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https://www.readbyqxmd.com/read/27736879/zinc-transporter-slc39a7-zip7-promotes-intestinal-epithelial-self-renewal-by-resolving-er-stress
#1
Wakana Ohashi, Shunsuke Kimura, Toshihiko Iwanaga, Yukihiro Furusawa, Tarou Irié, Hironori Izumi, Takashi Watanabe, Atsushi Hijikata, Takafumi Hara, Osamu Ohara, Haruhiko Koseki, Toshiro Sato, Sylvie Robine, Hisashi Mori, Yuichi Hattori, Hiroshi Watarai, Kenji Mishima, Hiroshi Ohno, Koji Hase, Toshiyuki Fukada
Zinc transporters play a critical role in spatiotemporal regulation of zinc homeostasis. Although disruption of zinc homeostasis has been implicated in disorders such as intestinal inflammation and aberrant epithelial morphology, it is largely unknown which zinc transporters are responsible for the intestinal epithelial homeostasis. Here, we show that Zrt-Irt-like protein (ZIP) transporter ZIP7, which is highly expressed in the intestinal crypt, is essential for intestinal epithelial proliferation. Mice lacking Zip7 in intestinal epithelium triggered endoplasmic reticulum (ER) stress in proliferative progenitor cells, leading to significant cell death of progenitor cells...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27725369/prevalence-and-risk-factors-for-peri-implant-diseases-in-japanese-adult-dental-patients
#2
Yorimasa Ogata, Yohei Nakayama, Junichi Tatsumi, Takehiko Kubota, Shuichi Sato, Tetsuya Nishida, Yasuo Takeuchi, Tokuya Onitsuka, Ryuji Sakagami, Takenori Nozaki, Shinya Murakami, Naritoshi Matsubara, Maki Tanaka, Toshiaki Yoshino, Junya Ota, Taneaki Nakagawa, Yuichi Ishihara, Taichi Ito, Atsushi Saito, Keiko Yamaki, Etsuko Matsuzaki, Toshirou Hidaka, Daisuke Sasaki, Takashi Yaegashi, Tadashi Yasuda, Toshiaki Shibutani, Kazuyuki Noguchi, Hisao Araki, Noriharu Ikumi, Yukihiko Aoyama, Hideki Kogai, Kenji Nemoto, Shinji Deguchi, Takashi Takiguchi, Matsuo Yamamoto, Keita Inokuchi, Takatoshi Ito, Takashi Kado, Yasushi Furuichi, Mikimoto Kanazashi, Kazuhiro Gomi, Yukie Takagi, Keita Kubokawa, Nobuo Yoshinari, Yoshiaki Hasegawa, Tetsushi Hirose, Toshinaga Sase, Hirokazu Arita, Toshiro Kodama, Kitetsu Shin, Yuichi Izumi, Hiromasa Yoshie
We investigated the prevalences and risk factors for peri-implant diseases in Japanese adult dental patients attending a follow-up visit at dental hospitals or clinics as part of their maintenance program. This cross-sectional multicenter study enrolled patients with dental implants who attended regular check-ups as part of a periodontal maintenance program during the period from October 2012 through September 2013. Patients with implants with at least 3 years of loading time were included in the study. The condition of peri-implant tissue was examined and classified into the following categories: healthy, peri-implant mucositis, and peri-implantitis...
October 7, 2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27699877/laparoendoscopic-single-site-surgeries-a-multicenter-experience-of-469-cases-in-japan
#3
Fuminori Sato, Ken Nakagawa, Akihiro Kawauchi, Akio Matsubara, Takatsugu Okegawa, Tomonori Habuchi, Koji Yoshimura, Akio Hoshi, Hidefumi Kinoshita, Akira Miyajima, Yasuyuki Naitoh, Shogo Inoue, Naoshi Itaya, Shintaro Narita, Kazuya Hanai, Kazutoshi Okubo, Masaaki Yanishi, Tadashi Matsuda, Toshiro Terachi, Hiromitsu Mimata
OBJECTIVE: To report on a multi-institutional series of non-robotic urological laparoendoscopic single-site surgery in Japan. METHODS: Consecutive cases of laparoendoscopic single-site surgery carried out between February 2009 and December 2012 at nine academic institutions were included. We examined the surgical outcomes, including conversion and complications rates. RESULTS: Four hundred and sixty-nine cases were included in the analysis...
October 4, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27698416/tissue-specific-mutation-accumulation-in-human-adult-stem-cells-during-life
#4
Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins, Isaac J Nijman, Inigo Martincorena, Michal Mokry, Caroline L Wiegerinck, Sabine Middendorp, Toshiro Sato, Gerald Schwank, Edward E S Nieuwenhuis, Monique M A Verstegen, Luc J W van der Laan, Jeroen de Jonge, Jan N M IJzermans, Robert G Vries, Marc van de Wetering, Michael R Stratton, Hans Clevers, Edwin Cuppen, Ruben van Boxtel
The gradual accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with various age-related diseases, including cancer. Extreme variation in cancer risk across tissues was recently proposed to depend on the lifetime number of ASC divisions, owing to unavoidable random mutations that arise during DNA replication. However, the rates and patterns of mutations in normal ASCs remain unknown. Here we determine genome-wide mutation patterns in ASCs of the small intestine, colon and liver of human donors with ages ranging from 3 to 87 years by sequencing clonal organoid cultures derived from primary multipotent cells...
October 3, 2016: Nature
https://www.readbyqxmd.com/read/27650679/dephosphorylated-parafibromin-is-a-transcriptional-coactivator-of-the-wnt-hedgehog-notch-pathways
#5
Ippei Kikuchi, Atsushi Takahashi-Kanemitsu, Natsuki Sakiyama, Chao Tang, Pei-Jung Tang, Saori Noda, Kazuki Nakao, Hidetoshi Kassai, Toshiro Sato, Atsu Aiba, Masanori Hatakeyama
Evolutionally conserved Wnt, Hedgehog (Hh) and Notch morphogen pathways play essential roles in the development, homeostasis and pathogenesis of multicellular organisms. Nevertheless, mechanisms that intracellularly coordinate these signal inputs remain poorly understood. Here we found that parafibromin, a component of the PAF complex, competitively interacts with β-catenin and Gli1, thereby potentiating transactivation of Wnt- and Hh-target genes in a mutually exclusive manner. Parafibromin also binds to the Notch intracellular domain (NICD), enabling concerted activation of Wnt- and Notch-target genes...
September 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27614621/a-phase-iii-multicenter-randomized-controlled-study-of-combined-androgen-blockade-with-versus-without-zoledronic-acid-in-prostate-cancer-patients-with-metastatic-bone-disease-results-of-the-zapca-trial
#6
Tomomi Kamba, Toshiyuki Kamoto, Shinichiro Maruo, Takashi Kikuchi, Yosuke Shimizu, Shunichi Namiki, Kiyohide Fujimoto, Hiroaki Kawanishi, Fuminori Sato, Shintaro Narita, Takefumi Satoh, Hideo Saito, Mikio Sugimoto, Jun Teishima, Naoya Masumori, Shin Egawa, Hideki Sakai, Yusaku Okada, Toshiro Terachi, Osamu Ogawa
OBJECTIVE: To examine the antitumor activity of zoledronic acid (ZA) combined with androgen deprivation therapy (ADT) for men with treatment-naive prostate cancer and bone metastasis. METHODS: We enrolled 227 men with treatment-naive prostate cancer and bone metastasis. Participants were randomly assigned (1:1 ratio) to receive combined androgen blockade alone (CAB group) or ZA with combined androgen blockade (CZ group). Time to treatment failure (TTTF), time to the first skeletal-related event (TTfSRE), and overall survival (OS) rates were estimated using the Kaplan-Meier method...
September 10, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27212702/a-colorectal-tumor-organoid-library-demonstrates-progressive-loss-of-niche-factor-requirements-during-tumorigenesis
#7
Masayuki Fujii, Mariko Shimokawa, Shoichi Date, Ai Takano, Mami Matano, Kosaku Nanki, Yuki Ohta, Kohta Toshimitsu, Yoshihiro Nakazato, Kenta Kawasaki, Toshio Uraoka, Toshiaki Watanabe, Takanori Kanai, Toshiro Sato
Colorectal tumor is a heterogeneous disease, with varying clinical presentation and prognosis in patients. To establish a platform encompassing this diversity, we generated 55 colorectal tumor organoid lines from a range of histological subtypes and clinical stages, including rare subtypes. Each line was defined by gene expression signatures and optimized for organoid culture according to niche factor requirements. In vitro and in xenografts, the organoids reproduced the histopathological grade and differentiation capacity of their parental tumors...
June 2, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27184401/mule-regulates-the-intestinal-stem-cell-niche-via-the-wnt-pathway-and-targets-ephb3-for-proteasomal-and-lysosomal-degradation
#8
Carmen Dominguez-Brauer, Zhenyue Hao, Andrew J Elia, Jérôme M Fortin, Robert Nechanitzky, Patrick M Brauer, Yi Sheng, Miyeko D Mana, Iok In Christine Chio, Jillian Haight, Aaron Pollett, Robert Cairns, Leanne Tworzyanski, Satoshi Inoue, Colin Reardon, Ana Marques, Jennifer Silvester, Maureen A Cox, Andrew Wakeham, Omer H Yilmaz, David M Sabatini, Johan H van Es, Hans Clevers, Toshiro Sato, Tak W Mak
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels of the receptor tyrosine kinase EphB3 by targeting it for proteasomal and lysosomal degradation. In the intestine, EphB/ephrinB interactions position cells along the crypt-villus axis and compartmentalize incipient colorectal tumors...
August 4, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27144011/instructing-students-to-measure-their-own-bone-density-and-prepare-a-simulated-health-class-during-pharmacy-school-improves-their-awareness-and-understanding-of-osteoporosis-prevention
#9
Erisa Tomishige-Mukai, Akio Kawachi, Erika Kiyohara, Fuminori Esaki, Junichiro Sonoda, Tomohiro Shinya, Keiko Narumi, Keizo Sato, Toshiro Motoya
BACKGROUND: Osteoporosis is estimated to afflict over 200 million people worldwide and healthcare professionals are needed to successfully intervene. The aim of this study was to assess cognitive changes in students pertaining to the primary prevention of osteoporosis after measuring their bone density and having them participate in a simulated health class during pharmacy school. METHODS: Third year pharmacy students participated in the training program, which consisted of measuring their bone density using quantitative ultrasound and preparing educational materials and conducting a simulated health class...
2016: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/27143627/inhibition-of-dna-methylation-suppresses-intestinal-tumor-organoids-by-inducing-an-anti-viral-response
#10
Yoshimasa Saito, Toshiaki Nakaoka, Kasumi Sakai, Toshihide Muramatsu, Kohta Toshimitsu, Masaki Kimura, Takanori Kanai, Toshiro Sato, Hidetsugu Saito
Recent studies have proposed that the major anti-tumor effect of DNA methylation inhibitors is induction of interferon-responsive genes via dsRNAs-containing endogenous retroviruses. Recently, a 3D culture system for stem cells known as organoid culture has been developed. Lgr5-positive stem cells form organoids that closely recapitulate the properties of original tissues. To investigate the effect of DNA demethylation on tumor organoids, we have established organoids from intestinal tumors of Apc(Min/+) (Min) mice and subjected them to 5-aza-2'-deoxycytidine (5-Aza-CdR) treatment and Dnmt1 knockdown...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27131256/unilateral-mandibular-condylar-osteochondroma-treated-with-ipsilateral-condylectomy-and-contralateral-ramus-osteotomy
#11
Eiji Tanaka, Chieko Shiota, Minami Sato, Shinji Fujihara, Toshiro Kondoh, Shingo Kuroda
We successfully treated a 32-year-old woman who had facial asymmetry and unilateral mandibular condylar osteochondroma using ipsilateral mandibular condylectomy and contralateral ramus osteotomy. Mirror image analysis with a noncontact 3-dimensional image scanner showed that the soft tissue on the deviated side was protruded more than 5.50 mm compared with the nondeviated side. The patient was diagnosed as having facial asymmetry with a skeletal Class III jaw-base relationship caused by unilateral mandibular condylar osteochondroma...
May 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27086994/relationship-between-3-methyl-2-4-nonanedione-concentration-and-intensity-of-light-induced-off-odor-in-soy-bean-oil
#12
Takashi Sano, Maiko Iwahashi, Jun Imagi, Toshiro Sato, Toshiyuki Yamashita, Eiichiro Fukusaki, Takeshi Bamba
A beany and green off-odor is developed in soy bean oil (SBO) under light-induced oxidative conditions. 3-Methyl-2,4-nonanedione (3-MND) was inferred as the compound responsible for the off-odor. In this study, we designed a simple quantification method for 3-MND in SBO, and evaluated the relationship between the 3-MND concentration and the intensity of the off-odor. 3-MND was analyzed by GC/MS with a thermal desorption unit system. By our method, the 3-MND concentration was found to increase with storage days and the SBO content under light exposure, and there was a high correlation between the measured 3-MND concentration and the intensity of the light-induced off-odor in SBO (R = 0...
May 1, 2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27067687/-team-approaches-for-and-future-challenges-to-promoting-perioperative-oral-management
#13
Yuka Aimono, Toshiro Kamoshida, Takafumi Nakashima, Wataru Sato, Risa Sakamoto, Yoshiko Saito, Sakiko Kikuchi, Hideyuki Ishii, Tsunehiko Maruyama, Yoshifumi Aoyama
When the medical fee system was revised in 2012, the category of perioperative oral management was newly organized. However, the calculation of additional fees for such management required referral from medical to dental departments. In addition, requests for such management were limited, possibly owing to an increased burden on doctors engaged in outpatient services. This study examined the usefulness of an approach to promote patients' use of dental services by increasing their awareness of the importance of oral management...
February 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27046831/setd7-controls-intestinal-regeneration-and-tumorigenesis-by-regulating-wnt-%C3%AE-catenin-and-hippo-yap-signaling
#14
Menno J Oudhoff, Mitchell J S Braam, Spencer A Freeman, Denise Wong, David G Rattray, Jia Wang, Frann Antignano, Kimberly Snyder, Ido Refaeli, Michael R Hughes, Kelly M McNagny, Michael R Gold, Cheryl H Arrowsmith, Toshiro Sato, Fabio M V Rossi, John H Tatlock, Dafydd R Owen, Peter J Brown, Colby Zaph
Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal cancers, while dysregulation of the Hippo/Yes-Associated Protein (YAP) pathway is an emerging regulator of intestinal tumorigenesis. In addition, these closely related pathways play a central role during intestinal regeneration. We have previously shown that methylation of the Hippo transducer YAP by the lysine methyltransferase SETD7 controls its subcellular localization and function...
April 4, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27019130/isolation-of-vascular-smooth-muscle-antigen-reactive-cd4-%C3%AE-%C3%AE-th1-clones-that-induce-pulmonary-vasculitis-in-mrl-mp-fas-mice
#15
Yoshimasa Fujita, Takao Fujii, Hironori Shimizu, Tomomi Sato, Takuji Nakamura, Haruka Iwao, Akio Nakajima, Miyuki Miki, Tomoyuki Sakai, Takafumi Kawanami, Masao Tanaka, Yasufumi Masaki, Toshihiro Fukushima, Toshiro Okazaki, Hisanori Umehara, Tsuneyo Mimori
Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), MV1b4 (Vβ4), MV1b8.3 (Vβ8.3), MV1b61 (Vβ6), MV1b62 (Vβ6), and MV1b63 (Vβ6), were isolated from the MV1 T cell line from the regional lymph nodes of immunized MRL/Mp-Fas(+/+) mice; the three (Vβ6) clones had unique CDR3 amino acid sequences. Following stimulation with VSMAg-pulsed antigen presenting cells, MV1b61 and MV1b62 failed to secrete interferon-γ and tumor necrosis factor-α, although the other four clones secreted high levels of both cytokines...
May 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27009505/effects-of-modified-atmosphere-packaging-food-life-extenders-and-temperature-on-the-shelf-life-of-ready-made-dishes
#16
Jun Sato, Takuya Maenishi, Yuki Saito, Toshiro Masuda, Naoki Kadotani, Hiroshi Kozakai, Masanori Ito
The combined effect of several microbial control factors including gas barrier of containers, modified atmosphere packaging, food life extenders and storage temperature was discussed in order to determine the possibility for improving the shelf life for hamburger steak and deepfried chicken, representative ready-made dishes sold at convenience stores in Japan. Multiple measures including cold storage were effective in improving the shelf life of ready-made dishes. It was also suggested that storage tests for ready-made dishes should be conducted at 10℃, a practical temperature, to confirm the storable period, as well as at 15℃, an adequate abuse temperature, to confirm the effects of various microbial control factors...
2016: Biocontrol Science
https://www.readbyqxmd.com/read/26990860/generation-of-directly-converted-human-osteoblasts-that-are-free-of-exogenous-gene-and-xenogenic-protein
#17
Kenta Yamamoto, Yoshiki Sato, Kenichi Honjo, Hiroaki Ichioka, Fumishige Oseko, Yoshihiro Sowa, Toshiro Yamamoto, Narisato Kanamura, Tsunao Kishida, Osam Mazda
Generation of osteoblasts from human somatic cells may be applicable in an effective transplantation therapy against bone diseases. Recently we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some transcription factor genes via retroviral vectors. However, retroviral vector-mediated transduction may potentially cause tumor formation from the infected cells, thus a non-viral gene transfection method may be more preferable for preparation of osteoblasts to be used for transplantation therapy...
November 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26948053/necab3-promotes-activation-of-hypoxia-inducible-factor-1-during-normoxia-and-enhances-tumourigenicity-of-cancer-cells
#18
Hiroki J Nakaoka, Toshiro Hara, Seiko Yoshino, Akane Kanamori, Yusuke Matsui, Teppei Shimamura, Hiroshi Sato, Yoshinori Murakami, Motoharu Seiki, Takeharu Sakamoto
Unlike most cells, cancer cells activate hypoxia inducible factor-1 (HIF-1) to use glycolysis even at normal oxygen levels, or normoxia. Therefore, HIF-1 is an attractive target in cancer therapy. However, the regulation of HIF-1 during normoxia is not well characterised, although Mint3 was recently found to activate HIF-1 in cancer cells and macrophages by suppressing the HIF-1 inhibitor, factor inhibiting HIF-1 (FIH-1). In this study, we analysed Mint3-binding proteins to investigate the mechanism by which Mint3 regulates HIF-1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26902720/active-and-water-soluble-form-of-lipidated-wnt-protein-is-maintained-by-a-serum-glycoprotein-afamin-%C3%AE-albumin
#19
Emiko Mihara, Hidenori Hirai, Hideki Yamamoto, Keiko Tamura-Kawakami, Mami Matano, Akira Kikuchi, Toshiro Sato, Junichi Takagi
Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays. We purified N-terminally tagged recombinant Wnt3a secreted from cells and accidentally discovered that Wnt3a co-purified with a glycoprotein afamin derived from the bovine serum included in the media. Wnt3a forms a 1:1 complex with afamin, which remains soluble in aqueous buffer after isolation, and can induce signaling in various cellular systems including the intestical stem cell growth assay...
2016: ELife
https://www.readbyqxmd.com/read/26875489/low-dose-daily-intake-of-vitamin-k-2-menaquinone-7-improves-osteocalcin-%C3%AE-carboxylation-a-double-blind-randomized-controlled-trials
#20
Naoko Inaba, Toshiro Sato, Takatoshi Yamashita
Vitamin K is essential for bone health, but the effects of low-dose vitamin K intake in Japanese subjects remain unclear. We investigated the effective minimum daily menaquinone-7 dose for improving osteocalcin γ-carboxylation. Study 1 was a double-blind, randomized controlled dose-finding trial; 60 postmenopausal women aged 50-69 y were allocated to one of four dosage group and consumed 0, 50, 100, or 200 μg menaquinone-7 daily for 4 wk, respectively, with a controlled diet in accordance with recommended daily intakes for 2010 in Japan...
2015: Journal of Nutritional Science and Vitaminology
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