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https://www.readbyqxmd.com/read/29245178/transcriptional-regulation-of-cd4-t-cell-differentiation-in-experimentally-induced-arthritis-and-rheumatoid-arthritis
#1
REVIEW
Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by infiltration of the joint synovium by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathological process. In general, CD4+ T cells differentiate into various T helper (Th) cell subsets and acquire the functional characterization to respond to specific pathogens, and also mediated some autoimmune disorders such as RA. Because the differentiation of Th cell subsets is determined by the expression of specific transcription factors in response to cytokine environment, these transcription factors is considered to have a role in pathology of RA...
December 15, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29245125/delayed-type-hypersensitivity-to-metals-in-connective-tissue-diseases-and-fibromyalgia
#2
REVIEW
Geir Bjørklund, Maryam Dadar, Jan Aaseth
Rheumatic diseases include a group of autoimmune disorders with environmental and genetic etiology that are characterized as a subgroup of connective tissue diseases (CTD). Rheumatoid arthritis (RA) often involves the small joints of the hands in a symmetrical fashion that can lead to loss of joint function, and RA, as well as Sjögren's syndrome (SS) and other rheumatic diseases, are often accompanied by sensitivity to metals. Numerous investigations on metal sensitivity were evaluated in this review. A detailed metal exposure history was collected by different evaluation of studies...
December 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/29245099/total-bilateral-tmj-reconstruction-for-pain-and-dysfunction-case-report
#3
Carlos Vinícius Ayres Moreira, André Victor Pinto Serra, Larissa Oliveira Ramos Silva, Ana Carolina Fraga Fernandes, Roberto Almeida de Azevedo
INTRODUCTION: Temporomandibular disorders encompass a set of clinical conditions that affect the temporomandibular joint, the masticatory muscles and the associated tissues. Many therapeutic alternatives can be considered, being divided into non-invasive, minimally invasive and invasive interventions. This work aims to report a case of inflammatory joint pain and dysfunction treated with bilateral TMJ full reconstruction with alloplastic prosthesis stock. CASE REPORT: Patient D...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245093/neurocognitive-functioning-in-first-episode-bipolar-disorder-relationship-with-functional-status
#4
Alejandro G Szmulewicz, Marina P Valerio, Julieta Lomastro, José M Smith, Virginia Chiappe, Diego J Martino, Ana Igoa
BACKGROUND: The aim of this study was to assess if an association between neurocognitive deficits and psychosocial functioning exists in first-episode BD patients. METHODS: Twenty-five euthymic first-episode BD patients and thirty-seven healthy controls were recruited. History of suicide attempts, psychiatric comorbidities, pharmacological exposure, and previous depressive episodes were investigated. Performances on neurocognitive domains (verbal memory, attention, processing speed, and executive functions) as well as a measure of psychosocial functioning were used as outcomes...
December 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29245045/relations-between-problem-behaviors-perceived-symptom-severity-and-parenting-in-adolescents-and-emerging-adults-with-asd-the-mediating-role-of-parental-psychological-need-frustration
#5
Lisa M Dieleman, Sarah S W De Pauw, Bart Soenens, Elien Mabbe, Rachel Campbell, Peter Prinzie
Research in parents of youngsters with Autism Spectrum Disorder (ASD) increasingly documents associations between children's problem behaviors and symptom severity and more dysfunctional and less adaptive parenting behaviors. However, the mechanisms underlying these associations have not been examined thoroughly. This study examines the mediating role of parental need frustration in the relation between child maladjustment (i.e., problem behavior and autism severity) and parenting behavior (i.e., controlling and autonomy-supportive parenting)...
December 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29244957/hypercementosis-associated-with-enpp1-mutations-and-gaci
#6
V Thumbigere-Math, A Alqadi, N I Chalmers, M B Chavez, E Y Chu, M T Collins, C R Ferreira, K FitzGerald, R I Gafni, W A Gahl, K S Hsu, M S Ramnitz, M J Somerman, S G Ziegler, B L Foster
Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi). Three regulators that control pericellular concentrations of Pi and PPi include tissue-nonspecific alkaline phosphatase (TNAP), progressive ankylosis protein (ANK), and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). Inactivation of these factors results in mineralization disorders affecting teeth and their supporting structures. This study for the first time analyzed the effect of decreased PPi on dental development in individuals with generalized arterial calcification of infancy (GACI) due to loss-of-function mutations in the ENPP1 gene...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29244892/alterations-in-the-masticatory-system-in-patients-with-amyotrophic-lateral-sclerosis
#7
Nina Riera-Punet, Jordi Martinez-Gomis, Andrés Paipa, Monica Povedano, Maria Peraire
AIMS: To determine the effect of amyotrophic lateral sclerosis (ALS) on aspects of masticatory function and to assess the relationship between ALS and the prevalence of traumatic mucosal lesions caused by oral self-injury. METHODS: A total of 153 ALS patients and 23 control subjects participated in this cross-sectional study. Clinical characteristics including site of onset, medication, type of feeding, and use of noninvasive mechanical ventilation were recorded...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#8
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29244747/ophthalmic-formulation-containing-nilvadipine-nanoparticles-prevents-retinal-dysfunction-in-rats-injected-with-streptozotocin
#9
Saori Deguchi, Hiroko Otake, Yosuke Nakazawa, Noriko Hiramatsu, Naoki Yamamoto, Noriaki Nagai
Retinopathy leads to irreparable vision loss via capillary closure and areas of nonperfusion. However, the current instillation systems do not allow a sufficient amount of drug required to treat retinopathy to reach the posterior segment (retina); therefore, a new formulation targeting the posterior segment is expected as therapy for retinopathy. We prepared ophthalmic formulations containing nilvadipine nanoparticles (NILnano), and demonstrated whether the instillation of NILnano can prevent retinal dysfunction in rats injected with excessive streptozotocin (STZ rats) in this study...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244250/human-innate-lymphoid-cells-ilcs-towards-a-uniform-immune-phenotyping
#10
REVIEW
Sara Trabanelli, Alejandra Gomez Cadena, Domenico Mavilio, Basile Nicolas Landis, Peter Jandus, Camilla Jandus
Helper Innate Lymphoid Cells (ILCs), the most recently identified population of the Innate Lymphoid Cell family, plays a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2 and ILC3, that can be specifically activated by different signals coming either from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions...
December 15, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/29244071/the-glycosyltransferase-eogt-regulates-adropin-expression-in-decidualizing-human-endometrium
#11
Joanne Muter, Mohammad T Alam, Pavle Vrljicak, Flavio S V Barros, Peter T Ruane, Lauren J Ewington, John D Aplin, Melissa Westwood, Jan J Brosens
In pregnancy, resistance of endometrial decidual cells to stress signals is critical for the integrity of the feto-maternal interface and, by extension, survival of the conceptus. O-GlcNAcylation is an essential post-translational modification that links glucose sensing to cellular stress resistance. Unexpectedly, decidualization of primary endometrial stromal cells (EnSCs) was associated with a 60% reduction in O-GlcNAc modified proteins, reflecting downregulation of the enzyme that adds O-GlcNAc to substrates (O-GlcNAc transferase, OGT) but not the enzyme that removes the modification (O-GlcNAcase, OGA)...
December 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29243873/a-comprehensive-review-of-genetic-and-epigenetic-mechanisms-that-regulate-bdnf-expression-and-function-with-relevance-to-major-depressive-disorder
#12
REVIEW
Benjamin Hing, Leela Sathyaputri, James B Potash
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs cognition. A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, subcellular localization, and sorting to appropriate secretory pathways. Alterations to these processes by genetic factors and negative stressors can dysregulate its expression, with possible implications for MDD...
December 15, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29243770/adipose-derived-stem-cells-in-articular-cartilage-regeneration-current-concepts-and-optimization-strategies
#13
REVIEW
Xingjian Gu, Caixin Li, Feng Yin, Guanghua Yang
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration...
December 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29243349/autosomal-recessive-primary-microcephaly-due-to-aspm-mutations-an-update
#14
Pascaline Létard, Séverine Drunat, Yoann Vial, Sarah Duerinckx, Anais Ernault, Daniel Amram, Stéphanie Arpin, Marta Bertoli, Tiffany Busa, Berten Ceulemans, Julie Desir, Martine Doco-Fenzy, Siham Chafai Elalaoui, Koenraad Devriendt, Laurence Faivre, Christine Francannet, David Geneviève, Marion Gérard, Cyril Gitiaux, Sophie Julia, Sébastien Lebon, Toni Lubala, Michèle Mathieu-Dramard, Hélène Maurey, Julia Metreau, Sanaa Nasserereddine, Mathilde Nizon, Geneviève Pierquin, Nathalie Pouvreau, Clothilde Rivier-Ringenbach, Massimiliano Rossi, Elise Schaefer, Abdelaziz Sefiani, Sabine Sigaudy, Yves Sznajer, Yusuf Tunca, Sophie Guilmin Crepon, Corinne Alberti, Monique Elmaleh-Bergès, Brigitte Benzacken, Bernd Wollnick, C Geoffrey Woods, Anita Rauch, Marc Abramowicz, Vincent El Ghouzzi, Pierre Gressens, Alain Verloes, Sandrine Passemard
Autosomal recessive microcephaly or MicroCephaly Primary Hereditary (MCPH) is a genetically heterogeneous neurodevelopmental disorder characterized by a reduction in brain volume, indirectly measured by an occipitofrontal circumference (OFC) 2 standard deviations or more below the age- and sex-matched mean (-2SD) at birth and -3SD after 6 months, and leading to intellectual disability of variable severity. The Abnormal SPindle-like Microcephaly gene (ASPM), the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), encodes ASPM, a protein localized at the centrosome of apical neuroprogenitor cells and involved in spindle pole positioning during neurogenesis...
December 14, 2017: Human Mutation
https://www.readbyqxmd.com/read/29243228/mitochondria-and-redox-balance-in-celiac-disease-a-case-control-study
#15
A Picca, G Riezzo, A M S Lezza, C Clemente, V Pesce, A Orlando, G Chimienti, F Russo
BACKGROUND: Celiac disease (CD) is a gluten-sensitive autoimmune disorder. Gluten toxicity encompasses a wide spectrum of target organ functions and pathologies, including the activation of the immune response and triggering of oxidative stress. The aim of this study was to investigate inflammation and the redox balance in patients with active CD, and to evaluate whether alteration of mitochondrial function is involved in the disease status. DESIGN: In this prospective case-control study, blood samples from sixteen adult CD patients and sixteen healthy controls (HC) were investigated for IL-1β, IL-6, and IL-8 plasma concentrations, for serum PON1 arylesterase, total and MnSOD antioxidant enzymes activities, induced TBARs levels, and for lymphocyte mtDNA content...
December 15, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29243182/the-facial-nerve-anatomy-and-associated-disorders-for-oral-health-professionals
#16
Kojiro Takezawa, Grant Townsend, Mounir Ghabriel
The facial nerve, the seventh cranial nerve, is of great clinical significance to oral health professionals. Most published literature either addresses the central connections of the nerve or its peripheral distribution but few integrate both of these components and also highlight the main disorders affecting the nerve that have clinical implications in dentistry. The aim of the current study is to provide a comprehensive description of the facial nerve. Multiple aspects of the facial nerve are discussed and integrated, including its neuroanatomy, functional anatomy, gross anatomy, clinical problems that may involve the nerve, and the use of detailed anatomical knowledge in the diagnosis of the site of facial nerve lesion in clinical neurology...
December 14, 2017: Odontology
https://www.readbyqxmd.com/read/29243158/bilateral-native-nephrectomy-to-reduce-oxalate-stores-in-children-at-the-time-of-combined-liver-kidney-transplantation-for-primary-hyperoxaluria-type-1
#17
Eliza Lee, Gabriel Ramos-Gonzalez, Nancy Rodig, Scott Elisofon, Khashayar Vakili, Heung Bae Kim
OBJECTIVE: Primary hyperoxaluria type-1 (PH-1) is a rare genetic disorder in which normal hepatic metabolism of glyoxylate is disrupted resulting in diffuse oxalate deposition and end-stage renal disease (ESRD). While most centers agree that combined liver-kidney transplant (CLKT) is the appropriate treatment for PH-1, perioperative strategies for minimizing recurrent oxalate-related injury to the transplanted kidney remain unclear. We present our management of children with PH-1 and ESRD on hemodialysis (HD) who underwent CLKT at our institution from 2005 to 2015...
December 14, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29243122/aberrant-baseline-brain-activity-in-psychogenic-erectile-dysfunction-patients-a-resting-state-fmri-study
#18
Chenwang Jin, Min Guan, Minghao Dong, Jia Wu, Zhen He, Xin Chen, Dapeng Shi, Junchan Ren, Guangming Shi, Xiangsheng Zhang
Recent neuroimaging studies have elucidated many interesting and promising findings on sexuality regarding the neural underpinnings of both normal and abnormal sexual processes. Psychogenic erectile dysfunction (pED) consists of a major part of male sexual dysfunction in China, but the understanding of the central mechanism of pED is still in its infancy. It is commonly appreciated that pED is a functional disorder, which can be attributed predominantly or exclusively to psychological factors, such as anxiety, depression, loss of self-esteem, and psychosocial stresses...
December 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29242992/dynamic-adaptation-in-neurosteroid-networks-in-response-to-alcohol
#19
Deborah A Finn, Vanessa A Jimenez
The term neurosteroid refers to rapid membrane actions of steroid hormones and their derivatives that can modulate physiological functions and behavior via their interactions with ligand-gated ion channels. This chapter will highlight recent advances pertaining to the modulatory effects of a select group of neurosteroids that are primarily potent positive allosteric modulators of γ-aminobutyric acidA receptors (GABAARs). Nanomolar concentrations of neurosteroids, which occur in vivo, potentiate phasic and tonic forms of GABAAR-mediated inhibition, indicating that both synaptic and extrasynaptic GABAARs possess sensitivity to neurosteroids and contribute to the overall ability of neurosteroids to modulate central nervous system excitability...
December 15, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29242950/superior-canal-dehiscence-syndrome-diagnosis-with-vestibular-evoked-myogenic-potentials-and-fremitus-nystagmus
#20
R Gürkov, C Jerin, W Flatz, R Maxwell
BACKGROUND: Superior canal dehiscence syndrome (SCDS) is a relatively rare neurotological disorder that is characterized by a heterogeneous clinical picture. Recently, vestibular evoked myogenic potential (VEMP) measurement was established for the diagnosis of SCDS. In the present study, a case series of patients with SCDS were analyzed, with a focus on VEMP. METHODS: Four patients with SCDS were prospectively examined with ocular VEMP (oVEMP) and cervical VEMP (cVEMP)...
December 14, 2017: HNO
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