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https://www.readbyqxmd.com/read/28431607/sigma-1-receptor-in-brain-ischemia-reperfusion-possible-role-in-the-nr2a-induced-pathway-to-regulate-brain-derived-neurotrophic-factor
#1
Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zou
Sigma-1 receptor (σ1r) activation could attenuate the learning and memory deficits in the AD model, ischemia model and others. In our previous study, the activation of σ1r increased the expression of brain-derived neurotrophic factor (BDNF), possibly through the NR2A-induced pathway, and σ1r agonists might function as neuroprotectant agents in vascular dementia. Here, we used σ1r knockout mice to confirm the role of σ1r. Furthermore, an antagonist of NR2A was first used to investigate whether the NR2A-induced pathway is the necessary link between σ1r and BDNF...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28392262/the-regulatory-effect-of-electro-acupuncture-on-the-expression-of-nmda-receptors-in-a-sci-rat-model
#2
Wen-Zhan Tu, Wen-Ci Chen, Wan Xia, Rong He, Jie Hu, Ming-Chen Jiang, Song-He Jiang
BACKGROUND: In early spinal cord injury (SCI), glutamate receptors, including N-methyl-d-aspartate (NMDA) receptors (NMDARs), are over-stimulated by excessively released glutamate. The enhanced activity of NMDARs may cause cell death by overloading calcium (Ca(2+)) into cells based on their high permeability to Ca(2+). Studies in SCI animals have shown that treatment with electro-acupuncture (EA) is able to reduce cell death and to improve functional recovery. One possible mechanism of this neuroprotective effect is that EA has regulatory effect on NMDARs...
April 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/28378360/an-increased-extrasynaptic-nmda-tone-inhibits-a-type-k-current-and-increases-excitability-of-hypothalamic-neurosecretory-neurons-in-hypertensive-rats
#3
Meng Zhang, Vinicia C Biancardi, Javier E Stern
We recently showed that a functional coupling between extrasynaptic NMDA receptors (eNMDARs) and the A-type K(+) current (IA ) influences the firing activity of hypothalamic magnocellular neurosecretory neurons (MNCs), as well as homeostatic adaptive responses to a physiological challenge. Here, we aimed to determine whether changes in the eNMDAR-IA coupling also contributed to exacerbated MNCs activity during disease states. We used a combination of patch-clamp electrophysiology and real-time PCR in MNCs in sham and renovascular hypertensive rats (RVH)...
April 5, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28355693/-influence-of-occupational-aluminum-exposure-on-cognitive-function-and-glutamate-receptor-protein-expression-in-workers
#4
P Ren, R Li, Y Z Yuan, X T Lu, Q Niu
Objective: To investigate the influence of occupational aluminum exposure on cognitive function and glutamate receptor protein expression in peripheral blood lymphocytes in workers and the possibility of glutamate receptor being used as a biomarker for cognitive impairment in aluminum workers. Methods: From October to December, 2014, cluster sampling was performed to select 121 workers in aluminum electrolysis workshop as exposure group and 231 workers in thermoelectric workshop and logistics department as control group...
February 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28336943/altered-glutamatergic-tone-reveals-two-distinct-resting-state-networks-at-the-cellular-level-in-hippocampal-sclerosis
#5
Jyotirmoy Banerjee, Aparna BanerjeeDixit, Arpna Srivastava, Bhargavi Ramanujam, Aanchal Kakkar, Chitra Sarkar, Manjari Tripathi, P Sarat Chandra
Hippocampal sclerosis (HS), the most common subset of drug-resistant epilepsy (DRE), is associated with large-scale network abnormalities, even under resting state. We studied the excitatory postsynaptic currents (EPSCs) recorded from pyramidal neurons in resected samples under resting conditions from the hippocampal and anterior temporal lobe (ATL) obtained from patients with HS (n = 14) undergoing resective surgery. We observed higher frequency and amplitude of spontaneous EPSCs in both the samples compared to non-seizure control samples...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320161/circulating-autoantibodies-against-the-nr2-peptide-of-the-nmda-receptor-are-associated-with-subclinical-brain-damage-in-hypertensive-patients-with-other-pre-existing-conditions-for-vascular-risk
#6
S González-García, A González-Quevedo, Z Hernandez-Diaz, L Alvarez Camino, M Peña-Sanchez, A Cordero-Eiriz, M Brown, J A Gaya, M Betancourt-Losa, I Fernandez-Almirall, M C Menendez-Sainz, R Fernandez-Carriera
Arterial hypertension (HT) and other vascular pre-existing conditions (PEC) generate asymptomatic brain damage which increases the occurrence of stroke and cognitive decline. The aim of this work was to explore if serum antibodies against the NR2 subunit of the NMDA receptor (NR2Ab) could predict subclinical brain damage (SBD) in hypertensive patients with PEC. Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28314129/crack-cocaine-inhalation-induces-schizophrenia-like-symptoms-and-molecular-alterations-in-mice-prefrontal-cortex
#7
Lorena Bianchine Areal, Alice Laschuk Herlinger, Fabrício Souza Pelição, Cristina Martins-Silva, Rita Gomes Wanderley Pires
Crack cocaine (crack) addiction represents a major social and health burden, especially seeing as users are more prone to engage in criminal and violent acts. Crack users show a higher prevalence of psychiatric comorbidities - particularly antisocial personality disorders - when compared to powder cocaine users. They also develop cognitive deficits related mainly to executive functions, including working memory. It is noteworthy that stimulant drugs can induce psychotic states, which appear to mimic some symptoms of schizophrenia among users...
March 6, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28304288/changes-in-synaptic-plasticity-and-glutamate-receptors-in-type-2-diabetic-kk-ay-mice
#8
Huajing Yin, Weiping Wang, Wenwen Yu, Jiang Li, Nan Feng, Ling Wang, Xiaoliang Wang
In the present study, the progressive alteration of cognition and the mechanisms of reduction in long-term potentiation (LTP) in spontaneous obese KK-Ay type 2 diabetic mice were investigated. In the study, 3-, 5-, and 7-month-old KK-Ay mice were used. The results indicated that KK-Ay mice showed cognitive deficits in the Morris water maze test beginning at the age of 3 months. LTP was significantly impaired in KK-Ay mice during whole study period (3 to 7 months). The above deficits were reversible at an early stage (3 to 5 months old) by diet intervention...
March 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28255683/modulation-of-n-methyl-d-aspartate-receptors-nmdar-bcl-2-and-c-fos-gene-expressions-on-exposure-to-individual-and-mixtures-of-low-concentration-metals-in-zebrafish-danio-rerio
#9
Samuel Jerry Cobbina, Guanghua Mao, Ting Zhao, Hai Xu, Zhen Zhang, Hongyang Liu, Yanmin Zou, Xiangyang Wu, Liuqing Yang
Currently, there is limited information on the toxicity of low concentration of metal mixtures in the environment. Of particular interest is the effect of low levels of metal mixtures on neurodevelopment of aquatic organisms. This study reports the neurological gene expressions after exposing zebrafish embryos to low concentration toxic heavy metals, 120 h post fertilization (hpf). Embryos were exposed to low concentration individual and mixtures of lead (Pb), mercury (Hg), arsenic (As), and cadmium (Cd). Quantitative real-time PCR was used to assess gene expressions...
April 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28240305/increased-pkc-activity-and-altered-gsk3%C3%AE-nmdar-function-drive-behavior-cycling-in-hint1-deficient-mice-bipolarity-or-opposing-forces
#10
Javier Garzón-Niño, María Rodríguez-Muñoz, Elsa Cortés-Montero, Pilar Sánchez-Blázquez
Mice with histidine triad nucleotide-binding protein 1 (HINT1) deletion exhibit manic-like symptoms that evolve into depressive-like behavior in response to stressful paradigms. Molecular and electrophysiological studies have indicated that HINT1(-/-) mice exhibit increased PKC, PKA, and GSK3β activities, as well as glutamate N-methyl-D-aspartate receptor (NMDAR)/α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor (AMPAR) and NR2B/NR2A subunit ratios. Pharmacological interventions stabilized their behavior but through different mechanisms...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239767/down-regulation-of-pin1-in-temporal-lobe-epilepsy-patients-and-mouse-model
#11
Lan Tang, Yanke Zhang, Guojun Chen, Yan Xiong, Xuefeng Wang, Binglin Zhu
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is a unique PPIase belonging to the parvulin family, and it isomerizes peptide bond between phospho-(Ser/Thr) and Pro. Pin1 has been linked to the pathogenesis of various human diseases; however, its exact biological functions remain unclear. The aim of the present study is to explore the expression pattern of Pin1 in patients with refractory epilepsy and in a chronic pilocarpine-induced epileptic mouse model. Using Western blot, immunofluorescence and immunoprecipitation analysis, we found that Pin1 protein was mainly distributed in neurons, demonstrated by colocalization with the dendritic marker, MAP2...
February 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28182698/prevention-of-remifentanil-induced-postoperative-hyperalgesia-by-dexmedetomidine-via-regulating-the-trafficking-and-function-of-spinal-nmda-receptors-as-well-as-pkc-and-camkii-level-in-vivo-and-in-vitro
#12
Yuan Yuan, Zhe Sun, Yi Chen, Yuxin Zheng, Ke-Liang Xie, Ying He, Zhifen Wang, Guo-Lin Wang, Yong-Hao Yu
Remifentanil-induced secondary hyperalgesia has been demonstrated in both animal experiments and clinical trials. Enhancement of N-methyl-D-aspartate (NMDA) receptor trafficking as well as protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMKII) have been reported to be involved in the induction and maintenance of central sensitization. In the current study, it was demonstrated that dexmedetomidine could prevent remifentanil-induced hyperalgesia (RIH) via regulating spinal NMDAR-PKC-Ca2+/ CaMKII pathway in vivo and in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28160495/nmda-receptor-subunit-composition-controls-dendritogenesis-of-hippocampal-neurons-through-camkii-creb-p-and-h3k27ac
#13
Fernando J Bustos, Nur Jury, Pablo Martinez, Estibaliz Ampuero, Matias Campos, Sebastian Abarzúa, Karen Jaramillo, Susanne Ibing, Muriel D Mardones, Henny Haensgen, Julia Kzhyshkowska, Maria Florencia Tevy, Rachael Neve, Magdalena Sanhueza, Lorena Varela-Nallar, Martín Montecino, Brigitte van Zundert
Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and promote plasticity, NR1NR2A receptors are mainly expressed in mature neurons and induce circuit stability. How the different subunits regulate these processes is unclear, but this is likely related to the presence of their distinct C-terminal sequences that couple different signaling proteins...
February 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28154472/autoantibodies-to-nr2a-peptide-of-the-glutamate-nmda-receptor-in-patients-with-seizure-disorders-in-neuropsychiatric-systemic-lupus-erythematosus
#14
Yan Yang, Chao Yuan, Shu-Qun Shen, Xue-Er Wang, Qing-Hua Mei, Wen-Qing Jiang, Qin Huang
Objective. Seizure disorders are one of the most disabling, life-threatening, and the least understood syndromes associated with neuropsychiatric SLE (NPSLE). N-Methyl-D-aspartate (NMDA) receptors are a subgroup of the glutamate receptor family, whose NR2A subunit was found on neuronal cells (anti-NR2A) in NPSLE patients with different types of epilepsy. The present study was conducted to determine the serum levels of anti-NR2A antibodies in a large group of SLE patients, to investigate the possible correlation between the presence of the NR2A specific antibodies and NPSLE-related seizure disorders...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28145992/different-effects-of-prenatal-stress-on-erk2-creb-bcl-2-expression-in-the-hippocampus-and-the-prefrontal-cortex-of-adult-offspring-rats
#15
Zeen Zhu, Hongli Sun, Xiaojie Gong, Hui Li
It has become increasingly evident that prenatal stress and its psychological and physiological concomitants are associated with the pathophysiology of mood disorders. However, the mechanisms underlying the prenatal stress-induced offspring's anxiety disorders remain unknown. We recently reported that prenatal stress enhanced anxiety-like behavior in adult offspring rat, and involved N-methyl-D-aspartate receptor subunits, including NR1 and NR2A. In the present research, using the same prenatal stress model, we measured the ERK2/CREB/Bcl-2 mRNA levels by real-time PCR...
January 31, 2017: Neuroreport
https://www.readbyqxmd.com/read/28108334/a-study-of-glutamate-levels-nr1-nr2a-nr2b-receptors-and-oxidative-stress-in-rat-model-of-japanese-encephalitis
#16
Prashant Singh Chauhan, Usha Kant Misra, Jayantee Kalita
There is paucity of studies on the role of glutamate excitotoxicity in cell damage in Japanese encephalitis. In this study the glutamate levels and its NMDA receptors, and oxidative stress markers in different brain regions have been evaluated and correlated with neurobehavioral changes at different time points. Twelve day old Wistar rats were inoculated with 3×10(6)pfu/ml intracerebrally. The neurobehavioral effects were evaluated by spontaneous locomotor activity (SLA), grip strength and rota rod test on 10, 33 and 48days post inoculation (dpi)...
March 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28064424/gender-related-hippocampal-proteomics-study-from-young-rats-after-chronic-unpredicted-mild-stress-exposure
#17
Lin-Na Ning, Teng Zhang, Jiang Chu, Na Qu, Li Lin, Ying-Yan Fang, Yan Shi, Peng Zeng, Er-Li Cai, Xiao-Ming Wang, Qun Wang, You-Ming Lu, Xin-Wen Zhou, Qi Zhang, Qing Tian
Clinical data have shown women are more susceptible to depression. This study was performed to identify differentially regulated proteins from hippocampus in chronic unpredicted mild stress (CUMS)-exposed male and female young rats. After 7 weeks of CUMS, depressed male (M-D) and female rats (F-D) and unstressed male (M-C) and female controls (F-C) were studied. By proteomics analysis, 74 differential proteins in F-C/M-C, 79 in F-D/M-D, 77 in F-D/F-C, and 32 in M-D/M-C were found. Further, the synapse-related proteins, cytoskeleton protein tau, and stress-related kinases in hippocampus were assayed by Western blotting...
January 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28005232/hiv-1-glycoprotein-120-enhancement-of-n-methyl-d-aspartate-nmda-receptor-mediated-excitatory-postsynaptic-currents-implications-for-hiv-1-associated-neural-injury
#18
Yan Zhou, Jianuo Liu, Huangui Xiong
It is widely accepted that human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120) plays an important role in HIV-1-induced neural injury and pathogenesis of HIV-1-associated dementia (HAND). Multiple pathways have been proposed for gp120-induced neurotoxicity, amongst is the activation of N-Methyl-D-Aspartate receptors (NMDARs). It has been shown that gp120 causes neuronal injury or death and gp120 transgenic mice exhibit neurological similarity to that of HAND, all of which can be blocked or attenuated by NMDAR antagonists...
December 22, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/27988431/clinical-utility-of-circulating-anti-n-methyl-d-aspartate-receptor-subunits-nr2a-b-antibody-for-the-diagnosis-of-neuropsychiatric-syndromes-in-systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome-an-updated-meta-analysis
#19
REVIEW
Sen Hee Tay, Anna-Marie Fairhurst, Anselm Mak
BACKGROUND/PURPOSE: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and case definitions for 19 NPSLE syndromes by the American College of Rheumatology (ACR) Committee on Research cover a wide range of NP events seen in both SLE and SS. Despite advances in the understanding of SLE and SS, NP syndromes continue to pose diagnostic challenges. Correct attribution of NP events is critical in determining the correct treatment and prognosis...
February 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27931146/d-cycloserine-restores-experience-dependent-neuroplasticity-after-traumatic-brain-injury-in-the-developing-rat-brain
#20
Naomi S Sta Maria, Maxine L Reger, Yan Cai, Mary Anne T Baquing, Floyd Buen, Aditya Ponnaluri, David A Hovda, Neil G Harris, Christopher C Giza
Traumatic brain injury (TBI) in children can cause persisting cognitive and behavioral dysfunction, and inevitably raises concerns about lost potential in these injured youth. Lateral fluid percussion injury (FPI) in weanling rats pathologically affects hippocampal N-methyl-d-aspartate receptor (NMDAR)- and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated glutamatergic neurotransmission subacutely within the first post-injury week. FPI to weanling rats has also been shown to impair enriched-environment (EE) induced enhancement of Morris water maze (MWM) learning and memory in adulthood...
April 15, 2017: Journal of Neurotrauma
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