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Cooperative extension

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https://www.readbyqxmd.com/read/28807641/a-novel-partnership-disrupts-the-norm-in-early-childhood-education-and-pediatric-health-care
#1
EDITORIAL
M Denise Dowd, John D Lantos
Children living in poverty in the United States in 2016 face a devastating combination of psychological problems. Their neighborhoods are often violent. They have no place to get healthy food. It is not safe to play outside, even on playgrounds. The children who grow up in this environment, not surprisingly, have many adverse childhood experiences (ACEs). ACEs cause toxic stress. Toxic stress leads to long-term physical and psychological problems. For many pediatricians, children's hospitals, civic leaders, and public health officials, it is difficult to know how to intervene...
August 11, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28806072/modeling-of-the-passive-permeation-of-mercury-and-methylmercury-complexes-through-a-bacterial-cytoplasmic-membrane
#2
Jing Zhou, Micholas Dean Smith, Sarah J Cooper, Xiaolin Cheng, Jeremy C Smith, Jerry M Parks
Cellular uptake and export are important steps in the biotransformation of mercury (Hg) by microorganisms. However, the mechanisms of transport across biological membranes remain unclear. Membrane-bound transporters are known to be relevant, but passive permeation may also be involved. Inorganic Hg(II) and methylmercury ([CH3Hg]+) are commonly complexed with thiolate ligands. Here, we have performed extensive molecular dynamics simulations of the passive permeation of Hg(II) and [CH3Hg]+ complexes with thiolate ligands through a model bacterial cytoplasmic membrane...
August 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28800879/the-association-between-fruit-and-vegetable-consumption-and-fruit-and-vegetable-stage-of-change-in-underserved-communities-engaging-with-cooperative-extension-services
#3
Shannon M Robson, Elizabeth Orsega-Smith, Katie Greenawalt, P M Peterson
OBJECTIVE: To compare differences in fruit and vegetable (FV) intake and FV stage of change in 2 diverse communities engaging with cooperative extension services (Extension). METHODS: Cross-sectional study of FV behaviors of community members enrolled in a team-based challenge offered by Extension. t test and chi-square analyses examined differences in FV intake and FV stage of change. Linear regression examined the relationship between FV stage of change and FV intake, adjusting for demographics...
August 8, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28797710/a-bayesian-system-to-detect-and-characterize-overlapping-outbreaks
#4
John M Aronis, Nicholas E Millett, Michael M Wagner, Fuchiang Tsui, Ye Ye, Jeffrey P Ferraro, Peter J Haug, Per H Gesteland, Gregory F Cooper
Outbreaks of infectious diseases such as influenza are a significant threat to human health. Because there are different strains of influenza which can cause independent outbreaks, and influenza can affect demographic groups at different rates and times, there is a need to recognize and characterize multiple outbreaks of influenza. This paper describes a Bayesian system that uses data from emergency department patient care reports to create epidemiological models of overlapping outbreaks of influenza. Clinical findings are extracted from patient care reports using natural language processing...
August 7, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28790336/identifying-the-mirna-signature-associated-with-survival-time-in-patients-with-lung-adenocarcinoma-using-mirna-expression-profiles
#5
Srinivasulu Yerukala Sathipati, Shinn-Ying Ho
Lung adenocarcinoma is a multifactorial disease. MicroRNA (miRNA) expression profiles are extensively used for discovering potential theranostic biomarkers of lung cancer. This work proposes an optimized support vector regression (SVR) method called SVR-LUAD to simultaneously identify a set of miRNAs referred to the miRNA signature for estimating the survival time of lung adenocarcinoma patients using their miRNA expression profiles. SVR-LUAD uses an inheritable bi-objective combinatorial genetic algorithm to identify a small set of informative miRNAs cooperating with SVR by maximizing estimation accuracy...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783653/cooperative-output-regulation-of-lti-plant-via-distributed-observers-with-local-measurement
#6
Kexin Liu, Yao Chen, Zhisheng Duan, Jinhu Lu
Over the last decades, distributed output regulation problems have received much consideration due to its extensively applications in real world practices. Traditionally, it is assumed that each node obtains the same signal. However, an important observation is that each agent possesses different measurement due to the observability or configuration of the systems. To solve the output regulation problem in this case, we proposed a cooperative output regulation network, where each agent obtains a part of system output measurement on states of plant and exosystem...
August 2, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28768861/positive-and-negative-regulation-of-type-i-interferons-by-the-human-t-cell-leukemia-virus-antisense-protein-hbz
#7
Manraj Singh Narulla, Ahlam Alsairi, Lucie Charmier, Stephen Noonan, David Conroy, William W Hall, Noreen Sheehy
The pathogenesis of human T-cell leukemia virus type 1 (HTLV-1) is strongly linked to the viral regulatory proteins Tax1 and HBZ, whose opposing functions contribute to the clinical outcome of infection. Type I interferons α and β (IFNα and IFNβ) are key cytokines involved in innate immunity and IFNα, in combination with other antivirals, is extensively used in the treatment of HTLV-1 infection. The relationship between HTLV-1 and IFN signaling is unclear and to date the effect of HBZ on this pathway has not been examined...
August 2, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28767083/full-duplex-cooperative-sensing-for-spectrum-heterogeneous-cognitive-radio-networks
#8
Peng Liu, Wangdong Qi, En Yuan, Li Wei, Yuexin Zhao
In cognitive radio networks (CRNs), spectrum sensing is critical for guaranteeing that the opportunistic spectrum access by secondary users (SUs) will not interrupt legitimate primary users (PUs). The application of full-duplex radio to spectrum sensing enables SU to carry out sensing and transmission simultaneously, improving both spectrum awareness and CRN throughput. However, the issue of spectrum sensing with full-duplex radios deployed in heterogeneous environments, where SUs may observe different spectrum activities, has not been addressed...
August 2, 2017: Sensors
https://www.readbyqxmd.com/read/28762864/progesterone-hydroxylation-by-cytochromes-p450-2c-and-3a-enzymes-in-marmoset-liver-microsomes
#9
Kazuyuki Nakanishi, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki, Hiroshi Yamazaki
1. Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical drug metabolism studies. However, the roles of marmoset cytochrome P450 (P450) isoforms in the oxidation of endobiotic progesterone have not been fully investigated. In this study, the roles of marmoset P450 isoforms in progesterone hydroxylation were extensively determined. 2. The activities of liver microsomes from individual marmosets with respect to progesterone 21/17α- and 16α/6β-hydroxylation were significantly correlated with those for flurbiprofen 4-hydroxylation and midazolam 1'-hydroxylation, respectively, as similar correlations have been found in humans...
August 1, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28755954/duality-between-cooperation-and-defection-in-the-presence-of-tit-for-tat-in-replicator-dynamics
#10
Seung Ki Baek, Su Do Yi, Hyeong-Chai Jeong
The prisoner's dilemma describes a conflict between a pair of players, in which defection is a dominant strategy whereas cooperation is collectively optimal. The iterated version of the dilemma has been extensively studied to understand the emergence of cooperation. In the evolutionary context, the iterated prisoner's dilemma is often combined with population dynamics, in which a more successful strategy replicates itself with a higher growth rate. Here, we investigate the replicator dynamics of three representative strategies, i...
July 26, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28752112/lacunar-canalicular-network-in-femoral-cortical-bone-is-reduced-in-aged-women-and-is-predominantly-due-to-a-loss-of-canalicular-porosity
#11
A M Ashique, L S Hart, C D L Thomas, J G Clement, P Pivonka, Y Carter, D D Mousseau, D M L Cooper
The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic extensions, which allow for intercellular communication, and are believed to serve as the mechanosensors that coordinate the processes of bone modeling and remodeling. Imbalances in remodeling, for example, are linked to bone disease, including fragility associated with aging. We have reported that there is a reduction in scale for one component of the LCN, osteocyte lacunar volume, across the human lifespan in females. In the present study, we explore the hypothesis that canalicular porosity also declines with age...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28742450/-keep-me-doing-what-i-love-a-photovoice-evaluation-of-the-missouri-agrability-project
#12
Rebecca Mott, Kimberly Keller, Karen Funkenbusch
The Missouri AgrAbility program links the Cooperative Extension Service at a land-grant university with a nonprofit disability organization to provide practical education and assistance that promotes rural independence. This project utilized Photovoice to describe how Missouri AgrAbility clients perceived how the program impacts their lives. This article relates clients' perceptions of the impact of the AgrAbility program on their lives to the socio-ecologic model framework. Although the primary focus of AgrAbility is to help individuals who have disabilities maintain their independence, all levels of the socio-ecologic model are integral in meeting the needs of program participants...
July 25, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28736411/community-engaged-attribute-mapping-exploring-resources-and-readiness-to-change-the-rural-context-for-obesity-prevention
#13
Deborah John, Tammy Winfield, Lena Etuk, Perry Hystad, Gail Langellotto, Melinda Manore, Kathy Gunter
BACKGROUND: Individual risk factors for obesity are well-known, but environmental characteristics that influence individual risk, especially in rural communities, are not confirmed. Rural communities face unique challenges to implementing environmental strategies, such as walkability, aimed at supporting weight healthy lifestyles. Cooperative Extension, a community-embedded weight health partner, convened and engaged community members in self-exploration of local resources and readiness to change environmental characteristics perceived to promote unhealthy eating and inactivity...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/28727258/changing-systems-through-effective-teams-a-role-for-simulation
#14
Elizabeth D Rosenman, Rosemarie Fernandez, Ambrose H Wong, Michael Cassara, Dylan D Cooper, Maybelle Kou, Torrey A Laack, Ivette Motola, Jessica R Parsons, Benjamin R Levine, James A Grand
Teams are the building blocks of the healthcare system, with growing evidence linking the quality of health care to team effectiveness, and team effectiveness to team training. Simulation has been identified as an effective modality for team training and assessment. Despite this, there are gaps in methodology, measurement, and implementation that prevent maximizing the impact of simulation modalities on team performance. As part of the 2017 Academic Emergency Medicine Consensus Conference "Catalyzing System Change through Health Care Simulation: Systems, Competency, and Outcomes," we explored the impact of simulation on various aspects of team effectiveness...
July 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28723093/plasmonic-aerogels-as-a-three-dimensional-nanoscale-platform-for-solar-fuel-photocatalysis
#15
Paul A DeSario, Jeremy J Pietron, Adam Dunkelberger, Todd H Brintlinger, Olga Baturina, Rhonda M Stroud, Jeffrey C Owrutsky, Debra R Rolison
We use plasmonic Au-TiO2 aerogels as a platform in which to marry synthetically thickened particle-particle junctions in TiO2 aerogel networks to Au∥TiO2 interfaces and then investigate their cooperative influence on photocatalytic hydrogen (H2) generation under both broadband (i.e., UV + visible light) and visible-only excitation. In doing so, we elucidate the dual functions that incorporated Au can play as a water reduction cocatalyst and as a plasmonic sensitizer. We also photodeposit non-plasmonic Pt cocatalyst nanoparticles into our composite aerogels in order to leverage the catalytic water-reducing abilities of Pt...
August 1, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28720468/production-of-a-chikungunya-vaccine-using-a-cho-cell-and-attenuated-viral-based-platform-technology
#16
Preethi Eldi, Tamara H Cooper, Liang Liu, Natalie A Prow, Kerrilyn R Diener, Paul M Howley, Andreas Suhrbier, John D Hayball
Vaccinia-based systems have been extensively explored for the development of recombinant vaccines. Herein we describe an innovative vaccinia virus (VACV)-derived vaccine platform technology termed Sementis Copenhagen Vector (SCV), which was rendered multiplication-defective by targeted deletion of the essential viral assembly gene D13L. A SCV cell substrate line was developed for SCV vaccine production by engineering CHO cells to express D13 and the VACV host-range factor CP77, because CHO cells are routinely used for manufacture of biologics...
July 15, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28714957/il-11-contribution-to-tumorigenesis-in-an-nrf2-addiction-cancer-model
#17
H Kitamura, Y Onodera, S Murakami, T Suzuki, H Motohashi
The interaction between cancer cells and their microenvironment is an important determinant of the pathological nature of cancers, particularly their tumorigenic abilities. The KEAP1-NRF2 system, originally identified as a critical defense mechanism against oxidative stress, is often dysregulated in various human cancers forming solid tumors, resulting in the aberrant activation of NRF2. Increased accumulation of NRF2 in cancers is strongly associated with the poor prognoses of cancer patients, including those with lung and breast cancers...
July 17, 2017: Oncogene
https://www.readbyqxmd.com/read/28714285/dynamic-cooperation-of-hydrogen-binding-and-%C3%AF-stacking-in-ssdna-adsorption-on-graphene-oxide
#18
Zhen Xu, Xiaoling Lei, Yusong Tu, Zhi-Jie Tan, Bo Song, Haiping Fang
Functional nanoscale structures consisting of a DNA molecule coupled to graphene or graphene oxide (GO) have great potential for applications in biosensors, biomedicine, nanotechnology, and materials science. Extensive studies using the most sophisticated experimental techniques and theoretical methods have still not clarified the dynamic process of single-stranded DNA (ssDNA) adsorbed on a GO surface. Based on a molecular dynamics simulation, this work shows that an ssDNA segment could be stably adsorbed on a GO surface through hydrogen bonding and a π-π stacking interaction, with preferential binding to an oxidized region rather than to an unoxidized region of the GO surface...
July 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28704143/north-carolina-state-agencies-working-to-prevent-agricultural-injuries-and-illnesses
#19
Ricky Langley, Anne Hirsch, Regina Cullen, John Allran, Renee Woody, Derrick Bell
Over the past 25 years, the North Carolina Departments of Labor, Agriculture and Consumer Services, and Health and Human Services have worked with farmers, farmworkers, commodity and trade associations, universities, and cooperative extension agents to develop programs to decrease the occurrence of injuries and illnesses among agricultural workers and their families. The Bureau of Agricultural Safety and Health in the North Carolina Department of Labor helped craft the Migrant Housing Act, created the Gold Star program, and developed numerous projects promoting rural highway safety and farm safety...
July 13, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28694328/the-contribution-of-the-c5-protein-subunit-of-escherichia-coli-ribonuclease-p-to-specificity-for-precursor-trna-is-modulated-by-proximal-5-leader-sequences
#20
Courtney Nicole Niland, David R Anderson, Eckhard Jankowsky, Michael E Harris
Molecular recognition of RNA by RNA processing enzymes and RNA binding proteins often involves the cooperation between multiple subunits. However, the interdependent contributions of RNA and protein subunits to molecular recognition by ribonucleoproteins and protein-protein complexes is relatively unexplored. RNase P is an endonuclease that removes 5' leaders from precursor tRNAs and functions in bacteria as dimer formed by a catalytic RNA subunit (P RNA) and a protein subunit (C5 in E. coli). The P RNA subunit contacts the tRNA body and proximal 5' leader sequences (N(-1) and N(-2)) while C5 binds distal 5' leader sequences (N(-3) to N(-6))...
July 10, 2017: RNA
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