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Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girardi
Genetic factors have been reported to contribute to the liability of suicide. We aimed to investigate functional polymorphisms in eight genes (serotonin transporter, SLC6A4; receptors, 5HTR1A, 1B, 5HTR2A; Tryptophan Hydroxylase, TPH1, TPH2; Monoamine Oxidase, MAOA and G Protein Subunit Beta 3, GNB3) to investigate their predictive value for suicide. The possible confounding effects of gender and phenotypic patients dissection were also valued. A sample of 111 consecutive psychiatric inpatients was recruited and assessed using specific psychometric instruments...
July 14, 2017: Neuroscience Letters
S Ohlerth, S Senn, U Geissbühler, P Kircher, M Flückiger
Osteochondrosis (OC) is common in large-breed dogs. According to the breeding guidelines of the Swiss kennel clubs, the shoulder joints are included in the radiographic screening for joint diseases in the Greater Swiss Mountain dog (GSMD) and the Border Collie (BC) since 1993 and 2003, respectively. The aim of this study was to estimate the overall prevalence of humeral head OC in these 2 breeds in Switzerland based on the data of the Swiss National Dysplasia Committees. All radiographs were re-evaluated to assess single radiographic changes...
November 2016: Schweizer Archiv Für Tierheilkunde
Maurizio Pompili, Marco Innamorati, Mariantonietta Milelli, Michele Battuello, Denise Erbuto, David Lester, Xenia Gonda, Zoltan Rihmer, Mario Amore, Paolo Girardi
BACKGROUND: Temperaments in completed suicides have never been assessed whereas there is substantial research on temperaments in attempted suicides and psychiatric patients. METHODS: The significant others of 18 completed suicides participated in this study in order to provide an assessment of temperaments, hopelessness, depression and the suicide risk of their loved ones. The data were compared with data from 244 psychiatric patients of whom 83 had attempted suicide in the previous month...
February 2016: Comprehensive Psychiatry
Christopher F Sharpley, Vicki Bitsika, David R H Christie, Myra S Hunter
Up to a quarter of all prostate cancer (PCa) patients suffer from clinically significant depression but treatments are inconsistent and short-lived in their efficacy. One possible reason could be that "male depression" is not adequately diagnosed by the criteria for major depressive disorder (MDD) used in many clinical settings. In response to this limitation, the Gotland Scale of Male Depression (GSMD) was developed to identify the extra symptoms of MDD in men. Although the factor structure of the GSMD has been reported in non-PCa samples, it has not been determined for this group of men...
August 13, 2015: American Journal of Men's Health
Maurizio Pompili, Marco Innamorati, Xenia Gonda, Denise Erbuto, Alberto Forte, Federica Ricci, David Lester, Hagop S Akiskal, Gustavo H Vázquez, Zoltan Rihmer, Mario Amore, Paolo Girardi
BACKGROUND: Mood disorders (MD) are disabling conditions throughout the world associated with significant psychosocial impairment. Affective temperaments, as well as hopelessness, may play a significant role in the pathophysiology of MD. The present study was designed to characterize patients with MD for their prevalent affective temperament and level of hopelessness. METHODS: Five hundred fifty-nine (253 men and 306 women) consecutive adult inpatients were assessed using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), the Gotland Scale for Male Depression (GSMD), the Beck Hopelessness Scale (BHS) and the Mini International Neuropsychiatric Interview (MINI)...
September 2014: Journal of Affective Disorders
Gloria Angeletti, Maurizio Pompili, Marco Innamorati, Chiara Santucci, Valeria Savoja, Mark Goldblatt, Paolo Girardi
Objectives and Methods. This was an observational study of the efficacy of short-term psychodynamic psychotherapy (STPP) in a sample of 35 (30 women and 5 men) patients with moderate-to-severe "male depression" (Gotland Scale for Male Depression (GSMD) ≥ 13) comorbid with unipolar mood disorder (dysthymia and major depression) or anxiety disorder. Outcome measures were GSMD and BHS (Beck Hopelessness Scale) score changes from baseline. Results. Patients had a strong response to STPP on the GSMD (estimated mean score change (± SE) = -9...
2013: Depression Research and Treatment
Maurizio Pompili, Marco Innamorati, Zoltan Rihmer, Xenia Gonda, Gianluca Serafini, Hagop Akiskal, Mario Amore, Cinzia Niolu, Leo Sher, Roberto Tatarelli, Giulio Perugi, Paolo Girardi
BACKGROUND: Suicidal behavior is one of the most alarming signs not only in psychiatry, and current major depressive episode is the most frequent medical condition among suicide victims and attempters. The aim of the study was to investigate the relationship between the individual pattern of affective temperaments, non-typical symptoms of depression as measured with the Gotland Scale for Male Depression (GSMD), hopelessness and suicidal behavior in major mood disorder patients. METHODS: Participants were 346 adult inpatients (151 men and 195 women) with major mood disorders consecutively admitted to the Department of Psychiatry of the Sant'Andrea University Hospital in Rome, Italy...
February 2012: Journal of Affective Disorders
Kari J Ekenstedt, Edward E Patterson, Katie M Minor, James R Mickelson
BACKGROUND: Idiopathic epilepsy (IE) is a naturally occurring and significant seizure disorder affecting all dog breeds. Because dog breeds are genetically isolated populations, it is possible that IE is attributable to common founders and is genetically homogenous within breeds. In humans, a number of mutations, the majority of which are genes encoding ion channels, neurotransmitters, or their regulatory subunits, have been discovered to cause rare, specific types of IE. It was hypothesized that there are simple genetic bases for IE in some purebred dog breeds, specifically in Vizslas, English Springer Spaniels (ESS), Greater Swiss Mountain Dogs (GSMD), and Beagles, and that the gene(s) responsible may, in some cases, be the same as those already discovered in humans...
April 25, 2011: BMC Genetics
Marco Innamorati, Maurizio Pompili, Xenia Gonda, Mario Amore, Gianluca Serafini, Cinzia Niolu, David Lester, Wolfgang Rutz, Zoltan Rihmer, Paolo Girardi
BACKGROUND: Rutz has postulated a "male depressive syndrome" measured by the Gotland Scale of Male Depression (GSMD). The aim of the study was to assess the psychometric properties of the GSMD in a sample of male and female psychiatric inpatients. METHODS: The sample was composed of 326 Italian inpatients who completed the GSMD and the Beck Hopelessness Scale (BHS). RESULTS: Our results indicated that all the items of the GSMD, except item #13, were highly interrelated, and that the first 12 items of the GSMD may be considered a homogeneous measure of depression...
July 2011: Journal of Affective Disorders
S Egawa, M Ohori, S Soh, T Kawakami, H Udagawa, T Uchida, E Yokoyama, K Koshiba
Diagnostic utility of serum markers and their relative values to prostatic volume were evaluated using Receiver Operator Characteristics Analysis (ROC analysis) in 173 patients who underwent ultrasound guided biopsy of the prostate gland. Seventy cases (40.5%) of prostate cancer were detected. As a whole, prostate specific antigen density (PSAD) and prostate specific antigen (PSA) were more useful than gammaseminoprotein density (GSMD), gammaseminoprotein (GSM) and prostatic acid phosphatase in diagnosing cancer judged by the area under the ROC curve denoting a test's diagnostic accuracy (p < 0...
October 1994: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
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