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https://www.readbyqxmd.com/read/28408970/differential-regulation-of-cardiac-function-and-intracardiac-cytokines-by-rapamycin-in-healthy-and-diabetic-rats
#1
Christian Luck, Vincent G DeMarco, Abuzar Mahmood, Madhavi P Gavini, Lakshmi Pulakat
Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immunosuppressant, we examined whether Rapamycin (750 μg/kg/day) modulates intracardiac cytokines, which affect the cardiac immune response, and cardiac function in male lean (ZL) and diabetic obese Zucker (ZO) rats...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28405282/ecological-application-of-biotic-resistance-to-control-the-invasion-of-an-invasive-plant-ageratina-altissima
#2
Chaeho Byun, Eun Ju Lee
Biotic resistance is the ability of species in a community to limit the invasion of other species. However, biotic resistance is not widely used to control invasive plants. Experimental, functional, and modeling approaches were combined to investigate the processes of invasion by Ageratina altissima (white snakeroot), a model invasive species in South Korea. We hypothesized that (1) functional group identity would be a good predictor of biotic resistance to A. altissima, whereas a species identity effect would be redundant within a functional group, and (2) mixtures of species would be more resistant to invasion than monocultures...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28357080/association-of-renal-function-with-clinical-parameters-and-conditions-in-a-longitudinal-population-based-epidemiological-study
#3
Takuya Sumi, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Kimihiko Kato, Kota Matsui, Ichiro Takeuchi, Toyoaki Murohara, Yoshiji Yamada
The aim of the present study was to examine the association of renal function with clinical parameters and conditions in the general population. Study subjects comprised 6,027 community-dwelling individuals who were recruited to the Inabe Health and Longevity Study: A longitudinal genetic epidemiological study of atherosclerotic, cardiovascular and metabolic diseases. The cutoff value, which was used to divide the subjects into those with normal and those with low estimated glomerular filtration rate (eGFR), was 60 ml/min/1...
February 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28337213/root-branching-is-a-leading-root-trait-of-the-plant-economics-spectrum-in-temperate-trees
#4
Rebecca Liese, Katrin Alings, Ina C Meier
Global vegetation models use conceived relationships between functional traits to simulate ecosystem responses to environmental change. In this context, the concept of the leaf economics spectrum (LES) suggests coordinated leaf trait variation, and separates species which invest resources into short-lived leaves with a high expected energy return rate from species with longer-lived leaves and slower energy return. While it has been assumed that being fast (acquisitive) or slow (conservative) is a general feature for all organ systems, the translation of the LES into a root economics spectrum (RES) for tree species has been hitherto inconclusive...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28316346/invasion-trajectory-of-pacific-oysters-in-the-northern-wadden-sea
#5
Karsten Reise, Christian Buschbaum, Heike Büttger, Johannes Rick, K Mathias Wegner
Invasion trajectories of introduced alien species usually begin with a long establishment phase of low abundance, often followed by exponential expansion and subsequent adjustment phases. We review the first 26 years of feral Pacific oysters Crassostrea gigas around the island of Sylt in the Wadden Sea (North Sea, NE Atlantic), and reveal causal conditions for the invasion phases. Sea-based oyster farming with repeated introductions made establishment of feral oysters almost inevitable. Beds of mussels Mytilus edulis on mud flats offered firm substrate for attachment and ideal growth conditions around low tide level...
2017: Marine Biology
https://www.readbyqxmd.com/read/28299152/ebola-viral-disease-in-west-africa-a-threat-to-global-health-economy-and-political-stability
#6
Semeeh Akinwale Omoleke, Ibrahim Mohammed, Yauba Saidu
The West African sub-continent is currently experiencing its first, and ironically, the largest and longest Ebola viral diseases (EVD) outbreak ever documented in modern medical history. The current outbreak is significant in several ways, including longevity, magnitude of morbidity and mortality, occurrence outside the traditional niches, rapid spread and potential of becoming a global health tragedy. The authors provided explicit insights into the current and historical background, drivers of the epidemic, societal impacts, status of vaccines and drugs development and proffered recommendations to halt and prevent future occurrences...
August 17, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28254611/practical-economical-and-eco-friendly-starch-supported-palladium-catalyst-for-suzuki-coupling-reactions
#7
Talat Baran
In catalytic systems, the support materials need to be both eco friendly and low cost as well as having high thermal and chemical stability. In this paper, a novel starch supported palladium catalyst, which had these outstanding properties, was designed and its catalytic activity was evaluated in a Suzuki coupling reaction under microwave heating with solvent-free and mild reaction conditions. The starch supported catalyst gave remarkable reaction yields after only 5min as a result of the coupling reaction of the phenyl boronic acid with 23 different substrates, which are bearing aril bromide, iodide, and chloride...
February 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28216454/protective-effects-of-short-term-dietary-restriction-in-surgical-stress-and-chemotherapy
#8
REVIEW
Sebastian Brandhorst, Eylul Harputlugil, James R Mitchell, Valter D Longo
Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery...
February 20, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28118644/the-gender-association-of-the-sirt1-rs7895833-polymorphism-with-pediatric-obesity-a-3-year-panel-study
#9
Myoungsook Lee, Serim Choi, Yunkyoung Lee, Hyun-Hee Oh
OBJECTIVES: Sirtuin 1 (SIRT1), a longevity-associated gene, has pleiotropic functions. We investigated whether SIRT1 variation is associated with pediatric obesity. METHODS: During 3 years of follow-up of 219 children (101 boys, 118 girls) aged 8 or 9 years at baseline, obesity parameters such as anthropometrics, plasma lipid and insulin resistance profiles, and nutrient intakes were analyzed with regard to 3 genotypes of SIRT1 rs7895833 (GG, GA, and AA). RESULTS: The prevalence of obesity including overweight had increased from 18...
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28057705/translational-control-of-lipogenic-enzymes-in-the-cell-cycle-of-synchronous-growing-yeast-cells
#10
Heidi M Blank, Ricardo Perez, Chong He, Nairita Maitra, Richard Metz, Joshua Hill, Yuhong Lin, Charles D Johnson, Vytas A Bankaitis, Brian K Kennedy, Rodolfo Aramayo, Michael Polymenis
Translational control during cell division determines when cells start a new cell cycle, how fast they complete it, the number of successive divisions, and how cells coordinate proliferation with available nutrients. The translational efficiencies of mRNAs in cells progressing synchronously through the mitotic cell cycle, while preserving the coupling of cell division with cell growth, remain uninvestigated. We now report comprehensive ribosome profiling of a yeast cell size series from the time of cell birth, to identify mRNAs under periodic translational control...
January 5, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28056856/potential-unfavorable-impacts-of-bdnf-val66met-polymorphisms-on-metabolic-risks-in-average-population-in-a-longevous-area
#11
Jun-Hua Peng, Cheng-Wu Liu, Shang-Ling Pan, Hua-Yu Wu, Qing-Hua Liang, Rui-Jing Gan, Ling Huang, Yi Ding, Zhang-Ya Bian, Hao Huang, Ze-Ping Lv, Xiao-Ling Zhou, Rui-Xing Yin
BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi...
January 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28052287/is-overnight-fasting-before-surgery-too-much-or-not-enough-how-basic-aging-research-can-guide-preoperative-nutritional-recommendations-to-improve-surgical-outcomes-a-mini-review
#12
Alban Longchamp, Eylul Harputlugil, Jean-Marc Corpataux, C Keith Ozaki, James R Mitchell
Dietary restriction (DR) is best known for extending lifespan in experimental model organisms, but also increases resistance to a variety of clinically relevant stressors, including those associated with surgery. Extended periods of DR, lasting months to years, are required for optimal longevity benefits in rodents, but short-term dietary preconditioning (less than 1 week) remarkably protects from acute injury. Here, we discuss recent advances in our understanding of the mechanistic basis of short-term DR and fasting in the context of surgical stress resistance, including upstream amino acid sensing by the GCN2 and mTORC1 pathways, and downstream effector mechanisms including increased insulin-dependent prosurvival signaling and elevated endogenous hydrogen sulfide production...
2017: Gerontology
https://www.readbyqxmd.com/read/28049707/pleiotropic-effects-of-loss-of-the-d%C3%AE-1-subunit-in-drosophila-melanogaster-implications-for-insecticide-resistance
#13
Jason Somers, Hang Ngoc Bao Luong, Judith Mitchell, Philip Batterham, Trent Perry
Nicotinic acetylcholine receptors (nAChRs) are a highly conserved gene family that form pentameric receptors involved in fast excitatory synaptic neurotransmission. The specific roles individual nAChR subunits perform in Drosophila melanogaster and other insects are relatively uncharacterized. Of the 10 D. melanogaster nAChR subunits, only three have described roles in behavioral pathways; Dα3 and Dα4 in sleep, and Dα7 in the escape response. Other subunits have been associated with resistance to several classes of insecticides...
January 2017: Genetics
https://www.readbyqxmd.com/read/28035278/mating-and-longevity-in-ant-males
#14
Sina Metzler, Jürgen Heinze, Alexandra Schrempf
Across multicellular organisms, the costs of reproduction and self-maintenance result in a life history trade-off between fecundity and longevity. Queens of perennial social Hymenoptera are both highly fertile and long-lived, and thus, this fundamental trade-off is lacking. Whether social insect males similarly evade the fecundity/longevity trade-off remains largely unstudied. Wingless males of the ant genus Cardiocondyla stay in their natal colonies throughout their relatively long lives and mate with multiple female sexuals...
December 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27989925/cholesterol-regulates-daf-16-nuclear-localization-and-fasting-induced-longevity-in-c-elegans
#15
Akiko Ihara, Masaharu Uno, Koichi Miyatake, Sakiko Honjoh, Eisuke Nishida
Cholesterol has attracted significant attention as a possible lifespan regulator. It has been reported that serum cholesterol levels have an impact on mortality due to age-related disorders such as cardiovascular disease. Diet is also known to be an important lifespan regulator. Dietary restriction retards the onset of age-related diseases and extends lifespan in various organisms. Although cholesterol and dietary restriction are known to be lifespan regulators, it remains to be established whether cholesterol is involved in dietary restriction-induced longevity...
January 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/27864957/applications-of-the-fast-slow-continuum-and-reproductive-strategy-framework-of-plant-life-histories
#16
REVIEW
Roberto Salguero-Gómez
I. II. III. IV. References SUMMARY: Understanding the forces that shape the great amount of variation in plant longevity, reproductive output and growth rate is fundamental to effective predictions of viability, invasions and evolutionary pressures. Here, I extend the recently introduced 'fast-slow continuum and reproductive strategy' framework to quantify the variation in plant life history strategies world-wide. I use high-resolution demographic information from 625 plant species and show that this framework predicts not only key demographic properties, such as population growth rate and demographic resilience, but also has important connections to the leaf economics spectrum, biogeographical characteristics, evolutionary biology and conservation biology...
November 16, 2016: New Phytologist
https://www.readbyqxmd.com/read/27843312/formulation-characterization-and-tissue-distribution-of-a-novel-ph-sensitive-long-circulating-liposome-based-theranostic-suitable-for-molecular-imaging-and-drug-delivery
#17
Yin Duan, Lihui Wei, Julia Petryk, Terrence D Ruddy
PURPOSE: When designing liposome formulas for treatment and diagnostic purposes, two of the most common challenges are 1) the lack of a specific release mechanism for the encapsulated contents and 2) a short circulation time due to poor resistance to biological fluids. This study aimed to create a liposome formula with prolonged in vivo longevity and pH-sensitivity for cytoplasmic drug delivery. MATERIALS AND METHODS: Liposomal particles were generated using hydrogenated soy (HS) phosphatidylcholine, cholesteryl hemisuccinate (CHEM), polyethylene glycol (PEG) and diethylenetriaminepentaacetic acid-modified phosphatidylethanolamine with film hydration and extrusion methods...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27820656/insulinlike-growth-factor-binding-protein-1-and-ghrelin-predict-health-outcomes-among-older-adults-cardiovascular-health-study-cohort
#18
Robert C Kaplan, Garrett Strizich, Chino Aneke-Nash, Clara Dominguez-Islas, Petra Bužková, Howard Strickler, Thomas Rohan, Michael Pollak, Lewis Kuller, Jorge R Kizer, Anne Cappola, Christopher I Li, Bruce M Psaty, Anne Newman
Context: Multiple diseases may explain the association of the growth hormone/insulinlike growth factor-I (GH/IGF-I) axis with longevity. Objective: To relate circulating GH/IGF-I system protein levels with major health events. Design and Setting: This is a cohort study set in 4 US communities. Participants: Adults (N = 2268) 65 years and older free of diabetes and cardiovascular disease. Measurements: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3...
January 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27806550/an-overview-on-cardiovascular-risks-definitions-by-using-survival-analysis-techniques-tehran-lipid-and-glucose-study-13-year-follow-up-outcomes
#19
Nezhat Shakeri, Farhad Hajsheikholeslami, Amir Abbas Momenan, Fereidoun Azizi
Risk assessment is an important issue for starting medication for patients. Literature reveals that diabetes, hypertension, dyslipidemia and Body Mass Index (BMI) are among major risk factors for longevity. Since the cut-off points proposed in various sources are generally irrespective of age, sex and race, it has been attempted to validate current definitions for Tehran's elderly population by using a prospective cohort study. For this purpose, one thousand seven hundred and ninety eight (1,798) individuals above 60 years old were recruited in the primary phase of the Tehran Lipid and Glucose Study (TLGS) during 1998-2001, and were tested for their systolic and diastolic blood pressure, total cholesterol, LDL cholesterol, high density lipoprotein cholesterol (HDL), triglyceride (TG), fasting blood sugar (FBS), 2-h plasma glucose (2HPG) and some other factors at the time of entry to the study...
August 26, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27765118/-association-between-serum-albumin-and-cognitive-performance-in-elderly-chinese
#20
Z X Yin, J L Wang, Y B Lyu, J S Luo, Y Zeng, X M Shi
Objective: To explore association between serum albumin level and cognitive performance in elderly Chinese. Methods: All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical indepth CLHLS study, information about subjects' demographic characteristics, lifestyle, prevalence of diseases and health status was collected through household-interview. The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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