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https://www.readbyqxmd.com/read/29463135/investigating-a-theatre-based-intervention-for-indigenous-youth-with-fetal-alcohol-spectrum-disorder-exploration-d-une-intervention-bas%C3%A3-e-sur-le-th%C3%A3-%C3%A3-tre-aupr%C3%A3-s-de-jeunes-autochtones-atteints-du-syndrome-d-alcoolisme-f%C3%A5-tal
#1
Michelle Keightley, Sabrina Agnihotri, Sivaniya Subramaniapillai, Julia Gray, Jennifer Keresztesi, Angela Colantonio, Helene J Polatajko, Debra Cameron, Catherine Wiseman-Hakes
BACKGROUND: Theatre-based interventions use artistic media to facilitate social and emotional awareness and have therapeutic benefits for persons with developmental disabilities and mental health problems. The role of these interventions with Indigenous youth who have emotional, behavioural, and cognitive sequelae related to fetal alcohol spectrum disorder (FASD) has not been explored. PURPOSE: The purpose of this study was to explore the experiences and acceptability of a theatre-based approach for facilitating social communication and engagement in youth with FASD...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29432031/deferred-diagnosis-in-children-assessed-for-fetal-alcohol-spectrum-disorder
#2
Katherine Flannigan, Kamaldeep Gill, Jacqueline Pei, Gail Andrew, Hasu Rajani, Audrey McFarlane, Teresa O'Riordan, Brent Symes, Carmen Rasmussen
Early intervention for individuals with FASD is paramount, thus exploring factors that affect the diagnostic process is critical. This process can be complicated by challenges gathering background information, accurately evaluating higher-level cognitive skills across ages, and teasing apart the impact of life adversities from the effects of prenatal alcohol exposure. This study is a retrospective file review of 154 children (44% female; mean age 8.4 years, range 1.0 to 16.9) deferred at their first FASD assessment, and 51 (43% female; mean 9...
February 12, 2018: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/29344313/dna-methylation-as-a-predictor-of-fetal-alcohol-spectrum-disorder
#3
Alexandre A Lussier, Alexander M Morin, Julia L MacIsaac, Jenny Salmon, Joanne Weinberg, James N Reynolds, Paul Pavlidis, Albert E Chudley, Michael S Kobor
Background: Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure. Although the North American prevalence is currently estimated at 2-5%, FASD has proven difficult to identify in the absence of the overt physical features characteristic of fetal alcohol syndrome. As interventions may have the greatest impact at an early age, accurate biomarkers are needed to identify children at risk for FASD...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29336488/neonatal-ethanol-exposure-causes-behavioral-deficits-in-young-mice
#4
Wenhua Xu, Andrew B Hawkey, Hui Li, Lu Dai, Howard H Brim, Jacqueline A Frank, Jia Luo, Susan Barron, Gang Chen
BACKGROUND: Fetal ethanol (ETOH) exposure can damage the developing central nervous system and lead to cognitive and behavioral deficits, known as fetal alcohol spectrum disorders (FASD). ETOH exposure to mouse pups during early neonatal development was used as a model of ETOH exposure that overlaps the human third trimester "brain growth spurt" - a model that has been widely used to study FASD in rats. METHODS: C57BL/6 male and female mice were exposed to ETOH (4 g/kg/day) on postnatal days (PD) 4-10 by oral intubation...
January 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29313400/gofar-improving-attention-behavior-and-adaptive-functioning-in-children-with-fetal-alcohol-spectrum-disorders-brief-report
#5
Claire D Coles, Julie A Kable, Elles Taddeo, Dorothy Strickland
OBJECTIVE: This brief report describes the GoFAR intervention designed to improve attention, behavior, and adaptive functioning in children with FASD, ages 5 to 10 years. METHODS: Thirty children were randomized to one of three conditions: GoFAR; FACELAND, and CONTROL; 25 completed the interventions. Over 10 sessions children and caregivers learned a metacognitive strategy (FAR) designed to improve cognitive control of behavior and adaptive functioning and practiced it during behavior analog therapy...
January 9, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29274031/sex-differences-in-early-postnatal-microglial-colonization-of-the-developing-rat-hippocampus-following-a-single-day-alcohol-exposure
#6
M J Ruggiero, K E Boschen, T L Roth, A Y Klintsova
Microglia are involved in various homeostatic processes in the brain, including phagocytosis, apoptosis, and synaptic pruning. Sex differences in microglia colonization of the developing brain have been reported, but have not been established following alcohol insult. Developmental alcohol exposure represents a neuroimmune challenge that may contribute to cognitive dysfunction prevalent in humans with Fetal Alcohol Spectrum Disorders (FASD) and in rodent models of FASD. Most studies have investigated neuroimmune activation following adult alcohol exposure or following multiple exposures...
December 22, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29194345/embryonic-ethanol-exposure-affects-early-and-late-added-cardiac-precursors-and-produces-long-lasting-heart-chamber-defects-in-zebrafish
#7
Swapnalee Sarmah, James A Marrs
Drinking mothers expose their fetuses to ethanol, which produces birth defects: craniofacial defects, cognitive impairment, sensorimotor disabilities and organ deformities, collectively termed as fetal alcohol spectrum disorder (FASD). Various congenital heart defects (CHDs) are present in FASD patients, but the mechanisms of alcohol-induced cardiogenesis defects are not completely understood. This study utilized zebrafish embryos and older larvae to understand FASD-associated CHDs. Ethanol-induced cardiac chamber defects initiated during embryonic cardiogenesis persisted in later zebrafish life...
December 1, 2017: Toxics
https://www.readbyqxmd.com/read/29106518/prenatal-ethanol-exposure-and-neocortical-development-a-transgenerational-model-of-fasd
#8
Charles W Abbott, David J Rohac, Riley T Bottom, Sahil Patadia, Kelly J Huffman
Fetal Alcohol Spectrum Disorders, or FASD, represent a range of adverse developmental conditions caused by prenatal ethanol exposure (PrEE) from maternal consumption of alcohol. PrEE induces neurobiological damage in the developing brain leading to cognitive-perceptual and behavioral deficits in the offspring. Alcohol-mediated alterations to epigenetic function may underlie PrEE-related brain dysfunction, with these changes potentially carried across generations to unexposed offspring. To determine the transgenerational impact of PrEE on neocortical development, we generated a mouse model of FASD and identified numerous stable phenotypes transmitted via the male germline to the unexposed third generation...
July 6, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29091739/postnatal-nutritional-treatment-of-neurocognitive-deficits-in-foetal-alcohol-spectrum-disorder-fasd
#9
Adriana Bastons-Compta, Marta Astals, Vicente Andreu, Elisabet Navarro, Oscar Garcia-Algar
Ethanol is the most important teratogen agent in humans. Prenatal alcohol exposure can lead to a wide range of adverse effects, which are broadly termed as Foetal Alcohol Spectrum Disorder (FASD). Socioeconomic status, ethnicity, differences in genetic susceptibility related to ethanol metabolism, alcohol consumption patterns, obstetric problems, maternal nutrition, stress, and other co-administered drugs are all factors that may influence FASD manifestations. Recently, much attention has been paid to the role of nutrition as a protective factor against alcohol teratogenicity...
November 1, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29023818/commentary-on-montag-et%C3%A2-al-2017-the-importance-of-cbpr-in-fasd-prevention-with-american-indian-communities
#10
Jessica D Hanson, Tess L Weber
Prenatal alcohol consumption is a public health concern due to potential lifelong physical and cognitive effects in offspring, often presenting in the form of fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). FASD is the continuum of lifelong outcomes in those born prenatally exposed to alcohol and includes a diagnosis of fetal alcohol syndrome (FAS), which is diagnosed through facial abnormalities, growth retardation, and delayed brain growth (Hoyme et al., 2016), as well as secondary disabilities such as conduct disorders, mental illness, and psychosocial functioning...
October 10, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29017910/developmental-ethanol-exposure-alters-the-morphology-of-mouse-prefrontal-neurons-in-a-layer-specific-manner
#11
Emma L Louth, Hanna D Luctkar, Kayla A Heney, Craig D C Bailey
Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent on medial prefrontal cortex (mPFC) circuitry. The objective of this study was to determine long-term effects of chronic developmental ethanol exposure on mPFC neuron morphology, in order to better-understand potential neuronal mechanisms underlying cognitive impairments associated with FASD...
October 7, 2017: Brain Research
https://www.readbyqxmd.com/read/29017023/maternal-iron-nutriture-as-a-critical-modulator-of-fasd-risk-in-alcohol-exposed-pregnancies
#12
Kaylee K Helfrich, Nipun Saini, Pamela J Kling, Susan M Smith
Alcohol consumption during pregnancy places the fetus at risk for permanent physical, cognitive, and behavioral impairments, collectively termed fetal alcohol spectrum disorders (FASD). However, prenatal alcohol exposure (PAE) outcomes vary widely, and growing evidence suggests that maternal nutrition is a modifying factor. Certain nutrients, such as iron, may modulate FASD outcomes. Untreated gestational iron deficiency (ID) causes persistent neurodevelopmental deficits in the offspring that affect many of the same domains damaged by PAE...
October 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28987617/mitigation-of-postnatal-ethanol-induced-neuroinflammation-ameliorates-trace-fear-memory-deficits-in-juvenile-rats
#13
Molly J Goodfellow, Youn Ju Shin, Derick H Lindquist
Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28977761/understanding-and-managing-sleep-disruption-in-children-with-fasd
#14
Ana Hanlon-Dearman, Maida Lynn Chen, Heather Carmichael Olson
Accumulating evidence has revealed high rates of sleep disruption among children with Fetal Alcohol Spectrum Disorder (FASD). Multiple animal and clinical studies have found a clear association between sleep problems and prenatal alcohol exposure (PAE), and recent research is beginning to characterize the types and extent of sleep disruption in FASD. Nevertheless, sleep disruption in children with FASD often goes unrecognized or is treated without referring to an evidence base. Children's disrupted sleep interferes with parental sleep and increases caregiver burden, which is of particular importance for families raising children with FASD, a group with very high levels of caregiving stress...
October 4, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28977753/the-manitoba-youth-justice-program-empowering-and-supporting-fasd-affected-youth-in-conflict-with-the-law
#15
Sally Elizabeth Longstaffe, Albert Chudley, Mary Kate Harvie, Teresa Brown, Dan Neault, Trevor John Markesteyn
Fetal Alcohol Spectrum Disorder (FASD) describes a constellation of physical, cognitive, neurologic and behavioral impairments resulting from prenatal exposure to alcohol. FASD is recognized as being one of the largest causes of preventable brain injury in children. There had long been concerns that some youth in conflict with the law may be affected with FASD given repetitive patterns of offending and apparent lack of understanding of consequences of their actions. In 2004 funding was received from Justice Canada for a pilot project with a cross departmental steering committee working together to determine a best way of working across systems to provide FASD assessments to these youth...
October 4, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28944474/altered-neural-oscillations-during-multisensory-integration-in-adolescents-with-fetal-alcohol-spectrum-disorder
#16
Alfredo D Bolaños, Brian A Coffman, Felicha T Candelaria-Cook, Piyadasa Kodituwakku, Julia M Stephen
BACKGROUND: Children with fetal alcohol spectrum disorder (FASD), who were exposed to alcohol in utero, display a broad range of sensory, cognitive, and behavioral deficits, which are broadly theorized to be rooted in altered brain function and structure. Based on the role of neural oscillations in multisensory integration from past studies, we hypothesized that adolescents with FASD would show a decrease in oscillatory power during event-related gamma oscillatory activity (30-100Hz), when compared to typically-developing healthy controls (HC), and that such decrease in oscillatory power would predict behavioral performance...
September 25, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#17
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
January 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28869026/-a-danish-fetal-alcohol-spectrum-disorders-definition
#18
Marcella Broccia, Jennifer Vikre-Jørgensen, Nete Lundager Klokker Rausgaard
The Danish Paediatric Society presents the first Danish definition of fetal alcohol spectrum disorders (FASD) in a new guideline. FASD is an umbrella term for conditions caused by prenatal alcohol exposure. To varying degrees, fetal alcohol damages manifest as physical defects, characteristic facial features and poor growth, as well as behavioural and cognitive disorders. It requires both somatic and psychological evaluation to identify these damages. Early diagnosis and identification of problems are important for prognosis as professional care has a positive preventive effect on comorbidities...
August 7, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28796950/age-related-differences-in-neuropsychological-assessment-of-fetal-alcohol-spectrum-disorder-a-cross-sectional-study
#19
Nicole Taylor, Leah Enns
This cross-sectional study examined six key areas of neuropsychological functioning (cognitive, academic, attention, executive function, adaptive skills) comparing adolescents and school-age children with prenatal alcohol exposure (PAE). The aims were: (1) to examine which neuropsychological measures were predictive of an FASD diagnosis in adolescents and school-age children with PAE, and (2) to compare the neuropsychological performance of adolescents and children diagnosed with FASD. Hierarchical logistic regressions determined that the Full-Scale IQ, Verbal Comprehension and Perceptual Reasoning indices, basic reading and math skills, adaptive functioning at school, and components of executive functioning (dependent on age) improved the probability of an accurate FASD diagnosis in both groups: 9...
August 10, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28738878/tlr4-response-mediates-ethanol-induced-neurodevelopment-alterations-in-a-model-of-fetal-alcohol-spectrum-disorders
#20
María Pascual, Jorge Montesinos, Sandra Montagud-Romero, Jerónimo Forteza, Marta Rodríguez-Arias, José Miñarro, Consuelo Guerri
BACKGROUND: Inflammation during brain development participates in the pathogenesis of early brain injury and cognitive dysfunctions. Prenatal ethanol exposure affects the developing brain and causes neural impairment, cognitive and behavioral effects, collectively known as fetal alcohol spectrum disorders (FASD). Our previous studies demonstrate that ethanol activates the innate immune response and TLR4 receptor and causes neuroinflammation, brain damage, and cognitive defects in the developmental brain stage of adolescents...
July 24, 2017: Journal of Neuroinflammation
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