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Cytokine mood disorder

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https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#1
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28025071/th17-cells-correlate-positively-to-the-structural-and-functional-integrity-of-the-brain-in-bipolar-depression-and-healthy-controls
#2
Sara Poletti, Harm de Wit, Elena Mazza, Annemarie J M Wijkhuijs, Clara Locatelli, Veronica Aggio, Cristina Colombo, Francesco Benedetti, Hemmo A Drexhage
: Abnormalities of T cell-mediated immune activation, in the absence of active somatic immune diseases, have consistently been reported in mood disorders. Apart from being important players in the regulation of cells of the immune system, T cells are essential for normal brain development. We here report studies on the relationship between circulating levels of T helper cells and structural and functional brain imaging in depressed bipolar patients. Since the CCL20-CCR6 axis is an important entry to the brain we differentiated the various T helper cell subpopulations on the basis of their chemokine receptor expression...
December 23, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27981186/integrating-interleukin-6-into-depression-diagnosis-and-treatment
#3
REVIEW
Georgia E Hodes, Caroline Ménard, Scott J Russo
There is growing evidence of a relationship between inflammation and psychiatric illness. In particular, the cytokine Interleukin-6 (IL-6) has been linked to stress-related disorders such as depression and anxiety. Here we discuss evidence from preclinical and clinical studies examining the role of IL-6 in mood disorders. We focus on the functional role of peripheral and central release of IL-6 on the development of stress susceptibility and depression-associated behavior. By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, we hope to broaden the way the field thinks about diagnosing and treating mood disorders...
October 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27913990/sirukumab-a-potential-treatment-for-mood-disorders
#4
REVIEW
Aileen J Zhou, Yena Lee, Giacomo Salvadore, Benjamin Hsu, Trehani M Fonseka, Sidney H Kennedy, Roger S McIntyre
Convergent evidence indicates that abnormalities in the innate immune system may be pertinent to the pathogenesis, phenomenology, and possible treatment of several mental disorders. In keeping with this view, the targeting of interleukin-6 with the human monoclonal antibody sirukumab may represent a possible treatment and disease modification approach, for adults with brain-based disorders (e.g., major depressive disorder). A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation...
January 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27891086/circuits-regulating-pleasure-and-happiness-mechanisms-of-depression
#5
Anton J M Loonen, Svetlana A Ivanova
According to our model of the regulation of appetitive-searching vs. distress-avoiding behaviors, the motivation to display these essential conducts is regulated by two parallel cortico-striato-thalamo-cortical, re-entry circuits, including the core and the shell parts of the nucleus accumbens, respectively. An entire series of basal ganglia, running from the caudate nucleus on one side, to the centromedial amygdala on the other side, controls the intensity of these reward-seeking and misery-fleeing behaviors by stimulating the activity of the (pre)frontal and limbic cortices...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27865949/lost-in-translation-the-potential-psychobiotic-lactobacillus-rhamnosus-jb-1-fails-to-modulate-stress-or-cognitive-performance-in-healthy-male-subjects
#6
John R Kelly, Andrew P Allen, Andriy Temko, William Hutch, Paul J Kennedy, Niloufar Farid, Eileen Murphy, Geraldine Boylan, John Bienenstock, John F Cryan, Gerard Clarke, Timothy G Dinan
BACKGROUND: Preclinical studies have identified certain probiotics as psychobiotics - live microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has been shown to reduce stress-related behaviour, corticosterone release and alter central expression of GABA receptors in an anxious mouse strain. However, it is unclear if this single putative psychobiotic strain has psychotropic activity in humans. Consequently, we aimed to examine if these promising preclinical findings could be translated to healthy human volunteers...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27836181/circadian-preferences-oxidative-stress-and-inflammatory-cytokines-in-bipolar-disorder-a-community-study
#7
Thaise Campos Mondin, Taiane de Azevedo Cardoso, Fernanda Pedrotti Moreira, Carolina Wiener, Jean Pierre Oses, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample...
December 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27830574/inflammation-effects-on-brain-glutamate-in-depression-mechanistic-considerations-and-treatment-implications
#8
Ebrahim Haroon, Andrew H Miller
There has been increasing interest in the role of glutamate in mood disorders, especially given the profound effect of the glutamate receptor antagonist ketamine in improving depressive symptoms in patients with treatment-resistant depression. One pathway by which glutamate alterations may occur in mood disorders involves inflammation. Increased inflammation has been observed in a significant subgroup of patients with mood disorders, and inflammatory cytokines have been shown to influence glutamate metabolism through effects on astrocytes and microglia...
2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27824355/neuropathology-of-mood-disorders-do-we-see-the-stigmata-of-inflammation
#9
REVIEW
N Mechawar, J Savitz
A proportion of cases with mood disorders have elevated inflammatory markers in the blood that conceivably may result from stress, infection and/or autoimmunity. However, it is not yet clear whether depression is a neuroinflammatory disease. Multiple histopathological and molecular abnormalities have been found postmortem but the etiology of these abnormalities is unknown. Here, we take an immunological perspective of this literature. Increases in activated microglia or perivascular macrophages in suicide victims have been reported in the parenchyma...
November 8, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27821270/bipolar-disorder-moderates-associations-between-linoleic-acid-and-markers-of-inflammation
#10
Ya-Wen Chang, Shervin Assari, Alan R Prossin, Laura Stertz, Melvin G McInnis, Simon J Evans
Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. We have previously reported that individuals with bipolar disorder (BPD) have decreased PUFA intake, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA); and decreased PUFA concentration of plasma EPA and linoleic acid (LA). We have also reported an association between plasma LA and its metabolites and burden of disease measures in BPD...
February 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27800654/biological-hypotheses-and-biomarkers-of-bipolar-disorder
#11
REVIEW
Ekaterina Sigitova, Zdeněk Fišar, Jana Hroudová, Tereza Cikánková, Jiří Raboch
The most common mood disorders are major depressive disorders and bipolar disorders. The pathophysiology of bipolar disorder is complex, multifactorial, and not fully understood. Creation of new hypotheses in the field gives impetus for studies and searching new biomarkers of the bipolar disorder. Conversely, new biomarkers facilitate not only diagnosis of a disorder and monitoring of biological effects of treatment, but also formulation of new hypotheses of the causes and pathophysiology of the bipolar disorder...
October 31, 2016: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/27744648/interleukin-1-%C3%AE-targeted-treatment-strategies-in-inflammatory-depression-toward-personalized-care
#12
P Ellul, L Boyer, L Groc, M Leboyer, G Fond
OBJECTIVES: It is unknown whether a cytokine signature may help the identification of subgroup of patient who would respond to personalized treatment. As interleukin-1 beta (Il-1β) seems to play a major role in mood disorder, a systematic review and meta-analysis of its potential role in major depressive disorder (MDD) was carried out. METHODS: A systematic search was performed to identify appropriate MDD vs. control studies pertaining to Il-1β. Methodological quality and possible moderators were also assessed...
December 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27730510/unpredictable-chronic-mild-stress-paradigm-established-effects-of-pro-and-anti-inflammatory-cytokine-on-neurodegeneration-linked-depressive-states-in-hamsters-with-brain-endothelial-damages
#13
Ennio Avolio, Gilda Fazzari, Maria Mele, Raffaella Alò, Merylin Zizza, Wei Jiao, Anna Di Vito, Tullio Barni, Maurizio Mandalà, Marcello Canonaco
The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it was our intention to establish the role of pro- and anti-inflammatory cytokine expression variations towards depression-like behaviors and consequently the development of neurodegeneration events caused by endothelial damages in the hamster (Mesocricetus auratus)...
October 11, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27718369/change-in-cytokine-levels-is-not-associated-with-rapid-antidepressant-response-to-ketamine-in-treatment-resistant-depression
#14
Minkyung Park, Laura E Newman, Philip W Gold, David A Luckenbaugh, Peixiong Yuan, Rodrigo Machado-Vieira, Carlos A Zarate
Several pro-inflammatory cytokines have been implicated in depression and in antidepressant response. This exploratory analysis assessed: 1) the extent to which baseline cytokine levels predicted positive antidepressant response to ketamine; 2) whether ketamine responders experienced acute changes in cytokine levels not observed in non-responders; and 3) whether ketamine lowered levels of pro-inflammatory cytokines, analogous to the impact of other antidepressants. Data from double-blind, placebo-controlled studies of patients with major depressive disorder (MDD) or bipolar disorder (BD) who received a single infusion of sub-anesthetic dose ketamine were used (N = 80)...
January 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27677784/role-of-neuro-immunological-factors-in-the-pathophysiology-of-mood-disorders-implications-for-novel-therapeutics-for-treatment-resistant-depression
#15
Anindya Bhattacharya, Wayne C Drevets
Mood disorders are associated with persistently high rates of morbidity and mortality, despite the widespread availability of antidepressant treatments. One limitation to extant therapeutic options has been that nearly all approved antidepressant pharmacotherapies exert a similar primary action of blocking monoamine transporters, and few options exist for transitioning treatment resistant patients to alternatives with distinct mechanisms. An emerging area of science that promises novel pathways to antidepressant and mood-stabilizing therapies has followed from evidence that immunological factors play major roles in the pathophysiology of at least some mood disorder subtypes...
2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27529630/prenatal-inflammation-infections-and-mental-disorders
#16
REVIEW
Eerika Flinkkilä, Anna Keski-Rahkonen, Mauri Marttunen, Anu Raevuori
BACKGROUND: The objective of this descriptive review is to summarize the current scientific evidence on the effect of prenatal exposure to maternal infection and immune response on the offspring's risk for mental disorders (schizophrenia spectrum disorders, autism spectrum disorders, attention-deficit hyperactivity disorder, anorexia nervosa, and mood disorders). SAMPLING AND METHODS: Studies were searched from PubMed and Ovid MEDLINE (R) databases with the following keywords: 'prenatal exposure delayed effects' and 'infection', and 'inflammation' and 'mental disorders'...
2016: Psychopathology
https://www.readbyqxmd.com/read/27432060/the-immune-system-and-the-role-of-inflammation-in-perinatal-depression
#17
REVIEW
Philippe Leff-Gelman, Ismael Mancilla-Herrera, Mónica Flores-Ramos, Carlos Cruz-Fuentes, Juan Pablo Reyes-Grajeda, María Del Pilar García-Cuétara, Marielle Danitza Bugnot-Pérez, David Ellioth Pulido-Ascencio
Major depression during pregnancy is a common psychiatric disorder that arises from a complex and multifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity...
August 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27412959/danger-signals-and-inflammasomes-stress-evoked-sterile-inflammation-in-mood-disorders
#18
Monika Fleshner, Matthew Frank, Steven F Maier
Major depressive disorder (MDD) and other mood disorders remain difficult to effectively treat, and innovative interventions and therapeutic targets are needed. Psychological stressors and inappropriate inflammation increase the risk and severity of mood disorders; however, only recently have the importance of sterile inflammatory processes in this effect been revealed. This review will introduce the reader to pathogen vs sterile inflammation, inflammatory receptor-ligand interactions, microbial-associated molecular patterns (MAMPs), pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and the more recent discovery of the role of the inflammasome in peripheral and central nervous system cytokine/chemokine inflammatory responses...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27344047/the-effect-of-mood-stabilizing-drugs-on-cytokine-levels-in-bipolar-disorder-a-systematic-review
#19
REVIEW
Seline van den Ameele, Linda van Diermen, Willem Staels, Violette Coppens, Glenn Dumont, Bernard Sabbe, Manuel Morrens
OBJECTIVES: Cytokine level alterations suggest a role for the immune system in the pathophysiology of bipolar disorder (BD). Pharmacotherapy is an important confounding factor in clinical research on cytokine levels. In this systematic review we collate the evidence on blood cytokine levels in medication-free BD and the effects of single mood-stabilizing drugs on these levels. METHODS: A systematic review was conducted according to the PRISMA statement. We searched the Pubmed and Embase databases for clinical studies reporting either on cytokine levels in medication-free BD or on the effects of single mood-stabilizing drugs on cytokine levels in BD...
October 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27291462/immune-and-neuroendocrine-mechanisms-of-stress-vulnerability-and-resilience
#20
Caroline Ménard, Madeline L Pfau, Georgia E Hodes, Scott J Russo
Diagnostic criteria for mood disorders including major depressive disorder (MDD) largely ignore biological factors in favor of behavioral symptoms. Compounding this paucity of psychiatric biomarkers is a need for therapeutics to adequately treat the 30-50% of MDD patients who are unresponsive to traditional antidepressant medications. Interestingly, MDD is highly prevalent in patients suffering from chronic inflammatory conditions, and MDD patients exhibit higher levels of circulating pro-inflammatory cytokines...
January 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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