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Stroke young adults

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https://www.readbyqxmd.com/read/27927951/effects-of-the-selective-%C3%AE-5-gabaar-antagonist-s44819-on-excitability-in-the-human-brain-a-tms-emg-and-tms-eeg-phase-i-study
#1
Ghazaleh Darmani, Carl M Zipser, Gabriele M Böhmer, Karine Deschet, Florian Müller-Dahlhaus, Paolo Belardinelli, Matthias Schwab, Ulf Ziemann
: Alpha-5 gamma-aminobutyric acid type A receptors (α5-GABAARs) are located extrasynaptically, regulate neuronal excitability through tonic inhibition, and are fundamentally important for processes such as plasticity and learning. For example, pharmacological blockade of α5-GABAAR in mice with ischemic stroke improved recovery of function by normalizing exaggerated perilesional α5-GABAAR-dependent tonic inhibition. S44819 is a novel competitive selective antagonist of the α5-GABAAR at the GABA-binding site...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27924051/increased-stroke-burdens-among-the-low-income-young-and-middle-aged-in-rural-china
#2
Xianjia Ning, Jian Sun, Rongcai Jiang, Hongyan Lu, Lingling Bai, Min Shi, Jun Tu, Yanan Wu, Jinghua Wang, Jianning Zhang
BACKGROUND AND PURPOSE: Although stroke in the young and middle aged accounts for 31% of all strokes in China, the disease burden is unknown. We aimed to determine the secular trends in stroke incidence and the transition of subtypes in rural China over a 24-year period. METHODS: In 1992, 14 920 residents were recruited to participate in the Tianjin Brain Study. Stroke events and all deaths were registered annually. We assessed the trends in incidence of first-ever stroke, including intracerebral hemorrhage and ischemic stroke, among adults aged 35 to 64 years during 1992 to 1999, 2000 to 2007, and 2008 to 2015...
December 6, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27909201/infarct-pattern-and-collateral-status-in-adult-moyamoya-disease-a-multimodal-magnetic-resonance-imaging-study
#3
Dong Yeop Kim, Jeong Pyo Son, Je Young Yeon, Gyeong-Moon Kim, Jong-Soo Kim, Seung-Chyul Hong, Oh Young Bang
BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the progressive stenosis of large intracranial arteries and a hazy network of basal collaterals, called moyamoya vessels. Although hemodynamic studies have been applied in MMD patients, the mechanisms of stroke in MMD are still unclear. The present study evaluated the infarct pattern and collateral status using multimodal magnetic resonance imaging in MMD patients. METHODS: Adult MMD patients with acute ischemic stroke were prospectively recruited, and infarct pattern on diffusion-weighted imaging was evaluated...
December 1, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27906659/recurrent-cryptogenic-stroke-in-young-adult-linked-to-congenital-left-ventricular-diverticulum
#4
Nicolas Gaillard, Frederic Targosz, Jean Louis Bertrand, Denis Sablot, Zoubir Mourad Bensalah
No abstract text is available yet for this article.
November 15, 2016: Neurology
https://www.readbyqxmd.com/read/27890765/revascularization-of-moyamoya-angiopathy-in-older-adults
#5
Richard W Williamson, Adib A Abla, Joseph M Zabramski, Peter Nakaji, Robert F Spetzler, John E Wanebo
BACKGROUND: Moyamoya angiopathy most often presents in young people in the second and third decade of life. Although uncommon, it can present later in life. In this report, we present our results with moyamoya patients older than 50 years of age who were treated with surgical revascularization via either direct bypass or indirect bypass (encephaloduroarteriosynangiosis). METHODS: A retrospective review was conducted to identify patients with moyamoya disease who were treated with surgical revascularization at our institution between 2002 and 2015...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27881526/towards-the-genetic-basis-of-cerebral-venous-thrombosis-the-beast-consortium-a-study-protocol
#6
Ioana Cotlarciuc, Thomas Marjot, Muhammad S Khan, Sini Hiltunen, Elena Haapaniemi, Tiina M Metso, Jukka Putaala, Susanna M Zuurbier, Matthijs C Brouwer, Serena M Passamonti, Paolo Bucciarelli, Emanuela Pappalardo, Tasmin Patel, Paolo Costa, Marina Colombi, Patrícia Canhão, Aleksander Tkach, Rosa Santacroce, Maurizio Margaglione, Giovanni Favuzzi, Elvira Grandone, Donatella Colaizzo, Kostas Spengos, Antonio Arauz, Amanda Hodge, Reina Ditta, Stephanie Debette, Marialuisa Zedde, Guillaume Pare, José M Ferro, Vincent Thijs, Alessandro Pezzini, Jennifer J Majersik, Ida Martinelli, Jonathan M Coutinho, Turgut Tatlisumak, Pankaj Sharma
INTRODUCTION: Cerebral venous thrombosis (CVT) is a rare cerebrovascular condition accounting for <1% of all stroke cases and mainly affects young adults. Its genetic aetiology is not clearly elucidated. METHODS AND ANALYSIS: To better understand the genetic basis of CVT, we have established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) which aims to recruit highly phenotyped cases initially of European descent and later from other populations...
November 22, 2016: BMJ Open
https://www.readbyqxmd.com/read/27881427/ischemic-stroke-rate-increases-in-young-adults-evidence-for-a-generational-effect
#7
Joel N Swerdel, George G Rhoads, Jerry Q Cheng, Nora M Cosgrove, Abel E Moreyra, John B Kostis, William J Kostis
BACKGROUND: The incidence rates of ischemic stroke and ST-segment elevation myocardial infarction (STEMI) have decreased significantly in the United States since 1950. However, there is evidence of flattening of this trend or increasing rates for stroke in patients younger than 50 years. The objective of this study was to examine the changes in incidence rates of stroke and STEMI using an age-period-cohort model with statewide data from New Jersey. METHODS AND RESULTS: We obtained stroke and STEMI data for the years 1995-2014 from the Myocardial Infarction Data Acquisition System, a database of hospital discharges in New Jersey...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27879449/ethnic-comparison-of-clinical-characteristics-and-ischemic-stroke-subtypes-among-young-adult-patients-with-stroke-in-hawaii
#8
Kazuma Nakagawa, Cherisse S Ito, Sage L King
BACKGROUND AND PURPOSE: Native Hawaiians and other Pacific Islanders (NHOPI) with ischemic stroke have younger age of stroke onset compared with whites. However, ethnic differences in stroke subtypes in this population have been inadequately studied. METHODS: Consecutive young adult patients (aged ≤55 years) who were hospitalized for ischemic stroke between 2006 and 2012 at a tertiary center in Honolulu were studied. Clinical characteristics and stroke subtypes based on pathophysiological TOAST classification (Trial of Org 10172) of NHOPI and Asians were compared with whites...
November 22, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27878217/factors-associated-with-young-adults-knowledge-regarding-family-history-of-stroke
#9
Maria Jose Melo Ramos Lima, Thereza Maria Magalhães Moreira, Raquel Sampaio Florêncio, Predro Braga
Objective: to analyze the factors associated with young adults' knowledge regarding family history of stroke. Method: an analytical transversal study, with 579 young adults from state schools, with collection of sociodemographic, clinical and risk factor-related variables, analyzed using logistic regression (backward elimination). Results: a statistical association was detected between age, civil status, and classification of arterial blood pressure and abdominal circumference with knowledge of family history of stroke...
November 21, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27865756/association-of-insulin-dosage-with-mortality-or-major-adverse-cardiovascular-events-a-retrospective-cohort-study
#10
John-Michael Gamble, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Stephanie W Young, Don MacDonald, Sumit R Majumdar
BACKGROUND: Existing studies have shown conflicting evidence regarding the safety of exogenous insulin therapy in patients with type 2 diabetes. In particular, observational studies have reported an increased risk of death and cardiovascular disease among users of higher versus lower doses of insulin. We aimed to quantify the association between increasing dosage of insulin exposure and death and cardiovascular events, while taking into account time-dependent confounding and mediation that might have biased previous studies...
November 16, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27862055/reducing-stroke-risk-among-young-adult-african-americans-a-feasibility-study
#11
Dawn M Aycock, Patricia C Clark, Matthew J Hayat
African Americans are disproportionately affected by stroke and its modifiable risk factors, and strategies are needed to help African Americans adopt healthy lifestyles early in life. The purpose of this study was to assess the feasibility of the Stroke Counseling for Risk Reduction (SCORRE) intervention, a tailored, theory-based intervention consisting of a motivational video of young African American stroke survivors, the American Heart Association's Life's Simple 7® (LS7) risk assessment and education tool, and a 6-week behavioral risk reduction diary...
November 16, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27853491/dissection-of-extracranial-internal-carotid-artery-due-to-balloon-guiding-catheter-resulting-in-asymptomatic-internal-carotid-artery-occlusion
#12
Suha Akpinar, Guliz Yilmaz
Dissection of the internal carotid artery (ICA) is a rare condition that accounts for a significant proportion of ischemic strokes in young adults. Iatrogenic dissection as a complication of neurointerventional procedures is a traumatic dissection which has been reported relatively rare in the literature. In this report, a case of dissection of the ICA is reported that was caused by repetitive movement of the balloon guiding catheter during stent-assisted thrombectomy (SAT), resulting in occlusion of the ICA...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27843318/vertebral-artery-dissection-with-compelling-evidence-on-duplex-ultrasound-presenting-only-with-neck-pain
#13
Timo Siepmann, Monique Borchert, Kristian Barlinn
Vertebral artery dissection (VAD) is among the most common identifiable etiologies of stroke in young adults and poses a diagnostic challenge due to nonspecific symptoms and substantial variability of imaging results. Here, we present a case of unspecific neck pain as isolated symptom of VAD with unusually compelling evidence on duplex ultrasound. This observation has clinical relevance as the absence of any neurological symptoms in our patient highlights the necessity of considering cervical artery dissection in patients presenting with unspecific symptoms such as neck pain, even if isolated...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27834597/bypass-surgery-versus-medical-treatment-for-symptomatic-moyamoya-disease-in-adults
#14
Dong-Kyu Jang, Kwan-Sung Lee, Hyoung Kyun Rha, Pil-Woo Huh, Ji-Ho Yang, Ik Seong Park, Jae-Geun Ahn, Jae Hoon Sung, Young-Min Han
OBJECTIVE In this study the authors evaluated whether extracranial-intracranial bypass surgery can prevent stroke occurrence and decrease mortality in adult patients with symptomatic moyamoya disease (MMD). METHODS The medical records of 249 consecutive adult patients with symptomatic MMD that was confirmed by digital subtraction angiography between 2002 and 2011 at 8 institutions were retrospectively reviewed. The study outcomes of stroke recurrence as a primary event and death during the 6-year follow-up and perioperative complications within 30 days as secondary events were compared between the bypass and medical treatment groups...
November 11, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27825145/constitutional-chromoanagenesis-of-distal-13q-in-a-young-adult-with-recurrent-strokes
#15
Rachel D Burnside, April Harris, Darrow Speyer, W Scott Burgin, David Z Rose, Amarilis Sanchez-Valle
Constitutional chromoanagenesis events, which include chromoanasynthesis and chromothripsis and result in highly complex rearrangements, have been reported for only a few individuals. While rare, these phenomena have likely been underestimated in a constitutional setting as technologies that can accurately detect such complexity are relatively new to the mature field of clinical cytogenetics. G-banding is not likely to accurately identify chromoanasynthesis or chromothripsis, since the banding patterns of chromosomes are likely to be misidentified or oversimplified due to a much lower resolution...
November 9, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27816914/improving-stroke-caregiver-readiness-for-transition-from-inpatient-rehabilitation-to-home
#16
Barbara J Lutz, Mary Ellen Young, Kerry Rae Creasy, Crystal Martz, Lydia Eisenbrandt, Jarrett N Brunny, Christa Cook
PURPOSE: As the population ages, older adults are more often living with functional limitations from chronic illnesses, such as stroke, and require assistance. Because stroke occurs suddenly, many stroke family caregivers in the United States are unprepared to assume caregiving responsibilities post-discharge. Research is limited on how family members become ready to assume the caregiving role. In this study, we developed a theoretical model for improving stroke caregiver readiness and identifying gaps in caregiver preparation...
November 5, 2016: Gerontologist
https://www.readbyqxmd.com/read/27816347/cerebral-venous-thrombosis
#17
José Manuel Ferro, Patrícia Canhão, Diana Aguiar de Sousa
Cerebral venous thrombosis (CVT) has an incidence of 1.32/100,000/years in high-income countries, and higher in middle- and low-income countries. CVT is more frequent in infants and children young adults and females, especially during pregnancy/puerperium. CVT are now being diagnosed with increasing frequency because of the increased awareness and higher use of magnetic resonance imaging (MR) for investigating patients with acute and subacute headaches and new onset seizures. CVT rarely present as a stroke syndrome...
December 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27816343/epidemiology-of-stroke-in-europe-and-trends-for-the-21st-century
#18
Yannick Béjot, Henri Bailly, Jérôme Durier, Maurice Giroud
Despite major improvements in primary prevention and acute treatment over the last decades, stroke is still a devastating disease. At the beginning of the 21st century, the age-standardized incidence of stroke in Europe ranged from 95 to 290/100,000 per year, with one-month case-fatality rates ranging from 13 to 35%. Approximately 1.1 million inhabitants of Europe suffered a stroke each year, and ischemic stroke accounted for approximately 80% of cases. Although global stroke incidence is declining, rates observed in young adults are on the rise, thus suggesting a need for strategies to improve prevention...
December 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27810722/female-sex-young-age-northern-german-residence-hypoglycemia-and-disabling-diabetes-complications-are-associated-with-depressed-mood-in-the-who-5-questionnaire-a-multicenter-dpv-study-among-17-563-adult-patients-with-type-2-diabetes
#19
Nicole Prinz, Stefan Ebner, Arthur Grünerbel, Uwe Henkelüdecke, Norbert Hermanns, Michael Hummel, Claus Schäfer, Christian Wagner, Jörg Weiland, Reinhard Welp, Reinhard W Holl
BACKGROUND: Like other mental illnesses, depression is a culturally sensitive topic. Hence, findings cannot be transferred between countries. We investigated the frequency of depressed mood and its association with diabetes-related factors in a large type 2 diabetes (T2D) cohort from real-life care in Germany. METHODS: 17,563 adults (median [IQR]: 64.5[55.9-71.1] years) from the multicenter diabetes follow-up registry, DPV (diabetes prospective follow-up), were investigated...
October 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27805341/cocaine-abuse-an-unusual-association
#20
S C Chaudhary, K K Sawlani, H S Malhotra, Apurva, S Nanda, P K Rao
Cocaine addiction is a common problem in the adolescent and the young adults, pharmacologic interventions to reverse the effects of which do not exist. Neurological complications of cocaine abuse, such as seizures, headache, ischemic or hemorrhagic stroke, or subarachnoid hemorrhage, can be disastrous as a result of uncontrolled vasoconstriction and vasculitic damage. The lone occurrence of subdural hematoma in the absence of any other intracranial hemorrhagic complication is rarely seen in patients of cocaine abuse...
November 2016: Journal of the Association of Physicians of India
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