Xiaoxue He, Fan Yang, Yan Wu, Jia Lu, Xiao Gao, Xuerui Zhu, Jie Yang, Shuwen Liu, Gengfu Xiao, Xiaoyan Pan
The cap-snatching mechanism mediated by cap-dependent endonuclease, which is common among the negative-stranded, segmented RNA viruses in Orthomyxoviridae , Bunyaviridae, and Arenaviridae , is crucial for viral transcription and replication and is thus an attractive target for antiviral drug development. Herein, tanshinone I and its analog tanshinone IIA were identified as candidate compounds with broad-spectrum antiviral activities against bandaviruses, including severe fever with thrombocytopenia syndrome virus, Heartland virus, and Guertu virus...
September 21, 2023: Journal of Virology