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https://www.readbyqxmd.com/read/29688866/does-the-use-of-hernia-mesh-in-surgical-inguinal-hernia-repairs-cause-male-infertility-a-systematic-review-and-descriptive-analysis
#1
REVIEW
Zhiyong Dong, Stacy Ann Kujawa, Cunchuan Wang, Hong Zhao
OBJECTIVE: The aim of this study was to systematically review the available clinical trials examining male infertility after inguinal hernias were repaired using mesh procedures. METHODS: The Cochrane Library, PubMed, Embase, Web of Science, and Chinese Biomedical Medicine Database were investigated. The Jada score was used to evaluate the quality of the studies, "Oxford Centre for Evidence-based Medicine-Levels of Evidence" was used to assess the level of the trials, and descriptive analysis was used to evaluate the studies...
April 23, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29678493/analysis-and-validation-of-a-new-extended-method-for-estimating-plasma-free-cortisol-including-neutrophil-elastase-and-competition-from-other-steroids
#2
Johanne Gudmand-Hoeyer, Johnny T Ottesen
A non-linear mechanistic model for the distribution of cortisol in plasma on free and bound forms is proposed. The influence of progesterone, testosterone and neutrophil elastase on the cortisol distribution in the blood is investigated. The activity of neutrophil elastase is directly included in the model with the concentration of elastase and the kinetic constants describing the activity of elastase collected in one single input variable. The model is very sensitive towards this input variable and fits data excellently, when it is allowed to be subject specific...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29671886/serum-androgens-and-risk-of-atrial-fibrillation-in-older-men-the-cardiovascular-health-study
#3
Michael A Rosenberg, Molly M Shores, Alvin M Matsumoto, Petra Bůžková, Leslie A Lange, Richard A Kronmal, Susan R Heckbert, Kenneth J Mukamal
BACKGROUND: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined. HYPOTHESIS: Low serum androgens are associated with an increased risk of AF. METHODS: We examined the prospective associations between testosterone, its more active metabolite dihydrotestosterone (DHT), and sex-hormone binding globulin (SHBG) with risk of AF among 1019 otherwise healthy men of average age 76...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29623697/efficacy-and-safety-of-a-mixed-extract-of-trigonella-foenum-graecum-seed-and-lespedeza-cuneata-in-the-treatment-of-testosterone-deficiency-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee, Nam Cheol Park
PURPOSE: The aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS). MATERIALS AND METHODS: Patients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29590007/prospective-international-randomized-phase-ii-study-of-low-dose-abiraterone-with-food-versus-standard-dose-abiraterone-in-castration-resistant-prostate-cancer
#5
Russell Z Szmulewitz, Cody J Peer, Abiola Ibraheem, Elia Martinez, Mark F Kozloff, Bradley Carthon, R Donald Harvey, Paul Fishkin, Wei Peng Yong, Edmund Chiong, Chadi Nabhan, Theodore Karrison, William D Figg, Walter M Stadler, Mark J Ratain
Purpose Abiraterone acetate (AA) is a standard of care for metastatic castration-resistant prostate cancer (CRPC). Despite a large food effect, AA was administered under fasting conditions in its pivotal trials. We sought to test the hypothesis that low-dose AA (LOW; 250 mg with a low-fat meal) would have comparable activity to standard AA (STD; 1,000 mg fasting) in patients with CRPC. Patients and Methods Patients (n = 72) with progressive CRPC from seven institutions in the United States and Singapore were randomly assigned to STD or LOW...
March 28, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29564258/the-evaluation-of-the-relationship-between-some-related-hormone-levels-and-diet-in-obese-or-overweight-patients-with-hirsutism-a-randomized-clinical-trial
#6
Atefeh Krouni, Sedighe Forouhari, Bahia Namavarjahromi, Mohammad Hossein Dabbaghmanesh, Arezoo Shayan, Sara Sepasi, Atefeh Zare
Introduction: Hirsutism is a common disorder that has remarkable physical and mental effects on individuals. No appropriate diet has yet specified for individuals with hirsutism. The present study was carried out to examine the effect of high-fibre, low-caloric balanced diet on some related hormone levels in obese or overweight women with hirsutism who had referred to clinics affiliated with Shiraz University of Medical Sciences. Materials and Methods: The present study was a clinical trial that was carried out on 47 obese or overweight women with hirsutism in 2014...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#7
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29560631/-electroacupuncture-intervention-improves-physical-power-of-aged-rats-with-low-testosterone-by-reducing-chronic-inflammatory-response-of-leydig-cells
#8
Tai-Wan Yao, Jia Liu, Xue-Zhi Li, Lin Ma, Jia-Peng Wu, Xiao-Fang Xi, Yan Fu
OBJECTIVE: To assess the effect of electroacupuncture (EA) on chronic inflammatory response of Leydig cells in aged rats with low testosterone, so as to investigate its underlying mechanism of anti-male reproductive aging. METHODS: Twenty-four 20 months old SD rats were randomly divided into EA, medication and aged control groups ( n = 8 in each), and other 8 young SD rats (2 months of age) were used as the youth control group. EA (2 Hz/100 Hz, 1 mA) was applied to "Guanyuan"(CV 4) and bilate-ral "Shenshu"(BL 23) for 15 min, once daily for 8 weeks except the weekends...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29559206/retrospective-study-of-the-prevalence-and-risk-factors-of-clitoral-adhesions-women-s-health-providers-should-routinely-examine-the-glans-clitoris
#9
Leen Aerts, Rachel S Rubin, Michael Randazzo, Sue W Goldstein, Irwin Goldstein
INTRODUCTION: The glans clitoris is covered by a prepuce that normally moves over the glans surface and can be retracted beyond the corona. Clitoral adhesions, ranging from mild to severe, occur when preputial skin adheres to the glans. Physical examination consistent with clitoral adhesions is based on the inability to visualize the entire glans corona. In this closed compartment, the space underneath the adherent prepuce and clitoris can become irritated, erythematous, or infected and can result in sexual dysfunction...
March 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29546692/vitamin-d-supplementation-does-not-prevent-the-testosterone-decline-in-males-with-advanced-heart-failure-the-evita-trial
#10
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Jens Dreier, Joachim Kuhn, Cornelius Knabbe, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Jochen Börgermann, Stefan Pilz
PURPOSE: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. METHODS: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs...
March 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29530796/testosterone-replacement-therapy-for-whom-when-and-how
#11
REVIEW
Christos P Tsametis, Andrea M Isidori
The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in older men is highly debated. The aim of this narrative review is to summarize the steps necessary to formulate a proper diagnosis and to guide toward an individualized treatment. While universally recognized the need to treat the young adults with known causes of pituitary or testicular failure, there are controversies on the cost-benefit of treating testosterone deficiency in older men...
March 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29511577/the-relationship-between-lipoprotein-associated-phospholipase-a2-with-cardiovascular-risk-factors-in-testosterone-deficiency
#12
Mustafa Keleşoğlu, Fuat Kızılay, Burcu Barutçuoğlu, Güneş Başol, Fulden Saraç, Işıl Mutaf, Bülent Semerci
Objective: Lipoprotein-associated phospholipase A2 (Lp-PLA2) which is believed to play a role in atherosclerotic inflammatory process due to its function in hydrolysis of phospholipids and release of pro-inflammatory products, is considered as a novel biomarker for vascular risk. In this study we aimed to investigate the alterations in Lp-PLA2 and its relationship with other cardiovascular risk factors in patients with testosterone deficiency. Material and methods: Forty hypogonadic male and 30 healthy male aged between 18-50 years were enrolled in this study...
March 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29510819/primary-empty-sella-syndrome-and-the-prevalence-of-hormonal-dysregulation
#13
Matthias K Auer, Mareike R Stieg, Alexander Crispin, Caroline Sievers, Günter K Stalla, Anna Kopczak
BACKGROUND: Empty sella is the neuroradiological or pathological finding of an apparently empty sella turcica containing no pituitary tissue. The prevalence of primary empty sella, i.e., empty sella without any discernible cause, is not precisely known; estimates range from 2% to 20%. Technical advances in neuroradiology have made empty sella an increasingly common incidental finding. It remains unclear whether, and to what extent, asymptomatic adult patients with an incidentally discovered empty sella should undergo diagnostic testing for hormonal disturbances...
February 16, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29507393/plasma-steroids-body-composition-and-fat-distribution-effects-of-age-sex-and-exercise-training
#14
Zihong He, Tuomo Rankinen, Arthur S Leon, James S Skinner, André Tchernof, Claude Bouchard
BACKGROUND/OBJECTIVES: Plasma steroid hormone levels vary between men and women, but their associations with BMI and adiposity are controversial. Furthermore, little is known about the role of exercise programs on the relationship between steroid hormones and adiposity. This report evaluates these relationships for plasma levels of adrenal, gonadal, and conjugated steroids with body composition and fat distribution in sedentary men and women, aged 17-65 years, and their responses to an exercise program...
March 5, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29496979/hormonal-metabolic-and-skeletal-phenotype-of-schaaf-yang-syndrome-a-comparison-to-prader-willi-syndrome
#15
John M McCarthy, Bonnie M McCann-Crosby, Megan E Rech, Jiani Yin, Chun-An Chen, May A Ali, HaiThuy N Nguyen, Jennifer L Miller, Christian P Schaaf
BACKGROUND: Nonsense and frameshift mutations in the maternally imprinted, paternally expressed gene MAGEL2, located in the Prader-Willi critical region 15q11-15q13, have been reported to cause Schaaf-Yang syndrome (SYS), a genetic disorder that manifests as developmental delay/intellectual disability, hypotonia, feeding difficulties and autism spectrum disorder. Prader-Willi syndrome (PWS) is a genetic disorder characterised by severe infantile hypotonia, hypogonadotrophic hypogonadism, early childhood onset obesity/hyperphagia, developmental delay/intellectual disability and short stature...
March 1, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29494664/cardiorespiratory-enzymatic-and-hormonal-responses-during-and-after-walking-while-fasting
#16
José Vilaça-Alves, Fernanda Muller, Claudio Rosa, Rita Payan-Carreira, Rafael Lund, Filipe Matos, Nuno Garrido, Francisco José Saavedra, Victor Machado Reis
The aim of the present study was to observe whether performing a low intensity endurance exercise following an overnight fasted (FAST) or fed (FED) condition promotes different cardiorespiratory, enzymatic and hormonal responses. Nine male physical active subjects, (age 21.89 ± 2.52 years old, height 175.89 ± 5.16 cm, weight 72.10 ± 4.31 kg, estimated body fat 7.25 ± 2.11%), randomly performed two sessions of 45 minutes' low intensity exercise (individual ventilator threshold) interspersed by seven days, differentiated only in whether they were provided with a standardized meal or not...
2018: PloS One
https://www.readbyqxmd.com/read/29471520/effect-of-exposure-to-second-hand-smoke-from-husbands-on-biochemical-hyperandrogenism-metabolic-syndrome-and-conception-rates-in-women-with-polycystic-ovary-syndrome-undergoing-ovulation-induction
#17
Jian Li, Q Wu, Xiao-Ke Wu, Zhong-Ming Zhou, Ping Fu, Xiu-Hua Chen, Ying Yan, Xin Wang, Zheng-Wang Yang, Wei-Li Li, Elisabet Stener-Victorin, Richard S Legro, Ernest Hung-Yu Ng, Heping Zhang, Ben Willem J Mol, Chi Chiu Wang
STUDY QUESTION: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction? SUMMARY ANSWER: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS. WHAT IS KNOWN ALREADY: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#18
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29465156/the-impact-of-serum-adropin-and-ischemia-modified-albumin-levels-based-on-bmi-in-pcos
#19
Zeynep Ozturk Inal, Sami Erdem, Yavuz Gederet, Cevdet Duran, Zehra Kucukaydin, Huseyin Kurku, Derya Kilic Sakarya
INTRODUCTION: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and body mass index (BMI) on serum adropin and ischemia modified albumin (IMA) levels. MATERIALS AND METHODS: This prospective cross-sectional study was performed with a total of 120 women [group1; non-PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30) and group 2; PCOS = 60 (BMI <25 = 30, BMI ≥25 = 30)]. Blood samples were collected between the third and fifth days of the women's menstrual cycles after a night of fasting...
February 21, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29462095/hormonal-metabolic-and-endometrial-safety-of-testosterone-vaginal-cream-versus-estrogens-for-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-a-randomized-placebo-controlled-study
#20
Tatiane Fernandes, Adriana O Pedro, Luiz F Baccaro, Lucia H Costa-Paiva
OBJECTIVE: The aim of the study was to evaluate the laboratory and endometrial safety of topical testosterone versus topical estrogen for the treatment of vaginal atrophy in postmenopausal women. METHODS: This was a randomized, placebo-controlled trial of 60 postmenopausal women aged 40 to 70 years at the Menopause Clinic of CAISM UNICAMP. Women were randomized into three vaginal treatment groups: estrogen, testosterone, or placebo. The treatment was applied 3 times a week for 12 weeks...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
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