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https://www.readbyqxmd.com/read/28432828/quantitative-contrast-enhanced-spectral-mammography-based-on-photon-counting-detectors-a-feasibility-study
#1
Huanjun Ding, Sabee Molloi
PURPOSE: To investigate the feasibility of accurate quantification of iodine mass thickness in contrast-enhanced spectral mammography. MATERIALS AND METHODS: A computer simulation model was developed to evaluate the performance of a photon-counting spectral mammography system in the application of contrast-enhanced spectral mammography. A figure-of-merit (FOM), which was defined as the decomposed iodine signal-to-noise ratio (SNR) with respect to the square root of the mean glandular dose (MGD), was chosen to optimize the imaging parameters, in terms of beam energy, splitting energy, and pre-filtrations for breasts of various thicknesses and densities...
April 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28432491/anti-biofilm-activity-of-polyazolidinammonium-modified-with-iodine-hydrate-ions-against-microbial-biofilms-of-uropathogenic-coliform-bacteria
#2
O V Nechaeva, E I Tikhomirova, D A Zayarsky, N V Bespalova, E V Glinskaya, N F Shurshalova, B M Al Bayati, A I Babailova
The dynamics of microbial biofilm formation by standard strain and by clinical strains of uropathogenic coliform bacteria was investigated in vitro and the effect of sublethal concentrations of the polymer compound polyazolidinammonium modified with iodine hydrate ions on the initial stages of biofilm formation was assessed. Treatment of immunological plate wells with the polymeric compound prevented film formation, especially in case of clinical E. coli strain carrying FimH virulence gene.
April 21, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28430648/radioimmunotherapy-for-cd133-colonic-cancer-stem-cells-inhibits-tumor-development-in-nude-mice
#3
Dinghu Weng, Xueyan Jin, Saimei Qin, Xiaoli Lan, Chong Chen, Xun Sun, Xianliang She, Changling Dong, Rui An
Accumulating evidence indicates that cancer stem cells (CSCs) are the cause of tumor drug/radio-resistance or distant metastasis; therefore, it is essential to eliminate CSCs to cure cancer completely. The purpose of this study was to utilize radioimmunotherapy (RIT) to target CD133(+) colonic CSCs and observe whether this prevented tumor development, by assessing the maximum tolerated dose (MTD) of HCT116 tumor-bearing nude mice with escalating doses of 131I-AC133.1 monoclonal antibody (mAb), and determining the therapeutic efficacy of RIT with 131I-AC133...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430447/dehydrogenative-aromatic-ring-fusion-for-carbazole-synthesis-via-c-c-c-n-bond-formation-and-alkyl-migration
#4
Saikat Maiti, Prasenjit Mal
An intermolecular dehydrogenative annulation (IDA) for carbazole synthesis via sequential C-C/C-N bond formation with a selective alkyl group migration is reported. Using the hypervalent iodine(III) reagent PhI(OAc)2 (PIDA), in a one-pot operation, up to five C(sp2)-H bonds, one N(sp3)-H bond functionalization, and one alkyl (Me, Et) group migration could all be achieved from non-prefunctionalized 1,3,5-trialkylbenzenes and anilides under ambient laboratory conditions. Mechanistically, it is shown that PIDA reacts with anilides to generate a nitrenium ion or an equivalent carbenium ion which influences the second aromatic ring to be activated for C-C/C-N bond formation...
April 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28430423/hafnium-based-contrast-agents-for-x-ray-computed-tomography
#5
Markus Berger, Marcus Bauser, Thomas Frenzel, Christoph Stephan Hilger, Gregor Jost, Silvia Lauria, Bernd Morgenstern, Christian Neis, Hubertus Pietsch, Detlev Sülzle, Kaspar Hegetschweiler
Heavy-metal-based contrast agents (CAs) offer enhanced X-ray absorption for X-ray computed tomography (CT) compared to the currently used iodinated CAs. We report the discovery of new lanthanide and hafnium azainositol complexes and their optimization with respect to high water solubility and stability. Our efforts culminated in the synthesis of BAY-576, an uncharged hafnium complex with 3:2 stoichiometry and broken complex symmetry. The superior properties of this asymmetrically substituted hafnium CA were demonstrated by a CT angiography study in rabbits that revealed excellent signal contrast enhancement...
April 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28430323/povidone-iodine-3-minute-exposure-time-is-viable-in-preparation-for-cataract-surgery
#6
Chu Luan Nguyen, Lawrence J Oh, Eugene Wong, Ian C Francis
PURPOSE: Povidone-iodine (PI) is widely used to reduce the preoperative conjunctival bacterial load. This study aimed to evaluate the employment of PI 10% in an attempt to sterilize the ocular surface prior to cataract surgery, and to show that PI could be left in contact for 3 minutes. The viability of this exposure time in clinical practice, associated adverse events, and visual outcomes were documented. METHODS: In this prospective cohort study, phacoemulsification cataract surgery was performed in 604 patients by a single surgeon...
April 7, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28429941/selective-phosphoramidation-and-phosphonation-of-benzoxazoles-via-sequence-control
#7
Ling Huang, Jiuhan Gong, Zheng Zhu, Yufeng Wang, Shengmei Guo, Hu Cai
A selective phosphoramidation and phosphonation of benzoxazole was developed with trialkyl phosphites in the presence of iodine under mild conditions. In the reaction, the transformation completes in 10 min at room temperature and the substrates are well tolerant, as 2-substituted azoles could afford the quaternary carbon-centered products. Significantly, phosphites could be selectively introduced into the C- and N-positions of the benzoxazoles by controlling the addition sequence and the ratio of substrates...
April 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28429876/iodine-131-meta-iodobenzylguanidine-therapy-for-patients-with-newly-diagnosed-high-risk-neuroblastoma
#8
REVIEW
Kathelijne Cjm Kraal, Elvira C van Dalen, Godelieve Am Tytgat, Berthe Lf Van Eck-Smit
BACKGROUND: Patients with newly diagnosed high-risk (HR) neuroblastoma (NBL) still have a poor outcome, despite multi-modality intensive therapy. This poor outcome necessitates the search for new therapies, such as treatment with (131)I-meta-iodobenzylguanidine ((131)I-MIBG). OBJECTIVES: To assess the efficacy and adverse effects of (131)I-MIBG therapy in patients with newly diagnosed HR NBL. SEARCH METHODS: We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library 2016, Issue 3), MEDLINE (PubMed) (1945 to 25 April 2016) and Embase (Ovid) (1980 to 25 April 2016)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28429870/induction-of-axial-chirality-in-8-arylquinolines-via-halogenation-reactions-using-bifunctional-organocatalysts
#9
Ryota Miyaji, Keisuke Asano, Seijiro Matsubara
The enantioselective syntheses of axially chiral heterobiaryls were accomplished via the aromatic electrophilic halogenation of 3-(quinolin-8-yl)phenols using bifunctional organocatalysts, which control the molecular conformations during successive halogenations. Axially chiral quinoline derivatives, which have rarely been synthesized in an enantioselective catalytic manner, were afforded in moderate-to-good enantioselectivities via bromination, and an analogous protocol also enabled enantioselective iodination...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28429811/synthesis-and-structural-characterisation-of-the-aggregates-of-benzo-1-2-chalcogenazole-2-oxides
#10
Peter C Ho, Jamal Rafique, Jiwon Lee, Lucia M Lee, Hilary A Jenkins, James F Britten, Antonio L Braga, Ignacio Vargas-Baca
Iodine oxidation of bis[2-(hydroxyiminomethyl)phenyl] dichalcogenides yields benzo-1,2-chalcogenazole 2-oxides. Annulated derivatives of iso-tellurazole N-oxides spontaneously aggregate into cyclic tetra- and hexamers through TeO chalcogen bonding; the structures of the co-crystals with benzene and CH2Cl2 illustrate the ability of these macrocycles to interact with small guest molecules. The selenium congener crystallizes forming a supramolecular polymer. VT NMR indicates that both compounds aggregate in solution but only at low temperature in the selenium case...
April 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28428640/transforming-growth-factor-%C3%AE-plays-an-important-role-in-enhancing-wound-healing-by-topical-application-of-povidone-iodine
#11
Li Wang, Wenhan Qin, Yaying Zhou, Bin Chen, Xiaoqing Zhao, Hailin Zhao, Emma Mi, Ella Mi, Qingmei Wang, Jiaolin Ning
Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428282/whither-radioimmunotherapy-to-be-or-not-to-be
#12
Damian J Green, Oliver W Press
Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two "first-generation," directly radiolabeled anti-CD20 antibodies, (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan, were FDA-approved more than a decade ago but have been little utilized because of a variety of medical, financial, and logistic obstacles. Newer technologies employing multistep "pretargeting" methods, particularly those utilizing bispecific antibodies, have greatly enhanced the therapeutic efficacy of radioimmunotherapy and diminished its toxicities...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28427642/improvement-of-sonochemical-degradation-of-brilliant-blue-r-in-water-using-periodate-ions-implication-of-iodine-radicals-in-the-oxidation-process
#13
Oualid Hamdaoui, Slimane Merouani
In this paper, the effect of periodate (IO4(-)) on the ultrasonic degradation at 300kHz of Brilliant Blue R (BBR), an organic dye pollutant, was investigated. The experiments were realized in the absence and presence of periodate for various operating conditions including initial solution pH (2-8) and delivered ultrasonic power (20-80W). It was found that periodate greatly enhanced the sonochemical degradation of BBR. The degradation rate increased significantly with increasing IO4(-) concentration up to 10mM and decreased afterward...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28426266/physicochemical-characteristics-of-the-seed-and-seed-oil-of-the-potentially-medicinal-plant-ziziphus-oenoplia
#14
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Abhishek Madiwal, Dinesh Rajen Gerald, Mahananda Badiger, Lakshmi Kolkar, Reshma Hiremath
The proximate composition of seeds, physicochemical characteristics, and fatty acid profiles of Ziziphus oenoplia seed oil were determined in this study. The seeds possessed low moisture (4.54%) and high carbohydrate (42.96%) and protein content (40%), making the seed oil suitable for storage and consumption. The saponification value (197.80) of the seed oil makes it a promising source for the soap and shampoo industry. The iodine and saponification values are comparable to those of major edible seed oils such as groundnut and soybean...
April 20, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28424042/the-effect-of-a-new-angiographic-imaging-technology-on-radiation-dose-in-visceral-embolization-procedures
#15
Frederic Baumann, Constantino Peña, Roman Kloeckner, Barry T Katzen, Ripal Gandhi, James B Benenati
PURPOSE: To evaluate the impact of a new angiographic imaging technology on radiation dose during visceral embolization procedures involving both fluoroscopy and digital subtraction angiography. MATERIAL AND METHODS: A retrospective analysis from a single-center consecutive series of patients was performed comparing 2 angiographic imaging systems. The AlluraClarity (CIQ; Philips Healthcare, Best, the Netherlands) was used in 100 patients (n = 59 male, mean age: 70...
May 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28423990/self-assembled-nanogel-of-cholesterol-bearing-xyloglucan-as-a-drug-delivery-nanocarrier
#16
Shin-Ichi Sawada, Hiroko Yukawa, Shigeo Takeda, Yoshihiro Sasaki, Kazunari Akiyoshi
Xyloglucan (XG) is a multibranched polysaccharide consisting of a main chain β-1,4-glucan with xylose and galactose side chains. In this study, cholesterol-bearing XG (CHXG) was synthesized by the reaction of XG with cholesteryl N- (6-isocyanatohexyl) carbamate. The CHXG molecules self-assembled in water to form nanogels consisting of about 100 molecules of XG, and were characterized using differential light scattering and transmission electron microscopy. The number of cholesteryl groups per physical cross-linking site was estimated using a fluorescence quenching method...
April 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28423638/her-inhibitor-promotes-braf-mek-inhibitor-induced-redifferentiation-in-papillary-thyroid-cancer-harboring-brafv600e
#17
Lingxiao Cheng, Yuchen Jin, Min Liu, Maomei Ruan, Libo Chen
Redifferentiation therapy with BRAF/MEK inhibitors to facilitate treatment with radioiodine represents a good choice for radioiodine-refractory differentiated thyroid carcinoma, but recent initial clinical outcomes were modest. MAPK rebound caused by BRAF/MEK inhibitors-induced activation of HER2/HER3 is a resistance mechanism, and combination with HER inhibitor to prevent MAPK rebound may sensitize BRAFV600E-mutant thyroid cancer cells to redifferentiation therapy. To evaluate if inhibiting both BRAF/MEK and HER can produce stronger redifferetiation effect, we tested the effects of BRAF/MEK inhibitor dabrafenib/selumetinib alone or in combination with HER inhibitor lapatinib on the expression and function of iodine- and glucose-handling genes in BRAFV600E-positive BCPAP and K1 cells, using BHP 2-7 cells harboring RET/PTC1 rearrangement as control...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422171/nanoporous-microsphere-assembly-of-iodine-functionalised-silver-nanoparticles-as-a-novel-mini-substrate-for-enriching-and-sensing
#18
X-L Wu, H Wu, Z-M Wang, H Aizawa, J Guo, Y-H Chu
Herein, debris particulates of nanoporous silver (np-Ag) were synthesised by a dealloying method, and their integration behaviour and surface-enhanced Raman scattering (SERS) properties during iodine functionalisation were examined. It was found that the dealloyed np-Ag debris particulates gradually assembled to form rigid nanoporous microspheres comprising Ag nano-ligaments due to mechanical collisions during iodine treatment. High-resolution transmission electron microscopy and X-ray photoelectron microscopy clearly showed the iodide surface of np-Ag, which was dotted with iodine or iodide 'nanoislands'...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420409/assessing-the-status-of-iodine-deficiency-disorder-idd-and-associated-factors-in-wolaita-and-dawro-zones-school-adolescents-southern-ethiopia
#19
Shimelash Bitew Workie, Yemane Gebremariam Abebe, Amha Admasie Gelaye, Tefera Chane Mekonen
BACKGROUND: Iodine deficiency is the major preventable cause of irreversible mental retardation in the world. Ethiopia is a country with high prevalence of iodine deficiency disorders which continue to affect a large number of the country's population. The aim of the study was to assess the prevalence of iodine deficiency disorder in Wolaita and Dawuro zones. METHODS: A descriptive, cross-sectional study was conducted in high school and preparatory students in Wolaita and Dawuro zones between April and May 2012...
April 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28419319/influence-of-concentration-nanoparticle-size-beam-energy-and-material-on-dose-enhancement-in-radiation-therapy
#20
Chulhwan Hwang, Ja Mee Kim, JungHoon Kim
The purpose of this study was to analyse the effects of the type, concentration, and nanoparticle diameter of dose enhancement materials on the dose enhancement of low- and high-energy megavoltage (MV) X-rays acquired from a medical linear accelerator using Monte Carlo simulation. Monte Carlo simulation was performed with the Monte Carlo N-Particle Transport (MCNPX) code, using the energy spectrum of the linear accelerator and a mathematical Snyder head phantom. A 5-cm-diameter virtual tumour was defined in the centre of the phantom...
April 17, 2017: Journal of Radiation Research
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