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Low free testosterone

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https://www.readbyqxmd.com/read/29209688/correlation-between-benzene-and-testosterone-in-workers-exposed-to-urban-pollution
#1
M V Rosati, A Sancini, F Tomei, C Sacco, V Traversini, A De Vita, D P De Cesare, G Giammichele, F De Marco, F Pagliara, F Massoni, L Ricci, G Tomei, S Ricci
AIM: Many studies have examined the effects of benzene on testosterone. The purpose of this study was to evaluate the possible correlation between the blood levels of benzene and the levels of testosterone. MATERIALS AND METHODS: The study involved a group of 148 subjects. For every worker have been made out a blood sample for the evaluation of benzene and testosterone levels and an urine analysis for the evaluation of the levels of trans, trans-muconic acid and S-phenylmercapturic acid...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29204279/sellar-plasmacytoma-presenting-with-symptoms-of-anterior-pituitary-dysfunction
#2
Ana G Ferreira, Tiago N Silva, Henrique V Luiz, Filipa D Campos, Maria C Cordeiro, Jorge R Portugal
Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. We describe a case associated with extensive anterior pituitary involvement, which is a rare form of presentation. A 68-year-old man was referred to our Endocrinology outpatient clinic due to gynecomastia, reduced libido and sexual impotence...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29198510/does-calculated-free-testosterone-overcome-total-testosterone-in-protecting-from-sexual-symptom-impairment-findings-of-a-cross-sectional-study
#3
Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Donatella Moretti, Federico Dehò, Emanuele Montanari, Francesco Montorsi, Andrea Salonia
BACKGROUND: Although erectile dysfunction (ED) has been associated with low circulating total testosterone (TT) levels, the utility of free testosterone (FT) over TT is debatable. AIM: To assess the relative impact of low TT and low calculated FT (cFT) on androgen-related sexual symptoms in men with ED. METHODS: Data from 485 men were analyzed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the International Index of Erectile Function (IIEF) and the Beck Inventory for Depression (BDI)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29188324/total-vaginectomy-and-urethral-lengthening-at-time-of-neourethral-prelamination-in-transgender-men
#4
Carlos A Medina, Lydia A Fein, Christopher J Salgado
INTRODUCTION AND HYPOTHESIS: For transgender men (TGM), gender-affirmation surgery (GAS) is often the final stage of their gender transition. GAS involves creating a neophallus, typically using tissue remote from the genital region, such as radial forearm free-flap phalloplasty. Essential to this process is vaginectomy. Complexity of vaginal fascial attachments, atrophy due to testosterone use, and need to preserve integrity of the vaginal epithelium for tissue rearrangement add to the intricacy of the procedure during GAS...
November 29, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29186759/effect-of-two-different-doses-of-vitamin-d-supplementation-on-metabolic-profiles-of-insulin-resistant-patients-with-polycystic-ovary-syndrome
#5
Mehri Jamilian, Fatemeh Foroozanfard, Elham Rahmani, Maesoomeh Talebi, Fereshteh Bahmani, Zatollah Asemi
This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (n = 30 each group) daily for 12 weeks. Vitamin D supplementation (4000 IU), compared with vitamin D (1000 IU) and placebo, led to significant reductions in total testosterone (-0...
November 24, 2017: Nutrients
https://www.readbyqxmd.com/read/29183872/endotoxin-initiated-inflammation-reduces-testosterone-production-in-men-of-reproductive-age
#6
Kelton Tremellen, Natalie McPhee, Karma Pearce, Sven Bedson, Manfred Schedlowski, Harald Engler
Inflammation, both acute and chronic is associated with testosterone deficiency, raising the possibility of a direct causal link. One potential trigger for inflammation in obese men is the passage of intestinal bacteria into the circulation due to a breakdown in mucosal barrier integrity. Recently we hypothesized that this endotoxin exposure may cause androgen deficiency in obese men. To test this hypothesis, we analysed the relationship between serum levels of lipopolysaccharide binding protein (LBP), an indirect measure of endotoxin exposure, against male reproductive hormones, inflammatory markers (CRP, IL-1β, IL-6, TNF-α) and adiposity in 75 men...
November 28, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29133315/testosterone-in-advance-age-a-new-zealand-longitudinal-cohort-study-life-and-living-in-advanced-age-te-pu%C3%A4-waitanga-o-ng%C3%A4-tapuwae-kia-ora-tonu
#7
Martin J Connolly, Ngaire Kerse, Tim Wilkinson, Oliver Menzies, Anna Rolleston, Yih Harng Chong, Joanna B Broad, Simon A Moyes, Santosh Jatrana, Ruth Teh
OBJECTIVES: Serum testosterone (T) levels in men decline with age. Low T levels are associated with sarcopenia and frailty in men aged >80 years. T levels have not previously been directly associated with disability in older men. We explored associations between T levels, frailty and disability in a cohort of octogenarian men. SETTING: Data from all men from Life and Living in Advanced Age Cohort Study in New Zealand, a longitudinal cohort study in community-dwelling older adults...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29130715/relationship-of-long-term-macronutrients-intake-on-anabolic-catabolic-hormones-in-female-elite-volleyball-players
#8
Juan Mielgo Ayuso, Michael C Zourdos, Aritz Urdampilleta, Julio Calleja González, Jesús Seco, Alfredo Córdova
INTRODUCTION: Specific macronutrient distribution and training can alter acute and chronic hormone behavior and, subsequently, sport performance. OBJECTIVE: The main aim was to examine relationships between dietary intake and anabolic/catabolic hormone response in elite female volleyball players during a 29-week season. METHODS: Twenty-two elite female volleyballers (26.4 ± 5.6 years; 178 ± 9 cm; 67.1 ± 7.5 kg) had dietary intake (seven-day dietary recall and food frequency questionnaire), blood concentration of anabolic/catabolic hormones concentration, physical performance, and body composition assessed at four time points: a) T1: baseline/pre-testing; b) T2: eleven weeks after T1; c) T3: ten weeks after T2; and d) T4: eight weeks after T3...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29110281/the-effect-of-vitamin-d-supplementation-in-combination-with-low-calorie-diet-on-anthropometric-indices-and-androgen-hormones-in-women-with-polycystic-ovary-syndrome-a-double-blind-randomized-placebo-controlled-trial
#9
S Jafari-Sfidvajani, R Ahangari, M Hozoori, H Mozaffari-Khosravi, H Fallahzadeh, A Nadjarzadeh
PURPOSE: Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women. METHODS: In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo...
November 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29108365/a-3-year-observation-of-testosterone-deficiency-in-chinese-patients-with-chronic-heart-failure
#10
Ying Han, Weiju Sun, Guizhi Sun, Xiaolu Hou, Zhaowei Gong, Jing Xu, Xiuping Bai, Lu Fu
Testosterone deficiency is present in a certain proportion men with chronic heart failure (CHF). Low testosterone levels in American and European patients with CHF lead to the high mortality and readmission rates. Interestingly, this relationship has not been studied in Chinese patients. To this end, 167 Chinese men with CHF underwent clinical and laboratory evaluations associated with determinations of testosterone levels. Total testosterone (TT) levels and sex hormone-binding globulin were measured by chemiluminescence or immunoassays assays and free testosterone (FT) levels were calculated, Based upon results from these assays, patients were divided into either a low testosterone (LT; n = 93) or normal testosterone (NT; n = 74) group...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29090684/neuroactive-steroids-and-affective-symptoms-in-women-across-the-weight-spectrum
#11
Laura E Dichtel, Elizabeth A Lawson, Melanie Schorr, Erinne Meenaghan, Margaret Lederfine Paskal, Kamryn T Eddy, Graziano Pinna, Marianela Nelson, Ann M Rasmusson, Anne Klibanski, Karen K Miller
3α-5α-Tetrahydroprogesterone, a progesterone metabolite also known as allopregnanolone, and 5α-androstane-3α,17β-diol, a testosterone metabolite also known as 3α-androstanediol, are neuroactive steroids and positive GABAA receptor allosteric modulators. Both anorexia nervosa (AN) and obesity are complicated by affective co-morbidities and hypothalamic-pituitary-gonadal dysregulation. However, it is not known whether neuroactive steroid levels are abnormal at the extremes of the weight spectrum. We hypothesized that serum allopregnanolone and 3α-androstanediol levels would be decreased in AN compared to healthy controls (HC) and negatively associated with affective symptoms throughout the weight spectrum, independent of body mass index (BMI)...
November 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29084161/molecular-analysis-of-the-srd5a1-and-srd5a2-genes-in-patients-with-benign-prostatic-hyperplasia-with-regard-to-metabolic-parameters-and-selected-hormone-levels
#12
Aleksandra Rył, Iwona Rotter, Anna Grzywacz, Iwona Małecka, Karolina Skonieczna-Żydecka, Katarzyna Grzesiak, Marcin Słojewski, Aleksandra Szylińska, Olimpia Sipak-Szmigiel, Małgorzata Piasecka, Kinga Walczakiewicz, Maria Laszczyńska
Introduction: The etiology of benign prostatic hyperplasia (BPH) has not so far been fully explicated. However, it is assumed that changes in the levels of hormones associated with aging can contribute to the development of prostatic hyperplasia. Dihydrotestosterone combines with the androgen receptor (AR) proteins of the prostate gland. Enzyme activity is based on two isoenzymes: type 1 and type 2. 5α-reductase type 1 is encoded by the SRD5A1 gene, and type 2 is encoded by the SRD5A2 gene. The aim of our study was to determine the frequency of the SRD5A1 (rs6884552, rs3797177) and SRD5A2 (rs523349, rs12470143) genes' polymorphisms, and to assess the relationships between the genotypes of the tested mutations, and the levels of biochemical and hormonal parameters in patients with BPH...
October 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29068242/heterogenous-origins-of-hyperandrogenism-in-the-polycystic-ovary-syndrome-in-relation-to-body-mass-index-and-insulin-resistance
#13
Shalini Patlolla, Suresh Vaikkakara, Alok Sachan, Ashok Venkatanarasu, Bharath Bachimanchi, Aparna Bitla, Sarala Settipalli, Sumathi Pathiputturu, Roopa Naik Sugali, Sravani Chiri
BACKGROUND: Insulin resistance and obesity are not universal features of polycystic ovary syndrome (PCOS). We planned to assess the differences between patients with nonobese /insulin-sensitive phenotype vs. obese/ insulin-resistant phenotype in terms of the potential mechanisms underlying their hyperandrogenism. MATERIALS AND METHODS: A total of 52 women satisfying Androgen Excess Society (AES) criteria were included. Hormonal and metabolic profile including prolactin, dehydroepiandrosterone sulfate (DHEAS), free testosterone, sex hormone binding globulin (SHBG), fasting plasma glucose and insulin were measured in follicular phase...
October 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29045588/the-mycotoxin-metabolite-deepoxy-deoxynivalenol-increases-apoptosis-and-decreases-steroidogenesis-in-bovine-ovarian-theca-cells
#14
Hilda M Guerrero-Netro, Anthony Estienne, Younès Chorfi, Christopher A Price
The mycotoxin deoxynivalenol (DON) has been shown to inhibit ovarian granulosa cell function in cattle in vitro, but it is not known whether DON or its metabolite deepoxy-DON (DOM-1) affect theca cell function. The objectives of the present study were to determine the effects of DON and of DOM-1 on theca cell steroidogenesis and apoptosis, and to determine the main pathways through which they act. Bovine theca cells were cultured in a non-luteinizing serum-free culture system, and challenged with DON or DOM-1 for 4 d to measure steroidogenesis and apoptosis, for 1-8 h to measure immediate-early genes, and for 5-60 min to measure phosphorylation of intracellular signaling proteins...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28974703/sex-steroid-production-associated-with-puberty-is-absent-in-germ-cell-free-salmon
#15
Lene Kleppe, Eva Andersson, Kai Ove Skaftnesmo, Rolf B Edvardsen, Per Gunnar Fjelldal, Birgitta Norberg, Jan Bogerd, Rüdiger W Schulz, Anna Wargelius
In all vertebrates studied so far, germ cells are not required for pubertal maturation of the gonadal steroidogenic system, subsequent development of secondary sex characteristics and reproductive behavior. To explore if the absence of germ cells affects puberty or growth in Atlantic salmon, germ cell-free (GCF), dnd knockout and wild type (WT) postsmolts were stimulated to enter puberty. No GCF fish entered puberty, whereas 66.7% (males) and 30% (females) WT fish completed or entered puberty, respectively...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28958048/evaluating-calculated-free-testosterone-as-a-predictor-of-morbidity-and-mortality-independent-of-testosterone-for-cross-sectional-and-5-year-longitudinal-health-outcomes-in-older-men-the-concord-health-and-ageing-in-men-project
#16
Benjumin Hsu, Robert G Cumming, Fiona M Blyth, Vasi Naganathan, Louise M Waite, David G Le Couteur, Markus J Seibel, David J Handelsman
To determine whether calculated free testosterone (cFT) provides prognostic information independent of serum T for predicting morbidity and mortality in older men in cross-sectional and 5-year longitudinal analyses. We studied men aged ≥70 years at baseline (n=1705), 2-year and 5-year measuring serum T (liquid chromatography-mass spectrometry), SHBG (immunoassay), cFT (an assumption-free empirical formula) together with 24 morbidity and 4 mortality outcomes. For cross-sectional and longitudinal analyses we employed a joint prediction model using generalized estimating equation models adjusted for age, smoking, comorbidities and BMI with men having both normal T and normal cFT as referent group...
September 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28954982/androgen-replacement-therapy-for-cancer-related-symptoms-in-male-advanced-cancer-patients-study-protocol-for-a-randomised-prospective-trial-artform-study
#17
Kouji Izumi, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Yoshifumi Kadono, Shigeki Nanjo, Tadaaki Yamada, Koushiro Ohtsubo, Seiji Yano, Atsushi Mizokami
Recent studies reveal that hypogonadism with low serum androgen levels is associated with advanced cancer and induction of most cancer-related symptoms. We designed an ARTFORM study to evaluate the efficacy of androgen replacement therapy in male advanced cancer patients. The ARTFORM study is an investigator-initiated, randomised controlled trial comparing intramuscle injection of testosterone enanthate with non-administration in male advanced cancer patients with non-curative locally advanced or metastatic lesions...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28954502/clinical-and-hormonal-features-of-women-with-polycystic-ovary-syndrome-living-in-rural-and-urban-areas
#18
Krzysztof Katulski, Adam Czyzyk, Natalia Podkowa, Agnieszka Podfigurna-Stopa, Natalia Ignaszak, Katarzyna Paczkowska, Sylwia Slawek, Dariusz Szpurek, Blazej Meczekalski
INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women at reproductive age, but its pathology remains unknown. From epidemiological studies it is known that endogenous, mainly genetic and exogenous, environmental factors are of importance. OBJECTIVE: The aim of the study was to compare the phenotype of women diagnosed with PCOS from urban and rural areas of Poland. According to the knowledge of the authors, this is first such study...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28950424/testosterone-does-not-affect-agrin-cleavage-in-mobility-limited-older-men-despite-improvement-in-physical-function
#19
T Gagliano-Jucá, T W Storer, K M Pencina, T G Travison, Z Li, G Huang, S Hettwer, P Dahinden, S Bhasin, S Basaria
In a subset of men, sarcopenia and physical dysfunction occur due to destabilization of the neuromuscular junction (NMJ), which is manifested by elevated serum concentrations of C-terminal agrin fragment (CAF). Testosterone administration improves physical function in some studies; however, its effects on serum circulating CAF concentrations remain unknown. Here we evaluate the effects of testosterone administration on circulating CAF levels in mobility-limited men with low testosterone aged 65 or older participating in the Testosterone in Older Men with Mobility Limitations (TOM) Trial...
September 26, 2017: Andrology
https://www.readbyqxmd.com/read/28950181/cross-sectional-study-of-the-determinants-and-associations-of-sex-hormone-binding-globulin-concentrations-in-first-degree-relatives-fdr-of-patients-with-type-2-diabetes-mellitus
#20
N A Abdella, O A Mojiminiyi
AIMS: This study explores the determinants of sex hormone binding globulin (SHBG) and associations with categories of glucose intolerance and undiagnosed diabetes in first-degree relatives (FDR) of patients with Type 2 Diabetes Mellitus (T2D). METHODS: Anthropometric indices, fasting lipids, glucose, insulin, adiponectin, leptin, SHBG, estradiol (E2), testosterone (TT), androstenedione (AND), dehydroepiandrosterone sulphate (DHEA-S), high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) were measured in 584 FDR...
September 5, 2017: Diabetes Research and Clinical Practice
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