keyword
https://read.qxmd.com/read/38396948/the-interaction-of-the-endocannabinoid-anandamide-and-paracannabinoid-lysophosphatidylinositol-during-cell-death-induction-in-human-breast-cancer-cells
#21
JOURNAL ARTICLE
Mikhail G Akimov, Natalia M Gretskaya, Evgenia I Gorbacheva, Nisreen Khadour, Valeria S Chernavskaya, Galina D Sherstyanykh, Tatiana F Kovaleko, Elena V Fomina-Ageeva, Vladimir V Bezuglov
Endocannabinoid anandamide (AEA) and paracannabinoid lysophosphatidylinositol (LPI) play a significant role in cancer cell proliferation regulation. While anandamide inhibits the proliferation of cancer cells, LPI is known as a cancer stimulant. Despite the known endocannabinoid receptor crosstalk and simultaneous presence in the cancer microenvironment of both molecules, their combined activity has never been studied. We evaluated the effect of LPI on the AEA activity in six human breast cancer cell lines of different carcinogenicity (MCF-10A, MCF-7, BT-474, BT-20, SK-BR-3, MDA-MB-231) using resazurin and LDH tests after a 72 h incubation...
February 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38390262/identification-of-c-plan-index-as-a-novel-prognostic-predictor-for-advanced-lung-cancer-patients-receiving-immune-checkpoint-inhibitors
#22
JOURNAL ARTICLE
Jiaxin Wang, Huaijuan Guo, Jingjing Yang, Jingxian Mao, Ying Wang, Xuebing Yan, Hong Guo
OBJECTIVE: Increasing studies have highlighted the potential utility of non-invasive prognostic biomarkers in advanced lung cancer patients receiving immune checkpoint inhibitor (ICI) based anti-cancer therapies. Here, a novel prognostic predictor named as C-PLAN integrating C-reactive protein (CRP), Performance status (PS), Lactate dehydrogenase (LDH), Albumin (ALB), and derived Neutrophil-to-lymphocyte ratio (dNLR) was identified and validated in a single-center retrospective cohort...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38387915/-efficacy-and-safety-of-bortezomib-or-thalidomide-combined-with-rhepo-in-the-treatment-of-multiple-myeloma
#23
JOURNAL ARTICLE
Zhao-Ling Zou, Xiao-Hua Wang, Sheng-Neng Tao, Zhi-Ming Cheng
OBJECTIVE: To explore the efficacy and safety of bortezomib or thalidomide combined with recombinant human erythropoietin (rhEPO) in the treatment of multiple myeloma (MM). METHODS: A total of 80 patients with MM who were treated in the Second People's Hospital of Wuhu from January 2013 to December 2018 were selected as the research subjects, and they were divided into bortezomib group ( n =40) and thalidomide group ( n =40) by the simple randomization method. The bortezomib group received bortezomib regimen combined with rhEPO therapy, and the thalidomide group was given thalidomide regimen combined with rhEPO therapy, and all patients were treated for 3 courses with every 3 weeks as a course of treatment...
February 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38379641/case-report-thrombotic-thrombocytopenic-purpura-in-a-pregnant-woman-with-lupus-membranous-nephropathy-a-diagnostic-challenge
#24
Marina Leiva, Gustavo Navarro, J Daniel Carpio, Leopoldo Ardiles
A 27-year-old female at 20th week of pregnancy was admitted with edema, foamy urine, but normal blood pressure. Her blood count was normal, she had proteinuria of 3 g/day, creatinine 0.4 mg/dl, albumin 2.4 g/dl, and cholesterol 355 mg/dl. Antinuclear antibodies 1/160, but Anti-DNA, anticardiolipin antibodies and lupus anticoagulant were negative, with normal serum C3 and C4. A renal biopsy showed secondary membranous glomerulopathy, most likely lupus class V pure. Steroids, azathioprine, and aspirin were initiated, up to 28 weeks of pregnancy, when she developed severe hypertension, photopsia, headache, anasarca, extensive bruising of the extremities, severe anemia, thrombocytopenia, and creatinine rose to 2...
2024: Front Nephrol
https://read.qxmd.com/read/38366709/isoliquiritigenin-inhibits-nlrp3-inflammasome-activation-with-caps-mutations-by-suppressing-caspase-1-activation-and-mutated-nlrp3-aggregation
#25
JOURNAL ARTICLE
Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai
The nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome contributes to the development of inflammatory diseases. Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by NLRP3 gene mutations that results in excessive IL-1β production. We previously identified isoliquiritigenin (ILG), a component of Glycyrrhiza uralensis extracts, as a potent inhibitor of the NLRP3 inflammasome. Here, we aimed to investigate whether ILG inhibits the activation of NLRP3 inflammasome caused by NLRP3 gene mutations...
February 17, 2024: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://read.qxmd.com/read/38357976/tetramethylpyrazine-attenuates-renal-tubular-epithelial-cell-ferroptosis-in-contrast-induced-nephropathy-by-inhibiting-transferrin-receptor-and-intracellular-reactive-oxygen-species
#26
JOURNAL ARTICLE
Zhongqiang Zhu, Jun Li, Zhiyong Zhi Song, Tonglu Tong Li, Zongping Zong Li, Xuezhong Gong
Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). Recently ferroptosis was reported to be crucial for AKI pathogenesis. Our previous studies indicated antioxidant tetramethylpyrazine (TMP) prevent CIN in vivo. However, whether ferroptosis is involved in TMP nephroprotective mechanism against CIN is unclear. In present study we investigated the role of renal tubular epithelial cell ferroptosis in TMP reno-protective effect against CIN and the molecular mechanisms by which TMP regulates ferroptosis...
February 14, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38353878/melatonin-antagonizes-oxidative-stress-induced-apoptosis-in-retinal-ganglion-cells-through-activating-the-thioredoxin-1-pathway
#27
JOURNAL ARTICLE
Shan Gao, Qiaochu Cheng, Yaguang Hu, Xiaojuan Fan, Chen Liang, Chen Niu, Qianyan Kang, Ting Wei
This study aimed to explore the role of melatonin in oxidative stress-induced injury on retinal ganglion cells and the underlying mechanisms. The immortalized RGC-5 cells were treated with H2 O2 to induce oxidative injury. Cell viability was measured by Cell Counting Kit-8, and apoptosis was determined by flow cytometry and western blot assays. Reactive oxygen species (ROS), lactate dehydrogenase (LDH), and malondialdehyde (MDA) levels were examined to evaluate oxidative stress levels. In addition, Thioredoxin-1 (Trx1) was silenced in RGC-5 cells using small interfering RNA followed by signaling pathway examination to explore the underlying mechanisms of melatonin in alleviating oxidative injury...
February 14, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38348608/real-world-experience-of-pegcetacoplan-in-paroxysmal-nocturnal-hemoglobinuria
#28
JOURNAL ARTICLE
Morag Griffin, Richard Kelly, Isabelle Brindel, Lynda Maafa, Roochi Trikha, Petra Muus, Talha Munir, Abraham Mullasseril Varghese, Lindsay Mitchell, Sateesh Nagumantry, Shreyans Gandhi, Alex Pike, Austin G Kulasekararaj, Regis Peffault de Latour
Pegcetacoplan significantly improves outcomes for patients with paroxysmal nocturnal hemoglobinuria (PNH) experiencing extravascular hemolysis (EVH) on eculizumab, leading to approval in 2021/2022 (USA/Europe). We report the first collaborative real-world evidence on pegcetacoplan use in UK and France. A total of 48 patients were either currently receiving or previously received pegcetacoplan (2019-2023). A total of 12 patients had participated in the PEGASUS clinical trial, continuing treatment after trial completion...
February 13, 2024: American Journal of Hematology
https://read.qxmd.com/read/38346469/parp-1-inhibitor-alleviates-cerebral-ischemia-reperfusion-injury-by-reducing-parylation-of-hk-1-and-ldh-in-mice
#29
JOURNAL ARTICLE
Ya-Ling Chen, Yi Wang, Qiu-Yu Fang, Tong Wang, Cong Chen, Tong-Yao Gao, Ming Wu, Wei-Ping Zhang, Yun-Bi Lu
Poly (ADP-ribose) polymerase-1 (PARP-1) activity significantly increases during cerebral ischemia/reperfusion. PARP-1 is an NAD+ -consumption enzyme. PARP-1 hyperactivity causes intracellular NAD+ deficiency and bioenergetic collapse, contributing to neuronal death. Besides, the powerful trigger of PARP-1 causes the catalyzation of poly (ADP-ribosyl)ation (PARylation), a posttranslational modification of proteins. Here, we found that PARP-1 was activated in the ischemic brain tissue during middle-cerebral-artery occlusion and reperfusion (MCAO/R) for 24 h, and PAR accumulated in the neurons in mice...
February 10, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38346456/mscs-derived-exosomes-containing-mir-486-5p-attenuate-cerebral-ischemia-and-reperfusion-i-r-injury
#30
JOURNAL ARTICLE
Genbao Zhu, La Jiang, Kemeng Tan, Yafen Li, Mengxue Hu, Shengnan Zhang, Zhenlin Liu, Lili Li
OBJECTIVES: This study aims to investigate the impact of mesenchymal stem cell (MSC)-derived exosomes (Exo) on cerebral ischemia and reperfusion (I/R) injury, along with the underlying mechanism. METHODS: An animal model of cerebral ischemia was induced using middle cerebral artery occlusion (MCAO), and a cell model utilizing Neuro-2a cells was established through oxygen-glucose deprivation/reoxygenation (OGD/R). Exosomes isolated from mouse MSCs were administered to mice or used to stimulate Neuro-2a cells...
February 10, 2024: Gene
https://read.qxmd.com/read/38339344/the-effect-of-non-overlapping-somatic-mutations-in-braf-nras-nf1-or-ckit-on-the-incidence-and-outcome-of-brain-metastases-during-immune-checkpoint-inhibitor-therapy-of-metastatic-melanoma
#31
JOURNAL ARTICLE
Wolfram Samlowski
Previous studies suggested that somatic BRAF and NRAS mutations in metastatic melanoma increase the risk for brain metastases. The risk related to other non-overlapping "driver" mutations is unknown. We performed a retrospective evaluation of the incidence, timing, and outcome of brain metastases in a population of melanoma patients that underwent uniform next-gen sequencing. All patients were treated with initial checkpoint inhibitor therapy. Seventeen of 88 patients (20.0%) developed brain metastases. Eleven patients had brain metastases at diagnosis (12...
January 30, 2024: Cancers
https://read.qxmd.com/read/38334825/vitamin-d-ameliorates-celecoxib-cardiotoxicity-in-a-doxorubicin-heart-failure-rat-model-via-enhancement-of-the-antioxidant-defense-and-minimizing-mitochondrial-dysfunction
#32
JOURNAL ARTICLE
Sepideh Azizian, Saleh Khezri, Mohammad Shabani, Saman Atashbar, Ahmad Salimi
Recent evidence suggests the mechanistic role of mitochondria and oxidative stress in the development of celecoxib-induced cardiotoxicity. On the other, it has reported the positive effects of vitamin D on oxidative stress and the maintenance of mitochondrial functions. This current study examined the cardiac effects of celecoxib, doxorubicin, vitamin D, and a combination of them in rats. The effect of 10 days of celecoxib (100 mg/kg/day), doxorubicin (2.5 mg/kg), vitamin D (60,000 U/kg), and their combination was studied on cardiac function according to serum lactate dehydrogenase (LDH), creatine kinase (CK), glutathione (GSH), and malondialdehyde (MDA) levels as well as mitochondrial succinate dehydrogenases (SDH) activity, reactive oxygen species (ROS) production, mitochondrial swelling, and mitochondrial membrane potential (MMP)...
February 9, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38322766/combinatorial-immune-checkpoint-blockade-increases-myocardial-expression-of-nlrp-3-and-secretion-of-h-fabp-nt-pro-bnp-interleukin-1%C3%AE-and-interleukin-6-biochemical-implications-in-cardio-immuno-oncology
#33
JOURNAL ARTICLE
V Quagliariello, M Passariello, I Bisceglia, A Paccone, A Inno, C Maurea, R Rapuano Lembo, L Manna, M Iovine, M L Canale, M Scherillo, P A Ascierto, D Gabrielli, C De Lorenzo, N Maurea
BACKGROUND: Immune checkpoint blockade in monotherapy or combinatorial regimens with chemotherapy or radiotherapy have become an integral part of oncology in recent years. Monoclonal antibodies against CTLA-4 or PD-1 or PDL-1 are the most studied ICIs in randomized clinical trials, however, more recently, an anti-LAG3 (Lymphocyte activation gene-3) antibody, Relatlimab, has been approved by FDA in combination with Nivolumab for metastatic melanoma therapy. Moreover, Atezolizumab is actually under study in association with Ipilimumab for therapy of metastatic lung cancer...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38320099/efficacy-and-safety-of-neoadjuvant-sintilimab-in-combination-with-flot-chemotherapy-in-patients-with-her2-negative-locally-advanced-gastric-or-gastroesophageal-junction-adenocarcinoma-an-investigator-initiated-single-arm-open-label-phase-ii-study
#34
JOURNAL ARTICLE
Ning Li, Zhi Li, Qiang Fu, Bin Zhang, Jian Zhang, Xiang-Bin Wan, Chao-Min Lu, Jin-Bang Wang, Wen-Ying Deng, Yi-Jie Ma, Liang-Yu Bie, Meng-Yu Wang, Jing Li, Qing-Xin Xia, Chen Wei, Su-Xia Luo
BACKGROUND: The addition of immune checkpoint inhibitors to neoadjuvant chemotherapy in operable advanced gastric or gastroesophageal junction (G/GEJ) cancer aroused wide interest. This study was designed to assess the efficacy and safety of neoadjuvant sintilimab, a programmed cell death protein-1 (PD-1) inhibitor, in combination with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy for HER2-negative locally advanced G/GEJ cancer. METHODS: Eligible patients with clinical stage cT4 and/or cN+M0 G/GEJ cancer were enrolled in this phase II study...
February 5, 2024: International Journal of Surgery
https://read.qxmd.com/read/38315872/management-of-acute-breakthrough-hemolysis-with-intensive-pegcetacoplan-dosing-in-patients-with-pnh
#35
JOURNAL ARTICLE
Morag Griffin, Richard J Kelly, Jens Peter Panse, Carlos DeCastro, Jeff Szer, Regina Horneff, Lisa Tan, Michael Yeh, Régis Peffault de Latour
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis leading to anemia, fatigue, and potentially life-threatening thrombotic complications. Breakthrough hemolysis (BTH) was first described in patients with PNH treated with terminal complement C5 inhibitors when intravascular hemolysis reoccurred despite treatment. Pegcetacoplan, the first proximal complement C3 inhibitor, offers broad hemolysis control in patients with PNH. While experience of managing BTH on C5 inhibitors is documented, very limited guidance exists for proximal complement inhibitors...
February 5, 2024: Blood Advances
https://read.qxmd.com/read/38311162/layered-double-hydroxides-ldhs-as-efficient-and-safe-carriers-for-mirna-inhibitors-in-vitro-and-in-vivo-assessment-of-biocompatibility
#36
JOURNAL ARTICLE
Mykaella Andrade de Araújo, Erivaldo Davi Dos Santos Júnior, Bruna Priscila Dos Santos, Ygor Daniel Ramos Dos Santos, Pedro Augusto Tibúrcio Paulino, Elane Conceição Dos Santos, Tayhana Priscila Medeiros Souza, Lucas Anhezini, Ênio José Bassi, Marcelo Duzzioni, Olagide Wagner de Castro, Tiago Gomes de Andrade, Camila Braga Dornelas, Daniel Leite Góes Gitaí
Layered double hydroxides (LDHs) have been employed as nano-sized carriers for therapeutic/bio-active molecules, including small interfering RNAs (siRNAs). However, the potential of LDHs nanoparticles for an efficient and safe antisense oligonucleotide (AMO) delivery still requires studies. In this research, we have tested the suitability of a Mg-Al-LDH-based nanocarrier loaded with a miRNA-196b-5p inhibitor. LDHs (and LDH-Oligo complex) were synthesized by the coprecipitation method followed by physicochemical characterization as hydrodynamic size, surface charge, crystallinity, and chemical groups...
March 1, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38308830/inhibition-of-choline-kinase-as-an-antiamoebic-approach-in-entamoeba-histolytica-infection
#37
JOURNAL ARTICLE
Z H Teh, B H Lim, W C See Too, L L Few
Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic colitis or amoebic liver abscess. Metronidazole has been the conventional treatment for intestinal amoebiasis, but concerns regarding resistance have emerged due to the identification of resistance pathways in E. histolytica. This study investigates a novel anti-amoebic approach targeting the CDP-choline pathway. Inhibition studies were conducted using potential choline kinase (CK) inhibitors to inhibit the EhCK enzyme, and RNA interference was employed to knock down the EhCK gene...
December 1, 2023: Tropical Biomedicine
https://read.qxmd.com/read/38308020/modified-r-bac-plus-btk-inhibitor-regimen-in-newly-diagnosed-young-patients-with-mantle-cell-lymphoma-a-real-world-retrospective-study
#38
JOURNAL ARTICLE
Wenqi Li, Yu Chang, Xiyang Liu, Ziqi Chen, Jinmiao Sun, Zurui Geng, Mingzhi Zhang, Lei Zhang
To explore the optimal treatment for young patients with untreated mantle cell lymphoma (MCL), we compared the efficacy and safety of R-CHOP/R-DHAP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone/rituximab, dexamethasone, cytarabine and cisplatin) and R-BAP (rituximab, bendamustine, cytarabine, and prednisone) plus BTK (Bruton's tyrosine kinase) inhibitors in newly diagnosed patients. Eighty-three young patients (≤ 65 years old) with newly diagnosed MCL admitted to the First Affiliated Hospital of Zhengzhou University from January 1, 2014, to June 1, 2023, using R-CHOP/R-DHAP or R-BAP plus BTK inhibitor were assessed in this study...
February 3, 2024: Annals of Hematology
https://read.qxmd.com/read/38304816/impact-of-inhibitor-loaded-with-pigments-content-on-properties-of-inorganic-zinc-rich-coatings
#39
JOURNAL ARTICLE
Shuangxi Zhou, Weijie Li, Jianxin Li, Ruguang Li
In order to overcome the poor dispersion of traditional inorganic zinc-rich coating, addressing the sedimentation and the agglomeration caused by high zinc powder content and improve the anti-corrosion performance of coatings. In this paper, the molybdate intercalated hydrotalcite flake zinc layer double hydroxide (ZnAl-NO3- /LDH) was synthesized by hydrothermal synthesis method at first, and the KH560 modified the Mo/LDH flake zinc powder was further obtained by ion exchange method. The results show that the samples have a layered structure of hydrotalcite with good crystal structure through X-ray diffraction (XRD) and Fourier transform infrared (FT-IR), and the molybdate corrosion inhibiting ions inserted successfully into the interlayer structure of hydrotalcite...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38301909/nr4a1-depletion-inhibits-colorectal-cancer-progression-by-promoting-necroptosis-via-the-rig-i-like-receptor-pathway
#40
JOURNAL ARTICLE
Jinghan Zhu, Juntao Li, Kexi Yang, Yuqi Chen, Jiayu Wang, Yuxin He, Kanger Shen, Kun Wang, Tongguo Shi, Weichang Chen
Necroptosis is a regulated necrotic cell death mechanism and plays a crucial role in the progression of cancers. However, the potential role and mechanism of necroptosis in colorectal cancer (CRC) has not been fully elucidated. In this study, we found that nuclear receptor subfamily 4 group A member 1 (NR4A1) was highly expressed in CRC cells treated with TNF-α, Smac mimetic, and z-VAD-FMK (TSZ). The depletion of NR4A1 significantly enhanced the sensitivity of CRC cells to TSZ-induced necroptosis, while NR4A1 overexpression suppressed these effects, as evidenced by the LDH assay, flow cytometry analysis of cell death, PI staining, and expression analysis of necrosome complexes (RIPK1, RIPK3, and MLKL)...
January 30, 2024: Cancer Letters
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