keyword
MENU ▼
Read by QxMD icon Read
search

vitamin d dose

keyword
https://www.readbyqxmd.com/read/29775091/chronotherapy-of-maxacalcitol-on-skin-inflammation-induced-by-topical-12-o-tetradecanoylphorbol-13-acetate-in-mice
#1
Daisuke Yoshioka, Hitoshi Ando, Kentaro Ushijima, Masafumi Kumazaki, Akio Fujimura
In general, chronotherapy is desirable for a more effective and/or safe dosage regimen. In this study, a daily rhythm of skin vitamin D receptor (VDR) and chronotherapeutic profiles of maxacalcitol, a vitamin D analogue, were evaluated using mice with skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This study showed that skin nuclear VDR expression in TPA-treated mice has a daily rhythm with the peak at the middle of active period. The effects of maxacalcitol were greater after dosing during early to middle of active period than those after dosing during early to middle of inactive period...
May 18, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29770700/quality-use-of-the-pathology-data-in-home-medicines-reviews-a-retrospective-evaluation
#2
Vera H Buss, Alison Shield, Sam Kosari, Mark Naunton
BACKGROUND: Laboratory tests can be important tools for the assessment of pharmacotherapy. Nonetheless, there are no previous studies that have explicitly focused on the role of pathology data in Home Medicines Reviews (HMR), an Australian medication review program. OBJECTIVE: Evaluate pharmacists' recommendations regarding laboratory testing in the medication review process. METHODS: This retrospective review of HMRs assessed the prevalence of the pathology data provided by general practitioners...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29768449/children-with-type-1-diabetes-who-experienced-a-honeymoon-phase-had-significantly-lower-ldl-cholesterol-5-years-after-diagnosis
#3
Benjamin Udoka Nwosu, Bo Zhang, Sanaa S Ayyoub, Stephanie Choi, Tony R Villalobos-Ortiz, Laura C Alonso, Bruce A Barton
IMPORTANCE: Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. AIM: To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status...
2018: PloS One
https://www.readbyqxmd.com/read/29768347/a-retrospective-study-of-alendronate-for-the-treatment-of-ankylosing-spondylitis
#4
Gang Li, Chang-An Lv, Li Tian, Lian-Jin Jin, Wei Zhao
This retrospective study assessed the effect of alendronate for treating patients with ankylosing spondylitis (AS).Eighty-six patients with AS were included in this retrospective study, and were divided into 2 groups. Forty-six patients in the intervention group received alendronate plus vitamin D (400 mg/day) and calcium (500 mg/day), while 40 patients in the control group received vitamin D and calcium only, the same dose as the intervention group. The primary outcome included bone densitometry. The secondary outcomes consisted of quality of life, measured by Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, disease activity, measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and functional status, measured by Bath Ankylosing Spondylitis Functional Index (BASFI), as well as the adverse events (AEs)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767694/shorter-time-to-pregnancy-with-increasing-preconception-carotene-concentrations-among-women-with-1-to-2-previous-pregnancy-losses
#5
Keewan Kim, Enrique F Schisterman, Robert M Silver, Brian D Wilcox, Anne M Lynch, Neil J Perkins, Richard W Browne, Laurie L Lesher, Joseph B Stanford, Aijun Ye, Jean Wactawski-Wende, Sunni L Mumford
Although maternal nutrition may impact fecundity, associations between preconception micronutrients and time to pregnancy (TTP) has not been examined. We assessed the relationship between preconception fat-soluble micronutrient concentrations and TTP among women with 1-2 prior pregnancy losses. This is a prospective cohort study of 1,228 women set in the EAGeR Trial (US, 2007-2011), which assessed the effect of preconception-initiated daily low dose aspirin on reproductive outcomes. We measured preconception zeaxanthin, cryptoxanthin, lycopene, α- and β-carotene, and α- and γ-tocopherol in serum...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29765146/do-dietary-calcium-and-vitamin-d-matter-in-men-with-prostate-cancer
#6
REVIEW
Thierry Capiod, Nicolas Barry Delongchamps, Natascha Pigat, Jean-Claude Souberbielle, Vincent Goffin
Active surveillance (AS) is an attractive alternative to immediate treatment for men with low-risk prostate cancer. Thus, the identification of environmental factors that promote the progression of indolent disease towards aggressive stages is critical to optimize clinical management. Epidemiological studies suggest that calcium-rich diets contribute to an increased risk of developing prostate cancer and that vitamin D reduces this risk. However, the potential effect of these nutrients on the progression of early-stage prostate tumours is uncertain, as studies in this setting are scarce and have not provided unambiguous conclusions...
May 15, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29764903/vitamin-d-supplementation-does-not-improve-cvd-risk-factors-in-vitamin-d-insufficient-subjects
#7
Julia Magdalena Kubiak, Per Medbøe Thorsby, Elena Kamycheva, Rolf Jorde
OBJECTIVE: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects. DESIGN: Double-blinded randomized controlled trial. METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, sRAGE, insulin, C-peptide, and HOMA-IR)...
May 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29762472/weaning-time-in-preterm-infants-an-audit-of-italian-primary-care-paediatricians
#8
Maria Elisabetta Baldassarre, Antonio Di Mauro, Annarita Pedico, Valentina Rizzo, Manuela Capozza, Fabio Meneghin, Gianluca Lista, Nicola Laforgia
INTRODUCTION: According to the 2016 Italian National Institute of Statistics (Istat) data in Italy, about 6.7% of all newborns are born prematurely. Due to the lack of data on current complementary feeding in preterm infants in Italy, the aim of the survey was to evaluate individual attitudes of primary care paediatricians, concerning the introduction of complementary foods in preterm infants. METHODS: An internet-based survey was conducted among primary care paediatricians, working in Italy, regarding (1) timing of the introduction of complementary foods to preterm newborns; (2) type of complementary foods introduced; (3) vitamin D and iron supplementations...
May 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29757043/effect-of-vitamin-d-supplementation-on-25-oh-d-status-in-elite-athletes-with-spinal-cord-injury
#9
Kelly Pritchett, Robert C Pritchett, Lauren Stark, Elizabeth Broad, Melissa LaCroix
Recent studies suggest that a substantial proportion of athletes with SCI (spinal cord injury) have insufficient 25(OH)D status which may be associated with decreased muscle strength. This study consisted of two parts: 1) to examine the effects of a 12 -16 week vitamin D3 supplementation protocol on 25(OH)D concentration and 2) to determine whether subsequent 25(OH)D status impacts muscle performance in elite athletes with SCI. Thirty-four members (age: 33 ± 15 years, weight: 69.6 ± 28.2kg, height: 170.2 ± 25...
May 14, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29755960/long-sun-exposures-influencing-high-sub-cutaneous-synthesis-of-vitamin-d3-may-be-associated-with-exacerbation-of-symptoms-in-allergic-asthma
#10
L G D'Cruz, S A Husain, T Wells, C Morgan, P J Stanczyk, A Satgunarajah, J Kashir, B L Calver, L M Blayney, F A Lai
Objectives: Does excessive sun-exposure, non-use of sunscreen and/or high doses of vitamin-D3 supplements provoke exacerbation of asthma? Design: Clinical examinations, retrospective records-access and questionnaire surveys were distributed to a convenience sample of allergic-asthma patient (n=183). Setting: Patients (19-89 years) attending the outpatient respiratory clinics at Maidstone Hospital were enrolled. Results: 90...
March 26, 2018: Journal of Aging Research & Clinical Practice
https://www.readbyqxmd.com/read/29755405/dual-paraneoplastic-endocrine-syndromes-heralding-onset-of-extrapulmonary-small-cell-carcinoma-a-case-report-and-narrative-review
#11
Jill B Feffer, Natalia M Branis, Jeanine B Albu
Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance. Methods: Clinical, laboratory, imaging, and pathology data are presented. Results: A 56-year-old man with locally advanced prostate adenocarcinoma on androgen deprivation therapy presented with a clogged nephrostomy tube...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29752008/a-genetic-variant-in-the-cytochrome-p450-family-2-subfamily-r-member-1-determines-response-to-vitamin-d-supplementation
#12
Afsane Bahrami, Mehrane Mehramiz, Majid Ghayour-Mobarhan, Hamidreza Bahrami-Taghanaki, Kiana Sadeghi Ardekani, Maryam Tayefi, Mahsa Sadeghzade, Mohammad Rashidmayvan, Maryam Safari Ghalezou, Gordon A Ferns, Amir Avan, Hamid Reza Sadeghnia
BACKGROUND: Globally, about 1 billion people have inadequate levels of serum vitamin D and it is prevalent in all ethnicities and age groups. Few foods naturally contain sufficient vitamin D; therefore, most people get their requirements through supplementation. Hence vitamin D status is affected by genetic and environmental determinants including season of measurement, diet habitual, health status, body mass index and concurrent medication. Further studies are necessary to understand how genetic variation influences vitamin D metabolism...
April 26, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29751504/emerging-evidence-of-thresholds-for-beneficial-effects-from-vitamin-d-supplementation
#13
REVIEW
Robert Scragg
Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29748907/effect-of-combined-vitamin-d-receptor-activator-and-lanthanum-carbonate-on-serum-fibroblast-growth-factor-23-level-in-predialysis-patients-cvd-laf-study-design-and-method
#14
Eri Ito, Daijo Inaguma, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa
BACKGROUND: Whether vitamin D receptor activator (VDRA) use is beneficial in chronic kidney disease (CKD) is unclear, because it is possible that VDRA increases serum fibroblast growth factor 23 (FGF23) levels. We will conduct a randomized controlled trial in predialysis patients to determine the effect of VDRA alone or in combination with lanthanum carbonate (LC) on serum FGF23 levels. METHODS: This is a single-center, open-label, randomized controlled trial. Enrollment will commence February 1, 2018, using the following inclusion criteria: (1) age ≥ 20 years, (2) CKD with an estimated glomerular filtration rate of 10-45 mL/min/1...
May 10, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29747301/-the-463rd-case-rhabdomyolysis-acute-kidney-failure-and-acute-hepatic-failure
#15
W Shi, D Wu, N Si, W Jiang, J Ma, X M Li
We represented a 22-year-old male patient who developed rhabdomyolysis, acute kidney failure and acute hepatic failure and was finally diagnosed as multiple acyl-CoA dehydrogenase deficiency. The patient appeared temporary stable status after high dose vitamine-B(2) supplement whereas deterioration was still fatal with pulmonary infection, acute respiratory failure and acute heart failure.
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29742726/igf-and-igfbp-as-an-index-for-discrimination-between-vitamin-d-supplementation-responders-and-nonresponders-in-overweight-saudi-subjects
#16
Nasser M Al-Daghri, Sobhy M Yakout, Kaiser Wani, Malak Nawaz Khan Khattak, Spiro D Garbis, George P Chrousos, Omar S Al-Attas, Majed S Alokail
Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level <50 nmol/L), aged 40...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742152/characterization-of-snf472-pharmacokinetics-and-efficacy-in-uremic-and-non-uremic-rats-models-of-cardiovascular-calcification
#17
Miguel D Ferrer, Markus Ketteler, Fernando Tur, Eva Tur, Bernat Isern, Carolina Salcedo, Pieter H Joubert, Geert J Behets, Ellen Neven, Patrick C D'Haese, Joan Perelló
End-stage renal disease is strongly associated with progressive cardiovascular calcification (CVC) and there is currently no therapy targeted to treat CVC. SNF472 is an experimental formulation under development for treatment of soft tissue calcification. We have investigated the pharmacokinetics of SNF472 administration in rats and its inhibitory effects on CVC. SNF472 was studied in three rat models: (1) prevention of vitamin D3-induced CVC with an intravenous SNF472 bolus of 1 mg/kg SNF472, (2) inhibition of progression of vitamin D3-induced CVC with a subcutaneous SNF472 bolus of 10 or 60 mg/kg SNF472, starting after calcification induction, (3) CVC in adenine-induced uremic rats treated with 50 mg/kg SNF472 via i...
2018: PloS One
https://www.readbyqxmd.com/read/29740870/asian-consensus-on-assessment-and-management-of-mild-to-moderate-plaque-psoriasis-with-topical-therapy
#18
Shinichi Imafuku, Min Zheng, Yayoi Tada, Xibao Zhang, Colin Theng, Suganthi Thevarajah, Yi Zhao, Hae Jun Song
A working group of dermatologists in Asian countries assessed the current status of psoriatic management in the region to prepare a consensus report on topical treatment in mild to moderate plaque psoriasis. Even though the association of psoriasis with systemic comorbidities is increasingly acknowledged, psoriasis is still lower in health-care priority lists in the region. The psychosocial impact of psoriasis may be greater in Asian countries due to cultural norms and social discrimination. Non-adherence to treatment is also common among Asians...
May 9, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29738396/hypovitaminosis-d-in-orthopaedic-trauma-which-guidelines-should-be-followed
#19
Brett Schiffman, Hobie Summers, Mitchell Bernstein, Frank DiSilvio, Sarah Foyil, William Lack
OBJECTIVE: To evaluate risk factors for hypovitaminosis D and determine the baseline vitamin D supplementation associated with normal vitamin D levels at presentation. DESIGN: Prospective observational study. SETTING: Level I trauma center. PATIENTS: 259 adult patients undergoing operative treatment for orthopaedic trauma (OTA 11-15, 21-23, 31-34, 41-44, 61-62, 70C, 81-82, 87) between January 1 and December 31, 2014...
May 3, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29737412/factors-associated-with-inadequate-responses-to-risedronate-in-japanese-patients-with-osteoporosis
#20
Ryo Okazaki, Ryoichi Muraoka, Masayuki Maehara, Daisuke Inoue
Factors associated with an inadequate response (IR) to bisphosphonates have been reported in many countries, but not in Japan, where the approved dose is half the global dose. We analyzed factors associated with IR to risedronate in Japanese patients with osteoporosis. This was a post hoc analysis of 1261 Japanese osteoporosis patients who received risedronate for 1 year in phase III trials. IR was defined as more than one new vertebral fracture (VF) and/or negative change in lumbar spine bone mineral density (BMD) at 1 year...
May 8, 2018: Journal of Bone and Mineral Metabolism
keyword
keyword
118422
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"