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Robert C. Whitaker

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https://www.readbyqxmd.com/read/27614660/feasibility-and-full-course-dosimetry-of-an-intraoperatively-placed-multichannel-brachytherapy-catheter-for-accelerated-partial-breast-irradiation
#1
Bradley J Stish, Deanna H Pafundi, Tina J Hieken, Thomas J Whitaker, Keith M Furutani, James W Jakub, Judy C Boughey, Amy C Degnim, Luke B McLemore, Benjamin Mou, Robert W Mutter, Sean S Park
PURPOSE: Determine feasibility and resultant dosimetry of an intraoperatively placed multichannel intracavitary brachytherapy catheter for accelerated partial breast irradiation (APBI). METHODS: Patients with breast cancer underwent intraoperative brachytherapy catheter placement based on frozen section analysis with immediate postoperative APBI. The planning target volume evaluation (PTVEval) and organs at risk were contoured on daily pretreatment CT scans for each patient, and the original treatment plan was applied to assess full-course dosimetry...
September 7, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27542518/physiological-and-behavioral-adaptations-in-bats-living-at-high-latitudes
#2
Justin G Boyles, Liam P McGuire, Esmarie Boyles, Jesika P Reimer, Christopher A C Brooks, Robert W Rutherford, Teresa A Rutherford, John O Whitaker, Gary F McCracken
Widespread animals at the extremes of the species' distribution experience ecological constraints different than individuals in the core of the distribution. For example, small endotherms at very high latitudes face short summers with cool temperatures and a lack of true darkness. In particular, insectivorous bats at high latitudes may experience constraints because of their unique life history traits, and may have different energy requirements than bats at lower latitudes. To evaluate the extent of these differences, we estimated an energy budget and refueling rates for reproductively active female little brown bats (Myotis lucifugus) roosting in buildings in eastern Alaska (~63°N)...
October 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27439416/erratum-to-a-novel-treatment-schedule-for-rapid-completion-of-surgery-and-radiation-in-early-stage-breast-cancer
#3
Tina J Hieken, Robert W Mutter, James W Jakub, Judy C Boughey, Amy C Degnim, William R Sukov, Stephanie Childs, Kimberly S Corbin, Keith M Furutani, Thomas J Whitaker, Sean S Park
No abstract text is available yet for this article.
July 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27426836/bedtime-in-preschool-aged-children-and-risk-for-adolescent-obesity
#4
Sarah E Anderson, Rebecca Andridge, Robert C Whitaker
OBJECTIVE: To determine whether preschool-aged children with earlier bedtimes have a lower risk for adolescent obesity and whether this risk reduction is modified by maternal sensitivity. STUDY DESIGN: Data from 977 of 1364 participants in the Study of Early Child Care and Youth Development were analyzed. Healthy singleton-births at 10 US sites in 1991 were eligible for enrollment. In 1995-1996, mothers reported their preschool-aged (mean = 4.7 years) child's typical weekday bedtime, and mother-child interaction was observed to assess maternal sensitivity...
September 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27334215/a-novel-treatment-schedule-for-rapid-completion-of-surgery-and-radiation-in-early-stage-breast-cancer
#5
Tina J Hieken, Robert W Mutter, James W Jakub, Judy C Boughey, Amy C Degnim, William R Sukov, Stephanie Childs, Kimberly S Corbin, Keith M Furutani, Thomas J Whitaker, Sean S Park
BACKGROUND: Data support the use of accelerated partial-breast irradiation (APBI) for early-stage breast cancer. We initiated a prospective protocol for intraoperative APBI catheter placement using a multi-lumen strut-based device. We hypothesized that with intraoperative pathology assessment of margins and sentinel nodes, all locoregional treatment (surgery and APBI) could be completed within 10 days with acceptable complication rates and cosmesis. METHODS: Eligible patients included women age 50 years or older with clinical T1 estrogen receptor positive (ER+) sentinel lymph node (SLN)-negative invasive ductal cancer or pure ductal carcinoma in situ...
October 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27216050/biochemical-characterization-of-the-active-anti-hepatitis-c-virus-metabolites-of-2-6-diaminopurine-ribonucleoside-prodrug-compared-to-sofosbuvir-and-bms-986094
#6
Maryam Ehteshami, Sijia Tao, Tugba Ozturk, Longhu Zhou, Jong Hyun Cho, Hongwang Zhang, Sheida Amiralaei, Jadd R Shelton, Xiao Lu, Ahmed Khalil, Robert A Domaoal, Richard A Stanton, Justin E Suesserman, Biing Lin, Sam S Lee, Franck Amblard, Tony Whitaker, Steven J Coats, Raymond F Schinazi
Ribonucleoside analog inhibitors (rNAI) target the hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B) and cause RNA chain termination. Here, we expand our studies on β-d-2'-C-methyl-2,6-diaminopurine-ribonucleotide (DAPN) phosphoramidate prodrug 1 (PD1) as a novel investigational inhibitor of HCV. DAPN-PD1 is metabolized intracellularly into two distinct bioactive nucleoside triphosphate (TP) analogs. The first metabolite, 2'-C-methyl-GTP, is a well-characterized inhibitor of NS5B polymerase, whereas the second metabolite, 2'-C-methyl-DAPN-TP, behaves as an adenosine base analog...
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27087142/dental-histology-of-coelophysis-bauri-and-the-evolution-of-tooth-attachment-tissues-in-early-dinosaurs
#7
Raymond K M Fong, Aaron R H LeBlanc, David S Berman, Robert R Reisz
Studies of dinosaur teeth have focused primarily on external crown morphology and thus, use shed or in situ tooth crowns, and are limited to the enamel and dentine dental tissues. As a result, the full suites of periodontal tissues that attach teeth to the jaws remain poorly documented, particularly in early dinosaurs. These tissues are an integral part of the tooth and thus essential to a more complete understanding of dental anatomy, development, and evolution in dinosaurs. To identify the tooth attachment tissues in early dinosaurs, histological thin sections were prepared from the maxilla and dentary of a partial skull of the early theropod Coelophysis bauri from the Upper Triassic (Rhaetian- 209-201 Ma) Whitaker Quarry, New Mexico, USA...
July 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27070408/multiple-markers-of-cortical-morphology-reveal-evidence-of-supragranular-thinning-in-schizophrenia
#8
K Wagstyl, L Ronan, K J Whitaker, I M Goodyer, N Roberts, T J Crow, P C Fletcher
In vivo structural neuroimaging can reliably identify changes to cortical morphology and its regional variation but cannot yet relate these changes to specific cortical layers. We propose, however, that by synthesizing principles of cortical organization, including relative contributions of different layers to sulcal and gyral thickness, regional patterns of variation in thickness of different layers across the cortical sheet and profiles of layer variation across functional hierarchies, it is possible to develop indirect morphological measures as markers of more specific cytoarchitectural changes...
April 12, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26985037/role-of-ventral-subiculum-in-context-induced-relapse-to-alcohol-seeking-after-punishment-imposed-abstinence
#9
Nathan J Marchant, Erin J Campbell, Leslie R Whitaker, Brandon K Harvey, Konstantin Kaganovsky, Sweta Adhikary, Bruce T Hope, Robert C Heins, Thomas E Prisinzano, Eyal Vardy, Antonello Bonci, Jennifer M Bossert, Yavin Shaham
UNLABELLED: In many human alcoholics, abstinence is self-imposed because of the negative consequences of excessive alcohol use, and relapse is often triggered by exposure to environmental contexts associated with prior alcohol drinking. We recently developed a rat model of this human condition in which we train alcohol-preferring P rats to self-administer alcohol in one context (A), punish the alcohol-reinforced responding in a different context (B), and then test for relapse to alcohol seeking in Contexts A and B without alcohol or shock...
March 16, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26883369/spot-scanned-pancreatic-stereotactic-body-proton-therapy-a-dosimetric-feasibility-and-robustness-study
#10
Terence T Sio, Kenneth W Merrell, Chris J Beltran, Jonathan B Ashman, Kathleen A Hoeft, Robert C Miller, Thomas J Whitaker, Stephanie K Wurgler, Erik J Tryggestad
PURPOSE: We explored the dosimetric potential of spot-scanned stereotactic body proton therapy (SBPT) for pancreatic cancer. METHODS: We compared SBPT to stereotactic body intensity-modulated radiotherapy (SB-IMRT) in 10 patients. We evaluated 3 variables in SBPT planning: (1) 4 and 6 mm spot size; (2) single vs. multi-field optimization (SFO vs. MFO); and (3) optimization target volume (OTV) expansion. Robustness analysis was performed with unidirectional isocenter shifts of ±3 mm in x, y, and z and ±3% stopping power uncertainties...
February 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/26597415/the-rationale-design-and-baseline-characteristics-of-prevent-dm-a-community-based-comparative-effectiveness-trial-of-lifestyle-intervention-and-metformin-among-latinas-with-prediabetes
#11
RANDOMIZED CONTROLLED TRIAL
Alberly Perez, Victor A Alos, Adam Scanlan, Catarina M Maia, Adam Davey, Robert C Whitaker, Gary D Foster, Ronald T Ackermann, Matthew J O'Brien
Promotora Effectiveness Versus Metformin Trial (PREVENT-DM) is a randomized comparative effectiveness trial of a lifestyle intervention based on the Diabetes Prevention Program delivered by community health workers (or promotoras), metformin, and standard care. Eligibility criteria are Hispanic ethnicity, female sex, age ≥ 20 years, fluent Spanish-speaking status, BMI ≥ 23 kg/m(2), and prediabetes. We enrolled 92 participants and randomized them to one of the following three groups: standard care, DPP-based lifestyle intervention, or metformin...
November 2015: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/26580144/relationships-heal
#12
Robert C Whitaker
No abstract text is available yet for this article.
2016: Permanente Journal
https://www.readbyqxmd.com/read/26053661/maternal-hiv-1-envelope-specific-antibody-responses-and-reduced-risk-of-perinatal-transmission
#13
Sallie R Permar, Youyi Fong, Nathan Vandergrift, Genevieve G Fouda, Peter Gilbert, Robert Parks, Frederick H Jaeger, Justin Pollara, Amanda Martelli, Brooke E Liebl, Krissey Lloyd, Nicole L Yates, R Glenn Overman, Xiaoying Shen, Kaylan Whitaker, Haiyan Chen, Jamie Pritchett, Erika Solomon, Emma Friberg, Dawn J Marshall, John F Whitesides, Thaddeus C Gurley, Tarra Von Holle, David R Martinez, Fangping Cai, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Raul Louzao, Samantha Wilkes, Saheli Datta, Marcella Sarzotti-Kelsoe, Hua-Xin Liao, Guido Ferrari, S Munir Alam, David C Montefiori, Thomas N Denny, M Anthony Moody, Georgia D Tomaras, Feng Gao, Barton F Haynes
Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, we aimed to define humoral immune correlates of risk of mother-to-child transmission (MTCT) of HIV-1, including responses associated with protection in the RV144 vaccine trial. Eighty-three untreated, HIV-1-transmitting mothers and 165 propensity score-matched nontransmitting mothers were selected from the Women and Infants Transmission Study (WITS) of US nonbreastfeeding, HIV-1-infected mothers...
July 1, 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26024851/the-comparative-efficacy-of-lifestyle-intervention-and-metformin-by-educational-attainment-in-the-diabetes-prevention-program
#14
RANDOMIZED CONTROLLED TRIAL
Matthew J O'Brien, Robert C Whitaker, Daohai Yu, Ronald T Ackermann
OBJECTIVE: Educational attainment is inversely associated with type 2 diabetes risk, but it is unknown whether education impacts individuals' diabetes prevention efforts. We examined the comparative efficacy of intensive lifestyle intervention and metformin by educational attainment among participants in the Diabetes Prevention Program (DPP), an ongoing U.S. multi-site trial beginning in 1996. METHODS: We studied 2,910 DPP participants randomized to receive lifestyle intervention, metformin, or placebo...
August 2015: Preventive Medicine
https://www.readbyqxmd.com/read/26023095/the-feasibility-acceptability-and-preliminary-effectiveness-of-a-promotora-led-diabetes-prevention-program-pl-dpp-in-latinas-a-pilot-study
#15
Matthew J O'Brien, Alberly Perez, Victor A Alos, Robert C Whitaker, Jody D Ciolino, David C Mohr, Ronald T Ackermann
PURPOSE: The purpose of this pilot study is to test the feasibility, acceptability, and preliminary effectiveness of a Promotora-Led Diabetes Prevention Program (PL-DPP) in Hispanic women (Latinas). METHODS: Twenty Latina adults with prediabetes were enrolled in this single-arm pilot trial of PL-DPP. Participants underwent a year-long lifestyle intervention consisting of 24 sessions divided into 14 weekly core sessions and 10 post-core sessions offered either biweekly or monthly...
August 2015: Diabetes Educator
https://www.readbyqxmd.com/read/26018901/corrigendum-analysis-of-the-genetic-phylogeny-of-multifocal-prostate-cancer-identifies-multiple-independent-clonal-expansions-in-neoplastic-and-morphologically-normal-prostate-tissue
#16
Colin S Cooper, Rosalind Eeles, David C Wedge, Peter Van Loo, Gunes Gundem, Ludmil B Alexandrov, Barbara Kremeyer, Adam Butler, Andrew G Lynch, Niedzica Camacho, Charlie E Massie, Jonathan Kay, Hayley J Luxton, Sandra Edwards, Zsofia Kote-Jarai, Nening Dennis, Sue Merson, Daniel Leongamornlert, Jorge Zamora, Cathy Corbishley, Sarah Thomas, Serena Nik-Zainal, Manasa Ramakrishna, Sarah O'Meara, Lucy Matthews, Jeremy Clark, Rachel Hurst, Richard Mithen, Robert G Bristow, Paul C Boutros, Michael Fraser, Susanna Cooke, Keiran Raine, David Jones, Andrew Menzies, Lucy Stebbings, Jon Hinton, Jon Teague, Stuart McLaren, Laura Mudie, Claire Hardy, Elizabeth Anderson, Olivia Joseph, Victoria Goody, Ben Robinson, Mark Maddison, Stephen Gamble, Christopher Greenman, Dan Berney, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, Christopher Woodhouse, David Nicol, Erik Mayer, Tim Dudderidge, Nimish C Shah, Vincent Gnanapragasam, Thierry Voet, Peter Campbell, Andrew Futreal, Douglas Easton, Anne Y Warren, Christopher S Foster, Michael R Stratton, Hayley C Whitaker, Ultan McDermott, Daniel S Brewer, David E Neal
No abstract text is available yet for this article.
June 2015: Nature Genetics
https://www.readbyqxmd.com/read/25788699/the-evolution-of-compositionally-and-functionally-distinct-actin-filaments
#17
REVIEW
Peter W Gunning, Umesh Ghoshdastider, Shane Whitaker, David Popp, Robert C Robinson
The actin filament is astonishingly well conserved across a diverse set of eukaryotic species. It has essentially remained unchanged in the billion years that separate yeast, Arabidopsis and man. In contrast, bacterial actin-like proteins have diverged to the extreme, and many of them are not readily identified from sequence-based homology searches. Here, we present phylogenetic analyses that point to an evolutionary drive to diversify actin filament composition across kingdoms. Bacteria use a one-filament-one-function system to create distinct filament systems within a single cell...
June 1, 2015: Journal of Cell Science
https://www.readbyqxmd.com/read/25730763/analysis-of-the-genetic-phylogeny-of-multifocal-prostate-cancer-identifies-multiple-independent-clonal-expansions-in-neoplastic-and-morphologically-normal-prostate-tissue
#18
Colin S Cooper, Rosalind Eeles, David C Wedge, Peter Van Loo, Gunes Gundem, Ludmil B Alexandrov, Barbara Kremeyer, Adam Butler, Andrew G Lynch, Niedzica Camacho, Charlie E Massie, Jonathan Kay, Hayley J Luxton, Sandra Edwards, Zsofia Kote-Jarai, Nening Dennis, Sue Merson, Daniel Leongamornlert, Jorge Zamora, Cathy Corbishley, Sarah Thomas, Serena Nik-Zainal, Manasa Ramakrishna, Sarah O'Meara, Lucy Matthews, Jeremy Clark, Rachel Hurst, Richard Mithen, Robert G Bristow, Paul C Boutros, Michael Fraser, Susanna Cooke, Keiran Raine, David Jones, Andrew Menzies, Lucy Stebbings, Jon Hinton, Jon Teague, Stuart McLaren, Laura Mudie, Claire Hardy, Elizabeth Anderson, Olivia Joseph, Victoria Goody, Ben Robinson, Mark Maddison, Stephen Gamble, Christopher Greenman, Dan Berney, Steven Hazell, Naomi Livni, Cyril Fisher, Christopher Ogden, Pardeep Kumar, Alan Thompson, Christopher Woodhouse, David Nicol, Erik Mayer, Tim Dudderidge, Nimish C Shah, Vincent Gnanapragasam, Thierry Voet, Peter Campbell, Andrew Futreal, Douglas Easton, Anne Y Warren, Christopher S Foster, Michael R Stratton, Hayley C Whitaker, Ultan McDermott, Daniel S Brewer, David E Neal
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work in morphologically normal tissue were also at work in cancer. Our observations demonstrate the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis...
April 2015: Nature Genetics
https://www.readbyqxmd.com/read/25693563/integrative-analysis-of-111-reference-human-epigenomes
#19
Anshul Kundaje, Wouter Meuleman, Jason Ernst, Misha Bilenky, Angela Yen, Alireza Heravi-Moussavi, Pouya Kheradpour, Zhizhuo Zhang, Jianrong Wang, Michael J Ziller, Viren Amin, John W Whitaker, Matthew D Schultz, Lucas D Ward, Abhishek Sarkar, Gerald Quon, Richard S Sandstrom, Matthew L Eaton, Yi-Chieh Wu, Andreas R Pfenning, Xinchen Wang, Melina Claussnitzer, Yaping Liu, Cristian Coarfa, R Alan Harris, Noam Shoresh, Charles B Epstein, Elizabeta Gjoneska, Danny Leung, Wei Xie, R David Hawkins, Ryan Lister, Chibo Hong, Philippe Gascard, Andrew J Mungall, Richard Moore, Eric Chuah, Angela Tam, Theresa K Canfield, R Scott Hansen, Rajinder Kaul, Peter J Sabo, Mukul S Bansal, Annaick Carles, Jesse R Dixon, Kai-How Farh, Soheil Feizi, Rosa Karlic, Ah-Ram Kim, Ashwinikumar Kulkarni, Daofeng Li, Rebecca Lowdon, GiNell Elliott, Tim R Mercer, Shane J Neph, Vitor Onuchic, Paz Polak, Nisha Rajagopal, Pradipta Ray, Richard C Sallari, Kyle T Siebenthall, Nicholas A Sinnott-Armstrong, Michael Stevens, Robert E Thurman, Jie Wu, Bo Zhang, Xin Zhou, Arthur E Beaudet, Laurie A Boyer, Philip L De Jager, Peggy J Farnham, Susan J Fisher, David Haussler, Steven J M Jones, Wei Li, Marco A Marra, Michael T McManus, Shamil Sunyaev, James A Thomson, Thea D Tlsty, Li-Huei Tsai, Wei Wang, Robert A Waterland, Michael Q Zhang, Lisa H Chadwick, Bradley E Bernstein, Joseph F Costello, Joseph R Ecker, Martin Hirst, Alexander Meissner, Aleksandar Milosavljevic, Bing Ren, John A Stamatoyannopoulos, Ting Wang, Manolis Kellis
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression...
February 19, 2015: Nature
https://www.readbyqxmd.com/read/25343965/a-systematic-analysis-of-the-in-vitro-and-in-vivo-functions-of-the-hd-gyp-domain-proteins-of-vibrio-cholerae
#20
Robert W McKee, Ankunda Kariisa, Benjamin Mudrak, Courtney Whitaker, Rita Tamayo
BACKGROUND: The second messenger cyclic diguanylate (c-di-GMP) plays a central role in bacterial adaptation to extracellular stimuli, controlling processes such as motility, biofilm development, cell development and, in some pathogens, virulence. The intracellular level of c-di-GMP is controlled by the complementary activities of diguanylate cyclases containing a GGDEF domain and two classes of c-di-GMP phosphodiesterases containing an EAL or HD-GYP hydrolytic domain. Compared to the GGDEF and EAL domains, the functions of HD-GYP domain family proteins are poorly characterized...
2014: BMC Microbiology
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