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Pediatric febrile seizures

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https://www.readbyqxmd.com/read/29727742/cytokine-levels-in-febrile-seizure-patients-a-systematic-review-and-meta-analysis
#1
Aram Kwon, Byung Ok Kwak, Kyungmin Kim, Jongseok Ha, Soo-Jin Kim, Sun Hwan Bae, Jae Sung Son, Soo-Nyung Kim, Ran Lee
PURPOSE: Febrile seizures (FSs) are the most common form of childhood seizures. During infection, both pro-inflammatory and anti-inflammatory cytokines are produced. Complex interactions among immune-inflammatory process, cytokine activation, and genetic factors are involved in the pathogenesis of FSs. The association between cytokines and FSs during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between cytokines and FS in children...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29725488/serum-procalcitonin-levels-in-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#2
Yosuke Fujii, Masato Yashiro, Mutsuko Yamada, Tomonobu Kikkawa, Nobuyuki Nosaka, Yukie Saito, Kohei Tsukahara, Masanori Ikeda, Tsuneo Morishima, Hirokazu Tsukahara
Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF- α , and IFN- γ ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29461450/utility-of-the-performance-of-lumbar-puncture-for-febrile-children-with-status-epilepticus-in-the-bacterial-conjugate-vaccine-era
#3
Haro Kaoru, Ryota Igarashi, Takayuki Hoshina, Masumi Kojiro, Koichi Kusuhara
BACKGROUND: The necessity of lumbar puncture for the differentiation of central nervous system (CNS) infection in children with febrile status epilepticus (FSE) remains controversial. The aim of the present study is to investigate the diagnostic necessity of lumbar puncture for children with FSE after the introduction of bacterial conjugate vaccines into the infant immunization program. METHODS: Our retrospective cohort study was performed in children aged 6 to 60 months who were admitted to the pediatric ward at Kitakyushu General Hospital from January 1, 2011 to December 31, 2015 for seizures with fever...
February 15, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29456340/acute-febrile-encephalopathy-in-children-a-prospective-study-of-clinical-features-etiology-mortality-and-risk-factors-from-western-india
#4
Kirti Gupta, Charul S Purani, Anirban Mandal, Amitabh Singh
Introduction: Acute febrile encephalopathy (AFE) in children is a medical emergency and could be a manifestation of many systemic and central nervous system pathologies. The clinical features of AFE are nonspecific and etiological spectrum variable depending on the studied population. Materials and Methods: A prospective, observational study was carried out including children aged between 1 month and 12 years with AFE admitted to the Pediatric Intensive Care Unit of a tertiary care hospital in Western India...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29422395/diurnal-occurrence-of-complex-febrile-seizure-and-their-severity-in-pediatric-patients-needing-hospitalization
#5
Hiroshi Yamaguchi, Hiroaki Nagase, Yusuke Ishida, Daisaku Toyoshima, Azusa Maruyama, Kazumi Tomioka, Tsukasa Tanaka, Masahiro Nishiyama, Kyoko Fujita, Taniguchi-Ikeda Mariko, Kandai Nozu, Ichiro Morioka, Noriyuki Nishimura, Hiroshi Kurosawa, Satoshi Takada, Yoshiyuki Uetani, Kazumoto Iijima
Several studies describing the diurnal occurrence of febrile seizures have reported greater seizure frequency early or late in the evening relative to midnight or early morning. However, no articles have reported on the diurnal occurrence of complex febrile seizure. Moreover, no studies have addressed the relationship between seizure severity and diurnal occurrence. We retrospectively evaluated complex febrile seizures in 462 children needing hospitalization, and investigated the relationship between severity and diurnal occurrence according to four categorized time periods (morning, afternoon, evening, and night)...
March 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29379546/gabrg2-c588t-gene-polymorphisms-might-be-a-predictive-genetic-marker-of-febrile-seizures-and-generalized-recurrent-seizures-a-case-control-study-in-a-romanian-pediatric-population
#6
Anamaria Todoran Butilă, Ancuta Zazgyva, Anca Ileana Sin, Elisabeta Racoș Szabo, Mariana Cornelia Tilinca
Introduction: This case-control study aimed to assess two single nucleotide polymorphisms of the gene encoding the GABRG2 protein - GABRG2 (3145 G>A) and GABRG2 rs 211037 Asn196Asn (C588T) - in a cohort of pediatric patients from Romania, and evaluate their possible impact on drug-resistant forms of generalized epilepsy and recurrent febrile seizures. Material and methods: One hundred and fourteen children with idiopathic generalized epilepsy (group 1) or febrile seizures (group 2) were compared to 153 controls...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29356811/association-of-time-to-treatment-with-short-term-outcomes-for-pediatric-patients-with-refractory-convulsive-status-epilepticus
#7
Marina Gaínza-Lein, Iván Sánchez Fernández, Michele Jackson, Nicholas S Abend, Ravindra Arya, J Nicholas Brenton, Jessica L Carpenter, Kevin E Chapman, William D Gaillard, Tracy A Glauser, Joshua L Goldstein, Howard P Goodkin, Kush Kapur, Mohamad A Mikati, Katrina Peariso, Robert C Tasker, Dmitry Tchapyjnikov, Alexis A Topjian, Mark S Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper
Importance: Treatment delay for seizures can lead to longer seizure duration. Whether treatment delay is associated with major adverse outcomes, such as death, remains unknown. Objective: To evaluate whether untimely first-line benzodiazepine treatment is associated with unfavorable short-term outcomes. Design, Setting, and Participants: This multicenter, observational, prospective cohort study included 218 pediatric patients admitted between June 1, 2011, and July 7, 2016, into the 11 tertiary hospitals in the United States within the Pediatric Status Epilepticus Research Group...
April 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29317153/should-patients-with-complex-febrile-seizure-be-admitted-for-further-management
#8
Heather Olson, Tiffany Rudloe, Tobias Loddenkemper, Marvin B Harper, Amir A Kimia
BACKGROUND AND AIMS: Children with first complex febrile seizure (CFS) are often admitted for observation. The goals of this study were 1) to assess the risk of seizure recurrence during admission, 2) to determine whether early EEG affects acute management. DESIGN/METHODS: We retrospectively reviewed a cohort of children 6-60months of age admitted from a Pediatric Emergency Department for first CFS over a 15year period. We excluded children admitted for supportive care of their febrile illness...
December 28, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29229893/prognostic-factors-for-epilepsy-following-first-febrile-seizure-in-saudi-children
#9
Abdullah I Almojali, Anwar E Ahmed, Muhammed Y Bagha
BACKGROUND: Febrile seizure is the most common convulsive event during childhood, but it is generally considered benign. OBJECTIVES: To estimate the rate of epilepsy after first presentation of febrile seizure and to describe factors that can predispose children to have subsequent epilepsy after their first febrile seizure. DESIGN: Retrospective chart review. SETTING: A tertiary care center in Riyadh. PATIENTS AND METHODS: All children whose first febrile seizure developed between 2009-2012, and who were admitted to the pediatric wards...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29167084/parent-s-experiences-of-their-children-suffering-febrile-seizures
#10
Emma Westin, Märta Sund Levander
PURPOSE: To explore parents' experiences of their child suffering febrile seizures. DESIGN AND METHOD: Seven mothers and four fathers with experience of one or several febrile seizures in their children were interviewed. A qualitative content analysis with an inductive approach was performed. RESULT: Five themes emerged; emotional experiences, in terms of anxiety and fear, and need for control, need for support, need for acknowledgement and need for comfort...
January 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29141311/-study-on-mosaicism-of-scn1a-gene-mutation-in-parents-of-children-with-dravet-syndrome
#11
A J Liu, X X Yang, X J Xu, Q X Wu, X J Tian, X L Yang, X R Wu, L P Wei, Y H Zhang
Objective: To investigate the clinical phenotypes and the mutant allele proportion of parents with SCN1A gene mutation mosaicism of Dravet syndrome (DS) children, thus to provide guidance for family reproduction and prenatal diagnosis. Method: The clinical data and peripheral blood DNA samples of DS patients with a SCN1A gene mutation proved by Sanger sequencing were collected prospectively from February 2005 to November 2016 in Department of Pediatrics, Peking University First Hospital. The same mutation was searched in parents and other available relatives...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29127224/clinical-prediction-rule-for-neurological-sequelae-due-to-acute-encephalopathy-a-medical-community-based-validation-study-in-harima-japan
#12
Kaori Sasaki, Hiroaki Nagase, Azusa Maruyama, Kyoko Fujita, Masahiro Nishiyama, Tsukasa Tanaka, Sadayuki Nukina, Toru Takumi, Kanae Takenaka, Yoshinobu Oyazato, Atsushi Nishiyama, Tomoko Kawata, Keisuke Saeki, Yuichi Takami, Eriko Satake-Inoue, Kazumoto Iijima, Ichiro Morioka, Yoshiyuki Uetani
OBJECTIVES: This study aimed to verify the screening performance of our clinical prediction rule for neurological sequelae due to acute encephalopathy (NSAE-CPR), which previously identified the following three variables as predictive of poor outcomes: (1) refractory status epilepticus; (2) consciousness disturbance and/or hemiplegia at 6 hours from onset and (3) aspartate aminotransferase >90 IU/L within 6 hours of onset. DESIGN: Medical community-based multicentre retrospective cohort study...
November 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/29119032/cytomegalovirus-associated-duodenal-ulcer-and-duodenitis-in-a-malnourished-pediatric-patient
#13
Rachel Bernard, Ghanim Aljomah, Emily Klepper, Elizabeth McDonough
Cytomegalovirus (CMV) duodenitis is a rare occurrence, especially in pediatric patients. A thirteen-month-old female presented to the Emergency Department for a febrile seizure. She was incidentally admitted for severe malnutrition with an initial workup remarkable for only a slight elevation in her ALT at 48. The patient was found to have an oral aversion requiring nasogastric tube feeds for adequate caloric intake. She continued to fail to gain weight and underwent an EGD that demonstrated a duodenal ulcer...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29042874/serum-neuron-specific-enolase-is-increased-in-pediatric-acute-encephalitis-syndrome
#14
Dian Pratamastuti, Prastiya Indra Gunawan, Darto Saharso
PURPOSE: This study aimed to investigate whether serum neuron-specific enolase (NSE) was expressed in acute encephalitis syndrome (AES) that causes neuronal damage in children. METHODS: This prospective observational study was conducted in the pediatric neurology ward of Soetomo Hospital. Cases of AES with ages ranging from 1 month to 12 years were included. Cases that were categorized as simple and complex febrile seizures constituted the non-AES group. Blood was collected for the measurement of NSE within 24 hours of hemodynamic stabilization...
September 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28957722/relationship-between-iron-deficiency-anemia-and-febrile-seizures-in-children-a-systematic-review-and-meta-analysis
#15
Byung Ok Kwak, Kyungmin Kim, Soo-Nyung Kim, Ran Lee
PURPOSE: The association between iron deficiency anemia (IDA) and febrile seizures (FS) during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between IDA and FS in children. METHODS: We searched PubMed, EMBASE, and Cochrane Library databases for studies published up to August 2015 using the following key words: ["iron deficiency" OR "iron status"] AND ["febrile seizure" OR "febrile convulsion"] AND ["pediatric" OR "infant" OR "child"]...
November 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28808794/thiol-disulfide-homeostasis-as-a-novel-indicator-of-oxidative-stress-in-children-with-simple-febrile-seizures
#16
Bahri Elmas, Özcan Erel, Dilek Ersavaş, Yusuf Yürümez
Simple febrile seizures are generally benign, but during the seizure, elevated levels of glutamate and high levels of oxygen use due to the high metabolic brain activity result in oxidative stress. However, the relationship between febrile seizures and oxidative stress remains unclear. In this study, we investigated thiol/disulfide homeostasis as a new oxidative stress parameter in patients with simple febrile seizures. This study was performed between February 2016 and May 2016 at the Pediatric Emergency Unit...
November 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28763650/the-effects-of-weather-on-pediatric-seizure-a-single-center-retrospective-study-2005-2015
#17
Sung Hoon Kim, Joon Soo Kim, Mi Hyeon Jin, Jun Hwa Lee
BACKGROUND: Several studies have reported an association between seizure and the weather. However, reports are conflicting. Thus, we investigated whether emergency department visits due to seizure are affected by weather. METHODS: We retrospectively analyzed 108,628 emergency department visits to Samsung Changwon Hospital by pediatric patients from January 2005 to December 2015. Among them, there were 3484 (3.2%) visits for any type of seizure. Seizures were categorized as febrile seizure, afebrile seizure, epilepsy, or status epilepticus...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551342/r-scan-imaging-for-pediatric-simple-febrile-seizures
#18
Sarah Lee, Paul Fisher, Gerald A Grant, Brenda Porter, Bernard Dannenberg, Max Wintermark
No abstract text is available yet for this article.
August 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28509667/evaluation-of-hippocampal-infolding-angle-and-incomplete-hippocampal-inversion-in-pediatric-patients-with-epilepsy-and-febrile-seizures
#19
Mehtap Beker Acay, Reşit Köken, Ebru Ünlü, Emre Kaçar, Çınar Balçık
PURPOSE: We aimed to investigate the frequency of incomplete hippocampal inversion (IHI) and the hippocampal infolding angle (HIA) in pediatric patients with no additional abnormal findings in the brain. METHODS: Pediatric brain magnetic resonance imaging (MRI) examinations conducted between September 2012 and February 2015 were screened and 83 patients with epilepsy, 49 patients with febrile convulsion, and 74 control patients were included in this retrospective study...
July 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28482763/clinical-characteristics-and-risk-factors-for-seizures-associated-with-norovirus-gastroenteritis-in-childhood
#20
Mei-Hua Hu, Kuang-Lin Lin, Chang-Teng Wu, Shih-Yen Chen, Go-Shine Huang
Norovirus has become increasingly recognized as causing viral gastroenteritis in children. Few data are available on the characteristics of children admitted to pediatric emergency departments with norovirus gastroenteritis and accompanying seizures. Our aim in this study was to describe the clinical features of, and risk factors for, seizures accompanying norovirus gastroenteritis. We collected 6359 stool samples from patients with gastroenteritis, of whom 1444 (22.71%) had laboratory-confirmed norovirus gastroenteritis...
August 2017: Journal of Child Neurology
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