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Roxann Diez Gross, Ronit Gisser, Gregory Cherpes, Katie Hartman, Rishi Maheshwary
Prader-Willi Syndrome (PWS) is caused by a genetic imprinting abnormality resulting from the lack of expression of the paternal genes at 15q11-q13. Intellectual disability, low muscle tone, and life-threatening hyperphagia are hallmarks of the phenotype. The need for the Heimlich maneuver, death from choking, and pulmonary infection occur in a disproportionally high number of persons with PWS. The widely held belief is that eating behaviors are responsible for choking and aspiration; yet, no investigation had sought to determine if swallowing impairments were present in persons with PWS...
October 19, 2016: American Journal of Medical Genetics. Part A
D A Rund
Choking results in many deaths each year. Yet a simple procedure that can be performed by almost anyone, even the victims, could prevent this from happening.
December 1989: Physician and Sportsmedicine
Christopher C Stanley, Kate D Westmoreland, Brett J Heimlich, Nader K El-Mallawany, Peter Wasswa, Idah Mtete, Mercy Butia, Salama Itimu, Mary Chasela, Mary Mtunda, Mary Chikasema, Victor Makwakwa, Bongani Kaimila, Edwards Kasonkanji, Fred Chimzimu, Coxcilly Kampani, Bal M Dhungel, Robert Krysiak, Nathan D Montgomery, Yuri Fedoriw, Nora E Rosenberg, N George Liomba, Satish Gopal
Burkitt lymphoma (BL) is the most common paediatric cancer in sub-Saharan Africa (SSA). Anthracyline-based treatment is standard in resource-rich settings, but has not been described in SSA. Children ≤18 years of age with newly diagnosed BL were prospectively enrolled from June 2013 to May 2015 in Malawi. Staging and supportive care were standardized, as was treatment with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. Among 73 children with BL, median age was 9·2 years (interquartile range 7·7-11·8), 48 (66%) were male and two were positive for human immunodeficiency virus...
June 2016: British Journal of Haematology
Anne Schneibel, Marion Stellmes, Achim Röder, Manfred Finckh, Rasmus Revermann, David Frantz, Joachim Hill
The repopulation of abandoned areas in Angola after 27years of civil war led to a fast and extensive expansion of agricultural fields to meet the rising food demand. Yet, the increase in crop production at the expense of natural resources carries an inherent potential for conflicts since the demand for timber and wood extraction are also supposed to rise. We use the concept of ecosystem services to evaluate the trade-off between food and woody biomass. Our study area is located in central Angola, in the highlands of the upper Okavango catchment...
April 1, 2016: Science of the Total Environment
Matteo Bruschettini, Olga Romantsik, Luca Antonio Ramenghi, Simona Zappettini, Colm P F O'Donnell, Maria Grazia Calevo
BACKGROUND: Pneumothorax occurs more frequently in the neonatal period than at any other time of life and is associated with increased mortality and morbidity. It may be treated with either needle aspiration or insertion of a chest tube. The former consists of aspiration of air with a syringe through a needle or an angiocatheter, usually through the second or third intercostal space in the midclavicular line. The chest tube is usually placed in the anterior pleural space passing through the sixth intercostal space into the pleural opening, turned anteriorly and directed to the location of the pneumothorax, and then connected to a Heimlich valve or an underwater seal with continuous suction...
2016: Cochrane Database of Systematic Reviews
Perzila Ara, Shaokoon Cheng, Michael Heimlich, Eryk Dutkiewicz
Recent developments in capsule endoscopy have highlighted the need for accurate techniques to estimate the location of a capsule endoscope. A highly accurate location estimation of a capsule endoscope in the gastrointestinal (GI) tract in the range of several millimeters is a challenging task. This is mainly because the radio-frequency signals encounter high loss and a highly dynamic channel propagation environment. Therefore, an accurate path-loss model is required for the development of accurate localization algorithms...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Alistair Harrison, Laura G Dubois, Lisa St John-Williams, M Arthur Moseley, Rachael L Hardison, Derek R Heimlich, Alexander Stoddard, Joseph E Kerschner, Sheryl S Justice, J Will Thompson, Kevin M Mason
A thorough understanding of the molecular details of the interactions between bacteria and host are critical to ultimately prevent disease. Recent technological advances allow simultaneous analysis of host and bacterial protein and metabolic profiles from a single small tissue sample to provide insight into pathogenesis. We used the chinchilla model of human otitis media to determine, for the first time, the most expansive delineation of global changes in protein and metabolite profiles during an experimentally induced disease...
March 2016: Molecular & Cellular Proteomics: MCP
Samuel S Kim, Zain Khalpey, Sherry L Daugherty, Mohammad Torabi, Alex G Little
BACKGROUND: This study determined patterns of chest tube (CT) selection and management after open lobectomy and minimally invasive lobectomy by thoracic surgeons. METHODS: Surveys were sent electronically to 5,175 thoracic surgeons, and 475 were completed. Responses, blinded so individuals could not be identified, were analyzed and compared according to surgeon characteristics (academic/private practice, years in practice, lobectomy volume, and geographic region)...
March 2016: Annals of Thoracic Surgery
J Brett Heimlich, Joshua S Speed, Paul M O'Connor, Jennifer S Pollock, Tim M Townes, Steffen E Meiler, Abdullah Kutlar, David M Pollock
BACKGROUND AND PURPOSE: Endothelin-1 (ET-1) is increased in patients with sickle cell disease and may contribute to the development of sickle cell nephropathy. The current study was designed to determine whether ET-1 acting via the ETA receptor contributes to renal injury in a mouse model of sickle cell disease. EXPERIMENTAL APPROACH: Adult, humanized HbSS (homozygous for sickle Hb) mice had increased ET-1 mRNA expression in both the cortex and the glomeruli compared with mice heterozygous for sickle and Hb A (HbAS controls)...
January 2016: British Journal of Pharmacology
J V Pai-Dhungat, Falguni Parikh
No abstract text is available yet for this article.
March 2015: Journal of the Association of Physicians of India
Joshua S Broder, James W Fox, Judy Milne, Brent Jason Theiling, Ann White
Medical errors are commonly multifactorial, with adverse clinical consequences often requiring the simultaneous failure of a series of protective layers, termed the Swiss Cheese model. Remedying and preventing future medical errors requires a series of steps, including detection, mitigation of patient harm, disclosure, reporting, root cause analysis, system modification, regulatory action, and engineering and manufacturing reforms. We describe this process applied to two cases of improper orientation of a Heimlich valve in a thoracostomy tube system, resulting in enlargement of an existing pneumothorax and the development of radiographic features of tension pneumothorax...
April 2016: Emergency Medicine Journal: EMJ
Joshua S Speed, J Brett Heimlich, Kelly A Hyndman, Brandon M Fox, Vivek Patel, Masashi Yanagisawa, Jennifer S Pollock, Jens M Titze, David M Pollock
The current study was designed to determine whether vascular endothelial-derived endothelin-1 (ET-1) is important for skin Na(+) buffering. In control mice (C57BL/6J), plasma Na(+) and osmolarity were significantly elevated in animals on high- vs. low-salt (HS and LS, respectively) intake. The increased plasma Na(+) and osmolarity were associated with increased ET-1 mRNA in vascular tissue. There was no detectable difference in skin Na(+):H2O in HS fed mice (0.119 ± 0.005 mM vs. 0.127 ± 0.007 mM; LS vs. HS); however, skin Na(+):H2O was significantly increased by blockade of the endothelin type A receptor with ABT-627 (0...
December 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
A N Tavare, D D Creer, S Khan, R Vancheeswaran, S S Hare
A prospective study of 489 consecutive outpatient image-guided percutaneous lung biopsies was conducted to determine whether early discharge, incorporating ambulatory Heimlich valve drain, is potentially advantageous to the National Health Service. Patients were discharged at 30 or 60 min, with significant pneumothoraces treated using Heimlich valve. 485 (99.2%) patients were successfully discharged early, 402 at 30 min. 87 (17.8%) patients developed pneumothorax: 52 required Heimlich valve; 5 proceeded to biopsy with Heimlich valve in situ...
February 2016: Thorax
Oliver J Bintcliffe, Rob J Hallifax, Anthony Edey, David Feller-Kopman, Y C Gary Lee, Charles H Marquette, Jean-Marie Tschopp, Douglas West, Najib M Rahman, Nick A Maskell
There are substantial differences in international guidelines for the management of pneumothorax and much geographical variation in clinical practice. These discrepancies have, in part, been driven by a paucity of high-quality evidence. Advances in diagnostic techniques have increasingly allowed the identification of lung abnormalities in patients previously labelled as having primary spontaneous pneumothorax, a group in whom recommended management differs from those with clinically apparent lung disease. Pathophysiological mechanisms underlying pneumothorax are now better understood and this may have implications for clinical management...
July 2015: Lancet Respiratory Medicine
Marie Godet, Jérôme Chevillotte
No abstract text is available yet for this article.
May 2015: Revue de L'infirmière
Basheer Tashtoush, Jonathan Schroeder, Roya Memarpour, Eduardo Oliveira, Michael Medina, Anas Hadeh, Jose Ramirez, Laurence Smolley
The hemodynamic compromise caused by a large aspirated food particle in the airway can become the focus of medical attention and a distraction from rare but fatal Heimlich maneuver related injuries after an incident of food aspiration. We herein present a case of an 84-year-old man who was brought to the emergency department after an episode of choking at a restaurant followed by several failed Heimlich maneuver attempts. Despite relieving the airway obstruction by extracting a large piece of steak from the airway, the patient remained hypotensive and required continued hemodynamic support...
2015: Case Reports in Emergency Medicine
Derek R Heimlich, Alistair Harrison, Kevin M Mason
Innate immune responses function as a first line of host defense against the development of bacterial infection, and in some cases to preserve the sterility of privileged sites in the human host. Bacteria that enter these sites must counter host responses for colonization. From the host's perspective, the innate immune system works expeditiously to minimize the bacterial threat before colonization and subsequent dysbiosis. The multifactorial nature of disease further challenges predictions of how each independent variable influences bacterial pathogenesis...
December 1, 2014: Antibiotics
Pierre Barbier de Reuille, Anne-Lise Routier-Kierzkowska, Daniel Kierzkowski, George W Bassel, Thierry Schüpbach, Gerardo Tauriello, Namrata Bajpai, Sören Strauss, Alain Weber, Annamaria Kiss, Agata Burian, Hugo Hofhuis, Aleksandra Sapala, Marcin Lipowczan, Maria B Heimlicher, Sarah Robinson, Emmanuelle M Bayer, Konrad Basler, Petros Koumoutsakos, Adrienne H K Roeder, Tinri Aegerter-Wilmsen, Naomi Nakayama, Miltos Tsiantis, Angela Hay, Dorota Kwiatkowska, Ioannis Xenarios, Cris Kuhlemeier, Richard S Smith
Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation and gene expression must be quantified. This quantification is usually performed either in full 3D, which is computationally expensive and technically challenging, or on 2D planar projections, which introduces geometrical artifacts on highly curved organs. Here we present MorphoGraphX (, a software that bridges this gap by working directly with curved surface images extracted from 3D data...
2015: ELife
Sohan Lal Solanki, Shivendu Bansal, Arvind Khare, Amit Jain
Aspiration of foreign bodies (FBs) by children can lead to serious illness and sometimes even death. Bronchoscopic removal of the FB is necessary to prevent from any catastrophic event. Sometimes bronchoscopic removal is not possible due to the larger size of the FB, sharp FB, or long duration FB. Tracheostomy is normally used for the removal of such FBs. The aim of this case report is to highlight the use of Heimlich maneuver for the removal of such FBs before opting invasive procedures. In the present case, a 5-year-old child was presented with history of FB aspiration 5 h back...
July 2011: Anesthesia, Essays and Researches
Apostolos Gogakos, Nikolaos Barbetakis, George Lazaridis, Antonis Papaiwannou, Anastasia Karavergou, Sofia Lampaki, Sofia Baka, Ioannis Mpoukovinas, Vasilis Karavasilis, Ioannis Kioumis, Georgia Pitsiou, Nikolaos Katsikogiannis, Kosmas Tsakiridis, Aggeliki Rapti, Georgia Trakada, Athanasios Zissimopoulos, Katerina Tsirgogianni, Konstantinos Zarogoulidis, Paul Zarogoulidis
The Heimlich valve is a small one-way valve used for chest drainage that empties into a flexible collection device and prevents return of gases or fluids into the pleural space. The Heimlich valve is less than 13 cm (5 inches) long and facilitates patient ambulation. Currently there are several systems in the market. It can be used in many patients instead of a traditional water seal drainage system. The Heimlich chest drainage valve was developed so that the process of draining the pleural cavity could be accomplished in a safe, relatively simple, and efficient manner...
March 2015: Annals of Translational Medicine
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