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https://www.readbyqxmd.com/read/29163338/radial-peripapillary-capillary-network-in-patients-with-retinitis-pigmentosa-an-optical-coherence-tomography-angiography-study
#1
Rodolfo Mastropasqua, Enrico Borrelli, Luca Agnifili, Lisa Toto, Luca Di Antonio, Alfonso Senatore, Michele Palmieri, Alessandro D'Uffizi, Paolo Carpineto
Purpose: To investigate radial peripapillary capillary (RPC) network in patients affected by retinitis pigmentosa (RP). Methods: Eleven patients (22 eyes) with previous diagnosis of RP and 16 age-matched healthy subjects (16 eyes) were enrolled. The diagnosis of RP was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography and visual field (VF)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29157365/the-future-of-imaging-in-detecting-glaucoma-progression
#2
Fabio Lavinsky, Gadi Wollstein, Jenna Tauber, Joel S Schuman
Ocular imaging has been heavily incorporated into glaucoma management and provides important information that aids in the detection of disease progression. Longitudinal studies have shown that the circumpapillary retinal nerve fiber layer is an important parameter for glaucoma progression detection, whereas other studies have demonstrated that macular parameters, such as the ganglion cell inner plexiform layer and optic nerve head parameters, also are useful for progression detection. The introduction of novel technologies with faster scan speeds, wider scanning fields, higher resolution, and improved tissue penetration has enabled the precise quantification of additional key ocular structures, such as the individual retinal layers, optic nerve head, choroid, and lamina cribrosa...
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29157363/detecting-structural-progression-in-glaucoma-with-optical-coherence-tomography
#3
Andrew J Tatham, Felipe A Medeiros
Optical coherence tomography (OCT) is increasingly used to obtain objective measurements of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression. Although OCT has been adopted widely in clinical practice, uncertainty remains concerning its optimal role. Questions include: What is the best structure to measure? What quantity of change is significant? Are structural changes relevant to the patient? How are longitudinal measurements affected by aging? How can changes resulting from aging be differentiated from true progression? How best should OCT be used alongside visual fields, and how often should OCT be performed? Recent studies have addressed some of these questions...
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29149238/diabetic-neuroglial-changes-in-the-superficial-and-deep-nonperfused-areas-on-optical-coherence-tomography-angiography
#4
Yoko Dodo, Tomoaki Murakami, Kiyoshi Suzuma, Shin Yoshitake, Tatsuya Yoshitake, Kenji Ishihara, Masahiro Fujimoto, Yuko Miwa, Akitaka Tsujikawa
Purpose: To evaluate the relationship between lamellar capillary nonperfusion on optical coherence tomography angiography (OCTA) images and neuroglial changes on structural optical coherence tomography (OCT) images in diabetic retinopathy (DR). Methods: We retrospectively reviewed 101 consecutive eyes of 69 patients with DR. OCTA and OCT images within a 3 × 3-mm square centered on the fovea were acquired simultaneously. The nonperfused areas (NPAs) in the superficial capillary layer (sNPA) (from the nerve fiber layer [NFL] to the inner plexiform layer [IPL]), the deep layer (dNPA) (corresponding mainly to the inner nuclear layer [INL]), or both layers (bNPA) were measured individually along 10 transverse lines...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29148032/secondary-glaucoma-in-uveitis-comparison-of-the-optic-nerve-head-morphology-among-a-nonmydriatic-fundus-camera-hrt-and-sd-oct
#5
Milena Pahlitzsch, Matthias K J Klamann, Saskia Jacob, Carl Erb, Sibylle Winterhalter, Necip Torun, Anna-Karina B Maier, Eckart Bertelmann
PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma. METHODS: A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 ± 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D/3D nonmydriatic retinal camera, Kowa Company), the HRT3 (Heidelberg Engineering), and SD-OCT (Carl Zeiss Meditec) by one examiner on the same day...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29148030/incidence-and-quantitative-analysis-of-dissociated-optic-nerve-fiber-layer-appearance-real-loss-of-retinal-nerve-fiber-layer
#6
Yoon J Kim, Kyoung S Lee, Soo G Joe, June-Gone Kim
PURPOSE: To assess the association between appearance of dissociated optic nerve fiber layer (DONFL) after internal limiting membrane (ILM) peeling and changes in the macular nerve fiber layer (NFL) area by spectral-domain optical coherence tomography (SD-OCT). METHODS: This study included 132 consecutive patients who had successfully undergone vitrectomy with ILM peeling for idiopathic epiretinal membrane or macular holes and had been followed up for ≥6 months...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29144506/soluble-p-selectin-promotes-retinal-ganglion-cell-survival-through-activation-of-nrf2-signaling-after-ischemia-injury
#7
Kishan Kapupara, Yao-Tseng Wen, Rong-Kung Tsai, Shun-Ping Huang
Retinal ischemic injuries play an important role in the pathogenesis of several eye disorders. Inflammation and oxidative stress are key players in ischemic injuries. Following retinal ischemia, vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, such as selectins and cell adhesion molecules. P-selectin stimulates leukocyte recruitment to platelet aggregates and has an important role in vascular homeostasis and inflammatory leukocyte extravasation. Soluble P-selectin can be neuroprotective through competitive binding to the receptors of endogenous P-selectin molecules...
November 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29143216/self-perception-and-determinants-of-color-vision-in-parkinson-s-disease
#8
Alexander U Brandt, Hanna G Zimmermann, Timm Oberwahrenbrock, Justine Isensee, Thomas Müller, Friedemann Paul
Visual dysfunction is common in patients with Parkinson's disease (PD). The objective of this study was to investigate the perceived impact of visual dysfunction and especially color vision loss on PD patients, and to identify retinal and disease factors associated with color vision. Thirty PD patients and thirty-four healthy controls were included. Participants performed the Farnsworth-Munsell Hue-100 test (FMT). Patients answered the National Eye Institute Visual Function Questionnaire (NEI-VFQ), Unified Parkinson's Disease Rating Scale (UPDRS) assessment, and underwent optical coherence tomography with measurement of retinal nerve fiber layer, ganglion cell layer + inner plexiform layer (GCIPL), and outer nuclear and photoreceptor layer...
November 15, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29142087/no-evidence-of-disease-activity-is-associated-with-reduced-rate-of-axonal-retinal-atrophy-in-ms
#9
Marco Pisa, Simone Guerrieri, Giovanni Di Maggio, Stefania Medaglini, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Letizia Leocani
OBJECTIVE: To explore, in a longitudinal study, the usefulness of optical coherence tomography (OCT) in monitoring people with multiple sclerosis (MS) by testing the association between retinal nerve fiber layer (RNFL) thinning and clinical and brain MRI criteria of no evidence of disease activity (NEDA). METHODS: OCT, visual evoked potentials (VEPs), and disability, using the Expanded Disability Status Scale (EDSS), were tested at baseline and after 2 years in 72 patients, 63 with routine yearly brain MRI...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29138314/imaging-and-quantifying-ganglion-cells-and-other-transparent-neurons-in-the-living-human-retina
#10
Zhuolin Liu, Kazuhiro Kurokawa, Furu Zhang, John J Lee, Donald T Miller
Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human retina, GCs remain elusive due to their high optical translucency...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29137322/the-c-jun-n-terminal-kinase-plays-a-key-role-in-ocular-degenerative-changes-in-a-mouse-model-of-alzheimer-disease-suggesting-a-correlation-between-ocular-and-brain-pathologies
#11
Lucia Buccarello, Alessandra Sclip, Matteo Sacchi, Anna Maria Castaldo, Ilaria Bertani, Andrea ReCecconi, Silvia Maestroni, Gianpaolo Zerbini, Paolo Nucci, Tiziana Borsello
Recently a range of ocular manifestations such as retinal and lens amyloid-beta accumulation and retinal nerve fiber layer loss have been proposed as potential biomarkers in Alzheimer disease (AD). The TgCRND8 mouse model of AD exhibits age-dependent amyloid β (Aβ) oligomers accumulation and cognitive defects, amyloid plaques and hyperphosphorylated Tau deposition and inflammation. We proved the correlation between ocular pathologies and AD, observing increased levels of p-APP and p-Tau, accumulation of Aβ oligomers in the retina, eye, and optic nerve...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135941/the-small-heat-shock-protein-%C3%AE-crystallin-b-shows-neuroprotective-properties-in-a-glaucoma-animal-model
#12
Fabian Anders, Aiwei Liu, Carolina Mann, Julia Teister, Jasmin Lauzi, Solon Thanos, Franz H Grus, Norbert Pfeiffer, Verena Prokosch
Glaucoma is a neurodegenerative disease that leads to irreversible retinal ganglion cell (RGC) loss and is one of the main causes of blindness worldwide. The pathogenesis of glaucoma remains unclear, and novel approaches for neuroprotective treatments are urgently needed. Previous studies have revealed significant down-regulation of α-crystallin B as an initial reaction to elevated intraocular pressure (IOP), followed by a clear but delayed up-regulation, suggesting that this small heat-shock protein plays a pathophysiological role in the disease...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29135812/optic-nerve-head-drusen-the-relationship-between-intraocular-pressure-and-optic-nerve-structure-and-function
#13
Kaitlyn W Nolan, Michael S Lee, Rohan A Jalalizadeh, Kevin C Firl, Gregory P Van Stavern, Collin M McClelland
OBJECTIVE: To determine whether at the time of diagnosis, the intraocular pressure (IOP) in patients with optic nerve head drusen (ONHD) correlates with the perimetric mean deviation (PMD) and the mean retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT). METHODS: This retrospective chart review included adults with ONHD from 2 academic medical centers. Inclusion criteria were age older than 18 years, definitive diagnosis of ONHD, measurement of IOP, and an automated visual field (VF) within 3 months of diagnosis...
November 9, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29135802/panretinal-photocoagulation-versus-ranibizumab-for-proliferative-diabetic-retinopathy-comparison-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-a-randomized-clinical-trial
#14
Lee M Jampol, Isoken Odia, Adam R Glassman, Carl W Baker, Anjali M Bhorade, Dennis P Han, Glenn J Jaffe, Michele Melia, Neil M Bressler, Angelo P Tanna
PURPOSE: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thickness. METHODS: Eyes with proliferative diabetic retinopathy were randomly assigned to ranibizumab or panretinal photocoagulation. Baseline and annual follow-up spectral domain optical coherence tomography RNFL imaging, optical coherence tomography macular imaging, and automated static perimetry (Humphrey visual field 60-4 algorithm) were performed...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29133640/evaluation-of-spectral-domain-optical-coherence-tomography-parameters-in-ocular-hypertension-preperimetric-and-early-glaucoma
#15
Tuğba Aydogan, BetÜl İlkay Sezgin Akçay, Esra Kardeş, Ahmet Ergin
PURPOSE: The objective of this study is to evaluate the diagnostic ability of retinal nerve fiber layer (RNFL), macular, optic nerve head (ONH) parameters in healthy subjects, ocular hypertension (OHT), preperimetric glaucoma (PPG), and early glaucoma (EG) patients, to reveal factors affecting the diagnostic ability of spectral domain-optical coherence tomography (SD-OCT) parameters and risk factors for glaucoma. METHODS: Three hundred and twenty-six eyes (89 healthy, 77 OHT, 94 PPG, and 66 EG eyes) were analyzed...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29131901/comparison-of-foveal-macular-and-peripapillary-intraretinal-thicknesses-between-autism-spectrum-disorder-and-neurotypical-subjects
#16
José Javier García-Medina, María García-Piñero, Mónica Del-Río-Vellosillo, Jesarán Fares-Valdivia, Ana Belén Ragel-Hernández, Salvador Martínez-Saura, María Dolores Cárcel-López, Vicente Zanon-Moreno, María Dolores Pinazo-Duran, María Paz Villegas-Pérez
Purpose: To compare thicknesses of intraretinal layers segmented by spectral-domain optical coherence tomography (SD-OCT) between autism spectrum disorder (ASD) and neurotypical (NT) individuals. Methods: We performed 2 scans on 108 eyes from 54 participants (27 high-functioning ASD and 27 age- and sex-matched NT subjects): macular fast volume and peripapillary retinal nerve fiber layer (pRNFL). Macula was automatically segmented. The mean foveal and macular thickness of nine different layers and the thickness of nine pRNFL sectors were considered...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29125147/retinal-layers-thickness-changes-following-epiretinal-membrane-surgery
#17
I Hecht, I Yeshurun, E Bartov, A Bar, Z Burgansky-Eliash, A Achiron
PurposeTo evaluate the time course of changes in the thickness of retinal layers after epiretinal membrane (ERM) removal surgery.MethodsA retrospective cohort study of patients following surgery for idiopathic ERM. We used new specialized image analysis software to create a thickness map of each retinal layer and analyzed changes during one year follow-up. Healthy fellow eyes were used as negative controls and the retina prior to surgery as positive control.ResultsTwenty-one patients were included with a mean age of 68±13 years...
November 10, 2017: Eye
https://www.readbyqxmd.com/read/29125019/the-loss-of-macular-ganglion-cells-begins-from-the-early-stages-of-disease-and-correlates-with-brain-atrophy-in-multiple-sclerosis-patients
#18
Anna M Pietroboni, Laura Dell'Arti, Michela Caprioli, Marta Scarioni, Tiziana Carandini, Andrea Arighi, Laura Ghezzi, Giorgio G Fumagalli, Milena A De Riz, Paola Basilico, Annalisa Colombi, Eleonora Benatti, Fabio Triulzi, Elio Scarpini, Francesco Viola, Daniela Galimberti
BACKGROUND: The importance of neurodegeneration in multiple sclerosis (MS) is increasingly well recognized. OBJECTIVES: To evaluate retinal pathology using optical coherence tomography (OCT) and to investigate possible associations between retinal layers' thickness and specific patterns of gray matter volume in patients with a new diagnosis of MS. METHODS: A total of 31 patients underwent OCT scans and brain magnetic resonance imaging. In total, 30 controls underwent the same OCT procedure...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29120977/use-of-a-scan-ultrasound-and-optical-coherence-tomography-to-differentiate-papilledema-from-pseudopapilledema
#19
Roberto Saenz, Han Cheng, Thomas C Prager, Laura J Frishman, Rosa A Tang
SIGNIFICANCE: Differentiating papilledema from pseudopapilledema reflecting tilted/crowded optic discs or disc drusen is critical but can be challenging. Our study suggests that spectral-domain optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness and retrobulbar optic nerve sheath diameter (ONSD) measured by A-scan ultrasound provide useful information when differentiating the two conditions. PURPOSE: To evaluate the use of A-scan ultrasound and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT) in differentiating papilledema associated with idiopathic intracranial hypertension from pseudopapilledema...
November 9, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29120259/signal-alteration-in-the-optic-nerve-head-on-3d-t2-weighted-mri-a-potential-neuroimaging-sign-of-glaucomatous-optic-neuropathy
#20
Jong Yeon Lee, Hyo Jeong Kwon, Su Jin Park, Chungkwon Yoo, Yong Yeon Kim, Eung Yeop Kim
PURPOSE: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm(3)) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively...
November 9, 2017: Current Eye Research
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