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Invasive thymoma

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https://www.readbyqxmd.com/read/29021446/nephrotic-syndrome-and-a-retroperitoneal-mass-a-case-report-of-a-patient-with-recurrent-invasive-thymoma
#1
Hiroaki Myoga, Tetsu Akimoto, Naoko Mato, Takakiyo Nakaya, Takuya Murakami, Hiromichi Yoshizawa, Saki Nakagawa, Atsushi Miki, Takahiro Masuda, Takahisa Kobayashi, Yuko Ono, Osamu Saito, Yoshihiko Ueda, Shigeaki Muto, Daisuke Nagata
A 68-year-old man was admitted to our hospital to undergo an examination for nephrotic syndrome while concurrently complicated with recurrent thymoma in the parietal pleura and retroperitoneum. He had been diagnosed with invasive thymoma and had undergone thymo-thymectomy seven years previously. Based on the renal biopsy findings, his nephrotic syndrome was ascribed to minimal change disease. He was treated with corticosteroid monotherapy, which resulted in complete remission six months later, despite the fact that the recurrent thymoma remained...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28851660/thymoma-a-clinicopathological-correlation-of-1470-cases
#2
Annikka Weissferdt, Neda Kalhor, Justin A Bishop, Se Jin Jang, Jae Ro, Fredrik Petersson, Bingcheng Wu, Gerald Langman, Hollie Bancroft, Yalan Bi, Yunxiao Meng, Filomena Medeiros, Hans Brunnstrom, Dominic Spagnolo, Siaw Ming Chai, Andrew Laycock, Paul E Wakely, Goran Elmberger, Fernando A Soares, Antonio H Campos, Derya Gumurdulu, Isabel Alvarado-Cabrero, Domenico Coppola, Arlene M Correa, David Rice, Reza J Mehran, Boris Sepesi, Garrett Walsh, Larry Kaiser, Cesar A Moran
We present 1470 surgical resections for thymoma identified in the pathology files of 14 institutions from 11 countries with the purpose to determine and correlate a simplified histological classification of thymoma and pathological staging with clinical outcome. The study population was comprised of 720 men and 750 women between the ages of 12 and 86years (average: 54.8years). Clinically 137 patients (17%) had a history of myasthenia gravis, 31 patients (3.8%) of other autoimmune disease, and 55 (6.8%) patients of another neoplastic process...
August 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28839999/a-comparison-of-three-approaches-for-the-treatment-of-early-stage-thymomas-robot-assisted-thoracic-surgery-video-assisted-thoracic-surgery-and-median-sternotomy
#3
Liqiang Qian, Xiaoke Chen, Jia Huang, Hao Lin, Feng Mao, Xiaojing Zhao, Qingquan Luo, Zhengping Ding
BACKGROUND: This aim of this study was to compare three approaches of extended thymectomy for the treatment of early-stage thymomas, which included robot-assisted thoracic surgery (RATS), video-assisted thoracic surgery (VATS), and median sternotomy (MS) perioperative parameters. METHODS: A retrospective study was conducted on 123 patients with early stage thymomas at Shanghai Chest Hospital who underwent extended thymectomy between February 2009 and August 2014...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838625/-which-surgery-for-mediastinum-tumor-experience-of-the-department-of-thoracic-surgery-of-chu-hassan-ii-of-f%C3%A3-s
#4
S Rabiou, M Lakranbi, T Ghizlane, H Elfatemi, M Serraj, Y Ouadnouni, M Smahi
INTRODUCTION: Tumors of the mediastinum are a heterogeneous group of dysembryoplatic and neoplastic diseases essentially with different prognoses and therapeutic. These tumors develop slowly and remain long asymptomatic in 40-50% of cases. The purpose of our work is to bring the result of surgical management in diagnostic and therapeutic of principal mediastinum tumors framework. PATIENTS AND METHOD: We reviewed retrospectively the records of 68 patients in our training, between January 2009 and December 2013, for tumor of the mediastinum in the diagnostic framework and or therapy...
August 21, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28806823/propensity-score-adjusted-comparison-of-minimally-invasive-versus-open-thymectomy-in-the-management-of-early-stage-thymoma
#5
Ayotunde B Fadayomi, Carlos E Bravo Iniguez, Ritam Chowdhury, Antonio Coppolino, Francine Jacobson, Michael Jaklitsch, Gita N Mody
No abstract text is available yet for this article.
August 14, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28740696/uniportal-video-assisted-thoracoscopic-thymectomy-and-resection-of-a-giant-thymoma-in-a-patient-witness-of-jehova
#6
Diego Gonzalez-Rivas, Ching Feng Wu, Mercedes de la Torre
A rare case of a giant thymoma in a patient witness of Jehova treated by single port thoracoscopic resection is reported. A 78-year-old man with chest pain and mild dyspnea had been previously diagnosed with giant thymoma went to our hospital and asked for second opinion of operation. Computed tomography showed a 12.5 cm × 9.5 cm × 10 cm mass in the anterior mediastinum. Under the request of this patient, he is only willing to receive minimal invasive surgery without blood transfusion. Thirty-six hours after surgical resection, the patient safely discharged from our hospital without complication...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28711822/extended-thymectomy-left-pneumonectomy-pericardiectomy-and-partial-pleurectomy-for-a-large-thymoma-using-only-a-median-sternotomy
#7
Jorge Cruz, André Sena, Catarina Carvalheiro, Ricardo Ferreira
We present a case of a large thymoma with invasion to the hilum of the lung and pleural dissemination. A 58-year-old woman was diagnosed with a type B2 thymoma, with suspected pericardium, pulmonary artery and left lung invasion and pleural metastasis (Masaoka-Koga stage IVb). A radical resection was planned after systemic chemotherapy. Through a median sternotomy, we resected the tumour, and after confirmation of pericardium and left lung invasion, we also performed resection of the pericardium, of the lung and of the pleural metastasis...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28694075/double-seropositive-myasthenia-gravis-with-acetylcholine-receptor-and-low-density-lipoprotein-receptor-related-protein-4-antibodies-associated-with-invasive-thymoma
#8
Hidehiro Ishikawa, Akira Taniguchi, Yuichiro Ii, Osamu Higuchi, Hidenori Matsuo, Shunya Nakane, Masaru Asahi, Atsushi Niwa, Hidekazu Tomimoto
We describe two cases of myasthenia gravis (MG) with double seropositivity for acetylcholine receptor (AChR) and low-density lipoprotein receptor-related protein 4 (LRP4) antibodies (AChR/LRP4-MG) with invasive thymoma. Both cases showed myasthenic weakness, which was restricted to the ocular muscles for >5 months from onset, and then unprovoked severe clinical deterioration supervened with predominant bulbar symptoms. The patients responded adequately to therapeutic intervention. Serum AChR antibody levels at post-intervention were markedly decreased, whereas LRP4 antibodies were almost unchanged in case 1 and slightly decreased in case 2...
June 3, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28647799/a-case-of-atypical-type-a-thymoma-with-vascular-invasion-and-lung-metastasis
#9
Naoya Kawakita, Kazuya Kondo, Hiroaki Toba, Akiko Yoneda, Hiromitsu Takizawa, Akira Tangoku
We present a case of type A thymoma with invasion of the left brachiocephalic vein and lung metastases. An 84-year-old man underwent extended thymectomy combined with left brachiocephalic vein reconstruction and resection of a lung metastasis. Histological examination showed vascular invasion by the tumor. The lung metastasis had high mitotic activity and slight nuclear enlargement, the so-called "atypical" features, but the main part of the primary tumor did not. However, the intravascular portion of the tumor had "atypical" histological features like the lung metastasis...
June 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28645429/coronary-syndrome-as-the-first-manifestation-of-invasive-thymoma
#10
Jesús Piqueras-Flores, Manuel Rayo-Gutiérrez, Isabel Maria de Lara-Simón
No abstract text is available yet for this article.
June 20, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28559972/foxq1-promotes-cancer-metastasis-by-pi3k-akt-signaling-regulation-in-colorectal-carcinoma
#11
Jia Yun Liu, Xiao Yu Wu, Guan Nan Wu, Fu-Kun Liu, Xue-Quan Yao
Colorectal cancer is one of the major health problems, with invade surrounding tissues, and migrate to distant organs being the most critical concern, thus identified metastasis associated hallmarks and more efficacious treatment are urgently needed. It found that forkhead box q1 (FOXQ1) is aberrant expression in variety of human cancers and FOXQ1 is involved in oncogenic pathways. However, the role of FOXQ1 has been unexplored in colorectal cancer metastasis to date. Here, expression of FOXQ1 was higher in colorectal cancer tissue samples and cancer cell lines than in normal colorectal tissue and cell lines...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28521033/lymph-node-metastases-in-thymic-malignancies-a-chinese-alliance-for-research-in-thymomas-retrospective-database-analysis
#12
Zhitao Gu, Yucheng Wei, Jianhua Fu, Lijie Tan, Peng Zhang, Yongtao Han, Chun Chen, Renquan Zhang, Yin Li, Keneng Chen, Hezhong Chen, Yongyu Liu, Youbing Cui, Yun Wang, Liewen Pang, Zhentao Yu, Xinming Zhou, Yangchun Liu, Yi Shen, Wentao Fang
OBJECTIVES: Lymphatic involvement is believed to be relatively rare in thymic epithelial tumours. The incidence and prognostic significance of nodal metastases are still unclear. The goal of this study was to define the incidence and prognostic relevance of nodal metastasis in patients with thymic epithelial tumours, using a nationwide retrospective database of the Chinese Alliance for Research in Thymomas. METHODS: Patients who underwent upfront surgical resection without preoperative therapy were enrolled for the study...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28458302/clinicopathological-features-of-thymoma-with-ring-calcification-case-reports
#13
Takeo Nakada, Tadashi Akiba, Mitsuo Yabe, Keiichiro Tanaka, Masataka Nakano, Masafumi Suzuki, Toshiaki Morikawa
Thymomas with ring calcifications are very rare and quaint style. Herein, we presented our three cases of thymomas with ring calcifications and reviewed totally 10 cases including 7 cases of previous English literatures. The median age was 53 years. Myasthenia gravis was a complication in 40%. The median maximal diameter was 50 mm. They were diagnosed as pathological type B or had type B component. Based on World Health Organization (WHO) classification, 20%, 60%, and 20% cases were stage I, stage II, and stage III, respectively...
May 1, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28454444/anterior-mediastinum-invasion-by-multiple-myeloma-a-case-report
#14
Ying-Hui Xu, Lu-Guo Sun, Chao Sun, Ou Bai, Ting-Ting Liang, Ke-Wei Ma
Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells in the bone marrow (BM) that secretes monoclonal paraproteins in the blood serum and urine. Bone marrow MM cells can invade and damage the functions of other tissues and organs, such as the lungs, spleen, liver, pancreas, kidneys and lymph nodes. However, the invasion of MM cells primarily located in the BM to the anterior mediastinum at the site of the thymus is an extremely rare event. The current study reports the case of a 53-year-old female who presented with MM with involvement of the anterior mediastinum...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28450687/thymoma-with-immunodeficiency-good-syndrome-associated-with-myasthenia-gravis
#15
REVIEW
Shunsuke Takai, Asako Tagawa, Tomoko Ogawa, Hiroyuki Kato, Noriko Saito, Shinya Okada
Good syndrome is a rare condition in which thymoma is associated with hypogammaglobulinemia; it is characterized by repeated respiratory or systemic infections caused by bacteria, viruses, and fungi, as well as with various autoimmune disorders such as pure red cell aplasia. A 65-year-old woman was admitted to our hospital with ptosis and abdominal muscle weakness. Based on the presence of anti-acetylcholine receptor (Ach-R) antibodies, she was diagnosed with myasthenia gravis (MG). At that time, invasive thymoma of Masaoka stage IVa was also detected...
May 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28449480/reconstruction-of-mediastinal-vessels-for-invasive-thymoma-a-retrospective-analysis-of-25-cases
#16
Yifeng Sun, Chang Gu, Jianxin Shi, Wentao Fang, Qingquan Luo, Dingzhong Hu, Shijie Fu, Xufeng Pan, Yong Chen, Yu Yang, Haitang Yang, Heng Zhao, Haiquan Chen
BACKGROUND: Discuss an appropriate strategy for treatment of invasive thymoma invading adjacent great vessels. METHODS: A retrospective study on 25 patients with invasive thymoma invading neighboring great vessels was performed. The corresponding data including clinical presentation, operation procedure, adjuvant radio-chemotherapy and follow-up were reviewed. RESULTS: Twenty of 25 (80%) patients with invasive thymoma underwent complete resection of the tumor along with vessel reconstruction...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28438465/isaacs-syndrome-with-caspr2-antibody-a-series-of-three-cases
#17
Jie Song, Sisi Jing, Chao Quan, Jun Lu, Xiangyang Qiao, Kai Qiao, Jiahong Lu, Jianying Xi, Chongbo Zhao
Isaacs syndrome is a form of peripheral nerve hyperexcitability, characterized by spontaneous muscle twitching and stiffness. Some patients are reported to be positive for CASPR2 antibody that may be one of the pathogenic autoantibodies in Isaacs syndrome. We reported a series of three patients with Isaacs syndrome, including their clinical features, electrophysiologic findings, laboratory parameters and therapeutic responses. All the three patients were positive for CASPR2 antibodies examined on transfected human embryonic kidney 293 cells by indirect immunofluorescence method...
July 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28431716/invasive-medullary-type-a-thymoma-with-recurrent-distant-metastases
#18
Maria Cecilia Mengoli, Lucia Longo, Susanna Varini, Giulio Rossi, Filippo Lococo
Thymomas are rare epithelial mediastinal tumors showing a certain propensity for local and intrathoracic recurrences. Otherwise, extrathoracic metastases are very rarely reported and are usually associated with type B thymomas or thymic carcinomas. We present a challenging patient with an invasive (Masaoka-Koga stage IIb) medullary type A thymoma with recurrent extrathoracic metastases (pulmonary and vertebral localizations occurring 2 and 7 years after the initial radical thymectomy, respectively). Despite type A thymoma being considered a low-grade malignancy with a scarce propensity to recurrence, the present case should alert clinicians to the possibility of bone metastasis...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28416933/thymectomy-in-myasthenia-gravis
#19
REVIEW
Yener Aydin, Ali Bilal Ulas, Vahit Mutlu, Abdurrahim Colak, Atilla Eroglu
In recent years, thymectomy has become a widespread procedure in the treatment of myasthenia gravis (MG). Likelihood of remission was highest in preoperative mild disease classification (Osserman classification 1, 2A). In absence of thymoma or hyperplasia, there was no relationship between age and gender in remission with thymectomy. In MG treatment, randomized trials that compare conservative treatment with thymectomy have started, recently. As with non-randomized trials, remission with thymectomy in MG treatment was better than conservative treatment with only medication...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28381664/therapeutic-potential-of-docetaxel-plus-cisplatin-chemotherapy-for-myasthenia-gravis-patients-with-metastatic-thymoma
#20
Guoyan Qi, Peng Liu, Huimin Dong, Shanshan Gu, Hongxia Yang, Yinping Xue
The prognosis of myasthenia gravis (MG) in association with invasive or metastatic thymoma is usually worse, and therapeutic options are quite limited. Here, we retrospectively reported the therapeutic effect of docetaxel plus cisplatin (docetaxel/cisplatin) chemotherapy in 7 MG patients with metastatic thymoma. Previously, all patients underwent thymectomy at the first onset of thymoma. After the metastasis of thymoma, none of the patients received thymectomy due to unresectable conditions after surgeon's evaluation for great risk of myasthenic crisis (n = 5) or patients' refusal (n = 2)...
April 2017: Tohoku Journal of Experimental Medicine
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