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https://www.readbyqxmd.com/read/28937621/the-development-of-a-melt-extruded-shellac-carrier-for-the-targeted-delivery-of-probiotics-to-the-colon
#1
Noel M Gately, James E Kennedy
Hot melt extrusion (HME) is considered an efficient technique in developing solid molecular dispersions, and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. However, most commercial enteric or pH-responsive polymers are relatively difficult to process or have high Glass Transition Temperature (Tg) values, making their use with temperature-sensitive drugs, probiotics or biologics not viable. Shellac is a natural thermoplastic, and after a review of current literature on the pharmaceutical HME process, a possible gap in the knowledge of the use of shellac to produce dosage forms by means of HME was identified...
September 22, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28937044/priming-of-the-cells-hypoxic-preconditioning-for-stem-cell-therapy
#2
REVIEW
Zheng Z Wei, Yan-Bing Zhu, James Y Zhang, Myles R McCrary, Song Wang, Yong-Bo Zhang, Shan-Ping Yu, Ling Wei
OBJECTIVE: Stem cell-based therapies are promising in regenerative medicine for protecting and repairing damaged brain tissues after injury or in the context of chronic diseases. Hypoxia can induce physiological and pathological responses. A hypoxic insult might act as a double-edged sword, it induces cell death and brain damage, but on the other hand, sublethal hypoxia can trigger an adaptation response called hypoxic preconditioning or hypoxic tolerance that is of immense importance for the survival of cells and tissues...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28937015/chronic-noise-exposure-in-the-spontaneously-hypertensive-rat
#3
Anne T M Konkle, Stephen E Keith, James P McNamee, David Michaud
INTRODUCTION: Epidemiological studies have suggested an association between the relative risk for developing cardiovascular disease (CVD) and long-term exposure to elevated levels of transportation noise. The contention is that this association is largely owing to an increase in stress-related biomarkers that are thought to be associated with CVD. Animal models have demonstrated that acute noise exposure is capable of triggering a stress response; however, similar studies using chronic noise models are less common...
September 2017: Noise & Health
https://www.readbyqxmd.com/read/28936717/developing-a-typology-of-patient-generated-behavioral-goals-for-cognitive-behavioral-therapy-for-chronic-pain-cbt-cp-classification-and-predicting-outcomes
#4
Alicia A Heapy, Laura Wandner, Mary A Driscoll, Kathryn LaChappelle, Rebecca Czlapinski, Brenda T Fenton, John D Piette, James E Aikens, Mary R Janevic, Robert D Kerns
Patient-generated treatment goals describe what patients value, yet the content of these goals, and the relationship among goal types, goal accomplishment, and treatment outcomes has received little examination. We used inductive sorting to categorize patient-generated goals made by 147 adults receiving cognitive-behavioral therapy for chronic pain. The resulting goal categories were: Physical Activity (29.0%), Functional Status (24.6%), Wellness (16.3%), Recreational Activities (11.3%), House/Yard Work (9...
September 21, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28936426/comparison-of-diabetic-and-non-diabetic-human-leukocytic-responses-to-different-capsule-types-of-klebsiella-pneumoniae-responsible-for-causing-pyogenic-liver-abscess
#5
I Russel Lee, Ethel Sng, Kok-Onn Lee, James S Molton, Monica Chan, Shirin Kalimuddin, Ezlyn Izharuddin, David C Lye, Sophia Archuleta, Yunn-Hwen Gan
The major risk factor for Klebsiella liver abscess (KLA) is type 2 diabetes mellitus (DM), but the immunological mechanisms involved in the increased susceptibility are poorly defined. We investigated the responses of neutrophils and peripheral blood mononuclear cells (PBMCs) to hypervirulent Klebsiella pneumoniae (hvKP), the causative agent of KLA. DNA and myeloperoxidase levels were elevated in the plasma of KLA patients compared to uninfected individuals indicating neutrophil activation, but diabetic status had no effect on these neutrophil extracellular trap (NET) biomarkers in both subject groups...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28935639/isolation-and-characterization-of-endothelial-to-mesenchymal-transition-cells-in-pulmonary-arterial-hypertension
#6
Toshio Suzuki, Erica J Carrier, Megha A Talati, Anandharajan Rathinasabapathy, Xinping Chen, Rintaro Nishimura, Yuji Tada, Koichiro Tatsumi, James D West
Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose polarity and cell-to-cell contacts, and undergo a dramatic remodeling of the cytoskeleton. It has been implicated in initiation and progression of pulmonary arterial hypertension (PAH). However, the characteristics of cells which have undergone EndMT-cells in vivo have not been reported and so remain unclear. To study this, sugen5416 and hypoxia (SuHx)-induced PAH was established in Cdh5-Cre / Gt(ROSA)26Sor(tm4(ACTB-tdTomato,-EGFP)Luo)/J double-transgenic mice, in which GFP was stably expressed in pan-endothelial cells...
September 21, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28935363/seagrass-ecosystem-trajectory-depends-on-the-relative-timescales-of-resistance-recovery-and-disturbance
#7
Katherine R O'Brien, Michelle Waycott, Paul Maxwell, Gary A Kendrick, James W Udy, Angus J P Ferguson, Kieryn Kilminster, Peter Scanes, Len J McKenzie, Kathryn McMahon, Matthew P Adams, Jimena Samper-Villarreal, Catherine Collier, Mitchell Lyons, Peter J Mumby, Lynda Radke, Marjolijn J A Christianen, William C Dennison
Seagrass ecosystems are inherently dynamic, responding to environmental change across a range of scales. Habitat requirements of seagrass are well defined, but less is known about their ability to resist disturbance. Specific means of recovery after loss are particularly difficult to quantify. Here we assess the resistance and recovery capacity of 12 seagrass genera. We document four classic trajectories of degradation and recovery for seagrass ecosystems, illustrated with examples from around the world. Recovery can be rapid once conditions improve, but seagrass absence at landscape scales may persist for many decades, perpetuated by feedbacks and/or lack of seed or plant propagules to initiate recovery...
September 18, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28935298/physician-burnout-are-we-treating-the-symptoms-instead-of-the-disease
#8
John J Squiers, Kevin W Lobdell, James I Fann, J Michael DiMaio
Despite increasing recognition of physician burnout, its incidence has only increased in recent years, with nearly half of physicians suffering from symptoms of burnout in the most recent surveys. Unfortunately, most burnout research has focused on its profound prevalence rather than seeking to identify the root cause of the burnout epidemic. Health care organizations throughout the United States are implementing committees and support groups in an attempt to reduce burnout among their physicians, but these efforts are typically focused on increasing resilience and wellness among participants rather than combating problematic changes in how medicine is practiced by physicians in the current era...
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28935210/office-based-procedures-for-the-diagnosis-and-treatment-of-laryngeal-pathology
#9
REVIEW
David J Wellenstein, Henrieke W Schutte, Robert P Takes, Jimmie Honings, Henri A M Marres, James A Burns, Guido B van den Broek
INTRODUCTION: Since the development of distal chip endoscopes with a working channel, diagnostic and therapeutic possibilities in the outpatient clinic in the management of laryngeal pathology have increased. Which of these office-based procedures are currently available, and their clinical indications and possible advantages, remains unclear. MATERIAL AND METHODS: Review of literature on office-based procedures in laryngology and head and neck oncology. RESULTS: Flexible endoscopic biopsy (FEB), vocal cord injection, and laser surgery are well-established office-based procedures that can be performed under topical anesthesia...
September 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28935001/lack-of-effect-of-murine-astrovirus-infection-on-dextran-sulfate-induced-colitis-in-nlrp3-deficient-mice
#10
Susan R Compton, Carmen J Booth, James D Macy
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. MuAstV is found predominantly in the gastrointestinal tract of mice. Human and turkey astroviruses have been shown to disrupt tight junctions in the intestinal epithelium. The potential of MuAstV to alter research results was tested in a well-established dextran sodium sulfate (DSS)-induced colitis model in Nod-like receptor 3 (NLRP3)-deficient mice. This model offers a direct approach to determine whether MuAstV, as a component of the mouse microbiome, contributes to the issue of poor reproducibility in murine inflammatory bowel disease research...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28934096/children-s-lead-exposure-a-multimedia-modeling-analysis-to-guide-public-health-decision-making
#11
Valerie Zartarian, Jianping Xue, Rogelio Tornero-Velez, James Brown
BACKGROUND: Drinking water and other sources for lead are the subject of public health concerns around the Flint, Michigan, drinking water and East Chicago, Indiana, lead in soil crises. In 2015, the U.S. Environmental Protection Agency (EPA)'s National Drinking Water Advisory Council (NDWAC) recommended establishment of a "health-based, household action level" for lead in drinking water based on children's exposure. OBJECTIVES: The primary objective was to develop a coupled exposure-dose modeling approach that can be used to determine what drinking water lead concentrations keep children's blood lead levels (BLLs) below specified values, considering exposures from water, soil, dust, food, and air...
September 12, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28932287/the-effectiveness-of-ultrasound-guided-hydrodistension-and-physiotherapy-in-the-treatment-of-frozen-shoulder-adhesive-capsulitis-in-primary-care-a-single-centre-service-evaluation
#12
Michael Bryant, Andrew Gough, James Selfe, Jim Richards, Elizabeth Burgess
BACKGROUND: Evidence for optimal non-operative treatment of frozen shoulder is lacking. The present study aimed to evaluate a treatment strategy for stage II to III frozen shoulder provided by the current primary care musculoskeletal service. METHODS: General practioner referrals of shoulder pain to the musculoskeletal service diagnosed with stage II to III frozen shoulder and who opted for a treatment strategy of hydrodistension and guided physiotherapy exercise programme over a 12-month period were evaluated for 6 months...
October 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28932174/internet-based-computer-technology-on-radiotherapy
#13
REVIEW
James C L Chow
Recent rapid development of Internet-based computer technologies has made possible many novel applications in radiation dose delivery. However, translational speed of applying these new technologies in radiotherapy could hardly catch up due to the complex commissioning process and quality assurance protocol. Implementing novel Internet-based technology in radiotherapy requires corresponding design of algorithm and infrastructure of the application, set up of related clinical policies, purchase and development of software and hardware, computer programming and debugging, and national to international collaboration...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28931648/targeting-epithelial-mesenchymal-plasticity-in-cancer-clinical-and-preclinical-advances-in-therapy-and-monitoring
#14
REVIEW
Sugandha Bhatia, James Monkman, Alan Kie Leong Toh, Shivashankar H Nagaraj, Erik W Thompson
The concept of epithelial-mesenchymal plasticity (EMP), which describes the dynamic flux within the spectrum of phenotypic states that invasive carcinoma cells may reside, is being increasingly recognised for its role in cancer progression and therapy resistance. The myriad of events that are able to induce EMP, as well as the more recently characterised control loops, results in dynamic transitions of cancerous epithelial cells to more mesenchymal-like phenotypes through an epithelial-mesenchymal transition (EMT), as well as the reverse transition from mesenchymal phenotypes to an epithelial one...
September 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28930788/observation-of-dog-ear-regression-by-anatomical-location
#15
Thomas A Jennings, James C Keane, Rajat Varma, Stephanie B Walsh, Conway C Huang
BACKGROUND: When an excision is performed by a method other than elliptical excision, direct primary wound closure can result in standing cones or "dog-ears." In 2008, Lee and colleagues noted that dog-ears of <8 mm in height have a statistically greater tendency to resolve without further surgical correction than larger dog-ears. OBJECTIVE: To stratify dog-ears by anatomic location and inform on the need for correction at the time of surgery. MATERIALS AND METHODS: After tumor extirpation, patients were counseled that primary closure of the surgical wound would result in dog-ears at the wound apices...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28930762/competency-based-medical-education-in-the-internal-medicine-clerkship-a-report-from-the-alliance-for-academic-internal-medicine-undergraduate-medical-education-task-force
#16
Sara B Fazio, Cynthia H Ledford, Paul B Aronowitz, Shobhina G Chheda, John H Choe, Stephanie A Call, Scott D Gitlin, Marty Muntz, L James Nixon, Anne G Pereira, John W Ragsdale, Emily A Stewart, Karen E Hauer
As medical educators continue to redefine learning and assessment across the continuum, implementation of competency-based medical education in the undergraduate setting has become a focus of many medical schools. While standards of competency have been defined for the graduating student, there is no uniform approach for defining competency expectations for students during their core clerkship year. The authors describe the process by which an Alliance for Academic Internal Medicine task force developed a paradigm for competency-based assessment of students during their inpatient internal medicine (IM) clerkship...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930263/salicylate-poisoning-potential-of-topical-pain-relief-agents-from-age-old-remedies-to-engineered-smart-patches
#17
REVIEW
Ashleigh Anderson, Aaron McConville, Laura Fanthorpe, James Davis
The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse...
June 30, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929197/venous-invasion-by-hepatic-tumors-imaging-appearance-and-implications-for-management
#18
REVIEW
Scott M Thompson, Michael L Wells, James C Andrews, Eric C Ehman, Christine O Menias, Christopher L Hallemeier, Lewis R Roberts, Sudhakar K Venkatesh
Venous invasion by hepatic tumors most commonly occurs with hepatocellular carcinoma and is associated with worse patient prognosis. Imaging plays an important role in the diagnosis of tumor thrombus in the liver. Moreover, differentiating between bland and tumor thrombus in the liver has important diagnostic, staging, therapeutic, and prognostic implications and may require a multimodal imaging approach including ultrasound, computed tomography, and/or magnetic resonance imaging. Treatment of hepatic malignancies with associated tumor thrombus is dependent on tumor type, disease extent within the liver, liver hemodynamics, and underlying liver function...
September 19, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28929129/an-automated-home-cage-system-to-assess-learning-and-performance-of-a-skilled-motor-task-in-a-mouse-model-of-huntington-s-disease
#19
Cameron L Woodard, Federico BolaƱos, James D Boyd, Gergely Silasi, Timothy H Murphy, Lynn A Raymond
Behavioral testing is a critical step in assessing the validity of rodent models of neurodegenerative disease, as well as evaluating the efficacy of pharmacological interventions. In models of Huntington's disease (HD), a gradual progression of impairments is observed across ages, increasing the need for sensitive, high-throughput and longitudinal assessments. Recently, a number of automated systems have been developed to perform behavioral profiling of animals within their own home-cage, allowing for 24-h monitoring and minimizing experimenter interaction...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28928433/measuring-the-role-of-seagrasses-in-regulating-sediment-surface-elevation
#20
Maria Potouroglou, James C Bull, Ken W Krauss, Hilary A Kennedy, Marco Fusi, Daniele Daffonchio, Mwita M Mangora, Michael N Githaiga, Karen Diele, Mark Huxham
Seagrass meadows provide numerous ecosystem services and their rapid global loss may reduce human welfare as well as ecological integrity. In common with the other 'blue carbon' habitats (mangroves and tidal marshes) seagrasses are thought to provide coastal defence and encourage sediment stabilisation and surface elevation. A sophisticated understanding of sediment elevation dynamics in mangroves and tidal marshes has been gained by monitoring a wide range of different sites, located in varying hydrogeomorphological conditions over long periods...
September 20, 2017: Scientific Reports
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