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https://www.readbyqxmd.com/read/28820183/technique-of-retinal-gene-therapy-delivery-of-viral-vector-into-the-subretinal-space
#1
K Xue, M Groppe, A P Salvetti, R E MacLaren
PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene therapy technique involved pre-operative planning with optical coherence tomography (OCT) and autofluorescence (AF) imaging, 23 G pars plana vitrectomy, internal limiting membrane staining with Membrane Blue Dual (DORC BV, Zuidland, Netherlands), a two-step subretinal injection using a 41 G Teflon tipped cannula (DORC) first with normal saline to create a parafoveal bleb followed by slow infusion of viral vector via the same self-sealing retinotomy...
August 18, 2017: Eye
https://www.readbyqxmd.com/read/28814417/intravitreal-bevacizumab-monotherapy-in-myopic-choroidal-neovascularisation-5-year-outcomes-for-the-pan-american-collaborative-retina-study-group
#2
Jay Chhablani, Remya Mareen Paulose, Andres F Lasave, Lihteh Wu, Cristian Carpentier, Mauricio Maia, Silvio Lujan, Sergio Rojas, Martin Serrano, Maria H Berrocal, J Fernando Arevalo
PURPOSE: To report the long-term anatomical and visual outcomes of intravitreal bevacizumab (IVB) monotherapy in naive choroidal neovascularisation (CNV) caused by myopia. METHODS: Retrospective analysis of naive CNV secondary to myopia that underwent antivascular endothelial growth factor monotherapy was performed. Collected data included demographic details, clinical examination details including visual acuity at presentation and follow-up with imaging and treatment details...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28810040/vascular-density-of-retinal-capillary-plexuses-in-different-subtypes-of-macular-hole
#3
Luisa Pierro, Alessandro Rabiolo, Lorenzo Iuliano, Marco Gagliardi, Davide Panico, Francesco Bandello
BACKGROUND AND OBJECTIVE: To compare vessel density and the foveal avascular zone (FAZ) area among eyes with full-thickness macular hole (FTMH), lamellar macular hole (LMH), and macular pseudohole (MPH) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional study involving 10 eyes with idiopathic FTMH, 10 eyes with LMH, 10 eyes with MPH, 17 unaffected fellow eyes, and 10 healthy controls. All patients underwent 3 mm × 3 mm OCTA centered on the macula...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28810036/evaluation-of-macular-perfusion-in-healthy-smokers-by-using-optical-coherence-tomography-angiography
#4
Ziya Ayhan, Mahmut Kaya, Taylan Ozturk, Omer Karti, F Hakan Oner
BACKGROUND AND OBJECTIVE: To investigate the macular perfusion changes in healthy smokers by using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: OCTA measurements were taken for the right eyes of 40 smokers (Group 1) and age- and sex-matched control cases (Group 2). Group 1 underwent OCTA scanning with the XR Avanti AngioVue OCTA (Optovue, Fremont, CA) at baseline and at 5 minutes, 30 minutes, and 60 minutes after one standard cigarette smoking...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28808926/foveal-microstructure-analysis-in-eyes-with-diabetic-macular-edema-treated-with-vitrectomy
#5
Jiro Kogo, Akira Shiono, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Yasushi Kitaoka, Hitoshi Takagi
INTRODUCTION: The purpose of this study was to evaluate baseline and postoperative factors affecting outcomes after vitrectomy for diabetic macular edema (DME) using optical coherence tomography (OCT). METHODS: Vitrectomy combined with inner limiting membrane (ILM) peeling and additional laser photocoagulation therapy was performed on 36 eyes of 30 DME patients. Evaluations included the logarithm of the minimal angle of resolution (logMAR), best-corrected visual acuity (BCVA) and OCT parameters at baseline and 1, 3, 6, and 12 months postoperatively...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28794900/structure-versus-function-correlation-between-outer-retinal-and-choroidal-thicknesses-measured-by-swept-source-oct-with-multifocal-electroretinography-and-visual-acuity
#6
Ignacio Flores-Moreno, Luis Arias-Barquet, Marcos J Rubio-Caso, Alex Muñoz-Blanco, María Vidal-Martí, Jaume Catala-Mora, José M Ruiz-Moreno, Jay S Duker, Josep M Caminal
BACKGROUND: To correlate retina-choroidal anatomy as assessed via swept-source OCT (SS-OCT) with retinal function as determined by best-corrected visual acuity (BCVA) and multifocal electroretinogram (mfERG). METHODS: Thirty-three eyes from 33 patients including 16 with neovascular AMD (nvAMD) and 17 controls were included. Patients were included in the present study after a complete ophthalmologic examination, including BCVA, slit-lamp study, intraocular pressure measurement, dilated fundus examination after tropicamide instillation, SD-OCT, SS-OCT, fundus photographs and mfERG...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28781889/evaluation-of-macular-and-peripapillary-vessel-flow-density-in-eyes-with-no-known-pathology-using-optical-coherence-tomography-angiography
#7
Muhammad Hassan, Mohammad Ali Sadiq, Muhammad Sohail Halim, Rubbia Afridi, Mohamed K Soliman, Salman Sarwar, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir Jamal Sepah
PURPOSE: To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). METHODS: AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 × 3 mm grid and a 4.5 × 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors within the inner two circles of ETDRS grid in macular region and correlated to retinal thickness of same sectors...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28769551/intravitreal-aflibercept-for-choroidal-neovascularization-associated-with-chorioretinitis-a-pilot-study
#8
Andrii R Korol, Oleksandra Zborovska, Taras Kustryn, Oleksandra Dorokhova, Nataliya Pasyechnikova
PURPOSE: The purpose of this study was to evaluate the potential benefits of intravitreal aflibercept injections for the treatment of choroidal neovascularization (CNV) secondary to chorioretinitis. METHODS: In this uncontrolled, prospective cohort study, 15 eyes of 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were treated with intravitreal aflibercept (2 mg) pro re nata and observed over a 12-month follow-up period. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to month 12...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28767555/foveal-avascular-zone-area-after-internal-limiting-membrane-peeling-for-epiretinal-membrane-and-macular-hole-compared-with-that-of-fellow-eyes-and-healthy-controls
#9
Kazuyuki Kumagai, Mariko Furukawa, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To measure the foveal avascular zone (FAZ) area after internal limiting membrane (ILM) peeling and to determine the factors significantly correlated with the FAZ area. METHODS: This was a retrospective, observational, and cross-sectional study. The affected and normal fellow eyes of 102 patients with unilateral macular diseases and 169 healthy subjects were studied. The patients underwent successful vitrectomy with internal limiting membrane peeling for an epiretinal membrane (n = 56) or a macular hole (n = 46)...
August 1, 2017: Retina
https://www.readbyqxmd.com/read/28767552/efficacy-and-frequency-of-intravitreal-aflibercept-versus-bevacizumab-for-macular-edema-secondary-to-central-retinal-vein-occlusion
#10
Ayman Lotfy, Kamal A M Solaiman, Ayman Abdelrahman, Ahmed Samir
PURPOSE: To compare the safety, efficacy, and frequency of intravitreal injection of aflibercept and bevacizumab for treatment of macular edema secondary to central retinal vein occlusion. DESIGN: Prospective, comparative, randomized, interventional study. PATIENTS AND METHODS: Eyes with macular edema secondary to central retinal vein occlusion were randomized between two groups according to the intravitreal injection used. Group A included eyes treated with intravitreal aflibercept, and Group B included eyes treated with intravitreal bevacizumab injections...
August 1, 2017: Retina
https://www.readbyqxmd.com/read/28766280/influence-of-glycosylated-hemoglobin-on-the-choroidal-thickness
#11
Nedime Sahinoglu-Keskek, Rana Altan-Yaycioglu, Handan Canan, Muge Coban-Karatas
PURPOSE: The aim of the study reported here was to assess the influence of serum HbA1c levels on foveal choroidal thickness in diabetic patients. METHODS: A total of 122 eyes from 122 patients who had type 2 DM were studied in this prospective, cross-sectional study. Patients were divided into three groups: 43 patients (43 eyes) without diabetic retinopathy (NDR), 39 patients (39 eyes) with diabetic retinopathy and no macular edema (DR/ME-), 40 patients (40 eyes) with diabetic retinopathy and macular edema (DR/ME+)...
August 1, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28763558/radiation-maculopathy-after-proton-beam-therapy-for-uveal-melanoma-optical-coherence-tomography-angiography-alterations-influencing-visual-acuity
#12
Alexandre Matet, Alejandra Daruich, Leonidas Zografos
Purpose: To analyze microvascular and structural changes in radiation maculopathy and their influence on visual acuity (VA), using optical coherence tomography (OCT) and OCT angiography (OCTA). Methods: This was a retrospective analysis of consecutive patients with radiation maculopathy, 12 months or more after proton-beam irradiation for uveal melanoma, imaged with fluorescein angiography, OCT, and OCTA. Clinical parameters potentially affecting VA were recorded, including OCTA-derived metrics: foveal avascular zone (FAZ) area, vascular density, and local fractal dimension of the superficial (SCP) and deep capillary plexuses (DCP)...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28756595/structural-and-functional-assessment-after-intravitreal-injection-of-ranibizumab-in-diabetic-macular-edema
#13
YuDong Fu, Ping Wang, XuXia Meng, Zhaodong Du, DaBo Wang
PURPOSE: To evaluate structure and function improvement in central retina by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) in diabetic macular edema (DME) patients after intravitreal injection of ranibizumab (IVR) treatment. METHODS: Twenty-seven eyes in 27 patients with DME received three consecutive monthly injections of IVR (0.05 ml, 10 mg/ml) and as needed thereafter. The clinical parameters of best-corrected visual acuity (BCVA), central foveal thickness (CFT) and mf-ERG were monitored for 6 months before and after IVR...
July 29, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28754419/evaluation-of-tolerance-to-lentiviral-lv-rpe65-gene-therapy-vector-after-subretinal-delivery-in-nonhuman-primates
#14
Alexandre Matet, Corinne Kostic, Alexis-Pierre Bemelmans, Alexandre Moulin, Serge G Rosolen, Samia Martin, Fulvio Mavilio, Vazrik Amirjanians, Knut Stieger, Birgit Lorenz, Francine Behar-Cohen, Yvan Arsenijevic
Several approaches have been developed for gene therapy in RPE65-related Leber congenital amaurosis. To date, strategies that have reached the clinical stages rely on adeno-associated viral vectors and 2 of them documented limited long-term effect. We have developed a lentiviral-based strategy of RPE65 gene transfer that efficiently restored protein expression and cone function in RPE65-deficient mice. In this study, we evaluated the ocular and systemic tolerances of this lentiviral-based therapy (LV-RPE65) on healthy nonhuman primates (NHPs), without adjuvant systemic anti-inflammatory prophylaxis...
July 8, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28744658/characteristics-of-retinal-vessels-in-surgically-closed-macular-hole-an-optical-coherence-tomography-angiography-study
#15
Cheolmin Yun, Jaemoon Ahn, Mingue Kim, Jee Taek Kim, Soon-Young Hwang, Seong-Woo Kim, Jaeryung Oh
PURPOSE: The purpose of our study was to investigate characteristics of retinal vessels in eyes with surgically closed macular holes (MH). METHODS: We included patients who underwent surgery for idiopathic MH and a follow-up examination using optical coherence tomography angiography (OCTA). The area of the foveal avascular zone (FAZ) and retinal vascular densities of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were calculated on the postoperative OCTA images and compared with those of age-matched normal controls...
July 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28742138/long-term-prognostic-factors-of-chronic-central-serous-chorioretinopathy-after-half-dose-photodynamic-therapy-a-3-year-follow-up-study
#16
Fuminori Haga, Ruka Maruko, Chiaki Sato, Keiko Kataoka, Yasuki Ito, Hiroko Terasaki
PURPOSE: To evaluate the long-term efficacy and factors involved in the recurrence and persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective observational case series, 79 eyes (73 patients) with chronic CSC were treated with half-dose PDT and followed up for at least 3 years. They were divided into successful (64 eyes) and unsuccessful (15 eyes) groups based on SRF absorption and disease recurrence after one PDT session...
2017: PloS One
https://www.readbyqxmd.com/read/28740734/effect-of-topical-nepafenac-on-central-foveal-thickness-following-panretinal-photocoagulation-in-diabetic-patients
#17
Nahla B Abu Hussein, Ahmed A Mohalhal, Dalia A Ghalwash, Ahmed A Abdel-Kader
PURPOSE: To evaluate effectiveness of topical nepafenac in reducing macular edema following panretinal photocoagulation (PRP). DESIGN: Prospective randomized double-blinded controlled study. METHODS: Sixty eyes of 60 patients having proliferative or severe nonproliferative diabetic retinopathy had PRP. Patients were then divided into two groups: nepafenac group (30 eyes) receiving 1% topical nepafenac eye drops for 6 months and control group (30 eyes) receiving carboxymethylcellulose eye drops for 6 months...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28731058/multicenter-study-of-pars-plana-vitrectomy-for-optic-disc-pit-maculopathy-macpit-study
#18
R Avci, Z Kapran, Ş Ozdek, M Y Teke, O Oz, D Guven, S Yilmaz, B Kaderli, A H Durukan, G Sobaci, Y B Unver, L Akduman, S Kaynak, I Dogan, U U Inan
PurposeTo evaluate surgical intervention with pars plana vitrectomy (PPV) for correction of optic disc pit maculopathy (ODP-M).Patients and methodsRetrospective chart review from 13 centres of 51 eyes of 50 patients with ODP-M who underwent PPV between 2002-2014. Anatomic and final best-corrected visual acuity (BCVA) outcomes were evaluated for all cases with different adjuvant techniques.ResultsThere were 23 males and 27 females with median age 25.5 (6-68) years. Preoperative median foveal thickness was 694...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28731057/idiopathic-macular-holes-and-direction-of-vitreomacular-traction-structural-changes-and-surgical-outcomes
#19
C-Y Tsai, Y-T Hsieh, T-T Lai, C-M Yang
PurposeTo compare the structural changes, clinical course, and treatment outcomes of vertical and horizontal vitreomacular traction (VMT) induced impending macular holes (IMHs) and full-thickness macular holes (FTMHs).MethodsIn this retrospective study, 23 and 32 cases of IMHs and FTMHs, respectively, were analyzed. The IMH cases were divided into two subgroups: IMH with and without foveal detachment. Vitreofoveal traction angles (TAs) between the inner retinal surface and posterior hyaloid were measured from horizontal and vertical optical coherence tomography (OCT) images by using the trigonometric function (the angle equals the arctangent of the height over the base) after adjustments for magnification factors...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28729371/geographic-atrophy-phenotype-identification-by-cluster-analysis
#20
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
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