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preeclampsia etiology

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https://www.readbyqxmd.com/read/29892919/resistant-hypertension-in-pregnancy-how-to-manage
#1
REVIEW
Maria Rita Bortolotto, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib
PURPOSE OF REVIEW: The concept of resistant hypertension may be changed during pregnancy by the physiological hemodynamic changes and the particularities of therapy choices in this period. This review discusses the management of pregnant patients with preexisting resistant hypertension and also of those who develop severe hypertension in gestation and puerperium. RECENT FINDINGS: The main cause of severe hypertension in pregnancy is preeclampsia, and differential diagnosis must be done with secondary or primary hypertension...
June 11, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29861567/collapsing-glomerulopathy-and-thrombotic-microangiopathy-in-postpartum-period-two-case-reports
#2
N Gopalakrishnan, J Dhanapriya, C Padmakumar, T Dineshkumar, A A Kurien, R Sakthirajan, T Balasubramaniyan
Collapsing glomerulopathy (CG) is a distinct histopathologic pattern of glomerular injury characterized by global/segmental wrinkling of the glomerular basement membrane with podocyte hyperplasia and hypertrophy along with tubulointerstitial changes. There is no specific treatment for CG due to etiological heterogeneity, and newer insights into the pathogenesis may lead to the development of targeted therapy. The most common form of CG is the primary or idiopathic followed by secondary (due to viral infections, autoimmune disease, drugs, etc...
March 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29792056/placenta-in-intrauterine-fetal-demise-iufd-a-comprehensive-study-from-a-tertiary-care-hospital
#3
Anisha Manocha, Gayatri Ravikumar, Julian Crasta
BACKGROUND: Intrauterine fetal demise (IUFD) is an unpredictable and challenging obstetric complication. Its etiology is multifactorial with more than 60% attributed to the placental cause. The present study was done with a primary objective of understanding the placental lesions underlying IUFD. METHODS: In this retrospective observational study, IUFD cases (> 22 weeks) between January 2012-September 2015 were collected from pathology database. The clinical details with ultrasound findings were collected from mother's charts...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29750965/a-tag-snp-in-syncytin-2-3-utr-significantly-correlates-with-the-risk-of-severe-preeclampsia
#4
Ying Hua, Jing Wang, Dong-Lan Yuan, Yaozhi Qi, Zuoqing Tang, Xueqiong Zhu, Shi-Wen Jiang
BACKGROUND: Preeclampsia is a disease that frequently complicates pregnancy and poses a serious threat to maternal and fetal health. The causes and pathogenic mechanisms of preeclampsia are poorly defined. Genetic predisposition could be an important etiological factor. Previous studies have demonstrated that syncytin-1 and syncytin-2, encoded by the genes ERVWE1 and ERVFRDE-1, are involved in the pathogenesis of preeclampsia. METHODS: In this study, we applied multiplex PCR and MALDI-TOF MS techniques to analyze six selected tag SNPs of ERVWE1 and ERVFRDE-1 in 120 preeclampsia patients and 181 normal controls...
May 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29737528/preterm-delivery-is-associated-with-an-increased-risk-of-epithelial-ovarian-cancer-among-parous-women
#5
Camilla Sköld, Tone Bjørge, Anders Ekbom, Anders Engeland, Mika Gissler, Tom Grotmol, Laura Madanat, Anne Gulbech Ording, Olof Stephansson, Britton Trabert, Steinar Tretli, Rebecca Troisi, Henrik Toft Sørensen, Ingrid Glimelius
Epithelial ovarian cancer is a fatal disease of largely unknown etiology. Higher parity is associated with reduced risk of ovarian cancer. However, among parous women, the impact of pregnancy-related factors on risk is not well understood. This population-based case-control study included all parous women with epithelial ovarian cancer in Denmark, Finland, Norway and Sweden during 1967-2013 (n=10,957) and up to 10 matched controls (n=107,864). We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for pregnancy-related factors and ovarian cancer risk by histological subtype...
May 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29725629/acute-kidney-injury-in-pregnancy-the-changing-landscape-for-the-21st-century
#6
REVIEW
Swati Rao, Belinda Jim
Pregnancy-related acute kidney injury (Pr-AKI) remains a large public health problem, with decreasing incidences in developing countries but seemingly increasing incidences in the United States and Canada. These epidemiologic changes are reflective of the advances in medical and obstetric care, as well as changes in underlying maternal risk factors. The risk factors associated with advanced maternal age, such as hypertension, diabetes, chronic kidney disease, and those associated with reproductive technologies such as multiple gestations, are increasing...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29718786/association-between-serum-ca125-levels-in-preeclampsia-and-its-severity-among-women-in-lagos-south-west-nigeria
#7
Gbemisola E Osanyin, Kehinde S Okunade, Ayodeji Ayotunde Oluwole
BACKGROUND: Preeclampsia is a syndrome of unknown etiology characterized by hypertension, proteinuria, and/or organ dysfunction. CA125 is an antigenic determinant recognized by the murine monoclonal antibody OC125 quantified by radioimmunoassay. Its role in obstetrics is yet to be fully understood as most clinical trials advocating its uses are widely experimental in nature and unacknowledged. AIM: This study was done to assess the relationship between serum concentration of CA125 in normal pregnancies and those complicated with preeclampsia...
May 2018: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29701150/the-critical-role-of-abnormal-trophoblast-development-in-the-etiology-of-preeclampsia
#8
Berthold Huppertz
BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of maternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus disease and with or without additional fetal growth restriction...
April 26, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29698330/inflammatory-markers-and-preeclampsia-a-systematic-review
#9
Kathleen Darrah Black, June Andrews Horowitz
BACKGROUND: Preeclampsia (PE), a serious and variable pregnancy complication affecting 5%-10% of the obstetric population, has an undetermined etiology, yet inflammation is concomitant with its development, particularly in relation to endothelial dysfunction. OBJECTIVE: The purpose of this systematic review was to examine the published evidence concerning an association between PE and inflammatory markers for their usefulness in the prediction or early identification of women with PE in antepartum clinical settings...
May 2018: Nursing Research
https://www.readbyqxmd.com/read/29599749/mir-518b-enhances-human-trophoblast-cell-proliferation-through-targeting-rap1b-and-activating-ras-mapk-signal
#10
Ming Liu, Yongqing Wang, Huifen Lu, Hao Wang, Xiaoming Shi, Xuan Shao, Yu-Xia Li, Yangyu Zhao, Yan-Ling Wang
Preeclampsia is a pregnancy-specific complication defined as newly onset gestational hypertension and proteinuria. Deficiency in placental development is considered as the predominant cause of preeclampsia. Our previous study found that the expression of miR-518b increased significantly in the preeclamptic placentas, indicating the potential participation of this small RNA in the occurrence of preeclampsia. In this study, data analysis using multiple databases predicted Rap1b as a candidate target of miR-518b...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29568173/maternal-periodontal-disease-and-preeclampsia-in-jaipur-population
#11
Girija Jaiman, Prathibha Anand Nayak, Sanu Sharma, Kiran Nagpal
Background: Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established. Hence, an attempt has been made in this study to evaluate the relationship between the preeclampsia and maternal periodontal disease. Materials and Methods: The case-control study comprised of thirty pregnant women distributed equally in the case (preeclampsia) and control (healthy) group...
January 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29564260/seasonal-variation-in-the-prevalence-of-preeclampsia
#12
Fatemeh Janani, Farahnaz Changaee
Introduction: Hypertension in pregnancy is one of the three factors of maternal mortality. Etiology of the disease is unknown, but the many factors contributing to the identification and control of it can be taken a step to prevent and reduce the symptoms of the disease. The purpose of this study was to determine the prevalence of preeclampsia (high-blood pressure) in different seasons of the year. Methods: The present retrospective cross-sectional study was conducted on more than 8,000 pregnant women visiting Assali specialized hospital from 2011 to 2013...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29544467/delayed-lactogenesis-ii-and-potential-utility-of-antenatal-milk-expression-in-women-developing-late-onset-preeclampsia-a-case-series
#13
Jill Demirci, Mandy Schmella, Melissa Glasser, Lisa Bodnar, Katherine P Himes
BACKGROUND: Preeclampsia is a multi-system, hypertensive disorder of pregnancy that increases a woman's risk of later-life cardiovascular disease. Breastfeeding may counteract the negative cardiovascular sequela associated with preeclampsia; however, women who develop preeclampsia may be at-risk for suboptimal breastfeeding rates. In this case series, we present three cases of late-onset preeclampsia and one case of severe gestational hypertension that illustrate a potential association between hypertensive disorders of pregnancy and suboptimal breastfeeding outcomes, including delayed onset of lactogenesis II and in-hospital formula supplementation...
March 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29521599/celecoxib-restores-angiogenic-factor-expression-at-the-maternal-fetal-interface-in-the-bph-5-mouse-model-of-preeclampsia
#14
Dorien Reijnders, Chin-Chi Liu, Xinjing Xu, Anna M Zhao, Kelsey N Olson, Scott D Butler, Nataki C Douglas, Jenny L Sones
Preeclampsia (PE), a hypertensive disease of pregnancy, is a leading cause of fetal and maternal morbidity/mortality. Early angiogenic and inflammatory disturbances within the placenta are thought to underlie the development of the maternal PE syndrome and poor pregnancy outcomes. However, the exact etiology remains largely unknown. Here, we use the BPH/5 mouse model of PE to elucidate the way in which inflammation early in pregnancy contributes to abnormal expression of angiogenic factors at the maternal-fetal interface...
May 1, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29519542/point-of-care-fecal-calprotectin-monitoring-in-preterm-infants-at-risk-for-necrotizing-enterocolitis
#15
Warapan Nakayuenyongsuk, Megan Christofferson, David K Stevenson, Karl Sylvester, Henry C Lee, K T Park
OBJECTIVE: To establish baseline trends in fecal calprotectin, a protein excreted into the stool when there is neutrophilic inflammation in the bowel, in infants at risk for necrotizing enterocolitis (NEC). STUDY DESIGN: We performed a prospective observational cohort study in infants with a birth weight of <1500 g without existing bowel disease at a level IV neonatal intensive care unit from October 2015 to September 2016. Stools were collected once daily for 30 days or until 32 weeks postmenstrual age and processed using the Fecal Calprotectin High Range Quantitative Quantum Blue assay...
May 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29473285/angiogenic-factors-in-pre-eclampsia-implications-for-clinical-practice
#16
S A Karumanchi
No abstract text is available yet for this article.
February 23, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29463626/maternal-and-paternal-height-and-the-risk-of-preeclampsia
#17
Yunsung Lee, Per Magnus
The etiology of preeclampsia is unknown. Tall women have been found to have lower incidence of preeclampsia. This points to a possible biological causal effect but may be because of socioeconomic confounding. We used paternal height as an unexposed control to examine confounding. The MoBa (Norwegian Mother and Child Cohort Study) was used to extract data on parental heights, maternal prepregnancy weight, other background factors, and pregnancy outcomes for 99 968 singleton births. Multiple logistic regression was used to estimate odds ratios for preeclampsia according to parental height...
April 2018: Hypertension
https://www.readbyqxmd.com/read/29446070/a-hospital-based-retrospective-study-of-acute-postpartum-headache
#18
Angeliki Vgontzas, Matthew S Robbins
OBJECTIVE: To describe acute headache diagnoses in women presenting emergently in the postpartum period and to determine which factors may be associated with secondary vs primary headache. BACKGROUND: Hormonal, vascular, and procedural factors elevate the risk for both secondary and primary headache disorders in the postpartum period. Differentiating between these can be a diagnostic challenge, particularly among the most severe patients referred for urgent neurological consultation...
February 15, 2018: Headache
https://www.readbyqxmd.com/read/29415560/current-model-systems-for-the-study-of-preeclampsia
#19
M L Martinez-Fierro, G P Hernández-Delgadillo, V Flores-Morales, E Cardenas-Vargas, M Mercado-Reyes, I P Rodriguez-Sanchez, I Delgado-Enciso, C E Galván-Tejada, J I Galván-Tejada, J M Celaya-Padilla, I Garza-Veloz
Preeclampsia (PE) is a pregnancy complex disease, distinguished by high blood pressure and proteinuria, diagnosed after the 20th gestation week. Depending on the values of blood pressure, urine protein concentrations, symptomatology, and onset of disease there is a wide range of phenotypes, from mild forms developing predominantly at the end of pregnancy to severe forms developing in the early stage of pregnancy. In the worst cases severe forms of PE could lead to systemic endothelial dysfunction, eclampsia, and maternal and/or fetal death...
March 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29279353/angiogenic-factor-imbalance-precedes-complement-deposition-in-placentae-of-the-bph-5-model-of-preeclampsia
#20
Jennifer L Sones, Audrey A Merriam, Angelina Seffens, Dex-Ann Brown-Grant, Scott D Butler, Anna M Zhao, Xinjing Xu, Carrie J Shawber, Jennifer K Grenier, Nataki C Douglas
Preeclampsia (PE), a hypertensive disorder of pregnancy, is a leading cause of maternal and fetal morbidity and mortality. Although the etiology is unknown, PE is thought to be caused by defective implantation and decidualization in pregnancy. Pregnant blood pressure high (BPH)/5 mice spontaneously develop placentopathies and maternal features of human PE. We hypothesized that BPH/5 implantation sites have transcriptomic alterations. Next-generation RNA sequencing of implantation sites at peak decidualization, embryonic day (E)7...
May 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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