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Chris Centeno

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https://www.readbyqxmd.com/read/28838971/a-loss-of-function-splice-acceptor-variant-in-igf2-is-protective-for-type-2-diabetes
#1
Josep M Mercader, Rachel G Liao, Avery Bell, Zachary Dymek, Karol Estrada, Taru Tukiainen, Alicia Huerta-Chagoya, Hortensia Moreno-Macías, Kathleen A Jablonski, Robert L Hanson, Geoffrey A Walford, Ignasi Moran, Ling Chen, Vineeta Agarwala, María Luisa Ordoñez-Sánchez, Rosario Rodríguez-Guillen, Maribel Rodríguez-Torres, Yayoi Segura-Kato, Humberto García-Ortiz, Federico Centeno-Cruz, Francisco Barajas-Olmos, Lizz Caulkins, Sobha Puppala, Pierre Fontanillas, Amy Williams, Sílvia Bonàs-Guarch, Chris Hartl, Stephan Ripke, Katherine Tooley, Jacqueline Lane, Carlos Zerrweck, Angélica Martínez-Hernández, Emilio J Córdova, Elvia Mendoza-Caamal, Cecilia Contreras-Cubas, María E González-Villalpando, Ivette Cruz-Bautista, Liliana Muñoz-Hernández, Donaji Gómez-Velasco, Ulises Alvirde, Brian E Henderson, Lynne R Wilkens, Loic Le Marchand, Olimpia Arellano-Campos, Laura Riba, Maegan Harden, Broad Genomics Platform, Stacey Gabriel, Hanna E Abboud, Maria L Cortes, Cristina Revilla-Monsalve, Sergio Islas-Andrade, Xavier Soberon, Joanne E Curran, Christopher P Jenkinson, Ralph A DeFronzo, Donna M Lehman, Craig L Hanis, Graeme I Bell, Michael Boehnke, John Blangero, Ravindranath Duggirala, Richa Saxena, Daniel MacArthur, Jorge Ferrer, Steven A McCarroll, David Torrents, William C Knowler, Leslie J Baier, Noel Burtt, Clicerio González-Villalpando, Christopher A Haiman, Carlos A Aguilar-Salinas, Teresa Tusié-Luna, Jason Flannick, Suzanne B R Jacobs, Lorena Orozco, David Altshuler, Jose C Florez
Type 2 diabetes (T2D) affects more than 415 million people worldwide and its costs to the health care system continue to rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2D and 12,966 individuals without T2D of Latino descent. We identified a novel genetic variant in the IGF2 gene associated with ∼20% reduced risk for T2D. This variant, which has an allele frequency of 17% in the Mexican population but is rare in Europe, prevents splicing between IGF2 exons 1 and 2...
August 24, 2017: Diabetes
https://www.readbyqxmd.com/read/28782181/public-regulatory-databases-as-a-source-of-insight-for-neuromodulation-devices-stimulation-parameters
#2
REVIEW
Doe Kumsa, G Karl Steinke, Gregory F Molnar, Eric M Hudak, Fred W Montague, Shawn C Kelley, Darrel F Untereker, Alan Shi, Benjamin P Hahn, Chris Condit, Hyowon Lee, Dawn Bardot, Jose A Centeno, Victor Krauthamer, Pavel A Takmakov
OBJECTIVE: The Shannon model is often used to define an expected boundary between non-damaging and damaging modes of electrical neurostimulation. Numerous preclinical studies have been performed by manufacturers of neuromodulation devices using different animal models and a broad range of stimulation parameters while developing devices for clinical use. These studies are mostly absent from peer-reviewed literature, which may lead to this information being overlooked by the scientific community...
August 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/26726801/an-international-consensus-definition-of-the-wish-to-hasten-death-and-its-related-factors
#3
Albert Balaguer, Cristina Monforte-Royo, Josep Porta-Sales, Alberto Alonso-Babarro, Rogelio Altisent, Amor Aradilla-Herrero, Mercedes Bellido-Pérez, William Breitbart, Carlos Centeno, Miguel Angel Cuervo, Luc Deliens, Gerrit Frerich, Chris Gastmans, Stephanie Lichtenfeld, Joaquín T Limonero, Markus A Maier, Lars Johan Materstvedt, María Nabal, Gary Rodin, Barry Rosenfeld, Tracy Schroepfer, Joaquín Tomás-Sábado, Jordi Trelis, Christian Villavicencio-Chávez, Raymond Voltz
BACKGROUND: The desire for hastened death or wish to hasten death (WTHD) that is experienced by some patients with advanced illness is a complex phenomenon for which no widely accepted definition exists. This lack of a common conceptualization hinders understanding and cooperation between clinicians and researchers. The aim of this study was to develop an internationally agreed definition of the WTHD. METHODS: Following an exhaustive literature review, a modified nominal group process and an international, modified Delphi process were carried out...
2016: PloS One
https://www.readbyqxmd.com/read/26164107/testing-modern-human-out-of-africa-dispersal-models-and-implications-for-modern-human-origins
#4
Hugo Reyes-Centeno, Mark Hubbe, Tsunehiko Hanihara, Chris Stringer, Katerina Harvati
The modern human expansion process out of Africa has important implications for understanding the genetic and phenotypic structure of extant populations. While intensely debated, the primary hypotheses focus on either a single dispersal or multiple dispersals out of the continent. Here, we use the human fossil record from Africa and the Levant, as well as an exceptionally large dataset of Holocene human crania sampled from Asia, to model ancestor-descendant relationships along hypothetical dispersal routes...
October 2015: Journal of Human Evolution
https://www.readbyqxmd.com/read/21345061/assessment-for-selection-for-the-health-care-professions-and-specialty-training-consensus-statement-and-recommendations-from-the-ottawa-2010-conference
#5
David Prideaux, Chris Roberts, Kevin Eva, Angel Centeno, Peter McCrorie, Chris McManus, Fiona Patterson, David Powis, Ara Tekian, David Wilkinson
Assessment for selection in medicine and the health professions should follow the same quality assurance processes as in-course assessment. The literature on selection is limited and is not strongly theoretical or conceptual. For written testing, there is evidence of the predictive validity of Medical College Admission Test (MCAT) for medical school and licensing examination performance. There is also evidence for the predictive validity of grade point average, particularly in combination with MCAT for graduate entry but little evidence about the predictive validity of school leaver scores...
2011: Medical Teacher
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