keyword
MENU ▼
Read by QxMD icon Read
search

preeclampsia etiology

keyword
https://www.readbyqxmd.com/read/29599749/mir-518b-enhances-human-trophoblast-cell-proliferation-through-targeting-rap1b-and-activating-ras-mapk-signal
#1
Ming Liu, Yongqing Wang, Huifen Lu, Hao Wang, Xiaoming Shi, Xuan Shao, Yu-Xia Li, Yangyu Zhao, Yan-Ling Wang
Preeclampsia is a pregnancy-specific complication defined as newly onset gestational hypertension and proteinuria. Deficiency in placental development is considered as the predominant cause of preeclampsia. Our previous study found that the expression of miR-518b increased significantly in the preeclamptic placentas, indicating the potential participation of this small RNA in the occurrence of preeclampsia. In this study, data analysis using multiple databases predicted Rap1b as a candidate target of miR-518b...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29568173/maternal-periodontal-disease-and-preeclampsia-in-jaipur-population
#2
Girija Jaiman, Prathibha Anand Nayak, Sanu Sharma, Kiran Nagpal
Background: Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Hence, an attempt has been made in this study to evaluate the relationship between the preeclampsia and maternal periodontal disease. Materials and Methods: The case-control study comprised of thirty pregnant women distributed equally in the case (preeclampsia) and control (healthy) group...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29564260/seasonal-variation-in-the-prevalence-of-preeclampsia
#3
Fatemeh Janani, Farahnaz Changaee
Introduction: Hypertension in pregnancy is one of the three factors of maternal mortality. Etiology of the disease is unknown, but the many factors contributing to the identification and control of it can be taken a step to prevent and reduce the symptoms of the disease. The purpose of this study was to determine the prevalence of preeclampsia (high-blood pressure) in different seasons of the year. Methods: The present retrospective cross-sectional study was conducted on more than 8,000 pregnant women visiting Assali specialized hospital from 2011 to 2013...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29544467/delayed-lactogenesis-ii-and-potential-utility-of-antenatal-milk-expression-in-women-developing-late-onset-preeclampsia-a-case-series
#4
Jill Demirci, Mandy Schmella, Melissa Glasser, Lisa Bodnar, Katherine P Himes
BACKGROUND: Preeclampsia is a multi-system, hypertensive disorder of pregnancy that increases a woman's risk of later-life cardiovascular disease. Breastfeeding may counteract the negative cardiovascular sequela associated with preeclampsia; however, women who develop preeclampsia may be at-risk for suboptimal breastfeeding rates. In this case series, we present three cases of late-onset preeclampsia and one case of severe gestational hypertension that illustrate a potential association between hypertensive disorders of pregnancy and suboptimal breastfeeding outcomes, including delayed onset of lactogenesis II and in-hospital formula supplementation...
March 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29521599/celecoxib-restores-angiogenic-factor-expression-at-the-maternal-fetal-interface-in-the-bph-5-mouse-model-of-preeclampsia
#5
Dorien Reijnders, Chin-Chi Liu, Xinjing Xu, Anna Zhao, Kelsey Olson, Scott D Butler, Nataki C Douglas, Jenny L Sones
Preeclampsia (PE), a hypertensive disease of pregnancy, is a leading cause of fetal and maternal morbidity/mortality. Early angiogenic and inflammatory disturbances within the placenta are thought to underlie the development of the maternal PE syndrome and poor pregnancy outcomes. However, the exact etiology remains largely unknown. Here, we use the BPH/5 mouse model of PE to elucidate the way in which inflammation early in pregnancy contributes to abnormal expression of angiogenic factors at the maternal-fetal interface...
March 9, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29519542/point-of-care-fecal-calprotectin-monitoring-in-preterm-infants-at-risk-for-necrotizing-enterocolitis
#6
Warapan Nakayuenyongsuk, Megan Christofferson, David K Stevenson, Karl Sylvester, Henry C Lee, K T Park
OBJECTIVE: To establish baseline trends in fecal calprotectin, a protein excreted into the stool when there is neutrophilic inflammation in the bowel, in infants at risk for necrotizing enterocolitis (NEC). STUDY DESIGN: We performed a prospective observational cohort study in infants with a birth weight of <1500 g without existing bowel disease at a level IV neonatal intensive care unit from October 2015 to September 2016. Stools were collected once daily for 30 days or until 32 weeks postmenstrual age and processed using the Fecal Calprotectin High Range Quantitative Quantum Blue assay...
March 6, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29473285/angiogenic-factors-in-preeclampsia-implications-for-clinical-practice
#7
S Ananth Karumanchi
More than a decade ago, circulating anti-angiogenic factors of placental origin were implicated in the pathogenesis of preeclampsia (Karumanchi SA. Hypertension. 2016 Jun;67(6):1072-9). In particular, circulating soluble fms-like tyrosine kinase 1 (sFlt-1), an anti-angiogenic factor that inhibits vascular endothelial growth factor (VEGF) signaling has been extensively studied in humans and in animal models of preeclampsia. Epidemiological, experimental and genetic studies point to a causal role for sFlt1 in the etiology of the disease...
February 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29463626/maternal-and-paternal-height-and-the-risk-of-preeclampsia
#8
Yunsung Lee, Per Magnus
The etiology of preeclampsia is unknown. Tall women have been found to have lower incidence of preeclampsia. This points to a possible biological causal effect but may be because of socioeconomic confounding. We used paternal height as an unexposed control to examine confounding. The MoBa (Norwegian Mother and Child Cohort Study) was used to extract data on parental heights, maternal prepregnancy weight, other background factors, and pregnancy outcomes for 99 968 singleton births. Multiple logistic regression was used to estimate odds ratios for preeclampsia according to parental height...
April 2018: Hypertension
https://www.readbyqxmd.com/read/29446070/a-hospital-based-retrospective-study-of-acute-postpartum-headache
#9
Angeliki Vgontzas, Matthew S Robbins
OBJECTIVE: To describe acute headache diagnoses in women presenting emergently in the postpartum period and to determine which factors may be associated with secondary vs primary headache. BACKGROUND: Hormonal, vascular, and procedural factors elevate the risk for both secondary and primary headache disorders in the postpartum period. Differentiating between these can be a diagnostic challenge, particularly among the most severe patients referred for urgent neurological consultation...
February 15, 2018: Headache
https://www.readbyqxmd.com/read/29415560/current-model-systems-for-the-study-of-preeclampsia
#10
M L Martinez-Fierro, G P Hernández-Delgadillo, V Flores-Morales, E Cardenas-Vargas, M Mercado-Reyes, I P Rodriguez-Sanchez, I Delgado-Enciso, C E Galván-Tejada, J I Galván-Tejada, J M Celaya-Padilla, I Garza-Veloz
Preeclampsia (PE) is a pregnancy complex disease, distinguished by high blood pressure and proteinuria, diagnosed after the 20th gestation week. Depending on the values of blood pressure, urine protein concentrations, symptomatology, and onset of disease there is a wide range of phenotypes, from mild forms developing predominantly at the end of pregnancy to severe forms developing in the early stage of pregnancy. In the worst cases severe forms of PE could lead to systemic endothelial dysfunction, eclampsia, and maternal and/or fetal death...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29279353/angiogenic-factor-imbalance-precedes-complement-deposition-in-placentae-of-the-bph-5-model-of-preeclampsia
#11
Jennifer L Sones, Audrey A Merriam, Angelina Seffens, Dex-Ann Brown-Grant, Scott D Butler, Anna M Zhao, Xinjing Xu, Carrie J Shawber, Jennifer K Grenier, Nataki C Douglas
Preeclampsia (PE), a hypertensive disorder of pregnancy, is a leading cause of maternal and fetal morbidity and mortality. Although the etiology is unknown, PE is thought to be caused by defective implantation and decidualization in pregnancy. Pregnant blood pressure high (BPH)/5 mice spontaneously develop placentopathies and maternal features of human PE. We hypothesized that BPH/5 implantation sites have transcriptomic alterations. Next-generation RNA sequencing of implantation sites at peak decidualization, embryonic day (E)7...
January 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29273682/downregulation-of-decidual-sp1-and-p300-is-associated-with-severe-preeclampsia
#12
Yachao Zhang, Jieqiong Yang, Shijian Lv, Dong-Qin Zhao, Zi-Jiang Chen, Wei-Ping Li, Cong Zhang
Preeclampsia (PE) is a pregnancy-induced disorder characterized by hypertension and proteinuria after 20 weeks of gestation, affecting 5-7% of pregnancies worldwide. So far, the etiology of PE remains poorly understood. Abnormal decidualization is thought to contribute to the development of PE. SP1 belongs to the Sp/KLF superfamily and can recruit P300 to regulate the transcription of several genes. SP1 is also very important for decidualization as it enhances the expression of tissue factor. In this study, we investigated the expression of SP1 and P300 in deciduae and their relationship with PE...
February 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29212809/animal-models-of-preeclampsia-translational-failings-and-why
#13
Sarah A Marshall, Natalie J Hannan, Maria Jelinic, Thy P H Nguyen, Jane E Girling, Laura J Parry
Preeclampsia affects up to 8% of pregnancies worldwide and is a leading cause of both maternal and fetal morbidity and mortality. Our current understanding of the cause(s) of preeclampsia is far from complete, and the lack of a single reliable animal model that recapitulates all aspects of the disease further confounds our understanding. This is partially due to the heterogeneous nature of the disease, coupled with our evolving understanding of its etiology. Nevertheless, animal models are still highly relevant and useful tools that help us better understand the pathophysiology of specific aspects of preeclampsia...
December 6, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29196995/epigenetics-and-preeclampsia-programming-of-future-outcomes
#14
Alberto Borges Peixoto, Liliam Cristine Rolo, Luciano Marcondes Machado Nardozza, Edward Araujo Júnior
Pregnancy is known to induce rapid, progressive, and substantial changes to the cardiovascular system, ultimately facilitating successful pregnancy outcomes. Women who develop hypertensive disorders during pregnancy are considered to have "failed" the cardiovascular stress test of pregnancy and likely represent a subpopulation with inadequate cardiovascular accommodation. Preeclampsia is a serious complication with a myriad of manifestations in both mother and offspring. This pregnancy syndrome is a polygenic disease and has now been linked to a greater incidence of cardiovascular disease...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29193660/preterm-birth-with-placental-evidence-of-malperfusion-is-associated-with-cardiovascular-risk-factors-after-pregnancy-a-prospective-cohort-study
#15
J M Catov, M F Muldoon, S E Reis, R B Ness, L N Nguyen, J-M Yamal, H Hwang, W T Parks
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. DESIGN: Pregnancy cohort study. SETTING: Pittsburgh, PA, USA. POPULATION: Women with PTB (n = 115) and term births (n = 210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers were compared in women with prior PTB versus term births; pre-eclampsia and growth restriction cases were excluded...
November 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29184401/placenta-derived-exosomes-potential-biomarkers-of-preeclampsia
#16
REVIEW
Preenan Pillay, Kogi Moodley, Jagidesa Moodley, Irene Mackraj
Preeclampsia remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the lack of clarity on the etiology of the disorder. Although several clinical and biological markers of preeclampsia have been evaluated, they have proven to be ineffective in providing a definitive diagnosis during the various stages of the disorder. Exosomes have emerged as ideal biomarkers of pathological states, such as cancer, and have more recently gained interest in pregnancy-related complications, due to their role in cellular communication in normal and complicated pregnancies...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29163791/abnormal-cyp11a1-gene-expression-induces-excessive-autophagy-contributing-to-the-pathogenesis-of-preeclampsia
#17
Tianying Pan, Guolin He, Meng Chen, Chenyi Bao, Yan Chen, Guangyu Liu, Mi Zhou, Shuying Li, Wenming Xu, Xinghui Liu
Objective: In this study, we investigated the exact mechanism by which excessive CYP11A1 expression impairs the placentation process and whether this causes preeclampsia (PE) in an in vivo model. Setting and Design: In order to study CYP11A1 overexpression, BeWo cells were transfected with CYP11A1. Pregnenolone, progesterone, and testosterone levels were measured by enzyme linked immunosorbent assays, and levels of autophagy markers were quantified by western blotting and immunofluorescence...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29153697/increased-tissue-factor-expression-and-promoter-hypomethylation-in-preeclampsia-placentas-in-a-chinese-population
#18
Rui Liu, Qiang Ma, Anxin Wen, Gaiyan Tian, Meili Li, Wenjuan Wang, Weimin Wang
OBJECTIVES: To explore the relationship between expression of tissue factor and its methylation levels in the placentas of preeclampsia among Chinese Han population. METHODS: In this study, we explored gene manifestation or expression of tissue factor, and evaluated methylation levels of tissue factor promoter areas in 16 clinical preeclampsia placentas as well as 16 paired normal pregnancy placentas from the Chinese Han population. Real-time PCR, immunohistochemistry, Western blotting, and methylation-specific PCR were conducted...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29113524/how-does-preeclampsia-affect-neonates-highlights-in-the-disease-s-immunity
#19
Lina R Marins, Leonardo B Anizelli, Mariana D Romanowski, Ana L Sarquis
INTRODUCTION: Preeclampsia (PE) is the primary obstetrical cause in one of the four perinatal deaths. Although the etiology and pathogenesis of preeclampsia is not fully known, a proinflammatory immune state prevails and can disrupt fetal hematopoiesis. Some of the effects on the newborn include neonatal thrombocytopenia, neutropenia, a reduction in T regulatory cells, and an increased cytotoxic natural killer cell profile. METHODS: Electronic databases were searched, and defined criteria were applied to select articles for review...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29092665/the-agonistic-autoantibodies-to-the-angiotensin-ii-type-1-receptor-in-pregnancies-complicated-by-hypertensive-disorders
#20
Agata Szpera-Gozdziewicz, Tomasz Gozdziewicz, Przemysław Wirstlein, Ewa Wender-Ozegowska, Grzegorz H Breborowicz
INTRODUCTION: The etiology and pathogenesis of pregnancy-related hypertensive disorders is complex and multifactorial. The aim of our study is the investigation of the differences in the autoantibodies against angiotensin II type 1 receptor (AT1-AA) titers among pregnant patients with chronic hypertension, gestational hypertension and preeclampsia compared to the healthy pregnant women. PATIENTS AND METHODS: We created 3 study groups (preeclampsia [n = 16], chronic hypertension [n = 13], gestational hypertension [n = 17]) and the control group consisting of 17 healthy pregnant women...
November 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
keyword
keyword
118365
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"