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Hexokinase 2

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https://www.readbyqxmd.com/read/29777095/butein-inhibited-in-vitro-hexokinase-2-mediated-tumor-glycolysis-in-hepatocellular-carcinoma-by-blocking-epidermal-growth-factor-receptor-egfr
#1
Weirong Liao, Jingtian Liu, Dawei Zhang, Wenhai Huang, Runhao Chen
BACKGROUND Anaerobic glycolysis is an important physiological process of all cancer cells. Butein has been reported to demonstrate substantial antitumor activities in various cancers. However, the effect of butein on tumor glycolysis remains unclear. In this study, the effect of butein on tumor glycolysis and the underlying mechanism were investigated in hepatocellular carcinoma (HCC). MATERIAL AND METHODS Cell proliferation assay and anchorage-independent growth assay were carried out to evaluate the antitumor activities of butein in vitro...
May 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29764240/ferrous-glycinate-regulates-cell-energy-metabolism-by-restricting-hypoxia-induced-factor-1%C3%AE-expression-in-human-a549-cells
#2
Yung-Ting Kuo, Jhong-Huei Jheng, Mei-Chen Lo, Wei-Lu Chen, Shyang-Guang Wang, Horng-Mo Lee
Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein levels of HIF-1α, which was abrogated by proteosome inhibitor, or prolyl hydroxylase inhibitor. Addition of ferrous glycinate decreased protein levels of glucose transporter-1, hexokinase-2, and lactate dehydrogenase A, and decreased pyruvate dehydrogenase kinase-1 (PDK-1) and pyruvate dehydrogenase (PDH) phosphorylation in A549 cells...
May 15, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29763606/mir-216a-5p-hexokinase-2-axis-regulates-uveal-melanoma-growth-through-modulation-of-warburg-effect
#3
Ying Liu, Yan Huo, Dajiang Wang, Yanhong Tai, Jie Li, Dongbo Pang, Yan Zhang, Wei Zhao, Nan Du, Yifei Huang
Hexokinase-2 (HK2), the initial as well as the rate-limiting step in glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its enzymes, including HK2, are being developed. However, the mechanisms of HK2 inhibition and the physiological significance of the HK2 inhibitors in cancer cells are rarely reported. Here, we show that microRNA-216a-5p (miR-216a-5p) inhibits HK2 expression by directly targeting its 3'-UTR in uveal melanoma cells...
May 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29735421/3-bromopyruvate-reverses-hypoxia-induced-pulmonary-arterial-hypertension-through-inhibiting-glycolysis-in-vitro-and-in-vivo-studies
#4
Fangzheng Chen, Heng Wang, Jiadan Lai, Shujing Cai, Linbo Yuan
BACKGROUND: Pulmonary arterial smooth muscle cell (PASMC) proliferation is vital to pulmonary vascular remodeling in pulmonary arterial hypertension (PAH) pathogenesis, and inhibiting PASMC metabolism could serve as a new possible therapy to reverse the process. 3-Bromopyruvate (3-BrPA) is an effective glycolysis inhibitor with its effect in PAH remains unclear. Our study aims to assess the therapeutic effect of 3-BrPA in PAH rats and investigate the possible mechanism of 3-BrPA in PASMC proliferation and apoptosis...
May 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29721175/the-decrease-of-glycolytic-enzyme-hexokinase-1-accelerates-tumor-malignancy-via-deregulating-energy-metabolism-but-sensitizes-cancer-cells-to-2-deoxyglucose-inhibition
#5
Po-Lin Tseng, Chih-Wei Chen, Keng-Hsun Hu, Hung-Chi Cheng, Yuan-Ho Lin, Wen-Hui Tsai, Tain-Junn Cheng, Wei-Hsuan Wu, Chin-Wei Yeh, Chin-Chih Lin, Hui-Ju Tsai, Hao-Chun Chang, Jiin-Haur Chuang, Yan-Shen Shan, Wen-Tsan Chang
Malignant tumors often display an aberrant energy metabolism that relies primarily on glycolysis to produce adenosine triphosphate (ATP) the so-called Warburg effect or aerobic glycolysis. Thus, the elucidation of this energetic alteration in malignant tumors is important in the search for more effective therapeutics against malignant cancers, the most deadly human disease. To investigate whether attenuated glycolytic activity modulates tumor progression, the effects of silencing the first and rate-limiting glycolytic enzyme hexokinase (HK) isozymes HK1 and HK2 were examined...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29710658/guava-leaf-inhibits-hepatic-gluconeogenesis-and-increases-glycogen-synthesis-via-ampk-acc-signaling-pathways-in-streptozotocin-induced-diabetic-rats
#6
Ramachandran Vinayagam, Muthukumaran Jayachandran, Stephen Sum Man Chung, Baojun Xu
Psidium guajava (PG) is a short shrub or tree cultivated in tropical and subtropical regions around the world. The leaf extract of PG (guava leaf) has been used historically to cure many ailments. However, mechanisms of action of guava leaf in treating diabetes are not fully understood. Effects and underlying mechanisms of guava leaf on gluconeogenesis and glycogenesis in hepatocytes, insulin signaling proteins, liver function markers, and lipid profile in streptozotocin (STZ) injected diabetic Wistar rats were investigated within the current study...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29698587/selective-induction-of-cancer-cell-death-by-vdac1-based-peptides-and-their-potential-use-in-cancer-therapy
#7
Anna Shteinfer-Kuzmine, Zohar Amsalem, Tasleem Arif, Alexandra Zooravlov, Varda Shoshan-Barmatz
Mitochondrial VDAC1 mediates cross-talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+ and metabolites, and serves as a key player in apoptosis. As such, VDAC1 is involved in two important hallmarks of cancer development, namely energy and metabolic reprograming and apoptotic cell death evasion. We previously developed cell-penetrating VDAC1-derived peptides that interact with hexokinase (HK), Bcl-2 and Bcl-xL to prevent the anti-apoptotic activities of these proteins and induce cancer cell death, with a focus on leukemia and glioblastoma...
April 26, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29696133/classical-nf-%C3%AE%C2%BAb-metabolically-reprograms-sarcoma-cells-through-regulation-of-hexokinase-2
#8
Priya Londhe, Peter Y Yu, Yuichi Ijiri, Katherine J Ladner, Joelle M Fenger, Cheryl London, Peter J Houghton, Denis C Guttridge
Background: Metabolic reprogramming has emerged as a cancer hallmark, and one of the well-known cancer-associated metabolic alterations is the increase in the rate of glycolysis. Recent reports have shown that both the classical and alternative signaling pathways of nuclear factor κB (NF-κB) play important roles in controlling the metabolic profiles of normal cells and cancer cells. However, how these signaling pathways affect the metabolism of sarcomas, specifically rhabdomyosarcoma (RMS) and osteosarcoma (OS), has not been characterized...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29679350/alleviation-mechanisms-of-selenium-on-cadmium-spiked-in-chicken-ovarian-tissue-perspectives-from-autophagy-and-energy-metabolism
#9
Shuang Wang, Zhe Xu, Hang Yin, Yahong Min, Shu Li
Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Administration of Cd for 12 weeks led to energy metabolism disorder of the chicken ovarian tissues, which resulted in autophagy. In addition, the mRNA expression of glucose-related genes including hexokinase II (HK2), pyruvate kinase (PK), pyruvate dehydrogenase complex (PDHX), and succinate dehydrogenase (SDH) and the activities of ATPase, including Na+ -K+ -ATPase, Ca2+ -ATPase, Mg2+ -ATPase, were all downregulated remarkably compared with the control...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#10
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29673674/association-between-18f-fluorodeoxyglucose-pet-ct-and-histological-grade-of-uterine-endometrial-carcinoma
#11
Hiroaki Takagi, Toshiyuki Sasagawa, Takeo Shibata, Hiroshi Minato, Tomoko Takahashi
OBJECTIVE: The incidence of endometrial adenocarcinoma of the uterine corpus has increased in Japan. This study aimed to clarify the relationships between this type of cancer and various data provided by 18F-fluorodeoxyglucose (FDG) accumulation in positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: The study cohort thus comprised 27 patients with endometrial adenocarcinoma who had undergone PET/CT examinations from April 2008 to March 2015...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29663500/knockdown-of-lncrna-uca1-suppresses-chemoresistance-of-pediatric-aml-by-inhibiting-glycolysis-through-the-microrna-125a-hexokinase-2-pathway
#12
Yuan Zhang, Yufeng Liu, Xueju Xu
Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression in AML patients after adriamycin (ADR)-based chemotherapy and ADR-resistant AML cells was examined by qRT-PCR. The effects of UCA1 on the cytotoxicity of ADR and glycolysis were evaluated by MTT assay and measuring the glucose consumption and lactate production in HL60 and HL60/ADR cells, repectively...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29644447/genome-wide-identification-of-hexokinase-gene-family-in-brassica-napus-structure-phylogenetic-analysis-expression-and-functional-characterization
#13
Jingxue Wang, Xiaoming Wang, Siyu Geng, Sanjay K Singh, Yaohui Wang, Sitakanta Pattanaik, Ling Yuan
Genome-wide identification, expression analysis, and functional characterization of previously uncharacterized hexokinase family of oil crop, Brassica napus, underscore the importance of this gene family in plant growth and development. In plants, the multi-gene family of dual-function hexokinases (HXKs) plays important roles in sugar metabolism and sensing that affect growth and development. Rapeseed (Brassica napus L.) is an important oil crop; however, little is known about the B. napus HXK gene family...
April 11, 2018: Planta
https://www.readbyqxmd.com/read/29573521/activation-of-the-igf1-receptor-stimulates-glycogen-synthesis-by-mink-uterine-epithelial-cells
#14
Matthew Dean, Jack Rose
Glycogen synthesis by mink uterine epithelial cells is stimulated by estradiol (E2 ) during estrus, although the mechanism/s through which the steroid promotes glycogen accumulation are unknown. Our aim was to determine if insulin is required for E2 induced glycogen synthesis by an immortalized mink uterine epithelial cell line (GMMe). We show that the cells expressed the genes for glycogen metabolizing enzymes (hexokinase 1, glucose-6-phosphatase 3, glycogen synthase 1 and glycogen phosphorylase-muscle), receptors for insulin, insulin-like growth factor 1 and E2 (Esr1)...
March 24, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29566785/temporally-differential-protein-expression-of-glycolytic-and-glycogenic-enzymes-during-in-vitro-preimplantation-bovine-embryo-development
#15
Manuel García-Herreros, Constantine A Simintiras, Patrick Lonergan
Proteomic analyses are useful for understanding the metabolic pathways governing embryo development. This study investigated the presence of enzymes involved in glycolysis and glycogenesis in in vitro-produced bovine embryos at five developmental stages leading up to blastocyst formation. The enzymes examined were: (1) glycolytic: hexokinase-I (HK-I), phosphofructokinase-1 (PFK-1), pyruvate kinase mutase 1/2 (PKM-1/2), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and (2) glycogenic: glycogen synthase kinase-3 isoforms α/ β (GSK-3α/β)...
March 23, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29559564/overexpression-of-mir-202-re-sensitizes-imatinib-resistant-chronic-myeloid-leukemia-cells-through-targeting-hexokinase-2-hk2
#16
Yingjun Deng, Xin Li, Jinxin Feng, Xiangliang Zhang
CML is a myeloproliferative disease which expresses an active tyrosine kinase, BCR/ABL. As a specific inhibitor of BCR-ABL tyrosine kinase, imatinib becomes the first choice for treatment of CML due to its high efficacy and low toxicity. However, the development of imatinib resistance limits the long-term treatment benefit. so, we aimed to investigate the roles of miR-202 in the regulation of imatinib sensitivity in CML cell lines and the possible mechanisms involved. We found miR-202 was downregulated in seven CML cell lines by qRT-PCR analysis...
March 20, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29554146/evaluation-of-classical-and-novel-autoantibodies-for-the-diagnosis-of-primary-biliary-cholangitis-autoimmune-hepatitis-overlap-syndrome-pbc-aih-os
#17
Henry H Nguyen, Abdel Aziz Shaheen, Natalia Baeza, Ellina Lytvyak, Stefan J Urbanski, Andrew L Mason, Gary L Norman, Marvin J Fritzler, Mark G Swain
BACKGROUND AND AIMS: Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH overlap syndrome (PBC-AIH OS) have been reported to exhibit suboptimal responses to ursodeoxycholic acid therapy, and are more likely to progress to cirrhosis. Anti-double stranded DNA (anti-dsDNA) and anti-p53 have been previously suggested to be potential autoantibodies for identifying patients with PBC-AIH OS...
2018: PloS One
https://www.readbyqxmd.com/read/29552193/effect-of-hk2-pkm2-and-ldha-on-cetuximab-efficacy-in-metastatic-colorectal-cancer
#18
Haohua Wang, Roujun Peng, Xiuxing Chen, Rui Jia, Chunyue Huang, Yuanyuan Huang, Liangping Xia, Guifang Guo
Although hexokinase (HK) 2, pyruvate kinase muscle (PKM) isozyme 2 and lactate dehydrogenase (LDH) A predict the efficacy of medicines in various solid tumors, their ability to predict the efficacy of cetuximab in metastatic colorectal cancer (mCRC) remains unclear. mCRC patients with pathological specimens who received cetuximab and chemotherapy from 2005 to 2015 in the present institution were enrolled. Immunohistochemistry was used to detect HK2, PKM2 and LDHA expression. SPSS20 was used for statistical analysis...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29545180/hepatic-glucose-6-phosphatase-%C3%AE-deficiency-leads-to-metabolic-reprogramming-in-glycogen-storage-disease-type-ia
#19
Jun-Ho Cho, Goo-Young Kim, Brian C Mansfield, Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in endogenous glucose production. This autosomal recessive disorder is characterized by impaired glucose homeostasis and long-term complications of hepatocellular adenoma/carcinoma (HCA/HCC). We have shown that hepatic G6Pase-α deficiency-mediated steatosis leads to defective autophagy that is frequently associated with carcinogenesis. We now show that hepatic G6Pase-α deficiency also leads to enhancement of hepatic glycolysis and hexose monophosphate shunt (HMS) that can contribute to hepatocarcinogenesis...
March 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29523440/mitochondria-endoplasmic-reticulum-contact-sites-function-as-immunometabolic-hubs-that-orchestrate-the-rapid-recall-response-of-memory-cd8-t-cells
#20
Glenn R Bantug, Marco Fischer, Jasmin Grählert, Maria L Balmer, Gunhild Unterstab, Leyla Develioglu, Rebekah Steiner, Lianjun Zhang, Ana S H Costa, Patrick M Gubser, Anne-Valérie Burgener, Ursula Sauder, Jordan Löliger, Réka Belle, Sarah Dimeloe, Jonas Lötscher, Annaïse Jauch, Mike Recher, Gideon Hönger, Michael N Hall, Pedro Romero, Christian Frezza, Christoph Hess
Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 (mTORC2) led to inhibition of glycogen synthase kinase 3β (GSK3β) at mitochondria-endoplasmic reticulum (ER) junctions. This enabled recruitment of hexokinase I (HK-I) to the voltage-dependent anion channel (VDAC) on mitochondria...
March 20, 2018: Immunity
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