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Cooperative extension

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https://www.readbyqxmd.com/read/28343220/hemorrhagic-transformations-after-thrombectomy-risk-factors-and-clinical-relevance
#1
Johannes Kaesmacher, Mirjam Kaesmacher, Christian Maegerlein, Claus Zimmer, Alexandra S Gersing, Silke Wunderlich, Benjamin Friedrich, Tobias Boeckh-Behrens, Justus F Kleine
BACKGROUND: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke, potentially associated with clinical deterioration. We attempted to identify risk factors and evaluated clinical relevance of minor and major HTs following endovascular thrombectomy (ET) in isolated middle cerebral artery (MCA) occlusions. METHODS: This is a retrospective single-center analysis of 409 patients with isolated MCA occlusion treated with ET. Patients' and procedural characteristics, severity of HT according to the European Cooperative Acute Stroke Study criteria, and clinical outcomes were analyzed...
March 25, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28335494/cooperative-opportunistic-pressure-based-routing-for-underwater-wireless-sensor-networks
#2
Nadeem Javaid, Muhammad, Arshad Sher, Wadood Abdul, Iftikhar Azim Niaz, Ahmad Almogren, Atif Alamri
In this paper, three opportunistic pressure based routing techniques for underwater wireless sensor networks (UWSNs) are proposed. The first one is the cooperative opportunistic pressure based routing protocol (Co-Hydrocast), second technique is the improved Hydrocast (improved-Hydrocast), and third one is the cooperative improved Hydrocast (Co-improved Hydrocast). In order to minimize lengthy routing paths between the source and the destination and to avoid void holes at the sparse networks, sensor nodes are deployed at different strategic locations...
March 19, 2017: Sensors
https://www.readbyqxmd.com/read/28327517/combined-pre-distortion-and-censoring-for-bandwidth-efficient-and-energy-efficient-fusion-of-spectrum-sensing-information
#3
Guilherme Pedro Aquino, Dayan Adionel Guimarães, Luciano Leonel Mendes, Tales Cleber Pimenta
This paper describes a novel scheme for the fusion of spectrum sensing information in cooperative spectrum sensing for cognitive radio applications. The scheme combines a spectrum-efficient, pre-distortion-based fusion strategy with an energy-efficient censoring-based fusion strategy to achieve the combined effect of reduction in bandwidth and power consumption during the transmissions of the local decisions to the fusion center. Expressions for computing the key performance metrics of the spectrum sensing of the proposed scheme are derived and validated by means of computer simulations...
March 22, 2017: Sensors
https://www.readbyqxmd.com/read/28322168/pediatric-off-label-and-unlicensed-drug-use-and-its-implications
#4
Rajeshwari Gore, Preeta Kaur Chugh, Chakra Dhar Tripathi, Yangshen Lhamo, Sandhya Gautam
BACKGROUND: Worldwide, in the absence of standard pediatric prescribing information, clinicians often use medicines in children in a dosage form or for an indication that has not been approved for use. Inadequate clinical trials increase exposure to drugs that lack safety-efficacy data in pediatric population. Hence, off-label and unlicensed drug use must be regarded as a patient safety-issue that is known to be associated with increased risks of adverse drug reactions apart from under- or over-dosing due to lack of pharmacokinetic data...
March 17, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28316511/binary-classifier-calibration-using-an-ensemble-of-near-isotonic-regression-models
#5
Mahdi Pakdaman Naeini, Gregory F Cooper
Learning accurate probabilistic models from data is crucial in many practical tasks in data mining. In this paper we present a new non-parametric calibration method called ensemble of near isotonic regression (ENIR). The method can be considered as an extension of BBQ [20], a recently proposed calibration method, as well as the commonly used calibration method based on isotonic regression (IsoRegC) [27]. ENIR is designed to address the key limitation of IsoRegC which is the monotonicity assumption of the predictions...
December 2016: Proceedings
https://www.readbyqxmd.com/read/28303552/european-radiographers-challenges-from-mammography-education-and-clinical-practice-an-integrative-review
#6
Eija Metsälä, Nicole Richli Meystre, José Pires Jorge, Anja Henner, Tiina Kukkes, Cláudia Sá Dos Reis
OBJECTIVES: This study aims to identify European radiographers' challenges in clinical performance in mammography and the main areas of mammography that require more and better training. METHODS: An extensive search was performed to identify relevant studies focused on clinical practice, education and training in mammography published between January 2010 and December 2015 in the English language. The data were analysed by using deductive thematic analysis. RESULTS: A total of 27 full text articles were read, evaluating their quality...
March 16, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28301177/trust-trolleys-and-social-dilemmas-a-replication-study
#7
Dries H Bostyn, Arne Roets
The present manuscript addresses how perceived trustworthiness of cooperative partners in a social dilemma context is influenced by the moral judgments those partners make on Trolley-type moral dilemmas; an issue recently investigated by Everett, Pizarro, and Crockett (2016). The present research comprises 2 studies that were conducted independently, simultaneously with, and incognizant of the Everett studies. Whereas the present studies aimed at investigating the same research hypothesis, a different and more elaborate methodology was used, as such providing a conceptual replication opportunity and extension to the Everett et al...
March 16, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28297929/flexible-dynamics-of-two-quorum-sensing-coupled-repressilators
#8
Edward H Hellen, Evgeny Volkov
Genetic oscillators play important roles in cell life regulation. The regulatory efficiency usually depends strongly on the emergence of stable collective dynamic modes, which requires designing the interactions between genetic networks. We investigate the dynamics of two identical synthetic genetic repressilators coupled by an additional plasmid which implements quorum sensing (QS) in each network thereby supporting global coupling. In a basic genetic ring oscillator network in which three genes inhibit each other in unidirectional manner, QS stimulates the transcriptional activity of chosen genes providing for competition between inhibitory and stimulatory activities localized in those genes...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28293204/what-are-the-ingredients-for-an-inequity-paradigm-manipulating-the-experimenter-s-involvement-in-an-inequity-task-with-dogs
#9
Désirée Brucks, Sarah Marshall-Pescini, Jennifer L Essler, Jim McGetrick, Ludwig Huber, Friederike Range
Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28273164/mi-sim-a-matlab-package-for-the-numerical-analysis-of-microbial-ecological-interactions
#10
Matthew J Wade, Jordan Oakley, Sophie Harbisher, Nicholas G Parker, Jan Dolfing
Food-webs and other classes of ecological network motifs, are a means of describing feeding relationships between consumers and producers in an ecosystem. They have application across scales where they differ only in the underlying characteristics of the organisms and substrates describing the system. Mathematical modelling, using mechanistic approaches to describe the dynamic behaviour and properties of the system through sets of ordinary differential equations, has been used extensively in ecology. Models allow simulation of the dynamics of the various motifs and their numerical analysis provides a greater understanding of the interplay between the system components and their intrinsic properties...
2017: PloS One
https://www.readbyqxmd.com/read/28269377/routing-over-multi-hop-fading-wireless-body-area-networks-with-reliability-considerations
#11
Hussein Moosavi, Francis Minhthang Bui
Optimal reliable routing is studied in the context of fading wireless body area networks (WBANs). A non-cooperative game is proposed to model and analyze the strategic interactions among body-worn health-care devices when each seeks to find the most reliable path to the hub. A distributed algorithm based on the proposed game is provided and proved to converge to a multi-hop Pareto-dominant Nash topology. The game-theoretic framework is evaluated through numerical simulations in conditions approximating actual deployment of a moving ultra wideband WBAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28264597/report-of-the-6th-international-workshop-on-pet-in-lymphoma
#12
Cristina Nanni, Anne Ségolène Cottereau, Egesta Lopci, Caroline Bodet-Milin, Monica Coronado, Barbara Pro, Wong Seog Kim, Judith Trotman, Sally Barrington, Ulrich Duhrsen, Thierry Vander Borght, Elena Zamagni, Françoise Kraeber-Bodéré, Christina Messiou, Alain Rahmouni, Irène Buvat, Marc Andre, Mark Hertzberg, Wim Oyen, Olivier Casasnovas, Stefano Luminari, Laurent Garderet, Françoise Montravers, Carsten Kobe, Regine Kluge, Annibale Versari, Emanuele Zucca, Philippe Moreau, Bruce Cheson, Corinne Haioun, Andrea Gallamini, Michel Meignan
Two hundred and ten nuclear medicine physicians, radiologists, and hematologists from 26 countries attended the 6th International Workshop on Positron Emission Tomography (PET) in Lymphoma and Myeloma held in Menton, France, in September 2016. The meeting was under the auspices of the European Lymphoma Institute (ELI), the European Association of Nuclear Medicine (EANM) the Lymphoma Study Association (LYSA), the Italian Foundation on Lymphoma (FIL) and the Carnot Institute for Lymphoma (CALYM). Forty scientific posters were presented...
March 7, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28262371/-cooperation-according-to-french-law-hospital-patients-health-and-territories-pharmacists-involvement-in-aquitaine-region
#13
M d'Elbée, M Baumevieille, C Dumartin
BACKGROUND: In 2009, the French Act "Hospital, Patients, Health and Territories" (loi "Hôpital, Patients, Santé et Territoires") reorganized the outpatient care pathway and defined missions aimed at improving cooperation between pharmaceutical and medical professionals. Five years later, we conducted a survey among community pharmacists in order to assess the appropriation of these missions and the way cooperation was implemented. We also aimed to investigate factors that could hamper or ease the development of these activities in order to identify actions needed to improve pharmacists' involvement...
March 2, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28258234/polishing-the-tarnished-silver-bullet-the-quest-for-new-antibiotics
#14
REVIEW
Mark A T Blaskovich, Mark S Butler, Matthew A Cooper
We are facing a potential catastrophe of untreatable bacterial infections, driven by the inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of pharmaceutical and biotech companies to deliver new therapeutic options. While global recognition of the problem is finally apparent, solutions are still a long way from being implemented. In addition to drug stewardship programmes and better diagnostics, new antibiotics are desperately needed. The question remains as to how to achieve this goal...
February 28, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28256236/optimal-compartmentalization-strategies-for-metabolic-microcompartments
#15
Florian Hinzpeter, Ulrich Gerland, Filipe Tostevin
Intracellular compartmentalization of cooperating enzymes is a strategy that is frequently used by cells. Segregation of enzymes that catalyze sequential reactions can alleviate challenges such as toxic pathway intermediates, competing metabolic reactions, and slow reaction rates. Inspired by nature, synthetic biologists also seek to encapsulate engineered metabolic pathways within vesicles or proteinaceous shells to enhance the yield of industrially and pharmaceutically useful products. Although enzymatic compartments have been extensively studied experimentally, a quantitative understanding of the underlying design principles is still lacking...
February 28, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28251354/fascin-phosphorylation-sites-combine-to-regulate-esophageal-squamous-cancer-cell-behavior
#16
Fa-Min Zeng, Xiao-Ning Wang, Hong-Shun Shi, Jian-Jun Xie, Ze-Peng Du, Lian-Di Liao, Ping-Juan Nie, Li-Yan Xu, En-Min Li
Filopodia are dynamic membrane extensions generated by F-actin bundling and are involved in cancer cell migration, invasion and metastasis. Fascin is the crucial actin-bundling protein in filopodia, with phosphorylation at fascin serine 39 being well characterized to regulate fascin-mediated actin bundling in filopodia. However, increasing evidence indicates that fascin is phosphorylated at a number of sites. Whether phosphorylation at other sites also regulates fascin function is unknown. In this study, we show that four potential phosphorylation sites in fascin, specifically tyrosine 23, serine 38, serine 39 and serine 274, regulate cell behavior and filopodia formation in esophageal squamous cancer cells...
March 1, 2017: Amino Acids
https://www.readbyqxmd.com/read/28246971/bilateral-synergy-as-an-index-of-force-coordination-in-chronic-stroke
#17
Nyeonju Kang, James H Cauraugh
Dysfunction in bilateral coordination post-stroke is responsible for impaired bilateral movements. This study examined bilateral synergies using the uncontrolled manifold (UCM) approach while individuals in a chronic stage after stroke executed bilateral isometric force control at three submaximal force levels. Nine patients with stroke and nine age-matched healthy controls performed 24 trials of wrist and fingers extension at 5, 25, and 50% of MVC. The UCM findings revealed: (a) decreased bilateral synergies in patients with stroke as compared to controls at 50% of MVC and (b) reduced good variability and increased bad variability components in patients with stroke at 50% of MVC...
February 28, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28228472/unconventional-recombination-in-the-mating-type-locus-of-heterothallic-apple-canker-pathogen-valsa-mali
#18
Zhiyuan Yin, Xiwang Ke, Zhengpeng Li, Jiliang Chen, Xiaoning Gao, Lili Huang
Sexual reproduction in filamentous ascomycetes is controlled by mating type (MAT) locus, including two idiomorphs MAT1-1 and MAT1-2 Understanding the MAT locus can provide clues for unveiling the sexual development and virulence factors for fungal pathogens. The genus Valsa (Sordariomycetes, Diaporthales) contains many tree pathogens responsible for destructive canker diseases. Sexual stage of these ascomycetes is occasionally observed in nature and no MAT locus has been reported up till now. Thus, we identified the MAT locus of apple canker pathogen V...
February 21, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28227620/routing-over-multi-hop-fading-wireless-body-area-networks-with-reliability-considerations
#19
Hussein Moosavi, Francis Minhthang Bui, Hussein Moosavi, Francis Minhthang Bui, Francis Minhthang Bui, Hussein Moosavi
Optimal reliable routing is studied in the context of fading wireless body area networks (WBANs). A non-cooperative game is proposed to model and analyze the strategic interactions among body-worn health-care devices when each seeks to find the most reliable path to the hub. A distributed algorithm based on the proposed game is provided and proved to converge to a multi-hop Pareto-dominant Nash topology. The game-theoretic framework is evaluated through numerical simulations in conditions approximating actual deployment of a moving ultra wideband WBAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28208593/context-sensing-system-analysis-for-privacy-preservation-based-on-game-theory
#20
Shengling Wang, Luyun Li, Weiman Sun, Junqi Guo, Rongfang Bie, Kai Lin
In a context sensing system in which a sensor-equipped mobile phone runs an unreliable context-aware application, the application can infer the user's contexts, based on which it provides personalized services. However, the application may sell the user's contexts to some malicious adversaries to earn extra profits, which will hinder its widespread use. In the real world, the actions of the user, the application and the adversary in the context sensing system affect each other, so that their payoffs are constrained mutually...
February 10, 2017: Sensors
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