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https://www.readbyqxmd.com/read/28441443/the-effect-of-parental-factors-in-children-with-large-cup-to-disc-ratios
#1
Hae-Young Lopilly Park, Min Ji Ha, Sun Young Shin
BACKGROUND: To investigate large cup-to-disc ratios (CDR) in children and to determine the relationship between parental CDR and clinical characteristics associated with glaucoma. METHODS: Two hundred thirty six children aged 6 to 12 years with CDR ≥ 0.6 were enrolled in this study. Subjects were classified into two groups based on parental CDR: disc suspect children with disc suspect (CDR ≥0.6) parents and disc suspect children without disc suspect parents...
2017: PloS One
https://www.readbyqxmd.com/read/28431586/expression-of-calcitonin-gene-related-peptide-in-the-infrapatellar-fat-pad-in-knee-osteoarthritis-patients
#2
Jun Aikawa, Kentaro Uchida, Shotaro Takano, Gen Inoue, Atsushi Minatani, Masayuki Miyagi, Dai Iwase, Hiroyuki Sekiguchi, Manabu Mukai, Masashi Takaso
BACKGROUND: The infrapatellar fat pad (IPFP) has been implicated as a possible source of osteoarthritis (OA) development and knee pain due to the production of inflammatory mediators and the existence of nerve fibers within this structure. Calcitonin gene-related peptide (CGRP) is a vasodilatory neuropeptide that is localized to joint tissues and has recently been implicated in the development of knee OA and OA pain. To date, however, the expression levels of CGRP in the IPFP of human knee OA patients have not been examined...
April 21, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28429415/rod-shaped-neural-units-for-aligned-3d-neural-network-connection
#3
Midori Kato-Negishi, Hiroaki Onoe, Akane Ito, Shoji Takeuchi
This paper proposes neural tissue units with aligned nerve fibers (called rod-shaped neural units) that connect neural networks with aligned neurons. To make the proposed units, 3D fiber-shaped neural tissues covered with a calcium alginate hydrogel layer are prepared with a microfluidic system and are cut in an accurate and reproducible manner. These units have aligned nerve fibers inside the hydrogel layer and connectable points on both ends. By connecting the units with a poly(dimethylsiloxane) guide, 3D neural tissues can be constructed and maintained for more than two weeks of culture...
April 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28427062/emerging-issues-for-optical-coherence-tomography
#4
Luisa Pierro, Alessandro Rabiolo
Almost 25 years after its introduction, optical coherence tomography (OCT) is still a crucial test in the evaluation of patients affected by diabetic retinopathy. In this chapter, the authors provide an extensive overview of the posterior segment pathological changes induced by diabetes, characterized using OCT. OCT plays a key role in diabetic macular edema (DME) as it assesses related retinal changes both in a qualitative (i.e., DME pattern, presence and aspects of cysts, fluid localization, integrity, and reflectivity of retinal layers) and quantitative (i...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28424747/association-between-optic-nerve-head-microcirculation-and-macular-ganglion-cell-complex-thickness-in-eyes-with-untreated-normal-tension-glaucoma-and-a-hemifield-defect
#5
Ayako Anraku, Kyoko Ishida, Nobuko Enomoto, Seiji Takagi, Hiroyuki Ito, Asuka Takeyama, Fumihiko Yagi, Goji Tomita
Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28412542/reduction-of-retinal-nerve-fiber-layer-thickness-in-vigabatrin-exposed-patients-a-meta-analysis
#6
Yingqian Peng, Yinan Zhao, Wenyu Hu, Yongmei Hu, Yan He, Yedi Zhou
OBJECTIVE: Vigabatrin (VGB) is currently served as an effective adjunctive therapy for patients with partial epilepsy worldwide. In this study, meta-analysis was conducted to comprehensively evaluate the changes in peripapillary retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography (OCT) in epilepsy patients who were treated by VGB. MATERIAL AND METHODS: Publications on PubMed, Wiley Online Library and the Elsevier Science databases were searched by September 2016...
April 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28412067/trend-based-analysis-of-ganglion-cell-inner-plexiform-layer-thickness-changes-on-optical-coherence-tomography-in-glaucoma-progression
#7
Won June Lee, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
PURPOSE: To evaluate the rate of thinning in ganglion cell-inner plexiform layer (GCIPL) thickness by optical coherence tomography (OCT) in glaucomatous eyes and to use a trend-based approach to determine its diagnostic ability for detecting glaucoma progression. DESIGN: Prospective, observational study. PARTICIPANTS: Sixty-five patients with primary open-angle glaucoma with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness...
April 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28410253/factors-associated-with-visual-field-progression-in-cirrus-optical-coherence-tomography-guided-progression-analysis-a-topographic-approach
#8
Joong Won Shin, Kyung Rim Sung, Jiyun Lee, Junki Kwon
PURPOSE: To identify factors associated with visual field (VF) progression in optical coherence tomography (OCT)-guided progression analysis (GPA) using a topographic approach. METHODS: Topographic components of OCT-GPA maps (Cirrus HD-OCT; Carl Zeiss Meditec) were classified according to location (temporal, superotemporal, superonasal, nasal, inferornasal, and inferotemporal), size (small, medium, and large), shape (wedge and irregular types), and pattern of retinal nerve fiber layer (RNFL) progression (widening, deepening, and new development)...
April 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28408781/inflammatory-bowel-disease-affects-density-of-nitrergic-nerve-fibers-in-the-mucosal-layer-of-the-canine-gastrointestinal-tract
#9
Andrzej Rychlik, Slawomir Gonkowski, Marcin Nowicki, Jaroslaw Calka
The objective of this study was to determine the effect of inflammatory bowel disease (IBD) on the density of nitrergic nerve fibers in the mucosal layer of different sections of the gastrointestinal tract of dogs. Twenty-eight German shepherd hybrid dogs of both sexes, weighing from 15 to 25 kg and aged 6 to 10 y, were studied. The dogs were divided into 4 groups with 7 animals in each group: healthy animals, as well as dogs suffering from mild, moderate, and severe IBD. Immunoreactivity to neuronal isoform of nitric oxide synthase, which is a marker of nitrergic neurons, in samples of the mucosal layer in the duodenum, jejunum, and descending colon was studied using the single immunofluorescence method and the number of nerve fibers was evaluated in each observation field...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28408038/temporal-relation-between-macular-ganglion-cell-inner-plexiform-layer-loss-and-peripapillary-retinal-nerve-fiber-layer-loss-in-glaucoma
#10
Young Kook Kim, Ahnul Ha, Kyeong Ik Na, Hae Jin Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the temporal relationship between inferior macular ganglion cell-inner plexiform layer (mGCIPL) loss and corresponding peripapillary retinal nerve fiber layer (pRNFL) defect on the optical coherence tomography (OCT) deviation map in glaucoma. DESIGN: Retrospective, observational study. PARTICIPANTS: A total of 151 patients with early-stage glaucoma (visual field [VF] mean deviation between -1.5 and -5.5 decibels [dB])...
April 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28403437/postretinal-structure-and-function-in-severe-congenital-photoreceptor-blindness-caused-by-mutations-in-the-gucy2d-gene
#11
Geoffrey K Aguirre, Omar H Butt, Ritobrato Datta, Alejandro J Roman, Alexander Sumaroka, Sharon B Schwartz, Artur V Cideciyan, Samuel G Jacobson
Purpose: To examine how severe congenital blindness resulting from mutations of the GUCY2D gene alters brain structure and function, and to relate these findings to the notable preservation of retinal architecture in this form of Leber congenital amaurosis (LCA). Methods: Six GUCY2D-LCA patients (ages 20-46) were studied with optical coherence tomography of the retina and multimodal magnetic resonance imaging (MRI) of the brain. Measurements from this group were compared to those obtained from populations of normally sighted controls and people with congenital blindness of a variety of causes...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28401494/a-comparative-optical-coherence-tomography-study-of-spinocerebellar-ataxia-types-3-and-10
#12
Fernando Spina Tensini, Mario T Sato, Naoye Shiokawa, Tetsuo Ashizawa, Hélio A G Teive
SCA3 presents with a CAG expansion at 14q24.3-q32 while SCA10 shows an ATTCT expansion at 22q13-qter. SCA10 seems to be less aggressive than SCA3. For an in vivo, noninvasive approach of the correlation between central nervous system and clinical evolution, we can use optic coherence tomography (OCT) to measure retinal nerve fiber (RNFL) and ganglion cell layer (GCL) thickness. To describe OCT findings in SCA10, correlate it with expansion size and disease severity and compare with those of SCA3. We analyzed ten individuals with SCA3 and nine with SCA10 recruited from the neurology service of Hospital de Clínicas of Paraná-Brazil...
April 11, 2017: Cerebellum
https://www.readbyqxmd.com/read/28399127/ultrastructural-and-histopathologic-findings-after-pars-plana-vitrectomy-with-a-new-hypersonic-vitrector-system-qualitative-preliminary-assessment
#13
Salvador Pastor-Idoate, Richard Bonshek, Luciane Irion, Isaac Zambrano, Paul Carlin, Aleksandr Mironov, Paul Bishop, David McLeod, Paulo Eduardo Stanga
PURPOSE: Preliminary assessment of a new prototype ultrasound-based hypersonic vitrector (HV) by qualitatively examining the histopathological changes in the retina and vitreous body after pars plana vitrectomy (PPV) and its ability to fragment vitreous collagen. METHODS: Fourteen porcine cadaveric eyes, 20 eyes in live swine and six human cadaveric eyes underwent PPV using the HV or a pneumatic guillotine vitrector (GV). An additional 4 porcine crystalline lenses were touched with either the HV or GV for 1 minute...
2017: PloS One
https://www.readbyqxmd.com/read/28395028/reflectance-spectrum-and-birefringence-of-the-retinal-nerve-fiber-layer-with-hypertensive-damage-of-axonal-cytoskeleton
#14
Xiang-Run Huang, Robert W Knighton, Ye Z Spector, Jianzhong Qiao, Wei Kong, Qi Zhao
Purpose: Glaucoma damages the retinal nerve fiber layer (RNFL). This study used precise multimodal image registration to investigate the changes of the RNFL reflectance spectrum and birefringence in nerve fiber bundles with different degrees of axonal damage. Methods: The reflectance spectrum of individual nerve fiber bundles in normal rats and rats with experimental glaucoma was measured from 400 to 830 nm and their birefringence was measured at 500 nm. Optical measurements of the same bundles were made at different distances from the optic nerve head (ONH)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28394809/structure-function-relationship-between-the-bruch-membrane-opening-based-minimum-rim-width-and-visual-field-defects-in-advanced-glaucoma
#15
Serhat Imamoglu, Nimet Burcu Celik, Mehmet S Sevim, Gokhan Pekel, Nimet Yesim Ercalik, Esra Turkseven Kumral, Handan Bardak
PURPOSE: To investigate the relationship between the Bruch membrane opening-minimum rim width (BMO-MRW) (global and temporal) parameters with spectral-domain optical coherence tomography (SD-OCT) and visual field (VF) sensitivity on the 10-2 test in patients with advanced glaucoma. MATERIALS AND METHODS: This cross-sectional, observational study included a total of 33 eyes of 29 patients. To evaluate VF sensitivity, automated white-on-white perimetry was performed using a Humphrey field analyzer...
April 7, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28394663/evaluation-of-choroidal-and-retinal-thickness-changes-in-parkinson-s-disease-using-spectral-domain-optical-coherence-tomography
#16
Marilita M Moschos, Irini P Chatziralli
PURPOSE: The purpose of this study was to evaluate retinal and choroidal thickness in patients with Parkinson's disease (PD) using spectral domain-optical coherence tomography (SD-OCT). MATERIAL AND METHODS: Participants in our study were 31 PD patients and 25 age-matched healthy controls. All participants underwent best-corrected visual acuity (BCVA) measurement, slit-lamp biomicroscopy, dilated fundoscopy, and SD-OCT. Macular and retinal nerve fiber layer (RNFL) thickness and choroidal thickness in all quadrants were recorded...
April 10, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28392307/electrically-responsive-core-shell-hybrid-microfibers-for-controlled-drug-release-and-cell-culture
#17
Chuntao Chen, Xiao Chen, Heng Zhang, Qi Zhang, Li Wang, Chenxi Li, Beibei Dai, Jiazhi Yang, Jian Liu, Dongping Sun
It is an active research field to develop fiber-shaped smart materials for biomedical applications. Here we report the development of the multifunctional core-shell hybrid microfibers with excellent mechanical and electrical performance as a new smart biomaterial. The microfibers were synthesized using a combination of co-axial spinning with a microfluidic device and subsequent dip-coating, containing a hydrogel core of bacterial cellulose (BC) and a conductive polymer shell layer of poly(3,4-ethylenedioxythiophene) (PEDOT)...
April 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28391270/single-retinal-layer-evaluation-in-patients-with-type-1-diabetes-with-no-or-early-signs-of-diabetic-retinopathy-the-first-hint-of-neurovascular-crosstalk-damage-between-neurons-and-capillaries
#18
Fabio Scarinci, Fabiana Picconi, Gianni Virgili, Paola Giorno, Antonio Di Renzo, Monica Varano, Simona Frontoni, Mariacristina Parravano
PURPOSE: To analyze the retinal-choroidal changes in type 1 diabetes mellitus (DM1) patients with no or early signs of diabetic retinopathy (DR). METHODS: Seventy-six eyes of 38 DM1 patients and 26 control eyes were included. Nine individual retinal layer thickness measurements were obtained using the spectral domain-optical coherence tomography automated segmentation algorithm. RESULTS: The retinal nerve fiber layer was slightly thinner in all explored quadrants, even if the reduction was not significant in DM1 eyes versus control eyes...
April 8, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28387764/crowded-optic-nerve-head-evaluation-with-optical-coherence-tomography-in-anterior-ischemic-optic-neuropathy
#19
S Moghimi, M Afzali, M Akbari, K B Ebrahimi, A Khodabande, A R Yazdani-Abyaneh, S N H Ghafouri, P Coh, S Okhravi, M A Fard
PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups...
April 7, 2017: Eye
https://www.readbyqxmd.com/read/28385127/retinal-nerve-fiber-layer-thickness-and-neuropsychiatric-manifestations-in-systemic-lupus-erythematosus
#20
S Shulman, R Shorer, J Wollman, G Dotan, D Paran
Background Cognitive impairment is frequent in systemic lupus erythematosus. Atrophy of the corpus callosum and hippocampus have been reported in patients with systemic lupus erythematosus, and diffusion tensor imaging studies have shown impaired white matter integrity, suggesting that white matter damage in systemic lupus erythematosus may underlie the cognitive impairment as well as other neuropsychiatric systemic lupus erythematosus manifestations. Retinal nerve fiber layer thickness, as assessed by optical coherence tomography, has been suggested as a biomarker for white matter damage in neurologic disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease...
January 1, 2017: Lupus
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