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https://www.readbyqxmd.com/read/29882445/the-relationship-between-health-related-quality-of-life-and-anabolic-hormone-levels-in-middle-aged-and-elderly-men-with-prediabetes-a-cross-sectional-study
#1
Michał Rabijewski, Lucyna Papierska, Radosław Maksym, Ryszard Tomasiuk, Anna Kajdy, Bogusław Paweł Siekierski
The aim of this study was to compare health-related quality of life (HRQoL) between men with prediabetes (PD) and a control group as well as to investigate the relationship between HRQoL and anabolic hormones. The analysis was carried out in 176 middle-aged (40-59 years) and elderly (60 80 years) men with PD, and 184 control peers. PD was defined according the American Diabetes Association and HRQoL was assessed by the SF-36 questionnaire. Total testosterone (TT), calculated free testosterone, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) were measured...
June 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29846604/long-term-testosterone-supplementation-in-older-men-attenuates-age-related-decline-in-aerobic-capacity
#2
Tinna Traustadóttir, S Mitchell Harman, Panayiotis Tsitouras, Karol M Pencina, Zhuoying Li, Thomas G Travison, Richard Eder, Renee Miciek, Jennifer McKinnon, Erin Woodbury, Shehzad Basaria, Shalender Bhasin, Thomas W Storer
Context: Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity (V˙O2peak) in healthy older men with low testosterone have not been evaluated. Objective: To determine the effects of testosterone supplementation on V˙O2peak during incremental cycle ergometry. Design: Testosterone's Effects on Atherosclerosis Progression in Aging Men trial: double-blind, randomized, placebo-controlled, parallel-group trial...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29745981/evaluation-of-biochemical-endocrine-and-metabolic-biomarkers-for-the-early-diagnosis-of-polycystic-ovary-syndrome-among-non-obese-saudi-women
#3
Maha H Daghestani
OBJECTIVE: To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome (PCOS) among non-obese women. METHODS: A prospective observational cross-sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non-obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non-obese normo-ovulatory women without signs of PCOS (control group; n=44)...
May 10, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29744905/insulin-resistance-and-sex-hormone-binding-globulin-are-independently-correlated-with-low-free-testosterone-levels-in-obese-males
#4
P Souteiro, S Belo, S C Oliveira, J S Neves, D Magalhães, J Pedro, R Bettencourt-Silva, M M Costa, A Varela, J Queirós, P Freitas, D Carvalho
Male obesity is associated with decreased testosterone levels but the pathophysiological mechanisms behind this association are not completely understood. This study aimed to investigate the impact of hyperglycaemia/insulin resistance and sex hormone-binding globulin (SHBG) levels on testosterone levels in a population of obese men. We investigated the impact of several clinical, anthropometric and analytic measures on testosterone levels in 150 obese males. Testosterone deficiency was present in 52.0% of the enrolled patients...
May 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29726665/-protective-effect-of-qilin-pills-on-the-reproductive-function-of-oligoasthenospermia-rats
#5
Kai-Shu Zhang, Fang Zhou, Qi An, Yan-Fei Jia, Long-Long Fu, Wen-Hong Lu, Xiao-Wei Liang, Xue-Jun Shang, Yi-Qun Gu
Objective: To study the protective effect of Qilin Pills (QLP) on the reproductive function of rats with oligoasthenospermia (OAS) induced by tripterygium glycosides. METHODS: Twenty-eight male SD rats were randomly divided into a normal control, an OAS model control, a low-dose QLP, and a high-dose QLP group of equal number. OAS models were made in the latter three groups by intragastrical administration of tripterygium glycosides at 40 mg per kg of the body weight per day, and meanwhile the animals in the low- and high-dose QLP groups were treated with QLP at 1...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29725371/analyses-of-risk-factors-for-polycystic-ovary-syndrome-complicated-with-non-alcoholic-fatty-liver-disease
#6
Jianhai Zhang, Jian Hu, Chunxia Zhang, Yanni Jiao, Xiang Kong, Wei Wang
The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29709501/spurious-testosterone-laboratory-results-in-a-patient-taking-synthetic-alkaline-phosphatase-asfotase-alfa
#7
Alina G Sofronescu, Meredith Ross, Eric Rush, Whitney Goldner
OBJECTIVES: We report a case of discordant total and free testosterone values in a patient with hypogonadism and juvenile hypophosphatasia after he initiated treatment with asfotase alfa, recombinant tissue non-specific alkaline phosphatase. METHODS: Total testosterone was evaluated using immunoassay pre and post initiation of therapy with asfotase alfa, and free testosterone was evaluated using radioimmunoassay and LC-MS/MS while on asfotase alfa therapy. RESULTS: Total testosterone measured by immunoassay was normal prior to therapy with asfotase alfa, and was low post initiation of therapy...
April 27, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29701444/hiit-produces-increases-in-muscle-power-and-free-testosterone-in-male-masters-athletes
#8
P Herbert, L D Hayes, N F Sculthorpe, F M Grace
High-intensity interval training (HIIT) improves peak power output (PPO) in sedentary aging men but has not been examined in masters endurance athletes. Therefore, we investigated whether a six-week program of low-volume HIIT would (i) improve PPO in masters athletes and (ii) whether any change in PPO would be associated with steroid hormone perturbations. Seventeen male masters athletes (60 ± 5 years) completed the intervention, which comprised nine HIIT sessions over six weeks. HIIT sessions involved six 30-s sprints at 40% PPO, interspersed with 3 min active recovery...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29694329/correlation-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-with-hormonal-and-metabolic-parameters-in-women-with-pcos
#9
Vasilios Pergialiotis, Eftihios Trakakis, Christos Parthenis, Erifili Hatziagelaki, Charalampos Chrelias, Nikolaos Thomakos, Nikolaos Papantoniou
Background The purpose of our study is to evaluate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with hormonal and metabolic parameters in patients with polycystic ovarian syndrome (PCOS) in order to assess whether these ratios may become useful tools during the evaluation of the severity of low grade inflammation. Methods The present study is based in secondary outcomes from a prospectively collected patient database. A total of 266 women with PCOS participated in this study and blood a complete blood count examination (CBC) that was used for the calculation of PLR and NLR was available in 182 patients...
April 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29688866/does-the-use-of-hernia-mesh-in-surgical-inguinal-hernia-repairs-cause-male-infertility-a-systematic-review-and-descriptive-analysis
#10
REVIEW
Zhiyong Dong, Stacy Ann Kujawa, Cunchuan Wang, Hong Zhao
OBJECTIVE: The aim of this study was to systematically review the available clinical trials examining male infertility after inguinal hernias were repaired using mesh procedures. METHODS: The Cochrane Library, PubMed, Embase, Web of Science, and Chinese Biomedical Medicine Database were investigated. The Jada score was used to evaluate the quality of the studies, "Oxford Centre for Evidence-based Medicine-Levels of Evidence" was used to assess the level of the trials, and descriptive analysis was used to evaluate the studies...
April 23, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29678493/analysis-and-validation-of-a-new-extended-method-for-estimating-plasma-free-cortisol-including-neutrophil-elastase-and-competition-from-other-steroids
#11
Johanne Gudmand-Hoeyer, Johnny T Ottesen
A non-linear mechanistic model for the distribution of cortisol in plasma on free and bound forms is proposed. The influence of progesterone, testosterone and neutrophil elastase on the cortisol distribution in the blood is investigated. The activity of neutrophil elastase is directly included in the model with the concentration of elastase and the kinetic constants describing the activity of elastase collected in one single input variable. The model is very sensitive towards this input variable and fits data excellently, when it is allowed to be subject specific...
July 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29671886/serum-androgens-and-risk-of-atrial-fibrillation-in-older-men-the-cardiovascular-health-study
#12
Michael A Rosenberg, Molly M Shores, Alvin M Matsumoto, Petra Bůžková, Leslie A Lange, Richard A Kronmal, Susan R Heckbert, Kenneth J Mukamal
BACKGROUND: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined. HYPOTHESIS: Low serum androgens are associated with an increased risk of AF. METHODS: We examined the prospective associations between testosterone, its more active metabolite dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) with risk of AF among 1019 otherwise healthy men with average age 76...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#13
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29590007/prospective-international-randomized-phase-ii-study-of-low-dose-abiraterone-with-food-versus-standard-dose-abiraterone-in-castration-resistant-prostate-cancer
#14
Russell Z Szmulewitz, Cody J Peer, Abiola Ibraheem, Elia Martinez, Mark F Kozloff, Bradley Carthon, R Donald Harvey, Paul Fishkin, Wei Peng Yong, Edmund Chiong, Chadi Nabhan, Theodore Karrison, William D Figg, Walter M Stadler, Mark J Ratain
Purpose Abiraterone acetate (AA) is a standard of care for metastatic castration-resistant prostate cancer (CRPC). Despite a large food effect, AA was administered under fasting conditions in its pivotal trials. We sought to test the hypothesis that low-dose AA (LOW; 250 mg with a low-fat meal) would have comparable activity to standard AA (STD; 1,000 mg fasting) in patients with CRPC. Patients and Methods Patients (n = 72) with progressive CRPC from seven institutions in the United States and Singapore were randomly assigned to STD or LOW...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29564258/the-evaluation-of-the-relationship-between-some-related-hormone-levels-and-diet-in-obese-or-overweight-patients-with-hirsutism-a-randomized-clinical-trial
#15
Atefeh Krouni, Sedighe Forouhari, Bahia Namavarjahromi, Mohammad Hossein Dabbaghmanesh, Arezoo Shayan, Sara Sepasi, Atefeh Zare
Introduction: Hirsutism is a common disorder that has remarkable physical and mental effects on individuals. No appropriate diet has yet specified for individuals with hirsutism. The present study was carried out to examine the effect of high-fibre, low-caloric balanced diet on some related hormone levels in obese or overweight women with hirsutism who had referred to clinics affiliated with Shiraz University of Medical Sciences. Materials and Methods: The present study was a clinical trial that was carried out on 47 obese or overweight women with hirsutism in 2014...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#16
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
May 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29560631/-electroacupuncture-intervention-improves-physical-power-of-aged-rats-with-low-testosterone-by-reducing-chronic-inflammatory-response-of-leydig-cells
#17
Tai-Wan Yao, Jia Liu, Xue-Zhi Li, Lin Ma, Jia-Peng Wu, Xiao-Fang Xi, Yan Fu
OBJECTIVE: To assess the effect of electroacupuncture (EA) on chronic inflammatory response of Leydig cells in aged rats with low testosterone, so as to investigate its underlying mechanism of anti-male reproductive aging. METHODS: Twenty-four 20 months old SD rats were randomly divided into EA, medication and aged control groups ( n = 8 in each), and other 8 young SD rats (2 months of age) were used as the youth control group. EA (2 Hz/100 Hz, 1 mA) was applied to "Guanyuan"(CV 4) and bilate-ral "Shenshu"(BL 23) for 15 min, once daily for 8 weeks except the weekends...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29559206/retrospective-study-of-the-prevalence-and-risk-factors-of-clitoral-adhesions-women-s-health-providers-should-routinely-examine-the-glans-clitoris
#18
Leen Aerts, Rachel S Rubin, Michael Randazzo, Sue W Goldstein, Irwin Goldstein
INTRODUCTION: The glans clitoris is covered by a prepuce that normally moves over the glans surface and can be retracted beyond the corona. Clitoral adhesions, ranging from mild to severe, occur when preputial skin adheres to the glans. Physical examination consistent with clitoral adhesions is based on the inability to visualize the entire glans corona. In this closed compartment, the space underneath the adherent prepuce and clitoris can become irritated, erythematous, or infected and can result in sexual dysfunction...
June 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29546692/vitamin-d-supplementation-does-not-prevent-the-testosterone-decline-in-males-with-advanced-heart-failure-the-evita-trial
#19
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan Pilz
PURPOSE: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. METHODS: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs...
March 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29530796/testosterone-replacement-therapy-for-whom-when-and-how
#20
REVIEW
Christos P Tsametis, Andrea M Isidori
The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in older men is highly debated. The aim of this narrative review is to summarize the steps necessary to formulate a proper diagnosis and to guide toward an individualized treatment. While universally recognized the need to treat the young adults with known causes of pituitary or testicular failure, there are controversies on the cost-benefit of treating testosterone deficiency in older men...
March 9, 2018: Metabolism: Clinical and Experimental
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