keyword
https://read.qxmd.com/read/38535505/quantitative-proteomics-reveal-region-specific-alterations-in-neuroserpin-deficient-mouse-brain-and-retina-insights-into-serpini1-function
#21
JOURNAL ARTICLE
Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa, Roshana Vander Wall, Dana Pascovici, Angela Godinez, Giovanna Galliciotti, Joao A Paulo, Veer Gupta, Stuart L Graham, Vivek Gupta, Mehdi Mirzaei
Neural regeneration and neuroprotection represent strategies for future management of neurodegenerative disorders such as Alzheimer's disease (AD) or glaucoma. However, the complex molecular mechanisms that are involved in neuroprotection are not clearly understood. A promising candidate that maintains neuroprotective signaling networks is neuroserpin (Serpini1), a serine protease inhibitor expressed in neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury...
March 14, 2024: Proteomes
https://read.qxmd.com/read/38535502/functional-gastrointestinal-disorders-quality-of-life-and-behaviour-in-adolescents-with-history-of-infant-colic
#22
JOURNAL ARTICLE
Judith Zeevenhooven, Lucas Zeevenhooven, Angela Biesbroek, Renske Schappin, Arine M Vlieger, Bregje E van Sleuwen, Monique P L'Hoir, Marc A Benninga
AIM: To assess the prevalence of functional gastrointestinal disorders (FGIDs), health-related quality of life (HRQOL), and behavioural problems in a cohort of adolescents with a history of infant colic (IC), as defined by Wessel's criteria. METHODS: 388 adolescents, aged 15-18 years, who participated in a randomised controlled trial for infants with colic, were invited for our observational follow-up study. Prevalence of FGIDs was assessed with the Rome IV Questionnaire on Paediatric Gastrointestinal Disorders (RIV-QPGD), HRQOL through self-report of the Paediatric Quality of Life Inventory (PedsQL), and behavioural problems through parent-report of the child behaviour checklist (CBCL)...
March 27, 2024: Acta Paediatrica
https://read.qxmd.com/read/38535500/an-exploratory-investigation-of-organic-chemicals-detected-in-baby-teeth-differences-in-children-with-and-without-autism
#23
JOURNAL ARTICLE
Raymond F Palmer
Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by deficits in language, communication, and social function with an estimated prevalence rate of between 1 in 30 and 44 U.S. births. Gene/environment (G × E) interactions are widely regarded as the most probable explanation for idiopathic ASD, especially because some genes are selectively targeted by various environmental xenobiotics. Because deciduous teeth are a likely biomarker of in utero exposure, the present study investigated if the quantity of chemicals found in deciduous teeth differs between children with and without ASD...
March 14, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535420/functional-recovery-and-regenerative-effects-of-direct-transcutaneous-electrical-nerve-stimulation-in-treatment-of-post-covid-19-guillain-barr%C3%A3-and-acute-transverse-myelitis-overlap-syndrome-a-clinical-case
#24
Mustafa Al-Zamil, Natalia G Kulikova, Inessa A Minenko, Numman Mansur, Denis M Zalozhnev, Marat B Uzdenov, Alina A Dzhanibekova, Alikhan A Gochiyayev, Natalia A Shnayder
Transcutaneous electrical nerve stimulation (TENS) has proven effective in treating pain in many experimental and clinical studies. In addition to the analgesic effect, direct TENS of peripheral nerves had anti-inflammatory and regenerative effects in the treatment of distal polyneuropathy and spinal cord injury. This work demonstrates the experience of using direct TENS in the treatment of a 52-year-old patient with post-COVID-19 Guillain-Barré (GBS) and acute transverse myelitis (ATM) overlap syndrome...
February 26, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535311/in-vitro-astroglial-dysfunction-induced-by-neurotoxins-mimicking-astrocytic-metabolic-alterations-of-alzheimer-s-disease
#25
JOURNAL ARTICLE
Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leite
Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100B, in addition to alterations in some of its metabolic functions. To understand the role of astrocytes in neurodegeneration mechanisms, we induced some of these metabolic alterations, such as energy metabolism, using methylglyoxal (MG) or fluorocitrate (FC); and neuroinflammation, using lipopolysaccharide (LPS) and streptozotocin (STZ), which is used for inducing Alzheimer's disease (AD) in animal models...
March 1, 2024: Metabolites
https://read.qxmd.com/read/38535293/integrative-analysis-of-cytokine-and-lipidomics-datasets-following-mild-traumatic-brain-injury-in-rats
#26
JOURNAL ARTICLE
Alexis N Pulliam, Alyssa F Pybus, David A Gaul, Samuel G Moore, Levi B Wood, Facundo M Fernández, Michelle C LaPlaca
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI is characterized by complex secondary cascades that involve altered homeostasis and metabolism, faulty signaling, neuroinflammation, and lipid dysfunction. The objectives of the present study were to (1) assess potential correlations between lipidome and cytokine changes after closed-head mild TBI (mTBI), and (2) examine the reproducibility of our acute lipidomic profiles following TBI...
February 21, 2024: Metabolites
https://read.qxmd.com/read/38535207/a-novel-carmil2-immunodeficiency-identified-in-a-subset-of-cavalier-king-charles-spaniels-with-pneumocystis-and-bordetella-pneumonia
#27
JOURNAL ARTICLE
Emily L Coffey, Liang Ma, Ousmane H Cissé, Joseph A Kovacs, Katie M Minor, Antti Sukura, Patrizia Danesi, Steven G Friedenberg, Jonah N Cullen, Christiane Weissenbacher-Lang, Julie C Nadeau, Amber M Graham, Martin N Granick, Natalie K Branson, Kyle C Branson, Barbara Blasi, Casandra M Jacobs, Eva Furrow
Pet dogs are a valuable natural animal model for studying relationships between primary immunodeficiencies and susceptibility to Pneumocystis and other opportunistic respiratory pathogens. Certain breeds, such as the Cavalier King Charles Spaniel, are over-represented for Pneumocystis pneumonia (PCP), suggesting the presence of a primary immunodeficiency in the breed. Here, we report the discovery of a CARMIL2 nonsense variant in three Cavalier King Charles Spaniel dogs with either PCP (n = 2) or refractory Bordetella pneumonia (n = 1)...
March 5, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535081/the-contribution-of-functional-near-infrared-spectroscopy-fnirs-to-the-study-of-neurodegenerative-disorders-a-narrative-review
#28
REVIEW
Ioannis Liampas, Freideriki Danga, Panagiota Kyriakoulopoulou, Vasileios Siokas, Polyxeni Stamati, Lambros Messinis, Efthimios Dardiotis, Grigorios Nasios
Functional near-infrared spectroscopy (fNIRS) is an innovative neuroimaging method that offers several advantages over other commonly used modalities. This narrative review investigated the potential contribution of this method to the study of neurodegenerative disorders. Thirty-four studies involving patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), frontotemporal dementia (FTD), Parkinson's disease (PD), or amyotrophic lateral sclerosis (ALS) and healthy controls were reviewed. Overall, it was revealed that the prefrontal cortex of individuals with MCI may engage compensatory mechanisms to support declining brain functions...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535069/correlation-between-structural-and-functional-changes-in-patients-with-raised-intraocular-pressure-due-to-graves-orbitopathy
#29
JOURNAL ARTICLE
Freja Bagatin, Ante Prpić, Jelena Škunca Herman, Ognjen Zrinšćak, Renata Iveković, Zoran Vatavuk
This study explores the complication of secondary intraocular pressure (IOP) elevation and consequent glaucoma development in Graves' orbitopathy (GO), an autoimmune disorder associated with hyperthyroidism. Utilizing Octopus 900 visual field testing and optical coherence tomography (OCT), the research established correlations between functional and structural changes in optic nerve regions in patients with GO and patients with GO with elevated IOP (GO IOP) groups. A comparison with primary open-angle glaucoma (POAG) was conducted in a cohort of 182 subjects...
March 20, 2024: Diagnostics
https://read.qxmd.com/read/38535006/current-trends-and-applications-of-pet-mri-hybrid-imaging-in-neurodegenerative-diseases-and-normal-aging
#30
REVIEW
Jonathan Lee, Jonathan Renslo, Kasen Wong, Thomas G Clifford, Bryce D Beutler, Paul E Kim, Ali Gholamrezanezhad
Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers...
March 10, 2024: Diagnostics
https://read.qxmd.com/read/38534993/clinical-and-mri-based-assessment-of-patients-with-temporomandibular-disorders-treated-by-controlled-mandibular-repositioning
#31
JOURNAL ARTICLE
Diwakar Singh, Alain Landry, Martina Schmid-Schwap, Eva Piehslinger, André Gahleitner, Jiang Chen, Xiaohui Rausch-Fan
BACKGROUND: Occlusal splints and anterior repositioning splints (ARSs) are widely accepted treatments for temporomandibular disorders (TMDs). However, there is uncertainty with regard to the most suitable amount of mandibular repositioning. The aim of this study is to evaluate the clinical and functional effects of the therapeutic position (ThP) established based on the Controlled Mandibular Repositioning (CMR) method. METHODS: In this clinical trial, 20 subjects with 37 joints with disc displacement with reduction were recruited...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534968/clinical-practice-guidelines-for-the-diagnosis-and-management-of-hereditary-fructose-intolerance
#32
JOURNAL ARTICLE
Félix Úbeda, Sonia Santander, María José Luesma
INTRODUCTION: Hereditary fructose intolerance or hereditary fructosemia is an autosomal recessive metabolic disorder caused by a loss of function in the aldolase B gene. This disorder affects 1 in 20,000 people, constituting a rare disease with a favorable prognosis through adherence to a fructose-free diet. Despite dietary management, chronic pathology may manifest, underscoring the importance of early diagnosis to mitigate adverse effects. However, early detection of the disease poses significant challenges...
February 23, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534851/knee-measurement-system-with-osteoarthritis-levels-using-artificial-cartilage-and-skeletons
#33
JOURNAL ARTICLE
Minchae Kang, Suyeon Seo, Hyewon Lee, Min-Woo Han
Knee osteoarthritis (OA), also known as degenerative arthritis, is a disease characterized by irreversible changes in the cartilage and bones comprising the joints, resulting in pain, impaired function, and deformity. Furthermore, independent of natural aging, the rate of change in joint cartilage has increased in recent years, which is mainly attributed to environmental factors. The rising incidence of knee-related disorders emphasizes the importance of analyzing the morphology and kinematics of knee structure...
March 8, 2024: Biomimetics
https://read.qxmd.com/read/38534804/cannabis-use-and-its-impact-on-mental-health-in-youth-in-australia-and-the-united-states-a-scoping-review
#34
REVIEW
Aayush Baral, Fahad Hanna, Ritesh Chimoriya, Kritika Rana
Cannabis is a widely used substance among the youth population, with an estimated 2.8% currently smoking cannabis. Its popularity is growing due to the perception of its harmless nature and lack of dependence. However, this increase in use has been linked to mental health issues, especially since its partial decriminalisation in some part of the United States and Australia. The objective of this scoping review was to investigate the mental health impact of cannabis use among young people in Australia and the United States...
February 29, 2024: Epidemiologia (Basel)
https://read.qxmd.com/read/38534785/cellular-organelle-related-transcriptomic-profile-abnormalities-in-neuronopathic-types-of-mucopolysaccharidosis-a-comparison-with-other-neurodegenerative-diseases
#35
JOURNAL ARTICLE
Karolina Wiśniewska, Lidia Gaffke, Magdalena Żabińska, Grzegorz Węgrzyn, Karolina Pierzynowska
Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) degradation. As a result, GAGs accumulate in lysosomes, impairing the proper functioning of entire cells and tissues. There are 14 types/subtypes of MPS, which are differentiated by the kind(s) of accumulated GAG(s) and the type of a non-functional lysosomal enzyme. Some of these types (severe forms of MPS types I and II, MPS III, and MPS VII) are characterized by extensive central nervous system disorders...
March 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534735/microbial-based-bioactive-compounds-to-alleviate-inflammation-in-obesity
#36
REVIEW
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534724/relationship-between-androgens-and-vascular-and-placental-function-during-pre-eclampsia
#37
REVIEW
Lara M Fernandes, Margarida Lorigo, Elisa Cairrao
Hypertensive disorders of pregnancy (HDP) represent a substantial risk to maternal and fetal health. Emerging evidence suggests an association between testosterone and pre-eclampsia (PE), potentially mediated through androgen receptors (AR). Nevertheless, the mechanism driving this association is yet to be elucidated. On the other hand, reports of transgender men's pregnancies offer a limited and insightful opportunity to understand the role of high androgen levels in the development of HDP. In this sense, a literature review was performed from a little over 2 decades (1998-2022) to address the association of testosterone levels with the development of HDP...
February 21, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534723/the-role-of-aminopeptidase-erap1-in-human-pathology-a-review
#38
REVIEW
Laura Țiburcă, Dana Carmen Zaha, Maria Claudia Jurca, Emilia Severin, Aurora Jurca, Alexandru Daniel Jurca
Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic reticulum aminopeptidase 2), and LNPEP (coding for leucyl and cystinyl aminopeptidase). These genes encoding these enzymes are contiguous and located on the same chromosome (5q21); they share structural homology and functions and are associated with immune-mediated diseases...
February 20, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534545/applications-of-imaging-technologies-in-fuchs-endothelial-corneal-dystrophy-a-narrative-literature-review
#39
REVIEW
Sang Beom Han, Yu-Chi Liu, Chang Liu, Jodhbir S Mehta
Fuchs endothelial corneal dystrophy (FECD) is a complex genetic disorder characterized by the slow and progressive degeneration of corneal endothelial cells. Thus, it may result in corneal endothelial decompensation and irreversible corneal edema. Moreover, FECD is associated with alterations in all corneal layers, such as thickening of the Descemet membrane, stromal scarring, subepithelial fibrosis, and the formation of epithelial bullae. Hence, anterior segment imaging devices that enable precise measurement of functional and anatomical changes in the cornea are essential for the management of FECD...
March 11, 2024: Bioengineering
https://read.qxmd.com/read/38534521/does-liquid-injectable-platelet-rich-fibrin-help-in-the-arthrocentesis-treatment-of-temporomandibular-joint-disorder-compared-to-other-infusion-options-a-systematic-review-of-randomized-clinical-trials
#40
REVIEW
Alexander Nemeth, Bruno Vasconcelos Gurgel, Adam Lowenstein, Luiz Juliasse, Rafael S Siroma, Zoe Zhu, Jamil Awad Shibli, Carlos Fernando Mourão
Temporomandibular joint disorders (TMDs) are prevalent musculoskeletal conditions involving pain and dysfunction of jaw mobility and function, which have proven difficult to treat satisfactorily. The present study aimed to assess the effectiveness of a liquid platelet-rich fibrin (i-PRF) infusion during arthrocentesis versus other options using coadjuvant materials to reduce TMD symptoms. A literature search was conducted using PubMed, EMBASE, Web of Science, Scopus, and ClinicalTrials.gov for RCTs published before January 2024, comparing i-PRF to any other TMD treatment...
March 2, 2024: Bioengineering
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