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Cooperative extension

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https://www.readbyqxmd.com/read/28917115/comparisons-of-depression-anxiety-well-being-and-perceptions-of-the-built-environment-amongst-adults-seeking-social-intermediate-and-market-rent-accommodation-in-the-former-london-olympic-athletes-village
#1
Bina Ram, Aparna Shankar, Claire M Nightingale, Billie Giles-Corti, Anne Ellaway, Ashley R Cooper, Angie Page, Steven Cummins, Daniel Lewis, Peter H Whincup, Derek G Cook, Alicja R Rudnicka, Christopher G Owen
The Examining Neighbourhood Activities in Built Living Environments in London (ENABLE London) study provides a unique opportunity to examine differences in mental health and well-being amongst adults seeking social, intermediate (affordable rent), and market-rent housing in a purpose built neighbourhood (East Village, the former London 2012 Olympic Athletes' Village), specifically designed to encourage positive health behaviours. Multi-level logistic regression models examined baseline differences in levels of depression, anxiety and well-being across the housing groups...
September 13, 2017: Health & Place
https://www.readbyqxmd.com/read/28916782/predicting-clinical-outcomes-from-large-scale-cancer-genomic-profiles-with-deep-survival-models
#2
Safoora Yousefi, Fatemeh Amrollahi, Mohamed Amgad, Chengliang Dong, Joshua E Lewis, Congzheng Song, David A Gutman, Sameer H Halani, Jose Enrique Velazquez Vega, Daniel J Brat, Lee A D Cooper
Translating the vast data generated by genomic platforms into accurate predictions of clinical outcomes is a fundamental challenge in genomic medicine. Many prediction methods face limitations in learning from the high-dimensional profiles generated by these platforms, and rely on experts to hand-select a small number of features for training prediction models. In this paper, we demonstrate how deep learning and Bayesian optimization methods that have been remarkably successful in general high-dimensional prediction tasks can be adapted to the problem of predicting cancer outcomes...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28914753/on-optimal-cooperative-sensing-with-energy-detection-in-cognitive-radio
#3
Sunghwan Bae, Jaewoo So, Hongseok Kim
In this paper, we propose an optimal cooperative sensing technique for cognitive radio to maximize sensing performance based on energy detection. In most spectrum sensing research, many cooperation methods have been proposed to overcome the sensitivity of energy detection so that both primary and secondary users are better off in terms of spectral efficiency. However, without assigning a proper sensing threshold to each sensing node, cooperation may not be effective unless the received average primary user signal-to-noise ratio (SNR) is identical...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28911100/genome-wide-analysis-of-influenza-viral-rna-and-nucleoprotein-association
#4
Nara Lee, Valerie Le Sage, Adalena V Nanni, Dan J Snyder, Vaughn S Cooper, Seema S Lakdawala
Influenza A virus (IAV) genomes are composed of eight single-stranded RNA segments that are coated by viral nucleoprotein (NP) molecules. Classically, the interaction between NP and viral RNA (vRNA) is depicted as a uniform pattern of 'beads on a string'. Using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP), we identified the vRNA binding profiles of NP for two H1N1 IAV strains in virions. Contrary to the prevailing model for vRNA packaging, NP does not bind vRNA uniformly in the A/WSN/1933 and A/California/07/2009 strains, but instead each vRNA segment exhibits a unique binding profile, containing sites that are enriched or poor in NP association...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28904173/impact-of-metastasectomy-in-the-multimodality-approach-for-braf-v600e-metastatic-colorectal-cancer-the-mayo-clinic-experience
#5
Benny Johnson, Zhaohui Jin, Mark J Truty, Rory L Smoot, David M Nagorney, Michael L Kendrick, Benjamin R Kipp, Axel Grothey
BACKGROUND: BRAF V600E mutations are present in 8%-10% of patients with metastatic colorectal cancer (mCRC) and portend poor prognosis. This study investigated the impact of metastasectomy for patients with BRAF V600E mCRC. Subjects, Materials, and Methods . Using prospective clinical and molecular data, patients with BRAF V600E mCRC were analyzed for clinical characteristics and survival. Statistical analyses utilized the Kaplan-Meier method, log-rank test, and Cox proportional hazard models...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28893819/agriculture-and-health-sectors-collaborate-in-addressing-population-health
#6
Arthur Kaufman, Jon Boren, Sonja Koukel, Francisco Ronquillo, Cindy Davies, Carolina Nkouaga
PURPOSE: Population health is of growing importance in the changing health care environment. The Cooperative Extension Service, housed in each state's land grant university, has a major impact on population health through its many community-based efforts, including the Supplemental Nutrition Assistance Program - Education (SNAP-Ed) nutrition programs, 4-H youth engagement, health and wellness education, and community development. Can the agricultural and health sectors, which usually operate in parallel, mostly unknown to each other, collaborate to address population health? We set out to provide an overview of the collaboration between the Cooperative Extension Service and the health sector in various states and describe a case study of 1 model as it developed in New Mexico...
September 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28892771/exclusive-e-cigarette-use-predicts-cigarette-initiation-among-college-students
#7
Alexandra Loukas, C Nathan Marti, Maria Cooper, Keryn E Pasch, Cheryl L Perry
INTRODUCTION: An increasing body of research indicates that use of electronic nicotine delivery systems (ENDS) predicts cigarette initiation. However, no studies examine if risk for cigarette initiation varies for exclusive ENDS users versus users of ENDS and other tobacco products. This study examined if: a) cigarette-naïve young adults (i.e., never cigarette users) who ever used ENDS had a greater odds of initiating cigarettes than non-ENDS users over a 1.5year period and b) the odds of cigarette initiation was consistent across exclusive ENDS users and users of ENDS and at least one tobacco product...
August 31, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28891385/trauma-informed-parenting-classes-delivered-to-rural-kinship-parents-a-pilot-study
#8
Karen J Foli, Stephanie Woodcox, Susan Kersey, Lingsong Zhang, Brooke Wilkinson
BACKGROUND: Without an informed approach, kinship parents, often grandparents, may struggle to effectively interact with their children who have experienced trauma. OBJECTIVES: The purpose of this pilot study was to describe the overall impact and acceptability of a trauma-informed parenting curriculum delivered to 16 rural-dwelling kinship parents. Nursing faculty partnered with Cooperative Extension Educators to deliver this curriculum, developed by the National Child Traumatic Stress Network...
September 1, 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28887860/regulation-of-radial-glial-process-growth-by-glutamate-via-mglur5-trpc3-and-neuregulin-erbb4
#9
Lauri M Louhivuori, Pauli M Turunen, Verna Louhivuori, Venkatram Yellapragada, Tommy Nordström, Per Uhlén, Karl E Åkerman
Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate receptor 5 (mGluR5) function retards the growth of radial glial processes in vitro. Neuregulins (NRG) are activated by proteolytic cleavage and regulate (radial) glial maintenance via ErbB3/ErbB4 receptors. We show here that blocking ErbB4 disrupts radial process extension. Soluble NRG acting on ErbB4 receptors is able to promote radial process extension in particular where process elongation has been impeded by blockade of mGluR5, the nonselective cation channel canonical transient receptor potential 3 (TRPC3), or matrix metalloproteases (MMP)...
September 9, 2017: Glia
https://www.readbyqxmd.com/read/28882724/evaluation-of-the-scientific-impact-of-the-ebola-epidemic-a-systematic-review
#10
REVIEW
Nico T Mutters, Veronika Malek, Selidji T Agnandji, Frank Günther, Evelina Tacconelli
OBJECTIVES: The Ebola outbreak prompted an extensive number of scientific publications. Yet little attention has been paid to the involvement of scientific communities, the scientific impact as well as provided funding. We sought to systematically review publicly available information on the scientific impact of the Ebola epidemic. METHODS: A systematic review of scientific literature was performed. Information on the scientific impact of the Ebola epidemic including the involvement of scientific communities by determining the origins, funding, and impact factor (IF) of publications between December 6, 2013, and December 22, 2015 were included...
September 4, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28881985/popfba-tackling-intratumour-heterogeneity-with-flux-balance-analysis
#11
Chiara Damiani, Marzia Di Filippo, Dario Pescini, Davide Maspero, Riccardo Colombo, Giancarlo Mauri
Motivation: Intratumour heterogeneity poses many challenges to the treatment of cancer. Unfortunately, the transcriptional and metabolic information retrieved by currently available computational and experimental techniques portrays the average behaviour of intermixed and heterogeneous cell subpopulations within a given tumour. Emerging single-cell genomic analyses are nonetheless unable to characterize the interactions among cancer subpopulations. In this study, we propose popFBA , an extension to classic Flux Balance Analysis, to explore how metabolic heterogeneity and cooperation phenomena affect the overall growth of cancer cell populations...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28872698/a-multivariate-distance-based-analytic-framework-for-microbial-interdependence-association-test-in-longitudinal-study
#12
Yilong Zhang, Sung Won Han, Laura M Cox, Huilin Li
Human microbiome is the collection of microbes living in and on the various parts of our body. The microbes living on our body in nature do not live alone. They act as integrated microbial community with massive competing and cooperating and contribute to our human health in a very important way. Most current analyses focus on examining microbial differences at a single time point, which do not adequately capture the dynamic nature of the microbiome data. With the advent of high-throughput sequencing and analytical tools, we are able to probe the interdependent relationship among microbial species through longitudinal study...
September 5, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28870291/genomic-characterization-of-an-extensively-drug-resistance-salmonella-enterica-serotype-indiana-strain-harboring-blandm-1-gene-isolated-from-a-chicken-carcass-in-china
#13
Wei Wang, Zixin Peng, Zulqarnain Baloch, Yujie Hu, Jin Xu, Wenhui Zhang, Séamus Fanning, Fengqin Li
OBJECTIVES: The objective of this study was to genetically characterize the antimicrobial resistance mechanisms of Salmonella enterica serotype Indiana C629 isolated from a chicken carcass in China in 2014. METHODS: Antimicrobial susceptibility against a panel of 23 antimicrobial agents was carried out on Salmonella enterica serotype Indiana C629 and assessed according to CLSI standards. Whole-genome sequencing of this isolate was conducted to obtain the complete genome of S...
November 2017: Microbiological Research
https://www.readbyqxmd.com/read/28868297/a-toddler-presenting-with-pulmonary-renal-syndrome
#14
Florence A Aeschlimann, Rae S M Yeung, Ronald M Laxer, Diane Hebert, Ashley Cooper, Rose Chami, Damien Noone
Pulmonary renal syndrome refers to an association of pulmonary and glomerular disease and includes disorders, such as the ANCA-associated vasculitides, anti-glomerular basement membrane antibody disease, systemic lupus erythematosus, and IgA vasculitis (Henoch-Schönlein purpura). We present the medical history of a 26-month-old boy with an extensive purpuric rash, involving the limbs, trunk, and face, who developed clinically significant pulmonary hemorrhage and renal involvement. Rapid recognition of this rare but potentially life-threatening condition is crucial...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/28867801/an-unusual-dimeric-inhibitor-of-acetylcholinesterase-cooperative-binding-of-crystal-violet
#15
Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekström
Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for treatment of various cholinergic deficiencies, including Alzheimer's disease and myasthenia gravis. In a previous high throughput screening campaign, we identified the dye crystal violet (CV) as an inhibitor of AChE. Herein, we show that CV displays a significant cooperativity for binding to AChE, and the molecular basis for this observation has been investigated by X-ray crystallography...
August 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28862979/negative-pressure-wound-therapy-for-a-giant-wound-secondary-to-malignancy-induced-necrotizing-fasciitis-case-report-and-review-of-the-literature
#16
Jiayi Hu, Serge Goekjian, Nicolas Stone, Alexandra Nelson, Michael James Cooper
BACKGROUND: Necrotizing fasciitis (NF) is a life-threatening condition in which rapid diagnosis, debridement of nonviable tissue, and broad-spectrum antibiotics are critical to effective treatment. The debridement required can be extensive, resulting in large wounds that can sometimes be covered with split-thickness skin grafts (STSGs) with the help of negative pressure wound therapy (NPWT), or vacuum-assisted closure, to decrease the wound size. CASE REPORT: The authors report a rare case of NF due to malignancy-associated bowel perforation with a giant lower extremity wound secondary to debridement that involved 20% of the total body surface area (TBSA) in a 64-year-old, previously healthy, nonsmoking man...
August 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28855032/-prognostic-and-predictive-value-of-thyroid-transcription-factor-1-cd56-p40-and-other-clinical-characteristics-in-small-cell-lung-cancer-patients
#17
Xin Wang, Yi Zhang, Mu Hu, Ruotian Wang, Lei Liu, Kun Qian, Yuanbo Li, Xiuyi Zhi
BACKGROUND: The aim of this study is to explore roles of thyroid transcription factor-1 (TTF-1), CD56, P40 expression and other clinical characteristics predicting response and survival in patients with small cell lung cancer (SCLC). METHODS: Formalin-fixed, paraffin-embedded biopsy tissues were retrospectively obtained from 198 SCLC patients who were diagnosed first in Xuanwu Hospital. The expressions of TTF-1, CD56 and P40 were detected by immunohistochemistry...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28852571/glycerol-kinase-like-proteins-cooperate-with-pld6-in-regulating-sperm-mitochondrial-sheath-formation-and-male-fertility
#18
Yuxi Chen, Puping Liang, Yan Huang, Minyan Li, Xiya Zhang, Chenhui Ding, Junyan Feng, Zhen Zhang, Xueqing Zhang, Yuanzhu Gao, Qinfeng Zhang, Shanbo Cao, Haiyan Zheng, Dan Liu, Zhou Songyang, Junjiu Huang
Spermatids undergo the final steps of maturation during spermiogenesis, a process that necessitates extensive rearrangement of organelles such as the mitochondria. Male infertility has been linked to mitochondrial disorder, for example, hypospermatogenesis and asthenozoospermia. However, the mechanisms that regulate mitochondrial dynamics during spermiogenesis remain largely unknown. We found the glycerol kinase (Gyk)-like proteins glycerol kinase-like 1 (Gykl1) and glycerol kinase 2 (Gk2) were specifically localized to the mitochondria in spermatids...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28842688/light-independent-phospholipid-scramblase-activity-of-bacteriorhodopsin-from-halobacterium-salinarum
#19
Alice Verchère, Wei-Lin Ou, Birgit Ploier, Takefumi Morizumi, Michael A Goren, Peter Bütikofer, Oliver P Ernst, George Khelashvili, Anant K Menon
The retinylidene protein bacteriorhodopsin (BR) is a heptahelical light-dependent proton pump found in the purple membrane of the archaeon Halobacterium salinarum. We now show that when reconstituted into large unilamellar vesicles, purified BR trimers exhibit light-independent lipid scramblase activity, thereby facilitating transbilayer exchange of phospholipids between the leaflets of the vesicle membrane at a rate >10,000 per trimer per second. This activity is comparable to that of recently described scramblases including bovine rhodopsin and fungal TMEM16 proteins...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842549/roles-of-mir319-and-tcp-transcription-factors-in-leaf-development
#20
Tomotsugu Koyama, Fumihiko Sato, Masaru Ohme-Takagi
Sophisticated regulation of gene expression, including microRNAs (miRNAs) and their target genes, is required for leaf differentiation, growth, and senescence. The impact of miR319 and its target TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL NUCLEAR ANTIGEN BINDING FACTOR (TCP) genes on leaf development has been extensively investigated, but the redundancies of these gene families often interfere with the evaluation of their function and regulation in the developmental context. Here, we present the genetic evidence of the involvement of the MIR319 and TCP gene families in Arabidopsis thaliana leaf development...
August 25, 2017: Plant Physiology
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