keyword
MENU ▼
Read by QxMD icon Read
search

Brain AND criticality

keyword
https://www.readbyqxmd.com/read/29909130/immunohistochemical-detection-of-the-vomiting-inducing-monoamine-neurotransmitter-serotonin-and-enterochromaffin-cells-in-the-intestines-of-conventional-or-gnotobiotic-gn-pigs-infected-with-porcine-epidemic-diarrhea-virus-pedv-and-serum-cytokine-responses-of
#1
Kwonil Jung, Ayako Miyazaki, Linda J Saif
Serotonin is a critical monoamine neurotransmitter molecule stored and released from enterochromaffin (EC) cells into the gut submucosa, transmitting the vomiting signal to the brain. We studied one mechanism by which vomiting is induced in pigs infected with porcine epidemic diarrhea virus (PEDV) by characterization of swine EC cells by immunohistochemistry. Conventional or gnotobiotic (Gn) 9-day-old pigs [PEDV-inoculated (n = 12); Mock (n = 14)] were inoculated orally (8.9-9.2 log10 genomic equivalents/pig) with PEDV PC21A strain or mock...
June 12, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29908715/some-neuroanatomical-insights-to-impulsive-aggression-in-schizophrenia
#2
REVIEW
Marcel P Leclerc, Christina Regenbogen, Roy H Hamilton, Ute Habel
Patients with schizophrenia are at increased risk of engaging in violence towards others, compared to both the general population and most other patient groups. We have here explored the role of cortico-limbic impairments in schizophrenia, and have considered these brain regions specifically within the framework of a popular neuroanatomical model of impulsive aggression. In line with this model, evidence in patients with aggressive schizophrenia implicated structural deficits associated with impaired decision-making, emotional control and evaluation, and social information processing, especially in the orbitofrontal and ventrolateral prefrontal cortex...
June 13, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29908254/the-neurotoxin-diethyl-dithiophosphate-impairs-glutamate-transport-in-cultured-bergmann-glia-cells
#3
Tatiana N Olivares-Bañuelos, Isabel Martínez-Hernández, Luisa C Hernández-Kelly, Donají Chi-Castañeda, Libia Vega, Arturo Ortega
Glutamate, the main excitatory neurotransmitter in the vertebrate Central Nervous System, is involved in almost every aspect of brain physiology, and its signaling properties are severely affected in most neurodegenerative diseases. This neurotransmitter has to be efficiently removed from the synaptic cleft in order to prevent an over-stimulation of glutamate receptors that leads to neuronal death. Specific sodium-dependent membrane transporters, highly enriched in glial cells, elicit the clearance of glutamate...
June 13, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29908165/consequences-of-tuning-network-function-by-tonic-and-phasic-locus-coeruleus-output-and-stress-regulating-detection-and-discrimination-of-peripheral-stimuli
#4
David M Devilbiss
Flexible and adaptive behaviors have evolved with increasing complexity and numbers of neuromodulator systems. The neuromodulatory locus coeruleus-norepinephrine (LC-NE) system is central to regulating cognitive function in a behaviorally-relevant and arousal-dependent manner. Through its nearly ubiquitous efferent projections, the LC-NE system acts to modulate neuron function on a cell-by-cell basis and exert a spectrum of actions across different brain regions to optimize target circuit function. As LC neuron activity, NE signaling, and arousal level increases, cognitive performance improves over an inverted-U shaped curve...
June 13, 2018: Brain Research
https://www.readbyqxmd.com/read/29908127/sphingolipid-metabolism-an-ambiguous-regulator-of-autophagy-in-the-brain
#5
Gerhild van Echten-Deckert, Shah Alam
In mammals, the brain exhibits the highest lipid content in the body next to adipose tissue. Complex sphingolipids are characteristic compounds of neuronal membranes. Vital neural functions including information flux and transduction occur along these membranes. It is therefore not surprising that neuronal function and survival is dependent on the metabolism of these lipids. Autophagy is a critical factor for the survival of post-mitotic neurons. On one hand it fulfils homeostatic and waste-recycling functions and on the other hand it constitutes an effective strategy to eliminate harmful proteins that cause neuronal death...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29907235/rapid-valproic-acid-induced-modulation-of-the-traumatic-proteome-in-a-porcine-model-of-traumatic-brain-injury-and-hemorrhagic-shock
#6
Michael Weykamp, Vahagn C Nikolian, Isabel S Dennahy, Gerald A Higgins, Patrick E Georgoff, Henriette Remmer, Mohamed H Ghandour, Hasan B Alam
BACKGROUND: Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma. Although VPA is known to modulate transcription, its ability to reduce mortality within minutes of administration suggests involvement of a rapid, posttranslational mechanism. We hypothesized that VPA treatment would cause proteomic changes within minutes of treatment including quantitative and/or posttranslational differences in structural and/or effector proteins...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906551/lateral-inhibition-is-a-neural-mechanism-underlying-mismatch-negativity
#7
Feng Gu, Lena Wong, Fei Chen, Wan-Ting Huang, Lei Wang, A-Xu Hu
The human auditory change detection response known as mismatch negativity (MMN) is an auditory event-related potential that has been extensively used to investigate various aspects of human brain function and dysfunction. However, two competing views of the neural mechanism that underlie MMN have been a subject of debate for decades. The sensory memory hypothesis claims that the MMN reflects sensory memory-based change detection. The adaptation hypothesis argues that neural adaptation and lateral inhibition can fully explain the MMN...
June 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29906485/deciphering-brain-specific-transcriptomic-expression-of-ezr-rad-and-msn-genes-in-the-development-of-mus-musculus
#8
Syed Aoun Ali, Deeba N Baig
Ezrin, Radixin and Moesin (ERM) are critical membranous component involved in cross-linking of actin filaments. Moesin (Msn) is recognized as a pivotal protein involved in regulation of cell signalling events associated with the maintenance of epithelial integrity, actin organization and polarity. Radixin (Rad) is known to cell-to-cell adherens junction as a barbed end-capping protein whereas ezrin (Ezr) is recognized at cell adhesion, motility, apoptosis and phagocytosis. The current study for the first time reports the transcriptional and RNA secondary structural variations among brain-specific ERM genes...
June 12, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29905901/the-search-of-canonical-explanations-for-the-cerebral-cortex
#9
Alessio Plebe
This paper addresses a fundamental line of research in neuroscience: the identification of a putative neural processing core of the cerebral cortex, often claimed to be "canonical". This "canonical" core would be shared by the entire cortex, and would explain why it is so powerful and diversified in tasks and functions, yet so uniform in architecture. The purpose of this paper is to analyze the search for canonical explanations over the past 40 years, discussing the theoretical frameworks informing this research...
June 15, 2018: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29905772/nrf2-deficiency-exacerbates-obesity-induced-oxidative-stress-neurovascular-dysfunction-blood-brain-barrier-disruption-neuroinflammation-amyloidogenic-gene-expression-and-cognitive-decline-in-mice-mimicking-the-aging-phenotype
#10
Stefano Tarantini, M Noa Valcarcel-Ares, Andriy Yabluchanskiy, Zsuzsanna Tucsek, Peter Hertelendy, Tamas Kiss, Tripti Gautam, Xin A Zhang, William E Sonntag, Rafael de Cabo, Eszter Farkas, Michael H Elliott, Michael T Kinter, Ferenc Deak, Zoltan Ungvari, Anna Csiszar
Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms through which aging and obesity interact to remain elusive. Previously, we have shown that Nrf2 signaling plays a critical role in microvascular resilience to obesity and that aging is associated with progressive Nrf2 dysfunction, promoting microvascular impairment...
June 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29905673/blood-brain-barrier-dysfunction-after-smoke-inhalation-injury-with-and-without-skin-burn
#11
Anita C Randolph, Satoshi Fukuda, Koji Ihara, Perenlei Enkhbaatar, Maria-Adelaide Micci
Only a handful of published reports exist today that describe neurological complications following smoke inhalation injury. In this study, we characterize acute pathophysiological changes in the brain of sheep exposed to smoke inhalation, with- and without third-degree skin burn that models the injuries sustained by human victims of fire accidents. Blood-brain barrier integrity and hemorrhage were analyzed throughout the brain using specific histological stains: Hematoxylin & Eosin, Luxol fast blue, Periodic acid-Schiff (PAS), and Martius, Scarlet and Blue (MSB)...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29905566/-evaluation-of-neuroprotective-activity-of-complex-impact-of-magnesium-of-sulfate-lamotrygine-and-n-acetylcysteine-under-conditions-of-combined-normobaric-hypoxia-with-ligation-of-right-carotid-artery-in-rats
#12
M Samsonia, M Kandelaki, N Baratashvili
Cerebrovascular diseases of ischemic origin still remain the leading cause of death and disability of the population. In acute cerebral discirculation conditions, anaerobic glycolysis is activated, ATP formation rate decreases, the ion pumps work is disrupted and superoxide radicals are formed. Eventually, ionic asymmetry leads to the cytotoxic and vasogenic brain edema. Therefore, it is extremely important to induce simultaneous (complex) effect of medications on the key mechanisms of neuronal damage in process of survival of brain cells during acute ischemic stroke...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905157/idiopathic-generalised-epilepsies-of-adult-onset-a-reappraisal-and-literature-review
#13
José Pimentel, Sara Varanda, Pedro Guimarães, Fernando Lopes da Silva
Idiopathic generalised epilepsies are characterised by widespread, symmetric, bilateral spike-and-wave discharges on EEG. Onset typically occurs in children and adolescents, but may also start in adulthood. These forms of adult onset constitute the focus of this review. A critical analysis of the medical literature was conducted through a narrative review search of PubMed and Medline databases. Cases of idiopathic generalised epilepsies with adult onset, in general, are not considered to be independent nosological entities...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29904812/review-of-eeg-based-pattern-classification-frameworks-for-dyslexia
#14
Harshani Perera, Mohd Fairuz Shiratuddin, Kok Wai Wong
Dyslexia is a disability that causes difficulties in reading and writing despite average intelligence. This hidden disability often goes undetected since dyslexics are normal and healthy in every other way. Electroencephalography (EEG) is one of the upcoming methods being researched for identifying unique brain activation patterns in dyslexics. The aims of this paper are to examine pros and cons of existing EEG-based pattern classification frameworks for dyslexia and recommend optimisations through the findings to assist future research...
June 15, 2018: Brain Informatics
https://www.readbyqxmd.com/read/29904441/ischemic-modified-albumin-predicts-critical-coronary-artery-disease-in-unstable-angina-pectoris-and-non-st-elevation-myocardial-infarction
#15
Abdullah Orhan Demirtas, Turgut Karabag, Derya Demirtas
Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29902588/anterior-paracingulate-and-cingulate-cortex-mediates-the-effects-of-cognitive-load-on-speech-sound-discrimination
#16
Silvia P Gennari, Rebecca E Millman, Mark Hymers, Sven L Mattys
Perceiving speech while performing another task is a common challenge in everyday life. How the brain controls resource allocation during speech perception remains poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated the effect of cognitive load on speech perception by examining brain responses of participants performing a phoneme discrimination task and a visual working memory task simultaneously. The visual task involved holding either a single meaningless image in working memory (low cognitive load) or four different images (high cognitive load)...
June 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29902500/the-role-of-neuro-epithelial-like-and-radial-glial-stem-and-progenitor-cells-in-development-plasticity-and-repair
#17
REVIEW
Benjamin W Lindsey, Zachary J Hall, Aurélie Heuzé, Jean-Stéphane Joly, Vincent Tropepe, Jan Kaslin
Neural stem and progenitor cells (NSPCs) are the primary source of new neurons in the brain and serve critical roles in tissue homeostasis and plasticity throughout life. Within the vertebrate brain, NSPCs are located within distinct neurogenic niches differing in their location, cellular composition, and proliferative behaviour. Heterogeneity in the NSPC population is hypothesized to reflect varying capacities for neurogenesis, plasticity and repair between different neurogenic zones. Since the discovery of adult neurogenesis, studies have predominantly focused on the behaviour and biological significance of adult NSPCs (aNSPCs) in rodents...
June 11, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29901836/chronic-stress-dampens-excitatory-synaptic-gain-in-the-paraventricular-nucleus-of-the-hypothalamus
#18
Eric Salter, Julia Sunstrum, Sara Matovic, Wataru Inoue
KEY POINTS: Glutamatergic synaptic inputs to corticotropin releasing hormone (CRH) secreting neurons in the paraventricular nucleus of the hypothalamus (PVN) are required for stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. These synapses also undergo stress-induced plasticity thereby influencing HPA axis stress adaptation. By using patch clamp electrophysiology, we show that, in adult non-stressed mice, action potentials at these glutamatergic afferents elicit multiquantal transmission to the postsynaptic PVN-CRH neurons (i...
June 14, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29901789/duality-of-function-activation-for-meaningless-nonwords-and-semantic-codes-in-the-same-brain-areas
#19
Samantha R Mattheiss, Hillary Levinson, William W Graves
Studies of the neural substrates of semantic (word meaning) processing have typically focused on semantic manipulations, with less consideration for potential differences in difficulty across conditions. While the idea that particular brain regions can support multiple functions is widely accepted, studies of specific cognitive domains rarely test for co-location with other functions. Here we start with standard univariate analyses comparing words to meaningless nonwords, replicating our recent finding that this contrast can activate task-positive regions for words, and default-mode regions in the putative semantic network for nonwords, pointing to difficulty effects...
July 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29900789/systemic-encephalitozoonosis-due-to-encephalitozoon-cuniculi-strain-iv-in-a-vancouver-island-marmot-marmota-vancouverensis
#20
Ellie Milnes, Pauline Delnatte, Hugh Y Cai, Nicole Nemeth
  A 2-mo-old Vancouver Island marmot ( Marmota vancouverensis), housed at a quarantined breeding facility, presented for acute obtundation and vestibular ataxia. Physical examination revealed poor growth compared with littermates, poor nutritional condition, and mild dehydration. The animal's condition deteriorated over 24 hr, and it was euthanized following the development of generalized seizures. No gross abnormalities were observed upon postmortem evaluation. Histologic evaluation revealed severe, multifocal, granulomatous and lymphoplasmacytic meningoencephalomyelitis and interstitial nephritis, with intralesional, intracytoplasmic spore-filled, parasitophorous vacuoles and segmental, multi-organ, fibrinoid vasculitis (disseminated encephalitozoonosis)...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
keyword
keyword
118389
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"