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Priyanka Sharma
Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and is associated with poor long-term outcomes compared to other breast cancer subtypes. Currently, chemotherapy remains the main modality of treatment for early-stage TNBC, as there is no approved targeted therapy for this subtype. The biologic heterogeneity of TNBC has hindered the development and evaluation of novel agents, but recent advancements in subclassifying TNBC have paved the way for further investigation of more effective systemic therapies, including cytotoxic and targeted agents...
April 14, 2018: Current Treatment Options in Oncology
Saeede Karbasforush, Alireza Nourazarian, Masoud Darabi, Reza Rahbarghazi, Fatemeh Khaki-Khatibi, Çıgır Biray Avci, Leila Salimi, Bakiye Goker Bagca, Tanaz Novin Bahador, Aysa Rezabakhsh, Majid Khaksar
Abnormal activity of atherosclerotic endothelial cells paving luminal surface of blood vessels has been described in many diseases. It has been reported that natural polyunsaturated fatty acids such as docosahexaenoic acid exert therapeutic effects in atherosclerotic condition. Human umbilical vein endothelial cells were treated with 1mM palmitic acid for 48 hours and exposed to 40μM docosahexaenoic acid for the next 24 hours. Real-time polymerase chain reaction analysis was used to measure the expression of PTX3, iNOS, and eNOS...
April 13, 2018: Cell Biochemistry and Function
Pengcheng Yan, Desheng Jiang, Yuhui Tian, Li Xu, Junchao Qian, Henan Li, Jiexiang Xia, Huaming Li
As a broad-spectrum antibiotic, tetracycline (TC) is widely used in agricultural purposes and human therapy. More attention is paid to TC as a serious threat to human health, including the fast spreading of antibiotic resistance gene and the serious toxicity to aquatic organisms. Therefore, the timely and accurate determination of TC residues is an urgent task to protect the safety of human. Herein, an effective and facile photoelectrochemical sensor platform based on carbon nitride/bismuth oxyhalide (CN/BiOBr) composites can be constructed for monitoring TC...
March 24, 2018: Biosensors & Bioelectronics
Matthew R Majewski, Robert I Woodward, Jean-Yves Carreé, Samuel Poulain, Marcel Poulain, Stuart D Jackson
Optical emission from rare-earth-doped fluoride fibers has thus far been limited to less than 4 μm. We extend emission beyond this limit by employing an indium fluoride (InF3 ) glass fiber as the host, which exhibits an increased infrared transparency over commonly used zirconium fluoride (ZBLAN). Near-infrared pumping of a dysprosium-doped InF3 fiber results in broad emission centered around 4.3 μm, representing the longest emission yet achieved from a fluoride fiber. The first laser emission in an InF3 fiber is also demonstrated from the 3 μm dysprosium transition...
April 15, 2018: Optics Letters
Fenghua Zhang, Zheng Shi, Xumin Gao, Chuan Qin, Shuai Zhang, Yan Jiang, Fan Wu, Yongjin Wang
An on-chip multicomponent system is implemented on a III-nitride-on-silicon platform by integrating a transmitter, InGaN waveguide, InGaN directional coupler, and receivers onto a single chip. The transmitter and the receiver share an identical InGaN/GaN multiple-quantum-well (MQW) diode structure and are produced by using the same wafer-level process flow. The receiver sensitively responds to the short-wavelength half of the emission spectrum of the transmitter, thus realizing the multicomponent system with the capability for inplane light communication...
April 15, 2018: Optics Letters
Arnaldo Leal-Junior, Anselmo Frizera, Maria José Pontes, Paulo Antunes, Nélia Alberto, Maria Fátima Domingues, Heeyoung Lee, Ryo Ishikawa, Yosuke Mizuno, Kentaro Nakamura, Paulo André, Carlos Marques
This Letter presents, for the first time, to the best of our knowledge, the dynamic mechanical analysis of a polymer optical fiber (POF) that was previously damaged by the catastrophic fuse effect. The variation of the fiber Young's modulus was evaluated with respect to the increase of temperature, humidity, and frequency of strain cycles. The obtained data for the fused POF are compared with the ones for the same POF without the fuse effect. The results show the feasibility of the fused POF for sensor applications, such as strain and acceleration measurement, since it presents temperature sensitivity almost two times lower in temperatures between 26°C and 90°C and Young's modulus 2...
April 15, 2018: Optics Letters
Lin Guo, Magnus Rueping
The utilization of carboxylic acid esters as electrophiles in metal-catalyzed cross-coupling reactions is increasingly popular, as environmentally friendly and readily available ester derivatives can be powerful alternatives to the commonly used organohalides. However, key challenges associated with the use of these chemicals remain to be addressed, including the stability of ester substrates and the high energy barrier associated with their oxidative addition to low-valent metal species. Due to recent developments in nickel catalysis that make it easier to perform oxidative additions, chemists have become interested in applying less reactive electrophiles as coupling counterparts in nickel-catalyzed transformations...
April 13, 2018: Accounts of Chemical Research
Sergey Lepeshov, Mingsong Wang, Alex Krasnok, Oleg Kotov, Tianyi Zhang, He Liu, Taizhi Jiang, Brian A Korgel, Mauricio Terrones, Yuebing Zheng, Andrea Alu
Two-dimensional semiconducting transition metal dichalcogenides (TMDCs) are extremely attractive materials for optoelectronic applications in the visible and near-IR range. Coupling these materials to optical nanocavities enables advanced quantum optics and nanophotonic devices. Here, we address the issue of resonance coupling in hybrid exciton-polariton structures based on single Si nanoparticles (NPs) coupled to monolayer (1L) WS2. We predict strong coupling regime with a Rabi splitting energy exceeding 110 meV for a Si NPs covered by 1L-WS2 at the magnetic optical Mie resonance due to the symmetry of the mode...
April 13, 2018: ACS Applied Materials & Interfaces
Thomas Krieg, Joana Madjarov, Luis F M Rosa, Franziska Enzmann, Falk Harnisch, Dirk Holtmann, Korneel Rabaey
From the first electromicrobial experiment to a sophisticated microbial electrochemical process - it all takes place in a reactor. Whereas the reactor design and materials used strongly influence the obtained results, there are no common platforms for MES reactors. This is a critical convention gap, as cross-comparison and benchmarking among MES as well as MES vs. conventional biotechnological processes is needed. Only knowledge driven engineering of MES reactors will pave the way to application and commercialization...
April 13, 2018: Advances in Biochemical Engineering/biotechnology
Liangliang Gao, Yi Jin, Xiaofang Liu, Ming Xu, Xiaokang Lai, Jianglan Shui
High volumetric energy and power densities are crucial for Li-ion batteries, which are however hindered by the loose structure and/or insufficient conductivity of conventional electrode laminates. Herein, an efficiently conductive framework of graphene nanoribbons (GNRs) and graphene (G) is rationally constructed to wrap LiFePO4 (LFP) into a binder-free dense electrode by a coupling technique of spray deposition and vacuum filtration. The spray ensures a uniform mixing of LFP, G and GNRs, meanwhile the vacuum filtration leads to a dense packing of the mixture...
April 13, 2018: Nanoscale
Sven Grätz, Doreen Beyer, Valeriya Tkachova, Sarah Hellmann, Reinhard Berger, Xinliang Feng, Lars Borchardt
Herein, we report on the mechanochemical Scholl reaction of dendritic oligophenylene precursors to produce benchmark nanographenes such as hexa-peri-hexabenzocoronene (HBC), triangular shaped C60 and expanded C222 under solvent-free conditions. The solvent-free approach overcomes the bottleneck of solubility limitation in this well-known and powerful reaction. The mechanochemical approach allows tracking the reaction process by in situ pressure measurements. The quality of produced nanographenes has been confirmed by MALDI-TOF mass spectrometry and UV-Vis absorption spectroscopy...
April 13, 2018: Chemical Communications: Chem Comm
N Lozovaya, S Eftekhari, R Cloarec, L A Gouty-Colomer, A Dufour, B Riffault, M Billon-Grand, A Pons-Bennaceur, N Oumar, N Burnashev, Y Ben-Ari, C Hammond
We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents and an inhibitory pause response. Dopamine deprivation increases CGINs ongoing activity and abolishes GABAergic inhibition including the cortico-striatal pause because of high [Cl- ]i levels. Dopamine deprivation also dramatically increases CGINs dendritic arbors and monosynaptic interconnections probability, suggesting the formation of a dense CGINs network...
April 12, 2018: Nature Communications
C Lakshmi, K Thenmozhi, John Bosco Balaguru Rayappan, Rengarajan Amirtharajan
Digital Imaging and Communications in Medicine (DICOM) is one among the significant formats used worldwide for the representation of medical images. Undoubtedly, medical-image security plays a crucial role in telemedicine applications. Merging encryption and watermarking in medical-image protection paves the way for enhancing the authentication and safer transmission over open channels. In this context, the present work on DICOM image encryption has employed a fuzzy chaotic map for encryption and the Discrete Wavelet Transform (DWT) for watermarking...
June 2018: Computer Methods and Programs in Biomedicine
Charlie Demene, Jérôme Mairesse, Jérôme Baranger, Mickael Tanter, Olivier Baud
The emergence of functional neuroimaging has dramatically accelerated our understanding of the human mind. The advent of functional Magnetic Resonance Imaging paved the way for the next decades' major discoveries in neuroscience and today remains the "gold standard" for deep brain imaging. Recent improvements in imaging technology have been somewhat limited to incremental innovations of mature techniques instead of breakthroughs. Recently, the use of ultrasonic plane waves transmitted at ultrafast frame rates was shown to highly increase Doppler ultrasound sensitivity to blood flows in small vessels in rodents...
April 9, 2018: NeuroImage
Lei Xu, Yiran Shao, Chengkang Chang, Yingchun Zhu
Tumor hypoxia is known to result in radiotherapy resistance and traditional radiotherapy using super-hard X-ray irradiation can cause considerable damage to normal tissue. Therefore, formamide peroxide (FPO) with high reactive oxygen content was employed to enhance the oxygen concentration in tumor cells and increase the radio-sensitivity of low-energy soft-X-ray. To improve stability of FPO, FPO is encapsulated into polyacrylic acid (PAA)-coated hollow mesoporous silica nanoparticles (FPO@HMSNs-PAA). On account of the pH-responsiveness of PAA, FPO@HMSNs-PAA will release more FPO in simulated acidic tumor microenvironment (pH 6...
April 12, 2018: Materials
Tiziana Vaisitti, Francesca Arruga, Silvia Deaglio
Targeting adenosine triphosphate (ATP) metabolism and adenosinergic signaling in cancer is gaining momentum, as increasing evidence is showing their relevance in tumor immunology and biology. Chronic lymphocytic leukemia (CLL) results from the expansion of a population of mature B cells that progressively occupies the bone marrow (BM), the blood, and peripheral lymphoid organs. Notwithstanding significant progress in the treatment of these patients, the cure remains an unmet clinical need, suggesting that novel drugs or drug combinations are needed...
April 12, 2018: International Journal of Molecular Sciences
Cheriyacheruvakkara Owais, Anto James, Chris John, Rama Dhali, Rotti Srinivasamurthy Swathi
Research on the permeation of various species through one-atom-thick nanoporous carbon membranes has gained an unprecedented importance in the last decade, thanks to the development of numerous theoretical design strategies for a plethora of applications ranging from gas separation, water desalination, isotope separation, and chiral separation, to DNA sequencing. Although some of the recent experiments have demonstrated successful performance of such carbon membranes in sieving, many of the suggested applications are yet to be realized in experiments...
April 12, 2018: Journal of Physical Chemistry. B
Yu Huang, Fuwei Zhuge, Junxian Hou, Liang Lv, Peng Luo, Nan Zhou, Lin Gan, Tianyou Zhai
As a direct bandgap transition metal dichalcogenide, atomic thin MoS2 has attracted extensive attentions in photodetection, whereas the hitherto unsolved persistent photoconductance (PPC) from the ungoverned charge trapping in devices has severely hindered their employments. Herein, we demonstrate the realization of ultrafast photoresponse dynamics in monolayer MoS2 by exploiting a charge transfer interface based on surface assembled zinc phthalocyanine (ZnPc) molecules. The formed MoS2/ZnPc Van der Waals interface is found to favorably suppress PPC phenomenon in MoS2 by instantly separating photogenerated holes to the ZnPc molecules, away from the traps in MoS2 and the dielectric interface...
April 12, 2018: ACS Nano
Jiuyang Liu, Shuya Zhang, Mingqing Liu, Yaqian Liu, Gilbert Nshogoza, Jia Gao, Rongsheng Ma, Yang Yang, Jihui Wu, Jiahai Zhang, Fudong Li, Ke Ruan
As a reader of di-methylated arginine on various proteins, such as histone, RNA polymerase II, PIWI and Fragile X mental retardation protein, the Tudor domain of Tudor domain-containing protein 3 (TDRD3) mediates transcriptional activation in nucleus and formation of stress granules in the cytoplasm. Despite the TDRD3 implication in cancer cell proliferation and invasion, warheads to block the di-methylated arginine recognition pocket of the TDRD3 Tudor domain have not yet been uncovered. Here we identified 14 small molecule hits against the TDRD3 Tudor domain through NMR fragment-based screening...
April 12, 2018: FEBS Journal
Duc-Hanh Nguyen, Émilien Azéma, Philippe Sornay, Farhang Radjaï
We investigate sheared granular materials composed of crushable particles by means of contact dynamics simulations and the bonded-cell model for particle breakage. Each particle is paved by irregular cells interacting via cohesive forces. In each simulation, the ratio of the internal cohesion of particles to the confining pressure, the relative cohesion, is kept constant and the packing is subjected to biaxial shearing. The particles can break into two or more fragments when the internal cohesive forces are overcome by the action of compressive force chains between particles...
April 11, 2018: European Physical Journal. E, Soft Matter
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