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Candida AND infection

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https://www.readbyqxmd.com/read/28739790/a-cationic-polymer-that-shows-high-antifungal-activity-against-diverse-human-pathogens
#1
Leslie A Rank, Naomi M Walsh, Runhui Liu, Fang Yun Lim, Jin Woo Bok, Mingwei Huang, Nancy P Keller, Samuel H Gellman, Christina M Hull
Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly active against fungal pathogens but not toxic to the host. Host-defense peptides (HDPs) are produced by eukaryotes as a component of the innate immune response to pathogens and have served as inspiration for the development of many new antibacterial compounds...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28737849/antifungal-activity-of-alkaloids-against-candida-albicans
#2
Juliana Noguti, Mersedeh Rajinia, Bruna Raquel Zancope, Maria Carolina Salome Marquezin, Dalia Seleem, Vanessa Pardi, Ramiro M Murata
Candida albicans is a pathogen in the mouth responsible for opportunistic infections that are usually harmless. Natural products have been used to develop several drugs, mostly anticancer and anti-infective agents. Among these, alkaloids have been studied for their medicinal properties. In this study, we examined their antifungal activity against C. albicans in vitro. Among the alkaloids studied in this work, berberine hydrochloride showed the best activity against C. albicans.
August 2016: Journal—California Dental Association
https://www.readbyqxmd.com/read/28735999/results-of-real-time-multiplex-polymerase-chain-reaction-assay-in-renal-transplant-recipients-with-sterile-pyuria
#3
M Sarier, M Demir, S Goktas, I Duman, M Buyukkinaci, Y Yuksel, S Tekin, A H Yavuz, A Sengul
Urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. Patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. Sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. The objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction (rtMPCR) assay in sterile pyuria of renal transplant recipients...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735470/staged-reimplantation-of-a-total-hip-prosthesis-after-co-infection-with-candida-tropicalis-and-staphylococcus-haemolyticus-a-case-report
#4
Sujeesh Sebastian, Rajesh Malhotra, Ashish Pande, Deepak Gautam, Immaculata Xess, Benu Dhawan
Fungal prosthetic joint infection is a rare complication in total joint arthroplasty. There are no established guidelines for management of these infections. We present a case of a 53-year-old male with a hip joint prosthesis co-infected with Candida tropicalis and Staphylococcus haemolyticus. A two-stage exchange arthroplasty was performed. The patient underwent implant removal, debridement, irrigation with saline solution and application of cement spacer impregnated with vancomycin followed by aggressive antimicrobial treatment in first stage...
July 22, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28734712/-candidemia-in-pediatrics-species-distribution-and-antifungal-susceptibility
#5
Luciana B Guzzetti, Cecilia M Vescina, M Florencia Gil, Blanca M Gatti
Serious infections caused by Candida yeasts are frequent in the hospital population. Due to differences in species distribution and antifungal susceptibility testing depending on the geographic area and the type of patient, it is important to study the epidemiology of each institution. For this purpose, we conducted a retrospective, descriptive study on the occurrence of candidemia in the Children's Hospital "Superiora Sor María Ludovica" of the city of La Plata. In a 6-year period (2010-2015), 177 candidemia episodes were recorded...
July 19, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28733532/cancer-risk-in-patients-with-candidiasis-a-nationwide-population-based-cohort-study
#6
Li-Min Chung, Ji-An Liang, Cheng-Li Lin, Li-Min Sun, Chia-Hung Kao
BACKGROUND: Candidiasis and certain types of cancer are related to immunocompromised status. This study aimed to evaluate whether Candida infection (CI) is associated with subsequent cancer risk in Taiwan. METHODS: Data from the National Health Insurance system of Taiwan were used to evaluate the association between CI and cancer risk. The CI cohort comprised 34,829 patients. Each patient was randomly frequency matched with one person from the general population without CI on the basis of age, sex, year of index date of CI diagnosis, and other characteristics to generate the control group...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732804/interactions-of-a-prenylated-flavonoid-from-dalea-elegans-with-fluconazole-against-azole-resistant-candida-albicans
#7
Sebastián Barceló, Mariana Peralta, Maximiliano Calise, Soledad Finck, Gabriela Ortega, Roberto A Diez, José Luis Cabrera, Cristina Pérez
BACKGROUND: The prenylated flavonoid 2', 4'-dihydroxy-5'-(1'″, 1'″-dimethylallyl)-8-prenylpinocembrin (8PP, formerly 6PP) shows antifungal activity, inhibits rhodamine 6G efflux and reverses fluconazole (FCZ) resistance in azole-resistant Candida albicans overexpressing cdr1, cdr2 and mdr1 transporters. PURPOSE AND DESIGN: In this paper, we tried to characterize 8PP in vitro interactions on the cell growth and lethality of C. albicans. We also initiated preliminary in vivo toxicological studies on mice...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28731244/candida-infections-and-interleukin-17-inhibitors-used-in-dermatology
#8
R J Hay
No abstract text is available yet for this article.
July 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28730647/swimming-pools-and-fungi-an-epidemiology-survey-in-polish-indoor-swimming-facilities
#9
Marek Jankowski, Anna Charemska, Rafał Czajkowski
Environmental conditions for swimming facilities may support fungal growth and also may represent a biological risk for users. However, since previously published studies both cleaning procedures and sanitary regulations are likely to have been improved. The aim of the study was to examine whether attendance to public swimming pools was still a risk factor for fungal infection of the skin in Poland. We investigated the occurrence of mycotic species, in a sample from Polish swimming pools. Detection and identification of isolated species were achieved by cultural and morphological methods...
July 20, 2017: Mycoses
https://www.readbyqxmd.com/read/28730378/enzymatic-activity-of-candida-spp-from-oral-cavity-and-urine-in-children-with-nephrotic-syndrome
#10
Dorota Olczak-Kowalczyk, Maria Roszkowska-Blaim, Maria Dąbkowska, Ewa Swoboda-Kopeć, Dariusz Gozdowski, Małgorzata Mizerska-Wasiak, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Oral colonization with Candida spp. is not synonymous with a systemic active infection. The aim of the study was to evaluate enzymatic activity of Candida strains isolated from the oral cavity in patients with nephrotic syndrome (NS) and to compare it with the activity determined in urine. We studied 32 children with NS and 26 control healthy children. Children with NS were treated with glucocorticosteroids, cyclosporin A, mycophenolate mofetil or azathioprine. In all children, API-ZYM enzymatic tests were performed to evaluate hydrolytic enzymes of Candida isolated from the oral cavity and in urine...
July 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28728202/-pyogenic-liver-abscess-changes-of-organisms-and-consequences-for-diagnosis-and-therapy
#11
Alexander Mischnik, Winfried Vincenz Kern, Robert Thimme
Liver abscess is a rare but potentially fatal disease with mortality rates of 2 - 12 %. The spectrum of causative microorganisms varies across the world and is changing due to increasing worldwide travel activity. As a result, previously less frequent pathogens must increasingly be considered in the differential diagnosis. The most common pathogens of liver abscess are so-called abscess streptococci, anaerobes and Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae. Certain clones among the Gram-negatives, typically among Klebsiella spp...
July 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28727728/an-integrative-genomics-approach-identifies-novel-pathways-that-influence-candidaemia-susceptibility
#12
Vasiliki Matzaraki, Mark S Gresnigt, Martin Jaeger, Isis Ricaño-Ponce, Melissa D Johnson, Marije Oosting, Lude Franke, Sebo Withoff, John R Perfect, Leo A B Joosten, Bart Jan Kullberg, Frank L van de Veerdonk, Iris Jonkers, Yang Li, Cisca Wijmenga, Mihai G Netea, Vinod Kumar
Candidaemia is a bloodstream infection caused by Candida species that primarily affects specific groups of at-risk patients. Because only small candidaemia patient cohorts are available, classical genome wide association cannot be used to identify Candida susceptibility genes. Therefore, we have applied an integrative genomics approach to identify novel susceptibility genes and pathways for candidaemia. Candida-induced transcriptome changes in human primary leukocytes were assessed by RNA sequencing. Genetic susceptibility to candidaemia was assessed using the Illumina immunochip platform for genotyping of a cohort of 217 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28725901/zinc-binding-sites-in-pra1-a-zincophore-from-candida-albicans
#13
Dorota Łoboda, Magdalena Rowińska-Żyrek
The aim of this work is to understand the interactions of Zn(ii) with Pra1, a zincophore from Candida albicans, one of the most common causes of serious fungal infections in humans. Pra1 is a 299 amino acid protein, secreted from the fungus to specifically bind Zn(ii) and deliver it to a transmembrane zinc transporter, Zrt1. We take the first step towards understanding the bioinorganic chemistry of this process, by pointing out the Zn(ii) binding sites in Pra1 and understanding the thermodynamics of such interactions...
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28724374/cost-effectiveness-of-isoniazid-preventive-therapy-among-hiv-infected-patients-clinicaly-screened-for-latent-tuberculosis-infection-in-dar-es-salaam-tanzania-a-prospective-cohort-study
#14
Grace A Shayo, Dereck Chitama, Candida Moshiro, Said Aboud, Muhammad Bakari, Ferdinand Mugusi
BACKGROUND: One of the reasons why Isoniazid preventive therapy (IPT) for Tuberculosis (TB) is not widely used in low income countries is concerns on cost of excluding active TB. We analyzed the cost-effectiveness of IPT provision in Tanzania having ruled out active TB by a symptom-based screening tool. METHODS: Data on IPT cost-effectiveness was prospectively collected from an observational cohort study of 1283 HIV-infected patients on IPT and 1281 controls; followed up for 24 months...
July 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28722286/fighting-fungus-with-a-laser-and-a-hose-management-of-a-giant-candida-albicans-implantable-cardioverter-defibrillator-lead-vegetation-with-simultaneous-angiovac-aspiration-and-laser-sheath-lead-extraction
#15
Brandon M Jones, Oussama Wazni, Susan J Rehm, Mehdi H Shishehbor
Infections involving internal cardiac devices can be very challenging to treat, and almost universally require complete device extraction for successful management. Of the pathogens that cause device-related endocarditis, fungi such as Candida albicans are notoriously difficult to manage because of their propensity to produce large vegetations and the need for long-term treatment with potentially toxic medications. Furthermore, individuals who develop fungal, device-associated endocarditis are typically among the most complex patients, with significant comorbidities that place them at high risk for open heart procedures such as surgical device extraction...
July 19, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28720834/chemical-inhibitors-of-candida-albicans-hyphal-morphogenesis-target-endocytosis
#16
Hagit Bar-Yosef, Nora Vivanco Gonzalez, Shay Ben-Aroya, Stephen J Kron, Daniel Kornitzer
Candida albicans is an opportunistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infections. In debilitated and immunocompromised individuals, C. albicans may spread to cause life-threatening systemic infections. Upon contact with serum and at body temperature, C. albicans performs a regulated switch to filamentous morphology, characterized by emergence of a germ tube from the yeast cell followed by mold-like growth of branching hyphae...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720726/mitochondrial-cochaperone-mge1-is-involved-in-regulating-susceptibility-to-fluconazole-in-saccharomyces-cerevisiae-and-candida-species
#17
Liesbeth Demuyser, Erwin Swinnen, Alessandro Fiori, Beatriz Herrera-Malaver, Kevin Vestrepen, Patrick Van Dijck
MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitochondria. In this study, we identified MGE1 as a multicopy suppressor of susceptibility to the antifungal fluconazole in the model yeast Saccharomyces cerevisiae We demonstrate that this phenomenon is not exclusively dependent on the integrity of the mitochondrial DNA or on the presence of the drug efflux pump Pdr5. Instead, we show that the increased dosage of Mge1 plays a protective role by retaining increased amounts of ergosterol upon fluconazole treatment...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28713826/characterization-of-oral-microbiota-in-removable-dental-prosthesis-users-influence-of-arterial-hypertension
#18
Leila Maria Marchi-Alves, Dayana Freitas, Denise de Andrade, Simone de Godoy, Adrielle Naiara Toneti, Isabel Amélia Costa Mendes
INTRODUCTION: Studies have described the possible relation between oral infections and atherosclerotic events. OBJECTIVE: To characterize the oral microbiota of normotensive and hypertensive users of dental prostheses. METHODS: The sample consisted of 41 complete dental prosthesis users, divided into groups: 21 participants with systemic arterial hypertension and 20 normotensive participants. The data collection included the characteristics of the sociodemographic variables and the determination of the microbial load in the saliva...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28713338/investigation-of-och1-in-the-virulence-of-candida-parapsilosis-using-a-new-neonatal-mouse-model
#19
Katalin Csonka, Máté Vadovics, Annamária Marton, Csaba Vágvölgyi, Erik Zajta, Adél Tóth, Renáta Tóth, Csaba Vizler, László Tiszlavicz, Héctor M Mora-Montes, Attila Gácser
Candida parapsilosis is an opportunistic human fungal pathogen that poses a serious threat to low birth weight neonates, particularly at intensive care units. In premature infants, the distinct immune responses to Candida infections are not well understood. Although several in vivo models exist to study systemic candidiasis, only a few are available to investigate dissemination in newborns. In addition, the majority of related studies apply intraperitoneal infection rather than intravenous inoculation of murine infants that may be less efficient when studying systemic invasion...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712894/antimicrobial-and-immunomodulatory-activity-of-host-defense-peptides-clavanins-and-ll-37-in-vitro-an-endodontic-perspective
#20
Stella Maris F Lima, Mirna S Freire, Ana Luisa O Gomes, Ana Paula C Cantuária, Flávia Rodrigues P Dutra, Beatriz S Magalhães, Maurício Gonçalves C Sousa, Ludovico Migliolo, Jeeser A Almeida, Octávio L Franco, Taia Maria B Rezende
Endodontic treatment is mainly based on root canal disinfection and its failure may be motivated by microbial resistance. Endodontic therapy can be benefitted by host defense peptides (HDPs), which are multifunctional molecules that act against persistent infection and inflammation. This study aimed to evaluate the antimicrobial, cytotoxic and immunomodulatory activity of several HDPs, namely clavanin A, clavanin A modified (MO) and LL-37, compared to intracanal medication Ca(OH)2. HDPs and Ca(OH)2 were evaluated by: (1) antimicrobial assays against Candida albicans and Enterococcus faecalis, (2) cytotoxicity assays and (3) cytokine tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-1α, IL-6, IL-10 and IL-12 and nitric oxide (NO) production by RAW 264...
July 14, 2017: Peptides
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