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https://www.readbyqxmd.com/read/28539008/position-in-the-second-stage-of-labour-for-women-without-epidural-anaesthesia
#1
REVIEW
Janesh K Gupta, Akanksha Sood, G Justus Hofmeyr, Joshua P Vogel
BACKGROUND: For centuries, there has been controversy around whether being upright (sitting, birthing stools, chairs, squatting, kneeling) or lying down (lateral (Sim's) position, semi-recumbent, lithotomy position, Trendelenburg's position) have advantages for women giving birth to their babies. This is an update of a review previously published in 2012, 2004 and 1999. OBJECTIVES: To determine the possible benefits and risks of the use of different birth positions during the second stage of labour without epidural anaesthesia, on maternal, fetal, neonatal and caregiver outcomes...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28538845/-spatial-analysis-of-gestational-anemia-in-peru-2015
#2
Akram Hernández-Vásquez, Diego Azañedo, Daniel A Antiporta, Sandra Cortés
Objectives: To establish regional prevalences of anemia in pregnant women receiving care at public clinics in Peru in 2015 and identify high-prevalence district conglomerates. Materials and Methods: An ecological study was carried out on data from pregnant women with anemia registered on the Nutritional Status Information System (SIEN) who received care in 7703 public clinics in 2015. Regional and district prevalences of gestational anemia were calculated. District conglomerates with a high prevalence of gestational anemia were identified using the Moran Index...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538795/neonatal-near-miss-and-mortality-factors-associated-with-life-threatening-conditions-in-newborns-at-six-public-maternity-hospitals-in-southeast-brazil
#3
Pauline Lorena Kale, Maria Helena Prado de Mello-Jorge, Kátia Silveira da Silva, Sandra Costa Fonseca
We aimed to evaluate factors associated with cases of neonatal near miss and neonatal deaths at six public maternity hospitals in São Paulo and Rio de Janeiro States, Brazil, in 2011. A prospective hospital-based birth cohort investigated these outcomes among live births with life-threatening conditions. Associations were tested using multinomial logistic regression models with hierarchical levels. High rates of near miss were observed for maternal syphilis (52.2‰ live births) and lack of prenatal care (80...
May 18, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28538740/periodontal-status-during-pregnancy-and-postpartum
#4
Maximino González-Jaranay, Luís Téllez, Antonio Roa-López, Gerardo Gómez-Moreno, Gerardo Moreu
OBJECTIVES: Different studies have documented an association between periodontal disease and low birth-weight delivery. Hence, knowledge of periodontal status during pregnancy and postpartum is important in order to reduce the risks of both diseases. This study aimed to analyze periodontal status at successive stages of pregnancy and 3-6 weeks postpartum in women with initial periodontal alterations. MATERIALS AND METHODS: Ninety-six pregnant women were examined at 8-10 weeks (pregnancy diagnosis, baseline), 21-23 weeks and 34-36 weeks of gestation and at 40 days postpartum to record plaque scores, clinically assessed gingival inflammation and probing depth (mean depth and % sites with depth >3 mm)...
2017: PloS One
https://www.readbyqxmd.com/read/28538696/immune-components-in-human-milk-are-associated-with-early-infant-immunological-health-outcomes-a-prospective-three-country-analysis
#5
Daniel Munblit, Marina Treneva, Diego G Peroni, Silvia Colicino, Li Yan Chow, Shobana Dissanayeke, Alexander Pampura, Attilio L Boner, Donna T Geddes, Robert J Boyle, John O Warner
The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature milk and infant outcomes in the first year of life. In a large prospective study of 398 pregnant/lactating women in the United Kingdom, Russia and Italy, colostrum and mature human milk (HM) samples were analysed for immune active molecules...
May 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28538390/decreased-cord-blood-estradiol-levels-in-related-to-mothers-with-gestational-diabetes
#6
Xiuyu Qi, Bo Gong, Jing Yu, Limin Shen, Wanling Jin, Zhenmin Wu, Jieyun Wang, Jie Wang, Zhiqi Li
Recent studies have revealed a link between estradiol (E2) and glucose homeostasis. We aimed to assess the association between cord blood hormone levels and the risk of gestational diabetes mellitus (GDM).A total of 204 pregnant women with GDM and 204 pregnant women without GDM (control) were included in the study. Maternal GDM were diagnosed using a 75 g oral glucose tolerance test at 24 to 26 weeks of gestation. Cord blood samples from neonates were collected immediately post delivery. Controls, which were randomly selected from the study population, were matched (cases to controls ratio: 1:1) to cases by age, sex of fetus, and gestational week...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538223/which-fetal-pelvic-variables-are-useful-for-predicting-caesarean-section-and-instrumental-assistance
#7
Pierre Frémondière, Lionel Thollon, Pascal Adalian, Jérôme Delotte, François Marchal
OBJECTIVE: To assess the variables useful to predict caesarean delivery and instrumental assistance, through the analysis of a large number of fetal-pelvic variables, using discriminant analysis. MATERIALS AND METHODS: One hundred and fourteen (114) pregnant women were included in this single center prospective study. For each mother-fetus pair, 43 pelvic and 18 fetal variables were measured. Partial Least Squares Discriminate Analyses were performed to identify fetal-pelvic variables that could statistically separate the three delivery modality groups: spontaneous vaginal delivery, caesarean delivery and instrument assisted delivery...
May 23, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28537936/zidovudine-use-in-pregnancy-and-congenital-malformations-meta-analysis-and-bayesian-incorporation-of-medicaid-data
#8
Kathryn Rough, Jenny W Sun, George R Seage, Paige L Williams, Krista F Huybrechts, Brian T Bateman, Sonia Hernandez-Diaz
OBJECTIVE: There is inconsistent evidence that zidovudine use during pregnancy increases overall, cardiac, and male genital malformations. DESIGN: We conducted a systematic review and meta-analysis of zidovudine use and malformations and, using Bayesian methods, combined it with data from a cohort study of mother-infant pairs in the nationwide Medicaid Analytic eXtract (MAX). METHODS: Using MAX data (2000-2010), we identified pregnant women with HIV treated with antiretroviral therapy (ART)...
May 23, 2017: AIDS
https://www.readbyqxmd.com/read/28537755/a-pilot-study-of-noninvasive-prenatal-diagnosis-of-alpha-and-beta-thalassemia-with-target-capture-sequencing-of-cell-free-fetal-dna-in-maternal-blood
#9
Wenjuan Wang, Yuan Yuan, Haiqing Zheng, Yaoshen Wang, Dan Zeng, Yihua Yang, Xin Yi, Yang Xia, Chunjiang Zhu
AIMS: Thalassemia is a dangerous hematolytic genetic disease. In south China, ∼24% Chinese carry alpha-thalassemia or beta-thalassemia gene mutations. Given the fact that the invasive sampling procedures can only be performed by professionals in experienced centers, it may increase the risk of miscarriage or infection. Thus, most people are worried about the invasive operation. As such, a noninvasive and accurate prenatal diagnosis is needed for appropriate genetic counseling for families with high risks...
May 24, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28535184/maternal-zika-virus-disease-severity-virus-load-prior-dengue-antibodies-and-their-relationship-to-birth-outcomes
#10
U A Halai, K Nielsen-Saines, M E Moreira, P C Sequeira, J P Pereira Junior, A A Zin, J D Cherry, C R Gabaglia, S L Gaw, K Adachi, I Tsui, J H Pilotto, R M Ribeiro Nogueira, A M Bispo de Filippis, P Brasil
Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection...
May 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28534997/reduced-expression-of-follicle-stimulating-hormone-receptor-mrna-and-protein-in-pregnancies-complicated-by-pre%C3%A2-eclampsia
#11
Mo Li, Yifan Jia, Yan Ling, Yilu Chen, Lu Zhang, Dan Luo, Lidan Lai, Meijun Guo, Dalei Zhang, Min Ren, Hong Xu, Haibin Kuang
Expression and function of the follicle‑stimulating hormone receptor (FSHR) are traditionally thought to be limited to the ovary in females. However, recent studies have indicated that the FSHR is also expressed in endothelial cells of the placental vasculature, and that the haploinsufficiency of the feto‑placental FSHR impaired the growth of the mouse placenta. The aim of the current study was to investigate the placental expression of FSH and FSHR in pregnancies complicated by pre‑eclampsia. Placental tissue samples were collected from 20 pregnancies with pre‑eclampsia and 25 normal pregnancies...
May 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534828/how-ketamine-affects-livers-of-pregnant-mice-and-developing-mice
#12
Hoi Man Cheung, Tony Chin Hung Chow, David Tai Wai Yew
It is well known that ketamine abuse can induce liver damage in adult addicts, but the effects of ketamine abuse in pregnant mothers on their offspring have received less attention. In this study, we investigated the effects of 5-day ketamine injections (30 mg/kg) to pregnant Institute for Cancer Research (ICR) mice during early gestation or mid-gestation on the aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of the mothers and the offspring. We also looked into whether administering ketamine treatment to the mothers had any effects on the extent of fibrosis, cell proliferation and cell death in the livers of the newborns...
May 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28534711/expressions-of-irisin-and-urotensin-ii-and-their-relationships-with-blood-pressure-in-patients-with-preeclampsia
#13
Li-Jie Zhang, Qian Xie, Chao-Shu Tang, Ai-Hua Zhang
The aims of this study are to observe irisin and urotensin II (UII) levels in serum and placenta in normal pregnant and preeclamptic women and investigate the relationship between expressions irisin and UII, and their association with blood pressure. A total of 67 pregnant subjects were recruited, including 31 healthy and 36 preeclamptic pregnant women. Serum irisin and UII concentrations were measured. Expressions of fibronectin type III domain-containing protein 5 (FNDC5) (irisin precursor) and UII in placenta specimens were performed...
May 23, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28534450/population-estimate-and-morphometry-of-ovarian-preantral-follicles-from-three-recently-recognized-squirrel-monkey-species-a-comparative-study
#14
Gerson P Lopes, Regiane R Santos, Débora V Almeida, Adriel B Brito, Helder L Queiroz, Sheyla F S Domingues
We describe morphological and morphometrical characteristics of preantral ovarian follicles from three recently recognized Saimiri species: S. macrodon, S. cassiquiarensis and S. vanzolinii; the last one a threatened species. Ovaries from four adult monkeys were evaluated: one pair from a pregnant S. macrodon, two ovarian pairs from S. cassiquiarensis females (one of them pregnant), and one left ovary from a senile S. vanzolinii, applying classical histology. Follicular preantral population was quantified and morphology and morphometry of primordial, primary and secondary follicles were evaluated...
May 23, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28534220/is-decompressive-surgery-the-only-treatment-option-a-case-series-of-patients-with-spinal-tuberculosis-in-advanced-pregnancy
#15
Ashok K Rathod, Vishwajeet Singh, Prateek Patil, Hemant Singh
PURPOSE: To present cases of spinal tuberculosis in advanced pregnancy treated on anti-tuberculous drug regimen with successful outcome and proposing alternative paradigm to surgical decompression. A case series of five patients in stages of advanced pregnancy with neurologic deterioration and spinal tuberculosis were reported and treated. METHODS: Five patients with backache in advanced stages of pregnancy were reported. Patients were diagnosed as cases of spinal tuberculosis on further imaging studies...
May 22, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28534013/serum-from-pregnant-women-with-gestational-diabetes-mellitus-increases-the-expression-of-fabp4-mrna-in-primary-subcutaneous-human-pre-adipocytes
#16
Lan Li, Se Jin Lee, Song Yi Kook, Tae Gyu Ahn, Ji Yeon Lee, Jong Yun Hwang
OBJECTIVE: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. The aim of this study was to investigate whether FABP4 in the placenta and decidua of pregnant women with GDM is higher than that in normal pregnant women, and whether serum from pregnant women with GDM may cause adipocytes to secrete more FABP4 than does serum from a normal pregnant group...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28533844/utility-of-first-trimester-obstetric-ultrasonography-before-13-weeks-of-gestation-a-retrospective-study
#17
Felix Uduma Uduma, Anelkan Abaslattai, Dianabasi Udoete Eduwem, Morgan Ekanem, Philip Chinedu Okere
INTRODUCTION: First trimester pregnancy is defined as twelve weeks after the last menstrual period. Ultrasonography has revolutionized validation and management of first trimester pregnancies. The aim was to analyze ultrasonographic findings of first trimester pregnancies in University of Uyo teaching hospital (UUTH), Uyo, Nigeria. METHODS: The departmental ultrasonographic records of pregnant women who were referred to Radiology department of UUTH, Uyo, Nigeria...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533734/gene-expression-profiling-associated-with-hepatoxicity-in-pregnant-rats-treated-with-ubi-gadong-dioscorea-hispida-extract
#18
Ezarul Faradianna Lokman, Hussin Muhammad, Norizah Awang, Maizatul Hasyima Omar, Fazliana Mansor, Fatin Saparuddin
Dioscorea hispida (D.hispida) is the most well-known starchy tuber in Malaysia and called 'ubi gadong'. Despite concerns over toxicity effects, the tuber is known to possess therapeutic values due to the presence of bioactive compounds such as saponins. This study was performed to identify the changes in gene expression profiles associated with hepatoxicity in pregnant rat treated with D.hispida using RT² Profiler PCR Array. The identification of steroidal saponins from D.hispida was carried out by UHPLC/MS method...
March 2017: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/28533699/comparative-analysis-of-the-safety-and-tolerability-of-fixed-dose-artesunate-amodiaquine-versus-artemether-lumefantrine-combinations-for-uncomplicated-falciparum-malaria-in-pregnancy-a-randomized-open-label-study
#19
Osede I Iribhogbe, Igue Emmanuel, Marylove Odianosen
A comparative clinical study was conducted to evaluate the safety and tolerability of two commonly used fixed dose artemisinin-based combinations for the treatment of uncomplicated Plasmodium falciparum malaria in the second and third trimester of pregnancy. To achieve this, a total of 155 participants were recruited for the study. Eighty of these were drawn from pregnant women who came for routine antenatal care while 40 nonpregnant participants were recruited from apparently healthy females in the community...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28533136/effect-of-artificial-pancreas-systems-on-glycaemic-control-in-patients-with-type-1-diabetes-a-systematic-review-and-meta-analysis-of-outpatient-randomised-controlled-trials
#20
Alanna Weisman, Johnny-Wei Bai, Marina Cardinez, Caroline K Kramer, Bruce A Perkins
BACKGROUND: Closed-loop artificial pancreas systems have been in development for several years, including assessment in numerous varied outpatient clinical trials. We aimed to summarise the efficacy and safety of artificial pancreas systems in outpatient settings and explore the clinical and technical factors that can affect their performance. METHODS: We did a systematic review and meta-analysis of randomised controlled trials comparing artificial pancreas systems (insulin only or insulin plus glucagon) with conventional pump therapy (continuous subcutaneous insulin infusion [CSII] with blinded continuous glucose monitoring [CGM] or unblinded sensor-augmented pump [SAP] therapy) in adults and children with type 1 diabetes...
May 19, 2017: Lancet Diabetes & Endocrinology
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