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https://www.readbyqxmd.com/read/28719951/neuronal-apoptosis-pathological-basis-of-behavioral-dysfunctions-induced-by-angiostrongylus-cantonensis-in-rodents-model
#1
Shiqi Luo, Lisi OuYang, Jie Wei, Feng Wu, Zhongdao Wu, Wanlong Lei, Dongjuan Yuan
Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, the pathological basis of these manifestations is incompletely elucidated. In this study, the behavioral test, histological and immunohistochemical techniques, and analysis of apoptotic gene expression, especially caspase-3, were conducted...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719144/maximizing-the-stability-of-metabolic-engineering-derived-whole-cell-biocatalysts
#2
REVIEW
Marvin Kadisch, Christian Willrodt, Michael Hillen, Bruno Bühler, Andreas Schmid
A systematic and powerful knowledge-based framework exists for improving the activity and stability of chemical catalysts and for empowering the commercialization of respective processes. In contrast, corresponding biotechnological processes are still scarce and characterized by case-by-case development strategies. A systematic understanding of parameters affecting biocatalyst efficiency, that is, biocatalyst activity and stability, is essential for a rational generation of improved biocatalysts. Today, systematic approaches only exist for increasing the activity of whole-cell biocatalysts...
July 18, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28719071/mesoporous-silica-thin-membranes-with-large-vertical-mesochannels-for-nanosize-based-separation
#3
Yupu Liu, Dengke Shen, Gang Chen, Ahmed A Elzatahry, Manas Pal, Hongwei Zhu, Longlong Wu, Jianjian Lin, Daifallah Al-Dahyan, Wei Li, Dongyuan Zhao
Membrane separation technologies are of great interest in industrial processes such as water purification, gas separation, and materials synthesis. However, commercial filtration membranes have broad pore size distributions, leading to poor size cutoff properties. In this work, mesoporous silica thin membranes with uniform and large vertical mesochannels are synthesized via a simple biphase stratification growth method, which possess an intact structure over centimeter size, ultrathin thickness (≤50 nm), high surface areas (up to 1420 m(2) g(-1) ), and tunable pore sizes from ≈2...
July 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28719061/tailored-engineering-of-an-unusual-c4h9nh3-2-ch3nh3-2pb3br10-two-dimensional-multilayered-perovskite-ferroelectric-for-high-performance-photodetectors
#4
Junhua Luo, Lina Li, Zhihua Sun, Peng Wang, Weida Hu, Sasa Wang, Chengmin Ji, Maochun Hong
Two-dimensional (2D) layered hybrid perovskites have shown great potentials in optoelectronics. However, although great efforts have been made, 2D hybrid perovskite ferroelectrics remain rare. Here, we constructed the first ferroelectric with 2D multilayered perovskite framework, (C4H9NH3)2(CH3NH3)2Pb3Br10 (1), by tailored alloying mixed-organic-cations into the prototype of CH3NH3PbBr3. For the first time, concrete ferroelectricity was created by molecular reorientation and synergic ordering of organic cations, which is unprecedented for the known 2D hybrid perovskites...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28719040/discovering-long-term-potentiation-ltp-recollections-and-reflections-on-what-came-after
#5
REVIEW
Terje Lømo
Chance events led me to a lifelong career in scientific research. They paved the way for being the first to see long-term potentiation of synaptic efficiency (LTP) in Per Andersen's lab in Oslo in 1966. Here I describe my way to this discovery and the experiments with Tim Bliss in 1968-1969 that led to Bliss and Lømo, 1973. Surprisingly, we later failed to reproduce these results. I discuss possible reasons for this failure, which made us both leave LTP research, in my case for good, in Tim's case for several years...
July 18, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28718988/hydrogels-with-dual-thermoresponsive-mechanical-performance
#6
Hui Guo, Cécile Mussault, Alba Marcellan, Dominique Hourdet, Nicolas Sanson
Dual thermoresponsive chemical hydrogels, combining poly(N-isopropylacrylamide) side-chains within a poly(N-acryloylglycinamide) network, are designed following a simple and versatile procedure. These hydrogels exhibit two phase transitions both at low (upper critical solution temperature) and high (lower critical solution temperature) temperatures, thereby modifying their swelling, rheological, and mechanical properties. These novel thermo-schizophrenic hydrogels pave the way for the development of thermotoughening wet materials in a broad range of temperatures...
July 18, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28718822/a-bacterial-toxin-with-analgesic-properties-hyperpolarization-of-drg-neurons-by-mycolactone
#7
Ok-Ryul Song, Han-Byul Kim, Samuel Jouny, Isabelle Ricard, Alexandre Vandeputte, Nathalie Deboosere, Estelle Marion, Christophe J Queval, Pierre Lesport, Emmanuel Bourinet, Daniel Henrion, Seog Bae Oh, Guillaume Lebon, Guillaume Sandoz, Edouard Yeramian, Laurent Marsollier, Priscille Brodin
Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. We demonstrated that the analgesic capability of mycolactone was not attributable to nerve damage, but instead resulted from the triggering of a cellular pathway targeting AT₂ receptors (angiotensin II type 2 receptors; AT₂R), and leading to potassium-dependent hyperpolarization...
July 18, 2017: Toxins
https://www.readbyqxmd.com/read/28718442/wnt-planar-cell-polarity-signaling-new-opportunities-for-cancer-treatment
#8
REVIEW
Avais M Daulat, Jean-Paul Borg
Cancer cells are addicted to a large spectrum of extracellular cues implicated in initiation, stem cell renewal, tumor growth, dissemination in the body, and resistance to treatment. Wingless/Int-1 (Wnt) ligands and their associated signaling cascades contribute to most of these processes, paving the way for opportunities in therapeutic development. The developmental Wnt/planar cell polarity (PCP) pathway is the most recently described branch of Wnt signaling strongly implicated in cancer development at early and late stages...
February 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28718407/cell-and-tissue-biology-paves-a-path-to-breast-cancer-prevention
#9
Michael E Todhunter, Mark A LaBarge
We hypothesize that breast cancer susceptibility stems from interactions between difficult-to-modify cultural and dietary habits and aging processes that are modifiable. We propose a pathway to prevention that uses human organotypic systems that recapitulate hallmarks of aging in order to better understand and to modulate the biological consequences of aging in breast.
May 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28717940/alopecia-areata-a-comprehensive-review-of-pathogenesis-and-management
#10
REVIEW
Ralph M Trüeb, Maria Fernanda Reis Gavazzoni Dias
Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. The current understanding is that the condition represents an organ-specific autoimmune disease of the hair follicle with a genetic background. Genome-wide association studies provide evidence for the involvement of both innate and acquired immunity in the pathogenesis, and mechanistic studies in mouse models of alopecia areata have specifically implicated an IFN-γ-driven immune response, including IFNγ, IFNγ-induced chemokines and cytotoxic CD8 T cells as the main drivers of disease pathogenesis...
July 17, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28717845/proteomics-in-inflammatory-bowel-disease-approach-using-animal-models
#11
REVIEW
Fadi H Mourad, Yunki Yau, Valerie C Wasinger, Rupert W Leong
Recently, proteomics studies have provided important information on the role of proteins in health and disease. In the domain of inflammatory bowel disease, proteomics has shed important light on the pathogenesis and pathophysiology of inflammation and has contributed to the discovery of some putative clinical biomarkers of disease activity. By being able to obtain a large number of specimens from multiple sites and control for confounding environmental, genetic, and metabolic factors, proteomics studies using animal models of colitis offered an alternative approach to human studies...
July 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28717316/induced-pluripotent-stem-cell-a-headway-in-reprogramming-with-promising-approach-in-regenerative-biology
#12
REVIEW
N Rawat, M K Singh
Since the embryonic stem cells have knocked the doorsteps, they have proved themselves in the field of science, research, and medicines, but the hovered restrictions confine their application in human welfare. Alternate approaches used to reprogram the cells to the pluripotent state were not up to par, but the innovation of induced pluripotent stem cells (iPSCs) paved a new hope for the researchers. Soon after the discovery, iPSCs technology is undergoing renaissance day by day, i.e., from the use of genetic material to recombinant proteins and now only chemicals are employed to convert somatic cells to iPSCs...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28717162/ultra-low-threshold-polariton-lasing-at-room-temperature-in-a-gan-membrane-microcavity-with-a-zero-dimensional-trap
#13
R Jayaprakash, F G Kalaitzakis, G Christmann, K Tsagaraki, M Hocevar, B Gayral, E Monroy, N T Pelekanos
Polariton lasers are coherent light sources based on the condensation of exciton-polaritons in semiconductor microcavities, which occurs either in the kinetic or thermodynamic (Bose-Einstein) regime. Besides their fundamental interest, polariton lasers have the potential of extremely low operating thresholds. Here, we demonstrate ultra-low threshold polariton lasing at room temperature, using an all-dielectric, GaN membrane-based microcavity, with a spontaneously-formed zero-dimensional trap. The microcavity is fabricated using an innovative method, which involves photo-electrochemical etching of an InGaN sacrificial layer and allows for the incorporation of optimally-grown GaN active quantum wells inside a cavity with atomically-smooth surfaces...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716408/molecular-and-biochemical-characterization-of-a-vigna-mungo-map-kinase-associated-with-mungbean-yellow-mosaic-india-virus-infection-and-deciphering-its-role-in-restricting-the-virus-multiplication
#14
Anju Patel, Nrisingha Dey, Shubho Chaudhuri, Amita Pal
Yellow Mosaic Disease caused by the begomovirus Mungbean Yellow Mosaic India Virus (MYMIV) severely affects many economically important legumes. Recent investigations in Vigna mungo - MYMIV incompatible interaction identified a MAPK homolog in the defense signaling pathway. An important branch of immunity involves phosphorylation by evolutionary conserved Mitogen-activated protein kinases (MAPK) that transduce signals of pathogen invasion to downstream molecules leading to diverse immune responses. However, most of the knowledge of MAPKs is derived from model crops, and functions of these versatile kinases are little explored in legumes...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28716353/assessment-of-progress-towards-universal-health-coverage-for-people-with-disabilities-in-afghanistan-a-multilevel-analysis-of-repeated-cross-sectional-surveys
#15
Jean-Francois Trani, Praveen Kumar, Ellis Ballard, Tarani Chandola
BACKGROUND: Since 2002, Afghanistan has made much effort to achieve universal health coverage. According to the UN Sustainable Development Goal 3, target eight, the provision of quality care to all must include usually underserved groups, including people with disabilities. We investigated whether a decade of international investment in the Afghan health system has brought quality health care to this group. METHODS: We used data from two representative household surveys, one done in 2005 and one in 2013, in 13 provinces of Afghanistan, that included questions about activity limitations and functioning difficulties, socioeconomic factors, perceived availability of health care, and experience with coverage of health-care needs...
August 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28716051/mir-380-5p-mediated-repression-of-tep1-and-tspyl5-interferes-with-telomerase-activity-and-favours-the-emergence-of-an-alt-like-phenotype-in-diffuse-malignant-peritoneal-mesothelioma-cells
#16
Graziella Cimino-Reale, Paolo Gandellini, Francesca Santambrogio, Marta Recagni, Nadia Zaffaroni, Marco Folini
BACKGROUND: Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease...
July 17, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28715126/an-engineered-photoswitchable-mammalian-pyruvate-kinase
#17
Stefanie Gehrig, Jamie A Macpherson, Paul C Driscoll, Alastair Symon, Stephen R Martin, James I MacRae, Jens Kleinjung, Franca Fraternali, Dimitrios Anastasiou
Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms control enzyme function at significantly shorter time-scales compared to the long-term effects of metabolic reprogramming on cell proliferation. It remains unclear if and how the speed and reversibility afforded by rapid allosteric control of metabolic enzymes is important for cell proliferation. Tools that allow specific, dynamic modulation of enzymatic activities in mammalian cells would help address this question...
July 17, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28715025/compressed-few-layer-black-phosphorus-nanosheets-from-semiconducting-to-metallic-transition-with-the-highest-symmetry
#18
Guanjun Xiao, Ye Cao, Guangyu Qi, Lingrui Wang, Qingxin Zeng, Chuang Liu, Zhiwei Ma, Kai Wang, Xinyi Yang, Yongming Sui, Weitao Zheng, Bo Zou
The high-pressure response of few-layer black phosphorus (BP) nanosheets remains elusive, despite the special interest in it particularly after the achievement of an exotic few-layer BP based field effect transistor. Here, we identified a pressure-induced reversible phase transition on few-layer BP nanosheets by performing in situ ADXRD and Raman spectroscopy with the assistance of DAC apparatus. The few-layer BP nanosheets transformed from orthorhombic semiconductors to simple cubic metal with increasing pressure, which is well interpreted using the pressure-induced inverse Peierls distortion...
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28715012/the-properties-of-residual-water-molecules-in-ionic-liquids-a-comparison-between-direct-and-inverse-kirkwood-buff-approaches
#19
Takeshi Kobayashi, Joshua E S J Reid, Seishi Shimizu, Maria Fyta, Jens Smiatek
We study the properties of residual water molecules at different mole fractions in dialkylimidazolium based ionic liquids (ILs), namely 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM/BF4) and 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM/BF4) by means of atomistic molecular dynamics (MD) simulations. The corresponding Kirkwood-Buff (KB) integrals for the water-ion and ion-ion correlation behavior are calculated by a direct evaluation of the radial distribution functions. The outcomes are compared to the corresponding KB integrals derived by an inverse approach based on experimental data...
July 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28714985/electrical-pumping-and-tuning-of-exciton-polaritons-in-carbon-nanotube-microcavities
#20
Arko Graf, Martin Held, Yuriy Zakharko, Laura Tropf, Malte C Gather, Jana Zaumseil
Exciton-polaritons are hybrid light-matter particles that form upon strong coupling of an excitonic transition to a cavity mode. As bosons, polaritons can form condensates with coherent laser-like emission. For organic materials, optically pumped condensation was achieved at room temperature but electrically pumped condensation remains elusive due to insufficient polariton densities. Here we combine the outstanding optical and electronic properties of purified, solution-processed semiconducting (6,5) single-walled carbon nanotubes (SWCNTs) in a microcavity-integrated light-emitting field-effect transistor to realize efficient electrical pumping of exciton-polaritons at room temperature with high current densities (>10 kA cm(-2)) and tunability in the near-infrared (1,060 nm to 1,530 nm)...
July 17, 2017: Nature Materials
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