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https://www.readbyqxmd.com/read/29036205/characterization-of-micrornas-of-beta-macrocarpa-and-their-responses-to-beet-necrotic-yellow-vein-virus-infection
#1
Jun-Ying Liu, Hui-Yan Fan, Ying Wang, Yong-Liang Zhang, Da-Wei Li, Jia-Lin Yu, Cheng-Gui Han
Plant microRNAs (miRNAs) are a class of non-coding RNAs that play important roles in plant development, defense, and symptom development. Here, 547 known miRNAs representing 129 miRNA families, and 282 potential novel miRNAs were identified in Beta macrocarpa using small RNA deep sequencing. A phylogenetic analysis was performed, and 8 Beta lineage-specific miRNAs were identified. Through a differential expression analysis, miRNAs associated with Beet necrotic yellow vein virus (BNYVV) infection were identified and confirmed using a microarray analysis and stem-loop RT-qPCR...
2017: PloS One
https://www.readbyqxmd.com/read/29035328/pterodontic-acid-isolated-from-laggera-pterodonta-inhibits-viral-replication-and-inflammation-induced-by-influenza-a-virus
#2
Wenda Guan, Jing Li, Qiaolian Chen, Zhihong Jiang, Rongping Zhang, Xinhua Wang, Zifeng Yang, Xiping Pan
Laggera pterodonta (DC.) Benth. is a traditional Chinese medicine. The previous study revealed that the crude extracts of this herb could inhibit influenza virus infection, but its anti-influenza components and underlying mechanism of action remain unknown. Column chromatography was performed to isolate components from the plant. Activity against influenza virus of the compound was determined by CPE inhibition assay. Neuraminidase (NA) inhibition was measured by chemiluminescence assay. The anti-virus and anti-inflammation effects were determined using dual-luciferase reporter assay, immunofluorescence, quantitative real-time PCR and luminex assay...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29033949/microarray-analysis-identifies-the-potential-role-of-long-non-coding-rna-in-regulating-neuroinflammation-during-japanese-encephalitis-virus-infection
#3
Yunchuan Li, Hao Zhang, Bibo Zhu, Usama Ashraf, Zheng Chen, Qiuping Xu, Dengyuan Zhou, Bohan Zheng, Yunfeng Song, Huanchun Chen, Jing Ye, Shengbo Cao
Japanese encephalitis virus (JEV) is the leading cause of epidemic encephalitis worldwide. JEV-induced neuroinflammation is characterized by profound neuronal cells damage accompanied by activation of glial cells. Albeit long non-coding RNAs (lncRNAs) have been emerged as important regulatory RNAs with profound effects on various biological processes, it is unknown how lncRNAs regulate JEV-induced inflammation. Here, using microarray approach, we identified 618 lncRNAs and 1,007 mRNAs differentially expressed in JEV-infected mice brain...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033947/interferon-%C3%AE-s-front-line-guardians-of-immunity-and-homeostasis-in-the-respiratory-tract
#4
REVIEW
Evangelos Andreakos, Maria Salagianni, Ioanna E Galani, Ourania Koltsida
Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute a new addition to the IFN family. They are induced upon infection and are particularly abundant at barrier surfaces, such as the respiratory and gastrointestinal tracts. Although they signal through a unique heterodimeric receptor complex comprising IFNLR1 and IL10RB, they activate a downstream signaling pathway remarkably similar to that of type I IFNs and share many functions with them. Yet, they also have important differences which are only now starting to unfold...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033943/human-immunodeficiency-virus-1-and-type-i-interferons-where-sex-makes-a-difference
#5
REVIEW
Susanne Maria Ziegler, Marcus Altfeld
The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women present with lower HIV-1 loads early in infection. However, the progression to AIDS for the same level of viremia is faster in women than in men...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29033906/long-non-coding-rnas-in-hepatitis-c-virus-infected-cells
#6
REVIEW
Marina Barriocanal, Puri Fortes
Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29029245/host-transcription-profile-in-nasal-epithelium-and-whole-blood-of-hospitalised-children-under-two-years-of-age-with-respiratory-syncytial-virus-infection
#7
Lien Anh Ha Do, Johann Pellet, H Rogier van Doorn, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Huu Mai Khanh Nguyen, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Bertrand De Meulder, Charles Auffray, Jorrit-Jan Hofstra, Jeremy Farrar, Juliet E Bryant, Menno de Jong, Martin L Hibberd
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29027659/a-novel-cotton-wrky-gene-ghwrky6-like-improves-salt-tolerance-by-activating-the-aba-signalling-pathway-and-scavenging-of-reactive-oxygen-species
#8
Abid Ullah, Heng Sun, Hakim, Xiyan Yang, Xianlong Zhang
WRKY transcription factors are transcriptional regulators of signalling pathways involved in biotic and abiotic stress responses. In this study, we report that ectopic expression of the GhWRKY6-like gene significantly improved salt tolerance in Arabidopsis while silencing the GhWRKY6-like increase the sensitivity to abiotic stresses in cotton. GhWRKY6-like was localized to the nucleus. Expression of GhWRKY6-like was remarkably induced by salt, ethylene glycol (PEG) and abscisic acid (ABA) treatments. For further characterization, the GhWRKY6-like gene was cloned and transformed into Arabidopsis...
October 13, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29026137/opiate-use-inhibits-tlr9-signaling-pathway-in-vivo-possible-role-in-pathogenesis-of-hiv-1-infection
#9
Yanyan Liao, Junjun Jiang, Bingyu Liang, Fumei Wei, Jiegang Huang, Peijiang Pan, Jinming Su, Bo Zhou, Ning Zang, Li Ye, Hao Liang
The molecular mechanism of opiate use promoting HIV-1 infection is not fully understood. TLR9 is expressed in many immune cells, including monocytes, macrophages, which can recognize viruses and viral products and consequently induce the production of antiviral factors and initiate immune responses. Previous studies have shown that chronic viral infections can overcome and impair TLR9 pathway. We aimed to explore whether opiate use enhances HIV infection through inhibition of TLR9 pathway via a population-based study...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024283/mechanisms-of-human-cytomegalovirus-infection-with-a-focus-on-epidermal-growth-factor-receptor-interactions
#10
REVIEW
Aline Semblano Carreira Falcão, Pedro Fernando da Costa Vasconcelos, Dorotéa de Fátima Lobato da Silva, João de Jesus Viana Pinheiro, Luiz Fábio Magno Falcão, Juarez Antonio Simões Quaresma
Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe diseases in immunocompromised individuals. It has a high prevalence worldwide that is linked with socioeconomic factors. Similar to other herpesviruses, HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. HCMV infects a broad range of cell types. This broad tropism suggests that it may use multiple receptors for host cell entry. The identification of receptors used by HCMV is essential for understanding viral pathogenesis, because these receptors mediate the early events necessary for infection...
October 11, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29021819/hiv-1-matrix-protein-p17-and-its-variants-promote-human-triple-negative-breast-cancer-cell-aggressiveness
#11
Francesca Caccuri, Francesca Giordano, Ines Barone, Pietro Mazzuca, Cinzia Giagulli, Sebastiano Andò, Arnaldo Caruso, Stefania Marsico
BACKGROUND: The introduction of cART has changed the morbidity and mortality patterns affecting HIV-infected (HIV(+)) individuals. The risk of breast cancer in HIV(+) patients has now approached the general population risk. However, breast cancer has a more aggressive clinical course and poorer outcome in HIV(+) patients than in general population, without correlation with the CD4 or virus particles count. These findings suggest a likely influence of HIV-1 proteins on breast cancer aggressiveness and progression...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29021807/c4-protein-of-sweet-potato-leaf-curl-virus-regulates-brassinosteroid-signaling-pathway-through-interaction-with-atbin2-and-affects-male-fertility-in-arabidopsis
#12
Huiping Bi, Weijuan Fan, Peng Zhang
Sweepoviruses have been identified globally and cause substantial yield losses and cultivar decline in sweet potato. This study aimed to investigate the interaction between sweepovirus and plant host by analyzing the function of the viral protein C4 of Sweet potato leaf curl virus-Jiangsu (SPLCV-JS), a sweepovirus cloned from diseased sweet potato plants in East China. Ectopic expression of the C4 in Arabidopsis altered plant development drastically with phenotypic changes including leaf curling, seedling twisting, deformation of floral tissues and reduction of pollen fertility, and seed number...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29021395/hcmv-utilizes-a-non-traditional-stat1-activation-cascade-via-signaling-through-egfr-and-integrins-to-efficiently-promote-the-motility-differentiation-and-polarization-of-infected-monocytes
#13
Donna Collins-McMillen, Emily V Stevenson, Jung Heon Kim, Byeong-Jae Lee, Stephen J Cieply, Maciej T Nogalski, Gary C Chan, Robert W Frost, Caroline R Spohn, Andrew D Yurochko
Human cytomegalovirus infects peripheral blood monocytes and triggers biological changes that promote viral dissemination and persistence. We have shown that HCMV induces a pro-inflammatory state in infected monocytes, resulting in enhanced monocyte motility and transendothelial migration, prolonged monocyte survival, and differentiation toward a long-lived M1-like macrophage phenotype. Our data indicate that HCMV triggers these changes, in the absence of de novo viral gene expression and replication, through engagement and activation of EGFR and integrins on the surface of monocytes...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29018776/impaired-cellular-energy-metabolism-contributes-to-duck-enteritis-virus-induced-autophagy-via-the-ampk-tsc2-mtor-signaling-pathway
#14
Haichang Yin, Lili Zhao, Siqi Li, Lijing Xu, Yiping Wang, Hongyan Chen
Duck enteritis virus (DEV) is a large, complex double-stranded DNA virus that induces duck embryo fibroblast (DEF) cells autophagy, which is beneficial to its own replication, but the mechanism has not been described. In this study, we showed that impaired cell energy metabolism is involved in DEV-induced autophagy, whereby ATP synthesis is disrupted in cells after DEV infection, which causes metabolic stress and activation of autophagy. Methyl pyruvate (MP) inhibited conversion of LC3I to LC3II and accumulation of GFP-LC3, which could reverse the energy loss caused by DEV infection...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29018476/recurrent-and-prolonged-infections-in-a-child-with-a-homozygous-ifih1-nonsense-mutation
#15
Maha Zaki, Michaela Thoenes, Amit Kawalia, Peter Nürnberg, Rolf Kaiser, Raoul Heller, Hanno J Bolz
In an Egyptian girl born to consanguineous parents, whole-exome sequencing (WES) identified a homozygous mutation in PHGDH, c.1273G>A (p.Val425Met), indicating 3-phosphoglycerate dehydrogenase deficiency. This diagnosis was compatible with the patient's microcephaly, severe psychomotor retardation, seizures and cataracts. However, she additionally suffered from recurrent (at least monthly) episodes of prolonged and severe chest infections requiring hospitalization, suggesting a secondary, predisposing and potentially Mendelian, condition...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29018457/pre-infestation-of-tomato-plants-by-aphids-modulates-transmission-acquisition-relationship-among-whiteflies-tomato-yellow-leaf-curl-virus-tylcv-and-plants
#16
Xiao L Tan, Ju L Chen, Giovanni Benelli, Nicolas Desneux, Xue Q Yang, Tong X Liu, Feng Ge
Herbivory defense systems in plants are largely regulated by jasmonate-(JA) and salicylate-(SA) signaling pathways. Such defense mechanisms may impact insect feeding dynamic, may also affect the transmission-acquisition relationship among virus, plants and vectoring insects. In the context of the tomato - whitefly - Tomato Yellow Leaf Curl Virus (TYLCV) biological model, we tested the impact of pre-infesting plants with a non-vector insect (aphid Myzus persicae) on feeding dynamics of a vector insect (whitefly Bemisia tabaci) as well as virus transmission-acquisition...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29018444/mucosa-associated-lymphoid-tissue-lymphoma-translocation-protein-1-positively-modulates-matrix-metalloproteinase-9-production-in-alveolar-macrophages-upon-toll-like-receptor-7-signaling-and-influenza-virus-infection
#17
Yu-Hsiang Lee, Juin-Hua Huang, Tzu-Hsuan Chang, Hung-Chih Yang, Betty A Wu-Hsieh
Influenza A virus (IAV) infection causes significant morbidity and mortality worldwide. Matrix metalloproteinase-9 (MMP-9) degrades extracellular matrix and is involved in the pathology of influenza. It has been reported that MMP-9 mediates neutrophil migration in IAV infection. Whether alveolar macrophages, the first immune cells that encounter IAV, produce MMP-9, and the mechanism of its regulation have never been investigated. As Toll-like receptor 7 (TLR7) is one of the receptors in innate immune cells that recognize IAV, we used TLR7 agonists and IAV to stimulate alveolar macrophage MH-S cells, primary macrophages, and bone marrow neutrophils...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29018427/human-cytomegalovirus-ie2-86-kda-protein-induces-sting-degradation-and-inhibits-cgamp-mediated-ifn-%C3%AE-induction
#18
Jung-Eun Kim, Young-Eui Kim, Mark F Stinski, Jin-Hyun Ahn, Yoon-Jae Song
Stimulator of interferon genes (STING) is a critical signaling molecule in the innate immune response against DNA viruses by either directly sensing intracellular DNA or functioning as an adaptor molecule to activate the type I interferon (IFN) signaling pathway. We determined the functional interaction between STING and human cytomegalovirus (HCMV). A cDNA library containing 133 HCMV ORFs was screened to identify viral genes that inhibit STING-induced IFN-β promoter activation. Among the screened ORFs, UL122, which encodes the immediate-early 2 86 kDa (IE86) protein, strongly abolished STING-induced IFN-β promoter activation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29018425/phosphorylation-of-icariin-can-alleviate-the-oxidative-stress-caused-by-the-duck-hepatitis-virus-a-through-mitogen-activated-protein-kinases-signaling-pathways
#19
Wen Xiong, Wei Zhang, Wenjuan Yuan, Hongxu Du, Ke Ming, Fangke Yao, Jingying Bai, Yun Chen, Jiaguo Liu, Deyun Wang, Yuanliang Hu, Yi Wu
The duck virus hepatitis (DVH) caused by the duck hepatitis virus A (DHAV) has produced extensive economic losses to the duck industry. The currently licensed commercial vaccine has shown some defects and does not completely prevent the DVH. Accordingly, a new alternative treatment for this disease is urgently needed. Previous studies have shown that icariin (ICA) and its phosphorylated derivative (pICA) possessed good anti-DHAV effects through direct and indirect antiviral pathways, such as antioxidative stress...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29018409/innate-viral-receptor-signaling-determines-type-1-diabetes-onset
#20
REVIEW
Zachary J Morse, Marc S Horwitz
Heritable susceptibility of the autoimmune disorder, type 1 diabetes (T1D), only partially equates for the incidence of the disease. Significant evidence attributes several environmental stressors, such as vitamin D deficiency, gut microbiome, dietary antigens, and most notably virus infections in triggering the onset of T1D in these genetically susceptible individuals. Extensive epidemiological and clinical studies have provided credibility to this causal relationship. Infection by the enterovirus, coxsackievirus B, has been closely associated with onset of T1D and is considered a significant etiological agent for disease induction...
2017: Frontiers in Endocrinology
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