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https://www.readbyqxmd.com/read/28639641/incorporation-of-click-chemistry-glycomimetics-dramatically-alters-triple-helix-stability-in-an-adiponectin-model-peptide
#1
Katherine R Lutteroth, Paul W R Harris, Tom H Wright, Harveen Kaur, Kevin Sparrow, Sung-Hyun Yang, Garth J S Cooper, Margaret A Brimble
Adiponectin (Adpn) has been shown to be a possible therapeutic for Type II diabetes, however the production of a therapeutic version of Adpn has proved to be challenging. Biological studies have highlighted the importance of the glycosylated lysine residues for the formation of bioactive high molecular weight oligomers of Adpn. Through the use of 'click' glycopeptide mimetics, we investigated the role of glycosylated lysine and serine residues for the formation of triple helical structures of the collagenous domain of Adpn, in the context of a collagen model peptide scaffold...
June 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28635122/sketching-the-invisible-to-predict-the-visible-from-drawing-to-modeling-in-chemistry
#2
Melanie M Cooper, Mike Stieff, Dane DeSutter
Sketching as a scientific practice goes beyond the simple act of inscribing diagrams onto paper. Scientists produce a wide range of representations through sketching, as it is tightly coupled to model-based reasoning. Chemists in particular make extensive use of sketches to reason about chemical phenomena and to communicate their ideas. However, the chemical sciences have a unique problem in that chemists deal with the unseen world of the atomic-molecular level. Using sketches, chemists strive to develop causal mechanisms that emerge from the structure and behavior of molecular-level entities, to explain observations of the macroscopic visible world...
June 21, 2017: Topics in Cognitive Science
https://www.readbyqxmd.com/read/28633689/the-relationship-between-community-nutritionists-use-of-policy-systems-and-environmental-strategies-to-prevent-obesity-and-its-determinants-depends-on-networking
#3
Angela H Lu, Katherine L Dickin, Mark A Constas, Jamie S Dollahite
OBJECTIVE: To apply the Theory of Planned Behaviour to examine the relationship between the constructs of background factors and beliefs towards using policy, systems and environmental (PSE) strategies and reported use of PSE strategies to prevent obesity by a group of professional nutrition educators. DESIGN: Cross-sectional study using self-reported survey. SETTING: Cooperative Extension in New York, USA. SUBJECTS: Nutrition educators (n 58); survey response rate 100 %...
June 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28630726/the-hapi-hip-arthroscopy-pre-habilitation-intervention-study-does-pre-habilitation-affect-outcomes-in-patients-undergoing-hip-arthroscopy-for-femoro-acetabular-impingement
#4
Louise F Grant, Derek J Cooper, Jon L Conroy
The purpose of this randomized prospective comparative controlled pilot study was to determine whether specific patient exercises done pre-hip arthroscopy surgery for femoro-acetabular impingement affected post-operative recovery. Between October 2013 and June 2014, 6 males and twelve females over the age of eighteen, who were listed for hip arthroscopy for femoro-acetabular impingement, were randomized into two groups. A hip-specific, 8-week home exercise programme was given to the experimental group before their surgery...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28626370/donor-safety-in-haemapheresis-development-of-an-internet-based-registry-for-comprehensive-assessment-of-adverse-events-from-healthy-donors
#5
Hans-Gert Heuft, Eike Fischer, Tina Weingand, Thomas Burkhardt, Gerda Leitner, Hagen Baume, Jörg-Peter Schmidt, Andreas Buser, Gabriele Fauchald, Ute Reinicke Voigt, Behrouz Mansouri-Taleghani
BACKGROUND: Currently, there is an extensive but highly inconsistent body of literature regarding donor adverse events (AEs) in haemapheresis. As the reports diverge with respect to types and grading of AEs, apheresis procedures and machines, the range of haemapheresis-related AEs varies widely from about 0.03% to 6.6%. METHODS: The German Society for Transfusion Medicine and Immunohaematology (DGTI) formed a 'Haemapheresis Vigilance Working Party' (Arbeitsgemeinschaft Hämapheresevigilanz; AGHV) to create an on-line registry for comprehensive and comparable AE assessment with all available apheresis devices in all types of preparative haemapheresis: plasmapheresis (PLS), plateletpheresis (PLT), red blood cell apheresis, all kind of leukaphereses (autologous/allogeneic blood stem cell apheresis, granulocyte apheresis, lymphocyte/monocyte apheresis) and all possible types of multi-component apheresis...
June 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28625790/preprotein-conformational-dynamics-drive-bivalent-translocase-docking-and-secretion
#6
Marios Frantzeskos Sardis, Alexandra Tsirigotaki, Katerina Elias Chatzi, Athina George Portaliou, Giorgos Gouridis, Spyridoula Karamanou, Anastassios Economou
Most bacterial secretory proteins destined beyond the plasma membrane are secreted post-translationally by the Sec translocase. In the first step of translocation, preproteins are targeted for binding to their 2-site receptor SecA, the peripheral ATPase subunit of the translocase. We now reveal that secretory preproteins use a dual-key mechanism to bridge the signal peptide and mature domain receptor sites and cooperatively enhance their affinities. Docking of targeting-competent mature domains requires that their extensive disorder is finely tuned...
June 5, 2017: Structure
https://www.readbyqxmd.com/read/28623593/boolean-dynamic-modeling-approaches-to-study-plant-gene-regulatory-networks-integration-validation-and-prediction
#7
José Dávila Velderraín, Juan Carlos Martínez-García, Elena R Álvarez-Buylla
Mathematical models based on dynamical systems theory are well-suited tools for the integration of available molecular experimental data into coherent frameworks in order to propose hypotheses about the cooperative regulatory mechanisms driving developmental processes. Computational analysis of the proposed models using well-established methods enables testing the hypotheses by contrasting predictions with observations. Within such framework, Boolean gene regulatory network dynamical models have been extensively used in modeling plant development...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28616148/the-structural-assembly-switch-of-cell-division-protein-ftsz-probed-with-fluorescent-allosteric-inhibitors
#8
Marta Artola, Laura B Ruíz-Avila, Erney Ramírez-Aportela, R Fernando Martínez, Lidia Araujo-Bazán, Henar Vázquez-Villa, Mar Martín-Fontecha, María A Oliva, A Javier Martín-Galiano, Pablo Chacón, María L López-Rodríguez, José M Andreu, Sonia Huecas
FtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching between inactive and actively associating monomer conformations. The structural switch mechanism was proposed to involve a movement of the C-terminal and N-terminal FtsZ domains, opening a cleft between them, allosterically coupled to the formation of a tight association interface between consecutive subunits along the filament...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28609127/finding-closure-continuing-bonds-and-codentification-after-the-9-11-attacks
#9
Victor Toom
In this article, I'm interested in the 2,750 victims of the 9/11 attacks in New York City. I consider two connected issues. The first regards bereavement journeys of victims' families and the significance of receiving a body to bury vis-à-vis the normative assignment to find closure. The second issue I address is how forensic experts, their technologies and managing protocols interact with victims' families and their emotions. Using insights from Science and Technology Studies, I articulate some of the goods and bads of identification practices, and argue for extensive communication and cooperation between experts and victims' families...
June 13, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28603057/prevalence-of-eosinophilic-gastroenteritis-and-colitis-in-a-population-based-study-from-2012-to-2017
#10
Emad Mansoor, Mohannad Abou Saleh, Gregory S Cooper
BACKGROUND & AIMS: Although eosinophilic esophagitis (EoE) has been extensively studied, there have been few epidemiology studies of other eosinophilic gastrointestinal disorders (EGIDs). Using a large, population-based database, we investigated epidemiologic features of eosinophilic gastroenteritis (EoGE), and colitis (EoC) in the United States (US). METHODS: We collected data from a commercial database (Explorys Inc, Cleveland, OH) that provided electronic health records from 26 major integrated US healthcare systems from 1999 to March 2017...
June 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28601895/site-saturation-mutagenesis-library-construction-and-screening-for-specific-broad-spectrum-single-domain-antibodies-against-multiple-cry1-toxins
#11
Lingxia Jiao, Yuan Liu, Xiao Zhang, Beibei Liu, Cunzheng Zhang, Xianjin Liu
Potential ecological environmental and food safety risks of various Cry toxins of Bacillus thuringiensis (Bt) in transgenic food have received gradually increasing attention, which urged to establish an efficient and broad-spectrum detection technology for Cry toxins. Based on the single-domain antibody (sdAb) A8 against Bt Cry1Ab toxin screened from the humanized domain antibody library, the key amino acids of sdAb (A8) binding five kinds of Cry1 toxins were predicted using homology modeling and molecular docking technology, and the results showed that 105th asparagine, 106th arginine, 107th valine, and 114th arginine, respectively, located in heavy-chain complementarity-determining region 3 were common key amino acid sites...
June 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28595322/the-effects-of-bit-wear-on-respirable-silica-dust-noise-and-productivity-a-hammer-drill-bench-study
#12
Paul Carty, Michael R Cooper, Alan Barr, Richard L Neitzel, John Balmes, David Rempel
Objectives: Hammer drills are used extensively in commercial construction for drilling into concrete for tasks including rebar installation for structural upgrades and anchor bolt installation. This drilling task can expose workers to respirable silica dust and noise. The aim of this pilot study was to evaluate the effects of bit wear on respirable silica dust, noise, and drilling productivity. Method: Test bits were worn to three states by drilling consecutive holes to different cumulative drilling depths: 0, 780, and 1560 cm...
June 8, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28566814/endocrine-responses-and-acute-mtor-pathway-phosphorylation-to-resistance-exercise-with-leucine-and-whey
#13
M T Lane, T J Herda, A C Fry, M A Cooper, M J Andre, P M Gallagher
Leucine ingestion reportedly activates the mTOR pathway in skeletal muscle, contributing to a hypertrophy response. The purpose of the study was to compare the post-resistance exercise effects of leucine and whey protein supplementation on endocrine responses and muscle mTOR pathway phosphorylation. On visit 1, subjects (X±SD; n=20; age=27.8±2.8yrs) provided baseline blood samples for analysis of cortisol, glucose and insulin; a muscle biopsy of the vastus lateralis muscle to assess mTOR signaling pathway phosphorylation; and were tested for maximum strength on the leg press and leg extension exercises...
June 2017: Biology of Sport
https://www.readbyqxmd.com/read/28561856/la-iii-biodistribution-profiles-from-intravenous-and-oral-dosing-of-two-lanthanum-complexes-la-dpp-3-and-la-xt-and-evaluation-as-treatments-for-bone-resorption-disorders
#14
D M Weekes, J F Cawthray, M Rieder, J Syeda, M Ali, E Wasan, T I Kostelnik, B O Patrick, A Panahifar, A Al-Dissi, D Cooper, K M Wasan, C Orvig
Trivalent lanthanum (La(3+)) has the potential to treat bone resorption disorders (such as osteoporosis) by eliciting a bone-building response in the cells which control skeletal remodelling. Because La(3+) suffers from extremely poor intestinal absorption, specifically designed chelators are required in order that a biologically active form of lanthanum can be administered orally. Two such chelators, 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdpp) and bis-{[bis(carboxymethyl)amino]methy}phosphinic acid (H5XT), have previously been the subjects of extensive physical, in vitro, and in vivo testing as the tris- and mono-lanthanum(iii) complexes La(dpp)3 and La(XT), respectively...
May 31, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28561593/ionothermal-design-of-crystalline-halogeno-cyano-cuprate-family-structure-diversity-solid-state-luminescence-and-photocatalytic-performance
#15
Ya-Li Zhang, Rui Ding, Shu-Ni Li, Yu-Cheng Jiang, Man-Cheng Hu, Quan-Guo Zhai
A general preparative method for multifunctional halogeno(cyano)cuprate materials in ionic liquids is developed in this work. Under ionothermal conditions, alkylimidazolium-based ionic liquids serving as solvent, charge-compensating, and structure-directing agent, as well as reactant lead to 12 members of the novel hybrid halogeno(cyano)cuprate family with a general formula of [R1R2R3IM]b+c-a[CuaXb(CN)c] (R1R2R3IM = alkylimidazolium cations, X = halide anions). X-ray single-crystal diffractions show that diverse inorganic halogeno(cyano)cuprate components vary from discrete complexes (1 and 2), one-dimensional (1D) chains (3-7), two-dimensional (2D) layer (8), to three-dimensional (3D) open frameworks (9-12)...
May 31, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28558249/reaction-mechanism-of-cu-i-mediated-reductive-co2-coupling-for-the-selective-formation-of-oxalate-cooperative-co2-reduction-to-give-mixed-valence-cu2-co2-%C3%A2-and-nucleophilic-like-attack
#16
Jialing Lan, Tao Liao, Tonghuan Zhang, Lung Wa Chung
A dinuclear, Cu(I)-catalyzed reductive CO2 coupling reaction was recently developed to selectively yield a metal-oxalate product through electrochemical means, instead of the usual formation of carbonate and CO ( Science 2010 , 327 , 313 ). To shed light on the mechanism of this important and unusual reductive coupling reaction, extensive and systematic density functional theory (DFT) calculations on several possible pathways and spin states were performed in which a realistic system up to 164 atoms was adopted...
May 30, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28536141/melk-and-ezh2-cooperate-to-regulate-medulloblastoma-cancer-stem-like-cell-proliferation-and-differentiation
#17
Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang, Hongyu Yuan, Shuhuan Pang, Xueling Qi, Haoran Wang, Mingshan Zhang, Hongwei Zhang, Chunjiang Yu, Chunyu Gu
Medulloblastoma is the most common malignant brain tumor in children. Although accumulated research has suggested that cancer stem-like cells play a key role in medulloblastoma tumorigenesis, the specific molecular mechanism regarding proliferation remains elusive. Here, we reported more abundant expression of maternal embryonic leucine-zipper kinase (MELK) and enhancer of zeste homolog 2 (EZH2) in medulloblastoma stem-like cells than in neural stem cells and the interaction between the two proteins could mediate the self-renewal of sonic hedgehog subtype medulloblastoma...
May 23, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28526794/raffinose-induces-biofilm-formation-by-streptococcus-mutans-in-low-concentrations-of-sucrose-by-increasing-production-of-extracellular-dna-and-fructan
#18
Ryo Nagasawa, Tsutomu Sato, Hidenobu Senpuku
Streptococcus mutans is the primary etiological agent of dental caries and causes tooth decay by forming a firmly attached biofilm on tooth surfaces. Biofilm formation is induced by the presence of sucrose, which is a substrate for the synthesis of extracellular polysaccharides, but not in the presence of oligosaccharides. Nonetheless, in this study, we found that raffinose, which is an oligosaccharide with an intestinal regulatory function and antiallergic effect, induced biofilm formation by S. mutans in a mixed culture with sucrose which was at concentrations less than those required to induce biofilm formation directly...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28517011/dissection-of-h-bonding-interactions-in-a-glycolic-acid-water-dimer
#19
Quanli Gu, Dan Shen, Zhen Tang, Wei Wu, Peifeng Su, Yong Xia, Zhijun Yang, Carl O Trindle
The binding strength and collective effects of multiple H-bonds in the glycolic acid-water dimer were studied in comparison to the aromatic analog, 9-hydroxy-9-fluorene carboxylic acid (9HFCA). Quantitative analysis by the generalized Kohn-Sham energy decomposition analysis shows that the energy difference in each specific physical interaction, from a glycolic acid-water dimer to a 9HFCA-water dimer, is small and amounts to less than 5% of the binding energy of the 9HFCA-water dimer. Extensive comparison of further, similar H-bonded complexes with widely varying binding strengths reinforces their excellent analogy in that the fluorene group acts as a non-interfering spectator for intermolecular H-bonding interactions...
June 7, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28515971/prediction-of-functional-movement-screen%C3%A2-performance-from-lower-extremity-range-of-motion-and-core-tests
#20
Nicole J Chimera, Shelby Knoeller, Ron Cooper, Nicholas Kothe, Craig Smith, Meghan Warren
BACKGROUND: There are varied reports in the literature regarding the association of the Functional Movement Screen™ (FMS™) with injury. The FMS™ has been correlated with hamstring range of motion and plank hold times; however, limited research is available on the predictability of lower extremity range of motion (ROM) and core function on FMS™ performance. PURPOSE/HYPOTHESES: The purpose of this study was to examine whether active lower extremity ROM measurements and core functional tests predict FMS™ performance...
April 2017: International Journal of Sports Physical Therapy
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