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foveal thickness

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https://www.readbyqxmd.com/read/28324879/quantitative-analysis-of-uveitis-macular-edema-in-multiple-sclerosis-patients-receiving-deep-posterior-sub-tenon-triamcinolone-acetonide-injection
#1
Svetlana Jovanović, Tatjana Šarenac Vulović, Filip Radotić, Zorica Tončić, Maja Živković, Nenad Petrović
AIM: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators. METHODS: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores...
March 22, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28315319/interferon-alpha2a-and-systemic-corticosteroid-in-monotherapy-in-chronic-uveitis-results-of-the-randomised-controlled-birdferon-study
#2
Christine Fardeau, Anne Simon, Benoît Rodde, Fabiana Viscogliosi, Pierre Labalette, Vincent Looten, Sophie Tézenas du Montcel, Phuc LeHoang
PURPOSE: Macular edema is the leading cause of vision loss in bilateral chronic non-infectious posterior uveitis, and is used to being treated using corticosteroids, immunosuppressive agents and biotherapies. The aim of this trial was to assess and compare the efficacy and safety of corticosteroids and IFN-α in adults with such conditions. STUDY DESIGN: Randomized controlled trial SUBJECTS: Adult patients with bilateral posterior autoimmune non-infectious and non-tumoral uveitis complicated by macular edema in at least one eye, were recruited...
March 14, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303988/cystoid-macular-oedema-after-phacoemulsification-with-and-without-type-2-diabetes-mellitus-a-hospital-based-clinical-prospective-trial-in-karachi
#3
Abdul Haleem, Adil Saleem, Saleh Memon, Nasir Memon, Muhammad Faisal Fahim
OBJECTIVE: To know the outcomes of cystoid macular oedema after phacoemulsification in patients with and without type 2 diabetes mellitus using optical coherence tomography. METHODS: This non-concurrent, clinical, prospective study was carried out at Al-Ibrahim Eye Hospital, Karachi, from January to August 2015. After phacoemulsification with injectable posterior chamber intraocular lens implantation, eyes of patients were analysed. The patients were divided into diabetic and non-diabetic groups visual acuity, optical coherence tomography and dilated fundus examination were performed preoperatively (baseline) and post-operative 1st week and 6th week...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28299239/variability-of-retinal-thickness-measurements-in-tilted-or-stretched-optical-coherence-tomography-images
#4
Akihito Uji, Nizar Saleh Abdelfattah, David S Boyer, Siva Balasubramanian, Jianqin Lei, SriniVas R Sadda
PURPOSE: To investigate the level of inaccuracy of retinal thickness measurements in tilted and axially stretched optical coherence tomography (OCT) images. METHODS: A consecutive series of 50 eyes of 50 patients with age-related macular degeneration were included in this study, and Cirrus HD-OCT images through the foveal center were used for the analysis. The foveal thickness was measured in three ways: (1) parallel to the orientation of the A-scan (Tx), (2) perpendicular to the retinal pigment epithelium (RPE) surface in the instrument-displayed aspect ratio image (Ty), and (3) thickness measured perpendicular to the RPE surface in a native aspect ratio image (Tz)...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28299006/characteristics-of-macular-edema-in-behcet-disease-after-intravitreal-bevacizumab-injection
#5
Fariba Ghassemi, Sohrab Afshari Mirak, Hormoz Chams, Siamak Sabour, Mehdi Nilli Ahmadabadi, Fereidoun Davatchi, Farhad Shahram
PURPOSE: To investigate the effect of intravitreal bevacizumab (IVB) injection on macular edema (ME) secondary to Behcet's disease. METHODS: This prospective case series included 15 patients with bilateral ME due to Behcet's disease. Intravitreal bevacizumab was injected into the more severely involved eye; the contralateral eye was evaluated as the control. Patients were followed up with comprehensive ocular examination, optical coherence tomography, and fluorescein angiography (FA) for a minimum of 6 months by a single ophthalmologist...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28297029/alterations-of-the-foveal-avascular-zone-measured-by-optical-coherence-tomography-angiography-in-glaucoma-patients-with-central-visual-field-defects
#6
Junki Kwon, Jaewan Choi, Joong Won Shin, Jiyun Lee, Michael S Kook
Purpose: To investigate whether the area and shape of the foveal avascular zone (FAZ) as assessed by optical coherence tomography angiography (OCTA) are altered in glaucomatous eyes with central visual field defects (CVFDs). Methods: A total of 78 patients with open-angle glaucoma with central or peripheral visual field defects (PVFDs) confined to a single hemifield were studied retrospectively. Foveal avascular zone area and circularity were measured using OCTA images from the superficial retinal layer...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28292270/short-term-effects-of-intravitreal-ranibizumab-therapy-on-diabetic-macular-edema
#7
Yoshiro Minami, Taiji Nagaoka, Akihiro Ishibazawa, Akitoshi Yoshida
BACKGROUND: The short-term effects of intravitreal ranibizumab (IVR) on diabetic macular edema (DME) remains unclear. We assessed the short-term effects of IVR on DME. METHODS: Eighteen eyes of 14 patients with DME were enrolled in this prospective interventional case series. After intravitreal ranibizumab was injected into treatment-naïve eyes with DME, we measured the foveal thickness (FT) before and 2 h, 1 day, 1 week, and 1 month later and the best-corrected visual acuity (BCVA) at all times except 2 h and compared the changes to baseline (ΔFT and ΔVA)...
March 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28286756/x-linked-retinoschisis-in-juveniles-follow-up-by-optical-coherence-tomography
#8
Qin-Rui Hu, Lv-Zhen Huang, Xiao-Li Chen, Hui-Ka Xia, Tian-Qi Li, Xiao-Xin Li
Purpose. To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT). Design. Retrospective, observational study. Methods. Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016. Each eye was measured by SD-OCT using the same clinical protocol. A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28284785/the-clinical-importance-of-changes-in-diabetic-retinopathy-severity-score
#9
Michael S Ip, Jiameng Zhang, Jason S Ehrlich
PURPOSE: To investigate the clinical importance of changes in diabetic retinopathy severity score (DRSS) in patients with diabetic macular edema (DME) treated with intravitreal ranibizumab. DESIGN: Post hoc analysis of the phase III RIDE and RISE studies of ranibizumab for treatment of DME. PARTICIPANTS: Four hundred sixty-eight eyes treated with ranibizumab from randomization with gradable DRSS on baseline fundus photographs. METHODS: Visual and anatomic outcomes were examined in eyes grouped according to DRSS change from baseline to month 24...
March 8, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28283896/fluocinolone-acetonide-intravitreal-implant-0-19%C3%A2-mg-iluvien-%C3%A2-a-review-in-diabetic-macular-edema
#10
Yahiya Y Syed
Fluocinolone acetonide intravitreal implant 0.19 mg (ILUVIEN(®)) is a nonbiodegradable, injectable, corticosteroid implant that is approved in several countries, including the USA, for the treatment of diabetic macular edema (DME). ILUVIEN(®) releases fluocinolone acetonide at an initial rate of 0.25 µg/day (average rate 0.2 µg/day) and lasts 36 months. In the two pooled pivotal FAME trials in patients with DME previously treated with macular laser photocoagulation, fluocinolone acetonide intravitreal implant 0...
March 10, 2017: Drugs
https://www.readbyqxmd.com/read/28283280/foveal-hypoplasia-in-patients-with-stickler-syndrome
#11
Itsuka Matsushita, Tatsuo Nagata, Takaaki Hayashi, Kenichi Kimoto, Toshiaki Kubota, Masahito Ohji, Shunji Kusaka, Hiroyuki Kondo
PURPOSE: To determine the microstructure of the fovea in patients with Stickler syndrome using imaging by spectral-domain optical coherence tomography (SD OCT) and swept-source OCT. DESIGN: Retrospective case series study. PARTICIPANTS: A total of 39 eyes of 25 patients with genetically confirmed Stickler syndrome were studied. METHODS: All of the patients had mutations in the COL2A1 gene and were diagnosed with Stickler syndrome...
March 7, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28272284/quantitative-analysis-of-structural-alterations-in-the-choroid-of-patients-with-active-beh%C3%A3-et-uveitis
#12
Sumru Onal, Gunay Uludag, Merih Oray, Emre Mengi, Carl P Herbort, Mehmet Akman, Mustafa M Metin, Aylin Koc Akbay, Ilknur Tugal-Tutkun
PURPOSE: To quantitatively analyze in vivo morphology of subfoveal choroid during an acute attack of Behçet uveitis. METHODS: In this prospective study, 28 patients with Behçet uveitis of ≤4-year duration, and 28 control subjects underwent enhanced depth imaging optical coherence tomography. A novel custom software was used to calculate choroidal stroma-to-choroidal vessel lumen ratio. Subfoveal choroidal thickness was measured at fovea and 750 μm nasal, temporal, superior, and inferior to fovea...
March 7, 2017: Retina
https://www.readbyqxmd.com/read/28272283/dexamethasone-intravitreal-implant-vs-ranibizumab-in-the-treatment-of-macular-edema-secondary-to-brachytherapy-for-choroidal-melanoma
#13
Andrea Russo, Michele Reibaldi, Teresio Avitabile, Maurizio G Uva, Livio Marco Franco, Caterina Gagliano, Vincenza Bonfiglio, Corrado Spatola, Giuseppe Privitera, Antonio Longo
PURPOSE: To evaluate the efficacy of an intravitreal dexamethasone (Dex) implant 0.7 mg compared with intravitreal ranibizumab (Ra) for the treatment of radiation maculopathy with macular edema secondary to plaque brachytherapy in choroidal melanoma. METHODS: Eight patients were treated with intravitreal Ra, and eight patients received the Dex intravitreal implant. Visual acuity and foveal thickness were evaluated using spectral domain optical coherence tomography...
March 7, 2017: Retina
https://www.readbyqxmd.com/read/28265755/the-effect-of-center-point-shift-on-the-measurement-of-macular-thickness-a-spectral-domain-optical-coherence-tomography-study
#14
Kyoung Nam Kim, Il Hwan Shin, Jae Yun Sung, Baek Soo Kwak, Hyung Bin Lim, Young Joon Jo, Jung Yeul Kim
PURPOSE: To evaluate the effect of spectral domain-optical coherence tomography (SD-OCT) measurement center shift on the measurement of macular thickness. METHODS: This was a prospective observational case series. A total of 60 normal eyes of 60 subjects included in the study. SD-OCT macular scanning (macular cube 512 × 128 scan) was performed twice by an experienced examiner. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) were recorded...
March 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28263219/influence-of-vitrectomy-surgery-on-the-integrity-of-outer-retinal-layers-in-diabetic-macular-edema
#15
Akihito Uji, Tomoaki Murakami, Kiyoshi Suzuma, Shin Yoshitake, Shigeta Arichika, Rima Ghashut, Masahiro Fujimoto, Nagahisa Yoshimura
PURPOSE: To investigate the influence of pars plana vitrectomy (PPV) on the integrity of photoreceptor layers in eyes with diabetic macular edema (DME) by using parallelism (a parameter that comprehensively reflects photoreceptor-retinal pigment epithelium [RPE] complex alterations) in spectral-domain optical coherence tomography (SD-OCT) imaging. METHODS: A consecutive series of 64 eyes in 55 patients with diabetic macular edema who underwent pars plana vitrectomy were recruited into the study...
January 27, 2017: Retina
https://www.readbyqxmd.com/read/28255575/microstructural-visual-system-changes-in-aqp4-antibody-seropositive-nmosd
#16
Frederike C Oertel, Joseph Kuchling, Hanna Zimmermann, Claudia Chien, Felix Schmidt, Benjamin Knier, Judith Bellmann-Strobl, Thomas Korn, Michael Scheel, Alexander Klistorner, Klemens Ruprecht, Friedemann Paul, Alexander U Brandt
OBJECTIVE: To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system in patients without clinically overt visual symptoms or visual pathway lesions. METHODS: Of 51 screened patients with NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab-seropositive NMOSD patients with longitudinally extensive transverse myelitis (LETM) but no history of optic neuritis (ON) or other bout (NMOSD-LETM) to 19 AQP4-ab-seropositive NMOSD patients with previous ON (NMOSD-ON) and 26 healthy controls (HCs)...
May 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28255227/five-year-outcomes-of-pars-plana-vitrectomy-for-macular-edema-associated-with-branch-retinal-vein-occlusion
#17
Akihiro Nishida, Hiroshi Kojima, Takanori Kameda, Michiko Mandai, Yasuo Kurimoto
PURPOSE: Long-term outcomes of pars plana vitrectomy (PPV) for macular edema (ME) associated with branch retinal vein occlusion (BRVO) have been previously reported, but the studies did not report the number of additional treatments after surgery. During 5 years of follow-up, we therefore investigated the efficacy and safety of PPV for BRVO and evaluated the incidence of additional treatments. METHODS: We retrospectively reviewed the medical records of 25 eyes of 24 patients who underwent PPV for ME associated with BRVO and were followed up for at least 5 years...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28252875/effect-of-preoperative-topical-diclofenac-on-intraocular-interleukin-12-concentration-and-macular-edema-after-cataract-surgery-in-patients-with-diabetic-retinopathy-a-randomized-controlled-trial
#18
Aleksej Medić, Tomislav Jukić, Anita Matas, Katarina Vukojević, Ada Sapunar, Ljubo Znaor
AIM: To determine if preoperative treatment with a topical non-steroidal anti-inflammatory drug (NSAID) lowers the concentration of intraocular interleukin (IL)-12 and the incidence of postoperative macular edema in patients with non-proliferative diabetic retinopathy undergoing cataract surgery. METHODS: A total of 55 patients were randomized to diclofenac (n=27) or placebo (n=28). Patients receiving diclofenac started preoperative treatment with 0.1% topical diclofenac four times a day 7 days before cataract surgery and the therapy was discontinued 30 days after surgery...
February 28, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28251811/head-to-head-comparison-of-ranibizumab-prn-versus-single-dose-dexamethasone-for-branch-retinal-vein-occlusion-comrade-b
#19
Lars-Olof Hattenbach, Nicolas Feltgen, Thomas Bertelmann, Steffen Schmitz-Valckenberg, Hüsnü Berk, Nicole Eter, Gabriele E Lang, Matus Rehak, Simon R Taylor, Armin Wolf, Claudia Weiss, Eva-Maria Paulus, Amelie Pielen, Hans Hoerauf
PURPOSE: To compare the efficacy and safety of ranibizumab 0.5 mg versus dexamethasone 0.7 mg according to their European labels in macular oedema secondary to branch retinal vein occlusion (BRVO) in a 6-month, phase IIIb, randomized trial. METHODS: Patients received either monthly ranibizumab for 3 months followed by Pro re nata (PRN) treatment (n = 126) or a sustained-release dexamethasone implant followed by PRN sham injections (n = 118). Main outcomes were mean average change in best-corrected visual acuity (BCVA) from baseline to month 1 through month 6, mean changes in BCVA and foveal centre point thickness (FCPT), and adverse events (AEs)...
March 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28251089/long-term-follow-up-of-vitrectomy-in-patients-with-pathologic-myopic-foveoschisis
#20
Ting Zhang, Ying Zhu, Chun-Hui Jiang, Ge-Zhi Xu
AIM: To report the long-term surgical outcomes of pathologic myopic foveoschisis (MF) following vitrectomy. METHODS: We performed a retrospective case series analysis of 50 consecutive patients diagnosed with MF who experienced vision loss due to progression of foveoschisis. The 50 patients (67 eyes) were treated in our hospital with vitrectomy with internal limiting membrane (ILM) peeling from December 2004 to September 2010. Best corrected visual acuity (BCVA), refractive error, optical coherence tomography (OCT), and routine examination results were analysed...
2017: International Journal of Ophthalmology
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