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https://www.readbyqxmd.com/read/29453414/chemisorption-of-polysulfides-through-redox-reactions-with-organic-molecules-for-lithium-sulfur-batteries
#1
Ge Li, Xiaolei Wang, Min Ho Seo, Matthew Li, Lu Ma, Yifei Yuan, Tianpin Wu, Aiping Yu, Shun Wang, Jun Lu, Zhongwei Chen
Lithium-sulfur battery possesses high energy density but suffers from severe capacity fading due to the dissolution of lithium polysulfides. Novel design and mechanisms to encapsulate lithium polysulfides are greatly desired by high-performance lithium-sulfur batteries towards practical applications. Herein, we report a strategy of utilizing anthraquinone, a natural abundant organic molecule, to suppress dissolution and diffusion of polysulfides species through redox reactions during cycling. The keto groups of anthraquinone play a critical role in forming strong Lewis acid-based chemical bonding...
February 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29453411/the-impact-of-a-helminth-modified-microbiome-on-host-immunity
#2
REVIEW
Tara P Brosschot, Lisa A Reynolds
Intestinal helminths have well-characterized modulatory effects on mammalian immune pathways. Ongoing helminth infection has been associated with both the suppression of allergies and an altered susceptibility to microbial infections. Enteric helminths share a niche with the intestinal microbiota, and the presence of helminths alters the microbiota composition and the metabolic signature of the host. Recent studies have demonstrated that the helminth-modified intestinal microbiome has the capacity to modify host immune responses even in the absence of live helminth infection...
February 16, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29452944/iron-engineered-mesoporous-silica-nanocatalyst-with-biodegradable-and-catalytic-framework-for-tumor-specific-therapy
#3
Liying Wang, Minfeng Huo, Yu Chen, Jianlin Shi
Inorganic mesoporous silica-based nanovehicles are highly promising for drug delivery but still suffer from the disadvantages of lacking functionality and poor biodegradability on account of the inert silica framework. Moreover, conventional cancer therapeutics typically employ toxic anticancer drugs or invasive external irradiations, which will inevitably give rise to severe adverse effects and diminished therapeutic outcome. In this work, we report on the iron engineered framework of mesoporous silica nanoparticles (MSNs) to fabricate a nanocatalyst with biodegradable and catalytic framework via a "dissolution-regeneration" strategy (designated as rFeO x -HMSN)...
February 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29452662/pathogenesis-of-follicular-lymphoma
#4
REVIEW
Tracy Lackraj, Rashmi Goswami, Robert Kridel
Follicular lymphoma (FL) is presented as a germinal centre B cell lymphoma that is characterized by an indolent clinical course, but remains - paradoxically - largely incurable to date. The last years have seen significant progress in our understanding of FL lymphomagenesis, which is a multi-step process beginning in the bone marrow with the hallmark t(14;18)(q32;q21) translocation. The pathobiology of FL is complex and combines broad somatic changes at the level of both the genome and the epigenome, the latter evidenced by highly recurrent mutations in chromatin-modifying genes such as KMT2D and CREBBP...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29452623/currently-available-radiopharmaceuticals-for-imaging-infection-and-the-holy-grail
#5
REVIEW
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29452238/human-adipose-tissue-derived-stromal-cells-in-combination-with-exogenous-stimuli-facilitate-three-dimensional-network-formation-of-human-endothelial-cells-derived-from-various-sources
#6
Dominique Manikowski, Birgit Andrée, Esther Samper, Clémence Saint-Marc, Ruth Olmer, Peter Vogt, Sarah Strauß, Axel Haverich, Andres Hilfiker
In natural tissues, the nutrition of cells and removal of waste products is facilitated by a dense capillary network which is generated during development. This perfusion system is also indispensable for tissue formation in vitro. Nutrition depending solely on diffusion is not sufficient to generate tissues of clinically relevant dimensions, which is a core aim in tissue engineering research. In this study, the establishment of a vascular network was investigated in a self-assembling approach employing endothelial and mural cells...
February 13, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29451386/optically-switchable-photocatalysis-in-ultrathin-black-phosphorus-nanosheets
#7
Hui Wang, Shenlong Jiang, Wei Shao, Xiaodong Zhang, Shichuan Chen, Xianshun Sun, Qun Zhang, Yi Luo, Yi Xie
Recently low-dimensional materials hold great potential in the field of photocatalysis, whereas the concomitantly promoted many-body effects have long been ignored. Such Coulomb interaction-mediated effects would lead to some intriguing, nontrivial band structures, thus promising versatile photocatalytic performances and optimized strategies. Here, we demonstrate that ultrathin black phosphorus (BP) nanosheets exhibit an exotic, excitation-energy-dependent, optical switching effect in photocatalytic reactive oxygen species (ROS) generation...
February 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29450658/modified-allergens-for-immunotherapy
#8
REVIEW
Pattraporn Satitsuksanoa, Anna Głobińska, Kirstin Jansen, Willem van de Veen, Mübeccel Akdis
PURPOSE OF REVIEW: During the past few decades, modified allergens have been developed for use in allergen-specific immunotherapy (AIT) with the aim to improve efficacy and reduce adverse effects. This review aims to provide an overview of the different types of modified allergens, their mechanism of action and their potential for improving AIT. RECENT FINDINGS: In-depth research in the field of allergen modifications as well as the advance of recombinant DNA technology have paved the way for improved diagnosis and research on human allergic diseases...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29449763/the-history-of-ifompt-paving-the-way-to-global-leadership-in-ompt-excellence
#9
EDITORIAL
M Elaine Lonnemann, Ken A Olson, Jean-Michel Brismée
No abstract text is available yet for this article.
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29449596/heparan-sulfates-facilitate-harmless-amyloidogenic-fibril-formation-interacting-with-elastin-like-peptides
#10
Federica Boraldi, Pasquale Moscarelli, Brigida Bochicchio, Antonietta Pepe, Anna M Salvi, Daniela Quaglino
Heparan sulfates (HSs) modulate tissue elasticity in physiopathological conditions by interacting with various matrix constituents as tropoelastin and elastin-derived peptides. HSs bind also to protein moieties accelerating amyloid formation and influencing cytotoxic properties of insoluble fibrils. Interestingly, amyloidogenic polypeptides, despite their supposed pathogenic role, have been recently explored as promising bio-nanomaterials due to their unique and interesting properties. Therefore, we investigated the interactions of HSs, obtained from different sources and exhibiting various degree of sulfation, with synthetic amyloidogenic elastin-like peptides (ELPs), also looking at the effects of these interactions on cell viability and cell behavior using in vitro cultured fibroblasts, as a prototype of mesenchymal cells known to modulate the soft connective tissue environment...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449578/probing-conformal-invariant-of-non-unitary-two-dimensional-systems-by-central-spin-decoherence
#11
Bo-Bo Wei
Universality classes of non-unitary critical theories in two-dimensions are characterized by the central charge. However, experimental determination of the central charge of a non-unitary critical theory has not been done before because of the intrinsic difficulty that complex parameters usually occur in non-unitary theory, which is not physical. Here we propose to extract the effective central charge of the non-unitary critical point of a two-dimensional lattice model from the quantum coherence measurement of a probe spin which is coupled to the lattice model...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449570/in-situ-visualization-of-sound-induced-otolith-motion-using-hard-x-ray-phase-contrast-imaging
#12
Tanja Schulz-Mirbach, Margie Olbinado, Alexander Rack, Alberto Mittone, Alberto Bravin, Roland R Melzer, Friedrich Ladich, Martin Heß
Regarding the basics of ear structure-function relationships in fish, the actual motion of the solid otolith relative to the underlying sensory epithelium has rarely been investigated. Otolith motion has been characterized based on a few experimental studies and on approaches using mathematical modeling, which have yielded partially conflicting results. Those studies either predicted a simple back-and-forth motion of the otolith or a shape-dependent, more complex motion. Our study was designed to develop and test a new set-up to generate experimental data on fish otolith motion in-situ...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29449564/aggregation-fragmentation-and-individual-dynamics-of-active-clusters
#13
F Ginot, I Theurkauff, F Detcheverry, C Ybert, C Cottin-Bizonne
A remarkable feature of active matter is the propensity to self-organize. One striking instance of this ability to generate spatial structures is the cluster phase, where clusters broadly distributed in size constantly move and evolve through particle exchange, breaking or merging. Here we propose an exhaustive description of the cluster dynamics in apolar active matter. Exploiting large statistics gathered on thousands of Janus colloids, we measure the aggregation and fragmentation rates and rationalize the resulting cluster size distribution and fluctuations...
February 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29449372/ligand-mediated-protein-degradation-reveals-functional-conservation-among-sequence-variants-of-the-cul4-type-e3-ligase-substrate-receptor-cereblon
#14
Afua A Akuffo, Aileen Y Alontaga, Rainer Metcalf, Matthew S Beatty, Andreas Becker, Jessica M McDaniel, Rebecca S Hesterberg, William E Goodheart, Steven Gunawan, Muhammad Ayaz, Yan Yang, Md Rezaul Karim, Morgan E Orobello, Kenyon Daniel, Wayne Guida, Jeffrey A Yoder, Anjali M Rajadhyaksha, Ernst Schonbrunn, Harshani R Lawrence, Nicholas J Lawrence, Pearlie K Epling-Burnette
Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteasomal destruction by engaging the DDB1-CUL4A-Roc1-RBX1 E3-ubiquitin ligase in human cells but not in mouse cells suggesting that sequence variations in CRBN may cause its inactivation. Therapeutically, CRBN engagers have the potential for broad applications in cancer and immune therapy by specifically reducing protein expression through targeted ubiquitin-mediated degradation. To examine the effects of defined sequence changes on CRBNs activity, we performed a comprehensive study using complementary theoretical, biophysical, and biological assays aimed at understanding CRBNs non-primate sequence variations...
February 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29448911/investigation-of-the-selectivity-of-one-type-of-small-molecule-inhibitor-for-three-na-v-channel-isoforms-based-on-the-method-of-computer-simulation
#15
Fan Zhao, Wei Jin, Lin Ma, Jian-Ye Zhang, Jin-Long Wang, Jing-Hai Zhang, Yong-Bo Song
Voltage-gated sodium (Na v ) channels play a pivotal role for the changes in membrane potential and belong to large membrane proteins that compose four voltage sensor domains (VSD1-4). In this study we describe the binding mode and selectivity of one of the aryl sulfonamide sodium channel inhibitors, PF-04856264, for the VSD4s in Na v 1.4, Na v 1.5 and Na v 1.7, respectively, through molecular dynamics simulation and enhanced post-dynamics analyses. Our results show that there are three binding site regions (BSR1-3) in the combination of the ligand and receptors, of which BSR1 and BSR3 contribute to the selectivity and affinity of the ligand to the receptor...
February 15, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29448723/preparation-of-nanoscale-zinc-oxide-laponite-composites-by-polyvinyl-alcohol-polymerization-and-usability-for-removal-of-trichloroethylene-in-water
#16
Jong Kyu Kim, Hosang Ahn, Jong-Ho Kim, Yang-Jin Ban, Keugtae Kim, Jin Chul Joo
Innovative nanoscale ZnO-laponite-polyvinyl alcohol composites (NZLPc) were developed as a valid alternative to nanoscale photocatalysts for mineralization of chlorinated hydrocarbons without difficulties in recovery of nanoscale photocatalyst particles. NZLPc were synthesized by mixing nanoscale ZnO particles with laponite in PVA solution, and by crosslinking PVA solution in the presence of boric acid (≥1.6 M). Different mixing ratios of the raw materials were investigated to develop the stable NZLPc, and X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy characterizations were performed...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447671/label-free-and-sensitive-microrna-detection-based-on-a-target-recycling-amplification-integrated-superlong-poly-thymine-hosted-copper-nanoparticle-strategy
#17
Fengzhou Xu, Lan Luo, Hui Shi, Xiaoxiao He, Yanli Lei, Jinlu Tang, Dinggeng He, Zhenzhen Qiao, Kemin Wang
Poly(thymine)-hosted copper nanoparticles (poly T-CuNPs) have emerged as a promising label-free fluorophore for bioanalysis, but its application in RNA-related studies is still rarely explored. Herein, by utilizing duplex-specific nuclease (DSN) as a convertor to integrate target recycling mechanism into terminal deoxynucleotidyl transferase (TdT)-mediated superlong poly T-CuNPs platform, a specific and sensitive method for microRNA detection has been developed. In this strategy, a 3'-phosphorylated DNA probe can hybridize with target RNA and then be cut by DSN to produce 3'-hydroxylated fragments, which can be further tailed by TdT with superlong poly T for fluorescent CuNPs synthesis...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29446423/computational-investigation-on-dna-sequencing-using-functionalized-graphene-nanopores
#18
You-Sheng Yu, Xiang Lu, Hong-Ming Ding, Yu-Qiang Ma
Fast, low-cost and reliable DNA sequencing is one of the most desirable innovations in recent years, which can pave the way for high throughput, label-free and inexpensive personalized genome sequencing techniques. Although graphene-based nanopore devices hold great promise for next-generation DNA sequencing, it is still a challenging problem to detect different DNA sequences efficiently and accurately. In the present work, the translocation of four homogeneous DNA strands (i.e., poly(A) 20 , poly(C) 20 , poly(G) 20 , and poly(T) 20 ) through the functionalized graphene nanopores is investigated by all-atom molecular dynamic simulations...
February 15, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29446214/new-developments-in-india-concerning-the-policy-of-passive-euthanasia
#19
Scaria Kanniyakonil
Euthanasia and assisted dying are illegal in India according to Sections 306 and 309 of the Indian Penal Code (IPC), and Article 21 of the Constitution of India. There have been a number of cases where the Indian High Courts and Indian Supreme Court issued differing verdicts concerning the right to life and the right to die. Nevertheless, on 7 March 2011, a paradigm shift happened as a result of the Indian Supreme Court's judgment on involuntary passive euthanasia in the case of Aruna Shanbaug. In its judgment, the Supreme Court requested the government to prepare a law on euthanasia...
February 15, 2018: Developing World Bioethics
https://www.readbyqxmd.com/read/29445956/high-performance-of-pedot-pss-n-si-solar-cells-based-on-textured-surface-with-agnws-electrodes
#20
Xiangyu Jiang, Pengbo Zhang, Juan Zhang, Jilei Wang, Gaofei Li, Xiaohong Fang, Liyou Yang, Xiaoyuan Chen
Hybrid heterojunction solar cells (HHSCs) have gained extensive research and attention due to simple device structure and low-cost technological processes. Here, HHSCs are presented based on a highly transparent conductive polymer poly(3,4ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS) directly spin-coated on an n-type crystalline silicon with microscale surface textures, which are prepared by traditional chemical etching. We have studied interface properties between PEDOT:PSS and textured n-Si by varying coating conditions...
February 14, 2018: Nanoscale Research Letters
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