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Cooperative extension

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https://www.readbyqxmd.com/read/28227620/routing-over-multi-hop-fading-wireless-body-area-networks-with-reliability-considerations
#1
Hussein Moosavi, Francis Minhthang Bui, Hussein Moosavi, Francis Minhthang Bui, Francis Minhthang Bui, Hussein Moosavi
Optimal reliable routing is studied in the context of fading wireless body area networks (WBANs). A non-cooperative game is proposed to model and analyze the strategic interactions among body-worn health-care devices when each seeks to find the most reliable path to the hub. A distributed algorithm based on the proposed game is provided and proved to converge to a multi-hop Pareto-dominant Nash topology. The game-theoretic framework is evaluated through numerical simulations in conditions approximating actual deployment of a moving ultra wideband WBAN...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28208593/context-sensing-system-analysis-for-privacy-preservation-based-on-game-theory
#2
Shengling Wang, Luyun Li, Weiman Sun, Junqi Guo, Rongfang Bie, Kai Lin
In a context sensing system in which a sensor-equipped mobile phone runs an unreliable context-aware application, the application can infer the user's contexts, based on which it provides personalized services. However, the application may sell the user's contexts to some malicious adversaries to earn extra profits, which will hinder its widespread use. In the real world, the actions of the user, the application and the adversary in the context sensing system affect each other, so that their payoffs are constrained mutually...
February 10, 2017: Sensors
https://www.readbyqxmd.com/read/28199843/the-sin3a-hdac-corepressor-complex-functionally-cooperates-with-nanog-to-promote-pluripotency
#3
Arven Saunders, Xin Huang, Miguel Fidalgo, Michael H Reimer, Francesco Faiola, Junjun Ding, Carlos Sánchez-Priego, Diana Guallar, Carmen Sáenz, Dan Li, Jianlong Wang
Although SIN3A is required for the survival of early embryos and embryonic stem cells (ESCs), the role of SIN3A in the maintenance and establishment of pluripotency remains unclear. Here, we find that the SIN3A/HDAC corepressor complex maintains ESC pluripotency and promotes the generation of induced pluripotent stem cells (iPSCs). Members of the SIN3A/HDAC corepressor complex are enriched in an extended NANOG interactome and function in transcriptional coactivation in ESCs. We also identified a critical role for SIN3A and HDAC2 in efficient reprogramming of somatic cells...
February 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28182707/win-stay-lose-learn-promotes-cooperation-in-the-prisoner-s-dilemma-game-with-voluntary-participation
#4
Chen Chu, Jinzhuo Liu, Chen Shen, Jiahua Jin, Lei Shi
Voluntary participation, demonstrated to be a simple yet effective mechanism to promote persistent cooperative behavior, has been extensively studied. It has also been verified that the aspiration-based win-stay-lose-learn strategy updating rule promotes the evolution of cooperation. Inspired by this well-known fact, we combine the Win-Stay-Lose-Learn updating rule with voluntary participation: Players maintain their strategies when they are satisfied, or players attempt to imitate the strategy of one randomly chosen neighbor...
2017: PloS One
https://www.readbyqxmd.com/read/28181666/a-partnership-model-to-improve-population-health-screening-for-noncommunicable-conditions-and-their-common-risk-factors-qazvin-islamic-republic-of-iran
#5
S Alikhani, B Damari
Early findings and management of health conditions are among the key functions of health care systems. We developed a partnership framework to establish an extended primary health care-based selective screening service for the entire population of a small town as a key project of Qazvin Health Plan, Qazvin, Islamic Republic of Iran. Eight scientific associations and a diverse technical taskforce extensively reviewed evidence to adapt the grade A and B preventive recommendations of the American Preventive Service Taskforce...
February 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28177216/bacterioferritin-structure-dynamics-and-protein-protein-interactions-at-play-in-iron-storage-and-mobilization
#6
Mario Rivera
Despite its essentiality to life, iron presents significant challenges to cells: the exceedingly low solubility of Fe(3+) limits its bioavailability, and the reactivity of Fe(2+) toward H2O2 is a source of the toxic hydroxyl radical (HO(•)). Consequently, cellular levels of free iron are highly regulated to ensure sufficiency while preventing iron-induced toxicity. Relatively little is known about the fate of iron in the bacterial cytosol or how cells balance the need for relatively high cytosolic iron concentrations with the potential toxicity of the nutrient...
February 8, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28174598/review-on-the-role-of-the-human-polyomavirus-jc-in-the-development-of-tumors
#7
REVIEW
Serena Delbue, Manola Comar, Pasquale Ferrante
Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue. We focused our attention on the human Polyomavirus JC (JCPyV), that is a small, naked DNA virus, belonging to the Polyomaviridae family. It is the recognized etiological agent of the Progressive Multifocal Leukoencephalopathy (PML), a fatal demyelinating disease, occurring in immunosuppressed individuals...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28163801/evolutionary-biosemiotics-and-multilevel-construction-networks
#8
Alexei A Sharov
In contrast to the traditional relational semiotics, biosemiotics decisively deviates towards dynamical aspects of signs at the evolutionary and developmental time scales. The analysis of sign dynamics requires constructivism (in a broad sense) to explain how new components such as subagents, sensors, effectors, and interpretation networks are produced by developing and evolving organisms. Semiotic networks that include signs, tools, and subagents are multilevel, and this feature supports the plasticity, robustness, and evolvability of organisms...
December 2016: Biosemiotics
https://www.readbyqxmd.com/read/28160784/assistive-technology-pricing-in-australia-is-it-efficient-and-equitable
#9
Michael P Summers, George Verikios
Objective To examine available systematically collected evidence regarding prices for assistive technology (AT; e.g. disability aids and equipment) in Australia with other comparable countries. Issues of appropriate AT pricing are coming to the fore as a consequence of efforts to move to consumer-centric purchasing decisions with the National Disability Insurance Scheme (NDIS) and also in the recent aged care reforms.Methods We identified and present three sets of AT price comparisons. Two comparisons were based solely on the lowest prices advertised on the internet, and one comparison examined recommended retail prices...
February 6, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28155718/improved-protein-protein-interactions-prediction-via-weighted-sparse-representation-model-combining-continuous-wavelet-descriptor-and-pseaa-composition
#10
Yu-An Huang, Zhu-Hong You, Xing Chen, Gui-Ying Yan
BACKGROUND: Protein-protein interactions (PPIs) are essential to most biological processes. Since bioscience has entered into the era of genome and proteome, there is a growing demand for the knowledge about PPI network. High-throughput biological technologies can be used to identify new PPIs, but they are expensive, time-consuming, and tedious. Therefore, computational methods for predicting PPIs have an important role. For the past years, an increasing number of computational methods such as protein structure-based approaches have been proposed for predicting PPIs...
December 23, 2016: BMC Systems Biology
https://www.readbyqxmd.com/read/28148957/cooperative-expression-of-atomic-chirality-in-inorganic-nanostructures
#11
Peng-Peng Wang, Shang-Jie Yu, Alexander O Govorov, Min Ouyang
Cooperative chirality phenomena extensively exist in biomolecular and organic systems via intra- and inter-molecular interactions, but study of inorganic materials has been lacking. Here we report, experimentally and theoretically, cooperative chirality in colloidal cinnabar mercury sulfide nanocrystals that originates from chirality interplay between the crystallographic lattice and geometric morphology at different length scales. A two-step synthetic scheme is developed to allow control of critical parameters of these two types of handedness, resulting in different chiral interplays expressed as observables through materials engineering...
February 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28139737/histone-h4-expression-is-cooperatively-maintained-by-ikk%C3%AE-and-akt1-which-attenuates-cisplatin-induced-apoptosis-through-the-dna-pk-rip1-iaps-signaling-cascade
#12
Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wang
While chromatin remodeling mediated by post-translational modification of histone is extensively studied in carcinogenesis and cancer cell's response to chemotherapy and radiotherapy, little is known about the role of histone expression in chemoresistance. Here we report a novel chemoresistance mechanism involving histone H4 expression. Extended from our previous studies showing that concurrent blockage of the NF-κB and Akt signaling pathways sensitizes lung cancer cells to cisplatin-induced apoptosis, we for the first time found that knockdown of Akt1 and the NF-κB-activating kinase IKKβ cooperatively downregulated histone H4 expression, which increased cisplatin-induced apoptosis in lung cancer cells...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137276/towards-standardization-of-next-generation-sequencing-of-ffpe-samples-for-clinical-oncology-intrinsic-obstacles-and-possible-solutions
#13
Maxim Ivanov, Konstantin Laktionov, Valery Breder, Polina Chernenko, Ekaterina Novikova, Ekaterina Telysheva, Sergey Musienko, Ancha Baranova, Vladislav Mileyko
BACKGROUND: Next generation sequencing has a potential to revolutionize the management of cancer patients within the framework of precision oncology. Nevertheless, lack of standardization decelerated entering of the technology into the clinical testing space. Here we dissected a number of common problems of NGS diagnostics in oncology and introduced ways they can be resolved. METHODS: DNA was extracted from 26 formalin fixed paraffin embedded (FFPE) specimens and processed with the TrueSeq Amplicon Cancer Panel (Illumina Inc, San Diego, California) targeting 48 cancer-related genes and sequenced in single run...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28137246/functional-outcome-and-complications-after-the-microsurgical-removal-of-giant-vestibular-schwannomas-via-the-retrosigmoid-approach-a-retrospective-review-of-16-year-experience-in-a-single-hospital
#14
Xiang Huang, Jian Xu, Ming Xu, Mingyu Chen, Kaiyuan Ji, Junwei Ren, Ping Zhong
BACKGROUND: Intracranial vestibular schwannoma still remain to be difficulty for its unique microsurgical technique and preservation of neuro-function, as well as reducing common complications that may arise in surgery. METHODS: We consecutively enrolled 657 unilateral giant (>4 cm diameter) vestibular schwannoma patients treated in Huashan Hospital via the suboccipital retrosigmoid approach in the past 16 years. The extension of tumor removal, surgical mortality, facial nerve function, hearing, and the other main short and long-term complications were the studied parameters...
January 31, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28126844/identification-of-phosphorylation-sites-altering-pollen-soluble-inorganic-pyrophosphatase-activity
#15
Deborah J Eaves, Tamanna Haque, Richard L Tudor, Yoshimi Barron, Cleidiane G Zampronio, Nicholas P J Cotton, Barend H J de Graaf, Scott A White, Helen J Cooper, F Christopher H Franklin, Jeffrey F Harper, Vernonica E Franklin-Tong
Protein phosphorylation regulates numerous cellular processes. Identifying the substrates and protein kinases involved is vital to understand how these important post-translational modifications modulate biological function in eukaryotic cells. Pyrophosphatases catalyse the hydrolysis of PPi to Pi, driving biosynthetic reactions; they are essential for low cytosolic PPi. It was recently suggested that post-translational regulation of Family I soluble inorganic pyrophosphatases (sPPases) may affect their activity...
January 26, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28108107/barth-syndrome-with-late-onset-cardiomyopathy-a-missed-opportunity-for-diagnosis
#16
Leanne Woiewodski, David Ezon, James Cooper, Brian Feingold
A male infant presented with neutropenia, growth delay, and death of a maternal uncle at age 2 years. Despite extensive evaluation over 10 years, Barth syndrome was not diagnosed until he presented in acute heart failure. Although late-onset cardiomyopathy is rare, persistence of common Barth features should have enabled earlier diagnosis.
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28105482/-surgery-of-sepsis-in-orthopedics-and-trauma-a-highlight-current-survey-by-the-section-for-bone-and-soft-tissue-infections-of-the-german-society-for-orthopedics-and-trauma
#17
M Militz, W Popp, R Hoffmann, R Ascherl, A Tiemann
Surgery of sepsis in trauma surgery and orthopedics is attracting increasingly more attention due to the rising presence of multidrug-resistant pathogens and the increasing number of operative interventions. Despite extensive experience over decades neither the symptoms nor the treatment strategies have been evaluated and it has become obvious that a scientific investigation of this complex topic is necessary for optimization of patient care under economically sound conditions. The aim of this article is to give a snapshot from German healthcare institutions for trauma surgery and orthopedics to answer some questions on this topic from the section for bone and soft tissue infections (SeKuWi) of the German Society for Orthopedics and Trauma (DGOU) in cooperation with the German Society for Hospital Hygiene (DGKH)...
January 19, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28099470/a-gene-oriented-haplotype-comparison-reveals-recently-selected-genomic-regions-in-temperate-and-tropical-maize-germplasm
#18
Cheng He, Junjie Fu, Jie Zhang, Yongxiang Li, Jun Zheng, Hongwei Zhang, Xiaohong Yang, Jianhua Wang, Guoying Wang
The extensive genetic variation present in maize (Zea mays) germplasm makes it possible to detect signatures of positive artificial selection that occurred during temperate and tropical maize improvement. Here we report an analysis of 532,815 polymorphisms from a maize association panel consisting of 368 diverse temperate and tropical inbred lines. We developed a gene-oriented approach adapting exonic polymorphisms to identify recently selected alleles by comparing haplotypes across the maize genome. This analysis revealed evidence of selection for more than 1100 genomic regions during recent improvement, and included regulatory genes and key genes with visible mutant phenotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28088857/methane-activation-by-tantalum-carbide-cluster-anions-ta2c4
#19
Hai-Fang Li, Yan-Xia Zhao, Zhen Yuan, Qing-Yu Liu, Zi-Yu Li, Xiao-Na Li, Chuan-Gang Ning, Sheng-Gui He
Methane activation by transition metals is of fundamental interest and practical importance, as this process is extensively involved in the natural gas conversion to fuels and value-added chemicals. While single-metal centers have been well recognized as active sites for methane activation, the active center composed of two or more metal atoms is rarely addressed and the detailed reaction mechanism remains unclear. Here, by using state-of-the-art time-of-flight mass spectrometry, cryogenic anion photoelectron imaging spectroscopy, and quantum-chemical calculations, the cooperation of the two Ta atoms in a dinuclear carbide cluster Ta2C4(-) for methane activation has been identified...
January 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28087991/an-exceptionally-selective-dna-cooperatively-binding-two-ca2-ions
#20
Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding, Juewen Liu
Ca2+ is a highly important metal ion in biology and in the environment, leading to extensive work in developing sensors for Ca2+ detection. While many Ca2+ binding proteins are known, few nucleic acids can selectively bind Ca2+. DNA-based biosensors are attractive for its high stability and excellent programmability. Herein, we report a RNA-cleaving DNAzyme named EtNa cooperatively binding two Ca2+ ions but only one Mg2+. Four DNAzymes with known Ca2+-dependent activity were compared, and the EtNa has the best selectivity...
January 14, 2017: Chembiochem: a European Journal of Chemical Biology
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