Joseph L Jacobson, Tugba Akkaya-Hocagil, Sandra W Jacobson, Claire D Coles, Gale A Richardson, Heather Carmichael Olson, Nancy L Day, R Colin Carter, Neil C Dodge, Khue-Dung Dang, Richard J Cook, Louise M Ryan
BACKGROUND: Most studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose-response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose-response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency. METHODS: We performed second-order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function...
March 30, 2024: Alcohol Clin Exp Res (Hoboken)