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Stroke young adults

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https://www.readbyqxmd.com/read/29351598/smooth-muscle-cells-of-intracranial-vessels-from-development-to-disease
#1
Juhana Frösen, Anne Joutel
Cerebrovascular diseases that cause ischemic or hemorrhagic stroke with subsequent loss of life or functional capacity due to damage of the brain tissue are among the leading causes of human suffering and economic burden inflicted by diseases in the developed world. Diseases affecting intracranial vessels are significant contributors to ischemic and hemorrhagic strokes. Brain arteriovenous malformations (bAVM), which are a collection of abnormal blood vessels connecting arteries to veins, are the most common cause of intracranial hemorrhage in children and young adults...
January 16, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29327525/drug-abuse-as-an-emanating-risk-for-stroke-in-young-adults
#2
Sulena, Anjani Kumar Sharma
Drug abuse is a substantial risk factor for stroke among patients under 45 years of age and ranks second among the most commonly identified potential risk factors. Drug abusers aged 15 to 44 years are 6.5 times more likely to have a stroke than non drug users. Stroke occurring in persons under 45 years of age accounts for only 4% of all strokes but causes an enormous toll in personal suffering, lost productivity, and health care costs.
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29321517/genome-wide-association-study-of-homocysteine-in-african-americans-from-the-jackson-heart-study-the-multi-ethnic-study-of-atherosclerosis-and-the-coronary-artery-risk-in-young-adults-study
#3
Laura M Raffield, Jaclyn Ellis, Nels C Olson, Qing Duan, Jin Li, Peter Durda, Nathan Pankratz, Brendan J Keating, Christina L Wassel, Mary Cushman, James G Wilson, Myron D Gross, Russell P Tracy, Stephen S Rich, Alex P Reiner, Yun Li, Monte S Willis, Ethan M Lange, Leslie A Lange
Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p < 5...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29307510/carotid-ultrasound-for-assessment-of-nonobstructive-carotid-atherosclerosis-in-young-adults-with-cryptogenic-stroke
#4
Raphael Buon, Brigitte Guidolin, Aude Jaffre, Marie Lafuma, Marianne Barbieux, Nathalie Nasr, Vincent Larrue
BACKGROUND: The role of nonobstructive (<50% stenosis) carotid atherosclerosis (NOCA) in young adults with ischemic stroke is not well understood. In the present study, we investigated the prevalence and the ultrasonic characteristics of NOCA in a consecutive series of young adults with cryptogenic stroke (CS). METHODS: Patients aged 18-54, consecutively treated in a tertiary hospital for first-ever CS (defined as an ischemic stroke without ASCOD (A: atherosclerosis; S: small-vessel disease; C: cardiac pathology; O: other causes) grade 1 potential cause) in the carotid artery territory, were prospectively enrolled...
January 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29298116/somatic-activating-kras-mutations-in-arteriovenous-malformations-of-the-brain
#5
Sergey I Nikolaev, Sandra Vetiska, Ximena Bonilla, Emilie Boudreau, Suvi Jauhiainen, Behnam Rezai Jahromi, Nadiya Khyzha, Peter V DiStefano, Santeri Suutarinen, Tim-Rasmus Kiehl, Vitor Mendes Pereira, Alexander M Herman, Timo Krings, Hugo Andrade-Barazarte, Takyee Tung, Taufik Valiante, Gelareh Zadeh, Mike Tymianski, Tuomas Rauramaa, Seppo Ylä-Herttuala, Joshua D Wythe, Stylianos E Antonarakis, Juhana Frösen, Jason E Fish, Ivan Radovanovic
BACKGROUND: Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown. METHODS: We analyzed tissue and blood samples from patients with arteriovenous malformations of the brain to detect somatic mutations. We performed exome DNA sequencing of tissue samples of arteriovenous malformations of the brain from 26 patients in the main study group and of paired blood samples from 17 of those patients...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29273593/novel-susceptibility-loci-for-moyamoya-disease-revealed-by-a-genome-wide-association-study
#6
Lian Duan, Ling Wei, Yanghua Tian, Zhengshan Zhang, Panpan Hu, Qiang Wei, Sugang Liu, Jun Zhang, Yuyang Wang, Desheng Li, Weizhong Yang, Rui Zong, Peng Xian, Cong Han, Xiangyang Bao, Feng Zhao, Jie Feng, Wei Liu, Wuchun Cao, Guoping Zhou, Chunyan Zhu, Fengqiong Yu, Weimin Yang, Yu Meng, Jingye Wang, Xianwen Chen, Yu Wang, Bing Shen, Bing Zhao, Jinghai Wan, Fengyu Zhang, Gang Zhao, Aimin Xu, Xuejun Zhang, Jianjun Liu, Xianbo Zuo, Kai Wang
BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare cerebral vasculopathy characterized by bilateral internal carotid artery stenosis and often leads to stroke in children or young adults. Although familial inheritance is well recognized, the genetic basis of MMD remains poorly understood. METHODS: A 2-stage genome-wide association study was conducted involving 1492 cases and 5084 controls. In the discovery stage, logistic regression was used to test associations, and imputation was conducted based on genotyped single-nucleotide polymorphisms (SNPs)...
January 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29246828/the-pathophysiology-of-the-vasovagal-response
#7
David L Jardine, Wouter Wieling, Michele Brignole, Jacques W M Lenders, Richard Sutton, Julian Stewart
In Part I we found that the classic studies of vasovagal syncope, done on fit young subjects, over stated vasodilatation as the dominant hypotensive mechanism. Since 1980, blood pressure and cardiac output have been measured continuously using non-invasive methods during tilt, mainly in patients with recurrent syncope, including women and the elderly. This has allowed us to analyse in more detail the complex sequence of hemodynamic changes leading up to syncope in the laboratory. All tilt-sensitive patients appear to progress through 4 phases: 1 early stabilisation, 2 circulatory instability, 3 terminal hypotension and 4 recovery...
December 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29245106/cerebral-arterio-venous-malformations-in-the-paediatric-population-angiographic-characteristics-multimodal-treatment-strategies-and-outcome
#8
Klaus-Peter Stein, Bernd-Otto Huetter, Sophia Goericke, Neriman Oezkan, Rebecca Leyrer, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure, Oliver Mueller
OBJECTIVES: Cerebral arterio-venous malformations (AVM) are considered congenital lesions, emerging as an important cause of haemorrhagic stroke in children. The potential influence of age on clinical presentation and angio-architecture have been analysed extensively in the last years. Yet, comparative studies comprising ascending age groups may be limited in their conclusions, especially when comparing young children and adults. It is the aim of this study to evaluate characteristic clinical and angiographic features of AVM within a paediatric subgroup and their correlation to age at presentation...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29241822/neural-correlates-of-gentle-skin-stroking-in-early-infancy
#9
Jetro J Tuulari, Noora M Scheinin, Satu Lehtola, Harri Merisaari, Jani Saunavaara, Riitta Parkkola, Isac Sehlstedt, Linnea Karlsson, Hasse Karlsson, Malin Björnsdotter
Physical expressions of affection play a foundational role in early brain development, but the neural correlates of affective touch processing in infancy remain unclear. We examined brain responses to gentle skin stroking, a type of tactile stimulus associated with affectionate touch, in young infants. Thirteen term-born infants aged 11-36days, recruited through the FinnBrain Birth Cohort Study, were included in the study. Soft brush strokes, which activate brain regions linked to somatosensory as well as socio-affective processing in children and adults, were applied to the skin of the right leg during functional magnetic resonance imaging...
October 24, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29218790/embolic-strokes-of-undetermined-source-in-young-adults-baseline-characteristics-and-long-term-outcome
#10
Nicolas Martinez-Majander, Karoliina Aarnio, Jani Pirinen, Tuomas Lumikari, Tuomo Nieminen, Mika Lehto, Juha Sinisalo, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
BACKGROUND: Embolic strokes of undetermined source (ESUS) is a recent entity, not yet thoroughly investigated in young stroke patients. We compared clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other etiological subgroups. METHODS: Among the 1008 patients aged 15 to 49 years with first-ever ischemic stroke in Helsinki Young Stroke Registry, we identified ESUS patients, and defined primary endpoints as recurrent stroke, composite vascular events, and all-cause mortality...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29209476/osteoarthritis-affects-health-related-quality-of-life-in-korean-adults-with-chronic-diseases-the-korea-national-health-and-nutritional-examination-surveys-2009-2013
#11
Ji Hye Yang, Kiheon Lee, Se Young Jung, Woo Kyung Bae, Hye Jin Ju, In Young Cho, Jae Kyeong Song, Hwa Yeon Park, Jong-Soo Han, Ga-Hye Lee, Ye Seul Bae
Background: Osteoarthritis (OA) is a chronic disease that commonly afflicts the elderly. This disease reduces the health-related quality of life (HRQoL) and causes a significant social burden. Whether the effect of coexisting chronic conditions on HRQoL varies according to the presence of OA remains unclear. Therefore, this study aimed to investigate this notion. Methods: A total of 13,395 participants were identified from the 2009-2013 Korean National Health and Nutrition Examination Survey for analysis...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29209475/the-relationship-between-the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-and-metabolic-syndrome
#12
Hyun-Gyu Shin, Young-Kwang Kim, Yong-Hwan Kim, Yo-Han Jung, Hee-Cheol Kang
Background: Metabolic syndrome is associated with cardiovascular diseases and is characterized by insulin resistance. Recent studies suggest that the triglyceride/high-density lipoprotein cholesterol (TG/HDLC) ratio predicts insulin resistance better than individual lipid levels, including TG, total cholesterol, low-density lipoprotein cholesterol (LDLC), or HDLC. We aimed to elucidate the relationship between the TG/HDLC ratio and metabolic syndrome in the general Korean population. Methods: We evaluated the data of adults ≥20 years old who were enrolled in the Korean National Health and Nutrition Examination Survey in 2013 and 2014...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29191528/web-vessels-literature-review-and-neurointerventional-management
#13
Benedito J A Pereira, Ulysses Caus Batista, Renato Tavares Tosello, Igor Neia Ströher, Alex Machado Baeta, Ronie Leo Piske
OBJECTIVE: The aim of this study was to describe 27 patients with 32 web vessels (WVs) from our practice and provide a review of the literature regarding imaging diagnostics, clinical presentation, and treatment of WVs. METHODS: A MEDLINE search was performed using combinations of the following terms: "stroke in young adults," "web," "recurrent stroke," "diaphragm-like," "atypical fibromuscular hyperplasia," "atypical fibromuscular dysplasia," "septal fibromuscular dysplasia," "septa," "diaphragms," "pseudovalvular folds," and "carotid diaphragm...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29189108/return-to-work-after-young-stroke-a-systematic-review
#14
Jodi D Edwards, Arunima Kapoor, Elizabeth Linkewich, Richard H Swartz
Background The incidence of stroke in young adults is increasing. While many young survivors are able to achieve a good physical recovery, subtle dysfunction in other domains, such as cognition, often persists, and could affect return to work. However, reported estimates of return to work and factors affecting vocational outcome post-stroke vary greatly. Aims The aims of this systematic review were to determine the frequency of return to work at different time points after stroke and identify predictors of return to work...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29187558/modeling-spatial-navigation-in-the-presence-of-dynamic-obstacles-a-differential-games-approach
#15
Anuja Darekar, Valery Goussev, Brad J McFadyen, Anouk Lamontagne, Joyce Fung
Obstacle circumvention strategies can be shaped by the dynamic interaction of an individual (evader) and an obstacle (pursuer). We have developed a mathematical model with predictive and emergent components, using experimental data from seven healthy young adults walking towards a target while avoiding collision with a stationary or moving obstacle (approaching head-on, or diagonally 30° left or right) in a virtual environment. Two linear properties from the predictive component enable the evader to predict the minimum distance between itself and the obstacle at all times, including the future intersection of trajectories...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29172921/immunity-and-inflammation-predictors-for-short-term-outcome-of-stroke-in-young-adults
#16
Xiaoqing Zhou, Fang Yu, Xianjing Feng, Junyan Wang, Zhibin Li, Qiong Zhan, Jian Xia
BACKGROUND: The current study was conducted to identify independent predictors of severity and short-term outcome of first-ever ischemic stroke in young adults. METHODS: We retrospectively enrolled 325 consecutive patients aged 18-49 years with first-ever ischemic stroke admitted to our center between April 2013 and June 2015. Variables were systematically registered and compared between patients with different neurological severity (mild stroke: National Institutes of Health Stroke Scale [NIHSS]≤8 and severe stroke:>8) and different stroke outcome (favorable: modified Rankin scale score 0-2 and unfavorable: 3-5 or death) at 14 days after stroke onset...
November 27, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29163742/endovascular-treatment-of-spontaneous-intracranial-internal-carotid-dissection-in-a-young-patient-affected-by-systemic-lupus-erythematosus-a-case-report
#17
Sergio Racchiusa, Marcello Longo, Gianmarco Bernava, Antonio Pitrone, Rosario Papa, Francesca Granata, Giuseppe Centorrino, Sergio Lucio Vinci
Systemic lupus erythematosus (SLE) increases the risk of cerebrovascular events due to vascular changes, resulting in the weakening of the vessel walls. Moreover, patients with SLE have more incidence of arterial lesions such as dissections. Internal carotid dissection (ICA) is an infrequent cause of ischemic stroke, representing 2% of all ischemic events. We present a case of ischemic stroke, caused by a spontaneous dissection of intracranial ICA, treated with endovascular stent implantation, in a 22-year-old woman affected by SLE, newly diagnosed...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29153576/coronary-artery-calcium-and-long-term%C3%A2-risk-of-death-myocardial%C3%A2-infarction-and-stroke-the-walter-reed-cohort-study
#18
Joshua D Mitchell, Robert Paisley, Patrick Moon, Eric Novak, Todd C Villines
OBJECTIVES: This study aimed to assess the long-term risk of death and atherosclerotic cardiovascular disease (ASCVD) outcomes, including stroke, in a real-world cohort that underwent coronary artery calcium (CAC) scoring. BACKGROUND: Large-scale, long-term studies assessing the independent relationship of CAC for prediction of ASCVD events, to include stroke, in young, low-risk patients are uncommon outside of the clinical trial setting. METHODS: A total of 23,637 consecutive subjects without ASCVD who underwent CAC scoring from 1997 to 2009 were studied...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29147634/intracranial-ischemic-infarct-due-to-blunt-force-trauma-in-a-high-school-football-player
#19
Brandon I Esianor, Ali S Haider, Margaret I Engelhardt, Tijani Osumah, Steven Vayalumkal, Richa Thakur, Dean Leonard, Jeffrey Haithcock, Kennith F Layton
Ischemic stroke is an uncommon cause of death among teenagers and young adults; however, the etiologies differ when compared to ischemic strokes in older individuals. Large-vessel atherosclerosis and small-vessel disease causing ischemic stroke are rare for the teenage population, while cervicocerebral arterial dissections account for up to 20% of ischemic strokes. Here, we present the case of a 16-year-old male who developed internal carotid artery dissection (ICAD) after a head injury and subsequently developed ischemic stroke and seizures...
September 7, 2017: Curēus
https://www.readbyqxmd.com/read/29132836/prevalence-of-fabry-disease-in-young-patients-with-stroke-in-argentina
#20
Ricardo C Reisin, Julieta Mazziotti, Luciana León Cejas, Alberto Zinnerman, Pablo Bonardo, Manuel Fernández Pardal, Alejandra Martínez, Patricia Riccio, Sebastián Ameriso, Eduardo Bendersky, Pedro Nofal, Patricia Cairola, Lorena Jure, Andrea Sotelo, Paula Rozenfeld, Romina Ceci, Ignacio Casas-Parera, Analía Sánchez Luceros
BACKGROUND: Fabry disease (FD) is an underdiagnosed cause of stroke in young adults, but the frequency of this association is largely unknown. We estimated the prevalence of FD in a nationwide cohort of young adults who had stroke and transient ischemic attack (TIA) in Argentina. METHODS: This was a prospective, multicenter study of stroke and FD in young adults (18-55 years) conducted in Argentina between 2011 and 2015. Patients were enrolled if they had had a TIA or an ischemic or hemorrhagic stroke within the previous 180 days...
November 10, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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