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COPD lung cancer

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https://www.readbyqxmd.com/read/28076701/reduced-expiratory-flow-rate-among-heavy-smokers-increases-lung-cancer-risk-results-from-the-nlst-acrin-cohort-n-18-714
#1
Raewyn J Hopkins, Fenghai Duan, Caroline Chiles, Erin M Greco, Greg D Gamble, Denise Aberle, Robert P Young
RATIONALE: While epidemiological studies consistently show that chronic obstructive pulmonary disease (COPD) is associated with an increased risk of lung cancer, debate exists as to whether there is a linear relationship between the severity of airflow limitation and lung cancer risk. OBJECTIVES: We examined this in a large prospective study of older heavy smokers from the American College of Radiology Imaging Network sub-cohort of the National Lung Screening Trial (NLST-ACRIN)...
January 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28063900/smoker-extracellular-vesicles-influence-status-of-human-bronchial-epithelial-cells
#2
Amélie Héliot, Yann Landkocz, Françoise Roy Saint-Georges, Pierre Gosset, Sylvain Billet, Pirouz Shirali, Dominique Courcot, Perrine J Martin
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns. Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes...
December 30, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28061470/lung-cancer-and-chronic-obstructive-pulmonary-disease-from-a-clinical-perspective
#3
Jie Dai, Ping Yang, Angela Cox, Gening Jiang
Chronic obstructive pulmonary disease (COPD) and lung cancer are devastating pulmonary diseases that commonly coexist and present a number of clinical challenges. COPD confers a higher risk for lung cancer development, but available chemopreventive measures remain rudimentary. Current studies have shown a marked benefit of cancer screening in the COPD population, although challenges remain, including the common underdiagnosis of COPD. COPD-associated lung cancer presents distinct clinical features. Treatment for lung cancer coexisting with COPD is challenging as COPD may increase postoperative morbidities and decrease survival...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28056271/-disease-burden-attributable-to-household-air-pollution-in-1990-and-2013-in-china
#4
P Yin, Y Cai, J M Liu, Y N Liu, J L Qi, L J Wang, J L You, M G Zhou
Objective: To assess the disease burden attributable to household air pollution in 1990 and 2013 in China. Methods: Based on data from the Global Burden of Disease Study 2013 in China (GBD 2013), we used population attributable fractions (PAF) to analyze the burden of different diseases attributable to solid-fuel household pollution in 2013 in China(not inclnding HongKang, Macao, Taiwan). We compared PAF, mortality, and disability-adjusted life years (DALY) for diseases attributable to solid-fuel household pollution in 31 provinces in mainland China in 1990 and 2013, and stratified the burden by age group...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28055066/association-between-antipsychotic-agents-and-risk-of-acute-respiratory-failure-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Meng-Ting Wang, Chen-Liang Tsai, Chen Wei Lin, Chin-Bin Yeh, Yun-Han Wang, Hui-Lan Lin
Importance: Acute respiratory failure (ARF) is a life-threatening event that has been linked in case reports to antipsychotic use, but this association lacks population-based evidence. Particular attention should be focused on patients with chronic obstructive pulmonary disease (COPD) regarding this drug safety concern because these patients are prone to ARF and are commonly treated with antipsychotics. Objective: To determine whether the use of antipsychotics is associated with an increased risk of ARF in patients with COPD...
January 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28044437/body-mass-index-change-in-gastrointestinal-cancer-and-chronic-obstructive-pulmonary-disease-is-associated-with-dedicator-of-cytokinesis-1
#6
Merry-Lynn Noelle McDonald, Sungho Won, Manuel Mattheisen, Peter J Castaldi, Michael H Cho, Erica Rutten, Megan Hardin, Wai-Ki Yip, Stephen I Rennard, David A Lomas, Emiel F M Wouters, Alvar Agusti, Richard Casaburi, Christoph P Lange, George O'Connor, Craig P Hersh, Edwin K Silverman
BACKGROUND: There have been a number of candidate gene association studies of cancer cachexia-related traits, but no genome-wide association study (GWAS) has been published to date. Cachexia presents in patients with a number of complex traits, including both cancer and COPD. The objective of the current investigation was to search for a shared genetic aetiology for change in body mass index (ΔBMI) among cancer and COPD by using GWAS data in the Framingham Heart Study. METHODS: A linear mixed effects model accounting for age, sex, and change in smoking status was used to calculate ΔBMI in participants over 40 years of age with three consecutive BMI time points (n = 4162)...
January 2, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28043076/bio-sniffer-gas-phase-biosensor-with-secondary-alcohol-dehydrogenase-s-adh-for-determination-of-isopropanol-in-exhaled-air-as-a-potential-volatile-biomarker
#7
Po-Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Exhaled breath analysis has attracted lots of researchers attention in the past decades due to its advantages such as its non-invasive property and the possibility of continuous monitoring. In addition, several volatile organic compounds in breath have been identified as biomarkers for some diseases. Particularly, studies have pointed out that concentration of isopropanol (IPA) in exhaled air might relate with certain illnesses such as liver disease, chronic obstructive pulmonary (COPD), and lung cancer. In this study, a highly sensitive and selective biochemical gas sensor (bio-sniffer) for the breath IPA concentration determination was constructed and optimized...
December 22, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28042952/uncoupling-protein-2-downregulation-by-hypoxia-through-repression-of-peroxisome-proliferator-activated-receptor-%C3%AE-promotes-chemoresistance-of-non-small-cell-lung-cancer
#8
Mingxing Wang, Guoyin Li, Zhiwei Yang, Lei Wang, Lei Zhang, Ting Wang, Yimeng Zhang, Shengli Zhang, Yong Han, Lintao Jia
Hypoxic microenvironment is critically involved in the response of non-small cell lung cancer (NSCLC) to chemotherapy, the mechanisms of which remain largely unknown. Here, we found that NSCLC patients exhibited increased chemotherapeutic resistance when complicated by chronic obstructive pulmonary disease (COPD), a critical cause of chronic hypoxemia. The downregulation of uncoupling protein 2 (UCP2), which is attributed to hypoxia-inducible factor 1 (HIF-1)-mediated suppression of the transcriptional factor peroxisome proliferator-activated receptor γ (PPARγ), was involved in NSCLC chemoresistance, and predicted a poor survival rate of patients receiving routine chemotherapy...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28039288/how-long-do-patients-with-chronic-disease-expect-to-live-a-systematic-review-of-the-literature
#9
Barnaby Hole, Joseph Salem
OBJECTIVE: To systematically identify and summarise the literature on perceived life expectancy among individuals with non-cancer chronic disease. SETTING: Published and grey literature up to and including September 2016 where adults with non-cancer chronic disease were asked to estimate their own life expectancy. PARTICIPANTS: From 6837 screened titles, 9 articles were identified that met prespecified criteria for inclusion. Studies came from the UK, Netherlands and USA...
December 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/28001196/-financial-impact-of-smoking-on-health-systems-in-latin-america-a-study-of-seven-countries-and-extrapolation-to-the-regional-level
#10
Andrés Pichon-Riviere, Ariel Bardach, Federico Augustovski, Andrea Alcaraz, Luz Myriam Reynales-Shigematsu, Márcia Teixeira Pinto, Marianela Castillo-Riquelme, Esperanza Peña Torres, Diana Isabel Osorio, Leandro Huayanay, César Loza Munarriz, Belén Sáenz de Miera-Juárez, Verónica Gallegos-Rivero, Catherine De La Puente, María Del Pilar Navia-Bueno, Joaquín Caporale
Objective: Estimate smoking-attributable direct medical costs in Latin American health systems. Methods: A microsimulation model was used to quantify financial impact of cardiovascular and cerebrovascular disease, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer, and nine other neoplasms. A systematic search for epidemiological data and event costs was carried out. The model was calibrated and validated for Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, and Peru, countries that account for 78% of Latin America's population; the results were then extrapolated to the regional level...
October 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27990285/non-small-cell-lung-cancer-is-characterised-by-a-distinct-inflammatory-signature-in-serum-compared-with-chronic-obstructive-pulmonary-disease
#11
Hanne Astrid Eide, Ann Rita Halvorsen, Vandana Sandhu, Anne Fåne, Janna Berg, Vilde Drageset Haakensen, Elin H Kure, Odd Terje Brustugun, Cecilie Essholt Kiserud, Jon Amund Kyte, Åslaug Helland
Development of lung cancer is closely related to smoking in a majority of patients. Most smokers, however, do not develop lung cancer in spite of a high mutational load accumulating in the lung tissue. Here we investigate whether a cancer-specific footprint can be revealed by investigating circulating inflammatory markers in patients with non-small cell lung cancer (NSCLC) compared with patients with chronic obstructive pulmonary disease (COPD), both cohorts characterised by similar smoking history. Serum concentrations of 57 cytokines and matrix metalloproteinases (MMPs) from 43 patients with advanced NSCLC were evaluated by multiplex immunoassays and compared with serum samples from 35 patients with COPD...
November 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/27986981/-pulmonary-causes-of-chest-pain
#12
B Jany
Chest pain represents one of the most frequent symptoms of pulmonary diseases, in addition to dyspnea and cough. The broad differential diagnostics include the intensely painful but prognostically benign acute pleurisy as well as potentially life-threatening events, such as acute pulmonary embolism or malignant chest diseases. Primary spontaneous pneumothorax is characterized by acute chest pain. Pain associated with a respiratory infection, such as pneumonia rarely poses a difficult diagnostic problem. Painful diseases of the lungs can be differentiated in an initial approach by asking the patient if the pain is related to breathing, which is characteristic of pleuritic chest diseases...
December 16, 2016: Der Internist
https://www.readbyqxmd.com/read/27942415/lung-cancer-a-rare-indication-for-but-frequent-complication-after-lung-transplantation
#13
REVIEW
Dirk Van Raemdonck, Robin Vos, Jonas Yserbyt, Herbert Decaluwe, Paul De Leyn, Geert M Verleden
Lung transplantation is an effective and safe therapy for carefully selected patients suffering from a variety of end-stage pulmonary diseases. Lung cancer negatively affects prognosis, particularly in patients who are no longer candidates for complete resection. Lung transplantation can be considered for carefully selected and well staged lung cancer patients with proven, lung-limited, multifocal, (minimally invasive) adenocarcinoma in situ (AIS) (previously called bronchioloalveolar cell carcinoma) causing respiratory failure...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27940297/increased-levels-of-enzymes-involved-in-local-estradiol-synthesis-in-chronic-obstructive-pulmonary-disease
#14
G F J Konings, N L Reynaert, B Delvoux, F M Verhamme, K R Bracke, G G Brusselle, A Romano, J H J Vernooy
INTRODUCTION: Steroid hormones are involved in lung development, pulmonary inflammation, and lung cancer. Estrogen signaling and exposure may play a role in pulmonary disorders, including COPD. In both genders, estrogens can be generated locally in the lungs and this contributes importantly to the tissue exposure to these steroids. OBJECTIVE: To characterize and assess differences in localization of estrogen receptors and enzymes involved in the local generation of estrogens in COPD...
December 8, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27891773/cigarette-smoke-alters-the-secretome-of-lung-epithelial-cells
#15
Alessandra Mossina, Christina Lukas, Juliane Merl-Pham, Franziska E Uhl, Kathrin Mutze, Andrea Schamberger, Claudia Staab-Weijnitz, Jie Jia, Ali Ö Yildirim, Melanie Königshoff, Stefanie M Hauck, Oliver Eickelberg, Silke Meiners
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease (COPD). Many of its more than 4500 chemicals are highly reactive thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quantitative mass spectrometry to globally assess alterations in the proteome of different compartments of lung epithelial cells upon exposure to cigarette smoke extract. Proteomic profiling of the human alveolar-derived cell line A549 revealed the most pronounced changes within the cellular secretome with preferential downregulation of proteins involved in wound healing and extracellular matrix (ECM) organization...
November 28, 2016: Proteomics
https://www.readbyqxmd.com/read/27891067/are-healthy-smokers-really-healthy
#16
REVIEW
Zijing Zhou, Ping Chen, Hong Peng
Cigarette smoke contains more than 4500 chemicals which have toxic, mutagenic and carcinogenic effects. Strong evidences have shown that current smokers take a significantly higher risk of cardiovascular diseases, chronic obstructive pulmonary disease (COPD) and lung cancer than nonsmokers. However, less attention has been paid to the smoking induced abnormalities in the individuals defined as healthy smokers who are normal with spirometry, radiographic images, routine physical exam and categorized as healthy control group in many researches...
2016: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/27890654/sublobectomy-versus-lobectomy-for-stage-i-non-small-cell-lung-cancer-in-the-elderly
#17
Chen Qiu, Guanghui Wang, Jun Xu, Lixuan Cui, Wei Dong, Yang Ni, Xiao Qu, Jiajun Du
OBJECTIVE: The aim of our study was to compare the operative characteristics and long term survival for elderly patients with stage I non-small cell lung cancer (NSCLC) who underwent sublobectomy versus lobectomy. METHODS: We identified 245 consecutive elderly patients (≥65y) with pathologic stage I NSCLC who underwent lobectomy or sublobectomy at our institution between 2006 and 2012, and assessed the operative characteristics, recurrence, and survival differences between these approaches...
January 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/27887899/association-of-preoperative-right-and-left-ventricular-diastolic-dysfunction-with-postoperative-atrial-fibrillation-in-patients-undergoing-lung-surgery-a-prospective-observational-study
#18
Norikatsu Mita, Masataka Kuroda, Sohtaro Miyoshi, Shigeru Saito
OBJECTIVES: To clarify the relationship between right and left ventricular (RV and LV) diastolic function and postoperative atrial fibrillation (POAF). The early effects of major lung surgery on cardiac function in the intraoperative period during lung surgery were evaluated, using transesophageal echocardiography. DESIGN: Single-center prospective observational study. SETTING: A public hospital. PARTICIPANTS: Patients undergoing elective lobectomy with lymph node dissection for lung cancer (n = 116)...
September 13, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#19
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27885048/trends-in-educational-inequalities-in-premature-mortality-in-belgium-between-the-1990s-and-the-2000s-the-contribution-of-specific-causes-of-deaths
#20
Françoise Renard, Sylvie Gadeyne, Brecht Devleesschauwer, Jean Tafforeau, Patrick Deboosere
BACKGROUND: Reducing socioeconomic inequalities in mortality, a key public health objective may be supported by a careful monitoring and assessment of the contributions of specific causes of death to the global inequality. METHODS: The 1991 and 2001 Belgian censuses were linked with cause-of-death data, each yielding a study population of over 5 million individuals aged 25-64, followed up for 5 years. Age-standardised mortality rates (ASMR) were computed by educational level (EL) and cause...
November 24, 2016: Journal of Epidemiology and Community Health
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