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Circadian disruption

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https://www.readbyqxmd.com/read/28711776/sleep-wake-profiles-and-circadian-rhythms-of-core-temperature-and-melatonin-in-young-people-with-affective-disorders
#1
Joanne S Carpenter, Rébecca Robillard, Daniel F Hermens, Sharon L Naismith, Christopher Gordon, Elizabeth M Scott, Ian B Hickie
While disturbances of the sleep-wake cycle are common in people with affective disorders, the characteristics of these disturbances differ greatly between individuals. This heterogeneity is likely to reflect multiple underlying pathophysiologies, with different perturbations in circadian systems contributing to the variation in sleep-wake cycle disturbances. Such disturbances may be particularly relevant in adolescents and young adults with affective disorders as circadian rhythms undergo considerable change during this key developmental period...
July 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28711723/diurnal-cortisol-rhythms-fatigue-and-psychosocial-factors-in-five-year-survivors-of-ovarian-cancer
#2
Michaela G Cuneo, Andrew Schrepf, George M Slavich, Premal H Thaker, Michael Goodheart, David Bender, Steve W Cole, Anil K Sood, Susan K Lutgendorf
Fatigue is a challenge in ovarian cancer survivorship and greatly impacts quality of life. In other cancer populations, fatigue has been associated with abnormal diurnal cortisol patterns. However, little is known about biological and behavioral factors in 5+-year ovarian cancer survivors and potential mechanisms underlying persistent fatigue have not been investigated in this population. Moreover, relationships between neuroendocrine and psychosocial factors in 5+-year ovarian cancer survivors have not been studied...
June 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28710114/circadian-rhythm-disruption-impairs-tissue-homeostasis-and-exacerbates-chronic-inflammation-in-the-intestine
#3
René Pagel, Florian Bär, Torsten Schröder, Annika Sünderhauf, Axel Künstner, Saleh M Ibrahim, Stella E Autenrieth, Kathrin Kalies, Peter König, Anthony H Tsang, Dominik Bettenworth, Senad Divanovic, Hendrik Lehnert, Klaus Fellermann, Henrik Oster, Stefanie Derer, Christian Sina
Endogenous circadian clocks regulate 24 h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy, immunohistochemistry, and bromodeoxyuridine pulse-chase experiments. TNF-α was injected intraperitoneally, with or without necrostatin-1, into Per1/2 mice or rhythmic and externally desynchronized WT mice to study intestinal epithelial cell death...
July 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28709906/effects-of-feeding-time-on-daily-rhythms-of-neuropeptide-and-clock-gene-expression-in-the-rat-hypothalamus
#4
Dawei Wang, Anne-Loes Opperhuizen, Jane Reznick, Nigel Turner, Yan Su, Gregory J Cooney, Andries Kalsbeek
Shiftworkers are exposed to several adverse health conditions, one being eating at night. Food consumption at an unnatural time-of-day is thought to be one of the main factors responsible for the increased risk of developing metabolic diseases, such as obesity and diabetes mellitus. The underlying mechanism is considered to include disruption of the circadian organization of physiology, leading to disruption of metabolism. When food is consumed at night, the hypothalamus, a brain region central to homeostasis, receives contradicting input from the central clock and the systemic circulation...
July 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28708429/effects-of-altered-photoperiod-on-circadian-clock-and-lipid-metabolism-in-rats
#5
Xiaoxian Xie, Binggong Zhao, Liangfeng Huang, Qichen Shen, Lingyan Ma, Yangyang Chen, Tao Wu, Zhengwei Fu
Disruption of circadian clock timekeeping due to changes in the photoperiod enhances the risk of lipid metabolism disorders and metabolic syndrome. However, the effects of altered photoperiods on the circadian clock and lipid metabolism are not well understood. To explore the effects of altered photoperiods, we developed a rat model where rats were exposed to either short-day or long-day conditions. Our findings demonstrated that altered photoperiods mediated circadian clocks by partly disrupting rhythmicity and shifting phase values of clock genes...
July 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28707432/mechanisms-of-breast-cancer-risk-in-shift-workers-association-of-telomere-shortening-with-the-duration-and-intensity-of-night-work
#6
Johanna Samulin Erdem, Heidi Ødegaard Notø, Øivind Skare, Jenny-Anne S Lie, Marte Petersen-Øverleir, Edyta Reszka, Beata Pepłońska, Shanbeh Zienolddiny
Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work-related breast cancer...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28699894/cancer-testis-antigen-piwil2-suppresses-circadian-rhythms-by-regulating-the-stability-and-activity-of-bmal1-and-clock
#7
Yilu Lu, Xulei Zheng, Wei Hu, Shasha Bian, Zhiwei Zhang, Dachang Tao, Yunqiang Liu, Yongxin Ma
Circadian rhythms are regulated by transcriptional and post-translational feedback loops generated by appropriate functions of clock proteins. Rhythmic degradation of the circadian clock proteins is critical for maintenance of the circadian oscillations. Notably, circadian clock does not work during spermatogenesis and can be disrupted in tumors. However, the underlying mechanism that suppresses circadian rhythms in germ cells and cancer cells remains largely unknown. Here we report that the cancer/testis antigen PIWIL2 can repress circadian rhythms both in the testis and cancer cells...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699174/inherited-variation-in-circadian-rhythm-genes-and-risks-of-prostate-cancer-and-three-other-cancer-sites-in-combined-cancer-consortia
#8
Fangyi Gu, Han Zhang, Paula L Hyland, Sonja Berndt, Susan M Gapstur, William Wheeler, Christopher I Amos, Stephane Bezieau, Heike Bickeböller, Hermann Brenner, Paul Brennan, Jenny Chang-Claude, David V Conti, Jennifer Ann Doherty, Stephen B Gruber, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, Richard S Houlston, Rayjean J Hung, Mark A Jenkins, Peter Kraft, Kate Lawrenson, James McKay, Sarah Markt, Lorelei Mucci, Catherine M Phelan, Conghui Qu, Angela Risch, Mary Anne Rossing, H-Erich Wichmann, Jianxin Shi, Eva Schernhammer, Kai Yu, Maria Teresa Landi, Neil E Caporaso
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)...
July 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28698578/dopamine-2-receptor-activation-entrains-circadian-clocks-in-mouse-retinal-pigment-epithelium
#9
Kenkichi Baba, Jason P DeBruyne, Gianluca Tosini
Many of the physiological, cellular, and molecular rhythms that are present within the eye are under the control of circadian clocks. Experimental evidence suggests that the retinal circadian clock, or its output signals (e.g., dopamine and melatonin), may contribute to eye disease and pathology. We recently developed a retinal pigment ephithelium (RPE)-choroid preparation to monitor the circadian clock using PERIOD2 (PER2)::LUC knock-in mouse. In this study we report that dopamine, but not melatonin, is responsible for entrainment of the PER2::LUC bioluminescence rhythm in mouse RPE-choroid...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693506/intracellular-high-cholesterol-content-disorders-the-clock-genes-apoptosis-related-genes-and-fibrinolytic-related-genes-rhythmic-expressions-in-human-plaque-derived-vascular-smooth-muscle-cells
#10
Changpo Lin, Xiao Tang, Lirong Xu, Ruizhe Qian, Zhenyu Shi, Lixin Wang, Tingting Cai, Dong Yan, Weiguo Fu, Daqiao Guo
BACKGROUND: The clock genes are involved in regulating cardiovascular functions, and their expression disorders would lead to circadian rhythm disruptions of clock-controlled genes (CCGs), resulting in atherosclerotic plaque formation and rupture. Our previous study revealed the rhythmic expression of clock genes were attenuated in human plaque-derived vascular smooth muscle cells (PVSMCs), but failed to detect the downstream CCGs expressions and the underlying molecular mechanism. In this study, we examined the difference of CCGs rhythmic expression between human normal carotid VSMCs (NVSMCs) and PVSMCs...
July 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28689605/circadian-disruptions-in-the-myshkin-mouse-model-of-mania-are-independent-of-deficits-in-suprachiasmatic-molecular-clock-function
#11
Joseph W S Timothy, Natasza Klas, Harshmeena R Sanghani, Taghreed Al-Mansouri, Alun T L Hughes, Greer S Kirshenbaum, Vincent Brienza, Mino D C Belle, Martin R Ralph, Steven J Clapcote, Hugh D Piggins
BACKGROUND: Alterations in environmental light and intrinsic circadian function have strong associations with mood disorders. The neural origins underpinning these changes remain unclear, although genetic deficits in the molecular clock regularly render mice with altered mood-associated phenotypes. METHODS: A detailed circadian and light-associated behavioral characterization of the Na(+)/K(+)-ATPase α3 Myshkin (Myk/+) mouse model of mania was performed. Na(+)/K(+)-ATPase α3 does not reside within the core circadian molecular clockwork, but Myk/+ mice exhibit concomitant disruption in circadian rhythms and mood...
May 20, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28687451/possible-roles-for-glucocorticoid-signalling-in-breast-cancer
#12
REVIEW
Keely M McNamara, Ayako Kannai, Hironobu Sasano
Our understanding of breast cancer biology, and our ability to manipulate breast cancers have grown exponentially in the last 20 years. Much of that expansion has focused on the roles of steroids in driving these neoplasms. Initially this research focused on estrogens and progesterone receptors, and more recently on androgen actions in breast cancers. This review aims to make the case for glucocorticoids as the next essential steroid subclass that contributes significantly to our understanding of steroidogenic regulation of these neoplasms...
July 4, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28687372/effects-of-a-free-choice-high-fat-high-sugar-diet-on-brain-per2-and-bmal1-protein-expression-in-mice
#13
Aurea Blancas-Velazquez, Susanne E la Fleur, Jorge Mendoza
The suprachiasmatic nucleus (SCN) times the daily rhythms of behavioral processes including feeding. Beyond the SCN, the hypothalamic arcuate nucleus (ARC), involved in feeding regulation and metabolism, and the epithalamic lateral habenula (LHb), implicated in reward processing, show circadian rhythmic activity. These brain oscillators are functionally coupled to coordinate the daily rhythm of food intake. In rats, a free choice high-fat high-sugar (fcHFHS) diet leads to a rapid increase of calorie intake and body weight gain...
July 5, 2017: Appetite
https://www.readbyqxmd.com/read/28683290/cry1-2-selectively-repress-ppar%C3%AE-and-limit-exercise-capacity
#14
Sabine D Jordan, Anna Kriebs, Megan Vaughan, Drew Duglan, Weiwei Fan, Emma Henriksson, Anne-Laure Huber, Stephanie J Papp, Madelena Nguyen, Megan Afetian, Michael Downes, Ruth T Yu, Anastasia Kralli, Ronald M Evans, Katja A Lamia
Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exercise endurance. We show here that the circadian repressors CRY1 and CRY2 function as co-repressors for PPARδ. Cry1(-/-);Cry2(-/-) myotubes and muscles exhibit elevated expression of PPARδ target genes, particularly in the context of exercise...
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28682785/artificial-light-at-night-a-novel-lifestyle-risk-factor-for-metabolic-disorder-and-cancer-morbidity
#15
REVIEW
Abed E Zubidat, Abraham Haim
Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important role in the development of these syndromes. However, we still poorly understand the molecular mechanism underlying the association between circadian disruption and the modern health syndromes...
July 26, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28680128/endogenous-melatonin-promotes-rhythmic-recruitment-of-neutrophils-toward-an-injury-in-zebrafish
#16
Da-Long Ren, Cheng Ji, Xiao-Bo Wang, Han Wang, Bing Hu
Neutrophil recruitment to injured tissue appears to be an evolutionarily conserved strategy for organisms to fight against exogenous insults. Recent studies have shown rhythmic migration of neutrophils and several factors, including melatonin, have been implicated in regulating this rhythmic migration. The mechanisms underlying how endogenous melatonin regulates rhythmic neutrophils migration, however, are unclear. Here we generated a zebrafish annat2 mutant that lacks endogenous melatonin and, subsequently, a Tg(lyz:EGFP);aanat2 (-/-) transgenic line that allows for monitoring neutrophils migration visually in live zebrafish...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676736/lower-in-vivo-myo-inositol-in-the-anterior-cingulate-cortex-correlates-with-delayed-melatonin-rhythms-in-young-persons-with-depression
#17
Rébecca Robillard, Jim Lagopoulos, Daniel F Hermens, Sharon L Naismith, Naomi L Rogers, Django White, Joanne S Carpenter, Manreena Kaur, Elizabeth M Scott, Ian B Hickie
Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3 ± 3.8 years old). Healthy controls were recruited from the community (21...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28674930/trojan-horse-strategy-for-non-invasive-interference-of-clock-gene-in-the-oyster-crassostrea-gigas
#18
Laura Payton, Mickael Perrigault, Jean-Paul Bourdineaud, Anjara Marcel, Jean-Charles Massabuau, Damien Tran
RNA interference is a powerful method to inhibit specific gene expression. Recently, silencing target genes by feeding has been successfully carried out in nematodes, insects, and small aquatic organisms. A non-invasive feeding-based RNA interference is reported here for the first time in a mollusk bivalve, the pacific oyster Crassostrea gigas. In this Trojan horse strategy, the unicellular alga Heterocapsa triquetra is the food supply used as a vector to feed oysters with Escherichia coli strain HT115 engineered to express the double-stranded RNA targeting gene...
July 3, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28674176/effects-of-chronic-social-defeat-stress-on-sleep-and-circadian-rhythms-are-mitigated-by-kappa-opioid-receptor-antagonism
#19
Audrey M Wells, Elysia Ridener, Clinton A Bourbonais, Woori Kim, Harry Pantazopoulos, F Ivy Carroll, Kwang-Soo Kim, Bruce M Cohen, William A Carlezon
Stress plays a critical role in the neurobiology of mood and anxiety disorders. Sleep and circadian rhythms are affected in many of these conditions. Here we examined the effects of chronic social defeat stress (CSDS), an ethological form of stress, on sleep and circadian rhythms. We exposed male mice implanted with wireless telemetry transmitters to a 10-day CSDS regimen known to produce anhedonia (a depressive-like effect) and social avoidance (an anxiety-like effect). Electroencephalography (EEG), electromyography (EMG), body temperature, and locomotor activity data were collected continuously during the CSDS regimen and a 5-day recovery period...
July 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28671110/alterations-of-clock-gene-rna-expression-in-brain-regions-of-a-triple-transgenic-model-of-alzheimer-s-disease
#20
Francesco Bellanti, Giuseppina Iannelli, Maria Blonda, Rosanna Tamborra, Rosanna Villani, Adele Romano, Silvio Calcagnini, Gianluigi Mazzoccoli, Manlio Vinciguerra, Silvana Gaetani, Anna Maria Giudetti, Gianluigi Vendemiale, Tommaso Cassano, Gaetano Serviddio
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian rhythmicity is regulated by endogenous clock genes and a number of external Zeitgebers, including light. This study investigated the light induced changes in the expression of clock genes in a triple transgenic model of AD (3×Tg-AD) and their wild type littermates (Non-Tg). Changes in gene expression were evaluated in four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex and brainstem¾of 6- and 18-month-old Non-Tg and 3×Tg-AD mice after 12 h exposure to light or darkness...
June 24, 2017: Journal of Alzheimer's Disease: JAD
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