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high sensibilization

Shengdong Wang, Hengyuan Li, Chenyi Ye, Peng Lin, Binghao Li, Wei Zhang, Lingling Sun, Zhan Wang, Deting Xue, Wangsiyuan Teng, Xingzhi Zhou, Nong Lin, Zhaoming Ye
The long-term survival of osteosarcoma has remained unchanged in the last several decades. Immunotherapy is proved to be a promising therapeutic strategy against osteosarcoma, especially for those with metastasis. Our previous study explored the sensibilization of zoledronate (ZOL) in γδ T cell-mediated cytotoxicity against osteosarcoma, but we have not yet elucidated the specific mechanism. Besides, high concentration is required to achieve these effects, whereas plasma ZOL concentration declines rapidly in the circulation...
2018: Frontiers in Immunology
Xuan Chen, Jie Li, Shuang Hu, Xiaohong Bai, Haodong Zhao, Yi Zhang
A new fibroin/dodecanol floating solidification microextraction, coupled with high performance liquid chromatography, was developed and applied for enrichment and quantification of the trace flavonoids in traditional Chinese medicine and biological samples. Also, fibroin sensibilization mechanism was described, and influence of sample matrix to enrichment factor was investigated. In this method, a homogeneous fibroin/dodecanol of dispersed solution was employed as microextraction phase to flavonoids (myricetin, quercetin, isorhamnetin, chrysin, kaempferide), the several critical parameters affecting the performance, such as organic extractant, amount of fibroin in organic extractant, volume of extraction phase, dispersant, salt concentration, pH of sample phase, stirring rate, extraction time, and volume of sample phase were tested and optimized...
January 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Paola Savoia, Tommaso Deboli, Alberto Previgliano, Paolo Broganelli
Basal cell carcinoma (BCC) is the most common cancer in individuals with fair skin type (I-II) and steadily increasing in incidence (70% of skin malignancy). It is locally invasive but metastasis is usually very rare, with an estimated incidence of 0.0028%-0.55%. Conventional therapy is surgery, especially for the H region of the face and infiltrative lesions; in case of inoperable tumors, radiotherapy is a valid option. Recently, topical photodynamic therapy (PDT) has become an effective treatment in the management of superficial and small nodular BCC...
2015: International Journal of Molecular Sciences
E M Zaĭtsev, N Iu Mertsalova, M V Britsina, M N Ozeretskovskaia, I G Bazhanova, A S Shinkarev, A V Poddubikov
AIM: Study specific activity and safety ofvaccine preparations based on circulating B. pertussis strains with currently predominating allele variants of pertussis toxin (ptxA1) and pertactin (prn2) genes. MATERIALS AND METHODS: B. pertussis strains isolated from pertussis patients in Moscow in 2001-2010 were grown in dense and liquid media. The content of separate antigens in B. pertussis strains was determined by EIA. Immunogenicity and safety of the preparations was determined in F1(CBAxC57B16) line mice...
July 2014: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Julie Bourgin, Marie-Odile Krebs
The onset of schizophrenic disorders generally occurs in late adolescence/early adulthood. However, in 75% of the cases, the onset is preceded by a prodromal stage. Subjects concerned by these prodromal symptoms are defined at "high risk" for psychosis (30% of conversion to psychosis in the next year). Early detection programs aim at improving the recognition of the prodromal symptoms in order to develop appropriate early interventions that will delay or prevent conversion to psychosis or reduce the duration of untreated psychosis (DUP)...
March 2013: La Revue du Praticien
B Marengo, C G De Ciucis, R Ricciarelli, A L Furfaro, R Colla, E Canepa, N Traverso, U M Marinari, M A Pronzato, C Domenicotti
Neuroblastoma (NB) is the second most common solid pediatric tumor and is characterized by clinical and biological heterogeneity, and stage-IV of the disease represents 50% of all cases. Considering the limited success of present chemotherapy treatment, it has become necessary to find new and effective therapies. In this context, our approach consists of identifying and targeting key molecular pathways associated with NB chemoresistance. This study has been carried out on three stage-IV NB cell lines with different status of MYCN amplification...
April 11, 2013: Cell Death & Disease
M Alcaraz, A Olivares, D Armero, M Alcaraz-Saura, D Achel
INTRODUCTION: Zoledronic acid (Z) is a bisphosphonate used in hypercalcaemia-related cancer, in complications for bone metastasis and in postmenopausal osteoporosis and it has been related to osteoradionecrosis, especially when associated with radiation to the head and neck structures. OBJECTIVES: To determine the radiosensitization capacity of zoledronic acid in the combined treatment with ionizing radiation (IR) by evaluating its genotoxic and cytotoxic capacities in non-tumoral cells...
April 2013: Clinical & Translational Oncology
A V Semenova, T A Minenkova, Iu L Mizernitskiĭ
The high mobilization activity of neutrophils as a capacity of momentary feed-back reaction to factually any external stimuli, make it possible to use them in various diagnostic systems in vitro. Among them is the automated test system of chemiluminescent detection of functional activity of peripheral blood neutrophils in parallel response to luminol, opsonizing zymosan and different antigens. This approach makes it possible to evaluate the initial and induced activity of phagocytes and its dynamics in case of adding in vitro to test system of one or another allergen...
October 2012: Klinicheskaia Laboratornaia Diagnostika
I I Pelevina, A V Aleshchenko, M M Antoshchina, O V Kudriashova, N I Riabchenko, A V Akleev
When the adaptive response (AR) was studied on human blood lymphocytes, a new dependence was discovered. This dependence defines the direction of the radiosensitivity change after a low dose of irradiation. Using micronucleus (MN) test with cytochalasin B the dependence between the cell reaction after low level irradiation and radiosensititvity (the effect after irradiation at the dose of 1 Gy) was observed. The negative correlation between the frequency of AR manifestation, sensibilization, intermediate links and radiosensitivity was discovered...
September 2012: Radiatsionnaia Biologiia, Radioecologiia
Katrin Waurick
Among clinical benefits like reduction in blood loss, faster postoperative recovery of gastrointestinal and lung function, lower rate of perioperative complications and less postoperative pain level, cost reduction by shortening of hospital stay plays a pivotal role for high incidence of laparoscopic surgery.Elevated intraabdominal pressure due to creation of pneumoperitoneum induces various pathophysiologic changes. Most of these changes are clinical inapparent in case of appropriate anesthesiologic management...
October 2012: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Sebastián A Ferraro, Gustavo Curutchet, Deborah R Tasat
The Reconquista River (RR), one of the most polluted watercourses in Argentina, receives effluent discharges from heavily industrialized and highly populated settlements. During winter and summer, the floodplain remains dry, producing the oxidation of sulfide and organic matter present in the sediment, making heavy metals more bioaccessible. Dispersion of this sediment occurs, and thus harmful effects on the pulmonary health of residents and workers inhabiting the RR bank may take place. The authors characterized the sediment particles of the RR (RR-PM) morphologically by scanning electron microscopy and its elemental composition by energy dispersive X-ray spectroscopy (EDX) and Community Bureau of Reference (BCR) sequential extraction...
September 2012: Environmental Toxicology and Chemistry
Sofía Tziraki
INTRODUCTION. Cannabis is an illegal drug in wide use nowadays, mainly for recreational purposes. It is considered one of the less harmful drugs, partly due to the large amount of information to which most people have access. However, the scientific literature could reveal important clues to the contrary. AIM. To gather and resume updated scientific data from different fields (clinical psychology, neurobiology, neuroimaging...) about the effects and consequences of the chronic use of cannabis. DEVELOPMENT. Evidence concerning the mental disorders and neuropsychological impairment associated the most to the chronic use is presented along with comments on the possible underlying neurobiological mechanisms, and the most important risk factors are also described...
June 16, 2012: Revista de Neurologia
Ana P Fernandez, Julia Serrano, Miguel A Amorim, Andrea Pozo-Rodrigalvarez, Ricardo Martinez-Murillo
Gliomas, defined as tumors of glial origin, represent between 2-5 percent of all adult cancer and comprise the majority of primary brain tumors. Infiltrating gliomas, with an incidence of more than 40 percent of brain tumors, are the most common and destructive primary brain tumors for which conventional therapies have not significantly improved patient outcome. In fact, patients suffering from malignant gliomas have poor prognoses and the majority have local tumor recurrence after treatment. Tumor growth and spread of tumor cells depend basically upon angiogenesis and on functional abnormalities of tumor cells in the control of apoptosis, as they are paradigmatic for their intrinsic resistance to multiple pro-apoptotic stimuli...
November 2011: CNS & Neurological Disorders Drug Targets
É É Eritsian
The data is presented concerning the implementation of nano-particles of aurum in the diagnostics of systemic lupus erythematosus. It is demonstrated that nano-particles sensibilized by deoxyribonucleoprotein are able to detect the specific antibodies--the known markers of systemic lupus erythematosus. To optimize the reaction various approaches were applied. The comparative analysis was made including latex-agglutination technique, immune-enzyme analysis and fluorescence immunoassay. It is demonstrated that the given system is characterized by very high sensibility to determine the specific antibodies and hence can be effectively applied in diagnostics process...
July 2011: Klinicheskaia Laboratornaia Diagnostika
Julia Märk, Max Andre, Martin Karner, Christian W Huck
NIR spectroscopy was applied to develop a fast and reliable quality control system for a pharmaceutical substance to support information obtained through PAT surveillance of its manufacturing process. After calculating different quantitative calibrations of the substance's key quality parameters, a general classification model has been derived to capture the over-all product grade. The final spectral quality conformity model consisting of 96 representative batches - covering high process variability - was sensibilized toward five important quality parameters by their incorporation as PLS responses...
October 2010: European Journal of Pharmaceutics and Biopharmaceutics
G P Kozinets, O I Osadchaia, A M Boiarskaia, V P Tsygankov, N P Isaenko, Iu A Solodkiĭ
Clinical efficacy of Ronem preparation was studied in injured persons, suffering deep burns. High efficacy of the preparation in an acute period of the burn disease was established concerning the reduction in severity of the syndrome of systemic inflammatory answer clinical signs, the infection complications prophylaxis, microbal sensibilization lowering and preservation of natural detoxication systems on subcompensation level.
October 2008: Klinichna Khirurhiia
Mario Cavazos Galván, Belinda Guerrero Núñez, Daniel Ramírez Aragón
BACKGROUND: In Mexico there are few research papers dealing with mites and cockroaches sensibilizing in patients suffering from respiratory allergies and even less susceptibility comparative studies to the same between cities having different climatic and geographic characteristics. OBJECTIVES: To research in a prospective study skin sensibilizing to eighy different mites and two cockroaches species in patients with respiratory allergies in three cities of Mexico: Monterrey, NL, Tampico, Tamps...
November 2008: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
A Ferro, S Cinquetti, T Menegon, G Napoletano, L Bertoncello, M Valsecchi
Steps toward overcoming mandatory vaccination policy follow two main tracks: scientific and administrative. Scientific course checks starting conditions of the project in Veneto Region and monitors the effects of policy. Thanks to sensibilization regional programs and partecipation to national campaigns of vaccination, Veneto Region has achieved high coverage for all actively promoted vaccinations. Specific projects has been implemented in order to improve vaccination system quality, particularly with regard to infectious diseases and vaccine adverse events surveillance, training workers and informatization...
May 2008: Annali di Igiene: Medicina Preventiva e di Comunità
G Pónyai, B Hidvégi, I Németh, A Sas, E Temesvári, S Kárpáti
BACKGROUND: Atopic dermatitis (AD) is a clinically well-defined, chronic-intermittant, genetically predisposed skin disease. The increasing number of adult cases observed in the last years has turned the attention to ascertaining factors eliciting skin symptoms. Studies have revealed numerous environmental components (e.g. contact and aeroallergens) that may play an important role in sustaining the symptoms. The aim of the study was to search for contact allergens and aeroallergens triggering the skin disease in adult AD patients...
November 2008: Journal of the European Academy of Dermatology and Venereology: JEADV
Kezong Qi, Liangqiang Zhu, Guoren Sun, Zuhao Shi, Kaisong Peng
A method of high performance liquid chromatography with post-column derivatization and terbium sensitized fluorescence for simultaneous determination of residues of ciprofloxacin, norfloxacin and enrofloxacin in chicken was established, based on the effect that Tb3+ can sensibilize fluorescence of fluoroquinolones. Under the optimal chromatographic condition, three fluoroquinolones were separated on a C18 column with 0.05 mol/L acetic acid/acetate buffer-acetonitrile (89:11, v/v) as the mobile phase, and at a flow rate of 0...
July 2007: Se Pu, Chinese Journal of Chromatography
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