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Neuromuscular medicine

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https://www.readbyqxmd.com/read/29765874/predictive-variables-for-sonographically-guided-corticosteroid-injection-in-mild-to-moderate-carpal-tunnel-syndrome
#1
Seong Yun Chung, Jung Min Kwak, Seok Kang, Seong-Ho Son, Jae Do Kim, Joon Shik Yoon
Objective: To assess the predictive variables after sonographically guided corticosteroid injection in carpal tunnel syndrome. Methods: A prospective, observational study was carried out on 25 wrists of 20 consecutive patients with carpal tunnel syndrome, confirmed by the American Association of Neuromuscular and Electrodiagnostic Medicine criteria, which includes clinical history, symptoms, and evidence of slowing of distal median nerve conduction. Visual analogue scale (VAS) and Boston Carpal Tunnel Questionnaire (BCTQ) were asked to the patients before and 4 weeks after the procedure...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29759488/neuromuscular-disorders-and-the-role-of-the-clinical-electrophysiologist
#2
REVIEW
Haisam Ismail, Elizabeth Raynor, Peter Zimetbaum
Cardiac involvement is common and may be the presenting or predominant manifestation in a variety of neuromuscular disorders, most notably the inherited muscle disorders, or muscular dystrophies. Cardiac manifestations of the neuromuscular disorders result from pathological involvement of the myocardium and the cardiac conduction system, with resulting cardiomyopathy or rhythm disturbances including supraventricular arrhythmias, life-threatening ventricular arrhythmias, and sudden cardiac death. Many of these neuromuscular disorders are rare and may be unrecognized by even experienced specialists in internal and cardiovascular medicine...
October 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29701915/complete-adult-neurogenesis-within-a-wallerian-degenerating-nerve-expressed-as-an-ectopic-ganglion
#3
Tomonori Nakano, Shigeru Kurimoto, Shuichi Kato, Kenichi Asano, Takuma Hirata, Hiroshi Kiyama, Hitoshi Hirata
Neurogenesis in the adult peripheral nervous system remains to be demonstrated. We transplanted embryonic neural stem cells into a Wallerian-degenerating nerve graft, and observed development of a nodular structure consisting of neurons, glia, and Schwann cells. Histological analysis revealed a structure loosely resembling the spinal cord, including a synaptic network that formed along the neuron. Furthermore, the new axons re-innervated the paralyzed muscle, forming both de novo and revived neuromuscular junctions...
April 27, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29690886/loss-of-alpha-smooth-muscle-actin-expression-associated-with-chronic-intestinal-pseudo-obstruction-in-a-young-miniature-bull-terrier
#4
Gian Enrico Magi, Francesca Mariotti, Sara Berardi, Andrea Piccinini, Cecilia Vullo, Angela Palumbo Piccionello, Giacomo Rossi
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome in veterinary medicine characterized by severe intestinal dysmotility without evidence of mechanical occlusion of the intestinal lumen. The exact pathogenesis of CIPO is unknown. CASE PRESENTATION: A 1-year-old male Miniature Bull Terrier dog was presented with a history of chronic weight loss, regurgitation, lethargy, vomiting and diarrhea. The dog was submitted for exploratory laparotomy...
April 24, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29674282/bioenergetics-mechanisms-regulating-muscle-stem-cell-self-renewal-commitment-and-function
#5
REVIEW
Phablo Abreu
Muscle stem cells or satellite cells are crucial for muscle maintenance and repair. These cells are mitotically quiescent and uniformly express the transcription factor Pax7, intermittently entering the cell cycle to give rise to daughter myogenic precursors cells and fuse with neighboring myofibers or self-renew, replenishing the stem cell pool in adult skeletal muscle. Pivotal roles of muscle stem cells in muscle repair have been uncovered, but it still remains unclear how muscle stem cell self-renewal is molecularly regulated and how muscle stem cells maintain muscle tissue homeostasis...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29662761/inflammation-and-age-associated-skeletal-muscle-deterioration-sarcopaenia
#6
REVIEW
Jinyu Wang, Kwok-Sui Leung, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Ageing is accompanied by chronic inflammatory responses due to elevated circulatory inflammatory cytokine production. Several inflammatory cytokines have been shown to be responsible for a decrease in muscle mass. However, little is known about the possible relationship between inflammation and sarcopaenia. This review aims to summarise the existing evidence about inflammation and sarcopaenia. Sarcopaenia is defined as an age-related decrease of muscle mass and/or muscle strength; it is caused by multiple factors, such as skeletal muscle atrophy, neuromuscular junction degeneration, hormone imbalance, cytokine imbalance, protein synthesis and proteolysis...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29649068/is-exercise-the-right-medicine-for-dystrophic-muscle
#7
Hannah R Spaulding, Joshua T Selsby
INTRODUCTION: Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by a dystrophin protein deficiency. Dystrophin functions to stabilize and protect the muscle fiber during muscle contraction, thus the absence of functional dystrophin protein leads to muscle injury. DMD patients experience progressive muscle necrosis, loss of function, and ultimately succumb to respiratory failure or cardiomyopathy. Exercise is known to improve muscle health and strength in healthy individuals as well as positively impact other systems...
April 11, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29625093/is-going-beyond-rasch-analysis-necessary-to-assess-the-construct-validity-of-a-motor-function-scale
#8
Tiffanie Guillot, Sylvain Roche, Pascal Rippert, Dalil Hamroun, Jean Iwaz, René Ecochard, Carole Vuillerot
OBJECTIVE: Examine whether a Rasch analysis is sufficient to establish the construct validity of the Motor Function Measure (MFM) and discuss whether weighting the MFM item scores would improve the MFM construct validity. DESIGN: Observational cross-sectional multicenter study. SETTING: 23 physical medicine departments, neurology departments, or reference centers for neuromuscular diseases PARTICIPANTS: 911 patients (aged 6 to 60 years) with Charcot-Marie-Tooth disease (CMT), facio-scapulo-humeral dystrophy (FSHD), or myotonic dystrophy type 1 (DM1) INTERVENTIONS: None...
April 3, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29615933/dexamethasone-protects-against-tourniquet-induced-acute-ischemia-reperfusion-injury-in-mouse-hindlimb
#9
Ryan M Corrick, Huiyin Tu, Dongze Zhang, Aaron N Barksdale, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexamethasone, an anti-inflammatory drug, on tourniquet-induced acute IR injury in mouse hindlimb...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29557685/magnesium-sulfate-and-calcium-channel-blocking-drugs-as-antidotes-for-acute-organophosphorus-insecticide-poisoning-a-systematic-review-and-meta-analysis
#10
Miran Brvar, Ming Yin Chan, Andrew H Dawson, Richard R Ribchester, Michael Eddleston
INTRODUCTION: Treatment of acute organophosphorus or carbamate insecticide self-poisoning is often ineffective, with tens of thousands of deaths occurring every year. Researchers have recommended the addition of magnesium sulfate or calcium channel blocking drugs to standard care to reduce acetylcholine release at cholinergic synapses. OBJECTIVE: We aimed to review systematically the evidence from preclinical studies in animals exposed to organophosphorus or carbamate insecticides concerning the efficacy of magnesium sulfate and calcium channel blocking drugs as therapy compared with placebo in reducing mortality or clinical features of poisoning...
March 20, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29516701/-clinical-effectiveness-of-intradermal-needle-embedding-therapy-for-swallowing-function-in-stroke-patients-with-dysphagia
#11
Dan Sun, Wei Xu, Na Chen, Shi-Min Li, Tian Fu
OBJECTIVE: To observe the clinical efficacy of intradermal needle-embedding therapy in the treatment of dysphagia in stroke patients. METHODS: A total of 80 stroke patients with dysphagia were randomly divided into treatment group and control group ( n = 40 in each). The control group was treated with conventional medicines, neuromuscular electrical stimulation of the bilateral midlines of the neck and swallowing function training, and the treatment group treated by intradermal needle-embedding at Lianquan (CV 23), Jialianquan-point, Yifeng (TE 17), Ashi-point, etc...
February 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29510454/needle-electromyography-practice-patterns-in-patients-taking-novel-oral-anticoagulants-a-survey-based-study
#12
Ikjae Lee, Hani Kushlaf
INTRODUCTION: This study sought to evaluate needle electromyography (EMG) practice patterns among electromyographers with patients taking novel oral anticoagulants (NOAC). METHODS: A survey questionnaire was sent to members of the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) via email web link. Anonymous survey responses were collected through an online website. RESULTS: Fifty-eight AANEM members responded, 28 (48%) of whom worked at a teaching hospital and 30 (52%) of whom worked in a private setting...
March 6, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29461411/sequencing-effects-of-object-control-and-locomotor-skill-during-integrated-neuromuscular-training-in-6-7-year-old-children
#13
Michael J Duncan, Thomas Hames, Emma L J Eyre
This study examined whether scheduling of object control (e.g., throwing, catching) and locomotor skills (e.g., running, jumping), within an integrated neuromuscular training (INT) program, results in different responses in motor competence, muscular fitness and perceived motor competence in 6-7 year old children. Seventy seven boys and 63 girls (n = 140) from 3 primary schools were randomised into three, 10-week interventions, Loco First (n = 50) where locomotor skills were performed first followed by object control skills; Object First (n =48) where object control skills were performed first followed by locomotor skills or a control group (n =42, CON) who undertook school Physical Education...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29389696/reliability-and-validity-of-a-medicine-ball-contained-accelerometer-for-measuring-upper-body-neuromuscular-performance
#14
Gregory Roe, William Shaw, Joshua Darrall-Jones, Padraic J Phibbs, Dale Read, Jonathon J Weakley, Kevin Till, Ben Jones
The aim of the study was to assess the between-day reliability and validity of a medicine ball contained-accelerometer (MBA) for assessing upper-body neuromuscular performance during a throwing task. Ten professional rugby union players partook in the study. Between-day reliability was assessed from the best score attained during 2 sets of 3 throws, on 2 testing occasions separated by 7 days. Validity was assessed against a criterion measure (Optioelectronic system) during 75 throws from a sub group of three participants...
January 30, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29377176/agrin-and-lrp4-antibodies-as-new-biomarkers-of-myasthenia-gravis
#15
REVIEW
Min Yan, Guang-Lin Xing, Wen-Cheng Xiong, Lin Mei
Myasthenia gravis (MG) is a common disorder that affects the neuromuscular junction. It is caused by antibodies against acetylcholine receptor and muscle-specific tyrosine kinase; however, some MG patients do not have antibodies against either of the proteins. Recent studies have revealed antibodies against agrin and its receptor LRP4-both critical for neuromuscular junction formation and maintenance-in MG patients from various populations. Results from experimental autoimmune MG animal models indicate that anti-LRP4 antibodies are causal to MG...
February 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29334308/neuromuscular-degenerative-effects-of-ankaferd-blood-stopper-%C3%A2-in-mouse-sciatic-nerve-model
#16
Ramazan Üstün, Elif Kaval Oğuz, Çağrı Delilbaşı, Ayşe Şeker, Filiz Taşpınar, Mehmet Reşit Öncü, Ahmet Regaip Oğuz
PURPOSE: Ankaferd Blood Stopper® (ABS), a licenced medicinal herbal extract, is commonly used as an effective topical haemostatic agent. This study is designed to investigate whether topical ABS application may cause peripheral nerve degeneration and neuromuscular dysfunction in a mouse sciatic nerve model. METHODS: Twenty mice were randomly divided into two groups; an ABS treated experimental group and a saline-treated control group. Left sciatic nerves were treated with 0...
December 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/29332237/acute-acetaminophen-ingestion-improves-performance-and-muscle-activation-during-maximal-intermittent-knee-extensor-exercise
#17
Paul T Morgan, Joanna L Bowtell, Anni Vanhatalo, Andrew M Jones, Stephen J Bailey
AIM: Acetaminophen is a commonly used medicine for pain relief and emerging evidence suggests that it may improve endurance exercise performance. This study investigated some of the physiological mechanisms by which acute acetaminophen ingestion might blunt muscle fatigue development. METHODS: Thirteen active males completed 60 × 3 s maximum voluntary contractions (MVC) of the knee extensors with each contraction separated by a 2 s passive recovery period...
March 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29303362/the-demands-of-amputee-soccer-impair-muscular-endurance-and-power-indices-but-not-match-physical-performance
#18
Mário A M Simim, Gustavo R da Mota, Moacir Marocolo, Bruno V C da Silva, Marco Túlio de Mello, Paul S Bradley
We investigated the match demands (distances covered and acute physiological responses) of amputee soccer and its impact on muscular endurance and power. Measures such as heart rate, blood lactate concentration, subjective rating of perceived exertion, and time-motion characteristics were recorded in 16 Brazilian amputee soccer players during matches. Before and after matches, players completed a battery of tests: push-ups, countermovement vertical jump performance, and medicine ball throwing. Small differences were found between the first and second half for the distance covered in total and across various speed categories...
January 1, 2018: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/29258769/calcium-and-vitamin-d-in-human-health-hype-or-real
#19
REVIEW
Sunil J Wimalawansa, Mohammed S Razzaque, Nasser M Al-Daghri
The incidence and prevalence of vitamin D deficiency are increasing worldwide. It is estimated that over 50% of the world's population have low vitamin D (i.e., hypovitaminosis D; serum levels below 30 ng/mL). In vitamin D inadequacy, human physiological systems work inefficiently. In humans, 80% of the vitamin D is synthesized in the presence of ultraviolet rays from sunlight; for the rest, we rely on diet and nowadays, supplements. The latter becomes important when one is exposed to less than optimal amounts of sunlight, inability to generate vitamin D in the skin efficiently, and/or having conditions that lead to decreased intestinal absorption or increased catabolism of vitamin D...
December 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29214627/a-12-month-descriptive-analysis-of-emergency-intubations-at-brooke-army-medical-center-a-national-emergency-airway-registry-study
#20
Michael D April, Steven G Schauer, Calvin A Brown Rd, Patrick C Ng, Jessie Fernandez, Andrea E Fantegrossi, Joseph K Maddry, Shane Summers, Daniel J Sessions, Robert M Barnwell, Mark Antonacci
Emergency airway management is a critical skill for military healthcare providers. Our goal was to describe the Emergency Department (ED) intubations at Brooke Army Medical Center (BAMC) over a 12-month period. MATERIAL AND METHODS: Physicians performing endotracheal intubations in the BAMC ED complete data collection forms for each intubation event as part of the National Emergency Airway Registry, including patient demographics, intubation techniques, success and failure rates, adverse events, and patient disposition...
October 2017: U.S. Army Medical Department Journal
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