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Stroke young adults

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https://www.readbyqxmd.com/read/28626830/overweight-obesity-and-risk-of-cardiometabolic-multimorbidity-pooled-analysis-of-individual-level-data-for-120%C3%A2-813-adults-from-16-cohort-studies-from-the-usa-and-europe
#1
Mika Kivimäki, Eeva Kuosma, Jane E Ferrie, Ritva Luukkonen, Solja T Nyberg, Lars Alfredsson, G David Batty, Eric J Brunner, Eleonor Fransson, Marcel Goldberg, Anders Knutsson, Markku Koskenvuo, Maria Nordin, Tuula Oksanen, Jaana Pentti, Reiner Rugulies, Martin J Shipley, Archana Singh-Manoux, Andrew Steptoe, Sakari B Suominen, Töres Theorell, Jussi Vahtera, Marianna Virtanen, Peter Westerholm, Hugo Westerlund, Marie Zins, Mark Hamer, Joshua A Bell, Adam G Tabak, Markus Jokela
BACKGROUND: Although overweight and obesity have been studied in relation to individual cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is poorly understood. Here we aimed to establish the risk of incident cardiometabolic multimorbidity (ie, at least two from: type 2 diabetes, coronary heart disease, and stroke) in adults who are overweight and obese compared with those who are a healthy weight. METHODS: We pooled individual-participant data for BMI and incident cardiometabolic multimorbidity from 16 prospective cohort studies from the USA and Europe...
June 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28619986/contribution-of-established-stroke-risk-factors-to-the-burden-of-stroke-in-young-adults
#2
Annette Aigner, Ulrike Grittner, Arndt Rolfs, Bo Norrving, Bob Siegerink, Markus A Busch
BACKGROUND AND PURPOSE: As stroke in young adults is assumed to have different etiologies and risk factors than in older populations, the aim of this study was to examine the contribution of established potentially modifiable cardiovascular risk factors to the burden of stroke in young adults. METHODS: A German nationwide case-control study based on patients enrolled in the SIFAP1 study (Stroke In Young Fabry Patients) 2007 to 2010 and controls from the population-based GEDA study (German Health Update) 2009 to 2010 was performed...
June 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28619834/temporal-and-spatial-variances-in-arterial-spin-labeling-are-inversely-related-to-large-artery-blood-velocity
#3
A D Robertson, G Matta, V S Basile, S E Black, C K Macgowan, J A Detre, B J MacIntosh
BACKGROUND AND PURPOSE: The relationship between extracranial large-artery characteristics and arterial spin-labeling MR imaging may influence the quality of arterial spin-labeling-CBF images for older adults with and without vascular pathology. We hypothesized that extracranial arterial blood velocity can explain between-person differences in arterial spin-labeling data systematically across clinical populations. MATERIALS AND METHODS: We performed consecutive pseudocontinuous arterial spin-labeling and phase-contrast MR imaging on 82 individuals (20 - 88 years of age, 50% women), including healthy young adults, healthy older adults, and older adults with cerebral small vessel disease or chronic stroke infarcts...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28596958/circulating-cellular-adhesion-molecules-and-cognitive-function-the-coronary-artery-risk-development-in-young-adults-study
#4
Cynthia Yursun Yoon, Lyn M Steffen, Myron D Gross, Lenore J Launer, Andrew Odegaard, Alexander Reiner, Otto Sanchez, Kristine Yaffe, Stephen Sidney, David R Jacobs
OBJECTIVE: Higher circulating concentrations of cellular adhesion molecules (CAMs) can be used as markers of endothelial dysfunction. Given that the brain is highly vascularized, we assessed whether endothelial function is associated with cognitive performance. METHOD: Within the Coronary Artery Risk Development in Young Adults (CARDIA) Study, excluding N = 54 with stroke before year 25, we studied CAMs among N = 2,690 black and white men and women in CARDIA year 7 (1992-1993, ages 25-37) and N = 2,848 in CARDIA year 15 (2000-2001, ages 33-45)...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28596458/prevalence-of-fabry-disease-and-outcomes-in-young-canadian-patients-with-cryptogenic-ischemic-cerebrovascular-events
#5
Sylvain Lanthier, Gustavo Saposnik, Gerald Lebovic, Karen Pope, Daniel Selchen, David F Moore
BACKGROUND AND PURPOSE: Previous studies reported Fabry disease in 0% to 4% of young patients with cryptogenic ischemic stroke (IS). We sought to determine the prevalence of Fabry and outcomes among young Canadians with cryptogenic IS or transient ischemic attack (TIA). METHODS: We prospectively enrolled individuals aged 18 to 55 with IS or speech or motor TIA, and no cause identified despite predetermined investigation. α-galactosidase-A gene was sequenced for Fabry diagnosis...
June 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28554136/differences-between-the-chewing-and-non-chewing-sides-of-the-mandibular-first-molars-and-condyles-in-the-closing-phase-during-chewing-in-normal-subjects
#6
Hiroshi Tomonari, Sangho Kwon, Takaharu Kuninori, Shouichi Miyawaki
OBJECTIVE: This study aimed to assess differences between the closing paths of the chewing and non-chewing sides of mandibular first molars and condyles during natural mastication, using standardized model food in healthy subjects. DESIGN: Thirty-two healthy young adults (age: 19-25 years; 22 men, 10 women) with normal occlusion and function chewed on standardized gummy jelly. Using an optoelectric jaw-tracking system with six degrees of freedom, we recorded the path of the mandibular first molars and condyles on both sides for 10 strokes during unilateral chewing...
May 17, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28540180/hemoglobin-and-mean-platelet-volume-predicts-diffuse-t1-mri-white-matter-volume-decrease-in-sickle-cell-disease-patients
#7
Soyoung Choi, Adam M Bush, Matthew T Borzage, Anand A Joshi, William J Mack, Thomas D Coates, Richard M Leahy, John C Wood
Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic systemic and cerebral vascular disease that leads to early and cumulative neurological damage. Few studies have quantified the effects of this disease on brain morphometry and even fewer efforts have been devoted to older patients despite the progressive nature of the disease. This study quantifies global and regional brain volumes in adolescent and young adult patients with SCD and racially matched controls with the aim of distinguishing between age related changes associated with normal brain maturation and damage from sickle cell disease...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28534705/risk-factors-and-mechanisms-of-stroke-in-young-adults-the-future-study
#8
Mayte E van Alebeek, Renate M Arntz, Merel S Ekker, Nathalie E Synhaeve, Noortje Amm Maaijwee, Hennie Schoonderwaldt, Maureen J van der Vlugt, Ewoud J van Dijk, Loes Ca Rutten-Jacobs, Frank-Erik de Leeuw
Incidence of ischemic stroke and transient ischemic attack in young adults is rising. However, etiology remains unknown in 30-40% of these patients when current classification systems designed for the elderly are used. Our aim was to identify risk factors according to a pediatric approach, which might lead to both better identification of risk factors and provide a stepping stone for the understanding of disease mechanism, particularly in patients currently classified as "unknown etiology". Risk factors of 656 young stroke patients (aged 18-50) of the FUTURE study were categorized according to the "International Pediatric Stroke Study" (IPSS), with stratification on gender, age and stroke of "unknown etiology"...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28534242/lvot-vti-is-a-useful-indicator-of-low-ventricular-function-in-young-patients
#9
Manchula Navaratnam, Rajesh Punn, Chandra Ramamoorthy, Theresa A Tacy
Left ventricular outflow tract velocity time integral (LVOT-VTI), a Doppler-derived measure of stroke distance, is used as a surrogate marker of cardiac function in adults. LVOT-VTI is easily obtained, independent of ventricular geometry and wall motion abnormalities. We investigated the relationship between LVOT-VTI and conventional measures of function in young patients by comparing controls to children with dilated cardiomyopathy (DCM). Sixty-two healthy and 52 DCM patients over 1 year were studied retrospectively...
May 22, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28478690/assessment-of-texture-discrimination-ability-at-the-sole-of-the-foot-in-subjects-with-chronic-stroke-compared-with-young-and-elderly-subjects-with-no-neurological-deficits-a-reliability-and-validity-study
#10
Hadas Ofek, Mordechai Alperin, Tsipi Knoll, Daphna Livne, Yocheved Laufer
PURPOSE: To examine validity and test-retest reliability of a sensory test developed to evaluate ability of elderly subjects with/out a stroke to discriminate between textures with the sole of their foot. METHODS: Subjects poststroke, old adults and young subjects were tested twice. Twelve materials relevant to foot function (e.g., gravel, sand) were used. Blindfolded subjects were requested to discriminate with the sole of each foot one outstanding texture among three textures presented in each of 12 subtests...
May 8, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28474994/meta-analysis-of-the-surgical-outcomes-of-symptomatic-moyamoya-disease-in-adults
#11
Jin Pyeong Jeon, Jeong Eun Kim, Won-Sang Cho, Jae Seung Bang, Young-Je Son, Chang Wan Oh
OBJECTIVE The purpose of this study was to evaluate treatment outcomes of future stroke prevention, perioperative complications, and angiographic revascularization in adults with symptomatic moyamoya disease (MMD) according to treatment modalities and surgical techniques. METHODS A systemic literature review was performed based on searches of the PubMed, Embase, and Cochrane Central databases. A fixed-effects model was used in cases of heterogeneity less than 50%. Publication bias was determined by Begg's funnel plot, Egger's test of the intercept, and the Begg and Mazumdar rank correlation test...
May 5, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28468691/language-representation-following-left-mca-stroke-in-children-and-adults-an-fmri-study
#12
Robyn Westmacott, Mary Pat McAndrews, Gabrielle deVeber
BACKGROUND: In this case series, functional magnetic resonance imaging was used to examine brain networks that mediate different aspects of language function in 4 young adults (17-22 years) with a history of left middle cerebral artery (MCA) stroke in childhood (40 years of age). Although it is widely believed that altered lateralization patterns are more likely to occur following early brain injuries compared with later brain injuries, the presumed plasticity of the young brain has been challenged in recent years, particularly in the domain of language...
May 4, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28462222/the-ross-procedure-time-for-a-hard-look-at-current-practices-and-a-reexamination-of-the-guidelines
#13
EDITORIAL
Ismail El-Hamamsy, Ismail Bouhout
The ideal aortic valve substitute for young adults requiring aortic valve replacement (AVR) remains elusive. Young and middle-aged patients have a longer anticipated life expectancy and a higher level of physical activity than their elderly counterparts. In recent years, there has been a growing focus on long-term outcomes following AVR in this specific patient population. These studies highlight the direct impact of the choice of prosthesis on long-term survival, quality of life and rates of valve-related complications in younger adults...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28461834/vertebral-artery-dissection-a-contemporary-perspective
#14
Tiu Cristina, Terecoasa Elena, Grecu Nicolae, Nistor Raluca, Frangu Smaranda, Antochi Florina
Arterial dissections are among the most frequent causes of stroke in young adults. Usually they are associated with trauma, but as the modern imaging tools are evolving, more dissections are being diagnosed and more etiologies are being described. Vertebral artery dissections (VADs) have the distinct particularity that they can cause ischemic stroke (in the brainstem, cerebellum or even the spinal cord), but also subarachnoid hemorrhage, when the dissection occurs in the intracranial segment of the vertebral artery...
June 2016: Mædica
https://www.readbyqxmd.com/read/28459764/the-effect-of-the-bedtime-dosing-doxazosin-on-nocturnal-hypoxia-triggered-blood-pressure-surge-in-a-young-adult-man-with-severe-obstructive-sleep-apnea-syndrome-and-a-history-of-three-recurrent-sleep-onset-strokes
#15
Tetsuro Yoshida, Mitsuo Kuwabara, Satoshi Hoshide, Kazuomi Kario
No abstract text is available yet for this article.
June 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28448183/age-related-change-in-contribution-of-stroke-volume-to-central-pulse-pressure
#16
Atsushi Nakagomi, Sho Okada, Nobusada Funabashi, Yoshio Kobayashi
We investigated age-related change in the contribution of stroke volume (SV) to central PP (cPP). Eighty seven adult subjects who were free of vasoactive agents were included. Subjects were divided into three age groups: young (20-39 years, n = 26), middle (40-49 years, n = 29), and old (≥50 years, n = 32). SV was calculated by Doppler echocardiography. Hemodynamic indices were measured using a brachial cuff-based oscillometric method. The brachial and cPP showed a small decline from the young group to the middle group and a greater rise after 50 years old...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28447573/improving-neurorepair-in-stroke-brain-through-endogenous-neurogenesis-enhancing-drugs
#17
Kuo-Jen Wu, Seongjin Yu, Jea-Young Lee, Barry Hoffer, Yun Wang
Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy...
April 26, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28446515/role-of-biomarkers-for-the-prevention-assessment-and-management-of-heart-failure-a-scientific-statement-from-the-american-heart-association
#18
REVIEW
Sheryl L Chow, Alan S Maisel, Inder Anand, Biykem Bozkurt, Rudolf A de Boer, G Michael Felker, Gregg C Fonarow, Barry Greenberg, James L Januzzi, Michael S Kiernan, Peter P Liu, Thomas J Wang, Clyde W Yancy, Michael R Zile
BACKGROUND AND PURPOSE: Natriuretic peptides have led the way as a diagnostic and prognostic tool for the diagnosis and management of heart failure (HF). More recent evidence suggests that natriuretic peptides along with the next generation of biomarkers may provide added value to medical management, which could potentially lower risk of mortality and readmissions. The purpose of this scientific statement is to summarize the existing literature and to provide guidance for the utility of currently available biomarkers...
April 26, 2017: Circulation
https://www.readbyqxmd.com/read/28408257/ischemic-stroke-in-young-adults-with-moyamoya-disease-prognostic-factors-for-stroke-recurrence-and-functional-outcome-after-revascularization
#19
Meng Zhao, Xiaofeng Deng, Faliang Gao, Dong Zhang, Shuo Wang, Yan Zhang, Rong Wang, Jizong Zhao
OBJECTIVE: Stroke in young adults is uncommon and have rarely been described. Moyamoya disease is one of the leading causes of stroke in young adults. We aimed to study the prognostic factors for stroke recurrences and functional outcomes in young stroke patients with moyamoya disease after revascularization. METHODS: We reviewed 696 consecutive patients with moyamoya disease admitted to our hospital from 2009 to 2015 and identified patients aged 18-45 years with first-ever stroke...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28407021/analysis-of-the-prevalence-and-associated-factors-of-overactive-bladder-in-adult-korean-men
#20
So Young Kim, Woojin Bang, Hyo Geun Choi
Overactive bladder (OAB) is a prevalent condition characterized by lower urinary tract symptoms (LUTS). Age, education, income, marital status, sleep, and emotional problems have been associated with OAB; however, conflicting results exist. The present study was conducted to estimate the prevalence of OAB and comprehensively analyze its associated factors in a large cross-sectional, population-based study. The data of 94,554 participants aged 19-107 were analyzed from the Korean Community Health Survey (KCHS) of 2012...
2017: PloS One
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