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Neuromuscular medicine

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https://www.readbyqxmd.com/read/27846348/pharmacological-treatment-other-than-corticosteroids-intravenous-immunoglobulin-and-plasma-exchange-for-guillain-barr%C3%A3-syndrome
#1
REVIEW
Jane Pritchard, Richard Ac Hughes, Robert Dm Hadden, Ruth Brassington
BACKGROUND: Plasma exchange and intravenous immunoglobulin, but not corticosteroids, are beneficial in Guillain-Barré syndrome (GBS). The efficacy of other pharmacological agents is unknown. This review was first published in 2011 and updated in 2013 and 2016. OBJECTIVES: To assess the effects of pharmacological agents other than plasma exchange, intravenous immunoglobulin and corticosteroids for GBS. SEARCH METHODS: On 18 January 2016, we searched the Cochrane Neuromuscular Specialised Register, Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for treatments for GBS...
November 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27834612/the-effectiveness-of-neuromuscular-electrical-stimulation-in-improving-voluntary-activation-of-the-quadriceps-a-critically-appraised-topic
#2
Cody B Bremner, William R Holcomb, Christopher D Brown, Melanie E Perreault
: Clinical Scenario: Orthopedic knee conditions are regularly treated in sports medicine clinics. Rehabilitation protocols for these conditions are often designed to address the associated quadriceps strength deficits. Despite these efforts, patients with orthopedic knee conditions often fail to completely regain their quadriceps strength. Disinhibitory modalities have recently been suggested as a clinical tool that can be used to counteract the negative effects of arthrogenic muscle inhibition (AMI), which is believed to limit the effectiveness of therapeutic exercise...
November 11, 2016: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/27790273/clinical-practice-guideline-of-acute-respiratory-distress-syndrome
#3
REVIEW
Young-Jae Cho, Jae Young Moon, Ein-Soon Shin, Je Hyeong Kim, Hoon Jung, So Young Park, Ho Cheol Kim, Yun Su Sim, Chin Kook Rhee, Jaemin Lim, Seok Jeong Lee, Won-Yeon Lee, Hyun Jeong Lee, Sang Hyun Kwak, Eun Kyeong Kang, Kyung Soo Chung, Won-Il Choi
There is no well-stated practical guideline for mechanically ventilated patients with or without acute respiratory distress syndrome (ARDS). We generate strong (1) and weak (2) grade of recommendations based on high (A), moderate (B) and low (C) grade in the quality of evidence. In patients with ARDS, we recommend low tidal volume ventilation (1A) and prone position if it is not contraindicated (1B) to reduce their mortality. However, we did not support high-frequency oscillatory ventilation (1B) and inhaled nitric oxide (1A) as a standard treatment...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27786371/proper-performance-of-autonomic-function-testing
#4
(no author information available yet)
INTRODUCTION: The aim of this position statement is to provide a recommendation from experts at the AANEM on the proper performance of autonomic testing. METHOD: The AANEM Professional Practice Committee and selected AANEM members reached a consensus based on expert opinion on the training required to perform autonomic testing and the appropriate performance of such tests. RESULTS: Individuals without sufficient medical education in autonomic disorders are unqualified to interpret the data generated or to coordinate the findings with other clinical information in order to reach a clinical diagnosis...
October 27, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27755068/clinical-practice-guidelines-for-sustained-neuromuscular-blockade-in-the-adult-critically-ill-patient
#5
Michael J Murray, Heidi DeBlock, Brian Erstad, Anthony Gray, Judi Jacobi, Che Jordan, William McGee, Claire McManus, Maureen Meade, Sean Nix, Andrew Patterson, M Karen Sands, Richard Pino, Ann Tescher, Richard Arbour, Bram Rochwerg, Catherine Friederich Murray, Sangeeta Mehta
OBJECTIVE: To update the 2002 version of "Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient." DESIGN: A Task Force comprising 17 members of the Society of Critical Medicine with particular expertise in the use of neuromuscular-blocking agents; a Grading of Recommendations Assessment, Development, and Evaluation expert; and a medical writer met via teleconference and three face-to-face meetings and communicated via e-mail to examine the evidence and develop these practice guidelines...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27712572/old-new-and-hidden-causes-of-perioperative-hypersensitivity
#6
Lene H Garvey
Perioperative hypersensitivity reactions are rare, often life-threatening events, and subsequent investigations to identify the culprit are important to avoid re-exposure. All exposures in the perioperative setting may potentially be the cause of a hypersensitivity reaction, but drugs administered intravenously such as neuromuscular blocking agents (NMBA), induction agents and antibiotics have traditionally been reported to be implicated most commonly. It has recently become apparent that there are geographical differences in sensitization patterns related to variation in exposures, referral patterns and performance and interpretation of investigations...
October 4, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27688299/effects-of-whole-body-vibration-on-neuromuscular-performance-in-individuals-with-spinal-cord-injury-a-systematic-review
#7
Qiaodan Ji, Hongchen He, Chi Zhang, Chunlan Lu, Yu Zheng, Xiao Tian Luo, Chengqi He
OBJECTIVE: To examine the effects of whole-body vibration on neuromuscular performance in people with spinal cord injury and evaluate the safe and effective vibration protocols. METHODS: PubMed, EMBASE, CINAHL and PEDro were mainly searched for English literatures. Other data sources were ClinicalTrials.gov, Current Controlled Trials and reference lists of all relevant articles. The PEDro scale was used to evaluate the methodological quality, and the Oxford Centre for Evidence-based Medicine level of evidence was used to assess the level of evidence...
September 29, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27676820/evaluation-of-disabilities-and-rehabilitation-needs-after-critical-illness-impact-of-an-intensive-care-unit-follow-up-clinic-in-the-university-hospital-of-angers
#8
Tiphaine Bourseau, Flavie Fremondière, Valérie Dubus, Bénédicte Gohier, Dewi Le Gal, Fabien Cave, Isabelle Richard, Nicolas Lerolle
OBJECTIVE: After critical illness, some survivors experience long-term physical, functional, neurocognitive and/or mental health impairments, which has been termed "Post-Intensive Care syndrome" (PICS) [1]. A specific follow-up is required and many specialized follow-up clinics have been created both abroad and in France. The aim of this study is to evaluate long-term outcomes after critical illness, through the International Classification of Functioning, Disability and Health, and to analyse rehabilitation needs after intensive care unit (ICU) discharge...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27492162/volumetric-muscle-loss
#9
Beth E Pollot, Benjamin T Corona
Volumetric muscle loss (VML) injury is prevalent in severe extremity trauma and is an emerging focus area among orthopedic and regenerative medicine fields. VML injuries are the result of an abrupt, frank loss of tissue and therefore of different etiology from other standard rodent injury models to include eccentric contraction, ischemia reperfusion, crush, and freeze injury. The current focus of many VML-related research efforts is to regenerate the lost muscle tissue and thereby improve muscle strength. Herein, we describe a VML model in the anterior compartment of the hindlimb that is permissible to repeated neuromuscular strength assessments and is validated in mouse, rat, and pig...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27451279/reply-to-senefeld-and-hunter-physiology-in-medicine-neuromuscular-consequences-of-diabetic-neuropathy-the-authors-reply
#10
Matti D Allen, Timothy J Doherty, Charles L Rice, Kurt Kimpinski
No abstract text is available yet for this article.
July 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27392673/-not-available
#11
Elodie Blanchard, Manuel Tunon de Lara
Pholcodine is an opioid that has been widely used worldwide since 1950 for the treatment of non-productive cough in children and adults. The results of early preclinical studies but also those of recent clinical trials have shown the antitussive efficacy of pholcodine to be superior to that of codeine, of longer duration, and with an equivalent or safer toxicity profile. Also, there is no risk of addiction. Concern had been raised over a possible cross-sensitisation with neuromuscular blocking agents. While a recent assessment of the available data by the European Medicines Agency (EMA) has confirmed the favourable risk-benefit ratio of pholcodine, further studies are needed to clear this point...
March 2013: Thérapie
https://www.readbyqxmd.com/read/27358839/rapid-return-of-spontaneous-respiration-after-general-anesthesia-with-sugammadex-in-a-patient-with-myasthenia-gravis
#12
Raing Kyu Kim, Soon Yul Kim
Myasthenia gravis causes weakness and fatigue of the skeletal muscles, including respiratory muscles. When immobile surgical fields are needed, neuromuscular blocking agents (NMBAs) are often administered to block muscle activity, leading to an immobile surgical field and respiratory arrest. Acetylcholinesterase inhibitors are administered to reverse the muscle block, promoting spontaneous respiration for patient recovery. If immobile surgical fields are required in myasthenic patient operations, NMBAs should be administered...
March 2016: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/27298317/identification-of-plant-derived-alkaloids-with-therapeutic-potential-for-myotonic-dystrophy-type-i
#13
Ruben Herrendorff, Maria Teresa Faleschini, Adeline Stiefvater, Beat Erne, Tatiana Wiktorowicz, Frances Kern, Matthias Hamburger, Olivier Potterat, Jochen Kinter, Michael Sinnreich
Myotonic dystrophy type I (DM1) is a disabling neuromuscular disease with no causal treatment available. This disease is caused by expanded CTG trinucleotide repeats in the 3' UTR of the dystrophia myotonica protein kinase gene. On the RNA level, expanded (CUG)n repeats form hairpin structures that sequester splicing factors such as muscleblind-like 1 (MBNL1). Lack of available MBNL1 leads to misregulated alternative splicing of many target pre-mRNAs, leading to the multisystemic symptoms in DM1. Many studies aiming to identify small molecules that target the (CUG)n-MBNL1 complex focused on synthetic molecules...
August 12, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27251916/neuromuscular-conditions-for-physicians-what-you-need-to-know
#14
Laura Edwards, Margaret Phillips
The Royal College of Physicians (RCP) and the British Society of Rehabilitation Medicine co-hosted a meeting entitled 'Neuromuscular conditions for physicians - what you need to know' at the RCP on 30 November 2015. There was a series of talks, ranging from in-depth genetic and molecular descriptions of pathology to multidisciplinary management of chronic neuromuscular conditions, which stimulated lively debate and discussion. Some overarching themes emerged from the day, most notably: i) the changing expectations and survival rates in Duchenne muscular dystrophy (DMD), which are transforming this disorder into an adult as much as a paediatric condition; ii) the need for integrated management and good communication -between services - whether primary, secondary and tertiary care, medical teams and intensivists, or the multiple teams involved in providing treatment to neuromuscular patients; and iii) in line with the above, the essential need for streamlining care such that patients can avoid spending most of their time attending outpatient appointments, and instead concentrate on living full lives and exploring educational, occupational, leisure and social opportunities...
June 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/27238858/establishing-high-quality-reference-values-for-nerve-conduction-studies-a-report-from-the-normative-data-task-force-of-the-american-association-of-neuromuscular-electrodiagnostic-medicine
#15
Timothy Dillingham, Shan Chen, Michael Andary, Ralph Buschbacher, David Del Toro, Benn Smith, Kuno Zimmermann, Yuen So
INTRODUCTION: There are not uniform standards for nerve conduction testing across the United States. The objective of this study is to present a set of methodologically sound criteria to evaluate the literature for the purpose of identifying high-quality normative nerve conduction studies (NCS) suitable for widespread use. METHODS: The Normative Data Task Force (NDTF) was formed to review published studies on methodological issues related to NCS. A set of criteria was then developed to evaluate the literature...
September 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27217604/anticonvulsant-effect-of-the-aqueous-extract-and-essential-oil-of-carum-carvi-l-seeds-in-a-pentylenetetrazol-model-of-seizure-in-mice
#16
Alireza Showraki, Masoumeh Emamghoreishi, Somayeh Oftadegan
BACKGROUND: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice. METHODS: The anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 100, 200, and 400 mg/kg, i.p.) of caraway were assessed using pentylenetetrazol (PTZ; 95 mg/kg i...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27173448/muscle-moment-arms-and-sensitivity-analysis-of-a-mouse-hindlimb-musculoskeletal-model
#17
James P Charles, Ornella Cappellari, Andrew J Spence, Dominic J Wells, John R Hutchinson
Musculoskeletal modelling has become a valuable tool with which to understand how neural, muscular, skeletal and other tissues are integrated to produce movement. Most musculoskeletal modelling work has to date focused on humans or their close relatives, with few examples of quadrupedal animal limb models. A musculoskeletal model of the mouse hindlimb could have broad utility for questions in medicine, genetics, locomotion and neuroscience. This is due to this species' position as a premier model of human disease, having an array of genetic tools for manipulation of the animal in vivo, and being a small quadruped, a category for which few models exist...
October 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27138673/hypoxaemia-on-arrival-in-a-multidisciplinary-intensive-care-unit
#18
Kim De Vasconcellos, David Lee Skinner, Dhivendra Singh
BACKGROUND: Transport of the critically ill patient poses the risk of numerous complications. Hypoxaemia is one such serious adverse event and is associated with potential morbidity and mortality. It is, however, potentially preventable. OBJECTIVE: To determine the incidence of hypoxaemia on arrival in a tertiary multidisciplinary intensive care unit (ICU) and to identify risk factors for this complication. METHOD: A retrospective observational study was conducted at King Edward VIII Hospital, Durban, South Africa, from May 2013 to February 2014...
May 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27072558/external-fixation-of-paediatric-subtrochanteric-fractures-using-calcar-rather-than-neck-pins
#19
Sherif Galal
UNLABELLED: Subtrochanteric femoral fractures in children are uncommon and have received limited attention in the literature. Its treatment is controversial, and different options are available: traction, spica casting, internal fixation and external fixation. The aim of this study is to present our results with external fixation of subtrochanteric femoral fractures in children using Ilizarov frame. Between January 2012 and January 2014, 14 patients with closed subtrochanteric femoral fractures were treated in Cairo University School of Medicine Teaching Hospital...
August 2016: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/27033376/limb-girdle-muscular-dystrophies-international-collaborations-for-translational-research
#20
REVIEW
Rachel Thompson, Volker Straub
The limb-girdle muscular dystrophies (LGMDs) are a diverse group of genetic neuromuscular conditions that usually manifest in the proximal muscles of the hip and shoulder girdles. Since the identification of the first gene associated with the phenotype in 1994, an extensive body of research has identified the genetic defects responsible for over 30 LGMD subtypes, revealed an increasingly varied phenotypic spectrum, and exposed the need to move towards a systems-based understanding of the molecular pathways affected...
May 2016: Nature Reviews. Neurology
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