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https://www.readbyqxmd.com/read/28925859/effects-of-evolocumab-on-cardiovascular-events
#1
Nasser Mikhail
BACKGROUND: Evolocumab is a potent lipid-lowering drug that decreases plasma levels of low-density lipoprotein cholesterol (LDL-C) by 50-60%. FOURIER is a landmark randomized, trial involving 27,564 patients with established cardiovascular disease already on statins and plasma LDL-C levels > 70 mg/dl. OBJECTIVE: the main objective of FOURIER was to examine the effects of evolocumab on cardiovascular events. RESULTS: After a mean follow-up of 2...
September 18, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28923101/durable-response-rate-as-an-endpoint-in-cancer-immunotherapy-insights-from-oncolytic-virus-clinical-trials
#2
Howard L Kaufman, Robert H I Andtbacka, Frances A Collichio, Michael Wolf, Zhongyun Zhao, Mark Shilkrut, Igor Puzanov, Merrick Ross
BACKGROUND: Traditional response criteria may be insufficient to characterize full clinical benefits of anticancer immunotherapies. Consequently, endpoints such as durable response rate (DRR; a continuous response [complete or partial objective response] beginning within 12 months of treatment and lasting ≥6 months) have been employed. There has not, however, been validation that DRR correlates with other more traditional endpoints of clinical benefit such as overall survival. METHODS: We evaluated whether DRR was associated with clinically meaningful measures of benefit (eg, overall survival [OS], quality of life [QoL], or treatment-free interval [TFI]) in a phase 3 clinical trial of an oncolytic virus for melanoma treatment...
September 19, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28922326/the-smile-index-part-1-a-large-scale-study-of-phenotypic-norms-for-pre-and-post-operative-unilateral-cleft-lip
#3
Caroline A Yao, Thomas Imahiyerobo, Jordan Swanson, Allyn Auslander, Diego De Cardenas, Jane C Figueiredo, Meghan McCullough, Melinda Costa, Richard Vanderburg, William P Magee
BACKGROUND: Unilateral cleft lip has a spectrum of disease morphology but severity assessments are difficult given the absence of an accessible, objective assessment tools or reference data. We characterize the spectrum of cleft morphology before and after surgical repair for a large, multi-ethnic population using easily identifiable facial landmarks collected through a novel smart phone-based application. METHODS: Anthropometric measurements and standardized photographs were prospectively collected in Morocco, Bolivia, Vietnam and Madagascar during medical missions in 2015 utilizing an application designed specifically for the study...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28917608/environmental-enrichment-in-the-absence-of-wheel-running-produces-beneficial-behavioural-and-anti-oxidative-effects-in-rats
#4
F Mármol, J Sánchez, M N Torres, V D Chamizo
The effects of early environmental enrichment (EE) when solving a simple spatial task in adult male rats were assessed. After weaning, rats were housed in pairs in enriched or standard cages (EE and control groups) for two and a half months. Then the rats were trained in a triangular-shaped pool to find a hidden platform whose location was defined in terms of two sources of information, a landmark outside the pool and a particular corner of the pool. As expected, enriched rats reached the platform faster than control animals...
September 13, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28911092/concurrent-and-sequential-initiation-of-ovarian-function-suppression-with-chemotherapy-in-premenopausal-women-with-endocrine-responsive-early-breast-cancer-an-exploratory-analysis-of-text-and-soft
#5
M M Regan, B A Walley, P A Francis, G F Fleming, I Láng, H L Gómez, M Colleoni, C Tondini, G Pinotti, M Salim, S Spazzapan, V Parmar, T Ruhstaller, E A Abdi, R D Gelber, A S Coates, A Goldhirsch, O Pagani
Background: Recent breast cancer treatment guidelines recommend that higher-risk premenopausal patients should receive ovarian function suppression (OFS) as part of adjuvant endocrine therapy. If chemotherapy is also given, it is uncertain whether to select concurrent or sequential OFS initiation. Design and methods: We analyzed 1872 patients enrolled in the randomized phase III TEXT and SOFT trials who received adjuvant chemotherapy for hormone receptor-positive, HER2-negative breast cancer and upon randomization to an OFS-containing adjuvant endocrine therapy, initiated gonadotropin-releasing-hormone-agonist triptorelin...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28910657/the-use-of-real-time-feedback-to-improve-kinematic-marker-placement-consistency-among-novice-examiners
#6
Charles A J Macaulay, Sean T Osis, Christian Clermont, Reed Ferber
Marker placement deviation has been shown to be the largest source of error in gait kinematic data, limiting the ability of clinicians and researchers to conduct between-day or between-center investigations. Prior marker-placement standardization methods are either impractical for a clinical setting or rely on expert marker placement. However, a recently developed, real-time feedback tool has been developed and shown to improve marker placement and downstream kinematic calculations. The purpose of this study was to determine whether this real-time marker-placement tool could improve the consistency of gait kinematic data collected by a group of novice examiners...
September 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28887893/trial-by-trial-co-variation-of-pre-stimulus-eeg-alpha-power-and-visuospatial-bias-reflects-a-mixture-of-stochastic-and-deterministic-effects
#7
Christopher S Y Benwell, Christian Keitel, Monika Harvey, Joachim Gross, Gregor Thut
Human perception of perithreshold stimuli critically depends on oscillatory EEG-activity prior to stimulus-onset. However, it remains unclear exactly which aspects of perception are shaped by this pre-stimulus activity and what role stochastic (trial-by-trial) variability plays in driving these relationships. We employed a novel Jackknife approach to link single-trial variability in oscillatory activity to psychometric measures from a task that requires judgement of the relative length of two line-segments (the landmark task)...
September 9, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28882235/efficacy-and-safety-of-ticagrelor-over%C3%A2-time-in-patients-with-prior-mi-in%C3%A2-pegasus-timi-54
#8
RANDOMIZED CONTROLLED TRIAL
Marc P Bonaca, Robert F Storey, Pierre Theroux, P Gabriel Steg, Deepak L Bhatt, Marc C Cohen, KyungAh Im, Sabina A Murphy, Giulia Magnani, Ton Oude Ophuis, Mikhail Rudah, Alexander Parkhomenko, Daniel Isaza, Gabriel Kamensky, Assen Goudev, Gilles Montalescot, Eva C Jensen, Per Johanson, Eugene Braunwald, Marc S Sabatine
BACKGROUND: Ticagrelor reduces ischemic risk in patients with prior myocardial infarction (MI). It remains unclear whether ischemic risk and the benefits of prolonged P2Y12 inhibition in this population remain consistent over time. OBJECTIVES: The study sought to investigate the pattern of ischemic risk over time and whether the efficacy and safety of ticagrelor were similar early and late after randomization. METHODS: The PEGASUS-TIMI (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis In Myocardial Infarction) 54 trial randomized patients with prior MI (median 1...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28878672/differences-in-spatial-memory-recognition-due-to-cognitive-style
#9
Laura Tascón, Maddalena Boccia, Laura Piccardi, José M Cimadevilla
Field independence refers to the ability to perceive details from the surrounding context as a whole and to represent the environment by relying on an internal reference frame. Conversely, field dependence individuals tend to focus their attention on single environmental features analysing them individually. This cognitive style affects several visuo-spatial abilities including spatial memory. This study assesses both the effect of field independence and field dependence on performance displayed on virtual environments of different complexity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28872329/sequential-effects-modulate-spatial-biases
#10
Dinis Gökaydin, Peter Brugger, Tobias Loetscher
Healthy individuals usually display a bias toward the left side of space. This effect can be measured in a line bisection task or, alternatively, in a landmark task where prebisected lines are presented to participants. Several factors have been shown to influence pseudoneglect, that is, to vary the magnitude of the left side bias. We performed 2 landmark experiments: 1 online (n = 801) and a 2nd in the laboratory (n = 20). Our results demonstrate that pseudoneglect is strongly modulated by the sequence of trials in a landmark task...
September 4, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28870253/early-presence-of-anti-angiogenesis-related-adverse-events-as-a-potential-biomarker-of-antitumor-efficacy-in-metastatic-gastric-cancer-patients-treated-with-apatinib-a-cohort-study
#11
Xinyang Liu, Shukui Qin, Zhichao Wang, Jianming Xu, Jianping Xiong, Yuxian Bai, Zhehai Wang, Yan Yang, Guoping Sun, Liwei Wang, Leizhen Zheng, Nong Xu, Ying Cheng, Weijian Guo, Hao Yu, Tianshu Liu, Pagona Lagiou, Jin Li
BACKGROUND: Reliable biomarkers of apatinib response in gastric cancer (GC) are lacking. We investigated the association between early presence of common adverse events (AEs) and clinical outcomes in metastatic GC patients. PATIENTS AND METHODS: We conducted a retrospective cohort study using data on 269 apatinib-treated GC patients in two clinical trials. AEs were assessed at baseline until 28 days after the last dose of apatinib. Clinical outcomes were compared between patients with and without hypertension (HTN), proteinuria, or hand and foot syndrome (HFS) in the first 4 weeks...
September 5, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28861849/internal-carotid-artery-occlusion-pathophysiology-diagnosis-and-management
#12
REVIEW
Konark Malhotra, Nitin Goyal, Georgios Tsivgoulis
PURPOSE OF REVIEW: Acute internal carotid artery occlusion (ICAO) is associated with large infarcts and poor clinical outcomes and contributes to morbidity and mortality worldwide. In this review, we discuss various etiologies and pathophysiology of clinical presentations of ICAO, different radiographic patterns, and management of patients with ICAO. RECENT FINDINGS: Recanalization rates remain suboptimal with systemic thrombolysis amongst patients with acute ICAO...
August 31, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28858898/the-accuracy-of-a-handheld-ultrasound-device-for-neuraxial-depth-and-landmark-assessment-a-prospective-cohort-trial
#13
Katherine M Seligman, Carolyn F Weiniger, Brendan Carvalho
This study investigated the accuracy of a wireless handheld ultrasound with pattern recognition software that recognizes lumbar spine bony landmarks and measures depth to epidural space (Accuro, Rivanna Medical, Charlottesville, VA) (AU). AU measurements to epidural space were compared to Tuohy needle depth to epidural space (depth to loss of resistance at epidural placement). Data from 47 women requesting labor epidural analgesia were analyzed. The mean difference between depth to epidural space measured by AU versus needle depth was -0...
August 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28845557/treatment-of-idiopathic-pulmonary-fibrosis-in-australia-and-new-zealand-a-position-statement-from-the-thoracic-society-of-australia-and-new-zealand-and-the-lung-foundation-australia
#14
Helen E Jo, Lauren K Troy, Gregory Keir, Daniel C Chambers, Anne Holland, Nicole Goh, Margaret Wilsher, Sally de Boer, Yuben Moodley, Christopher Grainge, Helen Whitford, Sally Chapman, Paul N Reynolds, Ian Glaspole, David Beatson, Leonie Jones, Peter Hopkins, Tamera J Corte
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease (ILD) of unknown aetiology with a median survival of only 2-5 years. It is characterized by progressive dyspnoea and worsening lung function, ultimately resulting in death. Until recently, there were no effective therapies for IPF; however, with the publication of two landmark clinical trials in 2014, the anti-fibrotic therapies, nintedanib and pirfenidone, have gained widespread approval. This position paper aims to highlight the current evidence for the treatment of IPF, with particular application to the Australian and New Zealand population...
August 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28839486/facial-soft-tissue-thickness-of-midline-in-an-iranian-sample-mri-study
#15
Masume Johari, Farzad Esmaeili, Hadi Hamidi
BACKGROUND AND AIM: To identify human skeletal remains, different methods can be used and using these techniques, important data can be obtained. However, facial reconstruction is the last method to indentify unknown human faces which requires knowledge about facial soft tissue thickness in the different positions of the face. The present study determined the facial soft tissue thickness in the different landmark points on the MRI images of patients referred to Radiology Department of Shahid Madani Hospital...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28837718/adjuvant-chemotherapy-vs-observation-for-patients-with-adverse-pathologic-features-at-radical-cystectomy-previously-treated-with-neoadjuvant-chemotherapy
#16
Thomas Seisen, Asha Jamzadeh, Jeffrey J Leow, Morgan Rouprêt, Alexander P Cole, Stuart R Lipsitz, Adam S Kibel, Paul L Nguyen, Maxine Sun, Mani Menon, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Importance: Despite existing evidence of a benefit associated with cisplatin-based adjuvant chemotherapy (AC) after radical cystectomy (RC) for chemotherapy-naive patients with pT3/T4 and/or pN+ urothelial carcinoma of the bladder (UCB), to our knowledge, no studies have addressed the effectiveness of AC in those who received neoadjuvant chemotherapy (NAC) before surgery. Objective: To assess the comparative effectiveness of AC vs observation for patients with pT3/T4 and/or pN+ UCB previously treated with NAC and RC...
August 24, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28828881/correlates-and-prognostic-impact-of-new-onset-heart-failure-after-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-insights-from-the-infuse-ami-trial
#17
Gennaro Giustino, Björn Redfors, Sorin J Brener, Ajay J Kirtane, Philippe Généreux, Akiko Maehara, Dariusz Dudek, Thomas Neunteufl, D Christopher Metzger, Aaron Crowley, Roxana Mehran, C Michael Gibson, Gregg W Stone
BACKGROUND: The determinants and significance of early (30-day) heart failure symptoms after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) remain unclear. We investigated the clinical and imaging correlates of early post-discharge heart failure in patients with STEMI, and evaluated its impact on clinical outcomes. METHODS: Patients from the INFUSE-AMI trial were categorized according to New York Heart Association (NYHA) functional classification at their 30-day visit (NYHA class ≥2 versus 1)...
August 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28823143/stent-thrombosis-and-optimal-duration-of-dual-antiplatelet-therapy-after-coronary-stenting-in-contemporary-practice
#18
REVIEW
Min Soo Cho, Duk-Woo Park
The introduction of drug-eluting stents (DES) in the practice of percutaneous coronary intervention (PCI) has substantially reduced angiographic and clinical restenosis but is associated with an increasing propensity for very late stent thrombosis (ST). Among several clinical, lesion, or procedure-related predictors of ST, early discontinuation of dual antiplatelet therapy (DAPT) is the most important factor for DES-associated late thrombosis; therefore, the optimal duration of DAPT is a major issue to be critically considered in the current DES era...
September 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28806982/software-guided-versus-nurse-directed-blood-glucose-control-in-critically-ill-patients-the-logic-2-multicenter-randomized-controlled-clinical-trial
#19
Dieter Mesotten, Jasperina Dubois, Tom Van Herpe, Roosmarijn T van Hooijdonk, Ruben Wouters, Domien Coart, Pieter Wouters, Aimé Van Assche, Guy Veraghtert, Bart De Moor, Joost Wauters, Alexander Wilmer, Marcus J Schultz, Greet Van den Berghe
BACKGROUND: Blood glucose control in the intensive care unit (ICU) has the potential to save lives. However, maintaining blood glucose concentrations within a chosen target range is difficult in clinical practice and holds risk of potentially harmful hypoglycemia. Clinically validated computer algorithms to guide insulin dosing by nurses have been advocated for better and safer blood glucose control. METHODS: We conducted an international, multicenter, randomized controlled trial involving 1550 adult, medical and surgical critically ill patients, requiring blood glucose control...
August 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28806011/a-primer-on-bleeding-risk-and-management-strategies-of-newer-oral-anti-platelet-agents-in-cardiovascular-disease
#20
Jimmy Yee, Vishesh Kumar, Amornpol Anuwatworn, Marian Petrasko, Adam Stys
Aspirin, the first antiplatelet agent, has been around since the 19th century, and is one of the most established drugs in history. With the improvement of coronary interventions in the past few decades, there has been more reliance on oral antiplatelet agents to reduce complications of in-stent restenosis/thrombosis. Clopidogrel was initially introduced in 1997, and within the past seven years, two additional oral antiplatelet agents have been approved by the U.S. Food and Drug Administration. With more potent antiplatelet agents comes increased risks of adverse effects...
October 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
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