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vitamin d dose

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https://www.readbyqxmd.com/read/28092390/asthma-comparing-the-impact-of-vitamin-d-versus-uvr-on-clinical-and-immune-parameters
#1
Kylie A Morgan, Elizabeth H Mann, Antony R Young, Catherine M Hawrylowicz
The incidence of asthma has increased markedly since the 1960s and is currently estimated to affect more than 300 million individuals worldwide. A number of environmental factors are implicated in asthma pathogenesis, one of which is vitamin D. Vitamin D deficiency is a global health concern and has increased in parallel with asthma incidence. Epidemiological studies report associations between low vitamin D status, assessed as circulating levels of 25-hydroxyvitamin D, with asthma incidence, severity, exacerbations and responses to treatment...
January 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28088363/seasonal-variations-of-u-s-mortality-rates-roles-of-solar-ultraviolet-b-doses-vitamin-d-gene-exp-ression-and-infections
#2
REVIEW
William B Grant, Harjit Pal Bhattoa, Barbara J Boucher
Death rates in the U.S. show a pronounced seasonality. The broad seasonal variation shows about 25% higher death rates in winter than in summer with an additional few percent increase associated with the Christmas and New Year's holidays. A pronounced increase in death rates also starts in mid-September, shortly after the school year begins. The causes of death with large contributions to the observed seasonality include diseases of the circulatory system; the respiratory system; the digestive system; and endocrine, nutritional, and metabolic diseases...
January 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28079136/snp-rs11185644-of-rxra-gene-is-identified-for-dose-response-variability-to-vitamin-d3-supplementation-a-randomized-clinical-trial
#3
Mingzhi Zhang, Lan-Juan Zhao, Yu Zhou, Rhamee Badr, Patrice Watson, An Ye, Boting Zhou, Jigang Zhang, Hong-Wen Deng, Robert R Recker, Joan M Lappe
The level of serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to variations in serum 25(OH)D level and vitamin D dose-response. As vitamin D deficiency has been linked to numerous diseases, understanding how genetic variation contributes to vitamin D dose-response is important for personalized vitamin D treatment and cost-effective disease prevention. To identify genetic variants responsible for vitamin D status and dose-response, we performed two vitamin D3 and calcium clinical supplementation trials in 2,207 postmenopausal Caucasian women...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077342/can-stoss-therapy-be-used-in-children-with-vitamin-d-deficiency-or-insufficiency-without-rickets
#4
Cemil Koçyiğit, Gönül Çatlı, Gülberat İnce, Elif Büşra Özkan, Bumin Nuri Dündar
OBJECTIVE: Stoss treatment has also been suggested due to non-skeletal benefits of vitamin D in adults, but no sufficient data are present about the optimal dose of vitamin D replacement in children with vitamin D deficiency/insufficiency without rickets. This study aimed to compare efficiency/side effects of two different stoss therapy regimens (10.000 IU/kg and 300.000 IU vitamin-D3) administered in children with vitamin D deficiency/insufficiency without rickets. METHODS: Sixty-four children who had vitamin-D deficiency/insufficiency were studied...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28074679/vitamin-d-treatment-improves-levels-of-sexual-hormones-metabolic-parameters-and-erectile-function-in-middle-aged-vitamin-d-deficient-men
#5
Onder Canguven, Raidh A Talib, Walid El Ansari, Dany-Jan Yassin, Abdullah Al Naimi
BACKGROUND: The associations between serum vitamin D (VD), serum testosterone (TT) and metabolic syndrome are complex and with limited published research, particularly on the effects of VD treatment on sexual hormones, erectile function and the metabolic syndrome. OBJECTIVES: This study assessed whether a monthly high dose VD treatment for 12 months in VD deficient middle-aged men was associated with: changes in levels of sexual hormones, improvement of diabetes control and metabolic syndrome components, better erectile function [International Index of Erectile Function (IIEF)-5 questionnaire]; and changes in a prostate marker...
January 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28068529/impact-of-high-dose-statins-on-vitamin-d-levels-and-platelet-function-in-patients-with-coronary-artery-disease
#6
Monica Verdoia, Patrizia Pergolini, Roberta Rolla, Matteo Nardin, Alon Schaffer, Lucia Barbieri, Veronica Daffara, Paolo Marino, Giorgio Bellomo, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Statins represent a pivotal treatment in coronary artery disease, offering a reduction in cardiovascular risk even beyond their lipid-lowering action. However, the mechanism of these "pleiotropic" benefits of statins is poorly understood. Vitamin D has been suggested as a potential mediator of the anti-inflammatory, anti-thrombotic and vascular protecting effects of statins. Aim of present study was to assess the impact of a high-intensity statin therapy on vitamin D levels and platelet function in patients with coronary artery disease...
December 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28065758/vitamin-e-reduces-endosulfan-induced-toxic-effects-on-morphology-and-behavior-in-early-development-of-zebrafish-danio-rerio
#7
K Dale, J D Rasinger, K L Thorstensen, S Penglase, S Ellingsen
The aim of this study was to investigate if vitamin E (α-TOC) modulates the developmental toxicity of the pesticide endosulfan (ESF), using a modified zebrafish embryotoxicity test (ZET). Zebrafish (Danio rerio) embryos were exposed from 6 to 72 h post fertilization (hpf) to either ESF (0.1-50 mg/L) or α-TOC (0.01-3 mM) alone or in combination. The effects of these exposures on embryonic morphology, larval behavior and antioxidant gene expression were analyzed. Phenotypic analysis at 48 hpf showed that ESF led to a dose-dependent increase in embryonic deformities, including axis malformations, pericardial edema and reduced pigmentation...
January 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28065420/effectiveness-of-dietary-supplements-in-spinal-cord-injury-subjects
#8
REVIEW
Angela Navarrete-Opazo, Pilar Cuitiño, Inés Salas
BACKGROUND: Individuals with spinal cord injury (SCI) consume more dietary supplements than the general population. However, there is limited information regarding the clinical effectiveness of dietary supplements in SCI population. OBJECTIVE: To systematically review the effectiveness of dietary supplements for the prevention or treatment of health-related conditions associated with SCI. METHODS: Randomized or non-randomized controlled clinical trials were selected, comparing the effect of any dose and form of a dietary supplement (defined by the Dietary Supplement Health and Education Act), with either no treatment, placebo, or other medication...
December 19, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/28063517/the-increasing-problem-of-subclinical-and-overt-hypervitaminosis-d-in-india-an-institutional-experience-and-review
#9
Lokesh Kumar Sharma, Deep Dutta, Neera Sharma, Adesh Kisanji Gadpayle
OBJECTIVE: The aim of this study was to determine the changes in serum vitamin D distribution at an institute in India over the past 6 y and compare it with global trends. METHODS: We conducted an audit of 25-hydroxyvitamin D (25-OHD), calcium, and plasma intact parathyroid hormone (iPTH) reporting from January 2011 to February 2016. References for review were identified through searches of PubMed, Medline, and Embase for articles published until February 2016 using keywords "hypervitaminosis D" (MeSH Terms) OR "vitamin D toxicity" (All Fields) OR "vitamin-D intoxication" (All Fields)...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28054941/effects-of-chronic-vitamin-d%C3%A2-hormone-administration-on-anxiety-like-behavior-in-adult-female-rats-after-long-term-ovariectomy
#10
Julia Fedotova, Svetlana Pivina, Anastasia Sushko
The present preclinical study was created to determine the therapeutic effects of vitamin D hormone treatment as an adjunctive therapy alone or in a combination with low dose of 17β-estradiol (17β-E₂) on anxiety-like behavior in female rats with long-term absence of estrogen. Accordingly, the aim of the current study was to examine the effects of chronic cholecalciferol administration (1.0, 2.5 or 5.0 mg/kg subcutaneously, SC, once daily, for 14 days) on the anxiety-like state after long-term ovariectomy in female rats...
January 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28054156/parental-refusal-of-vitamin-k-and-neonatal-preventive-services-a-need-for-surveillance
#11
Lauren H Marcewicz, Joshua Clayton, Matthew Maenner, Erika Odom, Ekwutosi Okoroh, Deborah Christensen, Alyson Goodman, Michael D Warren, Julie Traylor, Angela Miller, Timothy Jones, John Dunn, William Schaffner, Althea Grant
Objectives Vitamin K deficiency bleeding (VKDB) in infants is a coagulopathy preventable with a single dose of injectable vitamin K at birth. The Tennessee Department of Health (TDH) and Centers for Disease Control and Prevention (CDC) investigated vitamin K refusal among parents in 2013 after learning of four cases of VKDB associated with prophylaxis refusal. Methods Chart reviews were conducted at Nashville-area hospitals for 2011-2013 and Tennessee birthing centers for 2013 to identify parents who had refused injectable vitamin K for their infants...
January 4, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28049025/correction-of-vitamin-d-deficiency-using-sublingually-administered-vitamin-d2-in-a-crohn-s-disease-patient-with-mal-absorption-and-a-new-ileostomy
#12
REVIEW
Patrick McCullough, Robert Heaney
Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2...
December 31, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28042676/vitamin-d-insufficiency-in-the-first-6-months-of-infancy-and-challenge-proven-ige-mediated-food-allergy-at-1-year-of-age-a-case-cohort-study
#13
John Molloy, Jennifer J Koplin, Katrina J Allen, Mimi L K Tang, Fiona Collier, John B Carlin, Richard Saffery, David Burgner, Sarath Ranganathan, Terence Dwyer, Alister C Ward, Margarita Moreno-Betancur, Michael Clarke, Anne Louise Ponsonby, Peter Vuillermin
BACKGROUND: Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for IgE-mediated food allergy. However there are no studies relating directly measured VDI during early infancy to subsequent challenge-proven food allergy. OBJECTIVE: To prospectively investigate the association between VDI during infancy and challenge-proven food allergy at 1 year. METHODS: In a birth cohort (n=1074), we used a case-cohort design to compare 25-hydroxy-vitamin-D3 (25(OH)D3 ) levels among infants with food allergy versus a random subcohort (n=274)...
January 2, 2017: Allergy
https://www.readbyqxmd.com/read/28040349/-effect-of-drugs-for-osteoporosis-on-cardiovascular-diseases-and-effect-of-cardio-vascular-drugs-on-osteoporosis
#14
Michel Laroche, Yannick Degboe, Hubert Blain, Véronique Breuil, Roland Chapurlat, Bernard Cortet, Bruno Sutter
Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomena of atherosclerotic plaque involve cytokines and growth factors also involved in bone remodeling. Drugs given for either of these two conditions could act on these mechanisms. Can osteoporosis drugs have an influence on the occurrence of cardiovascular events? Conversely, can the treatment of hypertension alter the course of osteoporosis? It is possible that administration of high doses of calcium (1g/day) in patients who already have important dietary intake can increase the risk of myocardial infarction...
December 28, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/28033496/association-of-uv-radiation-with-parkinson-disease-incidence-a-nationwide-french-ecologic-study
#15
Adam Kravietz, Sofiane Kab, Lucien Wald, Aline Dugravot, Archana Singh-Manoux, Frédéric Moisan, Alexis Elbaz
BACKGROUND: Vitamin D is thought to contribute to brain health, but it is unclear whether low vitamin D levels are associated with increased incidence of Parkinson's disease (PD). Using ultraviolet B (UV-B) as a surrogate for vitamin D levels, we conducted a nationwide ecologic study in France in order to examine the association of UV-B with PD incidence. METHODS: We used French national drug claims databases to identify PD cases using a validated algorithm. UV-B data from the solar radiation database were derived from satellite images...
December 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/28033244/effect-of-vitamin-d3-on-self-perceived-fatigue-a-double-blind-randomized-placebo-controlled-trial
#16
Albina Nowak, Lukas Boesch, Erik Andres, Edouard Battegay, Thorsten Hornemann, Christoph Schmid, Heike A Bischoff-Ferrari, Paolo M Suter, Pierre-Alexandre Krayenbuehl
BACKGROUND: Vitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials. METHODS: This is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 μg/L)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032704/treatment-and-management-of-osteoporotic-fractures-a-nation-wide-survey-of-484-senior-orthopaedists-in-china
#17
Yi Man, Wei Pan, Jin Lu, Sen-Yuan Li, Pian Zhang, Jun-Zhe Guo, Shu-Fang Yu, Bei Zhang, En Xiao, Chao Zhang, Wei Zuo, He-Juan Jin, Yi Chen, Bin Wu, Xiao-En Shi, Di Hong, Xun Liu, Ying-Xu Gao, Jing Li, Lu Yin, Qing-Yun Xue
OBJECTIVE: To investigate the treatment given to osteoporotic fracture patients by orthopaedists at major hospitals in China. METHODS: A 25-item quantitative questionnaire survey, categorized into five domains, including primary purpose of osteoporosis treatment, anti-osteoporosis therapy, calcium and vitamin D supplement, monitoring of osteoporosis, and knowledge of osteoporosis treatment, was designed to elicit information on orthopaedists' views on the treatment of osteoporotic fracture...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28032296/vitamin-d-musculoskeletal-health
#18
REVIEW
Harjit Pal Bhattoa, Jerzy Konstantynowicz, Natalia Laszcz, Marek Wojcik, Pawel Pludowski
Perhaps the role of Vitamin D supplementation has been most exhaustively studied in calcium absorption, skeletal wellbeing, muscular potency, balance and risk of falling. Nonetheless, new data has emerged and the recent research on sarcopenia makes the topic increasingly interesting. Given the socioeconomic burden of the musculoskeletal consequences of hypovitaminosis D it is vital to keep abreast with the latest literature in the field. The recommended Vitamin D supplementation dose should suffice to increase the serum 25 hydroxyvitamin D level to 30 ng/mL (75 nmol/L) and this level should be optimally maintained with a maintenance dose, particularly for those diagnosed with osteoporosis...
December 29, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28025694/low-vitamin-d-deficiency-in-irish-toddlers-despite-northerly-latitude-and-a-high-prevalence-of-inadequate-intakes
#19
Carol Ní Chaoimh, Elaine K McCarthy, Jonathan O'B Hourihane, Louise C Kenny, Alan D Irvine, Deirdre M Murray, Mairead E Kiely
PURPOSE: While reports of inadequate vitamin D intakes among young children are widespread, data on the prevalence of vitamin D deficiency are inconsistent. We aimed to quantify vitamin D intake and serum 25-hydroxyvitamin D [25(OH)D] concentrations in children aged 2 years in the prospective Cork BASELINE Birth Cohort Study. METHODS: Serum 25(OH)D was analysed using UPLC-MS/MS in 741 children living in Cork, Ireland (51°N). Two-day weighed food diaries were collected in 467 children, and 294 provided both a blood sample and a food diary...
December 26, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28025639/evaluation-of-bone-metabolism-in-critically-ill-patients-using-ctx-and-pinp
#20
Alexandra Gavala, Konstantinos Makris, Anna Korompeli, Pavlos Myrianthefs
Background. Prolonged immobilization, nutritional and vitamin D deficiency, and specific drug administration may lead to significant bone resorption. Methods and Patients. We prospectively evaluated critically ill patients admitted to the ICU for at least 10 days. Demographics, APACHE II, SOFA scores, length of stay (LOS), and drug administration were recorded. Blood collections were performed at baseline and on a weekly basis for five consecutive weeks. Serum levels of PINP, β-CTx, iPTH, and 25(OH)vitamin D were measured at each time-point...
2016: BioMed Research International
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