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Cardiac disability

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https://www.readbyqxmd.com/read/28927176/permanent-work-disability-in-patients-%C3%A2-50-years-old-after-percutaneous-coronary-intervention-and-coronary-artery-bypass-grafting-the-crags-study
#1
Anna Lautamäki, Jarmo M Gunn, Kari Eino Juhani Airaksinen, Fausto Biancari, Olli A Kajander, Vesa Anttila, Jouni Heikkinen, Markku Eskola, Erkki Ilveskoski, Ari Mennander, Kari Korpilahti, Jan-Ola Wistbacka, Tuomas O Kiviniemi
Background: The aim of this study was to investigate the incidence of permanent working disability (PWD) in young patients after percutaneous or surgical coronary revascularization. Methods and Results: The study included 1035 consecutive patients ≤50 years old who underwent coronary revascularization [910 and 125 patients in percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) groups, respectively] between 2002 and 2012 at 4 Finnish hospitals...
April 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28923550/feelings-of-being-disabled-as-a-prognostic-factor-for-mortality-in-men-and-women-post-pci-up-to-12years
#2
Michael J Bergmann, Elisabeth M W J Utens, Tom A J de Jager, Sumant P Radhoe, Joost Daemen, Mattie J Lenzen, Ron T van Domburg, Karolijn Dulfer
BACKGROUND: It remains unclear whether feelings of being disabled are a relevant psychological factor that determines long term outcome after percutaneous coronary intervention (PCI). Therefore, we evaluated 'feelings of being disabled' as an independent risk factor for mortality 12years post-PCI. METHODS: The study population comprised a consecutive series of CAD patients (n=845) treated with PCI as part of the Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) registry...
September 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28915132/clinical-update-regarding-general-anesthesia-associated-neurotoxicity-in-infants-and-children
#3
M Ruth Graham
PURPOSE OF REVIEW: The U.S. Federal Drug Administration (FDA) recently released a warning stating that 'repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children's brains' (www.fda.gov/ucm582356.htm). The goal of this article is to review the most recent clinical studies which provide evidence that these concerns may be overstated for the majority of healthy young children who require surgery and anesthesia...
September 14, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28905509/de-novo-setd5-loss-of-function-variant-as-a-cause-for-intellectual-disability-in-a-10-year-old-boy-with-an-aberrant-blind-ending-bronchus
#4
Claire Green, Joshua Willoughby, Meena Balasubramanian
Although rare, 3p microdeletion cases have been well described in the clinical literature. The clinical phenotype includes; intellectual disability (ID), growth retardation, facial dysmorphism, and cardiac malformations. Advances in chromosome microarray (CMA) testing narrowed the 3p25 critical region to a 124 kb region, and recent Whole Exome Sequencing (WES) studies have suggested that the SETD5 gene contributes significantly to the 3p25 phenotype. Loss-of-Function (LoF) variants in SETD5 are now considered a likely cause of ID...
September 14, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28904070/antiarrhythmic-drugs-for-non-shockable-turned-shockable-out-of-hospital-cardiac-arrest-the-amiodarone-lidocaine-or-placebo-study-alps
#5
Peter J Kudenchuk, Brian G Leroux, Mohamud Daya, Thomas Rea, Christian Vaillancourt, Laurie J Morrison, Clifton W Callaway, James Christenson, Joseph P Ornato, James V Dunford, Lynn Wittwer, Myron L Weisfeldt, Tom P Aufderheide, Gary M Vilke, Ahamed H Idris, Ian G Stiell, M Riccardo Colella, Tami Kayea, Debra A Egan, Patrice Desvigne-Nickens, Pamela Gray, Randal Gray, Ron Straight, Paul Dorian
Background -Out-of-hospital cardiac arrest (OHCA) commonly presents with non-shockable rhythms (asystole and pulseless electrical activity (PEA)). Whether antiarrhythmic drugs are safe and effective when these evolve to shockable rhythms (ventricular fibrillation/pulseless ventricular tachycardia (VF/VT)) during resuscitation is not known. Methods -Adults with non-traumatic OHCA, vascular access and VF/VT anytime after ≥1 shock(s) were prospectively randomized, double-blind, to receive amiodarone, lidocaine or placebo by paramedics...
September 13, 2017: Circulation
https://www.readbyqxmd.com/read/28900318/normal-tissue-complications-following-hypofractionated-chest-wall-radiotherapy-in-breast-cancer-patients-and-their-correlation-with-patient-tumor-and-treatment-characteristics
#6
Mohsin Khan, Shahid A Siddiqui, Manoj K Gupta, Rajeev K Seam, Manish Gupta
INTRODUCTION: Normal tissue complications following chest wall radiotherapy (RT) are inevitable, and the long-term data on hypofractionation are still limited. To quantify the late effects of hypofractionated RT on cardiac, pulmonary, brachial plexus, and regional lymphatics and their correlation with patient, tumor, and treatment characteristics is the main objective of this study. MATERIALS AND METHODS: Two hundred and sixteen breast cancer patients following mastectomy were treated with hypofractionated schedules either 40 Gy in 15 fractions or 42...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28893208/trial-design-and-rationale-for-apollo-a-phase-3-placebo-controlled-study-of-patisiran-in-patients-with-hereditary-attr-amyloidosis-with-polyneuropathy
#7
David Adams, Ole B Suhr, Peter J Dyck, William J Litchy, Raina G Leahy, Jihong Chen, Jared Gollob, Teresa Coelho
BACKGROUND: Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality. METHODS: Here we describe the rationale and design of the Phase 3 APOLLO study, a randomized, double-blind, placebo-controlled, global study to evaluate the efficacy and safety of patisiran in patients with hATTR amyloidosis with polyneuropathy...
September 11, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28890042/guillain-barre-syndrome-in-the-elderly-experience-from-a-tertiary-care-hospital-in-india
#8
M Nagappa, W Rahul, S Sinha, P S Bindu, P S Mathuranath, S Rao, S Periyavan, G S Umamaheshwara Rao, A B Taly
Age influences incidence and prognosis of Guillain Barre Syndrome (GBS), common cause of ascending areflexic quadriparesis. Dedicated studies on elderly GBS are infrequent. This study aimed to describe clinical features and outcome at hospital-discharge in patients aged≥60years with GBS. Medical records of 70 elderly GBS over 15years were analysed. Mean symptom-duration was 5.78±4.5days and onset-to-peak 5.14±4.4days. Antecedent events preceded GBS by 8.07±9.9days and included: fever (n=19), respiratory infection (n=6), and gastroenteritis (n=5)...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28886392/how-do-you-define-body-image-exploring-conceptual-gaps-in-understandings-of-body-image-at-an-exercise-facility
#9
K Alysse Bailey, Kimberley L Gammage, Cathy van Ingen
The definition of body image has evolved within research; however, less is known about the layperson's understanding of the construct. This study explored how members and student trainees of an exercise facility (designed for older adults, people with physical disability, and those with cardiac complications) defined body image. Nineteen participants completed a one-on-one interview, and seven of those participants took part in six additional focus group meetings. The following main themes were found: stereotypical assumptions about body image (e...
September 5, 2017: Body Image
https://www.readbyqxmd.com/read/28878239/mutation-e87q-of-the-%C3%AE-1-subunit-impairs-the-maturation-of-the-cardiac-voltage-dependent-sodium-channel
#10
Debora Baroni, Cristiana Picco, Oscar Moran
Voltage-dependent sodium channels are responsible of the rising phase of the action potential in excitable cells. These membrane integral proteins are composed by a pore-forming α-subunit, and one or more auxiliary β subunits. Mutation E87Q of the β1 subunit is correlated with Brugada syndrome, a genetic disease characterised by ventricular fibrillation, right precordial ST segment elevation on ECG and sudden cardiac death. Heterologous expression of E87Q-β1 subunit in CHO cells determines a reduced sodium channel functional expression...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874292/malignant-cardiac-phenotypic-expression-of-danon-disease-lamp2-cardiomyopathy
#11
Fatima Samad, Renuka Jain, M Fuad Jan, Nasir Z Sulemanjee, Puneet Menaria, Lindsey Kalvin, Michelle Bush, Arshad Jahangir, Bijoy K Khandheria, A Jamil Tajik
INTRODUCTION: Danon disease is an X-linked lysosomal condition that causes a deficiency of lysosome-associated membrane protein 2 (LAMP2) gene. It is characterized clinically by a triad of skeletal myopathy, cardiomyopathy, and intellectual disability. METHODS: We examined clinical, echocardiographic, and genetic data on 5 patients with Danon disease, highlighting their clinical course and outcomes. RESULTS: All patients presented phenotypically with hypertrophic cardiomyopathy and later developed systolic dysfunction...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28872494/the-genetics-of-congenital-heart-disease%C3%A2-understanding-and-improving-long-term-outcomes-in-congenital-heart-disease-a-review-for-the-general-cardiologist-and-primary-care-physician
#12
M Abigail Simmons, Martina Brueckner
PURPOSE OF REVIEW: This review has two purposes: to provide an updated review of the genetic causes of congenital heart disease (CHD) and the clinical implications of these genetic mutations, and to provide a clinical algorithm for clinicians considering a genetics evaluation of a CHD patient. RECENT FINDINGS: A large portion of congenital heart disease is thought to have a significant genetic contribution, and at this time a genetic cause can be identified in approximately 35% of patients...
October 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28870222/general-anesthetics-protects-against-cardiac-arrest-induced-brain-injury-by-inhibiting-calcium-wave-propagation-in-zebrafish
#13
Dao-Jie Xu, Bin Wang, Xuan Zhao, Yi Zheng, Jiu-Lin Du, Ying-Wei Wang
Cardiac arrest is a leading cause of death and disability worldwide. Although many victims are initially resuscitated, they often suffer from serious brain injury, even leading to a "persistent vegetative state". Therefore, it is need to explore therapies which restore and protect brain function after cardiac arrest. In the present study, using Tg (HuC:GCaMP5) zebrafish as a model, we found the zebrafish brain generated a burst of Ca(2+) wave after cardiac arrest by in vivo time-lapse confocal imaging. The Ca(2+) wave was firstly initiated at hindbrain and then sequentially propagated to midbrain and telencephalon, the neuron displayed Ca(2+) overload after Ca(2+) wave propagation...
September 4, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28869405/a-telehealth-intervention-to-promote-healthy-lifestyles-after-stroke-the-stroke-coach-protocol
#14
Brodie M Sakakibara, Scott A Lear, Susan I Barr, Oscar Benavente, Charlie H Goldsmith, Noah D Silverberg, Jennifer Yao, Janice J Eng
Rationale Recurrent stroke is prevalent and associated with high mortality rates, disability, and social and economic costs. Adequate management of risk factors may reduce recurrent stroke; however, many stroke survivors have poor control of risk factors. We have developed a theoretically sound and evidence-based lifestyle modification program called the Stroke Coach, a telephone-based self-management program to improve control of risk factors. Hypothesis Individuals who participate in Stroke Coach will achieve more lifestyle improvements than individuals in an attention controlled Memory Training Program...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28867011/tavr-with-mechanically-expandable-prostheses-is-balloon-aortic-valvuloplasty-really-necessary
#15
Giuseppe Tarantini, Luca Nai Fovino, Paola Tellaroli, Paola Purita, Giulia Masiero, Massimo Napodano, Chiara Fraccaro, Gino Gerosa, Sabino Iliceto
BACKGROUND: The fully retrievable and repositionable Lotus Valve System uses a unique mechanical expansion mechanism. Balloon aortic valvuloplasty (BAV) is recommended before valve deployment. There are no studies focusing on feasibility and efficacy of Lotus Valve implantation without previous BAV. METHODS AND RESULTS: Thirty consecutive patients (63.3% female; mean age, 80±6.2years) underwent transcatheter aortic valve replacement (TAVR) with the Lotus Valve without preparatory BAV...
November 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28861407/alterations-in-cerebral-blood-flow-after-resuscitation-from-cardiac-arrest
#16
REVIEW
Bistra Iordanova, Lingjue Li, Robert S B Clark, Mioara D Manole
Greater than 50% of patients successfully resuscitated from cardiac arrest have evidence of neurological disability. Numerous studies in children and adults, as well as in animal models have demonstrated that cerebral blood flow (CBF) is impaired after cardiac arrest. Stages of cerebral perfusion post-resuscitation include early hyperemia, followed by hypoperfusion, and finally either resolution of normal blood flow or protracted hyperemia. At the level of the microcirculation the blood flow is heterogeneous, with areas of no flow, low flow, and increased flow...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28859792/how-medicine-has-changed-the-end-of-life-for-patients-with-cardiovascular-disease
#17
REVIEW
Haider J Warraich, Adrian F Hernandez, Larry A Allen
Advances in medicine have changed how patients experience the end of life. With longer life spans, there has also been an increase in years lived with disability. The clustering of illnesses in the last years of life is particularly pronounced in patients with cardiovascular disease. At the end of life, patients with cardiovascular disease are more symptomatic, less likely to die at home, and less likely to receive high-quality palliative care. Social determinants have created widening disparities in end-of-life care...
September 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28856140/new-insights-about-the-putative-role-of-myokines-in-the-context-of-cardiac-rehabilitation-and-secondary-cardiovascular-prevention
#18
REVIEW
Domenico Di Raimondo, Giuseppe Miceli, Gaia Musiari, Antonino Tuttolomondo, Antonio Pinto
Exercise training prevents the onset and the development of many chronic diseases, acting as an effective tool both for primary and for secondary prevention. Various mechanisms that may be the effectors of these beneficial effects have been proposed during the past decades: some of these are well recognized, others less. Muscular myokines, released during and after muscular contraction, have been proposed as key mediators of the systemic effects of the exercise. Nevertheless the availability of an impressive amount of evidence regarding the systemic effects of muscle-derived factors, few studies have examined key issues: (I) if skeletal muscle cells themselves are the main source of cytokine during exercise; (II) if the release of myokines into the systemic circulation reach an adequate concentration to provide significant effects in tissues far from skeletal muscle; (III) what may be the role carried out by muscular cytokine regarding the well-known benefits induced by regular exercise, first of all the anti-inflammatory effect of exercise...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28836570/thirty-day-postoperative-complications-following-primary-total-knee-arthroplasty-a-retrospective-study-of-incidence-and-risk-factors-at-a-single-center-in-china
#19
Bin Feng, Jin Lin, Jin Jin, Wen-Wei Qian, Wei Wang, Xi-Sheng Weng
BACKGROUND: Total knee arthroplasty (TKA) may be associated with serious complications that adversely affect outcomes and increase the likelihood of disability. However, few studies with sufficient sample size have reported postoperative complications following TKA among Chinese patients. This study aimed to evaluate complications of TKA within 30 postoperative days and to identify the related risk factors. METHODS: A retrospective complication-based analysis of TKA using the arthroplasty registry between 2008 and 2013 was performed by summarizing complications of TKA within 30 postoperative days...
August 16, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28827077/high-potential-defense-mechanisms-of-neocortex-in-a-rat-model-of-transient-asphyxia-induced-cardiac-arrest
#20
Gerburg Keilhoff, Torben Esser, Maximilian Titze, Uwe Ebmeyer, Lorenz Schild
Cardiac arrest (CA) is a common cause of disability and mortality and thus an important risk for human health. Circulatory failure has dramatic consequences for the brain as one of the most oxygen-consuming organs. Hippocampus, striatum and neocortex rate among the most vulnerable brain regions. The neocortex is less sensitive to hypoxia/reperfusion in comparison with the hippocampal CA1 region. That implicates the existence of efficient defense mechanisms in the neocortex against hypoxia/reperfusion injury, which we analyzed in a well-established CA rat model...
August 18, 2017: Brain Research
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