keyword
https://read.qxmd.com/read/38536584/complications-of-outpatient-chest-tube-management-for-prolonged-air-leaks-after-pulmonary-surgery
#1
JOURNAL ARTICLE
Ryan J Randle, Prasha Bhandari, Hao He, Mark F Berry, Leah M Backhus, Natalie S Lui, Douglas Z Liou, Joseph B Shrager
PURPOSE: Air leaks are common after pulmonary surgery. Prolonged air leaks (PALs) may persist through discharge and often are managed with one-way valve devices (OWD). We sought to determine the course and complications of patients discharged with OWDs, risk factors for complications, and to evaluate the utility of clamp trials before chest tube (CT) removal. METHODS: Single-institution, retrospective review of patients discharged with a OWD after pulmonary surgery between 2008 and 2022...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38507736/multiomic-profiling-of-human-clonal-hematopoiesis-reveals-genotype-and-cell-specific-inflammatory-pathway-activation
#2
JOURNAL ARTICLE
Jonathan Brett Heimlich, Pawan Bhat, Alyssa Parker, Matthew T Jenkins, Caitlyn Vlasschaert, Jessica Ulloa, Joseph Van Amburg, Chad R Potts, Sydney Olson, Alexander J Silver, Ayesha Ahmad, Brian Sharber, Donovan Brown, Ningning Hu, Peter van Galen, Michael R Savona, Alexander G Bick, Paul Brent Ferrell
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk through inflammation in the peripheral blood1. Here, we profile peripheral blood gene expression in 66,968 single cells from a cohort of 17 CH patients and 7 controls. Using a novel mitochondrial DNA barcoding approach, we were able to identify and separately compare mutant TET2 and DNMT3A cells to non-mutant counterparts. We discovered the vast majority of mutated cells were in the myeloid compartment...
March 20, 2024: Blood Advances
https://read.qxmd.com/read/38391131/-challenges-in-teaching-first-aids-at-schools-analysis-of-spanish-educational-legislation-lomloe-and-curricular-guidance
#3
JOURNAL ARTICLE
Roberto Barcala-Furelos, Lucía Peixoto-Pino, Julio Zanfaño-Ongil, Santiago Martínez-Isasi
OBJECTIVE: Teaching first aid (FA) to children and young people is a priority strategy in Public Health. The aim of this paper was to review and analyze new educational legislation within the FA curriculum framework, which is necessary for providing teachers and healthcare professionals with a practical guide that guides teaching to train first responders in different school stages. METHODS: A group of four experts with curricular experience at different educational levels, as well as in the field of FA, participated in this analysis...
February 23, 2024: Revista Española de Salud Pública
https://read.qxmd.com/read/38304664/assessment-of-knowledge-attitude-and-practice-of-first-aid-management-of-choking-among-primary-school-teachers-in-riyadh-saudi-arabia-a-cross-sectional-study
#4
JOURNAL ARTICLE
Mazyad M Alenezi, Zinab H Bohulaigah, Nader F Aldajani, Lamya G Alotaibi, Mthayel F Alshammari
BACKGROUND: Understanding first aid is crucial for immediate intervention during health emergencies, with choking representing a significant danger, particularly for young children. Obstructed airways commonly lead to choking incidents, carrying substantial risks if not swiftly dealt with. This research endeavors to evaluate the comprehension, perspectives, and implementation of first aid measures for choking incidents among primary school teachers in Riyadh, Saudi Arabia, an area of paramount importance with minimal existing research within this particular demographic...
January 2024: Curēus
https://read.qxmd.com/read/38178616/kinetics-of-neutrophil-extracellular-traps-and-cytokines-in-oral-mucositis-and-candida-infection
#5
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Sicília Rezende Oliveira, Fernanda Vieira Heimlich, Bárbara Maria de Amorim-Santos, Ayda Henriques Schneider, Ana Carolina Velasco Pondé de Sena, Karla Emília de Sá Rodrigues, Soraia Macari, Daniele Glória Souza, Denise Vieira Travassos, Lucas Guimarães Abreu, Tarcília Aparecida Silva, Ricardo Alves Mesquita
OBJECTIVE: This study investigated the concentrations of neutrophil extracellular traps (NET) and salivary cytokines (IL-1β, IL-6, IL-8/CXCL8, TNF, and TGF-β1) in patients undergoing chemotherapy and their associations with oral mucositis (OM) and Candida infection. MATERIALS AND METHODS: This prospective longitudinal study performed at a Brazilian service included 60 adults diagnosed with hematolymphoid diseases. Saliva samples were collected on days D0, D3, D10, and D15...
January 4, 2024: Oral Diseases
https://read.qxmd.com/read/38154442/influence-of-anxiety-depression-on-chemotherapy-induced-oral-mucositis-and-related-quality-of-life-a-prospective-cohort-study
#6
JOURNAL ARTICLE
José Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Sicília Rezende Oliveira, Victor Zanetti Drumond, Denise Vieira Travassos, Lucas Guimarães Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcília Aparecida Silva
OBJECTIVE: The impact of anxiety and depression on chemotherapy-induced oral mucositis has not been extensively explored in the literature. The aim of the present study was to evaluate anxiety/depressive symptoms, health-related quality of life, and oral health-related quality of life and their association with oral mucositis among individuals receiving chemotherapy. METHODS: This is a prospective longitudinal study carried out at a Brazilian referral service. The Hospital Anxiety and Depression Scale (HADS), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Oral Health Impact Profile questionnaire (OHIP-14) were applied at D0 (before chemotherapy) and D15 of chemotherapy...
December 24, 2023: Journal of Psychosomatic Research
https://read.qxmd.com/read/38050299/the-heimlich-maneuver-and-chest-compression-relieve-mask-ventilation-difficulties-caused-by-asymptomatic-laryngeal-mass-a-case-report-and-review-of-literature
#7
JOURNAL ARTICLE
Xuefei Zhou, Longfei Wang, Yonghua Zhang, Qiuyue Wu, Yunfei Cao
RATIONALE: Some laryngeal masses are typically asymptomatic and easily ignored. However, they can be rare causes of unanticipated difficult airway, leading to critical situations such as "cannot ventilate" or "cannot ventilate and cannot intubate" during anesthesia induction. Inappropriate airway management in such scenarios can have catastrophic consequences for an anesthetized patient. Here we report a case of sudden, unanticipated difficult mask ventilation caused by an asymptomatic supraglottic mass during sedative induction, which was quickly and effectively relieved by the Heimlich maneuver and chest compression...
December 1, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37986782/cost-effective-and-scalable-clonal-hematopoiesis-assay-provides-insight-into-clonal-dynamics
#8
Taralynn Mack, Caitlyn Vlasschaert, Kelly von Beck, Alexander J Silver, J Brett Heimlich, Hannah Poisner, Henry Robert Condon, Jessica Ulloa, Andrew L Sochacki, Travis P Spaulding, Ashwin Kishtagari, Cosmin A Bejan, Yaomin Xu, Michael R Savona, Angela Jones, Alexander Bick
Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related phenomenon that occurs when hematopoietic stem cells acquire mutations in a select set of genes commonly mutated in myeloid neoplasia which then expand clonally. Current sequencing assays to detect CHIP are not optimized for the detection of these variants and can be cost-prohibitive when applied to large cohorts or serial sequencing. Here, we present and validate a CHIP targeted sequencing assay that is affordable (∼$8/sample), accurate and highly scalable...
November 9, 2023: medRxiv
https://read.qxmd.com/read/37889325/proposal-of-a-prophylactic-photobiomodulation-protocol-for-chemotherapy-induced-oral-and-oropharyngeal-mucositis-a-randomized-clinical-trial
#9
JOURNAL ARTICLE
Fernanda Vieira Heimlich, José Alcides Almeida de Arruda, Nickolas Mendes Pereira, Larissa Dos Santos Faria, Lucas Guimarães Abreu, Marcus Vinícius Lucas Ferreira, Fabiana Maria Kakehasi, Denise Vieira Travassos, Tarcília Aparecida Silva, Ricardo Alves Mesquita
Photobiomodulation therapy (PBMT) is widely used in oncology settings, but lack of assessment standardization is the main barrier to optimization of clinical protocols. This study analyzed three PBMT protocols for preventing oral and oropharyngeal mucositis (OM) in patients undergoing chemotherapy (CT) and/or hematopoietic stem cell transplantation (HSCT). This is a preliminary randomized blind clinical trial. Group 1 received intraoral prophylactic PBMT, Group 2 received intraoral and oropharyngeal PBMT, and Group 3 received intraoral, oropharyngeal, and extraoral PBMT...
October 27, 2023: Lasers in Medical Science
https://read.qxmd.com/read/37695097/esophageal-rupture-after-heimlich-maneuver-a-case-report-and-literature-review
#10
JOURNAL ARTICLE
Antonio Basile, Rocco Spagnuolo, Vincenzo Cosco, Stefano Rodinò, Francesco Luzza, Ludovico Abenavoli
The Heimlich maneuver (HM) is lifesaving in a patient choked by a foreign body. It is safe and effective and does not require specific instruments. Nevertheless, rare severe complications have been reported, such as traumatic injury of the gastrointestinal tract, pneumomediastinum, rib fracture, diaphragm rupture, acute thrombosis of abdominal aortic aneurysm and mesenteric laceration. Abdominal injuries are the most common complications, especially esophageal and gastric wall rupture. This anatomic site is the most common location of organ injuries, in consequence of the main target of the force generated by the HM...
September 11, 2023: Minerva gastroenterology
https://read.qxmd.com/read/37539077/blockade-of-il-6-signaling-alleviates-atherosclerosis-in-tet2-deficient-clonal-hematopoiesis
#11
JOURNAL ARTICLE
Wenli Liu, Mustafa Yalcinkaya, Inés Fernández Maestre, Malgorzata Olszewska, Patrick B Ampomah, J Brett Heimlich, Ranran Wang, Pablo Sánchez Vela, Tong Xiao, Alexander G Bick, Ross Levine, Eirini P Papapetrou, Peter Libby, Ira Tabas, Nan Wang, Alan R Tall
Clonal hematopoiesis (CH) increases the risk of atherosclerotic cardiovascular disease possibly due to increased plaque inflammation. Human studies suggest that limitation of interleukin-6 (IL-6) signaling could be beneficial in people with large CH clones, particularly in TET2 CH. Here we show that IL-6 receptor antibody treatment reverses the atherosclerosis promoted by Tet2 CH, with reduction of monocytosis, lesional macrophage burden and macrophage colony-stimulating factor 1 receptor (CSF1R) expression...
June 2023: Nat Cardiovasc Res
https://read.qxmd.com/read/37498674/genetic-modification-of-inflammation-and-clonal-hematopoiesis-associated-cardiovascular-risk
#12
JOURNAL ARTICLE
Zhi Yu, Trevor P Filder, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin, Taralynn Mack, Abhishek Niroula, J Brett Heimlich, Seyedeh M Zekavat, Christopher J Gibson, Gabriel K Griffin, Yuxuan Wang, Gina M Peloso, Nancy Heard-Costa, Daniel Levy, Ramachandran S Vasan, François Aguet, Kristin G Ardlie, Kent D Taylor, Stephen S Rich, Jerome I Rotter, Peter Libby, Siddhartha Jaiswal, Benjamin L Ebert, Alexander G Bick, Alan R Tall, Pradeep Natarajan
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVD), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. CHIP was identified using whole exome sequencing data of blood DNA and modeled both as a composite and for common drivers (DNMT3A, TET2, ASXL1, and JAK2) separately. We developed predicted gene expression scores for 26 inflammasome-related genes and assessed how they modify CHIP-associated CVD risk...
July 27, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37059445/a-pilot-study-of-preparedness-of-dentists-in-the-united-arab-emirates-to-deal-with-medical-emergencies
#13
JOURNAL ARTICLE
Helmi Shaath, Basheer Salman, Dalia Daghistani, Rayan Koutaich, Alya Alhammadi, Nermeen Yakoub, Manal A Awad
OBJECTIVES:  The purpose of this pilot study is to assess the United Arab Emirates dentists' preparedness to manage medical emergencies. MATERIALS AND METHODS:  Ninety-seven licensed dentists participated in this study. Dentists responded to self-administrated questionnaires that contained 23 questions divided into five parts. The first part collected data on participants' sex, years of experience, and whether they are general dental practitioner (GDP) or specialists...
April 14, 2023: European Journal of Dentistry
https://read.qxmd.com/read/37042758/genome-sequence-and-assembly-of-18-fusarium-isolates-from-florida-citrus-under-high-huanglongbing-disease-pressure-and-california-citrus-under-low-huanglongbing-disease-pressure
#14
JOURNAL ARTICLE
Tania Kurbessoian, Gretchen Heimlich-Villalta, Nichole Ginnan, Flavia Campos Vieira, Philippe E Rolshausen, M Caroline Roper, Jason E Stajich
The genomes of eighteen Fusarium isolates cultured from diseased and healthy citrus trees were sequenced, assembled, and annotated. Isolate species identification was confirmed using single marker (TEF1-alpha) phylogenetic assessment. Studies of the traits and genotypes of plant-associated isolates are important to understanding the fungal contribution to phytobiomes of citrus.
April 12, 2023: Microbiology Resource Announcements
https://read.qxmd.com/read/36792922/redifferentiation-of-differentiated-thyroid-cancer-clinical-insights-from-a-narrative-review-of-literature
#15
REVIEW
Douglas Van Nostrand, Irina Veytsman, Kanchan Kulkarni, Layla Heimlich, Kenneth D Burman
Background: Patients who have metastatic differentiated thyroid cancer (mDTC) frequently have negative diagnostic and/or post-therapy radioiodine scans. As a result, 131 I therapy is frequently no longer considered a therapeutic option for these patients. However, with the knowledge of genomic alterations of patients with mDTC, the use of selected agents in specific patient groups may be used with the intention to re-establish 131 I uptake (i.e., redifferentiation ) and additional 131 I therapy. The objectives of this narrative review are to present definitions of related terminology, a brief overview of the molecular mechanisms of redifferentiating agents, and a narrative review of the literature for redifferentiation in patients who have radioiodine refractory mDTC...
June 2023: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/36728635/exploring-the-use-of-common-strict-search-criteria-in-nursing-literature-searches
#16
JOURNAL ARTICLE
Eleanor Shanklin Truex, Emily Spinner, Jean Hillyer, A'Llyn Ettien, Sarah Wade, Courtney Calhoun, Grace Wolf, Rebecca Hedreen, Layla Heimlich, Annie Nickum, Susan C Vonderheid
BACKGROUND: Health sciences librarians and nursing journal contributors have expressed concern about the impact of using strict parameters when searching the literature. PURPOSE: The purpose of this study was to explore the use of strict search criteria (eg, 5-year rule, "nurse as author") by direct care nurses and nursing students. METHODS: Fourteen online focus groups were conducted with 54 participants: direct care nurses, health sciences librarians, nursing faculty, and nursing students...
December 30, 2022: Nurse Educator
https://read.qxmd.com/read/36652671/a-practical-approach-to-curate-clonal-hematopoiesis-of-indeterminate-potential-in-human-genetic-datasets
#17
JOURNAL ARTICLE
Caitlyn Vlasschaert, Taralynn Mack, Jonathan Brett Heimlich, Abhishek Niroula, Md Mesbah Uddin, Joshua S Weinstock, Brian Sharber, Alexander J Silver, Yaomin Xu, Michael R Savona, Christopher J Gibson, Matthew B Lanktree, Michael J Rauh, Benjamin L Ebert, Pradeep Natarajan, Siddhartha Jaiswal, Alexander G Bick
Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples sequenced using approaches that cover the whole genome, whole exome or targeted genetic regions; however, differentiating true CHIP mutations from sequencing artifacts and germline variants is a considerable bioinformatic challenge. We present a stepwise method that combines filtering based on sequencing metrics, variant annotation, and population-based associations to increase the accuracy of CHIP calls...
January 18, 2023: Blood
https://read.qxmd.com/read/35993910/association-of-anxiety-and-depression-with-oral-mucositis-a-systematic-review
#18
REVIEW
José Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimarães Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcília Aparecida Silva
OBJECTIVE: Anxiety and depression are frequent conditions among individuals undergoing antineoplastic therapy, but their relationship with oral mucositis is unclear. This systematic review evaluated the potential association of anxiety and depression with frequency and severity of chemo/radiotherapy-induced oral mucositis. MATERIALS AND METHODS: Electronic searches were undertaken in five databases supplemented by manual scrutiny and gray literature searches in three other databases...
August 22, 2022: Oral Diseases
https://read.qxmd.com/read/35698284/complications-of-endobronchial-valve-placement-for-bronchoscopic-lung-volume-reduction-insights-from-the-food-and-drug-administration-manufacturer-and-user-facility-device-experience-maude
#19
JOURNAL ARTICLE
See-Wei Low, Karen L Swanson, Justin Z Lee, Min-Choon Tan, Rodrigo Cartin-Ceba, Kenneth K Sakata, Fabien Maldonado
BACKGROUND: Patients with advanced emphysema experience breathlessness due to impaired respiratory mechanics and diaphragm dysfunction. Bronchoscopic lung volume reduction (BLVR) is a minimally invasive bronchoscopic procedure done to reduce hyperinflation and air trapping, promoting atelectasis in the targeted lobe and allowing improved respiratory mechanics. Real-world data on safety and complications outside of clinical trials of BLVR are limited. METHODS: We queried the US Food and Drug Administrations (FDA) Manufacturers and User Device Experience database from May 2019 to June 2020 for reports involving BLVR with endobronchial valve (EBV) placement...
July 1, 2022: Journal of Bronchology & Interventional Pulmonology
https://read.qxmd.com/read/35646206/blunt-myocardial-injury-and-gastrointestinal-hemorrhage-following-heimlich-maneuver-a-case-report-and-literature-review
#20
JOURNAL ARTICLE
Chu Wang, Zhen-Zhou Wang, Tian-Bing Wang
No abstract text is available yet for this article.
2022: World Journal of Emergency Medicine
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