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https://www.readbyqxmd.com/read/29475160/immunotoxicity-of-ochratoxin-a-and-aflatoxin-b1-in-combination-is-associated-with-the-nuclear-factor-kappa-b-signaling-pathway-in-3d4-21-cells
#1
Lili Hou, Fang Gan, Xuan Zhou, Yajiao Zhou, Gang Qian, Zixuan Liu, Kehe Huang
The co-contamination of cereals, grains, crops, and animal feeds by mycotoxins is a universal problem. Humans and animals are exposed to several mycotoxins simultaneously as evidenced by extensive studies on this topic. Yet, most studies have addressed the effects of mycotoxins individually. Aflatoxin B1 and ochratoxin A can induce immunotoxicity. However, it remains unclear whether a combination of these mycotoxins aggravates immunotoxicity and the potential mechanism underlying this effect. In this study, we used the cell line 3D4/21, swine alveolus macrophages and innate immune cell...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29475134/inhibition-of-phosphodiesterase-4-by-fcpr16-protects-sh-sy5y-cells-against-mpp-induced-decline-of-mitochondrial-membrane-potential-and-oxidative-stress
#2
Jiahong Zhong, Hui Yu, Chang Huang, Qiuping Zhong, Yaping Chen, Jinfeng Xie, Zhongzhen Zhou, Jiangping Xu, Haitao Wang
Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's disease (PD). However, the underlying mechanism has not yet been well elucidated. Additionally, most of current PDE4 inhibitors produce severe nausea and vomiting response in patients, which limit their clinical application. FCPR16 is a novel PDE4 inhibitor with little emetic potential. In the present study, the neuroprotective effect and underlying mechanism of FCPR16 against cellular apoptosis induced by 1-methyl-4-phenylpyridinium (MPP+ ) were examined in SH-SY5Y cells...
February 14, 2018: Redox Biology
https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#3
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475089/the-effect-of-1-methylcyclopropene-1-mcp-on-expression-of-ethylene-receptor-genes-in-durian-pulp-during-ripening
#4
Monthathip Thongkum, Wachiraya Imsabai, Parichart Burns, Peter A McAtee, Robert J Schaffer, Andrew C Allan, Saichol Ketsa
Rapid fruit ripening is a significant problem that limits the shelf life of durian, with ethylene having a major impact on the regulation of this event. Durian treated with ethephon ripened 3 d after treatment with increased pulp total soluble solids, ethylene production of the whole fruit and decreased pulp firmness compared to the control fruit. 1-MCP treatment delayed ripening by up to 9 d with inhibited accumulation of total soluble solids, color change, softening and ethylene production. Genes related to ethylene perception (DzETR1 and DzETR2) and the signaling pathway (DzCTR1, DzEIL1 and DzEIL2) in the pulp were investigated during this process, using qPCR to quantify changes in gene transcription...
February 10, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29475072/digital-gene-expression-profiling-reveals-transcriptional-responses-to-acute-cold-stress-in-chinese-soft-shelled-turtle-pelodiscus-sinensis-juveniles
#5
Wen-Yi Zhang, Cui-Juan Niu, Bo-Jian Chen, Kenneth B Storey
Turtles are well known for their stress tolerance, including an ability to deal with temperature extremes or rapid thermal change. To know more about the comprehensive molecular basis of thermal stress responses in turtles, we assessed differentially expressed genes (DEGs) in the brain, liver and kidney of juvenile soft-shelled turtles, Pelodiscus sinensis, after acute cold stress (28 °C-8 °C acute transfer and held for 12 h) and following recovery (back to 28 °C and held for 24 h) by digital gene expression profiling...
February 20, 2018: Cryobiology
https://www.readbyqxmd.com/read/29475060/lanatoside-c-inhibits-cell-proliferation-and-induces-apoptosis-through-attenuating-wnt-%C3%AE-catenin-c-myc-signaling-pathway-in-human-gastric-cancer-cell
#6
Yudong Hu, Kaikai Yu, Gang Wang, Depeng Zhang, Chaoji Shi, Yunhe Ding, Duo Hong, Dan Zhang, Huiqiong He, Lei Sun, Jun-Nian Zheng, Shuyang Sun, Feng Qian
Gastric cancer is the third common cause of cancer mortality in the world with poor prognosis and high recurrence due to lack of effective medicines. Our studies revealed that lanatoside C, a FDA-approved cardiac glycoside, had an anti-proliferation effect on different human cancer cell lines (MKN-45; SGC-7901; HN4; MCF-7; HepG2) and gastric cell lines MKN-45 and SGC-7901 were the most sensitive cell lines to lanatoside C. MKN-45 cells treated with lanatoside C showed cell cycle arrest at G2/M phase and inhibition of cell migration...
February 20, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29475038/astaxanthin-protects-against-kainic-acid-induced-seizures-and-pathological-consequences
#7
Yi Chang, Cheng Wei Lu, Yi Jing Chen, Tzu Yu Lin, Shu Kuei Huang, Su Jane Wang
Excitotoxic damage caused by increased glutamate levels is involved in the pathogenesis of neurodegenerative diseases. Astaxanthin, a natural carotenoid with multiple health benefits, inhibits glutamate release from the brain tissue; however, whether it possesses the ability to affect glutamate-induced brain injury is unknown. The present study investigated the neuroprotective effects of astaxanthin on kainic acid (KA)-induced excitotoxicity in rats and the possible underlying intracellular signaling pathway...
February 20, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29475003/neuropathic-pain-models-caused-by-damage-to-central-or-peripheral-nervous-system
#8
REVIEW
Anil Kumar, Harshpreet Kaur, Arti Singh
Neuropathic Pain (NP) is a painful condition which is a direct consequence of a lesion or disease affecting the somatosensory system with symptoms like allodynia, hyperalgesia. It has complex pathogenesis as it involves several molecular signaling pathways, thus numerous reliable animal models are crucial to understand the underlying mechanism of NP and formulate effective management therapy. Some models like spinal cord injury, chronic constriction injury, spinal nerve ligation, chemotherapy induced peripheral neuropathy, diabetes-induced NP and many more are discussed...
October 2, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29474908/modulation-of-phase-shift-between-wnt-and-notch-signaling-oscillations-controls-mesoderm-segmentation
#9
Katharina F Sonnen, Volker M Lauschke, Julia Uraji, Henning J Falk, Yvonne Petersen, Maja C Funk, Mathias Beaupeux, Paul François, Christoph A Merten, Alexander Aulehla
How signaling dynamics encode information is a central question in biology. During vertebrate development, dynamic Notch signaling oscillations control segmentation of the presomitic mesoderm (PSM). In mouse embryos, this molecular clock comprises signaling oscillations of several pathways, i.e., Notch, Wnt, and FGF signaling. Here, we directly address the role of the relative timing between Wnt and Notch signaling oscillations during PSM patterning. To this end, we developed a new experimental strategy using microfluidics-based entrainment that enables specific control of the rhythm of segmentation clock oscillations...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29474868/active-site-c-p-loop-dynamics-modulate-substrate-binding-catalysis-oligomerization-stability-over-oxidation-and-recycling-of-2-cys-peroxiredoxins
#10
Neelagandan Kamariah, Birgit Eisenhaber, Frank Eisenhaber, Gerhard Grüber
Peroxiredoxins (Prxs) catalyse the rapid reduction of hydrogen peroxide, organic hydroperoxide and peroxynitrite, using a fully conserved peroxidatic cysteine (CP ) located in a conserved sequence Pxxx(T/S)xxCP motif known as CP -loop. In addition, Prxs are involved in cellular signaling pathways and regulate several redox-dependent process related disease. The effective catalysis of Prxs is associated with alterations in the CP -loop between reduced, Fully Folded (FF), and oxidized, Locally Unfolded (LU) conformations, which are linked to dramatic changes in the oligomeric structure...
February 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29474834/non-immunoglobulin-scaffold-proteins-precision-tools-for-studying-protein-protein-interactions-in-cancer
#11
REVIEW
Heather L Martin, Robert Bedford, Sophie J Heseltine, Anna A Tang, Katarzyna Z Haza, Ajinkya Rao, Michael J McPherson, Darren C Tomlinson
Cancer is frequently characterised by dysregulation of the cellular signalling processes that govern proliferation, survival and attachment. Understanding such dysregulation continues to present a challenge given the importance of protein-protein interactions in intracellular processes. Exploring this protein-protein interactome requires novel tools capable of discriminating between highly homologous proteins, individual domains and post-translational modifications. This review examines the potential of scaffold-based binding proteins to fulfil these requirements...
February 20, 2018: New Biotechnology
https://www.readbyqxmd.com/read/29474799/coercion-in-the-evolution-of-plant-microbe-communication-a-perspective
#12
Shawna L Rowe, Jeffrey S Norman, Maren Friesen
Plants and microbes are dependent on chemical signals as a means of inter-kingdom communication. There are two predicted paths for the evolution of these signals. Ritualization, the evolution of signals from cues, is the oft-assumed pathway for the evolution of plant-microbe communication systems. However, plant-microbe signaling may evolve from coercive interactions as well, a process known as sensory manipulation. Here, we aim to highlight the prevalence of coercive interactions and discuss sensory manipulation in the context of plant-microbe interactions...
February 23, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29474749/mek-erk-signaling-diametrically-controls-the-stimulation-of-il-23p19-and-ebi3-expression-in-epithelial-cells-by-il-36%C3%AE
#13
Glen M Scholz, Jacqueline E Heath, Katrina A Walsh, Eric C Reynolds
Interleukin (IL)-36 (IL-36) cytokines are important regulators of mucosal homeostasis and inflammation. We previously established that oral epithelial cells strongly upregulate IL-36γ expression in response to the bacterial pathogen Porphyromonas gingivalis. Here, we have established that IL-36γ stimulates the expression of the IL-12 cytokine family members, IL-23p19 and Epstein-Barr Virus-Induced Gene 3 (EBI3), by oral epithelial cells; their expression was also selectively stimulated by IL-36α. Notably, IL-23p19 and EBI3 expression was not stimulated by P...
February 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29474747/microrna-134-inhibits-osteosarcoma-angiogenesis-and-proliferation-by-targeting-the-vegfa-vegfr1-pathway
#14
Long Zhang, Zhi Lv, Jing Xu, Chenglong Chen, Qiaofeng Ge, Pengcui Li, Dinglu Wei, Zhuangzhuang Wu, Xiaojuan Sun
The vascular endothelial growth factor (VEGF) A and vascular endothelial growth factor receptor 1 (VEGFR1) signaling is crucial for angiogenesis and progression of osteosarcoma (OS). However, the regulation of the VEGF/VEGFR1 expression is still unclear in OS. Here, we show lower levels of microRNA-134 (miR-134) in OS tissues and cells. Induction of miR-134 over-expression significantly reduced the proliferation of Saos-2 cells and their secretion of pro-angiogenic factors, but increased the frequency of apoptotic Saos-2 cells...
February 23, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29474743/csspl-functions-as-an-adaptor-between-hd-zip-iii-and-cswus-transcription-factors-regulating-anther-and-ovule-development-in-cucumber
#15
Xiaofeng Liu, Kang Ning, Gen Che, Shuangshuang Yan, Lijie Han, Ran Gu, Zheng Li, Yiqun Weng, Xiaolan Zhang
Anther and ovule genesis preconditions crop fertilization and fruit production. However, coordinative regulation of anther and ovule development and underlying molecular pathways remain largely elusive. Here, we found that SPOROCYTELESS (SPL)/NOZZLE (NZZ) expression was nearly abolished in a cucumber mutant with severely defective anther and ovule development. CsSPL was expressed specifically in the developing anthers and ovules. Knockdown of CsSPL reduced male and female fertility with malformed pollen and suppressed ovule development...
February 23, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29474681/comparative-transcriptome-analysis-reveals-an-early-gene-expression-profile-that-contributes-to-cold-resistance-in-hevea-brasiliensis-the-para-rubber-tree
#16
Han Cheng, Xiang Chen, Jialin Fang, Zewei An, Yanshi Hu, Huasun Huang
The rubber tree (Hevea brasiliensis Muell. Arg) is a tropical, perennial, woody plant that is susceptible to cold stress. In China, cold stress has been found to severely damage rubber plants in plantations in past decades. Although several Hevea clones that are resistant to cold have been developed, their cold hardiness mechanism has yet to be elucidated. For the study reported herein, we subjected the cold-resistant clone CATAS93-114 and the cold-sensitive clone Reken501 to chilling stress, and characterized their transcriptomes at 0, 2, 8 and 24 h after the start of chilling...
February 21, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29474583/ochratoxin-a-citrinin-and-deoxynivalenol-decrease-claudin-2-expression-in-mouse-rectum-cmt93-ii-cells
#17
Hideaki Nakayama, Norio Kitagawa, Takahito Otani, Hiroshi Iida, Hisashi Anan, Tetsuichiro Inai
Intestinal epithelial cells are the first targets of ingested mycotoxins, such as ochratoxin A, citrinin and deoxynivalenol. It has been reported that paracellular permeability regulated by tight junctions is modulated by several mycotoxins by reducing the expression of specific claudins and integral membrane proteins in cell-cell contacts, accompanied by increase in phosphorylation of mitogen-activated protein kinases, including extracellular signal-related kinase (ERK) 1/2, p38 and c-Jun NH2-terminal protein kinase...
February 21, 2018: Microscopy
https://www.readbyqxmd.com/read/29474521/ethnic-differences-in-tgf%C3%AE-signaling-pathway-may-contribute-to-prostate-cancer-health-disparity
#18
Bethtrice Elliott, DeAdra L Zackery, Vanessa A Eaton, Re'Josef T Jones, Fisseha Abebe, Camille C Ragin, Shafiq A Khan
Epidemiological studies show that the incidence and mortality rates of prostate cancer (PCa) are significantly higher in African-American (AA) men when compared to Caucasian (CA) men in the US. Transforming growth factor β (TGFβ) signaling pathway is linked to health disparities in African-Americans. Recent studies suggest a role of TGFβ3 in cancer metastases and its effect on the migratory and invasive behavior; however, its role in prostate cancer in African American men has not been studied. We determined the circulating levels of TGFβ3 in AA and CA men diagnosed with PCa using ELISA...
February 21, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29474442/dysregulation-of-the-ifn-%C3%AE-stat1-signaling-pathway-in-a-cell-line-model-of-large-granular-lymphocyte-leukemia
#19
Paige M Kulling, Kristine C Olson, Cait E Hamele, Mariella F Toro, Su-Fern Tan, David J Feith, Thomas P Loughran
T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflammatory environment...
2018: PloS One
https://www.readbyqxmd.com/read/29474388/function-of-the-natalisin-receptor-in-mating-of-the-oriental-fruit-fly-bactrocera-dorsalis-hendel-and-testing-of-peptidomimetics
#20
Shun-Hua Gui, Yu-Xia Pei, Li Xu, Wei-Ping Wang, Hong-Bo Jiang, Ronald J Nachman, Krzysztof Kaczmarek, Janusz Zabrocki, Jin-Jun Wang
Natalisins (NTLs) are conservative neuropeptides, which are only found in arthropods and are documented to regulate reproductive behaviors in insects. In our previous study, we have confirmed that NTLs regulate the reproductive process in an important agricultural pest, Bactrocera dorsalis (Hendel). Hence, in this study, to further confirm the in vivo function of NTL receptor (NTLR) and assess the potential of NTLR as an insecticide target, RNA interference targeting NTLR mRNA was performed. We found that mating frequencies of both males and females were reduced by RNAi-mediated knockdown of the NTLR transcript, while there was no effect on mating duration...
2018: PloS One
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