrochemical-detection-of-caffeic-acid-in-fortified-wine-samples-based-on-gold-palladium-nanoparticles-decorated-graphene-flakes
#3
Kokulnathan Thangavelu, Nehru Raja, Shen-Ming Chen, Wei-Cheng Liao
Amalgamation of noble metal nanomaterials on graphene flakes potentially paves one way to improve their physicochemical properties. This paper deals with the simultaneous electrochemical deposition of gold and palladium nanoparticles on graphene flakes (Au/PdNPs-GRF) for the sensitive determination of caffeic acid (CA). The physiochemical properties of the prepared Au/PdNPs-GRF was characterized by using numerous analytical techniques such as scanning electron microscopy, electron dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, Raman spectroscopy and electrochemical impedance spectroscopy...
April 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28437640/the-woven-fiber-organic-electrochemical-transistors-based-on-polypyrrole-nanowires-reduced-graphene-oxide-composites-for-glucose-sensing
#4
Yuedan Wang, Xing Qing, Quan Zhou, Yang Zhang, Qiongzhen Liu, Ke Liu, Wenwen Wang, Mufang Li, Zhentan Lu, Yuanli Chen, Dong Wang
Novel woven fiber organic electrochemical transistors based on polypyrrole (PPy) nanowires and reduced graphene oxide (rGO) have been prepared. SEM revealed that the introduction of rGO nanosheets could induce the growth and increase the amount of PPy nanowires. Moreover, it could enhance the electrical performance of fiber transistors. The hybrid transistors showed high on/off ratio of 10(2), fast switch speed, and long cycling stability. The glucose sensors based on the fiber organic electrochemical transistors have also been investigated, which exhibited outstanding sensitivity, as high as 0...
April 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28437528/automated-staging-of-age-related-macular-degeneration-using-optical-coherence-tomography
#5
Freerk G Venhuizen, Bram van Ginneken, Freekje van Asten, Mark J J P van Grinsven, Sascha Fauser, Carel B Hoyng, Thomas Theelen, Clara I Sánchez
Purpose: To evaluate a machine learning algorithm that automatically grades age-related macular degeneration (AMD) severity stages from optical coherence tomography (OCT) scans. Methods: A total of 3265 OCT scans from 1016 patients with either no signs of AMD or with signs of early, intermediate, or advanced AMD were randomly selected from a large European multicenter database. A machine learning system was developed to automatically grade unseen OCT scans into different AMD severity stages without requiring retinal layer segmentation...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28437187/synergy-between-choroid-plexus-epithelial-cells-conditioned-medium-and-knockout-serum-replacement-converts-human-adipose-derived-stem-cells-to-dopamine-secreting-neurons
#6
Mahdi Eskandarian Boroujeni, Mossa Gardaneh, Mehrnoosh Hasan Shahriari, Abbas Aliaghaei, Sanaz Hasani
Human adipose-derived stem cells (hADSCs) have great capacity to differentiate into mesodermal origins as well as non-mesodermal lineages including neural cells. This valuable feature paves the way for the therapeutic application of hADSCs for neurodegenerative maladies such as Parkinson's disease (PD). We tested the capacity of Choroid Plexus epithelial cells-conditioned medium (CPEC-CM) alone or cocktailed with knock-out serum (KS) to induce dopaminergic differentiation of hADSCs. To this end, hADSCs from lipoaspirate were phenotypically characterized and shown to maintain mesodermal multipotency so selected media easily differentiated them into osteoblasts, chondrocytes and adipocytes...
March 2, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28437097/total-syntheses-of-vancomycin-related-glycopeptide-antibiotics-and-key-analogues
#7
Akinori Okano, Nicholas A Isley, Dale L Boger
A review of efforts that have provided total syntheses of vancomycin and related glycopeptide antibiotics, their agylcons, and key analogues is provided. It is a tribute to developments in organic chemistry and the field of organic synthesis that not only can molecules of this complexity be prepared today by total synthesis but such efforts can be extended to the preparation of previously inaccessible key analogues that contain deep-seated structural changes. With the increasing prevalence of acquired bacterial resistance to existing classes of antibiotics and with the emergence of vancomycin-resistant pathogens (VRSA and VRE), the studies pave the way for the examination of synthetic analogues rationally designed to not only overcome vancomycin resistance but provide the foundation for the development of even more powerful and durable antibiotics...
April 24, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28437016/electromechanical-nanogenerator-cell-interaction-modulates-cell-activity
#8
Gonzalo Murillo, Andreu Blanquer, Carolina Vargas-Estevez, Lleonard Barrios, Elena Ibáñez, Carme Nogués, Jaume Esteve
Noninvasive methods for in situ electrical stimulation of human cells open new frontiers to future bioelectronic therapies, where controlled electrical impulses could replace the use of chemical drugs for disease treatment. Here, this study demonstrates that the interaction of living cells with piezoelectric nanogenerators (NGs) induces a local electric field that self-stimulates and modulates their cell activity, without applying an additional chemical or physical external stimulation. When cells are cultured on top of the NGs, based on 2D ZnO nanosheets, the electromechanical NG-cell interactions stimulate the motility of macrophages and trigger the opening of ion channels present in the plasma membrane of osteoblast-like cells (Saos-2) inducing intracellular calcium transients...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28437015/one-step-solution-phase-growth-of-transition-metal-dichalcogenide-thin-films-directly-on-solid-substrates
#9
Anupam Giri, Heeseung Yang, Kalianan Thiyagarajan, Woosun Jang, Jae Min Myoung, Ranbir Singh, Aloysius Soon, Kilwon Cho, Unyong Jeong
Ultrathin transition metal dichalcogenides (TMDs) have exotic electronic properties. With success in easy synthesis of high quality TMD thin films, the potential applications will become more viable in electronics, optics, energy storage, and catalysis. Synthesis of TMD thin films has been mostly performed in vacuum or by thermolysis. So far, there is no solution phase synthesis to produce large-area thin films directly on target substrates. Here, this paper reports a one-step quick synthesis (within 45-90 s) of TMD thin films (MoS2 , WS2 , MoSe2 , WSe2 , etc...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28436920/hybrid-3d-printing-and-electrodeposition-approach-for-controllable-3d-alginate-hydrogel-formation
#10
Wanfeng Shang, Yanting Liu, Wenfeng Wan, Chengzhi Hu, Zeyang Liu, Chin To Wong, Toshio Fukuda, Yajing Shen
Calcium alginate hydrogel is one of the most widely used biocompatible materials in biomedical and tissue engineering. This paper reports a hybrid 3D printing and electrodeposition approach to form the 3D calcium alginate hydrogel in a controllable manner. Firstly, a specific 3D printing system is developed by combining a 3D printer and a customized ejection syringe. Then, the mixed solution (1% w/v sodium alginate and 0.25% w/v CaCO3 nano particles) is filled in the syringe and ejected out from the nozzle to the substrate continuously...
April 24, 2017: Biofabrication
https://www.readbyqxmd.com/read/28436914/a-time-variant-log-linear-learning-approach-to-the-set-k-cover-problem-in-wireless-sensor-networks
#11
Changhao Sun
Toward the global optimality of the SET K-COVER problem in wireless sensor networks, we view each sensor node as a rational player and propose a time variant log-linear learning algorithm (TVLLA) that relies on local information only. By defining the local utility as the normalized area covered by one node alone, we formulate the problem as a spatial potential game. The resulting optimal Nash equilibria correspond to the optimal partition. Such equilibria are obtained by designing a time varying parameter β that approaches infinity with time...
April 19, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28436585/the-mobile-conjugate-reinforcement-paradigm-in-a-lab-setting
#12
Emily C Merz, Laraine McDonough, Yong Lin Huang, Sophie Foss, Elizabeth Werner, Catherine Monk
The mobile conjugate reinforcement task was administered to 4-month-old infants in a lab rather than a home setting where it is usually administered. Learning and retention patterns were comparable to those of infants tested in their homes, suggesting flexibility in where this task can be administered. These results pave the way for this task to be used with a broader range of infants for whom home visits are not practical or convenient (e.g., infants in child care). Developmental research conducted with a more diverse population of infants would facilitate our understanding of cognitive development very early in life...
April 24, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28436509/covering-the-optical-spectrum-through-collective-rare-earth-doping-of-nagdf4-nanoparticles-806-and-980-nm-excitation-routes
#13
A Skripka, R Marin, A Benayas, P Canton, E Hemmer, F Vetrone
Today, at the frontier of biomedical research, the need has been clearly established for integrating disease detection and therapeutic function in one single theranostic system. Light-emitting nanoparticles are being intensively investigated to fulfil this demand, by continuously developing nanoparticle systems simultaneously emitting in both the UV/visible (light-triggered release and activation of drugs) and the near-infrared (imaging and tracking) spectral regions. In this work, rare-earth (RE) doped nanoparticles (RENPs) were synthesized via a thermal decomposition process and spectroscopically investigated as potential candidates as all-in-one optical imaging, diagnostic and therapeutic agents...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28436451/empirical-modeling-of-physiochemical-immune-response-of-multilayer-zinc-oxide-nanomaterials-under-uv-exposure-to-melanoma-and-foreskin-fibroblasts
#14
Muhammad Fakhar-E-Alam, M Waseem Akram, Seemab Iqbal, K S Alimgeer, M Atif, K Sultana, M Willander, Zhiming M Wang
Carcinogenesis is a complex molecular process starting with genetic and epigenetic alterations, mutation stimulation, and DNA modification, which leads to proteomic adaptation ending with an uncontrolled proliferation mechanism. The current research focused on the empirical modelling of the physiological response of human melanoma cells (FM55P) and human foreskin fibroblasts cells (AG01518) to the multilayer zinc oxide (ZnO) nanomaterials under UV-A exposure. To validate this experimental scheme, multilayer ZnO nanomaterials were grown on a femtotip silver capillary and conjugated with protoporphyrin IX (PpIX)...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435104/drosophila-pink1-and-parkin-loss-of-function-mutants-display-a-range-of-non-motor-parkinson-s-disease-phenotypes
#15
Hannah Julienne, Edgar Buhl, David S Leslie, James J L Hodge
Parkinson's disease (PD) is more commonly associated with its motor symptoms and the related degeneration of dopamine (DA) neurons. However, it is becoming increasingly clear that PD patients also display a wide range of non-motor symptoms, including memory deficits and disruptions of their sleep-wake cycles. These have a large impact on their quality of life, and often precede the onset of motor symptoms, but their etiology is poorly understood. The fruit fly Drosophila has already been successfully used to model PD, and has been used extensively to study relevant non-motor behaviours in other contexts, but little attention has yet been paid to modelling non-motor symptoms of PD in this genetically tractable organism...
April 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28433795/helicobacter-pylori-cagl-amino-acid-polymorphism-d58e59-pave-the-way-toward-peptic-ulcer-disease-while-n58e59-is-associated-with-gastric-cancer-in-north-of-iran
#16
Mina Rezaee Cherati, Javad Shokri-Shirvani, Ahmad Karkhah, Ramzan Rajabnia, Hamid Reza Nouri
The cagL protein of Helicobacter pylori involving in pathogenesis of gastroduodenal disorders. Therefore, the current study was conducted to determine the cagL amino acid polymorphisms in patients with gastric diseases. One hundred gastric biopsies were collected from gastritis, peptic ulcer (PUD) and gastric cancer (GC) patients and were screened for cagL using polymerase chain reaction (PCR). Also, sequence variations of the cagL were assessed via sequence translation. The cagL geneopositivity was 71.6% in patients were infected with H...
April 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28432971/voids-padding-induced-further-enhancement-in-photocatalytic-performance-of-porous-graphene-like-carbon-nitride
#17
Guohui Dong, Dong Chen, Jianmin Luo, Yunqing Zhu, Yubin Zeng, Chuanyi Wang
Design of 2-Dimensional nanostructured photocatalyst is an effective way to improve the photocatalytic activity of its bulk counterpart. However, the remaining (or newborn) drawbacks, such as enlarged band gap and the surface recombination of photogenerated charge carries, extremely limited the practical application of nanosheeted photocatalysts in solar energy conversion. In this study, we demonstrated that the voids padding with NH4Cl can eliminate part of quantum size effect to reduce the band gap of nanosheeted carbon nitride...
April 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28432902/ayahuasca-s-entwined-efficacy-an-ethnographic-study-of-ritual-healing-from-addiction
#18
Piera Talin, Emilia Sanabria
BACKGROUND: A range of studies has demonstrated the efficacy of the psychoactive Amazonian brew ayahuasca in addressing substance addiction. These have revealed that physiological and psychological mechanisms are deeply enmeshed. This article focuses on how interactive ritual contexts support the healing effort. The study of psychedelic-assisted treatments for addiction has much to gain from ethnographic analyses of healing experiences within the particular ecologies of use and care, where these interventions are rendered efficacious...
April 19, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28432816/rhodnius-prolixus-from-classical-physiology-to-modern-developmental-biology
#19
REVIEW
Rodrigo Nunes-da-Fonseca, Mateus Berni, Vitória Tobias-Dos-Santos, Attilio Pane, Helena Marcolla Araujo
The hemiptera Rhodnius prolixus is a blood-feeding insect and a primary vector of Trypanosoma cruzi, the etiological agent of the Chagas disease. Over the past century, Rhodnius has been the subject of intense investigations, which have contributed to unveil important aspects of metabolism and physiology in insects. Recent technological innovations are helping dissect the genetic and molecular underpinnings of Rhodnius embryogenesis and organogenesis, thus fostering the use of this important species in the fields of developmental and evolutionary biology...
April 22, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28432378/advances-in-anti-viral-immune-defence-revealing-the-importance-of-the-ifn-jak-stat-pathway
#20
REVIEW
Nicola Raftery, Nigel J Stevenson
Interferon-alpha (IFN-α) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-α is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-α embarks upon a complex downstream signalling cascade called the JAK/STAT pathway. This signalling pathway results in the expression of hundreds of effector genes known as interferon stimulated genes (ISGs). These genes are the basis for an elaborate effector mechanism and ultimately, the clearance of viral infection...
April 21, 2017: Cellular and Molecular Life Sciences: CMLS
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