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https://www.readbyqxmd.com/read/28545100/intranasal-delivery-of-a-bivalent-norovirus-vaccine-formulated-in-an-in-situ-gelling-dry-powder
#1
Jordan P Ball, Michael J Springer, Yawei Ni, Isaac Finger-Baker, Juan Martinez, Jessica Hahn, John F Suber, Ashley V DiMarco, James D Talton, Ronald R Cobb
The global health community is beginning to understand the burden of norovirus-associated disease, which has a significant impact in both developed and developing countries. Norovirus virus like particle (VLP)-based vaccines are currently under development and have been shown to elicit systemic and mucosal immune responses when delivered intranasally. In the present study, we describe the use of a dry powder formulation (GelVac™) with an in situ gelling polysaccharide (GelSite™) extracted from Aloe vera for nasal delivery of a bivalent vaccine formulation containing both GI and GII...
2017: PloS One
https://www.readbyqxmd.com/read/28544635/a-robust-water-based-functional-binder-framework-for-high-energy-lithium-sulfur-batteries
#2
Matthew James Lacey, Viking Österlund, Fabian Jeschull, Andreas Bergfelt, Tim Bowden, Daniel Brandell
We report here a water-based functional binder framework for the lithium-sulfur battery system, based on the general combination of a polyether and an amide-containing polymer. These binders are applied here to positive electrodes optimised towards high energy electrochemical performance based only on commercially available materials. Electrodes with up to 4 mAh cm-2 capacity and 97 - 98% coulombic efficiency are achievable in electrodes with a 65% total sulfur content and a poly(ethylene oxide):poly(vinylpyrrolidone) (PEO:PVP) binder system...
May 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28544585/effects-of-ophthalmologic-solutions-on-sinonasal-ciliated-epithelium
#3
Alan D Workman, Ryan M Carey, Michael A Kohanski, Nithin D Adappa, James N Palmer, Noam A Cohen
BACKGROUND: Off-label use of topical ophthalmologic formulations for treatment of rhinologic disease is cited in recent literature and is anecdotally prevalent among practicing otolaryngologists. Steroids, antibiotics, and other drugs designed for ocular use have subjective clinical efficacy in the nose and sinuses, but their specific effects on the ciliated epithelium are less well defined. This study examines 9 commercially available ophthalmologic drug formulations for effects on ciliary motility in sinonasal cultures, in an effort to characterize their utility as topical therapies for sinonasal diseases...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544570/relative-susceptibility-of-airway-organisms-to-antimicrobial-effects-of-nitric-oxide
#4
Alan D Workman, Ryan M Carey, Michael A Kohanski, David W Kennedy, James N Palmer, Nithin D Adappa, Noam A Cohen
BACKGROUND: Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathogens to NO at physiologic concentrations. In this study we evaluated the effects of NO on 4 common airway bacteria and 1 fungus, and examined the potential implications of discrepancies in sensitivity...
May 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28544533/efficacy-and-safety-of-secukinumab-in-asian-patients-with-active-ankylosing-spondylitis-52-week-pooled-results-from-two-phase-3-studies
#5
James C-C Wei, Dominique Baeten, Joachim Sieper, Atul Deodhar, Vaishali Bhosekar, Ruvie Martin, Brian Porter
AIM: To evaluate efficacy and safety of secukinumab in Asian patients with active ankylosing spondylitis (AS) via a pooled subgroup analysis from two phase 3 studies, MEASURE 1 (NCT01358175) and MEASURE 2 (NCT01649375). METHODS: In MEASURE 1, patients were randomized to intravenous secukinumab 10 mg/kg or placebo at baseline, Weeks 2 and 4, followed by subcutaneous (s.c.) secukinumab 150 mg, 75 mg or placebo every 4 weeks (q4w) at Week 8. In MEASURE 2, patients were randomized to s...
May 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28544478/the-protective-role-of-physical-activity-on-type-2-diabetes-an-analysis-of-effect-modification-by-race-ethnicity
#6
William R Boyer, James R Churilla, Samantha F Ehrlich, Scott E Crouter, Lyndsey M Hornbuckle, Eugene C Fitzhugh
BACKGROUND: It is well known physical activity (PA) plays a role in the prevention of type 2 diabetes (T2D). However, the extent to which PA may impact T2D risk among different race-ethnic groups is unknown. Therefore, the purpose of this study was to systematically examine the effect modification of race-ethnicity on PA and T2D. METHODS: PubMed and Embase databases were systematically searched through June 2016. Study assessment for inclusion was conducted in three phases: 1) title review (N = 13,022), 2) abstract review (N = 2,200), and 3) full text review (N = 265)...
May 24, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28543878/mitap-compliant-characterisation-of-human-regulatory-macrophages
#7
REVIEW
James A Hutchinson, Nobert Ahrens, Edward K Geissler
This article provides a transparent description of Mreg_UKR cell products, including manufacture and quality-control processes, using the structure and vocabulary of the 'Minimum Information about Tolerogenic Antigen-presenting Cells' reporting guidelines. This information is intended as a resource for those in the field, as well as a stimulus to develop a new wave of immunoregulatory and tissue-reparative monocyte-derived cell therapies. This article is protected by copyright. All rights reserved.
May 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28543541/human-schwann-cells-exhibit-long-term-cell-survival-are-not-tumorigenic-and-promote-repair-when-transplanted-into-the-contused-spinal-cord
#8
Johana Bastidas, Gagani Athauda, Gabriela De La Cruz, Wai-Man Chan, Roozbeh Golshani, Yerko Berrocal, Martha Henao, Anil Lalwani, Chikato Mannoji, Mazen Assi, P Anthony Otero, Aisha Khan, Alexander E Marcillo, Michael Norenberg, Allan D Levi, Patrick M Wood, James D Guest, W Dalton Dietrich, Mary Bartlett Bunge, Damien D Pearse
The transplantation of rodent Schwann cells (SCs) provides anatomical and functional restitution in a variety of spinal cord injury (SCI) models, supporting the recent translation of SCs to phase 1 clinical trials for human SCI. Whereas human (Hu)SCs have been examined experimentally in a complete SCI transection paradigm, to date the reported behavior of SCs when transplanted after a clinically relevant contusive SCI has been restricted to the use of rodent SCs. Here, in a xenotransplant, contusive SCI paradigm, the survival, biodistribution, proliferation and tumorgenicity as well as host responses to HuSCs, cultured according to a protocol analogous to that developed for clinical application, were investigated...
May 22, 2017: Glia
https://www.readbyqxmd.com/read/28543401/oral-anticoagulation-management-in-patients-with-atrial-fibrillation-undergoing-cardiac-implantable-electronic-device-implantation
#9
Eric Black-Maier, Sunghee Kim, Benjamin A Steinberg, Gregg C Fonarow, James V Freeman, Peter R Kowey, Jack Ansell, Bernard J Gersh, Kenneth W Mahaffey, Gerald Naccarelli, Elaine M Hylek, Alan S Go, Eric D Peterson, Jonathan P Piccini
BACKGROUND: Oral anticoagulation (OAC) therapy is associated with increased periprocedural risks after cardiac implantable electronic device (CIED) implantation. Patterns of anticoagulation management involving non-vitamin K antagonist oral anticoagulants (NOACs) have not been characterized. HYPOTHESIS: Anticoagulation strategies and outcomes differ by anticoagulant type in patients undergoing CIED implantation. METHODS: Using the nationwide Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, we assessed how atrial fibrillation (AF) patients undergoing CIED implantation were cared for and their subsequent outcomes...
May 19, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28542833/why-are-patients-with-blood-cancers-more-likely-to-die-without-hospice
#10
Oreofe O Odejide, Angel M Cronin, Craig C Earle, James A Tulsky, Gregory A Abel
BACKGROUND: Although patients with blood cancers have significantly lower rates of hospice use than those with solid malignancies, data explaining this gap in end-of-life care are sparse. METHODS: In 2015, we conducted a mailed survey of a randomly selected sample of hematologic oncologists in the United States to characterize their perspectives regarding the utility and adequacy of hospice for blood cancer patients, as well as factors that might impact referral patterns...
May 22, 2017: Cancer
https://www.readbyqxmd.com/read/28542801/serum-protein-binding-of-25-antiepileptic-drugs-in-a-routine-clinical-setting-a-comparison-of-free-non-protein-bound-concentrations
#11
Philip N Patsalos, Miguel Zugman, Charlotte Lake, Anthony James, Neville Ratnaraj, Josemir W Sander
OBJECTIVE: Given that only the free non-protein-bound concentration of an antiepileptic drug (AED) crosses the blood-brain barrier, entering the brain and producing an antiepileptic effect, knowledge and measurement of the free drug fraction is important. Such data are sparse, particularly for newer AEDs, and have arisen from the use of disparate methodologies and settings over the past six decades. We report on the protein binding of 25 AEDs that are available for clinical use, along with two pharmacologically active metabolites (carbamazepine-epoxide and N-desmethyl clobazam), using standardized methodology and under set conditions...
May 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/28542187/elucidation-of-new-condition-dependent-roles-for-fructose-1-6-bisphosphatase-linked-to-cofactor-balances
#12
Du Toit W P Schabort, Stephanus G Kilian, James C du Preez
The cofactor balances in metabolism is of paramount importance in the design of a metabolic engineering strategy and understanding the regulation of metabolism in general. ATP, NAD+ and NADP+ balances are central players linking the various fluxes in central metabolism as well as biomass formation. NADP+ is especially important in the metabolic engineering of yeasts for xylose fermentation, since NADPH is required by most yeasts in the initial step of xylose utilisation, including the fast-growing Kluyveromyces marxianus...
2017: PloS One
https://www.readbyqxmd.com/read/28542059/common-and-critical-components-among-community-health-assessment-and-community-health-improvement-planning-models
#13
Cara L Pennel, James N Burdine, John D Prochaska, Kenneth R McLeroy
Community health assessment and community health improvement planning are continuous, systematic processes for assessing and addressing health needs in a community. Since there are different models to guide assessment and planning, as well as a variety of organizations and agencies that carry out these activities, there may be confusion in choosing among approaches. By examining the various components of the different assessment and planning models, we are able to identify areas for coordination, ways to maximize collaboration, and strategies to further improve community health...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28542003/providing-choice-in-exercise-influences-food-intake-at-the-subsequent-meal
#14
Natalya J Beer, James A Dimmock, Ben Jackson, Kym J Guelfi
The benefits of regular exercise for health are well established; however, certain behaviors following exercise, such as unhealthy or excessive food consumption, can counteract some of these benefits. PURPOSE: To investigate the effect of autonomy support (through the provision of choice) in exercise - relative to a no-choice condition with matched energy expenditure - on appetite and subsequent energy intake. METHODS: Fifty-eight men and women (body mass index: 22...
May 23, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28541431/emerging-safety-of-intramedullary-transplantation-of-human-neural-stem-cells-in-chronic-cervical-and-thoracic-spinal-cord-injury
#15
Allan D Levi, David O Okonkwo, Paul Park, Arthur L Jenkins, Shekar N Kurpad, Ann M Parr, Aruna Ganju, Bizhan Aarabi, Dong Kim, Steven Casha, Michael G Fehlings, James S Harrop, Kim D Anderson, Allyson Gage, Jane Hsieh, Stephen Huhn, Armin Curt, Raphael Guzman
BACKGROUND: Human central nervous system stem cells (HuCNS-SC) are multipotent adult stem cells with successful engraftment, migration, and region-appropriate differentiation after spinal cord injury (SCI). OBJECTIVE: To present data on the surgical safety profile and feasibility of multiple intramedullary perilesional injections of HuCNS-SC after SCI. METHODS: Intramedullary free-hand (manual) transplantation of HuCNS-SC cells was performed in subjects with thoracic (n = 12) and cervical (n = 17) complete and sensory incomplete chronic traumatic SCI...
May 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28541067/vocational-rehabilitation-for-veterans-with-felony-histories-and-mental-illness-12-month-outcomes
#16
James P LePage, Avery A Lewis, April M Crawford, Edward L Washington, Julie A Parish-Johnson, Daisha J Cipher, Ledjona D Bradshaw
Lack of employment is an important barrier to successful reintegration encountered by those released from prison with mental illnesses and/or substance use disorders. This study compares 3 different vocational reintegration modalities for a veteran population: (a) basic services; (b) self-study using the About Face Vocational Manual; and (c) the About Face Vocational Program, a standardized group program focused on the About Face Vocational Manual. One-hundred eleven veterans with a history of at least one felony conviction and a mental illness and/or substance use disorder were recruited from a large urban Veterans Affairs (VA) medical center...
May 25, 2017: Psychological Services
https://www.readbyqxmd.com/read/28540148/clinical-and-microbiological-characteristics-of-bacteroides-prosthetic-joint-infections
#17
Neel Shah, Douglas Osmon, Aaron J Tande, James Steckelberg, Rafael Sierra, Randall Walker, Elie F Berbari
Clinical and microbiological characteristics of patients with Bacteroides prosthetic joint infection (PJI) have not been well described in the literature. The aim of this retrospective cohort study was to assess the outcome of patients with Bacteroides PJI and to review risk factors associated with failure of therapy. Between 1/1969 and 12/2012, 20 episodes of Bacteroides PJI in 17 patients were identified at our institution. The mean age of the patients in this cohort at the time of diagnosis was 55.6 years; 59% (n=10) had knee involvement...
2017: J Bone Jt Infect
https://www.readbyqxmd.com/read/28539926/gene-specific-substitution-profiles-describe-the-types-and-frequencies-of-amino-acid-changes-during-antibody-somatic-hypermutation
#18
Zizhang Sheng, Chaim A Schramm, Rui Kong, James C Mullikin, John R Mascola, Peter D Kwong, Lawrence Shapiro
Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biased substitutions. To investigate the intrinsic mutation frequency and substitution bias of SHMs at the amino acid level, we analyzed functional human antibody repertoires and developed mGSSP (method for gene-specific substitution profile), a method to construct amino acid substitution profiles from next-generation sequencing-determined B cell transcripts...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28539858/relationship-between-proxies-for-type-ii-fiber-type-and-resting-blood-pressure-in-division-i-american-football-athletes
#19
Christopher A DiCesare, James R Adams, Randal P Claytor, Rose M Ward, Ronald H Cox
OBJECTIVE: The risk for cardiovascular disease is well-documented. Perhaps surprisingly, specific athletic populations, including American football players, exhibit increased risk for cardiovascular disease as presented by elevated blood pressure. There is evidence suggesting a link between muscle fiber type distribution and resting blood pressure. Acknowledging this association, it becomes important to clarify an individual's risk for developing cardiovascular disease later in adulthood...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539441/chikungunya-virus-overcomes-polyamine-depletion-by-mutation-of-nsp1-and-the-opal-stop-codon-to-confer-enhanced-replication-and-fitness
#20
Bryan C Mounce, Teresa Cesaro, Lea Vlajnić, Anna Vidiņa, Thomas Vallet, James Weger-Lucarelli, Gabriella Pasoni, Kenneth A Stapleford, Jean-Pierre Levraud, Marco Vignuzzi
Polyamines, small positively-charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral replication. However, the potential development of antiviral resistance necessitates a better understanding of how polyamines function and can be targeted via compounds that alter polyamine levels. We have isolated CHIKV that is resistant to polyamine depletion that contains two mutations in the non-structural protein 1 (nsP1) coding region in combination with mutation to the opal stop codon preceding nsP4...
May 24, 2017: Journal of Virology
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