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https://www.readbyqxmd.com/read/28108904/intravitreal-anti-vegf-treatment-for-subretinal-neovascularisation-secondary-to-type-2-idiopathic-juxtafoveolar-telangiectasia
#1
Teresa Barth, Florian Zeman, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: To assess the long-term outcome of patients with subretinal neovascular membrane (SRNVM) secondary to type 2 idiopathic juxtafoveolar telangiectasia (IJT) receiving intravitreal anti-VEGF (vascular endothelial growth factor) injections. METHODS: A total of 14 eyes of 12 patients treated with intravitreal anti-VEGF for SRNVM related to type 2 IJT were retrospectively assessed. RESULTS: Nine men and 3 women with a mean age of 66 years (SD 12, range 47-87 years) were diagnosed with IJT-related SRNVM...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28105123/effect-of-anti-vegf-drugs-combined-with-photodynamic-therapy-in-the-treatment-of-age-related-macular-degeneration
#2
Yi Dong, Guangming Wan, Panshi Yan, Yue Chen, Wenzhan Wang, Guanghua Peng
We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28098736/foveal-exudate-and-choroidal-neovascularization-in-atypical-cases-of-multiple-evanescent-white-dot-syndrome
#3
Kevin C Chen, Marcela Marsiglia, Rosa Dolz-Marco, Sarwar Zahid, Sarah Mrejen, Jose S Pulido, Salomon Y Cohen, Benjamin Freilich, Lawrence A Yannuzzi, K Bailey Freund
PURPOSE: To describe atypical cases of multiple evanescent white dot syndrome (MEWDS) associated with foveal exudation, increased choroidal thickness, and secondary Type 2 (subretinal) neovascularization. METHODS: Four cases of atypical MEWDS were studied at a retina referral center. Patients underwent evaluation with multimodal retinal imaging, including fluorescein angiography, indocyanine green angiography, spectral-domain and enhanced depth imaging optical coherence tomography (OCT)...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098735/optical-coherence-tomography-angiography-of-the-fovea-in-children-born-preterm
#4
Khalil Ghasemi Falavarjani, Nicholas A Iafe, Federico G Velez, Steven D Schwartz, Srinivas R Sadda, David Sarraf, Irena Tsui
PURPOSE: To compare the foveal avascular zone (FAZ) area measured by optical coherence tomography angiography in children who had been born preterm with age-matched controls. METHODS: In this cross-sectional observational comparative case series, 43 eyes of 26 children (28 eyes of 15 former preterm infants and 15 eyes of 11 former term infants) between the ages of 4 and 12 years old were included. Optical coherence tomography angiography with a scan size of 3 × 3 was performed for all eyes...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098725/how-vitreomacular-interface-modifies-the-efficacy-of-anti-vegf-therapy-for-myopic-choroidal-neovascularization
#5
Pierluigi Iacono, Maurizio Battaglia Parodi, Lorenzo Iuliano, Francesco Bandello
PURPOSE: To evaluate the efficacy of intravitreal ranibizumab in the treatment of myopic choroidal neovascularization (mCNV) complicated by vitreoretinal interface alterations. METHODS: Thirty-two patients affected by mCNV and concurrent vitreoretinal interface disorders, including macular epiretinal membrane (18 patients), lamellar macular hole (4 patients), full-thickness macular hole (1 patient), broad/focal vitreomacular traction (3 patients), broad/focal vitreomacular adhesion (4 patients), and myopic foveoschisis (2 patients), were enrolled in a prospective study...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28092342/integrity-of-outer-retinal-layers-after-resolution-of-central-involved-diabetic-macular-edema
#6
Ilkay Kilic Muftuoglu, Nadia Mendoza, Raouf Gaber, Mostafa Alam, Qisheng You, William R Freeman
PURPOSE: To evaluate the integrity of outer retina layers after resolution of central involved diabetic macular edema (DME) and to demonstrate the effect of various baseline factors for the final vision and final external limiting membrane (ELM) integrity. METHODS: Fifty-nine eyes of 48 patients with resolved DME were included. Several optical coherence tomography parameters including central subfield thickness, maximum foveal thickness, foveal center point thickness, and the extent of the ellipsoidal (ISe) layer and ELM damage were assessed at the time of DME and after resolution of DME...
January 13, 2017: Retina
https://www.readbyqxmd.com/read/28089219/prognostic-factors-of-epiretinal-membranes-a-systematic-review
#7
REVIEW
A I M Miguel, A Legris
INTRODUCTION: Epiretinal membranes (ERM) have been increasingly characterized with the advent of new optical coherence tomographies (OCTs). We intended to perform a systematic review regarding prognostic factors (PF) of ERM after surgery. MATERIALS AND METHODS: Systematic review of electronic databases was performed (last date of search was 10 August 2015): Medline, Scopus, Google Scholar, clinicaltrials.gov and current controlled trials. Search queries included: "membrane", "pucker", "prognosis", "prognostic", "epiretinal", "épirétinienne"...
January 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28068388/the-association-between-foveal-morphology-and-macular-pigment-spatial-distribution-an-ethnicity-study
#8
Irene Ctori, Byki Huntjens
PURPOSE: Macular pigment (MP) spatial distribution varies considerably among individuals. We investigated ethnic variations in MP spatial distribution in relation to foveal architecture. METHODS: We measured MP optical density (MPOD) using heterochromatic flicker photometry (MAP test, City, University of London) in 76 white, 80 South Asian and 70 black volunteers (18 to 39 years). MPOD spatial profiles were classified objectively as exponential, ring-like or central dip, based on deviations away from an exponential fit...
2017: PloS One
https://www.readbyqxmd.com/read/28057647/characterisation-of-choroidal-morphological-and-vascular-features-in-diabetes-and-diabetic-retinopathy
#9
Preeti Gupta, Sri Gowtham Thakku, Charumathi Sabanayagam, Gavin Tan, Chui Ming Gemmy Cheung, Ecosse L Lamoureux, Tien-Yin Wong, Ching-Yu Cheng
AIM: We aimed to characterise specific morphological and vascular features of the choroid in Indian adults with diabetes and diabetic retinopathy (DR). METHODS: Consecutive participants from the Singapore Indian Eye Study's 6-year follow-up examination underwent choroidal imaging using spectral domain optical coherence tomography (OCT) with enhanced depth imaging. Raw OCT images were loaded on a custom-written application on MATLAB that enabled delineation for detailed morphological and vascular analyses...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28053499/chronic-central-serous-chorioretinopathy-long-term-follow-up-and-vision-related-quality-of-life
#10
Myrte B Breukink, Alexander Jm Dingemans, Anneke I den Hollander, Jan Ee Keunen, Robert E MacLaren, Sascha Fauser, Giuseppe Querques, Carel B Hoyng, Susan M Downes, Camiel Jf Boon
PURPOSE: To describe the clinical findings and long-term outcome of patients with chronic central serous chorioretinopathy (cCSC). MATERIALS AND METHODS: This was a retrospective case series in 52 eyes of 36 patients with a follow-up period of at least 1 year. Extensive ophthalmic examination and a validated questionnaire concerning vision-related quality of life (National Eye Institute Visual Function Questionnaire [NEI-VFQ]-39) were analyzed. RESULTS: Mean visual acuity showed a significant decline over time of 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28043309/visual-and-anatomical-outcomes-following-idiopathic-macular-epiretinal-membrane-surgery
#11
Bashiran Shahzadi, Syed Fawad Rizvi, Kanwal Latif, Faisal Murtaza, Saliha Naz
OBJECTIVE: To assess the visual and anatomical outcomes following idiopathic macular epiretinal membrane (IERM) surgery. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Layton Rehmatulla Benevolent Trust (L.R.B.T), Free Base Eye Hospital, Karachi, from January 2015 to June 2016. METHODOLOGY: Thirty eyes of thirty patients affected with idiopathic macular epiretinal membrane stage 2 were enrolled in this study...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28042632/macular-thickness-in-healthy-saudi-adults-a-spectral-domain-optical-coherence-tomography-study
#12
Waseem M Al-Zamil, Fahad M Al-Zwaidi, Sanaa A Yassin
To determine the macular thickness in the eyes of healthy Saudi adults using spectral-domain optical coherence tomography (SD-OCT). Methods: This is a prospective, cross-sectional study, including 158 healthy participants between August and December 2015. Mean subject age was 29.9 ± 7.85 years old. All participants underwent full ophthalmic evaluation, including SD-OCT imaging, and axial length measurement. Data from the right eye were included. Mean retinal thickness was determined. Correlations between retinal thickness and gender, age, axial length, and spherical equivalence were analyzed...
January 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28033234/associations-between-macular-edema-and-circulatory-status-in-eyes-with-retinal-vein-occlusion-an-adaptive-optics-scanning-laser-ophthalmoscopy-study
#13
Yuto Iida, Yuki Muraoka, Akihito Uji, Sotaro Ooto, Tomoaki Murakami, Kiyoshi Suzuma, Akitaka Tsujikawa, Shigeta Arichika, Ayako Takahashi, Yuko Miwa, Nagahisa Yoshimura
PURPOSE: To investigate associations between parafoveal microcirculatory status and foveal pathomorphology in eyes with macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: Ten consecutive patients (10 eyes) with acute retinal vein occlusion were enrolled, 9 eyes of which received intravitreal ranibizumab (IVR) injections. Foveal morphologic changes were examined via optical coherence tomography (OCT), and parafoveal circulatory status was assessed via adaptive optics scanning laser ophthalmoscopy (AO-SLO)...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28031700/long-term-results-of-combination-therapy-using-anti-vegf-agents-and-dexamethasone-intravitreal-implant-for-retinal-vein-occlusion-an-investigational-case-series
#14
Michael A Singer, Michael E Jansen, Lyndon Tyler, Paul Woods, Faisal Ansari, Udit Jain, Joshua Singer, Darren Bell, Chelsey Krambeer
BACKGROUND: One limitation of anti-VEGF therapy is the need for monthly retreatment to maintain efficacy. The purpose of this study was to determine the duration of effect in eyes with macular edema (ME) secondary to branch or central retinal vein occlusion (BRVO or CRVO) treated with anti-VEGF therapy plus sustained-release dexamethasone (DEX implant; Ozurdex). MATERIALS AND METHODS: This open-label, interventional case series included 62 eyes with ME due to RVO, central foveal thickness (CFT) >300 μm, and best-corrected visual acuity (BCVA) of 20/40 or worse...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28028626/migraine-causes-retinal-and-choroidal-structural-changes-evaluation-with-ocular-coherence-tomography
#15
Ester Reggio, Clara G Chisari, Giulia Ferrigno, Francesco Patti, Giulia Donzuso, Giorgia Sciacca, Teresio Avitabile, Salvatore Faro, Mario Zappia
Few studies have evaluated whether the retina is involved in migraine through the evaluation of retinal nerve fiber layer (RNFL) examined with ocular coherence tomography (OCT) with conflicting results. Aim of this case-control study is to evaluate the retina and the choroid in migraine. Patients having migraine with aura (MwA) or without aura (MoA) and chronic migraine (CM) were evaluated. Age- and sex-matched normal subjects were selected as healthy controls (HC). Patients and HC were examined with OCT. RNFL, ganglion cell layer (GCL), foveal thickness (FT), choroidal thickness (CT) and total macular volume (TMV) were calculated for right eyes (RE) and left eyes (LE)...
December 27, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/28009415/dexamethasone-intravitreal-implant-at-the-time-of-cataract-surgery-in-eyes-with-diabetic-macular-edema
#16
Giacomo A Panozzo, Elena Gusson, Giorgio Panozzo, Giulia Dalla Mura
PURPOSE: To determine the potential role of intraoperative dexamethasone intravitreal implant (DEX-I) in reducing diabetic macular edema (DME) worsening after phacoemulsification. METHODS: This was a prospective study on 19 eyes of 19 patients with type 2 diabetes mellitus with DME and cataract. Mean preoperative Early Treatment Diabetic Retinopathy Study visual acuity (VA) was 16.7 letters. Mean foveal thickness (FT) was 451 μm. The DME was naive in 11 eyes and refractory in 8 eyes...
December 16, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003781/evaluation-of-the-acute-effect-of-haemodialysis-on-retina-and-optic-nerve-with-optical-coherence-tomography
#17
Sinan Emre, Anıl Öztürkeri, Mahmut Oğuz Ulusoy, Cem Cankurtaran
PURPOSE: The primary objective of haemodialysis (HD) was to correct the composition and volume of body fluids. The aim of this study was to evaluate the acute effect of HD on mean arterial pressure changes and on retina and optic nerve with optical coherence tomography (OCT). METHODS: Fifty-three eyes of 28 patients were enrolled in this study. The patients' retinal and RNFL thicknesses were measured by OCT and mean arterial pressure alterations were recorded before and immediately after HD session...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28003780/aflibercept-in-refractory-wet-amd-treated-with-ranibizumab-anatomical-and-visual-outcome
#18
Sleiman Abou-Ltaif
PURPOSE: To assess the anatomical outcome of patients with exudative age-related macular degeneration resistant to ranibizumab treated with aflibercept. METHOD: Prospective, interventional, case series, where we treated a group of patients deemed resistant to Ranibizumab after 6 months of persistence of intra- or subretinal fluid despite continuous treatment. RESULTS: The study included 17 patients, 3 males and 14 females. The average males age was 85 (range 83-87), and that of females was 79...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27997512/variability-in-foveal-avascular-zone-and-capillary-density-using-optical-coherence-tomography-angiography-machines-in-healthy-eyes
#19
George N Magrath, Emil Anthony T Say, Kareem Sioufi, Sandor Ferenczy, Wasim A Samara, Carol L Shields
PURPOSE: To evaluate the variability in foveal avascular zone (FAZ) and capillary density measurements on optical coherence tomography angiography using Optovue RTVue XR Avanti (OA) (Optovue) and Zeiss Cirrus HD-OCT 5000 (ZC) (Carl Zeiss Meditec). METHODS: In this prospective, comparative case series, parafoveal (3 × 3 mm) optical coherence tomography angiography scans were obtained on healthy volunteers using both the Avanti and Cirrus. The FAZ area and capillary density at the level of both the superficial and deep capillary plexus were measured automatically using the built-in ReVue software (Optovue) with the Avanti as well as manually using ImageJ (National Institutes of Health) with both machines...
December 16, 2016: Retina
https://www.readbyqxmd.com/read/27997459/short-term-findings-on-optical-coherence-tomography-and-microperimetry-in-chronic-central-serous-chorioretinopathy-patients-treated-with-half-dose-photodynamic-therapy
#20
Elon H C van Dijk, Greet Dijkman, Thomas Theelen, Carel B Hoyng, Camiel J F Boon
PURPOSE: To assess the short-term outcome of and possible temporary vision loss after half-dose verteporfin photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC). METHODS: In this prospective study, 14 eyes of 13 cCSC patients who underwent half-dose PDT were included. Patients received spectral-domain optical coherence tomography (OCT) imaging and microperimetry before PDT on the day of treatment and 1 week after treatment...
December 16, 2016: Retinal Cases & Brief Reports
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