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A20 AND infection

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https://www.readbyqxmd.com/read/29129932/the-vaccinia-virus-dna-polymerase-structure-provides-insights-into-the-mode-of-processivity-factor-binding
#1
Nicolas Tarbouriech, Corinne Ducournau, Stephanie Hutin, Philippe J Mas, Petr Man, Eric Forest, Darren J Hart, Christophe N Peyrefitte, Wim P Burmeister, Frédéric Iseni
Vaccinia virus (VACV), the prototype member of the Poxviridae, replicates in the cytoplasm of an infected cell. The catalytic subunit of the DNA polymerase E9 binds the heterodimeric processivity factor A20/D4 to form the functional polymerase holoenzyme. Here we present the crystal structure of full-length E9 at 2.7 Å resolution that permits identification of important poxvirus-specific structural insertions. One insertion in the palm domain interacts with C-terminal residues of A20 and thus serves as the processivity factor-binding site...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29099284/nf-%C3%AE%C2%BAb-regulated-ubiquitin-editing-enzyme-a20-paves-the-way-for-infection-persistency
#2
Michelle C C Lim, Gunter Maubach, Michael Naumann
No abstract text is available yet for this article.
November 3, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28820283/n-3-pufas-induce-inflammatory-tolerance-by-formation-of-keap1-containing-sqstm1-p62-bodies-and-activation-of-nfe2l2
#3
Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo, Geir Bjørkøy
Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have known anti-inflammatory effects. The balance of pro- and anti-inflammatory processes is coordinated by macrophages and macroautophagy/autophagy has recently emerged as a cellular process that dampens inflammation. Here we report that the n-3 PUFA docosahexaenoic acid (DHA) transiently induces cytosolic speckles of the autophagic receptor SQSTM1/p62 (sequestosome 1) (described as SQSTM1/p62-bodies) in macrophages...
October 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28814524/mutation-of-the-putative-immunosuppressive-domain-of-the-retroviral-envelope-glycoprotein-compromises-infectivity
#4
Urszula Eksmond, Bryony Jenkins, Julia Merkenschlager, Walther Mothes, Jonathan P Stoye, George Kassiotis
The envelope glycoprotein of diverse endogenous and exogenous retroviruses is considered inherently immunosuppressive. Extensive work mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive domain (ISD), in the transmembrane (TM) subunit of the envelope glycoprotein and identified two naturally polymorphic key residues that afford immunosuppressive activity to distinct envelope glycoproteins. Concurrent mutation of these two key residues (E14R and A20F) in the envelope glycoprotein of the Friend murine leukemia virus (F-MLV) ISD has been reported to abolish its immunosuppressive activity, without affecting its fusogenicity, and to weaken the ability of the virus to replicate specifically in immunocompetent hosts...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28765172/leishmania-donovani-inhibits-inflammasome-dependent-macrophage-activation-by-exploiting-the-negative-regulatory-proteins-a20-and-ucp2
#5
Anand Kumar Gupta, Kuntal Ghosh, Shreyasi Palit, Jayita Barua, Pijush K Das, Anindita Ukil
In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1β over the infected control. Moreover, administering anti-IL-1β antibody to infected Amp B-treated mice showed significantly less parasite clearance. Investigation revealed that Leishmania inhibits stimuli-induced expression of a multiprotein signaling platform, NLRP3 inflammasome, which in turn inhibits caspase-1 activation mediated maturation of IL-1β from its pro form. Attenuation of NLRP3 and pro-IL-1β in infection was found to result from decreased NF-κB activity...
August 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28735964/bovine-a20-gene-overexpression-during-bovine-viral-diarrhea-virus-1-infection-blocks-nf-%C3%AE%C2%BAb-pathway-in-mdbk-cells
#6
Melina Villalba, Nivia Canales, Nicolas Maldonado, Carola Otth, Fernanda Fredericksen, Pablo Garcés, Cristopher Stepke, Valentina Arriagada, Víctor H Olavarría
Viruses have developed cellular strategies to ensure progeny survival. One of the most interesting is immune camouflage, where the virus triggers a controlled-intensity immune response that prevents total destruction of the infected cell, thus "winning time" for the virus. This study explored the regulatory contexts of the bovine A20 gene during bovine viral diarrhea virus (BVDV)-1 infection, using IL-8 as an immune-response sentinel molecule. Assessments were conducted through RT-qPCR, Western blotting, gene silencing/overexpression, luciferase assays, and the use of pharmacological inhibitors, among other approaches...
July 21, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28574503/pathogen-induced-ubiquitin-editing-enzyme-a20-bifunctionally-shuts-off-nf-%C3%AE%C2%BAb-and-caspase-8-dependent-apoptotic-cell-death
#7
Michelle C C Lim, Gunter Maubach, Olga Sokolova, Michael H Feige, Rolf Diezko, Jörn Buchbinder, Steffen Backert, Dirk Schlüter, Inna N Lavrik, Michael Naumann
The human pathogen Helicobacter pylori infects more than half of the world's population and is a paradigm for persistent yet asymptomatic infection but increases the risk for chronic gastritis and gastric adenocarcinoma. For successful colonization, H. pylori needs to subvert the host cell death response, which serves to confine pathogen infection by killing infected cells and preventing malignant transformation. Infection of gastric epithelial cells by H. pylori provokes direct and fast activation of the proinflammatory and survival factor NF-κB, which regulates target genes, such as CXCL8, BIRC3 and TNFAIP3...
September 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28500687/epidemiological-analysis-and-follow-up-of-human-rhinovirus-infection-in-children-with-asthma-exacerbation
#8
Shou-Yan Zheng, Li-Li Wang, Luo Ren, Jian Luo, Wei Liao, En-Mei Liu
To determine the prevalence of human rhinovirus (HRV) infection in children with acute asthma exacerbations, investigation of HRV viral load and severity of asthma exacerbations is also required. Nasopharyngeal aspirates and swabs were collected and assessed for respiratory viruses. HRV-positive samples were sequenced to identify types and determine viral load. Outpatients with asthma exacerbations underwent follow-up evaluations, their swabs were collected and clinical outcomes were recorded at their next clinic visit 4 weeks later...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28408611/correction-for-doukas-and-sarnow-escape-from-transcriptional-shutoff-during-poliovirus-infection-nf-%C3%AE%C2%BAb-responsive-genes-i%C3%AE%C2%BAba-and-a20
#9
Tammy Doukas, Peter Sarnow
No abstract text is available yet for this article.
May 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28405612/microrna-125a-and-b-inhibit-a20-and-mavs-to-promote-inflammation-and-impair-antiviral-response-in-copd
#10
Alan C-Y Hsu, Kamal Dua, Malcolm R Starkey, Tatt-Jhong Haw, Prema M Nair, Kristy Nichol, Nathan Zammit, Shane T Grey, Katherine J Baines, Paul S Foster, Philip M Hansbro, Peter A Wark
Influenza A virus (IAV) infections lead to severe inflammation in the airways. Patients with chronic obstructive pulmonary disease (COPD) characteristically have exaggerated airway inflammation and are more susceptible to infections with severe symptoms and increased mortality. The mechanisms that control inflammation during IAV infection and the mechanisms of immune dysregulation in COPD are unclear. We found that IAV infections lead to increased inflammatory and antiviral responses in primary bronchial epithelial cells (pBECs) from healthy nonsmoking and smoking subjects...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28363868/neoagarooligosaccharides-prevent-septic-shock-by-modulating-a20-and-cyclooxygenase-2-mediated-interleukin-10-secretion-in-a-septic-shock-mouse-model
#11
Da Rae Kang, Gun Young Yoon, Joon Cho, Seung Jun Lee, Su Jin Lee, Hee Jo Park, Tae Heung Kang, Hee Dong Han, Won Sun Park, Young Kyung Yoon, Yeong-Min Park, In Duk Jung
Analysis of the signaling mechanism triggered by endotoxin-mediated toll-like receptor-4 activation using immune cell systems or rodent models may help identify potential agents for the prevention of Gram-negative bacteria infection. β-agarase cleaves the β-1,4-linkages of agar to produce neoagarooligosaccharides (NAOs), which have various physiological functions. The aim of this study was to investigate the efficacy of NAOs in preventing experimental sepsis caused by the administration of endotoxin or Gram-negative bacteria...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28355270/the-nf-%C3%AE%C2%BAb-dependent-and-independent-transcriptome-and-chromatin-landscapes-of-human-coronavirus-229e-infected-cells
#12
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M Lienhard Schmitz, Michael Kracht
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was studied in human coronavirus 229E (HCoV-229E)-infected A549 and HuH7 cells, respectively, revealing a core signature of upregulated genes in these cells. Compared to treatment with the prototypical inflammatory cytokine interleukin(IL)-1, HCoV-229E replication was found to attenuate the inducible activity of the transcription factor (TF) NF-κB and to restrict the nuclear concentration of NF-κB subunits by (i) an unusual mechanism involving partial degradation of IKKβ, NEMO and IκBα and (ii) upregulation of TNFAIP3 (A20), although constitutive IKK activity and basal TNFAIP3 expression levels were shown to be required for efficient virus replication...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28210256/transcriptomic-analysis-of-the-innate-antiviral-immune-response-in-porcine-intestinal-epithelial-cells-influence-of-immunobiotic-lactobacilli
#13
Leonardo Albarracin, Hisakazu Kobayashi, Hikaru Iida, Nana Sato, Tomonori Nochi, Hisashi Aso, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena
Lactobacillus rhamnosus CRL1505 and Lactobacillus plantarum CRL1506 are immunobiotic strains able to increase protection against viral intestinal infections as demonstrated in animal models and humans. To gain insight into the host-immunobiotic interaction, the transcriptomic response of porcine intestinal epithelial (PIE) cells to the challenge with viral molecular associated pattern poly(I:C) and the changes in the transcriptomic profile induced by the immunobiotics strains CRL1505 and CRL1506 were investigated in this work...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28199901/cd44-deficiency-enhanced-streptococcus-equi-ssp-zooepidemicus-dissemination-and-inflammation-response-in-a-mouse-model
#14
Qiang Fu, Pingping Xiao, Yaosheng Chen, Zigong Wei, Xiaohong Liu
Streptococcus equi ssp. zooepidemicus (S. zooepidemicus) is responsible for peritonitis, septicemia, meningitis, arthritis and several other serious diseases in various species. Recent studies have demonstrated that CD44 is implicated in the process of host defense against pathogenic microorganisms. In the present study, the role of CD44 in the host response to S. zooepidemicus infection was investigated in a mouse model. Upon intraperitoneal infection with S. zooepidemicus, the expression of CD44 on the peritoneal exudate cells from wild-type (WT) mice was increased...
February 9, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28110818/cystatin-c-peptidomimetic-derivative-with-antimicrobial-properties-as-a-potential-compound-against-wound-infections
#15
Michał Pikuła, Maria Smużyńska, Adam Krzystyniak, Maciej Zieliński, Paulina Langa, Milena Deptuła, Adriana Schumacher, Jakub Łata, Mirosława Cichorek, Anders Grubb, Piotr Trzonkowski, Franciszek Kasprzykowski, Sylwia Rodziewicz-Motowidło
A peptidomimetic called A20 (Cystapep 1) structurally based upon the N-terminal fragment of human cystatin C is known to have strong antibacterial properties. A20 is characterized by high activity against several bacterial strains often isolated from infected wounds, including methicillin-resistant S. aureus (MRSA). In this work we wanted to explore the therapeutic potential of A20 in the treatment of wound infections. We examined, cytotoxicity, allergenicity and impact of A20 on the proliferation and viability of human keratinocytes...
February 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28088970/-tnfaip3-deletion-status-in-classical-hodgkin-lymphoma-and-its-relation-to-epstein-barr-virus
#16
Y F Shi, Z F Gao, C L Liu, M Li, D M Lin, L X Zhou, Y M Lai, X L Liu, X Huang
Objective: To investigate the TNFAIP3/A20 abnormalities and its association with Epstein-Barr virus (EBV) in classical Hodgkin lymphoma (CHL). Methods: Formalin-fixed, paraffinembedded tissue blocks of 54 CHL patients were collected and subjected to the construction of tissue microarray (TMA) for further analyses. EBV status was evaluated by in situ hybridization (ISH) for EBER1/2 and immunohistochemistry (IHC) with anti-LMP-1 antibody. Fluorescence in situ hybridization (FISH) and IHC were performed to determine the copy number alterations of TNFAIP3 and A20 protein expression respectively...
December 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28039858/arabidopsis-stress-associated-protein-9-mediates-biotic-and-abiotic-stress-responsive-aba-signaling-via-the-proteasome-pathway
#17
Miyoung Kang, Seonghee Lee, Haggag Abdelmageed, Angelika Reichert, Hee-Kyung Lee, Mohamed Fokar, Kirankumar S Mysore, Randy D Allen
Arabidopsis thaliana Stress Associated Protein 9 (AtSAP9) is a member of the A20/AN1 zinc finger protein family known to play important roles in plant stress responses and in the mammalian immune response. Although SAPs of several plant species were shown to be involved in abiotic stress responses, the underlying molecular mechanisms are largely unknown, and little is known about the involvement of SAPs in plant disease responses. Expression of SAP9 in Arabidopsis is up-regulated in response to dehydration, cold, salinity and abscisic acid (ABA), as well as pathogen infection...
December 31, 2016: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28004776/a20-curtails-primary-but-augments-secondary-cd8-t-cell-responses-in-intracellular-bacterial-infection
#18
Sissy Just, Gopala Nishanth, Jörn H Buchbinder, Xu Wang, Michael Naumann, Inna Lavrik, Dirk Schlüter
The ubiquitin-modifying enzyme A20, an important negative feedback regulator of NF-κB, impairs the expansion of tumor-specific CD8(+) T cells but augments the proliferation of autoimmune CD4(+) T cells. To study the T cell-specific function of A20 in bacterial infection, we infected T cell-specific A20 knockout (CD4-Cre A20(fl/fl)) and control mice with Listeria monocytogenes. A20-deficient pathogen-specific CD8(+) T cells expanded stronger resulting in improved pathogen control at day 7 p.i. Imaging flow cytometry revealed that A20-deficient Listeria-specific CD8(+) T cells underwent increased apoptosis and necroptosis resulting in reduced numbers of memory CD8(+) T cells...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27991595/pgrp-negatively-regulates-nod-mediated-cytokine-production-in-rainbow-trout-liver-cells
#19
Ju Hye Jang, Hyun Kim, Mi Jung Jang, Ju Hyun Cho
Pattern-recognition receptors (PRRs) initiate innate immunity via pathogen recognition. Recent studies suggest that signalling pathways downstream of different PRRs and their crosstalk effectively control immune responses. However, the cross-regulation among PRRs and its effects have yet to be fully described in fish. Here, we examined the crosstalk between OmPGRP-L1, a long form of PGRP in rainbow trout, and other PRRs during pathogenic infections. OmPGRP-L1 expression was increased in RTH-149 cells by iE-DAP and MDP, which are agonists of NOD1 and NOD2, respectively...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27849177/interplay-of-toll-like-receptor-9-myeloid-cells-and-deubiquitinase-a20-in-periodontal-inflammation
#20
Katie E Crump, Jennifer C Oakley, Xia Xia-Juan, Theandra C Madu, Swathi Devaki, Erin C Mooney, Sinem E Sahingur
Toll-like receptor 9 (TLR9)-deficient (TLR9(-/-)) mice are resistant to periodontitis, a disease characterized by a dysbiotic microbiota and deregulated immune response and resulting in tooth loss and various systemic conditions. However, the mechanisms and biological pathways by which TLR9 instigates periodontal inflammation are yet to be identified. In a ligature-induced model of periodontitis, we demonstrate that TLR9(-/-) mice exhibited significantly less alveolar bone loss than their wild-type (WT) counterparts...
January 2017: Infection and Immunity
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