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Invasive thymoma

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https://www.readbyqxmd.com/read/27908939/l-shaped-mini-sternotomy-combined-with-videoscopic-approach-for-thymoma-with-invasion-of-major-veins
#1
Atsushi Suga, Shunsuke Yamada, Haruka Takeichi, Yusuke Nakamura, Masayuki Iwazaki
It might be possible to remove thymic tumors with minimal invasion of the left brachiocephalic vein (BCV) using an advanced videoscopic technique; simple resection of this vessel can be achieved via such an approach. However, tumor invasion of the superior vena cava or right  BCV requires angioplasty or reconstruction, both of which are difficult to perform in videoscopic procedures. We report a case of invasive thymoma with localized invasion of the great vessels at the junction of the left BCV and superior vena cava...
December 1, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27876891/genetic-variations-in-the-pi3k-pten-akt-mtor-pathway-are-associated-with-distant-metastasis-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiation-therapy
#2
Qiaojuan Guo, Tianzhu Lu, Yan Chen, Ying Su, Yuhong Zheng, Zeng Chen, Chao Chen, Shaojun Lin, Jianji Pan, Xianglin Yuan
Distant metastasis is the primary failure pattern of nasopharyngeal carcinoma(NPC) in intensity-modulated radiation therapy(IMRT) era. This study was conducted to find the impact of genetic variations in the phosphatidylinositol 3-kinase(PI3K)/phosphatase and tensin homologue(PTEN)/v-akt murine thymoma viral oncogene homologue(AKT)/mammalian target of rapamycin(mTOR) pathway on the risk of distant metastasis in NPC. We genotyped 16 single-nucleotide polymorphisms(SNPs) in five core genes in this pathway from 496 patients treated by IMRT with or without chemotherapy...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872781/two-invasive-thymomas-incidentally-found-during-coronary-artery-bypass-graft-surgery
#3
Navid Omidifar, Maral Mokhtari, Mansoureh Shokripour
Thymoma, the most common neoplasm of the anterior mediastinum, is a rare tumor of thymic epithelium that can be locally invasive. We reported 2 cases of invasive thymoma incidentally found during routine coronary artery bypass graft (CABG) surgery at Faghihee Hospital of Shiraz University of Medical Sciences of Iran in a period of about 6 months. The 2 patients were male and above 60 years old. They had no clinical symptoms and radiological evidence of mediastinal mass before detection of the tumor during operation...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27847087/thymoma-potential-for-life-threatening-cardiac-invasion
#4
Eshan L Senanayake, Heyman Luckraz
No abstract text is available yet for this article.
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27816689/minimally-invasive-resection-of-synchronous-triple-primary-tumors-of-the-esophagus-lung-and-thymus-a-case-report
#5
Xiao Song, Haibo Shen, Jie Li, Fengmin Wang
INTRODUCTION: Reports of synchronous multiple primary tumors are very rare. We report a case of synchronous esophagus and lung cancer combined with thymoma treated with a minimally invasive approach. PRESENTATION OF CASE: In a 63-year-old patient, cT2 esophageal squamous cell carcinoma was found. Chest computed tomography revealed a lesion in the right upper lobe combined with an antero-superior mediastinal mass. She was treated with one-stage bilateral video-assisted thoracoscopic+laparoscopic esophagectomy with lymph node dissection and lobectomy with complete lymphadenectomy followed by thymomectomy and demonstrated a favorable response at early follow-up, without severe adverse surgical complications and evidence of local recurrence or distant metastasis...
October 23, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27797848/invasive-thymoma-presenting-as-classic-superior-vena-cava-syndrome-a-case-of-venous-spread-metastasis
#6
Prasan Kumar Panda, Naveet Wig, Sanjeev Kumar, Sudheer Arava
The approach to an intrinsic cause of superior vena cava syndrome (SVCS) is usually difficult but rewarding. We report a case of a middle-aged man who presented with progressive oedema of the upper half of the body, dyspnoea, cough and weight loss for a 1-year duration. He was a non-smoker without prior hospitalisation. Chest radiography showed right-sided pleural effusion with an apparent normal superior mediastinum. Contrast-enhanced CT of the chest revealed a right atrial mass extending and completely obliterating to superior vena cava...
October 26, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27770408/a-case-of-atypical-type-a-thymoma-variant
#7
Masaki Hashimoto, Shigeki Shimizu, Teruhisa Takuwa, Yoshitane Tsukamoto, Tohru Tsujimura, Seiki Hasegawa
BACKGROUND: An atypical type A thymoma variant was newly added to the WHO classification of type A thymoma family in 2015. CASE PRESENTATION: A 72-year-old female was present a large round mass in the anterior mediastinum. The radiological examination led to a preoperative diagnosis of non-invasive thymoma. Tumor resection was undertaken via median sternotomy. Complete removal of the mediastinal tumor was achieved. Pathological examination revealed that the tumor cells were spindle- and oval-shaped with atypia...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27747012/prognostic-value-of-immunohistochemical-markers-in-malignant-thymic-epithelial-tumors
#8
Priska Leisibach, Didier Schneiter, Alex Soltermann, Yoshi Yamada, Walter Weder, Wolfgang Jungraithmayr
BACKGROUND: Thymic epithelial tumors (TET) are rare neoplasms with inconsistent treatment strategies. When researching for molecular pathways to find new therapies, the correlation between specific molecular markers and outcome has only rarely been investigated. The aim of this study was to investigate the correlation between survival, metastatic potential and invasiveness of aggressive subtypes of TET and immunohistochemical markers. METHODS: Overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) and metastasis-free survival (MFS) of patients with WHO type B2/B3 mixed type thymoma (MT), thymoma type B3 (B3) and thymic carcinoma (TC), undergoing surgery [1998-2013] were determined...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27631952/robotic-resection-of-3-cm-and-larger-thymomas-is-associated-with-low-perioperative-morbidity-and-mortality
#9
Candice L Wilshire, Eric Vallières, Dale Shultz, Ralph W Aye, Alexander S Farivar, Brian E Louie
OBJECTIVE: The approach to thymoma resection has usually been determined by tumor size, although established guidelines do not exist. Minimally invasive approaches have been limited to tumors smaller than 5 cm, although 3 cm has been the suggested cutoff for performing an adequate oncologic procedure. No study has compared the perioperative outcomes of patients with 3 cm or larger tumors resected robotically versus sternotomy. METHODS: We reviewed patients who underwent resection of 3 cm or larger thymomas from 2004 to 2014...
September 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27629968/postoperative-recurrence-of-invasive-thymoma-with-cold-agglutinin-disease-and-autoimmune-hemolytic-anemia
#10
Taro Yoneda, Hayato Koba, Kota Tanimura, Naohiko Ogawa, Satoshi Watanabe, Johsuke Hara, Miki Abo, Takashi Sone, Hideharu Kimura, Kazuo Kasahara
A 50-year-old man presented to our hospital in 1995. Invasive thymoma was diagnosed and extended thymectomy and left upper lobe partial resection were performed. In 2013, he complained of dyspnea. Chest computed tomography showed postoperative recurrence of invasive thymoma. Several chemotherapies were administered. Severe anemia and an increase in the total bilirubin level were observed with chemotherapies. In additional, an examination showed that the direct Coombs test was positive. Cold agglutinin was also high...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27627742/robotics-in-pulmonology-and-thoracic-surgery-what-why-and-when
#11
Konstantinos Gioutsos, Gregor J Kocher, Ralph A Schmid
INTRODUCTION: Robot-assisted surgery emerged and evolved in order to increase the surgical precision and due to the need to overcome the drawbacks of conventional minimally invasive surgery. In thoracic surgery the first reported use of a robotic device was in a series of 12 patients with different lung pathologies with the assistance of the DaVinci Robotic Surgical System in 2002. The DaVinci system has been used for various procedures in the field of thoracic surgery since then. While its advantages for the resection of early stage thymoma have been well documented, its role in the treatment of lung cancer and other pathologies is still under investigation...
December 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27566187/determinants-of-complete-resection-of-thymoma-by-minimally-invasive-and-open-thymectomy-analysis-of-an-international-registry
#12
Bryan M Burt, Xiaopan Yao, Joseph Shrager, Alberto Antonicelli, Sukhmani Padda, Jonathan Reiss, Heather Wakelee, Stacey Su, James Huang, Walter Scott
INTRODUCTION: Minimally invasive thymectomy (MIT) is a surgical approach to thymectomy that has more favorable short-term outcomes for myasthenia gravis than open thymectomy (OT). The oncologic outcomes of MIT performed for thymoma have not been rigorously evaluated. We analyzed determinants of complete (R0) resection among patients undergoing MIT and OT in a large international database. METHODS: The retrospective database of the International Thymic Malignancy Interest Group was queried...
August 24, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27542926/bone-metastasis-of-malignant-thymomas-associated-with-peripheral-t-cell-lymphocytosis
#13
Luo Zhao, Xi Zhou, Zheng Li, Yong Liu
BACKGROUND: Malignant thymomas are rarely associated with bone metastasis and T-cell lymphocytosis. CASE PRESENTATION: A 47-year-old female patient was admitted to our hospital for ptosis. A diagnosis of malignant thymoma was made based on the thymectomy and pathological result. Peripheral T-cell lymphocytosis and bone metastasis were found later. T-cell lymphocytosis was relived after surgical and radiation therapy to the metastasis. CONCLUSION: Peripheral T-cell lymphocytosis is a rare paraneoplastic phenomenon associated with thymomas...
August 19, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27451826/-cryptic-mediastinal-tuberculosis-with-myasthenia-thymoma-complex
#14
George Jose Valooran, Shiv Kumar Nair, Krishnan Chandrasekharan, Sunitha Thomas, Joejo John
Mediastinal tuberculosis, although common in endemic areas, is rare in association with myasthenia-thymoma complex. Immunosuppressive therapy for myasthenia with thymoma might increase the susceptibility for mediastinal tuberculosis. Previous reports suggest aggravation of myasthenic symptoms with this association. This rare combination of pathologies adds to the diagnostic dilemma of the surgeon. Further research is warranted in the management aspects of this combination as regards to the timing of radiotherapy, weaning of immunosuppression and anti-tubercular therapy after maximal thymectomy...
April 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27371363/thymomas-with-extensive-clear-cell-component-%C3%A2-a-clinicopathologic-and-immunohistochemical-study-of-nine-cases
#15
Annikka Weissferdt, Neda Kalhor, Cesar A Moran
OBJECTIVES: Nine cases of thymomas with an extensive clear cell component are presented. METHODS: The patients were six men and three women aged between 45 and 62 years (mean, 52 years). Presenting symptoms included shortness of breath, chest pain, and cough. Diagnostic imaging revealed anterior mediastinal masses in all patients, and all underwent thymectomy. RESULTS: Grossly, the tumors varied from 3 to 9 cm in the greatest dimension. Four cases were invasive and five encapsulated...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27231905/role-of-mitochondrial-dna-copy-number-alteration-in-human-renal-cell-carcinoma
#16
Chen-Sung Lin, Hui-Ting Lee, Ming-Huei Lee, Siao-Cian Pan, Chen-Yeh Ke, Allen Wen-Hsiang Chiu, Yau-Huei Wei
We investigated the role of mitochondrial DNA (mtDNA) copy number alteration in human renal cell carcinoma (RCC). The mtDNA copy numbers of paired cancer and non-cancer parts from five resected RCC kidneys after radical nephrectomy were determined by quantitative polymerase chain reaction (Q-PCR). An RCC cell line, 786-O, was infected by lentiviral particles to knock down mitochondrial transcriptional factor A (TFAM). Null target (NT) and TFAM-knockdown (TFAM-KD) represented the control and knockdown 786-O clones, respectively...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27206780/bilateral-thoracoscopic-extended-thymectomy-versus-sternotomy
#17
Alfonso Fiorelli, Antonio Mazzella, Roberto Cascone, Francesco Paolo Caronia, Ettore Arrigo, Mario Santini
BACKGROUND: Complete open surgical resection is the standard treatment for thymoma and myasthenia gravis. We evaluated the feasibility of bilateral video-assisted thoracoscopic extended thymectomy, and compared it to surgery via sternotomy. METHODS: From 2011 to 2014, 43 patients undergoing thymectomy were divided into 2 groups: 23 underwent video-assisted thoracoscopic extended thymectomy, and 20 had thymectomy via sternotomy. The primary outcomes were postoperative pain score (visual analog scale) at 6, 12, 24, 48, and 72 h, and 1-month postoperatively, and morphine consumption in the first 48 h...
July 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/27177265/impact-of-surgical-evaluation-of-additional-cine-magnetic-resonance-imaging-for-advanced-thymoma-with-infiltration-of-adjacent-structures-the-thoracic-surgeon-s-view
#18
Michael Ried, Stefanie Hnevkovsky, Reiner Neu, Marietta von Süßkind-Schwendi, Andrea Götz, Okka W Hamer, Berthold Schalke, Hans-Stefan Hofmann
Background Preoperative radiological assessment is important for clarification of surgical operability for advanced thymic tumors. Objective was to determine the feasibility of magnetic resonance imaging (MRI) with cine sequences for evaluation of cardiovascular tumor invasion. Patients and Methods This prospective study included patients with advanced thymoma, who underwent surgical resection. All patients received preoperative computed tomography (CT) scan and cine MRI. Results Tumor infiltration was surgically confirmed in the pericardium (n = 12), myocardium (n = 1), superior caval vein (SCV; n = 3), and aorta (n = 2)...
May 13, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27144380/histologic-and-immunohistochemical-characterization-of-thymic-epithelial-tumours-in-the-dog
#19
K E Burgess, C J DeRegis, F S Brown, J H Keating
Thymic epithelial tumour (TET) histologic subclassification has not been well described in the veterinary literature as it has in humans. The objective of this study was to identify and describe TET subtypes in dogs and to determine the utility of immunohistochemistry (IHC) in differentiating these subtypes. Samples were reviewed and classified according to a modified World Health Organization (WHO) criteria for human tumours of thymic origin. Signallment, presenting signs, treatment and survival data was collected from medical records...
June 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/27114841/comparison-of-the-masaoka-koga-staging-and-the-international-association-for-the-study-of-lung-cancer-the-international-thymic-malignancies-interest-group-proposal-for-the-tnm-staging-systems-based-on-the-chinese-alliance-for-research-in-thymomas-retrospective
#20
Guanghui Liang, Zhitao Gu, Yin Li, Jianhua Fu, Yi Shen, Yucheng Wei, Lijie Tan, Peng Zhang, Yongtao Han, Chun Chen, Renquan Zhang, Keneng Chen, Hezhong Chen, Yongyu Liu, Youbing Cui, Yun Wang, Liewen Pang, Zhentao Yu, Xinming Zhou, Yangchun Liu, Yuan Liu, Wentao Fang
BACKGROUND: To compare the predictive effect of the Masaoka-Koga staging system and the International Association for the Study of Lung Cancer (IASLC)/the International Thymic Malignancies Interest Group (ITMIG) proposal for the new TNM staging on prognosis of thymic malignancies using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: From 1992 to 2012, 2,370 patients in ChART database were retrospectively reviewed. Of these, 1,198 patients with complete information on TNM stage, Masaoka-Koga stage, and survival were used for analysis...
April 2016: Journal of Thoracic Disease
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