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https://www.readbyqxmd.com/read/29777305/the-distribution-of-retinal-nerve-fiber-layer-thickness-and-associations-with-age-refraction-and-axial-length-the-gutenberg-health-study
#1
Esther M Hoffmann, Irene Schmidtmann, Angeliki Siouli, Alexander K Schuster, Manfred E Beutel, Norbert Pfeiffer, Julia Lamparter
PURPOSE: To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting. METHODS: In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany)...
May 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29773842/systemic-vascular-risk-factors-for-multiple-retinal-nerve-fiber-layer-defects
#2
Kyoung In Jung, Seon Joo Kim, Chan Kee Park
Multiple retinal nerve fiber layer (RNFL) defects develop uncommonly, even though glaucomatous RNFL loss is typically observed as one RNFL defect in each quadrant. We investigated the risk factors associated with multiple RNFL defects to increase our understanding of the nature and pathogenesis of various RNFL defect patterns. Data from subjects with multiple RNFL defects (28 patients) and glaucoma patients without multiple RNFL defects (194 patients) were analyzed. The term "multiple RNFL defects" refers to three or more isolated defects separated by a comparatively normal area...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772046/bilateral-myelinated-retinal-nerve-fibers-associated-with-bilateral-vitreous-cysts-and-solitary-vasoproliferative-tumor-a-new-syndrome
#3
Nora W Muakkassa, Eric J Schwaber, Nora Laver, Jay S Duker
The authors report a case of a 57-year-old male with high myopia, extensive bilateral myelination of the retinal nerve fiber layer, bilateral vitreous cysts, and a solitary vasoproliferative tumor in the right eye. He underwent pars plana vitrectomy and multiple transpupillary thermotherapy treatments for recurrent vitreous hemorrhages and subretinal exudation from the vasoproliferative tumor. To the authors' knowledge, this is the first description of this constellation of findings and suggests this represents a new syndrome...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29771751/utility-of-optical-coherence-tomography-in-the-evaluation-of-sellar-and-parasellar-mass-lesions
#4
Omar Al-Louzi, Sashank Prasad, Robert M Mallery
PURPOSE OF REVIEW: Anterior visual pathway compression is a common feature of sellar region masses. We review the visual pathway neuroanatomy pertaining to sellar and parasellar lesions and describe recent advances in optical coherence tomography (OCT) imaging that have provided a novel quantitative perspective in the evaluation and management of such patients. RECENT FINDINGS: Ultrastructural measurements of optic nerve integrity using OCT, namely peripapillary retinal nerve fiber layer (pRNFL) and the ganglion cell and inner plexiform layer (GCIPL) thicknesses, have been shown to correlate with visual acuity and visual field deficits on perimetry in patients with compressive sellar region masses...
May 15, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29767815/the-effect-of-glatiramer-acetate-on-retinal-nerve-fiber-layer-thickness-in-patients-with-relapsing-remitting-multiple-sclerosis-a-longitudinal-optical-coherence-tomography-study
#5
Robert Zivadinov, Eleonora Tavazzi, Jesper Hagemeier, Ellen Carl, David Hojnacki, Channa Kolb, Bianca Weinstock-Guttman
BACKGROUND: Optical coherence tomography (OCT) is a technique that allows for the assessment of retinal nerve fiber layer thickness (RNFLT) and total macular volume (TMV), which reflect neuroaxonal integrity within the retina. As such it has been used in multiple sclerosis (MS) to study neurodegeneration. Glatiramer acetate (GA) is a widely used treatment for MS, which is suggested to have a possible neuroprotective role. OBJECTIVE: The aim of this study was to assess RFNLT and TMV changes in relapsing-remitting MS (RRMS) patients who started treatment with GA and were followed for a 24-month period...
May 16, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29765199/the-development-of-a-reference-database-with-the-topcon-3d-oct-1-maestro
#6
Michael Chaglasian, Murray Fingeret, Pinakin Gunvant Davey, Wei-Chieh Huang, Danny Leung, Edmund Ng, Charles A Reisman
Importance: The paper presents the range for measurements taken with a new spectral domain optical coherence tomography (OCT) device to establish a reference database for discrimination purposes. Objective: To report the range of thickness values for the new Topcon Maestro 3D OCT device with 2 scan size settings: the 12×9 mm wide field and 6×6 mm scans. Design: Prospective, multicenter cohort study conducted at 7 clinical sites across the USA...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29765196/optical-coherence-tomography-retinal-nerve-fiber-layer-analysis-in-eyes-with-long-axial-lengths
#7
Sagar B Patel, Nisha Reddy, Xihui Lin, Jess T Whitson
Purpose: To evaluate the relationship between axial length (AL) and retinal nerve fiber layer (RNFL) profile and to characterize differences in optical coherence tomography RNFL of myopic glaucomatous eyes compared to nonglaucomatous eyes. Methods: Retrospective chart review of 170 eyes of 89 subjects with optical biometry and optical coherence tomography RNFL assessment was conducted. Results: Temporal RNFL thickness showed no association with AL in either glaucomatous or nonglaucomatous eyes...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29762268/influence-of-removing-the-large-retinal-vessels-related-effect-on-peripapillary-vessel-density-progression-analysis-in-glaucoma
#8
Gábor Holló
PURPOSE: To investigate the usefulness of removing the large vessel-related information from peripapillary optical coherence tomography (OCT) angiography progression analysis. Peripapillary vessel density (VD) image series which had shown no progression with an earlier software version that did not separate capillary and large vessel-related effects were reevaluated for selective peripapillary capillary VD progression. METHODS: Prospective retinal nerve fiber layer thickness (RNFLT) and peripapillary VD measurements were made using the Angiovue/RTvue-XR OCT on one eye of 9 normal, 20 under treatment ocular hypertensive (OHT) and 24 under treatment open-angle glaucoma patients at 6-month intervals for 2 years (5 visits)...
May 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29760571/multiple-extrafoveal-macular-holes-following-internal-limiting-membrane-peeling
#9
Nazimul Hussain, Sandip Mitra
Objective: Internal limiting membrane (ILM) peeling has been the standard of treatment for macular holes. Besides, causing retinal nerve fiber layer surface abnormality, postoperative extrafoveal multiple retinal holes is a rare phenomenon following ILM peeling. We report an unusual complication of eight extrafoveal macular holes occurring following ILM peeling. Case presentation: A 60-year-old male presented with complaints of decreased and distorted vision in the right eye...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29757807/thicknesses-of-central-macular-retinal-nerve-fiber-and-ganglion-cell-inner-plexiform-layers-in-patients-with-hypertension
#10
Soo Hyun Lee, Woo Hyuk Lee, Hyung Bin Lim, Young Joon Jo, Jung Yeul Kim
PURPOSE: To compare retinal thickness between patients with chronic hypertension without retinopathy, hypertensive retinopathy, Keith-Wagener-Barker Grade IV status, and normal controls using spectral domain optical coherence tomography. METHODS: In this retrospective study, we analyzed patients who visited our retinal clinic from January 2013 to February 2016. Of those included, 58 eyes of 58 patients were in the healthy control group (Group A), 37 eyes of 37 patients were in the chronic hypertension without retinopathy group (disease duration of at least 10 years; Group B), and 31 eyes of 31 patients with relieved hypertensive retinopathy (Grade IV hypertensive retinopathy a year or more ago but no longer had hypertensive retinopathy at the time of the study; Group C)...
May 11, 2018: Retina
https://www.readbyqxmd.com/read/29754292/investigation-of-retinal-nerve-fiber-layer-thickness-and-ganglion-cell-layer-inner-plexiform-layer-thickness-in-patients-with-optic-pathway-gliomas
#11
Mustafa Hepokur, Ahmet Murat Sarici
PURPOSE: This study aimed to compare the optical coherence tomography (OCT) findings of optic pathway glioma (OPG) patients (sporadic or secondary to neurofibromatosis type 1, NF1) with NF1 without OPG patients and healthy controls. METHODS: This was a prospective, case-control study in which 27 patients (13 with OPGs and 14 with NF1 without OPGs) and 13 control subjects were included. The retinal nerve fiber layer (RNFL) thickness, macular thickness, and ganglion cell layer-inner plexiform layer (GCL-IPL) thickness findings measured using OCT and the results were compared between the groups...
May 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29753728/retinal-adaptation-to-dim-light-vision-in-spectacled-caimans-caiman-crocodilus-fuscus-analysis-of-retinal-ultrastructure
#12
Anett Karl, Silke Agte, Astrid Zayas-Santiago, Felix N Makarov, Yomarie Rivera, Jan Benedikt, Mike Francke, Andreas Reichenbach, Serguei N Skatchkov, Andreas Bringmann
It has been shown that mammalian retinal glial (Müller) cells act as living optical fibers that guide the light through the retinal tissue to the photoreceptor cells (Agte et al., 2011; Franze et al., 2007). However, for nonmammalian species it is unclear whether Müller cells also improve the transretinal light transmission. Furthermore, for nonmammalian species there is a lack of ultrastructural data of the retinal cells, which, in general, delivers fundamental information of the retinal function, i.e. the vision of the species...
May 10, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29752047/preoperative-spectral-domain-optical-coherence-tomography-in-patients-having-cataract-surgery
#13
Youssef Abdelmassih, Sylvain El-Khoury, Sophie Georges, Damien Guindolet, Eric Gabison, Isabelle Cochereau
PURPOSE: To evaluate the role and cost-effectiveness of preoperative spectral-domain optical coherence tomography (SD-OCT) in patients having cataract surgery. SETTING: Fondation Opthalmologique Adolphe de Rothschild, Paris, France. DESIGN: Retrospective case series. METHODS: All patients who had cataract surgery had macular and retinal nerve fiber layer SD-OCT preoperatively. A complete ophthalmologic examination was performed, including corrected near (CNVA) and corrected distance visual acuities, intraocular pressure (IOP), and a fundus examination...
May 8, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29750948/altered-macular-microvasculature-in-neuromyelitis-optica-spectrum-disorders
#14
William Robert Kwapong, Chenlei Peng, Zhiyong He, Xiran Zhuang, Meixiao Shen, Fan Lu
PURPOSE: To evaluate macular microvascular changes in neuromyelitis optica spectrum disorders (NMOSD) by using optical coherence tomography angiography (OCT-A) and investigate their correlations with neuroaxonal structural damage evaluated with Spectral domain OCT (SD-OCT). DESIGN: Cross-sectional study. METHODS: Twenty eyes of 20 patients with NMOSD and 21 eyes from 21 healthy controls were enrolled. OCT-A was used to obtain microvascular network images of the whole, superficial, and deep retinal capillary plexuses (WRCP, SRCP, and DRCP) in a 3-mm diameter area around the macula...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750734/evolution-of-visual-outcomes-in-clinical-trials-for-multiple-sclerosis-disease-modifying-therapies
#15
Rachel C Nolan, Omar Akhand, John-Ross Rizzo, Steven L Galetta, Laura J Balcer
: BACKGROUND:: The visual pathways are increasingly recognized as an ideal model to study neurodegeneration in multiple sclerosis (MS). Low-contrast letter acuity (LCLA) and optical coherence tomography (OCT) are validated measures of function and structure in MS. In fact, LCLA was the topic of a recent review by the Multiple Sclerosis Outcome Assessments Consortium (MSOAC) to qualify this visual measure as a primary or secondary clinical trial endpoint with the Food and Drug Administration (FDA) and other regulatory agencies...
June 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29750715/visual-field-tests-for-glaucoma-patients-with-initial-macular-damage-comparison-between-frequency-doubling-technology-and-standard-automated-perimetry-using-24-2-or-10-2-visual-fields
#16
Hae-Young Lopilly Park, Jiyoung Lee, Chan Kee Park
PURPOSE: To compare standard automated perimetry (SAP) and frequency-doubling technology (FDT) perimetry for detecting macular damage in glaucoma. METHODS: One-hundred-twelve glaucomatous eyes with localized retinal nerve fiber layer (RNFL) defects on red-free photographs and corresponding macular ganglion cell/inner plexiform layer (mGC/IPL) thinning on the deviation map of macular optical coherence tomography (OCT), and thirty-five healthy eyes were enrolled in the study...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29749568/structural-changes-of-macula-and-optic-disk-of-the-fellow-eye-in-patients-with-nonarteritic-anterior-ischemic-optic-neuropathy
#17
R Duman, G F Yavas, I Veliyev, M Dogan, R Duman
PURPOSE: The aim was to assess the ganglion cell complex (GCC) thickness, retinal nerve fiber layer (RNFL) thickness and optic disk features in the affected eyes (AE) and unaffected fellow eyes (FE) of subjects with unilateral nonarteritic anterior ischemic optic neuropathy (NAION) and to compare with healthy control eyes (CE) using spectral domain-optical coherence tomography (SD-OCT). METHODS: This study included 28 patients and age, sex and refraction-matched 28 control subjects...
May 10, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29744762/functional-and-morphological-assessment-of-ocular-structures-and-follow-up-of-patients-with-early-stage-parkinson-s-disease
#18
Samir Hasanov, Elif Demirkilinc Biler, Ahmet Acarer, Cezmi Akkın, Zafer Colakoglu, Onder Uretmen
PURPOSE: To evaluate and follow-up of functional and morphological changes of the optic nerve and ocular structures prospectively in patients with early-stage Parkinson's disease. MATERIALS AND METHODS: Nineteen patients with a diagnosis of early-stage Parkinson's disease and 19 age-matched healthy controls were included in the study. All participants were examined minimum three times at the intervals of at least 6 month following initial examination. Pattern visually evoked potentials (VEP), contrast sensitivity assessments at photopic conditions, color vision tests with Ishihara cards and full-field visual field tests were performed in addition to measurement of retinal nerve fiber layer (RNFL) thickness of four quadrants (top, bottom, nasal, temporal), central and mean macular thickness and macular volumes...
May 9, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29736326/evaluation-of-a-qualitative-approach-for-detecting-glaucomatous-progression-using-wide-field-optical-coherence-tomography-scans
#19
Zhichao Wu, Denis S D Weng, Rashmi Rajshekhar, Abinaya Thenappan, Robert Ritch, Donald C Hood
Purpose: To determine the effectiveness of detecting glaucomatous progression by a qualitative evaluation of wide-field (12 × 9 mm) scans on optical coherence tomography imaging. This method was compared to a conventional quantitative analysis of the global circumpapillary retinal nerve fiber layer (cpRNFL) thickness. Methods: A total of 409 eyes with a clinical diagnosis of glaucoma or suspected glaucoma for which two wide-field scans were obtained at least 1 year apart ( n = 125) and within one session ( n = 284) were included to determine the sensitivity of detecting progression at 95% specificity...
May 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29734219/correlation-between-inner-retinal-layer-thickness-and-cognitive-function-in-hiv-new-insights-from-an-exploratory-study
#20
Alessandro Invernizzi, Alessandra Acquistapace, Sara Bochicchio, Chiara Resnati, Stefano Rusconi, Marta Ferrari, Valentina Leta, Simone Pomati, Alexander Klistorner, Peter Mccluskey, Giovanni Staurenghi, Agostino Riva
OBJECTIVE: to compare retinal layer thickness in human immunodeficiency virus (HIV) infected subjects with (CI-HIV) and without (NCI-HIV) cognitive impairment, with a control population and to correlate it with the cognitive status of the patient and other clinical parameters. DESIGN: single center cross-sectional study METHODS:: Subjects with controlled HIV infection aged between 40 and 70 years and sex and age matched controls were enrolled. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL) thickness were assessed using optical coherence tomography...
May 3, 2018: AIDS
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