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https://www.readbyqxmd.com/read/29050352/ras-testing-and-cetuximab-treatment-for-metastatic-colorectal-cancer-a-cost-effectiveness-analysis-in-a-setting-with-limited-health-resources
#1
Bin Wu, Yuan Yao, Ke Zhang, Xuezhen Ma
PURPOSE: To test the cost-effectiveness of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment in patients with metastatic colorectal cancer (mCRC) from a Chinese medical insurance perspective. RESULTS: Baseline analysis showed that the addition of cetuximab increased quality-adjusted life-years (QALYs) by 0.63, an increase of $17,086 relative to FOLFIRI chemotherapy, resulting in an incremental cost-effectiveness ratio (ICER) of $27,145/QALY...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049955/the-engine-and-the-reaper-industrialization-and-mortality-in-late-nineteenth-century-japan
#2
John P Tang
Economic development improves long-run health outcomes through access to medical treatment, sanitation, and higher income. Short run impacts, however, may be ambiguous given disease exposure from market integration. Using a panel dataset of Japanese vital statistics and multiple estimation methods, I find that railroad network expansion is associated with a six percent increase in gross mortality rates among newly integrated regions. Communicable diseases accounted for most of the rail-associated mortality, which indicate railways behaved as transmission vectors...
September 11, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29049920/factors-associated-with-vision-related-quality-of-life-among-the-adult-population-living-in-nagorno-karabagh
#3
T Harutyunyan, A Giloyan, V Petrosyan
OBJECTIVES: Visual impairment and blindness are major public health problems causing significant suffering, disability, loss of productivity, and diminishing quality of life for millions of people. This study explored the factors associated with the overall vision-related quality of life (VRQoL) and its different domains in the adult population of Nagorno Karabakh and assessed the independent contribution of specific eye diseases to VRQoL. STUDY DESIGN: A cross-sectional study...
October 16, 2017: Public Health
https://www.readbyqxmd.com/read/29048965/the-effectiveness-of-hiv-prevention-interventions-in-socioeconomically-disadvantaged-ethnic-minority-women-a-systematic-review-and-meta-analysis
#4
Isabel Ruiz-Perez, Matthew Murphy, Guadalupe Pastor-Moreno, Antonio Rojas-García, Miguel Rodríguez-Barranco
BACKGROUND: Surveys in the United States and Europe have shown a plateau of new HIV cases, with certain regions and populations disproportionately affected by the disease. Ethnic minority women and socioeconomically disadvantaged groups are disproportionately affected by HIV. Previous reviews have focused on prevention interventions targeting ethnic minority men who have sex with men, have not accounted for socioeconomic status, or have included only interventions carried out in clinical settings...
October 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048726/trends-in-inequalities-in-child-stunting-in-south-asia
#5
Aditi Krishna, Iván Mejía-Guevara, Mark McGovern, Victor Aguayo, S V Subramanian
We analysed socio-economic inequalities in stunting in South Asia and investigated disparities associated with factors at the individual, caregiver, and household levels (poor dietary diversity, low maternal education, and household poverty). We used time-series analysis of data from 55,459 children ages 6-23 months from Demographic and Health Surveys in Bangladesh, India, Nepal, and Pakistan (1991-2014). Logistic regression models, adjusted for age, sex, birth order, and place of residency, examined associations between stunting and multiple types of socio-economic disadvantage...
October 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29048472/trajectories-of-long-term-care-in-28-eu-countries-evidence-from-a-time-series-analysis
#6
Maria Michela Gianino, Jacopo Lenzi, Maria Martorana, Marco Bonaudo, Maria Pia Fantini, Roberta Siliquini, Walter Ricciardi, Gianfranco Damiani
Background: This study aims to confirm whether an increase in the number of elderly people and a worsening in the auto-evaluation of the general health state and in the limitation of daily activities result in increases in the offered services (beds in residential LTC facilities), in the social and healthcare expenditure and, consequently, in the percentage of LTC users. Methods: This study used a pooled, cross-sectional, time series design focusing on 28 European countries from 2004 to 2015...
October 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29048386/leveraging-the-domain-of-work-to-improve-migrant-health
#7
Michael A Flynn, Kolitha Wickramage
Work is a principal driver of current international migration, a primary social determinant of health, and a fundamental point of articulation between migrants and their host society. Efforts by international organizations to promote migrant health have traditionally focused on infectious diseases and access to healthcare, while international labor organizations have largely focused on issues of occupational health. The underutilization of the domain of work in addressing the health of migrants is truly a missed opportunity for influencing worker well-being and reducing societal economic burden...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29047413/itactic-implementing-treatment-algorithms-for-the-correction-of-trauma-induced-coagulopathy-study-protocol-for-a-multicentre-randomised-controlled-trial
#8
Kjersti Baksaas-Aasen, Lewis Gall, Simon Eaglestone, Claire Rourke, Nicole P Juffermans, J Carel Goslings, Paal Aksel Naess, Susan van Dieren, Sisse Rye Ostrowski, Jakob Stensballe, Marc Maegele, Simon J Stanworth, Christine Gaarder, Karim Brohi, Per I Johansson
BACKGROUND: Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown to induce a clotting dysfunction within minutes, and this early trauma-induced coagulopathy (TIC) may exacerbate bleeding and is associated with higher mortality and morbidity. In spite of improved resuscitation strategies over the last decade, current transfusion therapy still fails to correct TIC during ongoing haemorrhage and evidence for the optimal management of bleeding trauma patients is lacking...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29047389/investigating-local-policy-drivers-for-alcohol-harm-prevention-a-comparative-case-study-of-two-local-authorities-in-england
#9
John D Mooney, John Holmes, Lucy Gavens, Frank de Vocht, Matt Hickman, Karen Lock, Alan Brennan
BACKGROUND: The considerable challenges associated with implementing national level alcohol policies have encouraged a renewed focus on the prospects for local-level policies in the UK and elsewhere. We adopted a case study approach to identify the major characteristics and drivers of differences in the patterns of local alcohol policies and services in two contrasting local authority (LA) areas in England. METHODS: Data were collected via thirteen semi-structured interviews with key informants (including public health, licensing and trading standards) and documentary analysis, including harm reduction strategies and statements of licensing policy...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29047362/the-greenh-city-interventional-research-protocol-on-health-in-all-policies
#10
Marion Porcherie, Zoé Vaillant, Emmannuelle Faure, Stéphane Rican, Jean Simos, Nicola Luca Cantoreggi, Zoé Heritage, Anne Roue Le Gall, Linda Cambon, Thierno Amadou Diallo, Eva Vidales, Jeanine Pommier
BACKGROUND: This paper presents the research protocol of the GoveRnance for Equity, EnviroNment and Health in the City (GREENH-City) project funded by the National Institute for Cancer (Subvention N°2017-003-INCA). In France, health inequities have tended to increase since the late 1980s. Numerous studies show the influence of social, economic, geographic and political determinants on health inequities across the life course. Exposure to environmental factors is uneven across the population and may impact on health and health inequities...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29047336/a-qualitative-exploration-of-work-related-head-injury-vulnerability-at-the-intersection-of-workers-decision-making-and-organizational-values
#11
P Kontos, A Grigorovich, B Nowrouzi, B Sharma, J Lewko, T Mollayeva, A Colantonio
BACKGROUND: Work-related head injury is a critical public health issue due to its rising prevalence; the association with profound disruption of workers' lives; and significant economic burdens in terms of medical costs and lost wages. Efforts to understand and prevent these types of injuries have largely been dominated by epidemiological research and safety science, which has focused on identifying risk at the level of the individual worker, population group, or organizational sector...
October 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29047317/varicella-and-herpes-zoster-vaccine-development-lessons-learned
#12
Charlotte Warren-Gash, Harriet Forbes, Judith Breuer
Introduction Before vaccination, varicella zoster virus (VZV), which is endemic worldwide, led to almost universal infection. This neurotropic virus persists lifelong by establishing latency in sensory ganglia, where its reactivation is controlled by VZV-specific T-cell immunity. Lifetime risk of VZV reactivation (zoster) is around 30%. Vaccine development was galvanised by the economic and societal burden of VZV, including debilitating zoster complications that largely affect older individuals. Areas covered We describe the story of development, licensing and implementation of live attenuated vaccines against varicella and zoster...
October 19, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29047174/pediatric-allergy-and-immunology-in-china
#13
REVIEW
Gary Wk Wong, Jing Li, Yi-Xiao Bao, Jiu-Yao Wang, Ting Fan Leung, Luan-Luan Li, Jie Shao, Xin-Yuan Huang, En-Mei Liu, Shen Kun-Ling, Chen Yu-Zhi
Over the past thirty years, China has enjoyed rapid economic development along with urbanization at a massive scale that the world has not experienced before. Such development has also been associated with a rapid rise in the prevalence of allergic disorders. Because of the large childhood population in the country, the burden of childhood allergic disorders has become one of the major challenges in the health care system. Among the Chinese centers participating in the International Study of Asthma and Allergies in Childhood clearly, the data showed a continuing rise in the prevalence of asthma, allergic rhinitis and atopic eczema...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29047072/involving-members-of-the-public-in-health-economics-research-insights-from-selecting-health-states-for-valuation-to-estimate-quality-adjusted-life-year-qaly-weights
#14
Elizabeth Goodwin, Kate Boddy, Lynn Tatnell, Annie Hawton
Over recent years, public involvement in health research has expanded considerably. However, public involvement in designing and conducting health economics research is seldom reported. Here we describe the development, delivery and assessment of an approach for involving people in a clearly defined piece of health economics research: selecting health states for valuation in estimating quality-adjusted life-years (QALYs). This involvement formed part of a study to develop a condition-specific preference-based measure of health-related quality of life, the Multiple Sclerosis Impact Scale (MSIS-8D), and the work reported here relates to the identification of plausible, or realistic, health states for valuation...
October 19, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29047020/rotavirus-epidemiology-and-vaccine-demand-considering-bangladesh-chapter-through-the-book-of-global-disease-burden
#15
REVIEW
Abdullah Mahmud-Al-Rafat, Abdul Muktadir, Hasneen Muktadir, Mahbubul Karim, Arpan Maheshwari, Mohammad Mainul Ahasan
BACKGROUND: Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infection. The situation leads to severe economic loss and constitutes a major public health problem. METHODS: We searched electronic databases including PubMed and Google scholar using the following words: "features of rotavirus," "epidemiology of rotavirus," "rotavirus serotypes," "rotavirus in Bangladesh," "disease burden of rotavirus," "rotavirus vaccine," "low efficacy of rotavirus vaccine," "inactivated rotavirus vaccine"...
October 19, 2017: Infection
https://www.readbyqxmd.com/read/29046785/educational-inequalities-in-premature-mortality-by-region-in-the-belgian-population-in-the-2000s
#16
Françoise Renard, Brecht Devleesschauwer, Sylvie Gadeyne, Jean Tafforeau, Patrick Deboosere
BACKGROUND: In Belgium, socio-economic inequalities in mortality have long been described at country-level. As Belgium is a federal state with many responsibilities in health policies being transferred to the regional levels, regional breakdown of health indicators is becoming increasingly relevant for policy-makers, as a tool for planning and evaluation. We analyzed the educational disparities by region for all-cause and cause-specific premature mortality in the Belgian population. METHODS: Residents with Belgian nationality at birth registered in the census 2001 aged 25-64 were included, and followed up for 10 years though a linkage with the cause-of-death database...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29046570/general-ecological-models-for-human-subsistence-health-and-poverty
#17
Calistus N Ngonghala, Giulio A De Leo, Mercedes M Pascual, Donald C Keenan, Andrew P Dobson, Matthew H Bonds
The world's rural poor rely heavily on their immediate natural environment for subsistence and suffer high rates of morbidity and mortality from infectious diseases. We present a general framework for modelling subsistence and health of the rural poor by coupling simple dynamic models of population ecology with those for economic growth. The models show that feedbacks between the biological and economic systems can lead to a state of persistent poverty. Analyses of a wide range of specific systems under alternative assumptions show the existence of three possible regimes corresponding to a globally stable development equilibrium, a globally stable poverty equilibrium and bistability...
August 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/29046149/schizophrenia-and-nicotine-dependence-what-psychopharmacological-treatment-options-are-available-for-the-duo-perturbationes
#18
Yoong Mei Theng, Suzaily Wahab, Noor Alaudin Wahab, Hatta Sidi, Srijit Das
Nicotine dependence has progressively become a foremost community health interest in the both developed and developing nations due to the economic burden and health-related problem. Smoking was significantly higher among patients with schizophrenia in comparison to the general population. Nicotine dependence is not only associated with public stress, but among patients with schizophrenia, smoking brings major challenges to the management. Nicotine may diminish the therapeutic efficacy of the bioavailability of the psychopharmacological agents in-vivo...
October 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29044374/human-and-livestock-trematode-infections-in-a-mobile-pastoralist-setting-at-lake-chad-added-value-of-a-one-health-approach-beyond-zoonotic-diseases-research
#19
Helena Greter, Annour A Batil, Bongo N Ngandolo, Idriss O Alfaroukh, Doumagoum D Moto, Jan Hattendorf, Jürg Utzinger, Jakob Zinsstag
Background: At Lake Chad in Central Africa, mobile pastoralists face economic losses due to livestock trematodiases. Fasciola gigantica and Schistosoma bovis-trematodes that affect livestock-share transmission ecology traits with Schistosoma haematobium and S. mansoni that cause human schistosomiasis. This project aimed at assessing treatment strategies and elucidating the predictive potential of human and livestock trematode infections. Methods: Schistosomiasis and fascioliasis were investigated concurrently in humans and cattle by repeated cross-sectional surveys...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29044372/should-we-be-treating-animal-schistosomiasis-in-africa-the-need-for-a-one-health-economic-evaluation-of-schistosomiasis-control-in-people-and-their-livestock
#20
Charlotte M Gower, Louise Vince, Joanne P Webster
A One Health economic perspective allows informed decisions to be made regarding control priorities and/or implementation strategies for infectious diseases. Schistosomiasis is a major and highly resilient disease of both humans and livestock. The zoonotic component of transmission in sub-Saharan Africa appears to be more significant than previously assumed, and may thereby affect the recently revised WHO vision to eliminate schistosomiasis as a public health problem by 2025. Moreover, animal schistosomiasis is likely to be a significant cost to affected communities due to its direct and indirect impact on livelihoods...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
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