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https://www.readbyqxmd.com/read/29679523/the-incidence-of-tuberculosis-infection-in-hematopoietic-stem-cell-transplantation-recipients-a-retrospective-cohort-study-from-a-center-in-turkey
#1
Şahika Zeynep Akı, Gülsan Türköz Sucak, Özlem Güzel Tunçcan, Nurdan Köktürk, Esin Şenol
Our results question the role of TST due to low specificity and sensitivity in regions where BCG is mandatory and in patients with hematologic malignancies and suggest that these general guidelines do not seem to apply to all situations. This article is protected by copyright. All rights reserved.
April 21, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29663961/systematic-review-and-meta-analysis-of-adjunctive-corticosteroids-in-the-treatment-of-tuberculous-pericarditis
#2
I A George, B Thomas, J S Sadhu
SETTING: Tuberculosis (TB) is the most common cause of pericarditis worldwide and carries a high mortality, even with effective anti-tuberculosis treatment. In the light of a randomized control trial in 2014, the American Thoracic Society and the Centers for Disease Control and Prevention/Infectious Diseases Society of America recently revised their recommendations against the routine use of adjunctive corticosteroids. OBJECTIVE: To evaluate the strength of evidence that resulted in this reversal of the guideline recommendations on the use of adjunctive corticosteroids in TB pericarditis by a meta-analysis, followed by a sensitivity analysis...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29661197/relevance-and-acceptability-of-using-the-quantiferon-gold-test-qgit-to-screen-cd4-blood-draws-for-latent-tb-infection-among-plhiv-in-south-africa-formative-qualitative-research-findings-from-the-teko-trial
#3
Deanna Kerrigan, Carrie Tudor, Katlego Motlhaoleng, Limakatso Lebina, Cokiswa Qomfu, Ebrahim Variava, Sandy Chon, Neil Martinson, Jonathan E Golub
BACKGROUND: Tuberculosis (TB) is the leading cause of mortality among people living with HIV (PLHIV), despite the availability of effective preventive therapy. The TEKO trial is assessing the impact of using a blood test, Quantiferon-TB Gold In-Tube Test (QGIT), to screen for latent TB compared to the Tuberculin Screening Test (TST) among PLHIV in South Africa. METHODS: Fifty-six qualitative interviews were conducted with PLHIV and clinical providers participating in the TEKO trial...
April 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29660203/mycobacterium-tuberculosis-active-disease-and-latent-infection-in-a-renal-transplant-cohort
#4
Nastaran Rafiei, Jackie Williams, William R Mulley, James M Trauer, Grant A Jenkin, Benjamin A Rogers
BACKGROUND: Tuberculosis (TB) is a serious opportunistic infection in renal transplant recipients associated with high mortality. Screening and treatment of latent Mycobacterium tuberculosis infection (LTBI) offers an opportunity to prevent subsequent active disease. METHODS: We retrospectively reviewed the records of all adult patients who underwent renal transplantation at our centre from 2005 to 2014 to assess current screening practices, the risks for and burden of active TB...
April 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29642834/-risk-of-travel-associated-tuberculosis
#5
Süheyla Sürücüoğlu
Tuberculosis has spread by human movements throughout history. There have been reports indicating tuberculosis transmission on all travel vehicles, including aircrafts, ground vehicles and vessels until today. However, due to the ever increasing of air transportation and air travelling among countries with low and high tuberculosis incidence, transmission risk especially in aircrafts has become an important issue worldwide. But in many of the studies conducted in this regard, transmission of tuberculosis in aircrafts was found very low...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29629681/antibiotic-prescribing-practice-and-adherence-to-guidelines-in-primary-care-in-the-cape-town-metro-district-south-africa
#6
J Gasson, M Blockman, B Willems
BACKGROUND: Knowledge of antibiotic prescribing practice in primary care in South Africa is limited. As 80% of human antibiotic use is in primary care, this knowledge is important in view of the global problem of antibiotic resistance. OBJECTIVES: To assess antibiotic prescribing in primary care facilities in the Cape Town Metro District and compare it with current national guidelines, and to assess the reasons why prescriptions were not adherent to guidelines. METHODS: A retrospective medical record review was performed in April/May 2016...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29628698/drug-resistant-skeletal-tuberculosis-in-a-tertiary-care-centre-in-south-india
#7
J Arockiaraj, G S Balaji, V M Cherian, Jepegnanam T S, B P Thomas, Joy S Michael, P M Poonnoose
Back ground: Drug resistant tuberculosis is alarmingly on the rise especially in developing countries. Skeletal tuberculosis accounts up to 10% of all extra pulmonary tuberculosis. World Health Organisation (WHO) has not formulated guidelines for the management of Multi-drug resistant skeletal tuberculosis. Results: A retrospective analysis of patients treated for musculoskeletal tuberculosis was done, to study drug resistance patterns. The outcome was assessed both clinically and radiologically...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628202/health-status-of-afro-asian-refugees-in-an-italian-urban-area-a-cross-sectional-monocentric-study
#8
R Del Pinto, D Pietropaoli, U Russomando, P Evangelista, C Ferri
OBJECTIVES: The recent sociopolitical events in the Mediterranean and Middle Eastern areas have significantly impacted international migration flows. As disease prevalence and type are different among western and Afro-Asian countries, physicians dealing with refugees should be aware of their specific health needs. We aimed at evaluating the health status and disease history of refugees at their arrival in the urban area of L'Aquila (Italy). STUDY DESIGN: This is a monocentric cross-sectional study...
April 5, 2018: Public Health
https://www.readbyqxmd.com/read/29609965/bcg-vaccine-who-position-paper-february-2018-recommendations
#9
World Health Organization
This article presented the World Health Organization's (WHO) recommendations on the use of on Bacille Calmette-Guérin (BCG) vaccine excerpted from the BCG vaccines: WHO position paper - February 2018 published in the Weekly Epidemiological Record [1]. This position paper replaces the 2004 WHO position paper on Bacille Calmette-Guérin (BCG) vaccine [2] and the 2007 WHO revised BCG vaccination guidelines for infants at risk for human immunodeficiency virus (HIV) infection [3]. It incorporates recent developments in the tuberculosis (TB) field, provides revised guidance on the immunization of children infected with HIV, and re-emphasizes the importance of the birth dose...
March 30, 2018: Vaccine
https://www.readbyqxmd.com/read/29602847/protocol-for-the-mixed-methods-process-and-context-evaluation-of-the-tb-tobacco-randomised-controlled-trial-in-bangladesh-and-pakistan-a-hybrid-effectiveness-implementation-study
#10
Melanie Boeckmann, Iveta Nohavova, Omara Dogar, Eva Kralikova, Alexandra Pankova, Kamila Zvolska, Rumana Huque, Razia Fatima, Maryam Noor, Helen Elsey, Aziz Sheikh, Kamran Siddiqi, Daniel Kotz
INTRODUCTION: Tuberculosis (TB) remains a significant public health problem in South Asia. Tobacco use increases the risks of TB infection and TB progression. The TB& Tobacco placebo-controlled randomised trial aims to (1) assess the effectiveness of the tobacco cessation medication cytisine versus placebo when combined with behavioural support and (2) implement tobacco cessation medication and behavioural support as part of general TB care in Bangladesh and Pakistan. This paper summarises the process and context evaluation protocol embedded in the effectiveness-implementation hybrid design...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29599802/tuberculosis-induced-autoimmune-haemolytic-anaemia-a-systematic-review-to-find-out-common-clinical-presentations-investigation-findings-and-the-treatment-options
#11
REVIEW
Devarajan Rathish, Sisira Siribaddana
Background: Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods: PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29584796/should-sputum-negative-presumptive-tb-patients-be-actively-followed-to-identify-missing-cases-in-india
#12
S Waikar, A Pathak, V Ghule, A Kapoor, K Sagili, E R Babu, S Chadha
Setting: Sputum smear microscopy, the primary diagnostic tool used for diagnosis of tuberculosis (TB) in India's Revised National TB Control Programme (RNTCP), has low sensitivity, resulting in a significant number of TB cases reported as sputum-negative. As the revised guidelines pose challenges in implementation, sputum-negative presumptive TB (SNPT) patients are subjected to 2 weeks of antibiotics, followed by chest X-ray (CXR), resulting in significant loss to care among these cases. Objective: To determine whether reducing delays in CXR would yield additional TB cases and reduce initial loss to follow-up for diagnosis among SNPT cases...
December 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29581938/did-diabetes-mellitus-affect-treatment-outcome-in-drug-resistant-tuberculosis-patients-in-pakistan-from-2010-to-2014
#13
A Latif, A Ghafoor, A Wali, R Fatima, Mahboob Ul-Haq, A Yaqoob, Z Abdullah, H Najmi, N M Khan
Settings: All hospitals managing drug-resistant tuberculosis (DR-TB) according to national guidelines in Pakistan. Objectives: To assess the effect of diabetes mellitus (DM) and factors associated with unfavourable outcomes in DR-TB. Methods: A cross-sectional study based on a retrospective record review of patients enrolled on DR-TB treatment from 2010 to 2014 in Pakistan. DR-TB data reported to Pakistan's National TB Control Programme on a monthly basis were used for the study. Result: Among 5811 patients enrolled on second-line drugs, 8...
March 21, 2018: Public Health Action
https://www.readbyqxmd.com/read/29577042/physicians-perspectives-on-communication-and-decision-making-in-clinical-encounters-for-treatment-of-latent-tuberculosis-infection
#14
Claudia C Dobler, Sinthia Bosnic-Anticevich, Carol L Armour
The aim of the study was to explore the views of tuberculosis (TB) physicians on treatment of latent TB infection (LTBI), focusing on decision making and communication in clinical practice. 20 Australian TB physicians participated in a semistructured interview in person or over the telephone. Interviews were recorded, transcribed and analysed thematically. The study identified challenges that physicians face when discussing treatment for LTBI with patients. These included difficulties explaining the concept of latency (in particular to patients from culturally and linguistically diverse backgrounds) and providing guidance to patients while still framing treatment decisions as a choice...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29568202/differing-profiles-of-people-diagnosed-with-acute-and-chronic-hepatitis-b-virus-infection-in-british-columbia-canada
#15
Mawuena Binka, Zahid A Butt, Stanley Wong, Mei Chong, Jane A Buxton, Nuria Chapinal, Amanda Yu, Maria Alvarez, Maryam Darvishian, Jason Wong, Gina McGowan, Mikhail Torban, Mark Gilbert, Mark Tyndall, Mel Krajden, Naveed Z Janjua
AIM: To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus (HBV) infection in British Columbia (BC). METHODS: We used data from the BC Hepatitis Testers Cohort (BC-HTC), which includes all individuals tested for hepatitis C virus (HCV) or human immunodeficiency virus (HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990. These data were integrated with prescription drug, medical visit, hospitalization and mortality data...
March 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29563561/comorbidities-and-treatment-outcomes-in-multidrug-resistant-tuberculosis-a-systematic-review-and-meta-analysis
#16
Joel Philip Samuels, Aashna Sood, Jonathon R Campbell, Faiz Ahmad Khan, James Cameron Johnston
Little is known about the impact of comorbidities on multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to examine the effect of human immunodeficiency virus (HIV), diabetes, chronic kidney disease (CKD), alcohol misuse, and smoking on MDR/XDRTB treatment outcomes. We searched MEDLINE, EMBASE, Cochrane Central Registrar and Cochrane Database of Systematic Reviews as per PRISMA guidelines. Eligible studies were identified and treatment outcome data were extracted...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29562987/treatment-responses-in-multidrug-resistant-tuberculosis-in-germany
#17
J Heyckendorf, F van Leth, K Avsar, G Glattki, G Günther, B Kalsdorf, M Müller, I D Olaru, T Rolling, H J F Salzer, M Schuhmann, E Terhalle, C Lange
BACKGROUND: Excellent treatment outcomes have recently been reported for patients with multi/extensively drug-resistant tuberculosis (M/XDR-TB) in settings where optimal resources for individualised therapy are available. OBJECTIVE: To ascertain whether differences remain in treatment responses between patients with M/XDR-TB and those with non-M/XDR-TB. METHOD: Patients with TB were prospectively enrolled between March 2013 and March 2016 at five hospitals in Germany...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29562986/direct-costs-of-managing-adverse-drug-reactions-during-rifampicin-resistant-tuberculosis-treatment-in-south-africa
#18
K Schnippel, C Firnhaber, R Berhanu, L Page-Shipp, E Sinanovic
OBJECTIVE: To estimate the provider costs of managing adverse drug reactions (ADRs) to standard long-course treatment for multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) according to South African guidelines. METHODS: We parameterised a published Markov health state model for MDR/RR-TB with guidelines-based, bottom-up public-sector provider costing of ADR management. Frequency of ADR occurrence was extracted from the literature. Costs were estimated over 10 years, discounted 3% annually and tested using probabilistic sensitivity analysis...
April 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29560021/evaluating-a-framework-for-tuberculosis-screening-among-healthcare-workers-in-clinical-settings-inner-mongolia-china
#19
Shiming Cheng, Deanna Tollefson, Guangxue He, Yuan Li, Hui Guo, Shua Chai, Fangfang Gao, Fei Gao, Guoxin Han, Liping Ren, Yulin Ren, Jianbo Li, Lixia Wang, Jay K Varma, Dongmei Hu, Haiying Fan, Fei Zhao, Emily Bloss, Yu Wang, Carol Y Rao
Background: Health care workers are at high risk for tuberculosis (TB). China, a high burden TB country, has no policy on medical surveillance for TB among healthcare workers. In this paper, we evaluate whether China's national TB diagnostic guidelines could be used as a framework to screen healthcare workers for pulmonary TB disease in a clinical setting in China. Methods: Between April-August 2010, healthcare workers from 28 facilities in Inner Mongolia Autonomous Region, China were eligible for TB screening, comprised of symptom check, chest X-ray and tuberculin skin testing...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29547642/-before-xpert-i-only-had-my-expertise-a-qualitative-study-on-the-utilization-and-effects-of-xpert-technology-among-pediatricians-in-4-indian-cities
#20
Andrew McDowell, Neeraj Raizada, Sunil D Khaparde, Raghuram Rao, Sanjay Sarin, Aakshi Kalra, Virender Singh Salhotra, Sreenivas Achuthan Nair, Catharina Boehme, Claudia M Denkinger
BACKGROUND: Diagnosing tuberculosis (TB) in children presents considerable challenges. Upfront testing on Xpert® MTB/RIF ('Xpert')-a rapid molecular assay with high sensitivity and specificity-for pediatric presumptive TB patients, as recommended by India's Revised National Tuberculosis Control Program (RNTCP), can pave the way for early TB diagnosis. As part of an ongoing project implemented by Foundation for Innovative New Diagnostics (FIND) dedicated to providing upfront free-of-cost (FOC) Xpert testing to children seeking care in the public and private sectors, a qualitative assessment was designed to understand how national guidelines on TB diagnosis and Xpert technology have been integrated into the pediatric TB care practices of different health providers...
2018: PloS One
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