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JOURNAL ARTICLE
Lauren Gyemi, Asher Selznick, Brad Petrisor, Michelle Ghert
PURPOSE: The primary objective of this study was to determine time to full weight-bearing after the use of a calcium-sulfate-calcium phosphate bone substitute (CaSO4/CaPO4) as a bone void filler in the treatment of primary benign bone tumours following intralesional curettage. The secondary objectives were to determine surgical complications and recurrence rates. METHODS: Retrospective review of patients identified from a surgeon-specific orthopaedic oncology database, who underwent curettage of benign bone tumours and subsequent bone void filling with CaSO4/CaPO4...
2024: Journal of Orthopaedic Surgery
#2
COMPARATIVE STUDY
Riccardo Mastroianni, Giuseppe Chiacchio, Leonard Perpepaj, Gabriele Tuderti, Aldo Brassetti, Umberto Anceschi, Mariaconsiglia Ferriero, Leonardo Misuraca, Simone D'Annunzio, Alfredo Maria Bove, Salvatore Guaglianone, Rocco Simone Flammia, Flavia Proietti, Marco Pula, Giulio Milanese, Costantino Leonardo, Andrea Benedetto Galosi, Giuseppe Simone
Off-clamp partial nephrectomy represents one of the latest developments in nephron-sparing surgery, with the goal of preserving renal function and reducing ischemia time. The aim of this study was to evaluate and compare the functional, oncologic, and perioperative outcomes between off-clamp robot-assisted partial nephrectomy (off-C RAPN) and off-clamp open partial nephrectomy (off-C OPN) through a propensity score-matched (PSM) analysis. A 1:1 PSM analysis was used to balance variables potentially affecting postoperative outcomes...
April 28, 2024: Sensors
#3
REVIEW
Akash A Shah, Joseph H Schwab
Spinal metastasis is exceedingly common in patients with cancer and its prevalence is expected to increase. Surgical management of symptomatic spinal metastasis is indicated for pain relief, preservation or restoration of neurologic function, and mechanical stability. The overall prognosis is a major driver of treatment decisions; however, clinicians' ability to accurately predict survival is limited. In this narrative review, we first discuss the NOMS decision framework used to guide decision making in the treatment of patients with spinal metastasis...
May 5, 2024: Diagnostics
#4
Andrea Angelini, Alberto D'Amico, Stefania Paolilli, Riccardo Signori, Giovanni Baldin, Giuseppe Di Rubbo, Luca Denaro, Pietro Ruggieri
Metastases are complications of primary tumors due to prolonged cancer survival and have become an important issue for oncological patients and the most frequent cause of death and disability. Bone metastases occur at a later stage of cancer disease, and the spine is the most frequent site. To date, the aim of the treatment of metastases remains to be the control of disease and provide a satisfactory quality of life. The decision making of treatment is influenced by several factors such as the status of the primary disease, the number of metastases, site involvement, and the performance status of the patients...
April 30, 2024: Diagnostics
#5
REVIEW
Armond J Isaak, GeGe R Clements, Rand Gabriel M Buenaventura, Glenn Merlino, Yanlin Yu
Melanoma is the most severe and fatal form of skin cancer, resulting from multiple gene mutations with high intra-tumor and inter-tumor molecular heterogeneity. Treatment options for patients whose disease has progressed beyond the ability for surgical resection rely on currently accepted standard therapies, notably immune checkpoint inhibitors and targeted therapies. Acquired resistance to these therapies and treatment-associated toxicity necessitate exploring novel strategies, especially those that can be personalized for specific patients and/or populations...
May 4, 2024: International Journal of Molecular Sciences
#6
REVIEW
Elena Azzini, Tiziano Furini, Angela Polito, Luca Scalfi, Alessandro Pinto, Valeria Gasperi, Isabella Savini, On Behalf Of The Sinu Nutrition In Oncology Working Group
Due to the high mortality rate in Western countries, pancreatic cancer is considered one of the big killers , leaving patients and their families with little hope upon diagnosis. Although surgical and drug therapies are critical for cancer patients to improve life expectancy and alleviation of suffering, nutrition plays a key role in improving cancer treatment outcomes. This narrative review, conducted as part of the activities of the Italian Society of Human Nutrition (SINU) working group in oncology, focuses on the prevalence of vitamin malnutrition among pancreatic cancer patients...
April 27, 2024: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Vittorio Ramella, Andrea Ferrari, Federico Cesare Novati, Zoran Marij Arnež, Grace Marchi, Agostino Rodda, Stefano Bottosso, Giovanni Papa
Background : Cervical esophageal reconstruction is vital to improve the quality of life in cancer surgery patients. Microsurgery is crucial in providing vascularized tissue for defect repair, particularly in secondary cases with a higher risk of failure due to larger defects and damage from previous surgery and radiotherapy. The purpose of this study was to describe the clinical characteristics of a series of patients who underwent secondary repair of esophageal defects and provide practical information for the management and treatment of such cases based on the authors' experience and the literature review...
May 6, 2024: Journal of Clinical Medicine
#8
REVIEW
Arthi Sridhar, Hina Khan, Binoy Yohannan, Kok Hoe Chan, Nilansh Kataria, Syed Hasan Jafri
The therapeutic landscape of the management of stage III non-small cell lung cancer (NSCLC) has drastically evolved with the incorporation of immunotherapy and targeted therapy. Stage III NSCLC accounts for one-third of the cases and the treatment strategy of these locally advanced presentations are diverse, ranging from surgical to non-surgical options; with the incorporation of chemo-immunotherapy, radiation, and targeted therapies wherever applicable. The staging of this disease has also changed, and it is essential to have a strong multidisciplinary approach to do justice to patient care...
April 30, 2024: Journal of Clinical Medicine
#9
REVIEW
Alessandro Carretta, Giacomo Sollini, Federica Guaraldi, Arianna Rustici, Marcello Magnani, Sofia Asioli, Marco Faustini-Fustini, Ernesto Pasquini, Matteo Zoli, Diego Mazzatenta
Background/Objectives : Clivus metastases from distant neoplasms are uncommon occurrences both in clinical practice and the neurosurgical literature. Surgical management is debated, particularly about the role of surgery and the preferable approach. The aim of this study was to report our surgical experience and review the concerning literature. Methods : Our institutional registry was retrospectively reviewed, and patients who underwent surgical treatment for clival metastasis from 1998 to 2023 were included...
April 27, 2024: Journal of Clinical Medicine
#10
REVIEW
Filippo Marino, Stefano Moretto, Francesco Rossi, Carlo Gandi, Filippo Gavi, Riccardo Bientinesi, Marco Campetella, Pierluigi Russo, Francesco Pio Bizzarri, Eros Scarciglia, Mauro Ragonese, Nazario Foschi, Angelo Totaro, Nicolò Lentini, Roberta Pastorino, Emilio Sacco
Background/Objectives : to assess surgical, oncological, and functional outcomes of robot-assisted radical prostatectomy (RARP) performed using the novel Hugo™ RAS system. Methods : A systematic review was conducted following the PRISMA guidelines, using PubMed, Web of Science, Scopus, and Embase databases. Eligible papers included studies involving adult males undergoing RARP with the Hugo™ RAS platform, with at least ten patients analyzed. The pooled analysis was performed using a random-effect model...
April 26, 2024: Journal of Clinical Medicine
#11
REVIEW
Themistoklis Bellos, Ioannis Manolitsis, Stamatios Katsimperis, Patrick Juliebø-Jones, Georgios Feretzakis, Iraklis Mitsogiannis, Ioannis Varkarakis, Bhaskar K Somani, Lazaros Tzelves
With the rapid increase in computer processing capacity over the past two decades, machine learning techniques have been applied in many sectors of daily life. Machine learning in therapeutic settings is also gaining popularity. We analysed current studies on machine learning in robotic urologic surgery. We searched PubMed/Medline and Google Scholar up to December 2023. Search terms included "urologic surgery", "artificial intelligence", "machine learning", "neural network", "automation", and "robotic surgery"...
May 4, 2024: Cancers
#12
JOURNAL ARTICLE
Sarah R Rivas, Mynor J Mendez Valdez, Jay S Chandar, Jelisah F Desgraves, Victor M Lu, Leo Ampie, Eric B Singh, Deepa Seetharam, Christian K Ramsoomair, Anna Hudson, Shreya M Ingle, Vaidya Govindarajan, Tara T Doucet-O'Hare, Catherine DeMarino, John D Heiss, Avindra Nath, Ashish H Shah
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear. To better understand the pleiotropic anticancer effects of ART on GBM, we conducted a comprehensive drug repurposing analysis of ART in GBM to highlight its utility in translational neuro-oncology...
April 30, 2024: Cancers
#13
REVIEW
Andrianos Tsekrekos, Yasuhiro Okumura, Ioannis Rouvelas, Magnus Nilsson
Significant progress has been made in the surgical management of gastric cancer over the years, and previous discrepancies in surgical practice between different parts of the world have gradually lessened. A transition from the earlier period of progressively more extensive surgery to the current trend of a more tailored and evidence-based approach is clear. Prophylactic resection of adjacent anatomical structures or neighboring organs and extensive lymph node dissections that were once assumed to increase the chances of long-term survival are now performed selectively...
April 29, 2024: Cancers
#14
JOURNAL ARTICLE
Roos M G van Vuren, Yester F Janssen, Rianne N M Hogenbirk, Michelle R de Graaff, Rinske van den Hoek, Schelto Kruijff, David J Heineman, Willemijn Y van der Plas, Michel W J M Wouters
UNLABELLED: To avoid delay in oncological treatment, a 6-weeks norm for time to treatment has been agreed on in The Netherlands. However, the impact of the COVID-19 pandemic on health systems resulted in reduced capacity for regular surgical care. In this study, we investigated the impact of the COVID-19 pandemic on time to treatment in surgical oncology in The Netherlands. METHODS: A population-based analysis of data derived from five surgical audits, including patients who underwent surgery for lung cancer, colorectal cancer, upper gastro-intestinal, and hepato-pancreato-biliary (HPB) malignancies, was performed...
April 29, 2024: Cancers
#15
REVIEW
Martin Heidinger, Walter P Weber
Axillary surgery for patients with breast cancer (BC) in 2024 is becoming increasingly specific, moving away from the previous 'one size fits all' radical approach. The goal is to spare morbidity whilst maintaining oncologic safety. In the upfront surgery setting, a first landmark randomized controlled trial (RCT) on the omission of any surgical axillary staging in patients with unremarkable clinical examination and axillary ultrasound showed non-inferiority to sentinel lymph node (SLN) biopsy (SLNB). The study population consisted of 87...
April 23, 2024: Cancers
#16
JOURNAL ARTICLE
Keyi Zhang, Yue Zhang, Huiyun Wu, Shan Wu, Wenjun Cheng, Chengyan Luo
BACKGROUND: Due to previous surgical history and subsequent adhesions between pelvic organs, surgery for cervical stump cancer (CSC) is technically more challenging than surgery for cervical cancer with an intact uterus.1 We aimed to illustrate the related anatomy, surgical steps and techniques of complete laparoscopic type C2 radical surgery (CLRS) for early-stage CSC. METHODS: CLRS for six patients with CSC was performed from January 2021 to January 2022. We demonstrated the detailed skills of parametrial management during CLRS for CSC in case 5 by means of a video...
May 10, 2024: Annals of Surgical Oncology
#17
JOURNAL ARTICLE
Akira Kazama, Carlos Munoz-Lopez, Worapat Attawettayanon, Melissa Boumitri, Eran Maina, Zaeem Lone, Nityam Rathi, Kieran Lewis, Rebecca A Campbell, Diego Aguilar Palacios, Jihad Kaouk, Georges-Pascal Haber, Samuel Haywood, Nima Almassi, Christopher J Weight, Erick M Remer, Ryan Ward, Amy S Nowacki, Steven C Campbell
OBJECTIVES: Most renal tumors merely displace nephrons while others can obliterate parenchyma in an invasive manner. Substantial parenchymal volume replacement (PVR) by renal cell carcinoma (RCC) may have oncologic implications; however, studies regarding PVR remain limited. Our objective was to evaluate the oncologic implications associated with PVR using improved methodology including more accurate and objective tools. PATIENTS/METHODS: A total of 1,222 patients with non-metastatic renal tumors managed with partial nephrectomy (PN) or radical nephrectomy (RN) at Cleveland Clinic (2011-2014) with necessary studies were retrospectively evaluated...
May 9, 2024: Urologic Oncology
#18
JOURNAL ARTICLE
Juhi M Purswani, Eliana Goldberg, Oren Cahlon, Freya Schnabel, Deborah Axelrod, Amber Guth, Carmen A Perez, Fauzia Shaikh, Moses Tam, Silvia Formenti, Bea Reig, Naamit K Gerber
PURPOSE: With transition from supine to prone, tenting of the pectoralis major occurs displacing the muscle from the chest wall and shifting the level I-II axillary spaces. For patients whom we aim to treat the level I-II axilla using the prone technique, accurate delineation of these nodal regions is necessary. While different consensus guidelines exist for delineation of nodal anatomy supine, to our knowledge there are no contouring guidelines in the prone position that account for this change in nodal anatomy...
May 8, 2024: Practical Radiation Oncology
#19
JOURNAL ARTICLE
Maria Pia Federica Dorma, Giuseppe Giuliani, Francesco Guerra, Francesco Santelli, Alessandro Esposito, Matteo De Pastena, Giulia Turri, Corrado Pedrazzani, Emanuele Federico Kauffmann, Ugo Boggi, Leonardo Solaini, Giorgio Ercolani, Laura Mastrangelo, Elio Jovine, Gregorio Di Franco, Luca Morelli, Michele Mazzola, Giovanni Ferrari, Serena Langella, Alessandro Ferrero, Roberta La Mendola, Mohamnad Abu Hilal, Norma Depalma, Stefano D'Ugo, Marcello Giuseppe Spampinato, Marco Frisini, Alberto Brolese, Raffaele Palaia, Andrea Belli, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Andrea Sagnotta, Stefano Mancini, Enrico Pinotti, Mauro Montuori, Alessandro Coppola, Fabrizio Di Benedetto, Andrea Coratti
BACKGROUND: In this article we aimed to perform a subgroup analysis using data from the COVID-AGICT study, to investigate the perioperative outcomes of patients undergoing surgery for pancreatic cancers (PC) during the COVID-19 pandemic. METHODS: The primary endpoint of the study was to find out any difference in the tumoral stage of surgically treated PC patients between 2019 and 2020. Surgical and oncological outcomes of the entire cohort of patients were also appraised dividing the entire peri-pandemic period into six three-month timeframes to balance out the comparison between 2019 and 2020...
April 26, 2024: Surgical Oncology
#20
Primary extradural meningioma with a history of traumatic head injury during infancy: A case report.
Elliot J D Crene, Claudia J K Cockburn, William J Cockburn
INTRODUCTION AND IMPORTANCE: Meningiomas are an extra-axial tumour arising from arachnoid cells and are typically benign and slow growing. Primary extradural meningiomas refer to meningiomas that arise outside the subdural compartment and are extremely rare (0.3 % of meningiomas). CASE PRESENTATION: A 42-year-old female presented to her primary health care provider with a 2-year history of a painful mass on her left forehead with a past medical history of a traumatic brain injury and intracranial hematoma from a motor vehicle accident when she was 11 months old...
May 8, 2024: International Journal of Surgery Case Reports
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