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Stroke young adults

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https://www.readbyqxmd.com/read/28329000/trajectory-formation-principles-are-the-same-after-mild-or-moderate-stroke
#1
Denis Mottet, Liesjet Elisabeth Henriette van Dokkum, Jérôme Froger, Abdelkader Gouaïch, Isabelle Laffont
When we make rapid reaching movements, we have to trade speed for accuracy. To do so, the trajectory of our hand is the result of an optimal balance between feed-forward and feed-back control in the face of signal-dependant noise in the sensorimotor system. How far do these principles of trajectory formation still apply after a stroke, for persons with mild to moderate sensorimotor deficits who recovered some reaching ability? Here, we examine the accuracy of fast hand reaching movements with a focus on the information capacity of the sensorimotor system and its relation to trajectory formation in young adults, in persons who had a stroke and in age-matched control participants...
2017: PloS One
https://www.readbyqxmd.com/read/28328828/the-advantage-of-ultrasonography-in-the-diagnosis-of-extracranial-vertebral-artery-dissection-two-case-reports
#2
Lijuan Yang, Haitao Ran
RATIONALE: With the rapid development in technology of vascular imaging, the detection of artery dissection is also gradually increasing. Cervical artery dissection, including carotid artery and vertebral artery dissection, is associated in at least 20% of young adult patients with stroke. So, the diagnosis of cervical artery has become a great challenge. PATIENT CONCERNS: We reported 2 patients who complained of dizziness and pain, the findings of US confirmed the presence of extracranial vertebral artery dissection...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28321414/medical-and-interventional-therapy-for-spontaneous-vertebral-artery-dissection-in-the-craniocervical-segment
#3
Guiyun Zhang, Zuoquan Chen
Background and Purpose. Spontaneous vertebral artery dissection (SVAD) is an important reason for posterior-circulation-ischemic stroke in the young and middle-aged population. Although some previous reports reveal a favorable outcome with conservative therapy, it is still controversial in the treatment of SVAD in some specific patients. Herein, we present our 10 years of clinical experience for SVAD at this location. Material and Methods. 20 patients with 20 SVADs in V2 and V3 segments were retrospectively studied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28300652/increased-risk-of-stroke-in-patients-with-osteoarthritis-a-population-based-cohort-study
#4
Pi-Shan Hsu, Hsuan-Hung Lin, Chi-Rong Li, Wei-Sheng Chung
OBJECTIVES: Osteoarthritis (OA) is related to carotid atherosclerosis. Few studies have investigated the incidence of cerebrovascular diseases in patients with OA. Therefore, we conducted a population-based cohort study to determine the incidence and risk of stroke in patients with OA. METHODS: We used data from Taiwan's Longitudinal Health Insurance Database 2000 to investigate the incidence of stroke in 43 635 patients with OA newly diagnosed between 2002 and 2003...
March 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28299202/the-role-for-infarct-volume-as-a-surrogate-measure-of-functional-outcome-following-ischemic-stroke
#5
Ryan C Turner, Kenneth DiPasquale, Aric F Logsdon, Zhenjun Tan, Zachary J Naser, Jason D Huber, Charles L Rosen, Brandon P Lucke-Wold
The failed translation of proposed therapeutic agents for ischemic stroke from preclinical to clinical studies has led to increased scrutiny of preclinical studies, namely the model and outcome measures utilized. Preclinical studies routinely use infarct volume as an experimental endpoint or measure in studies employing young-adult, healthy male animals despite the fact that clinically, ischemic stroke is a disease of the elderly and improvements in functional outcome from pre- to post-intervention remains the most widely utilized assessment...
December 2016: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28295858/non-obstructive-carotid-atherosclerosis-and-patent-foramen-ovale-in-young-adults-with-cryptogenic-stroke
#6
A Jaffre, B Guidolin, J-B Ruidavets, N Nasr, V Larrue
BACKGROUND AND PURPOSE: Up to 50% of ischaemic strokes in young adults are classified as cryptogenic despite extensive work-up. We sought to evaluate the prevalence of non-obstructive carotid atherosclerosis (NOCA) and its association with patent foramen ovale (PFO) in young adults with cryptogenic stroke (CS). METHODS: Patients aged 18-54 years, consecutively treated for first-ever CS in an academic stroke service, were included. NOCA was assessed using carotid ultrasound examination and was defined as carotid plaque with <50% stenosis...
March 15, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28267664/carotid-free-floating-thrombus-causing-stroke-in-a-young-woman-with-lupus-anticoagulant-a-case-report-and-review-of-the-literature
#7
Abolfazl Afsharfard, Barmak Gholizadeh, Younes Abdolalian, Seyed Masoud Hosseini
INTRODUCTION: In young adults Stroke is a challenging condition and various tests are needed to diagnose and manage its underlying problems. Free floating thrombosis of internal carotid artery (FFT-ICA) is one of the rare problems among carotid artery diseases which can lead to stroke in adults. Owing to limited cases of FFT-ICA there is not a worldwide accepted consensus on management of FFT-ICA, but some recurrences after medical management have been reported in the literature. PRESENTATION OF CASE: A-25-year old woman was referred to hospital with sudden onset aphasia and right sided hemiparesis...
February 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28264095/association-between-migraine-and-cervical-artery-dissection-the-italian-project-on-stroke-in-young-adults
#8
Valeria De Giuli, Mario Grassi, Corrado Lodigiani, Rosalba Patella, Marialuisa Zedde, Carlo Gandolfo, Andrea Zini, Maria Luisa DeLodovici, Maurizio Paciaroni, Massimo Del Sette, Cristiano Azzini, Antonella Toriello, Rossella Musolino, Rocco Salvatore Calabrò, Paolo Bovi, Maria Sessa, Alessandro Adami, Giorgio Silvestrelli, Anna Cavallini, Simona Marcheselli, Domenico Marco Bonifati, Nicoletta Checcarelli, Lucia Tancredi, Alberto Chiti, Enrico Maria Lotti, Elisabetta Del Zotto, Giampaolo Tomelleri, Alessandra Spalloni, Elisa Giorli, Paolo Costa, Loris Poli, Andrea Morotti, Filomena Caria, Alessia Lanari, Giacomo Giacalone, Paola Ferrazzi, Alessia Giossi, Valeria Piras, Davide Massucco, Cataldo D'Amore, Filomena Di Lisi, Ilaria Casetta, Laura Cucurachi, Masina Cotroneo, Alessandro De Vito, Elisa Coloberti, Maurizia Rasura, Anna Maria Simone, Massimo Gamba, Paolo Cerrato, Giuseppe Micieli, Giovanni Malferrari, Maurizio Melis, Licia Iacoviello, Alessandro Padovani, Alessandro Pezzini
Importance: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). Objective: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD...
March 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28258125/a-drosophila-model-of-dominant-inclusion-body-myopathy-3-shows-diminished-myosin-kinetics-that-reduce-muscle-power-and-yield-myofibrillar-defects
#9
Jennifer A Suggs, Girish C Melkani, Bernadette M Glasheen, Mia M Detor, Anju Melkani, Nathan P Marsan, Douglas M Swank, Sanford I Bernstein
Inclusion body myopathy type 3 (IBM-3) patients display congenital joint contractures with early-onset muscle weakness that becomes more severe in adults. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We previously expressed the corresponding myosin mutation (E701K) in homozygous Drosophila indirect flight muscles and recapitulated the myofibrillar degeneration and inclusion bodies observed in the human disease. We also found that purified E701K myosin has dramatically reduced actin-sliding velocity and ATPase levels...
March 3, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28257876/are-semantic-and-phonological-fluency-based-on-the-same-or-distinct-sets-of-cognitive-processes-insights-from-factor-analyses-in-healthy-adults-and-stroke-patients
#10
Charlotte S M Schmidt, Lena V Schumacher, Pia Römer, Rainer Leonhart, Lena Beume, Markus Martin, Andrea Dressing, Cornelius Weiller, Christoph P Kaller
Verbal fluency for semantic categories and phonological letters is frequently applied to studies of language and executive functions. Despite its popularity, it is still debated whether measures of semantic and phonological fluency reflect the same or distinct sets of cognitive processes. Word generation in the two task variants is believed to involve different types of search processes. Findings from the lesion and neuroimaging literature further suggest a stronger reliance of phonological and semantic fluency on frontal and temporal brain areas, respectively...
February 28, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28248917/ischemic-stroke-in-young-adults-profile-of-sarah-hospital-bras%C3%A3-lia-from-2008-to-2012
#11
Vinícius V A Montanaro, Denise D S Freitas, Miguel C M Ruiz, Eduardo B U Cavalcanti, Patricia B C Marinho, Maria C D N B Freitas, Eleonora M J D Oliveira
INTRODUCTION: The societal and economic impact of ischemic stroke in young adults is considerable. The etiological investigation of ischemic stroke in this population is also challenging. OBJECTIVE: To describe the characteristics of young patients with ischemic stroke admitted to a neurological rehabilitation program in Brazil. METHODS: This transversal retrospective study analyzed data from the electronic health records of 134 patients aged 18 to 45 years with ischemic stroke admitted from 2008 to 2012...
March 2017: Neurologist
https://www.readbyqxmd.com/read/28237318/strokes-are-possible-complications-of-cannabinoids-use
#12
REVIEW
Valérie Wolff, Emilie Jouanjus
It is critically important to identify all factors that may play a role in the recent increase of the incidence of stroke among the young population. Considering the worldwide use of cannabinoids (cannabis and synthetic cannabinoids), the recent legalization of their consumption in some countries, and their supposed involvement in cardiovascular events, we evaluated their role in the occurrence of neurovascular complications among the young. Ninety-eight patients were described in the literature as having a cannabinoids-related stroke (85 after cannabis use and 13 after synthetic cannabinoids)...
February 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28208075/socioeconomic-and-air-pollution-correlates-of-adult-asthma-heart-attack-and-stroke-risks-in-the-united-states-2010-2013
#13
Louis Anthony Tony Cox
Asthma in the United States has become an important public health issue, with many physicians, regulators, and scientists elsewhere expressing concern that criterion air pollutants have contributed to a rising tide of asthma cases and symptoms. This paper studies recent associations (from 2008 to 2012) between self-reported asthma experiences and potential predictors, including age, sex, income, education, smoking, and county-level average annual ambient concentrations of ozone (O3) and fine particulate matter (PM2...
February 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28207342/cumulative-lifetime-marijuana-use-and-incident-cardiovascular-disease-in-middle-age-the-coronary-artery-risk-development-in-young-adults-cardia-study
#14
Jared P Reis, Reto Auer, Michael P Bancks, David C Goff, Cora E Lewis, Mark J Pletcher, Jamal S Rana, James M Shikany, Stephen Sidney
OBJECTIVES: To investigate the effects of marijuana in the development of incident cardiovascular and cerebrovascular outcomes. METHODS: Participants were 5113 adults aged 18 to 30 years at baseline (1985-1986) from the Coronary Artery Risk Development in Young Adults study, who were followed for more than 25 years. We estimated cumulative lifetime exposure to marijuana using repeated assessments collected at examinations every 2 to 5 years. The primary outcome was incident cardiovascular disease (CVD) through 2013...
April 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28207191/cysteine-proteases-in-atherosclerosis
#15
REVIEW
Tommy Weiss Sadan, Israel Gotsman, Galia Blum
Atherosclerosis predisposes patients to cardiovascular diseases, such as myocardial infarction and stroke. Instigation of vascular injury is triggered by retention of lipids and inflammatory cells in the vascular endothelium. Whereas these vascular lesions develop in young adults and are mostly considered harmless, over time persistent inflammatory and remodeling processes will ultimately damage the arterial wall and cause a thrombotic event due to exposure of tissue factors into the lumen. Evidence from human tissues and pre-clinical animal models have clearly established the role of cathepsin cysteine proteases in the development and progression of vascular lesions...
February 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28199497/racial-differences-in-associations-of-blood-pressure-components-in-young-adulthood-with-incident-cardiovascular-disease-by-middle-age-coronary-artery-risk-development-in-young-adults-cardia-study
#16
Yuichiro Yano, Jared P Reis, Yacob G Tedla, David C Goff, David R Jacobs, Stephen Sidney, Hongyan Ning, Kiang Liu, Philip Greenland, Donald M Lloyd-Jones
Importance: Data are sparse regarding which blood pressure (BP) components in young adulthood optimally determine cardiovascular disease (CVD) by middle age. Objectives: To assess which BP components best determine incident CVD events in young adults and determine whether these associations vary by race and age at BP measurement. Design, Setting, and Participants: Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, this study assessed the longitudinal race-stratified associations between BP and cardiovascular outcomes...
February 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28196265/association-of-coronary-artery-calcium-in-adults-aged-32-to-46-years-with-incident-coronary-heart-disease-and-death
#17
John Jeffrey Carr, David R Jacobs, James G Terry, Christina M Shay, Stephen Sidney, Kiang Liu, Pamela J Schreiner, Cora E Lewis, James M Shikany, Jared P Reis, David C Goff
Importance: Coronary artery calcium (CAC) is associated with coronary heart disease (CHD) and cardiovascular disease (CVD); however, prognostic data on CAC are limited in younger adults. Objective: To determine if CAC in adults aged 32 to 46 years is associated with incident clinical CHD, CVD, and all-cause mortality during 12.5 years of follow-up. Design, Setting, and Participants: The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a prospective community-based study that recruited 5115 black and white participants aged 18 to 30 years from March 25, 1985, to June 7, 1986...
February 8, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28196151/estimation-of-years-lived-with-disability-due-to-noncommunicable-diseases-and-injuries-using-a-population-representative-survey
#18
Ji In Park, Hae Hyuk Jung
The Global Burden of Disease 2010 and the WHO Global Health Estimates of years lived with disability (YLDs) uses disability-weights obtained from lay health-state descriptions, which cannot fully reflect different disease manifestations, according to severity, treatment, and environment. The aim of this study was to provide population-representative YLDs of noncommunicable diseases and injuries using a prevalence-based approach, with the disability weight measured in subjects with specific diseases or injuries...
2017: PloS One
https://www.readbyqxmd.com/read/28188400/-juvenile-stroke-what-is-important
#19
M Fischer, B Eckert, J Röther
Stroke in young adults is a diagnostic and therapeutic challenge for all persons involved. Approximately 15% of ischemic strokes occur in young adults. Lack of awareness of the symptoms in emergency departments often results in delayed diagnosis and access to specific therapeutic options, such as revascularization. The causes are often heterogeneous and necessitate specific investigations. The etiology of juvenile stroke includes drug abuse, vasculitis and arteriopathies, such as reversible vasoconstriction syndrome and posterior reversible encephalopathy syndrome, although the prevalence of classical vascular risk factors is high...
February 10, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28188327/tactile-stimuli-affect-long-range-correlations-of-stride-interval-and-stride-length-differently-during-walking
#20
Jung Hung Chien, V N Pradeep Ambati, Chun-Kai Huang, Mukul Mukherjee
Sensory feedback below the sole of the foot using sub-threshold mechanical noise significantly reduced postural sway in patients with diabetes and stroke. However, the effects of tactile parameters on walking are still elusive. Specifically, the effects of such parameters on human gait variability need to be studied because of possible rehabilitation outcomes in terms of bringing improvement in temporal and spatial gait parameters. The purpose of this study was to investigate whether different frequency and amplitude combinations of vibro-tactile stimulation of feet would affect stride-to-stride variability in healthy young adults...
April 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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