keyword
https://read.qxmd.com/read/38390462/paying-for-parenthood-understanding-parental-leave-policies-in-infectious-disease-fellowship
#1
JOURNAL ARTICLE
Catherine P Gardiner, Laura Desrochers, Kathleen Finn, Furman McDonald, Michael Melia, Michael Melfe, Wendy Stead
BACKGROUND: Many physician trainees plan pregnancy during residency and fellowship. A study of internal medicine program directors (PDs) demonstrated frequent misinterpretation of American Board of Internal Medicine (ABIM) leave policies applied to parental leave. The primary aim was to investigate how infectious disease (ID) PDs interpret current ABIM leave policies. METHODS: We surveyed 155 ID PDs in an online anonymous questionnaire about knowledge of ABIM leave policies and application toward trainee leaves...
February 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38377045/accuracy-of-mri-in-predicting-deep-myometrial-invasion-in-endometrial-cancer-and-the-influence-of-leiomyoma-adenomyosis-and-the-microcystic-elongated-and-fragmented-tumour-pattern
#2
JOURNAL ARTICLE
Anuja Liyanage, Supriya Cardoza, Darshna Kasabia, Helen Moore
INTRODUCTION: The most common form of endometrial cancer is Type 1 endometrioid adenocarcinoma. Depth of myometrial invasion is the most important prognostic factor correlating with overall patient survival. The objective was to investigate how accurate magnetic resonance imaging (MRI) is in predicting the depth of myometrial invasion in preoperative assessment, and the influence of leiomyoma and/or adenomyosis, or microcystic, elongated and fragmented (MELF) pattern of invasion on MRI diagnostic performance...
February 20, 2024: Journal of Medical Imaging and Radiation Oncology
https://read.qxmd.com/read/38052363/outcomes-and-o-d-complex-occupancy-as-a-decision-making-tool-for-surgical-success-in-patients-undergoing-microendoscopic-foraminotomy-for-lumbar-foraminal-stenosis
#3
JOURNAL ARTICLE
Shizumasa Murata, Masanari Takami, Hiroshi Iwasaki, Hiroshi Hashizume, Yasutsugu Yukawa, Akihito Minamide, Yukihiro Nakagawa, Shunji Tsutsui, Motohiro Okada, Keiji Nagata, Yuyu Ishimoto, Masatoshi Teraguchi, Hiroki Iwahashi, Kimihide Murakami, Ryo Taiji, Takuhei Kozaki, Yoji Kitano, Munehito Yoshida, Hiroshi Yamada
OBJECTIVE: To determine the long-term outcomes of microendoscopic foraminotomy (MELF) in treating lumbar foraminal stenosis (LFS) and identify the optimal extent of decompression that yields improved results and fewer complications. METHODS: A retrospective cohort study reviewed the medical records of 95 consecutive patients who underwent MELF for LFS. Clinical outcomes were assessed using the Japanese Orthopedic Association (JOA) scoring system and visual analog scale (VAS) for low back and leg pain...
December 3, 2023: World Neurosurgery
https://read.qxmd.com/read/38002025/endocervical-adenocarcinoma-showing-microcystic-elongated-and-fragmented-melf-pattern-of-stromal-invasion-a-single-institutional-analysis-of-10-cases-with-comprehensive-clinicopathological-analyses-and-ki-67-immunostaining
#4
JOURNAL ARTICLE
Hyunsik Bae, Hyun-Soo Kim
Microcystic, elongated, and fragmented (MELF) pattern of invasion has seldom been documented in endocervical adenocarcinoma (EAC). The aim of this study was to analyze the clinicopathological characteristics of EAC showing MELF pattern. We collected the clinicopathological information of 10 cases of EAC with the MELF pattern and conducted polymer-based immunostaining for Ki-67 (dilution 1:200, clone MIB-1) on these cases. Ki-67 expression was assessed using the average estimation within the hotspot method. All tumors were human papillomavirus-associated EAC with Silva pattern C...
November 11, 2023: Biomedicines
https://read.qxmd.com/read/37806518/microendoscopic-posterior-cervical-laminoforaminotomy-for-c4-radiculopathy
#5
JOURNAL ARTICLE
Daniel Zeitouni, Deborah Pfortmiller, Steve H Monk, Deveney Franklin, David Cowan, Isabel Tenorio, E Hunter Dyer, Mark D Smith, Paul K Kim, Domagoj Coric, Tim E Adamson, Vincent J Rossi
OBJECTIVE: Cervical microendoscopic laminoforaminotomy (MELF) has been proven to be an effective, motion preserving procedure for the surgical treatment of cervical radiculopathy. Cervical four (C4) radiculopathies are often unrecognized by the initial evaluating physician and may be misdiagnosed as axial neck pain. In this study, we compare MELF to anterior cervical disc fusion (ACDF) for C4 radiculopathy in the largest series of minimally invasive foraminotomy for C4 radiculopathy to date...
October 6, 2023: World Neurosurgery
https://read.qxmd.com/read/37733028/molecular-classification-of-endometrial-endometrioid-carcinoma-with-microcystic-elongated-and-fragmented-pattern
#6
JOURNAL ARTICLE
Baohui Ju, Jianghua Wu, Lin Sun, Chunrui Yang, Hu Yu, Quan Hao, Jianmei Wang, Huiying Zhang
The studies on the molecular classification of endometrioid carcinoma (EC) with microcystic, elongated, and fragmented (MELF) pattern invasion are limited. In this study, 77 cases of ECs with MELF patterns in Chinese women were collected. The molecular classification of the fifth edition of the World Health Organization was used to classify the molecular subtypes using immunohistochemistry staining (mismatch repair [MMR]-immunohistochemistry: MSH2, MSH6, MLH1, and PMS2; p53) and Sanger sequencing targeted POLE...
September 8, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/37661323/in-reply
#7
JOURNAL ARTICLE
Constanze Hausteiner-Wiehle, Bettina Böhringer, Matthias Wiehle, Alexandra Melf-Marzi
No abstract text is available yet for this article.
July 10, 2023: Deutsches Ärzteblatt International
https://read.qxmd.com/read/37568650/independent-tissue-based-biomarkers-in-endometrioid-endometrial-cancer-tumor-budding-in-microsatellite-instability-and-who-grading-in-copy-number-low-patients
#8
JOURNAL ARTICLE
Fabian Stögbauer, Barbara Geß, Christine Brambs, Manuela Lautizi, Tim Kacprowski, Iordanis Ourailidis, Holger Bronger, Marion Kiechle, Aurelia Noske, Gisela Keller, Moritz Jesinghaus, Christopher Poremba, Wilko Weichert, Melanie Boxberg
The molecular characterization of endometrial endometrioid adenocarcinomas has provided major advances in its prognostic stratification. However, risk assessment of microsatellite instability (MSI) and copy-number (CN)-low cases remains a challenge. Thus, we aimed to identify tissue-based morphologic biomarkers that might help in the prognostic stratification of these cases. Histomorphologic parameters (WHO grading, tumor budding (TB), tumor-stroma ratio (as a quantitative description of stromal desmoplasia), tumor-infiltrating lymphocytes (TIL), "microcystic, elongated, fragmented" (MELF) pattern) were analyzed in resection specimens of the TCGA-UCEC cohort ( n = 228)...
July 28, 2023: Cancers
https://read.qxmd.com/read/37069595/a-cluster-randomised-trial-to-evaluate-the-effectiveness-of-household-alcohol-based-hand-rub-for-the-prevention-of-sepsis-diarrhoea-and-pneumonia-in-ugandan-infants-the-babygel-trial-a-study-protocol
#9
JOURNAL ARTICLE
Martin Chebet, David Mukunya, Kathy Burgoine, Melf-Jakob Kühl, Duolao Wang, Antonieta Medina-Lara, Eric Brian Faragher, Amos Odiit, Peter Olupot-Olupot, Ingunn Marie Stadskleiv Engebretsen, John Baptist Waniaye, Julius Wandabwa, Thorkild Tylleskär, Andrew Weeks
BACKGROUND: Infections are one of the leading causes of death in the neonatal period. This trial aims to evaluate if the provision of alcohol-based hand rub (ABHR) to pregnant women for postnatal household use prevents severe infections (including sepsis, diarrhoea, pneumonia, or death) among infants during the first three postnatal months. METHODS: Through a cluster-randomised trial in eastern Uganda, 72 clusters are randomised in a 2-arm design with rural villages as units of randomisation...
April 17, 2023: Trials
https://read.qxmd.com/read/37068085/predicting-adherence-to-postdischarge-malaria-chemoprevention-in-malawian-pre-school-children-a-prognostic-multivariable-analysis
#10
JOURNAL ARTICLE
Melf-Jakob Kühl, Thandile Nkosi-Gondwe, Feiko O Ter Kuile, Kamija S Phiri, Mehmajeet Pannu, Mavuto Mukaka, Bjarne Robberstad, Ingunn M S Engebretsen
Chemoprevention with antimalarials is a key strategy for malaria control in sub-Saharan Africa. Three months of postdischarge malaria chemoprevention (PDMC) reduces malaria-related mortality and morbidity in pre-school children recently discharged from hospital following recovery from severe anemia. Research on adherence to preventive antimalarials in children is scarce. We aimed to investigate the predictors for caregivers' adherence to three courses of monthly PDMC in Malawi. We used data from a cluster randomized implementation trial of PDMC in Malawi (n = 357)...
2023: PLOS Glob Public Health
https://read.qxmd.com/read/36697413/projected-health-impact-of-post-discharge-malaria-chemoprevention-among-children-with-severe-malarial-anaemia-in-africa
#11
JOURNAL ARTICLE
Lucy C Okell, Titus K Kwambai, Aggrey Dhabangi, Carole Khairallah, Thandile Nkosi-Gondwe, Peter Winskill, Robert Opoka, Andria Mousa, Melf-Jakob Kühl, Tim C D Lucas, Joseph D Challenger, Richard Idro, Daniel J Weiss, Matthew Cairns, Feiko O Ter Kuile, Kamija Phiri, Bjarne Robberstad, Amani Thomas Mori
Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) with dihydroartemisinin-piperaquine reduces this risk. We developed a mathematical model describing the daily incidence of uncomplicated and severe malaria requiring readmission among 0-5-year old children after hospitalised SMA. We fitted the model to a multicentre clinical PDMC trial using Bayesian methods and modelled the potential impact of PDMC across malaria-endemic African countries...
January 25, 2023: Nature Communications
https://read.qxmd.com/read/36482756/modern-principles-of-diagnosis-and-treatment-in-complex-regional-pain-syndrome
#12
JOURNAL ARTICLE
Alexandra Melf-Marzi, Bettina Böhringer, Matthias Wiehle, Constanze Hausteiner-Wiehle
BACKGROUND: Complex regional pain syndrome (CRPS) is a relatively common complication, occurring in 5% of cases after injury or surgery, particularly in the limbs. The incidence of CPRS is around 5- 26/100 000. The latest revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) now categorizes CRPS as a primary pain condition of multifactorial origin, rather than a disease of the skeletal system or the autonomic nervous system. METHODS: Based on a selective search of the literature, we summarize current principles for the diagnosis and treatment of CRPS...
December 27, 2022: Deutsches Ärzteblatt International
https://read.qxmd.com/read/36473103/solid-phase-synthesis-of-cereblon-recruiting-selective-histone-deacetylase-6-degraders-hdac6-protacs-with-antileukemic-activity
#13
JOURNAL ARTICLE
Laura Sinatra, Jing Yang, Julian Schliehe-Diecks, Niklas Dienstbier, Melina Vogt, Philip Gebing, Luisa M Bachmann, Melf Sönnichsen, Thomas Lenz, Kai Stühler, Andrea Schöler, Arndt Borkhardt, Sanil Bhatia, Finn K Hansen
In this work, we utilized the proteolysis targeting chimera (PROTAC) technology to achieve the chemical knock-down of histone deacetylase 6 (HDAC6). Two series of cereblon-recruiting PROTACs were synthesized via a solid-phase parallel synthesis approach, which allowed the rapid preparation of two HDAC6 degrader mini libraries. The PROTACs were either based on an unselective vorinostat-like HDAC ligand or derived from a selective HDAC6 inhibitor. Notably, both PROTAC series demonstrated selective degradation of HDAC6 in leukemia cell lines...
December 6, 2022: Journal of Medicinal Chemistry
https://read.qxmd.com/read/36422476/is-microcystic-elongated-and-fragmented-pattern-of-myometrial-invasion-in-endometrioid-endometrial-carcinoma-associated-with-survival
#14
JOURNAL ARTICLE
Sultan Deniz Altındağ, Seyran Yiğit, Serhat Şen
BACKGROUND: Microcystic, elongated, and fragmented (MELF) pattern is one of the myometrial invasion patterns in endometrioid endometrial carcinoma (EEC), and it has been associated with poor prognostic parameters, especially lymphovascular space invasion (LVSI) and lymph node metastasis (LNM). This study aims to represent the frequency of MELF pattern in EEC and the relationship between MELF pattern with clinicopathological parameters, overall survival (OS), and disease-free survival (DFS)...
October 2022: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/36351184/development-of-fluorinated-peptoid-based-histone-deacetylase-hdac-inhibitors-for-therapy-resistant-acute-leukemia
#15
JOURNAL ARTICLE
Nina Reßing, Julian Schliehe-Diecks, Paris R Watson, Melf Sönnichsen, Abigail D Cragin, Andrea Schöler, Jing Yang, Linda Schäker-Hübner, Arndt Borkhardt, David W Christianson, Sanil Bhatia, Finn K Hansen
Using a microwave-assisted protocol, we synthesized 16 peptoid-capped HDAC inhibitors (HDACi) with fluorinated linkers and identified two hit compounds. In biochemical and cellular assays, 10h stood out as a potent unselective HDACi with remarkable cytotoxic potential against different therapy-resistant leukemia cell lines. 10h demonstrated prominent antileukemic activity with low cytotoxic activity toward healthy cells. Moreover, 10h exhibited synergistic interactions with the DNA methyltransferase inhibitor decitabine in AML cell lines...
November 9, 2022: Journal of Medicinal Chemistry
https://read.qxmd.com/read/36320878/clinicopathological-prognostic-parameters-of-endometrioid-endometrial-carcinomas
#16
JOURNAL ARTICLE
Ileana Drocaş, Ştefania Crăiţoiu, Alex Emilian Stepan, Ioan Andrei Drocaş, Mioara Desdemona Stepan
Endometrioid endometrial carcinomas (EEC) are common malignant lesions of the female genital tract, with incidence and risk factors that raise issues to improve histopathological prognostic factors. The study included 50 EEC cases, for which the clinicopathological parameters represented by age, risk factors, tumor grade, histological differences, invasion pattern, tumor stage and association of endometrial hyperplasia were analyzed statistically. The results indicated the predominance of EEC in the 7th decade of life, with associated risk factors (78%), more frequently well differentiated (52%), with no other specifications related to differentiation (NOS, 60%), with irregular invasion pattern (66%) in<50% of the myometrial wall (48%)...
April 2022: Current Health Sciences Journal
https://read.qxmd.com/read/36316927/microcystic-elongated-and-fragmented-melf-pattern-in-endometrial-carcinoma-clinicopathologic-analysis-and-prognostic-implications
#17
JOURNAL ARTICLE
Jinghua Song, Huajun Li, Hongyan Guo, Yuhan Cai
To assess the clinical value of microcystic, elongated, and fragmented (MELF) pattern in Chinese patients with endometrial endometrioid carcinoma. A total of 189 patients with endometrial endometrioid carcinoma were retrospectively analyzed in Peking University Third Hospital from January 2017 to December 2019. We analyzed the association of MELF pattern with the histopathologic data and prognosis of the patients, while immunohistochemistry was performed. The frequency of MELF pattern was 17.99% (34/189). MELF pattern was associated significantly with tumor size, myometrial invasion, histological grade, International Federation of Gynecology and Obstetrics stages, lymphovascular space invasion, and lymph node metastasis...
October 28, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36313146/economic-evaluation-of-postdischarge-malaria-chemoprevention-in-preschool-children-treated-for-severe-anaemia-in-malawi-kenya-and-uganda-a-cost-effectiveness-analysis
#18
JOURNAL ARTICLE
Melf-Jakob Kühl, Thandile Gondwe, Aggrey Dhabangi, Titus K Kwambai, Amani T Mori, Robert Opoka, C Chandy John, Richard Idro, Feiko O Ter Kuile, Kamija S Phiri, Bjarne Robberstad
Background: Children hospitalised with severe anaemia in malaria-endemic areas are at a high risk of dying or being readmitted within six months of discharge. A trial in Kenya and Uganda showed that three months of postdischarge malaria chemoprevention (PDMC) with monthly dihydroartemisinin-piperaquine (DP) substantially reduced this risk. The World Health Organization recently included PDMC in its malaria chemoprevention guidelines. We conducted a cost-effectiveness analysis of community-based PDMC delivery (supplying all three PDMC-DP courses to caregivers at discharge to administer at home), facility-based PDMC delivery (monthly dispensing of PDMC-DP at the hospital), and the standard of care (no PDMC)...
October 2022: EClinicalMedicine
https://read.qxmd.com/read/36205778/endometrial-carcinomas-with-dyshesive-eosinophilic-and-vacuolated-histiocyte-like-tumor-cells-a-reactive-like-phenotype-associated-with-aggressive-behavior
#19
JOURNAL ARTICLE
Antonio Travaglino, Damiano Arciuolo, Antonio Raffone, Angela Santoro, Alessia Piermattei, Elena Navarra, Angelo Minucci, Massimo Mascolo, Giulia Scaglione, Nicoletta D'alessandris, Michele Valente, Frediano Inzani, Antonio Mollo, Luigi Insabato, Gian Franco Zannoni
Herein, we present a clinicopathological and molecular analysis of four cases of endometrial carcinoma (EC) diffusely exhibiting dyshesive cells with wide eosinophilic and vacuolated cytoplasm (histiocyte-like tumor cells, HLTCs). We compared these HLTCs to similar cells found in microcystic, elongated and fragmented (MELF) pattern (n = 20) or after neoadjuvant chemotherapy (NAC) (n = 5). The four cases were endometrioid, serous, clear cell, and gastric-type; all were at FIGO stage ≥ III...
March 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/36128689/prognositc-significance-of-microcystic-elongated-and-fragmanted-melf-myometrial-invasion-pattern-a-retrospective-study
#20
JOURNAL ARTICLE
Oguzhan Okcu, Gokce Askan, Bayram Sen, Cigdem Ozturk, Seda Duman Ozturk, Gulname Fındık Guvendi
OBJECTIVE: Endometrioid endometrial carcinomas (EEC) are the most commonly diagnosed malignancies of the female genital tract. Myometrial invasion depth is one of the most significant pathological prognostic parameters. Different morphological invasion patterns have been characterized. This study aimed to investigate the prognostic significance of the microcystic elongated and fragmented (MELF) myometrium invasion pattern in patients with EEC and its relationship with other clinicopathological parameters...
September 21, 2022: Medeniyet medical journal
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