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https://www.readbyqxmd.com/read/29665767/nano-cuo-impairs-spatial-cognition-associated-with-inhibiting-hippocampal-ltp-via-affecting-glutamatergic-neurotransmission-in-rats
#1
Xiaoliang Li, Wei Sun, Lei An
Manufactured metal nanoparticles and their applications are continuously expanding because of their unique characteristics while their increasing use may predispose to potential health problems. Several studies have reported the adverse effects of copper oxide nanoparticles (nano-CuO) relative to ecotoxicity and cell toxicity, whereas little is known about the neurotoxicity of nano-CuO. The present study aimed to examine its effects on spatial cognition, hippocampal function, and the possible mechanisms. Male Wistar rats were used to establish an animal model, and nano-CuO was administered at a dose of 0...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29616445/voluntary-exercise-during-adolescence-mitigated-negative-the-effects-of-maternal-separation-stress-on-the-depressive-like-behaviors-of-adult-male-rats-role-of-nmda-receptors
#2
Forouzan Fattahi Masrour, Maghsoud Peeri, Mohammad Ali Azarbayjani, Mir-Jamal Hosseini
Evidence indicates that experiencing early-life stress (ELS) is a risk factor for the development of mental disorders such as depression. Maternal separation stress (MS) is a valid animal model of ELS that caused to induce long-lasting effects on the brain and behaviors of animals. It hypothesized that adolescence is a critical stage in which the brain is still developing, and applying (non)pharmacological therapies in this period may attenuate the effects of ELS on the brain and behavior. Male rats were subjected to MS from postnatal day (PND) 2-14, and the stressed animals were then treated with (1) chronic fluoxetine (FLX) (5 mg/kg) and (2) voluntary running wheel exercise (RW) from PND 30, for 30 days...
April 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29616397/adenosine-augmentation-evoked-by-an-ent1-inhibitor-improves-memory-impairment-and-neuronal-plasticity-in-the-app-ps1-mouse-model-of-alzheimer-s-disease
#3
Chia-Chia Lee, Ching-Pang Chang, Chun-Jung Lin, Hsing-Lin Lai, Yu-Han Kao, Sin-Jhong Cheng, Hui-Mei Chen, Yu-Ping Liao, Emilie Faivre, Luc Buée, David Blum, Jim-Min Fang, Yijuang Chern
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and synaptic dysfunction. Adenosine is an important homeostatic modulator that controls the bioenergetic network in the brain through regulating receptor-evoked signaling pathways, bioenergetic machineries, and epigenetic-mediated gene regulation. Equilibrative nucleoside transporter 1 (ENT1) is a major adenosine transporter that recycles adenosine from the extracellular space. In the present study, we report that a small adenosine analogue (designated J4) that inhibited ENT1 prevented the decline in spatial memory in an AD mouse model (APP/PS1)...
April 4, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29593295/dexras1-is-a-homeostatic-regulator-of-exercise-dependent-proliferation-and-cell-survival-in-the-hippocampal-neurogenic-niche
#4
Pascale Bouchard-Cannon, Christopher Lowden, Dennison Trinh, Hai-Ying M Cheng
Adult hippocampal neurogenesis is highly responsive to exercise, which promotes the proliferation of neural progenitor cells and the integration of newborn granule neurons in the dentate gyrus. Here we show that genetic ablation of the small GTPase, Dexras1, suppresses exercise-induced proliferation of neural progenitors, alters survival of mitotic and post-mitotic cells in a stage-specific manner, and increases the number of mature newborn granule neurons. Dexras1 is required for exercise-triggered recruitment of quiescent neural progenitors into the cell cycle...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29481317/a-postmortem-analysis-of-nmda-ionotropic-and-group-1-metabotropic-glutamate-receptors-in-the-nucleus-accumbens-in-schizophrenia
#5
Jeremy S Lum, Samuel J Millard, Xu-Feng Huang, Lezanne Ooi, Kelly A Newell
BACKGROUND: The nucleus accumbens (NAcc) has been implicated in the pathology and treatment of schizophrenia. Recent postmortem evidence suggests a hyperglutamatergic state in the NAcc. With the present study we aimed to explore possible glutamatergic alterations in the NAcc of a large schizophrenia cohort. METHODS: We performed immunoblots on postmortem NAcc samples from 30 individuals who had schizophrenia and 30 matched controls. We examined the protein expression of primary glutamatergic receptors, including the N -methyl-D-aspartate (NMDA) receptor (NR1, NR2A and NR2B subunits) and the group 1 metabotropic glutamate receptor (mGluR1 and mGluR5; dimeric and monomeric forms)...
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29463009/docosahexaenoic-acid-helps-to-lessen-extinction-memory-in-rats
#6
Michio Hashimoto, Shahdat Hossain, Masanori Katakura, Abdullah Al Mamun, Osamu Shido
Abstract : Memory extinction is referred to as a learning process in which a conditioned response (CR) progressively reduces over time as an animal learns to uncouple a response from a stimulus. Extinction occurs when the rat is placed into a context without shock after training. Docosahexaenoic acid (DHA, C22:6, n-3) is implicated in memory formation in mammalian brains. In a two-way active shuttle-avoidance apparatus, we examined whether DHA affects the extinction memory and the expression of brain cognition-related proteins, including gastrin-releasing peptide receptor (GRPR), brain-derived neurotrophic factor receptor (BDNFR) tyrosine kinase receptor B (TrKB), and N-methyl-d-aspartate receptor (NMDAR) subunits NR2A and NR2B...
February 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29425730/high-and-low-nightly-running-behavior-associates-with-nucleus-accumbens-n-methyl-d-aspartate-receptor-nmdar-nr1-subunit-expression-and-nmdar-functional-differences
#7
Kolter B Grigsby, Cathleen M Kovarik, George E Rottinghaus, Frank W Booth
The extent to which N-Methyl-D-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in order to examine if endogenous differences in nucleus accumbens (NAc) NMDA receptor expression and function underlies the propensity for high or low motivation to voluntarily wheel-run. 12-14 week old HVR and LVR females were used to examine: 1.) NAc mRNA and protein expression of NMDA subunits NR1, NR2A and NR2B; 2...
February 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29423241/novel-rare-variations-in-genes-that-regulate-developmental-change-in-n-methyl-d-aspartate-receptor-in-patients-with-schizophrenia
#8
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Kiyoto Kasai, Chihiro Kakiuchi
The mechanism underlying the vulnerability to developing schizophrenia (SCZ) during adolescence remains elusive. Hypofunction of N-methyl-d-aspartate receptors (NMDARs) has been implicated in the pathophysiology of SCZ. During development, the composition of synaptic NMDARs dramatically changes from NR2B-containing NMDARs to NR2A-containing NMDARs through the phosphorylation of NR2B S1480 or Y1472 by CDK5, CSNK2A1, and EphB2, which plays a pivotal role in the maturation of neural circuits. We hypothesized that the dysregulation of developmental change in NMDARs could be involved in the onset of SCZ...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29382619/the-effects-of-memantine-on-glutamic-receptor-associated-nitrosative-stress-in-a-traumatic-brain-injury-rat-model
#9
Che-Chuan Wang, Hsiao-Yue Wee, Chiao-Ya Hu, Chung-Ching Chio, Jinn-Rung Kuo
BACKGROUND: The main aim of this study is to elucidate whether the neuroprotective effect of memantine, a non-competitive NMDA receptor 2B (NR2B) antagonist, affect neuronal nitrosative stress, apoptosis, and NR2B expression and ultimately improve functional outcomes. MATERIAL AND METHODS: Immediately after the onset of fluid percussion TBI, anesthetized male Sprague-Dawley rats were divided into sham-operated, TBI +vehicle, and TBI+Memantine groups. TBI rats were treated with a memantine intraperitoneal injection dose of 20 mg/kg i...
January 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29364283/a-simple-cell-based-immunofluorescence-assay-to-detect-autoantibody-against-the-n-methyl-d-aspartate-nmda-receptor-in-blood
#10
Chia-Hsiang Chen, Yu-Syuan Chang
The presence of anti-NMDA receptor autoantibody can cause various neuropsychiatric symptoms in the affected patients, termed anti-NMDA receptor autoimmune encephalitis. Detection of the specific autoantibody against the NMDA receptor in the blood or cerebrospinal fluid (CSF) is essential for the accurate diagnosis of this condition. The NMDA receptor is an ion channel protein complex that contains four subunits, including two mandatory NMDA receptor subunit 1 (NR1) and one or two NMDA receptor subunit 2A (NR2A), NMDA receptor subunit 2B (NR2B), NMDA receptor subunit 2C (NR2C), or NMDA receptor subunit 2D (NR2D)...
January 9, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29339324/oscillatory-synchronous-inhibition-in-the-basolateral-amygdala-and-its-primary-dependence-on-nr2a-containing-nmda-receptors
#11
Vassiliki Aroniadou-Anderjaska, Volodymyr I Pidoplichko, Taiza H Figueiredo, Maria F M Braga
Synchronous, rhythmic firing of GABAergic interneurons is a fundamental mechanism underlying the generation of brain oscillations, and evidence suggests that NMDA receptors (NMDARs) play a key role in oscillatory activity by regulating the activity of interneurons. Consistent with this, derangement of brain rhythms in certain neuropsychiatric disorders, notably schizophrenia and autism, is associated with NMDAR hypofunction and loss of inhibitory interneurons. In the basolateral amygdala (BLA)-dysfunction of which is involved in a host of neuropsychiatric diseases-, principal neurons display spontaneous, rhythmic "bursts" of inhibitory activity, which could potentially be involved in the orchestration of oscillations in the BLA network; here, we investigated the role of NMDARs in these inhibitory oscillations...
March 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29305627/antagonism-at-the-nr2b-subunit-of-nmda-receptors-induces-increased-connectivity-of-the-prefrontal-and-subcortical-regions-regulating-reward-behavior
#12
Natalia Gass, Robert Becker, Markus Sack, Adam J Schwarz, Jonathan Reinwald, Alejandro Cosa-Linan, Lei Zheng, Christian Clemm von Hohenberg, Dragos Inta, Andreas Meyer-Lindenberg, Wolfgang Weber-Fahr, Peter Gass, Alexander Sartorius
RATIONALE: Evidence indicates that ketamine's rapid antidepressant efficacy likely results from its antagonism of NR2B-subunit-containing NMDA receptors (NMDAR). Since ketamine equally blocks NR2A- and NR2B-containing NMDAR, and has affinity to other receptors, NR2B-selective drugs might have improved therapeutic efficiency and side effect profile. OBJECTIVES: We aimed to compare the effects of (S)-ketamine and two different types of NR2B-selective antagonists on functional brain networks in rats, in order to find common circuits, where their effects intersect, and that might explain their antidepressant action...
April 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29241709/regulation-of-pleiotrophin-and-fyn-in-the-striatum-of-rats-undergoing-l-dopa-induced-dyskinesia
#13
Gimena Gomez, Mariano D Saborido, M Alejandra Bernardi, Oscar S Gershanik, Irene R Taravini, Juan E Ferrario
L-DOPA is the gold standard pharmacological therapy for symptomatic treatment of Parkinson's disease (PD), however, its long-term use is associated with the emergence of L-DOPA-induced dyskinesia (LID). Understanding the underlying molecular mechanisms of LID is crucial for the development of newer and more effective therapeutic approaches. In previous publications, we have shown that Pleiotrophin (PTN), a developmentally regulated trophic factor, is up-regulated by L-DOPA in the striatum of dopamine denervated rats...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29241651/distinct-roles-of-prelimbic-and-infralimbic-probdnf-in-extinction-of-conditioned-fear
#14
Wei Sun, Xiaoliang Li, Lei An
Brain-derived neurotrophic factor (BDNF) has been investigated for its positive role in regulation of fear acquisition and memory. The precursor of BDNF, proBDNF, has been identified as different protein from its mature form. The prelimbic (PL) and infralimbic (IL) sub-regions of the medial prefrontal cortex (mPFC) are functionally distinct in fear behavior. However, the role of PL and IL proBDNF in fear memory is unclear. Here, through the infusion of cleavage-resistant proBDNF and its antibody, we identified the dissociable roles of PL and IL proBDNF in fear expression and extinction memory as well as explored proBDNF's potential mechanism of action...
March 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29205667/the-effect-of-postnatal-manganese-exposure-on-the-nmda-receptor-signaling-pathway-in-rat-hippocampus
#15
Lei Wang, HuanHuan Fu, Bin Liu, XiaoYan Liu, WeiWei Chen, XiaoDan Yu
Overexposure to manganese (Mn) is associated with neurological disorders in children. Evidence indicated that N-methyl-d-aspartate (NMDA) receptor signaling pathway was critical for neurobehavioral function. However, whether NMDA receptor signaling pathway contributes to Mn-induced neurotoxicity remains unknown. In this study, newborn Sprague-Dawley rats were randomly assigned to four groups exposed to 0, 10, 20, and 30 mg/kg of Mn2+ by intraperitoneal injection (n = 10/group: five males and five females)...
December 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29187078/maternal-fluoride-exposure-during-gestation-and-lactation-decreased-learning-and-memory-ability-and-glutamate-receptor-mrna-expressions-of-mouse-pups
#16
Z Sun, Y Zhang, X Xue, R Niu, J Wang
Previous investigations demonstrated that high fluoride (F) exposure may adversely affect the neurodevelopment and learning and memory ability. However, whether maternal F exposure during gestation and lactation can influence the learning, memory ability, and glutamate receptor expressions of offspring has not yet been elucidated. Hence, in the present study, maternal mice were exposed to F (25, 50, or 100 mg/L sodium fluoride (NaF) in drinking water) during gestation and lactation. Results showed that exposure to 100 mg/L NaF significantly enhanced the number of total arm entries and working memory errors of offspring in the radial arm maze test compared to the control group...
January 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29185359/gualou-guizhi-decoction-reverses-brain-damage-with-cerebral-ischemic-stroke-multi-component-directed-multi-target-to-screen-calcium-overload-inhibitors-using-combination-of-molecular-docking-and-protein-protein-docking
#17
Juan Hu, Wen-Sheng Pang, Jing Han, Kuan Zhang, Ji-Zhou Zhang, Li-Dian Chen
Stroke is a disease of the leading causes of mortality and disability across the world, but the benefits of drugs curative effects look less compelling, intracellular calcium overload is considered to be a key pathologic factor for ischemic stroke. Gualou Guizhi decoction (GLGZD), a classical Chinese medicine compound prescription, it has been used to human clinical therapy of sequela of cerebral ischemia stroke for 10 years. This work investigated the GLGZD improved prescription against intracellular calcium overload could decreased the concentration of [Ca2+ ]i in cortex and striatum neurone of MCAO rats...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29167323/prefrontal-cortical-specific-differences-in-behavior-and-synaptic-plasticity-between-adolescent-and-adult-mice
#18
Xanthippi Konstantoudaki, Kleanthi Chalkiadaki, Elisabeth Vasileiou, Katerina Kalemaki, Domna Karagogeos, Kyriaki Sidiropoulou
Adolescence is a highly vulnerable period for the emergence of major neuropsychological disorders and is characterized by decreased cognitive control and increased risk-taking behavior and novelty-seeking. The prefrontal cortex (PFC) is involved in the cognitive control of impulsive and risky behavior. Although the PFC is known to reach maturation later than other cortical areas, little information is available regarding the functional changes from adolescence to adulthood in PFC, particularly compared with other primary cortical areas...
March 1, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29161964/suicidal-ideation-in-systemic-lupus-erythematosus-nr2a-gene-polymorphism-clinical-and-psychosocial-factors
#19
R I Buji, N A Abdul Murad, L F Chan, T Maniam, M S Mohd Shahrir, M Rozita, A S Shamsul, R Mohamad Hussain, N Abdullah, R Jamal, N R Nik Jaafar
Background Systemic lupus erythematosus (SLE) patients are a high-risk population for suicide. Glutamatergic neurosystem genes have been implicated in the neurobiology of depression in SLE and suicidal behaviour in general. However, the role of glutamate receptor gene polymorphisms in suicidal behaviour among SLE patients remains unclear in the context of established clinical and psychosocial factors. We aimed to investigate the association of NR2A gene polymorphism with suicidal ideation in SLE while accounting for the interaction between clinical and psychosocial factors...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29139560/the-mammalian-circadian-clock-exhibits-chronic-ethanol-tolerance-and-withdrawal-induced-glutamate-hypersensitivity-accompanied-by-changes-in-glutamate-and-trkb-receptor-proteins
#20
Jonathan H Lindsay, Rebecca A Prosser
BACKGROUND: Alcohol tolerance and withdrawal-induced effects are criteria for alcohol use disorders listed by the DSM-V. Although tolerance and withdrawal have been studied over many decades, there is still uncertainty regarding mechanistic distinctions that characterize these different forms of ethanol (EtOH)-induced plasticity. Previously, we demonstrated that the suprachiasmatic nucleus (SCN) circadian clock develops both acute and rapid tolerance to EtOH inhibition of glutamate-induced circadian phase shifts...
February 2018: Alcoholism, Clinical and Experimental Research
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