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https://www.readbyqxmd.com/read/27911218/aberrant-t-cell-immunity-triggered-by-human-respiratory-syncytial-virus-and-human-metapneumovirus-infection
#1
Andrea E González, Margarita K Lay, Evelyn L Jara, Janyra A Espinoza, Roberto S Gómez, Jorge Soto, Claudia A Rivera, Katia Abarca, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis
Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity...
December 2, 2016: Virulence
https://www.readbyqxmd.com/read/27909646/the-neural-mechanisms-of-meditative-practices-novel-approaches-for-healthy-aging
#2
REVIEW
Bianca P Acevedo, Sarah Pospos, Helen Lavretsky
OBJECTIVES: Meditation has been shown to have physical, cognitive, and psychological health benefits that can be used to promote healthy aging. However, the common and specific mechanisms of response remain elusive due to the diverse nature of mind-body practices. METHODS: In this review, we aim to compare the neural circuits implicated in focused-attention meditative practices that focus on present-moment awareness to those involved in active-type meditative practices (e...
2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27909405/classifying-cognitive-profiles-using-machine-learning-with-privileged-information-in-mild-cognitive-impairment
#3
Hanin H Alahmadi, Yuan Shen, Shereen Fouad, Caroline Di B Luft, Peter Bentham, Zoe Kourtzi, Peter Tino
Early diagnosis of dementia is critical for assessing disease progression and potential treatment. State-or-the-art machine learning techniques have been increasingly employed to take on this diagnostic task. In this study, we employed Generalized Matrix Learning Vector Quantization (GMLVQ) classifiers to discriminate patients with Mild Cognitive Impairment (MCI) from healthy controls based on their cognitive skills. Further, we adopted a "Learning with privileged information" approach to combine cognitive and fMRI data for the classification task...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27909005/repetition-suppression-and-memory-for-faces-is-reduced-in-adults-with-autism-spectrum-conditions
#4
Michael P Ewbank, Philip J Pell, Thomas E Powell, Elisabeth A H von dem Hagen, Simon Baron-Cohen, Andrew J Calder
Autism spectrum conditions (ASC) are associated with a number of atypicalities in face processing, including difficulties in face memory. However, the neural mechanisms underlying this difficulty are unclear. In neurotypical individuals, repeated presentation of the same face is associated with a reduction in activity, known as repetition suppression (RS), in the fusiform face area (FFA). However, to date, no studies have investigated RS to faces in individuals with ASC, or the relationship between RS and face memory...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27907106/brain-transcriptional-profiles-of-male-alternative-reproductive-tactics-and-females-in-bluegill-sunfish
#5
Charlyn G Partridge, Matthew D MacManes, Rosemary Knapp, Bryan D Neff
Bluegill sunfish (Lepomis macrochirus) are one of the classic systems for studying male alternative reproductive tactics (ARTs) in teleost fishes. In this species, there are two distinct life histories: parental and cuckolder, encompassing three reproductive tactics, parental, satellite, and sneaker. The parental life history is fixed, whereas individuals who enter the cuckolder life history transition from sneaker to satellite tactic as they grow. For this study, we used RNAseq to characterize the brain transcriptome of the three male tactics and females during spawning to identify gene ontology (GO) categories and potential candidate genes associated with each tactic...
2016: PloS One
https://www.readbyqxmd.com/read/27905859/baseline-neurocognitive-performance-and-clearance-for-athletes-to-return-to-contact
#6
Breton M Asken, James R Clugston, Aliyah R Snyder, Russell M Bauer
CONTEXT:  Computerized neurocognitive assessments are commonly used to manage sport-related concussion. Variations in baseline performance may influence neurocognitive performance after injury as well as the amount of time needed for an athlete to be cleared for return to sport participation. OBJECTIVE:  To investigate the relationship between mean baseline Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) scores and postconcussion reliable decline as well as the association between postconcussion cognitive decline and days missed after injury...
December 1, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27903707/formation-of-long-term-locomotor-memories-is-associated-with-functional-connectivity-changes-in-the-cerebellar-thalamic-cortical-network
#7
Firas Mawase, Simona Bar-Haim, Lior Shmuelof
: Although motor adaptation is typically rapid, accumulating evidence shows that it is also associated with long-lasting behavioural and neuronal changes. Two processes were suggested to explain the formation of long-term motor memories: recall -- reflecting a retrieval of previous motor actions, and faster relearning -- reflecting an increased sensitivity to errors. While these manifestations of motor memories were initially demonstrated in the context of adaptation experiments in reaching, indications of long-term motor memories were also recently demonstrated in other kinds of adaptation, such as in locomotor adaptation...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903705/organization-of-the-claustrum-to-entorhinal-cortical-connection-in-mice
#8
Takuma Kitanishi, Naoki Matsuo
: The claustrum, a subcortical structure situated between the insular cortex and striatum, is reciprocally connected with almost all neocortical regions. Based on this connectivity, the claustrum has been postulated to integrate multisensory information and, in turn, coordinate widespread cortical activity. While studies have identified how sensory information is mapped onto the claustrum, the function of individual topographically-arranged claustro-cortical pathways has been little explored...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903327/auditory-vigilance-and-working-memory-in-youth-at-familial-risk-for-schizophrenia-or-affective-psychosis-in-the-harvard-adolescent-family-high-risk-study
#9
Larry J Seidman, Andrea Pousada-Casal, Silvia Scala, Eric C Meyer, William S Stone, Heidi W Thermenos, Elena Molokotos, Jessica Agnew-Blais, Ming T Tsuang, Stephen V Faraone
BACKGROUND: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin's subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27899905/effects-of-individual-differences-in-working-memory-on-plan-presentational-choices
#10
Nava Tintarev, Judith Masthoff
This paper addresses research questions that are central to the area of visualization interfaces for decision support: (RQ1) whether individual user differences in working memory should be considered when choosing how to present visualizations; (RQ2) how to present the visualization to support effective decision making and processing; and (RQ3) how to evaluate the effectiveness of presentational choices. These questions are addressed in the context of presenting plans, or sequences of actions, to users. The experiments are conducted in several domains, and the findings are relevant to applications such as semi-autonomous systems in logistics...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27898370/individual-differences-in-cognitive-functioning-predict-effectiveness-of-a-heads-up-lane-departure-warning-for-younger-and-older-drivers
#11
Nazan Aksan, Lauren Sager, Sarah Hacker, Benjamin Lester, Jeffrey Dawson, Matthew Rizzo, Kazutoshi Ebe, James Foley
The effectiveness of an idealized lane departure warning (LDW) was evaluated in an interactive fixed base driving simulator. Thirty-eight older (mean age=77years) and 40 younger drivers (mean age=35years) took four different drives/routes similar in road culture composition and hazards encountered with and without LDW. The four drives were administered over visits separated approximately by two weeks to examine changes in long-term effectiveness of LDW. Performance metrics were number of LDW activations and average correction time to each LDW...
November 26, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27897670/boosting-cognition-effects-of-multiple-session-transcranial-direct-current-stimulation-on-working-memory
#12
Lotte J Talsma, Henryk A Kroese, Heleen A Slagter
Transcranial direct current stimulation (tDCS) is a promising tool for neurocognitive enhancement. Several studies have shown that just a single session of tDCS over the left dorsolateral pFC (lDLPFC) can improve the core cognitive function of working memory (WM) in healthy adults. Yet, recent studies combining multiple sessions of anodal tDCS over lDLPFC with verbal WM training did not observe additional benefits of tDCS in subsequent stimulation sessions nor transfer of benefits to novel WM tasks posttraining...
November 29, 2016: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/27896630/the-many-faces-of-working-memory-and-short-term-storage
#13
Nelson Cowan
The topic of working memory (WM) is ubiquitous in research on cognitive psychology and on individual differences. According to one definition, it is a small amount of information kept in a temporary state of heightened accessibility; it is used in most types of communication and problem solving. Short-term storage has been defined as the passive (i.e., non-attention-based, nonstrategic) component of WM or, alternatively, as a passive store separate from an attention-based WM. Here I note that much confusion has been created by the use by various investigators of many, subtly different definitions of WM and short-term storage...
November 28, 2016: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27895602/motivational-and-behavioral-activation-as-an-adjunct-to-psychiatric-rehabilitation-for-mild-to-moderate-negative-symptoms-in-individuals-with-schizophrenia-a-proof-of-concept-pilot-study
#14
Kee-Hong Choi, Eunju Jaekal, Ga-Young Lee
Few psychosocial approaches address the negative symptoms of schizophrenia, which shares common features with depression and anxiety. Behavioral activation (BA) is effective for addressing depression and anxiety in adults with various mental disorders. Motivational interviewing (MI) has been successfully applied to address ambivalence or lack of motivation toward treatment. Motivational and behavioral activation (mBA) has been developed by incorporating the core principles from BA and MI with recent findings on the negative symptoms of schizophrenia...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27895578/cognitive-performance-patterns-in-healthy-individuals-with-substantia-nigra-hyperechogenicity-and-early-parkinson-s-disease
#15
Rezzak Yilmaz, Susanne Gräber, Benjamin Roeben, Ulrike Suenkel, Anna-Katharina von Thaler, Sebastian Heinzel, Florian G Metzger, Gerhard W Eschweiler, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Introduction: Hyperechogenicity of the substantia nigra (SN+) is a risk marker for Parkinson's disease (PD) which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD. Methods: Data of 262 healthy individuals with normal echogenicity (SN-) and 48 healthy individuals with SN+ were compared with 82 early stage PD patients using the "Consortium to Establish a Registry for Alzheimer's disease" test battery...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27894857/cytokine-induced-memory-like-differentiation-enhances-unlicensed-nk-cell-anti-leukemia-and-fc%C3%AE-riiia-triggered-responses
#16
Julia A Wagner, Melissa M Berrien-Elliott, Maximillian Rosario, Jeffrey W Leong, Brea A Jewell, Timothy Schappe, Sara Abdel-Latif, Todd A Fehniger
Cytokine-induced memory-like natural killer (NK) cells differentiate following short-term pre-activation with interleukin (IL)-12, IL-15, and IL-18 and display enhanced effector function in response to cytokines or tumor targets for weeks following the initial pre-activation. Conventional NK cell function is dependent upon a licensing signal, classically delivered by an inhibitory receptor engaging its cognate MHC class I ligand. How licensing status integrates with cytokine-induced memory-like NK cell responses is unknown...
November 25, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27893239/face-blind-for-other-race-faces-individual-differences-in-other-race-recognition-impairments
#17
Lulu Wan, Kate Crookes, Amy Dawel, Madeleine Pidcock, Ashleigh Hall, Elinor McKone
We report the existence of a previously undescribed group of people, namely individuals who are so poor at recognition of other-race faces that they meet criteria for clinical-level impairment (i.e., they are "face-blind" for other-race faces). Testing 550 participants, and using the well-validated Cambridge Face Memory Test for diagnosing face blindness, results show the rate of other-race face blindness to be nontrivial, specifically 8.1% of Caucasians and Asians raised in majority own-race countries. Results also show risk factors for other-race face blindness to include: a lack of interracial contact; and being at the lower end of the normal range of general face recognition ability (i...
November 28, 2016: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/27890688/weight-loss-is-associated-with-improvements-in-cognitive-function-among-overweight-and-obese-people-a-systematic-review-and-meta-analysis
#18
REVIEW
Nicola Veronese, Silvia Facchini, Brendon Stubbs, Claudio Luchini, Marco Solmi, Enzo Manzato, Giuseppe Sergi, Stefania Maggi, Theodore Cosco, Luigi Fontana
Whilst obesity is associated with a higher risk of cognitive impairment, the influence of weight loss on cognitive function in obese/overweight people is equivocal. We conducted a meta-analysis of randomized controlled trials (RCTs) and longitudinal studies evaluating the influence of voluntary weight loss on cognitive function in obese/overweight individuals. Articles were acquired from a systematic search of major databases from inception till 01/2016. A random effect meta-analysis of weight loss interventions (diet, physical activity, bariatric surgery) on different cognitive domains (memory, attention, executive functions, language and motor speed) was conducted...
November 24, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27890138/individual-differences-in-cardiorespiratory-measures-of-mental-workload-an-investigation-of-negative-affectivity-and-cognitive-avoidant-coping-in-pilot-candidates
#19
Mariel Grassmann, Elke Vlemincx, Andreas von Leupoldt, Omer Van den Bergh
Cardiorespiratory measures provide useful information in addition to well-established self-report measures when monitoring operator capacity. The purpose of our study was to refine the assessment of operator load by considering individual differences in personality and their associations with cardiorespiratory activation. Physiological and self-report measures were analyzed in 115 pilot candidates at rest and while performing a multiple task covering perceptual speed, spatial orientation, and working memory...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27888324/learning-to-echolocate-in-sighted-people-a-correlational-study-on-attention-working-memory-and-spatial-abilities
#20
M R Ekkel, R van Lier, B Steenbergen
Echolocation can be beneficial for the orientation and mobility of visually impaired people. Research has shown considerable individual differences for acquiring this skill. However, individual characteristics that affect the learning of echolocation are largely unknown. In the present study, we examined individual factors that are likely to affect learning to echolocate: sustained and divided attention, working memory, and spatial abilities. To that aim, sighted participants with normal hearing performed an echolocation task that was adapted from a previously reported size-discrimination task...
November 25, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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