keyword
MENU ▼
Read by QxMD icon Read
search

Landmark trial

keyword
https://www.readbyqxmd.com/read/28533919/combination-therapy-for-inflammatory-bowel-disease
#1
REVIEW
Keith S Sultan, Joshua C Berkowitz, Sundas Khan
Biologic therapies such as infliximab and adalimumab have become mainstays of treatment for inflammatory bowel disease. Early studies suggested that combination therapy (CT) with infliximab and an immunomodulator drug such as azathioprine may help optimize biologic pharmacokinetics, minimize immunogenicity, and improve outcomes. The landmark SONIC trial in Crohn's disease and the UC SUCCESS trial in ulcerative colitis demonstrated CT with infliximab and azathioprine to be superior to monotherapy with either agent alone at inducing clinical remission in treatment naïve patients with moderate to severe disease...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28530119/update-in-sleep-disordered-breathing-2016
#2
Najib T Ayas, Luciano F Drager, Mary J Morrell, Vsevolod Y Polotsky
The field of sleep disordered breathing has continued to evolve with many important articles published in the last year. In this review, we have summarized some of the key articles relevant to sleep disordered breathing that have been published in the Journal and selected articles published elsewhere in the last year; these have included landmark randomized trials concerning sleep apnea treatment in the prevention of adverse cardiac outcomes, basic science and animal studies, genetic studies, and analyses of epidemiologic cohorts...
May 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28526516/comparing-the-effect-of-temporal-delay-on-the-availability-of-egocentric-and-allocentric-information-in-visual-search
#3
Keira Ball, Yan Birch, Alison Lane, Amanda Ellison, Thomas Schenk
Frames of reference play a central role in perceiving an object's location and reaching to pick that object up. It is thought that the ventral stream, believed to subserve vision for perception, utilises allocentric coding, while the dorsal stream, argued to be responsible for vision for action, primarily uses an egocentric reference frame. We have previously shown that egocentric representations can survive a delay; however, it is possible that in comparison to allocentric information, egocentric information decays more rapidly...
May 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28521892/achieving-a-maximally-tolerated-%C3%AE-blocker-dose-in-heart-failure-patients-is-there-room%C3%A2-for%C3%A2-improvement
#4
REVIEW
Ankeet S Bhatt, Adam D DeVore, Tracy A DeWald, Karl Swedberg, Robert J Mentz
Heart failure (HF) is associated with significant morbidity and mortality. Although initially thought to be harmful in HF, beta-adrenergic blockers (β-blockers) have consistently been shown to reduce mortality and HF hospitalization in chronic HF with reduced ejection fraction. Proposed mechanisms include neurohormonal blockade and heart rate reduction. A new therapeutic agent now exists to target further heart rate lowering in patients who have been stable on a "maximally tolerated β-blocker dose," but this definition and how to achieve it are incompletely understood...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28512049/space-occupying-tumor-bed-cysts-as-a-complication-of-modern-treatment-for-high-grade-glioma
#5
Thomas Beez, Sven Burgula, Marcel Kamp, Marion Rapp, Hans-Jakob Steiger, Michael Sabel
INTRODUCTION: Management of high grade glioma (HGG) was changed by recent landmark trials and is nowadays more proactive. However, aggressive treatment leads to hospitalization due to side effects. Space-occupying tumor bed cysts have been described, but not systematically assessed. We sought to analyze this complication in a contemporary HGG cohort. METHODS: A retrospective review of HGG patients treated between 2007 and 2013 was performed, patients with space-occupying tumor bed cysts were identified and their hospital notes reviewed for relevant variables...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28504533/cue-integration-in-spatial-search-for-jointly-learned-landmarks-but-not-for-separately-learned-landmarks
#6
Yu Du, Neil McMillan, Christopher R Madan, Marcia L Spetch, Weimin Mou
The authors investigated how humans use multiple landmarks to locate a goal. Participants searched for a hidden goal location along a line between 2 distinct landmarks on a computer screen. On baseline trials, the location of the landmarks and goal varied, but the distance between each of the landmarks and the goal was held constant, with 1 landmark always closer to the goal. In Experiment 1, some baseline trials provided both landmarks, and some provided only 1 landmark. On probe trials, both landmarks were shifted apart relative to the previously learned goal location...
May 15, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28497476/optimization-of-a-novel-large-field-of-view-distortion-phantom-for-mr-only-treatment-planning
#7
Ryan G Price, Robert A Knight, Ken-Pin Hwang, Ersin Bayram, Siamak P Nejad-Davarani, Carri K Glide-Hurst
PURPOSE: MR-only treatment planning requires images of high geometric fidelity, particularly for large fields of view (FOV). However, the availability of large FOV distortion phantoms with analysis software is currently limited. This work sought to optimize a modular distortion phantom to accommodate multiple bore configurations and implement distortion characterization in a widely implementable solution. METHOD AND MATERIALS: To determine candidate materials, 1...
May 12, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28492286/has-the-sprint-trial-introduced-a-new-blood-pressure-goal-in-hypertension
#8
REVIEW
Gema Ruiz-Hurtado, José R Banegas, Pantelis A Sarafidis, Massimo Volpe, Bryan Williams, Luis M Ruilope
SPRINT is the first randomized, controlled trial showing that a systolic blood-pressure goal of <120 mmHg can be attained with cardiovascular benefits in a select group of patients with hypertension and an elevated cardiovascular risk with different origins. Although the patient population with characteristics like those in SPRINT makes up only 20-30% of the total hypertensive population, SPRINT is a landmark study that highlights the need to consider lower blood- pressure goals in the treatment of hypertension...
May 11, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28491278/recent-advances-in-the-management-of-acute-ischemic-stroke
#9
REVIEW
Philip Chang, Shyam Prabhakaran
In recent years, several landmark trials have transformed acute ischemic stroke care. The most dramatic results from the field of acute endovascular intervention demonstrate unequivocal benefit for a select group of patients with moderate to severe deficits presenting within 7 hours from onset and with occlusions of proximal arteries in the anterior circulation. In addition, technological advances and workflow efficiencies have facilitated more rapid delivery of acute stroke interventions. This review provides an overview of recent advances in the management of acute ischemic stroke...
2017: F1000Research
https://www.readbyqxmd.com/read/28486682/do-different-maxillary-expansion-appliances-influence-the-outcomes-of-the-treatment
#10
Muteb Algharbi, Farhan Bazargani, Lillemor Dimberg
Background and objectives: There is no consensus in the literature regarding which rapid maxillary expansion (RME) design or activation rate benefits the patients the most. Therefore, the primary aim of this systematic review was to see whether there is a difference in the skeletal and dentoalveolar effects of different RME appliances in children and growing adolescents. The secondary aim was to see whether these effects are different when using different activation protocols for these appliances...
May 9, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28475671/dabrafenib-plus-trametinib-versus-dabrafenib-monotherapy-in-patients-with-metastatic-braf-v600e-k-mutant-melanoma-long-term-survival-and-safety-analysis-of-a-phase-3-study
#11
G V Long, K T Flaherty, D Stroyakovskiy, H Gogas, E Levchenko, F de Braud, J Larkin, C Garbe, T Jouary, A Hauschild, V Chiarion-Sileni, C Lebbe, M Mandalà, M Millward, A Arance, I Bondarenko, J B A G Haanen, J Hansson, J Utikal, V Ferraresi, P Mohr, V Probachai, D Schadendorf, P Nathan, C Robert, A Ribas, M A Davies, S R Lane, J J Legos, B Mookerjee, J-J Grob
Background: Previous analysis of COMBI-d (NCT01584648) demonstrated improved progression-free survival (PFS) and overall survival (OS) with combination dabrafenib and trametinib versus dabrafenib monotherapy in BRAF V600E/K-mutant metastatic melanoma. This study was continued to assess 3-year landmark efficacy and safety after ≥36-month follow-up for all living patients. Patients and methods: This double-blind, phase 3 study enrolled previously untreated patients with BRAF V600E/K-mutant unresectable stage IIIC or stage IV melanoma...
May 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28475383/fractional-flow-reserve-in-2017-current-data-and-everyday-practice
#12
J J Coughlan, Colin MacDonnell, Samer Arnous, Thomas J Kiernan
Fractional Flow Reserve (FFR) is an objective physiological index utilized in coronary angiography. It expresses the blood flow in the presence of a coronary artery stenosis as a fraction of the normal blood flow and gives information regarding the functional significance of the lesion. FFR guided percutaneous coronary intervention (PCI) has been shown to be superior to angiography guided PCI in several trials and registries. In addition, it appears that the use of FFR may also be preferable from an economic perspective...
May 5, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28475181/a-systematic-review-to-assess-the-treat-and-extend-dosing-regimen-for-neovascular-age-related-macular-degeneration-using-ranibizumab
#13
REVIEW
S R Rufai, H Almuhtaseb, R M Paul, B L Stuart, T Kendrick, H Lee, A J Lotery
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the developed world. Monthly or as-needed (PRN) dosing strategies of intravitreal ranibizumab have been established as efficacious treatment options for neovascular AMD. More recently, the 'treat-and-extend' dosing regimen (TREX) is being adopted in clinical practice as it represents a patient-centric and economical option, reducing treatment burden by extending injection intervals when possible. However, the efficacy of TREX using ranibizumab monotherapy remains to be defined...
May 5, 2017: Eye
https://www.readbyqxmd.com/read/28461255/improved-overall-survival-with-aggressive-primary-tumor-radiotherapy-for-patients-with-metastatic-esophageal-cancer
#14
David M Guttmann, Nandita Mitra, Justin Bekelman, James M Metz, John Plastaras, Weiwei Feng, Samuel Swisher-McClure
OBJECTIVES: The aim of this study was to characterize utilization and survival outcomes associated with primary tumor-directed radiotherapy (PTDRT) in patients with newly diagnosed metastatic esophageal cancer. METHODS: We conducted an observational cohort study using the National Cancer Data Base to evaluate patients with newly diagnosed metastatic esophageal cancer between 2004 and 2012. Overall survival outcomes after treatment with chemotherapy plus conventional palliative dose radiotherapy (<5040 cGy), chemotherapy plus definitive dose radiotherapy (≥5040 cGy), or chemotherapy alone were compared by using Cox proportional hazards models with inverse probability of treatment weighting using the propensity score...
April 28, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28454804/differential-occurrence-profile-and-impact-of-first-recurrent-cardiovascular-events-after-an-acute-coronary-syndrome
#15
Connie N Hess, Robert M Clare, Megan L Neely, Pierluigi Tricoci, Kenneth W Mahaffey, Stefan K James, John H Alexander, Claes Held, Renato D Lopes, Keith A A Fox, Harvey D White, Lars Wallentin, Paul W Armstrong, Robert A Harrington, Erik Magnus Ohman, Matthew T Roe
OBJECTIVE: Acute coronary syndrome (ACS) trials typically use a composite primary outcome (myocardial infarction [MI], stroke, or cardiovascular death), but differential patient characteristics, timing, and consequences associated with individual component end points as first events have not been well studied. We compared patient characteristics and prognostic significance associated with first cardiovascular events in the post-ACS setting for initially stabilized patients. METHODS: We combined patient-level data from 4 trials of post-ACS antithrombotic therapies (PLATO, APPRAISE-2, TRACER, and TRILOGY ACS) to characterize the timing of and characteristics associated with first cardiovascular events (MI, stroke, or cardiovascular death)...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28451610/changes-within-clinical-practice-after-a-randomized-controlled-trial-of-knee-arthroscopy-for-osteoarthritis
#16
Nirav H Amin, Waqas Hussain, John Ryan, Shannon Morrison, Anthony Miniaci, Morgan H Jones
BACKGROUND: In 2002, Moseley et al published a randomized controlled trial (RCT) that showed no difference between knee arthroscopy and placebo for patients with osteoarthritis (OA). We wanted to assess the impact of the trial on clinical practice in the United States. PURPOSE/HYPOTHESIS: To evaluate changes in knee arthroscopy practice before and after publication of the article by Moseley et al and to assess the effect of this landmark RCT on the behavior of practicing orthopaedic surgeons...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28441151/recent-clinical-trials-in-valvular-heart-disease
#17
Daniel Kiss, Saif Anwaruddin
PURPOSE OF REVIEW: With widespread adoption of transcatheter aortic valve replacement, there has been a change in the approach to management of valvular heart disease. New interest has taken hold in transcatheter therapies for valvular heart disease, as well as research into pathophysiology and progression of disease. Additionally, several key trials have further refined our understanding of surgical management of valvular heart disease. This review will elucidate recent clinical trial data leading to changes in practice...
April 24, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28436922/the-feasibility-of-manual-parameter-tuning-for-deformable-breast-mr-image-registration-from-a-multi-objective-optimization-perspective
#18
Kleopatra Pirpinia, Peter Bosman, Claudette Loo, Gonneke Winter-Warnars, Natasja Janssen, Astrid Scholten, Jan-Jakob Sonke, Marcel van Herk, Tanja Alderliesten
Deformable image registration is typically formulated as an optimization problem involving a linearly weighted combination of terms that correspond to objectives of interest (e.g., similarity, deformation magnitude). The weights, along with multiple other parameters, need to be manually tuned for each application, a task currently mainly addressed via trial-and-error approaches. Such approaches can only be successful if there is a sensible interplay between parameters, objectives, and desired registration outcome...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28427989/egocentric-and-allocentric-visuospatial-working-memory-in-premotor-huntington-s-disease-a-double-dissociation-with-caudate-and-hippocampal-volumes
#19
Katherine L Possin, Hosung Kim, Michael D Geschwind, Tacie Moskowitz, Erica T Johnson, Sharon J Sha, Alexandra Apple, Duan Xu, Bruce L Miller, Steven Finkbeiner, Christopher P Hess, Joel H Kramer
Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington's disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays...
April 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28416280/progress-toward-gene-therapy-for-duchenne-muscular-dystrophy
#20
REVIEW
Joel R Chamberlain, Jeffrey S Chamberlain
Duchenne muscular dystrophy (DMD) has been a major target for gene therapy development for nearly 30 years. DMD is among the most common genetic diseases, and isolation of the defective gene (DMD, or dystrophin) was a landmark discovery, as it was the first time a human disease gene had been cloned without knowledge of the protein product. Despite tremendous obstacles, including the enormous size of the gene and the large volume of muscle tissue in the human body, efforts to devise a treatment based on gene replacement have advanced steadily through the combined efforts of dozens of labs and patient advocacy groups...
May 3, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
keyword
keyword
11836
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"