Lucy C Okell, Titus K Kwambai, Aggrey Dhabangi, Carole Khairallah, Thandile Nkosi-Gondwe, Peter Winskill, Robert Opoka, Andria Mousa, Melf-Jakob Kühl, Tim C D Lucas, Joseph D Challenger, Richard Idro, Daniel J Weiss, Matthew Cairns, Feiko O Ter Kuile, Kamija Phiri, Bjarne Robberstad, Amani Thomas Mori
Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) with dihydroartemisinin-piperaquine reduces this risk. We developed a mathematical model describing the daily incidence of uncomplicated and severe malaria requiring readmission among 0-5-year old children after hospitalised SMA. We fitted the model to a multicentre clinical PDMC trial using Bayesian methods and modelled the potential impact of PDMC across malaria-endemic African countries...
January 25, 2023: Nature Communications